Ratio H/L exp14 rep1 20h Ratio H/L exp14 rep2 20h Ratio H/L exp14 rep3 20h Ratio H/L Normalized exp14 rep1 20h Ratio H/L Normalized exp14 rep2 20h Ratio H/L Normalized exp14 rep3 20h Pfam Names GOCC Names GOMF Names GOBP Names KEGG Pathway Names Reverse Contaminant Contaminant_2 Peptides (seq) Razor Peptides (seq) Unique Peptides (seq) Sequence Coverage [%] Unique + Razor Sequence Coverage [%] Unique Sequence Coverage [%] Mol. Weight [kDa] PEP Intensity Intensity L Intensity H id Protein IDs Protein Names Gene Names Uniprot ENSEMBL KEGG Ortholog Proteins #!{Description} This column indicates which data points were selcted in the scatter plot. #!{Type}E E E E E E C C C C C C C C N N N N N N N N N N N N T T T T T T T 0.040798 37.592 0.032945 0.054902 25.232 0.043363 Filament cell part;cytoskeletal part;intermediate filament;intracellular organelle part;intracellular part;organelle part binding;protein binding;structural constituent of epidermis;structural molecule activity anatomical structure development;developmental process;epidermis development;tissue development + 46 46 32 63.1 63.1 51.6 59.51 0 20320000000 19652000000 667290000 0 IPI:CON_00009865.2;IPI:IPI00009865.4;IPI:CON_IPI00418663.3;IPI:IPI00418663.3;IPI:CON_IPI00328103.3;IPI:IPI00328103.3;IPI:CON_00703407.2;IPI:CON_IPI00004550.5;IPI:IPI00004550.5;IPI:CON_IPI00375911.2;IPI:IPI00375911.2 Keratin, type I cytoskeletal 10;Cytokeratin-10;Keratin-10 KRT10;KPP P13645 ENST00000269576 K07604 11 0.079181 14.252 NaN 0.11274 9.3324 NaN Filament cell part;cytoskeletal part;intermediate filament;intracellular organelle part;intracellular part;organelle part structural molecule activity anatomical structure development;developmental process;epidermis development;tissue development + 19 14 2 40 32.3 3.5 49.586 1.6437E-160 95002000 84699000 10303000 1 IPI:CON_00009866.6;IPI:CON_IPI00009866.6 Keratin, type I cytoskeletal 13;Cytokeratin-13;Keratin-13 KRT13 P13646-1;P13646 ENST00000157775;ENST00000246635 K07604 2 0.038591 7.0086 0.082213 0.056512 4.2573 0.10929 Filament cell part;cytoskeletal part;intermediate filament;intracellular organelle part;intracellular part;keratin filament;organelle part binding;protein binding;structural constituent of cytoskeleton;structural molecule activity anatomical structure development;developmental process;epidermis development;tissue development + 39 30 9 53.2 43.9 15.9 62.378 0 1669600000 1531600000 138050000 2 IPI:CON_00009867.3;IPI:IPI00009867.3 Keratin, type II cytoskeletal 5;Cytokeratin-5;Keratin-5;58 kDa cytokeratin KRT5 P13647 ENST00000252242 K07605 2 0.053153 7.91 0.045563 0.078731 4.9924 0.063038 Filament centrosome;cytoplasmic part;cytoskeletal part;intermediate filament;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;microtubule organizing center;non-membrane-bounded organelle;organelle;organelle part binding;protein binding;structural constituent of cytoskeleton;structural molecule activity cell activation;cell migration;cell motility;cell motion;cell proliferation;cellular process;developmental process;keratinization;keratinocyte activation;keratinocyte migration;keratinocyte proliferation + 47 43 30 60.3 57.8 42.6 65.865 0 8590300000 6511500000 2078800000 3 IPI:CON_00021304.1;IPI:IPI00021304.1;IPI:CON_00420312.4;IPI:CON_IPI00306959.10;IPI:IPI00306959.11;IPI:CON_IPI00847342.1;IPI:CON_IPI00736200.1 Keratin, type II cytoskeletal 2 epidermal;Cytokeratin-2e