In the Big Data area, analysing data-intensive genomes is a complex task and needs combined knowledge and tools of specialists in the domains of genomics, data analysis and high performance computing (HPC). In particular, genome analysis pipelines usually require high performance compute clusters and large-scale, fast storage systems. In the following workshop we will provide both theoretical as well as hands-on experience on how to efficiently use computational tools on KAIMRC’s modern HPC infrastructure to analyse biological data.