KRT2;KRT2A;KRT2E P35908 ENST00000309680 K07605 7 NaN 4.9606 NaN NaN 3.4548 NaN Filament cell part;cytoskeletal part;intermediate filament;intracellular organelle part;intracellular part;keratin filament;organelle part structural molecule activity anatomical structure morphogenesis;cellular component organization;cellular process;cytoskeleton organization;developmental process;intermediate filament-based process;keratinization;morphogenesis of an epithelium;organelle organization + 21 2 1 26.2 3.4 1.6 59.334 6.363E-236 2133100 2133100 0 6 IPI:CON_00131368.3;IPI:CON_00221797.1 Keratin, type II cytoskeletal 6A;Cytokeratin-6A;K6a keratin;Keratin-6 alpha;Keratin, type II cytoskeletal 75;Cytokeratin-75;Keratin-75;Type II keratin-18;Type II keratin-K6hf;Keratin-6 hair follicle Krt6a;Ker2;Krt2-6;Krt2-6a;Krt6;Krt75;Kb18 P50446;Q8BGZ7;Q99MH7 ENSMUST00000023788;ENSMUST00000042957 K07605 2 0.083101 9.3381 0.22665 0.11509 5.9547 0.29774 Filament cell part;cytoskeletal part;intermediate filament;intracellular organelle part;intracellular part;keratin filament;organelle part binding;protein binding;structural molecule activity + 6 4 4 12.5 9 9 56.964 7.057E-61 9448000 9380600 67419 9 IPI:CON_IPI00166205.2;IPI:CON_00166205.2;IPI:IPI00477227.3;IPI:IPI00166205.3 Keratin, type II cytoskeletal 78;Cytokeratin-78;Keratin-78;Type II keratin-40;Keratin-5b KRT78;K5B;KB40 Q8N1N4-2;Q8N1N4;Q7RTT2;Q8N1N4-1 ENST00000304620;ENST00000359499 K07605 4 0.021008 59.63 0.036872 0.025614 34.003 0.047431 Filament cell part;cytoskeletal part;intermediate filament;intracellular organelle part;intracellular part;organelle part binding;protein binding;structural constituent of cytoskeleton;structural molecule activity anatomical structure development;cell proliferation;cellular process;developmental process;epidermis development;tissue development + 32 18 15 64.1 43.8 34 51.267 0 1265200000 1225300000 39938000 10 IPI:CON_00217963.3;IPI:CON_IPI00217963.3;IPI:IPI00217963.3;IPI:CON_00135197.5;IPI:CON_IPI00021298.1;IPI:IPI00021298.1;IPI:CON_18266793;IPI:CON_IPI00375910.2;IPI:IPI00375910.2;IPI:CON_00122281.2;IPI:IPI00329240.3;IPI:IPI00554788.5;IPI:CON_IPI00166126.2;IPI:IPI00166126.2;IPI:IPI00790226.1 Keratin, type I cytoskeletal 16;Cytokeratin-16;Keratin-16 KRT16;KRT16A P08779 ENST00000301653 K07604 15 0.062218 15.789 NaN 0.079827 11.204 NaN Filament cell part;cytoskeletal part;intermediate filament;intracellular organelle part;intracellular part;keratin filament;organelle part binding;protein binding;structural constituent of cytoskeleton;structural molecule activity cell differentiation;cellular process;developmental process;ectoderm development;positive regulation of biological process;positive regulation of cell proliferation;regulation of cell proliferation;tissue development + 36 5 2 56.9 9.9 3.5 60.044 0 290020000 286690000 3322400 12 IPI:CON_00300725.7;IPI:IPI00300725.7;IPI:CON_00124499.2 Keratin, type II cytoskeletal 6A;Cytokeratin-6A;K6a keratin;Cytokeratin-6D KRT6A;K6A;KRT6D P02538 ENST00000330722 K07605 3 0.11347 23.629 0.096909 0.15602 14.911 0.13292 Filament cell part;cytoplasm;cytoskeletal part;intermediate filament;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;keratin filament;membrane-bounded organelle;nucleus;organelle;organelle part binding;protein binding;structural constituent of cytoskeleton;structural molecule activity anatomical structure formation;cellular component assembly;cellular component organization;cellular process;cytoskeleton organization;developmental process;epidermis development;intermediate filament-based process;organelle organization;tissue development + 40 36 17 71.6 66.3 36.9 51.621 0 2804000000 2616400000 187660000 14 IPI:CON_00384444.5;IPI:IPI00384444.6;IPI:CON_00468696.3;IPI:CON_IPI00468696.3;IPI:CON_00828528.1 Keratin, type I cytoskeletal 14;Cytokeratin-14;Keratin-14 KRT14 P02533 ENST00000167586 K07604 5 0.67086 11.429 NaN 0.99436 7.622 NaN Filament cell part;cytoplasm;cytoskeletal part;intermediate filament;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;nucleus;organelle;organelle part binding;protein binding;structural constituent of cytoskeleton;structural molecule activity anatomical structure development;developmental process;epidermis development;tissue development + 26 12 4 54.4 31.7 12 48.105 9.3406E-234 91075000 89750000 1325100 15 IPI:CON_00450768.7;IPI:CON_IPI00450768.7;IPI:IPI00450768.7 Keratin, type I cytoskeletal 17;Cytokeratin-17;Keratin-17;39.1 KRT17 Q04695 ENST00000326333 K07604 3 NaN 0.33832 NaN NaN 0.2304 NaN + 2 2 2 6.9 6.9 6.9 45.296 9.9162E-06 2214700 1325000 889740 19 IPI:CON_00686702.1 Q9N2I2 1 0.052577 19.796 0.057038 0.066652 12.499 0.071165 + 9 9 9 23 23 23 52.347 1.1855E-69 301590000 271620000 29964000 20 IPI:CON_00688316.2;IPI:IPI00032179.3 P41361 2 0.038637 18.021 0.18742 0.051881 11.412 0.24999 + 4 4 4 28 28 28 11.202 3.4708E-55 109890000 88169000 21717000 22 IPI:CON_00688815.2 P81644 1 0.30226 1.507 NaN 0.41027 0.95966 NaN + 4 4 4 26.6 26.6 26.6 22.336 4.4908E-68 73743000 66903000 6840200 23 IPI:CON_00690298.1 1 NaN NaN 0.15241 NaN NaN 0.19473 + 3 3 3 17.8 17.8 17.8 23.182 1.9277E-51 16961000 15725000 1235600 24 IPI:CON_00691212.1 Q3SZR3 1 0.062838 20.924 0.071389 0.07842 14.232 0.088722 + 28 28 28 17.4 17.4 17.4 248.98 0 1335800000 1252900000 82917000 25 IPI:CON_00691533.1;IPI:IPI00478809.3 Q28107 2 0.12521 20.483 1.2019 0.17217 12.898 1.6307 + 4 4 4 10.9 10.9 10.9 42.663 1.4923E-27 53595000 49247000 4348200 27 IPI:CON_00691998.1 Q58D62 1 0.14675 19.99 NaN 0.18958 13.609 NaN + 8 8 8 11.3 11.3 11.3 91.215 1.2864E-20 17655000 16923000 731530 28 IPI:CON_00692205.1 P06868 1 0.098102 10.665 0.31111 0.13842 6.8714 0.41737 + 6 6 6 14.4 14.4 14.4 51.113 1.0461E-60 54317000 53869000 447910 31 IPI:CON_00694304.1 P17697 1 0.1307 12.557 0.16654 0.18386 7.861 0.22254 + 14 14 14 32 32 32 65.19 2.7947E-239 273870000 267420000 6448100 32 IPI:CON_00694721.3 1 0.025425 29.132 0.054388 0.034146 18.955 0.069571 + 10 10 10 28.4 28.4 28.4 46.103 4.0935E-159 652610000 636200000 16409000 33 IPI:CON_00695489.1 P34955 1 NaN 2.8752 0.22299 NaN 1.9604 0.3544 EGF;TSP_1;TSP_3;TSP_C;VWC external side of plasma membrane;extracellular matrix;extracellular region part;fibrinogen complex;intracellular part;macromolecular complex;membrane-enclosed lumen;organelle lumen;organelle part;platelet alpha granule lumen;protein complex;vesicle lumen binding;calcium ion binding;collagen binding;fibronectin binding;glycoprotein binding;glycosaminoglycan binding;heparin binding;integrin binding;lipoprotein binding;pattern binding;protein binding;receptor binding;structural molecule activity activation of MAPK activity;angiogenesis;negative regulation of cytokine production;positive regulation of cytokine production;regulation of cytokine production;regulation of endothelial cell proliferation;response to hypoxia ECM-receptor interaction;Focal adhesion;TGF-beta signaling pathway + 5 5 5 4.6 4.6 4.6 129.38 1.9193E-13 6338800 5119200 1219600 34 IPI:IPI00296099.6;IPI:CON_00696401.1;IPI:IPI00018769.4;IPI:IPI00329535.2 Thrombospondin-1 THBS1;TSP;TSP1 P07996;Q28194 ENST00000260356 K04659 4 NaN NaN 0.1789 NaN NaN 0.23452 + 2 2 2 5.8 5.8 5.8 46.203 3.4703E-32 24538000 24538000 0 36 IPI:CON_00700622.3;IPI:CON_00707034.3;IPI:CON_00727712.3 Q9TTE1;A2I7N0;Q28922;Q3ZEJ6;A2I7N1 3 NaN NaN 0.043351 NaN NaN 0.05814 + 4 4 4 12.4 12.4 12.4 53.661 5.7472E-41 6332500 6328700 3816.8 38 IPI:CON_00704837.1;IPI:CON_00823795.1 Q3MHN5 2 0.065653 32.572 0.030417 0.088271 21.841 0.038649 + 9 9 9 40.1 40.1 40.1 38.418 0 3127300000 3036100000 91211000 39 IPI:CON_00707101.1 P12763 1 0.05038 19.215 0.040392 0.068554 12.355 0.050638 + 48 48 43 75.6 75.6 70.5 69.293 0 7377100000 7225000000 152160000 41 IPI:CON_00708398.1 P02769 1 NaN 1.4663 NaN NaN 0.94425 NaN + 2 2 2 4.5 4.5 4.5 51.723 5.7061E-07 3050700 2959400 91294 42 IPI:CON_00710025.1 P50448 1 0.038272 68.468 0.021882 0.05182 48.524 0.028547 + 9 9 5 66.9 66.9 44.4 15.184 1.9271E-250 5802900000 5741800000 61092000 43 IPI:CON_00710783.2;IPI:IPI00217473.5 P01966 2 0.067975 53.907 0.061609 0.094192 33.793 0.07678 Gla;Kringle;Thrombin_light;Trypsin cell fraction;cell part;extracellular region part;extracellular space;membrane;plasma membrane;soluble fraction binding;calcium ion binding;catalytic activity;endopeptidase activity;hydrolase activity;peptidase activity;protein binding;receptor activity;receptor binding;serine-type endopeptidase activity;serine-type peptidase activity;signal transducer activity acute inflammatory response;cell activation;positive regulation of protein amino acid phosphorylation;protein import into nucleus, translocation;protein modification process;regulation of protein amino acid phosphorylation Complement and coagulation cascades;Neuroactive ligand-receptor interaction;Regulation of actin cytoskeleton + 10 10 10 22.2 22.2 22.2 70.505 5.721E-155 226380000 194400000 31983000 44 IPI:CON_00710799.1;IPI:IPI00019568.1 Prothrombin;Coagulation factor II;Activation peptide fragment 1;Activation peptide fragment 2;Thrombin light chain;Thrombin heavy chain F2 P00735;P00734 ENST00000311907 K01313 2 0.63726 1.7921 0.80827 0.85742 1.1773 1.0794 + 11 10 9 3.5 3.3 3.1 409.86 1.754E-33 40744000 24083000 16661000 45 IPI:CON_00711422.1 1 0.29313 1.7224 0.21617 0.3494 1.1845 0.26823 + 5 5 5 15.5 15.5 15.5 35.979 2.7197E-37 74559000 57429000 17130000 46 IPI:CON_00712693.1;IPI:IPI00021842.1 Q03247 2 0.025757 27.68 0.035878 0.033049 19.788 0.04608 + 9 9 9 20.9 20.9 20.9 54.099 1.2973E-157 532720000 493230000 39494000 47 IPI:CON_00712934.1;IPI:IPI00298971.1 Q3ZBS7 2 NaN NaN 0.67125 NaN NaN 0.85471 + 7 2 2 7.6 3.7 3.7 59.299 1.9892E-48 63239000 32758000 30480000 48 IPI:CON_00713000.2 1 0.62927 1.7681 0.70961 0.88633 1.0653 0.9903 + 5 5 5 3.8 3.8 3.8 187.37 2.7639E-12 98832000 56071000 42760000 49 IPI:CON_00713505.1 Q2UVX4 1 NaN 4.728 NaN NaN 3.2812 NaN + 11 1 1 33 4.2 4.2 35.868 0 208840 208840 0 50 IPI:CON_00713814.2;IPI:IPI00022430.1 P10096 2 0.02105 46.604 0.13439 0.026796 30.354 0.17102 + 14 14 12 61.7 61.7 56.7 22.06 0 4459800000 4181700000 278080000 51 IPI:CON_00713928.4;IPI:CON_00716455.1;IPI:IPI00217471.3;IPI:IPI00220706.10;IPI:IPI00554676.2 Q3SX09 5 NaN NaN 0.44657 NaN NaN 0.61271 + 13 2 1 17.8 3.5 1.8 63.165 2.497E-159 4784100 2999000 1785000 52 IPI:CON_00714876.1 1 NaN 2.4321 0.79732 NaN 1.6958 0.94573 + 5 5 5 5.8 5.8 5.8 106.19 1.7272E-26 24717000 18158000 6558500 53 IPI:CON_00715287.2;IPI:IPI00305461.3 Q9TRI1 2 0.074696 5.9499 0.2174 0.10765 4.0529 0.27044 + 14 14 14 57.4 57.4 57.4 30.276 2.3947E-142 550520000 460520000 90001000 54 IPI:CON_00715548.1 P15497 1 NaN 1.5906 NaN NaN 1.1352 NaN + 7 7 7 4.9 4.9 4.9 192.99 3.4839E-84 58784000 37088000 21696000 55 IPI:CON_00727340.2;IPI:CON_00710490.3;IPI:IPI00032258.4;IPI:IPI00654875.1 P01030 4 0.098621 18.822 0.22959 0.12445 13.4 0.31217 + 20 20 20 18.8 18.8 18.8 164.34 2.6896E-167 61441000 59810000 1631700 56 IPI:CON_00729194.2;IPI:IPI00025426.3 2 NaN NaN 0.070257 NaN NaN 0.087152 Serum_albumin cytoplasmic part;cytoplasmic vesicle part;extracellular region part;extracellular space;intracellular part;macromolecular complex;membrane-enclosed lumen;organelle lumen;organelle part;platelet alpha granule lumen;protein complex;vesicle lumen antioxidant activity;binding;carboxylic acid binding;copper ion binding;DNA binding;drug binding;fatty acid binding;lipid binding;nucleic acid binding;protein binding;pyridoxal phosphate binding;steroid binding;toxin binding;vitamin binding cell communication;cell killing;cellular process;cellular response to starvation;cytolysis by symbiont of host cells;killing by symbiont of host cells;response to external stimulus;response to extracellular stimulus;response to stress;transport + 21 16 16 35.5 29.2 29.2 69.366 2.4404E-148 127440000 123290000 4145600 57 IPI:CON_00745872.2;IPI:CON_IPI00745872.2;IPI:IPI00745872.2;IPI:IPI00384697.2 Serum albumin ALB;GIG20;GIG42;PRO0903;PRO1708;PRO2044;PRO2619;PRO2675;UNQ696/PRO1341 P02768-1;P02768;P02768-2 ENST00000295897;ENST00000380904 4 0.084111 13.565 0.11129 0.11683 8.0568 0.15137 + 31 31 29 53.7 53.7 50.7 77.738 0 832560000 802250000 30315000 58 IPI:CON_00788576.1;IPI:CON_SEROTRANS;IPI:IPI00022463.1;IPI:CON_00705493.3 Q0IIK2;Q29443 4 NaN NaN 0.21424 NaN NaN 0.2693 + 2 2 2 4.3 4.3 4.3 46.897 1.5197E-14 3979200 3979200 0 60 IPI:CON_00826162.1;IPI:CON_00689530.2 A2I7N3;Q27984 2 NaN 0.87415 NaN NaN 0.5783 NaN Filament cell part;cytoskeletal part;intermediate filament;intracellular organelle part;intracellular part;organelle part binding;protein binding;structural constituent of cytoskeleton;structural molecule activity anatomical structure development;developmental process;epidermis development;tissue development + 7 6 1 13.9 12.3 2.4 47.232 2.5737E-22 122210000 118540000 3672900 65 IPI:CON_6016413;IPI:IPI00032513.3;IPI:CON_109456;IPI:CON_6686299;IPI:IPI00031423.1;IPI:CON_6685563;IPI:IPI00297632.4;IPI:CON_140456;IPI:CON_00849205.1;IPI:CON_IPI00108478.1;IPI:IPI00796822.3;IPI:CON_110456;IPI:CON_6685564;IPI:CON_6016414;IPI:IPI00291540.3;IPI:CON_18266794;IPI:IPI00297641.2;IPI:IPI00552959.3;IPI:CON_108456 Keratin, type I cuticular Ha1;Hair keratin, type I Ha1;Keratin-31;Keratin, type I cuticular Ha3-II;Hair keratin, type I Ha3-II;Keratin-33B;Keratin, type I cuticular Ha3-I;Hair keratin, type I Ha3-I;Keratin-33A;Keratin, type I cuticular Ha4;Hair keratin, type I Ha4;Keratin-34 KRT31;HHA1;HKA1;KRTHA1;KRT33B;HHA3-II;HKA3B;KRTHA3B;KRT33A;HHA3-I;HKA3A;KRTHA3A;Krt34;Ha4;Krt1-4;KRT34;HHA4;HKA4;KRTHA4 Q15323;Q9UE12;Q14525;O76009;Q6NTB9;Q9D646;O76011;Q8IUT8 ENST00000251645;ENST00000393998;ENST00000251646;ENST00000394004;ENST00000007735;ENSMUST00000056362;ENST00000251648 K07604 19 0.088743 5.9194 0.092274 0.12101 4.0706 0.1125 + 9 9 9 38.2 38.2 38.2 22.975 2.331E-81 42845000 41697000 1147700 67 IPI:CON_CASA1 P02662 1 NaN NaN 0.14374 NaN NaN 0.18346 + 3 3 3 23.7 23.7 23.7 18.974 5.8296E-83 31695000 31507000 188400 70 IPI:CON_CASK P02668 1 0.65981 1.9884 0.50309 0.87143 1.2734 0.67715 Enolase_C;Enolase_N cell fraction;fungal-type vacuole;intracellular organelle;lytic vacuole;macromolecular complex;membrane-bounded organelle;mitochondrion;organelle;phosphopyruvate hydratase complex;plasma membrane enriched fraction;storage vacuole;vacuole binding;carbon-oxygen lyase activity;catalytic activity;cation binding;hydro-lyase activity;ion binding;lyase activity;magnesium ion binding;metal ion binding;phosphopyruvate hydratase activity;protein binding alcohol metabolic process;carbohydrate metabolic process;generation of precursor metabolites and energy;glucose catabolic process;glucose metabolic process;monosaccharide metabolic process;organic acid metabolic process;pyruvate metabolic process Glycolysis / Gluconeogenesis + 3 1 1 4.3 2.3 2.3 46.802 1.7053E-06 137890000 81101000 56789000 71 IPI:CON_ENO1;IPI:CON_ENO2 Enolase 1;2-phosphoglycerate dehydratase 1;2-phospho-D-glycerate hydro-lyase 1;Enolase 2;2-phosphoglycerate dehydratase 2;2-phospho-D-glycerate hydro-lyase 2 ENO1;ENOA;HSP48;YGR254W;G9160;ENO2;ENOB;YHR174W P00924;P00925 YGR254W;YHR174W K01689 2 0.086373 8.3169 NaN 0.12735 5.5136 NaN Filament cell part;cytoskeletal part;intermediate filament;intracellular organelle part;intracellular part;keratin filament;organelle part structural molecule activity cellular component organization;cellular process;cytoskeleton organization;organelle organization + 12 3 3 14.7 6.1 6.1 65.87 5.9774E-78 6808700 6630000 178640 73 IPI:CON_IPI00008359.1;IPI:IPI00008359.1 Keratin, type II cytoskeletal 2 oral;Cytokeratin-2P;Keratin-76 KRT76;KRT2B;KRT2P Q01546 ENST00000332411 K07605 2 0.074233 2.5824 0.27236 0.093379 1.7457 0.34223 Filament cell part;cytoskeletal part;intermediate filament;intracellular organelle part;intracellular part;keratin filament;organelle part structural molecule activity + 14 9 7 21.8 16.4 12.3 61.802 2.6095E-166 36805000 34862000 1942800 75 IPI:CON_IPI00376379.3;IPI:IPI00376379.4 Keratin, type II cytoskeletal 1b;Cytokeratin-1B;Keratin-77 KRT77;KRT1B Q7Z794 ENST00000341809 2 NaN 4.6369 NaN NaN 2.5911 NaN Filament cell part;cytoskeletal part;intermediate filament;intracellular organelle part;intracellular part;keratin filament;organelle part binding;protein binding;structural molecule activity cellular component organization;cellular process;cytoskeleton organization;interspecies interaction between organisms;multi-organism process;organelle organization + 7 1 1 9.1 2.3 2.3 53.704 7.1636E-22 1216000 919310 296700 76 IPI:CON_IPI00554648.3;IPI:IPI00554648.3;IPI:CON_IPI00017870.1;IPI:CON_IPI00787323.2 Keratin, type II cytoskeletal 8;Cytokeratin-8;Keratin-8;Keratin-8-like protein 1. KRT8;CYK8;KRT8P11;RP11-13B9.3-001 P05787;Q9H552 ENST00000293308 K07605 4 0.35699 2.0326 NaN 0.475 1.3407 NaN Filament cell part;cytoskeletal part;intermediate filament;intracellular organelle part;intracellular part;keratin filament;organelle part structural molecule activity + 5 5 5 13.1 13.1 13.1 50.525 2.9719E-23 7899200 5043800 2855300 77 IPI:CON_IPI00853265.1;IPI:IPI00853265.1;IPI:IPI00431749.2;IPI:IPI00375843.3;IPI:CON_00660358.2 Keratin, type II cytoskeletal 80;Cytokeratin-80;Keratin-80;Type II keratin-20 KRT80;KB20 Q6KB66-1;Q6KB66;Q6KB66-2;Q6KB66-3 ENST00000301446;ENST00000394815 5 0.052885 13.621 0.11913 0.07026 8.7533 0.16227 + 5 5 5 32.9 32.9 32.9 24.409 5.1902E-200 15136000000 14992000000 143940000 81 IPI:CON_Trypsin P00761 1 0.7718 1.5725 0.73261 1.0771 1.0053 1.0383 dsrm endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;microtubule associated complex;organelle;organelle part;protein complex;rough endoplasmic reticulum binding;double-stranded RNA binding;nucleic acid binding;protein binding;RNA binding 14 14 14 20.1 20.1 20.1 63.182 2.8215E-109 227120000 120800000 106320000 82 IPI:IPI00000001.2;IPI:IPI00218609.2 Double-stranded RNA-binding protein Staufen homolog 1 STAU1;STAU O95793-1;O95793;O95793-2 ENST00000347458;ENST00000360426;ENST00000371856;ENST00000396163 2 1.1758 1.9207 1.1994 1.5389 1.3464 1.573 Ras cell part;cytoplasmic part;Golgi apparatus part;Golgi membrane;intracellular organelle part;intracellular part;membrane;organelle membrane;organelle part;plasma membrane binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding biological regulation;cell communication;cellular process;intracellular signaling cascade;Ras protein signal transduction;regulation of biological process;regulation of cellular process;signal transduction;small GTPase mediated signal transduction Acute myeloid leukemia;Axon guidance;B cell receptor signaling pathway;Bladder cancer;Chemokine signaling pathway;Chronic myeloid leukemia;Endometrial cancer;ErbB signaling pathway;Fc epsilon RI signaling pathway;Gap junction;Glioma;GnRH signaling pathway;Insulin signaling pathway;Long-term depression;Long-term potentiation;MAPK signaling pathway;Melanogenesis;Melanoma;Natural killer cell mediated cytotoxicity;Non-small cell lung cancer;Pathways in cancer;Prostate cancer;Regulation of actin cytoskeleton;Renal cell carcinoma;T cell receptor signaling pathway;Thyroid cancer;Tight junction;VEGF signaling pathway 6 6 2 32.3 32.3 12.7 21.229 3.5903E-86 214200000 109740000 104470000 83 IPI:IPI00000005.1 GTPase NRas;Transforming protein N-Ras NRAS;HRAS1 P01111 ENST00000369535;ENST00000406761 K07828 1 NaN 1.3605 0.92879 NaN 0.84579 1.2295 Ras cell part;cytoplasmic part;Golgi apparatus part;Golgi membrane;intracellular organelle part;intracellular part;membrane;organelle membrane;organelle part;plasma membrane binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;protein binding;protein C-terminus binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding behavior;cell communication;cell surface receptor linked signal transduction;chemotaxis;intracellular signaling cascade;locomotory behavior;Ras protein signal transduction;signal transduction;small GTPase mediated signal transduction Acute myeloid leukemia;Axon guidance;B cell receptor signaling pathway;Bladder cancer;Chemokine signaling pathway;Chronic myeloid leukemia;Endometrial cancer;ErbB signaling pathway;Fc epsilon RI signaling pathway;Focal adhesion;Gap junction;Glioma;GnRH signaling pathway;Insulin signaling pathway;Long-term depression;Long-term potentiation;MAPK signaling pathway;Melanogenesis;Melanoma;Natural killer cell mediated cytotoxicity;Non-small cell lung cancer;Pathways in cancer;Prostate cancer;Regulation of actin cytoskeleton;Renal cell carcinoma;T cell receptor signaling pathway;Thyroid cancer;Tight junction;VEGF signaling pathway 5 2 1 29.6 16.4 8.5 21.298 6.5018E-79 8043600 4238300 3805300 84 IPI:IPI00000006.1 GTPase HRas;Transforming protein p21;p21ras;H-Ras-1;c-H-ras;Ha-Ras;GTPase HRas, N-terminally processed HRAS;HRAS1 P01112 ENST00000311189;ENST00000388730;ENST00000397596 K02833 1 0.84672 2.1801 0.68652 1.1796 1.3029 1.103 RRM_1 cell part;intracellular organelle part;intracellular part;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part binding;catalytic activity;nucleic acid binding;nucleotide binding;RNA binding;RNA splicing factor activity, transesterification mechanism nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 6 4 4 9.1 5.9 5.9 56.678 2.1229E-20 42369000 22586000 19783000 85 IPI:IPI00000015.2 Splicing factor, arginine/serine-rich 4;Pre-mRNA-splicing factor SRP75;SRP001LB SFRS4;SRP75 Q08170 ENST00000373795 1 0.68993 1.3548 0.73114 0.94291 0.93191 0.95241 B56 cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;nucleus;organelle;protein complex;protein phosphatase type 2A complex;protein serine/threonine phosphatase complex binding;enzyme regulator activity;phosphatase regulator activity;protein binding;protein phosphatase regulator activity;protein phosphatase type 2A regulator activity anatomical structure development;biological regulation;cell communication;cellular process;developmental process;nervous system development;regulation of biological process;regulation of cellular process;signal transduction;system development Wnt signaling pathway 20 20 13 32.4 32.4 22.1 69.991 3.4362E-201 642620000 375680000 266940000 86 IPI:IPI00000030.1;IPI:IPI00219543.1;IPI:IPI00219544.1 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform;PP2A, B subunit, B' delta isoform;PP2A, B subunit, B56 delta isoform;PP2A, B subunit, PR61 delta isoform;PP2A, B subunit, R5 delta isoform PPP2R5D Q14738-1;Q14738;Q14738-2;Q14738-3 ENST00000230402;ENST00000394110 K11584 3 0.77169 1.726 0.85954 1.0799 1.092 1.1097 Prefoldin_2 cell part;cytoplasmic part;cytosolic part;intracellular part;macromolecular complex;membrane;plasma membrane;prefoldin complex;protein complex binding;DNA binding;nucleic acid binding;protein binding;transcription factor activity;transcription regulator activity;unfolded protein binding biopolymer metabolic process;cell cycle;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 5 5 5 37.7 37.7 37.7 14.21 3.0328E-17 861080000 458350000 402740000 87 IPI:IPI00000051.4 Prefoldin subunit 1 PFDN1;PFD1 O60925 ENST00000261813 K09548 1 0.83864 1.5889 0.79969 1.2635 1.0211 1.0862 COG2 cell part;cytoplasmic part;Golgi apparatus part;Golgi membrane;Golgi transport complex;intracellular organelle part;intracellular part;macromolecular complex;membrane;organelle membrane;organelle part;protein complex binding;protein binding;protein transporter activity;substrate-specific transporter activity;transporter activity biosynthetic process;carbohydrate metabolic process;Golgi organization;intracellular protein transport;intra-Golgi vesicle-mediated transport;metabolic process;organelle organization;protein amino acid glycosylation;protein modification process;transport 3 3 3 6 6 6 83.207 2.5178E-07 15021000 7678000 7343100 88 IPI:IPI00000057.1 Conserved oligomeric Golgi complex subunit 2;Component of oligomeric Golgi complex 2;Low density lipoprotein receptor defect C-complementing protein COG2;LDLC Q14746 ENST00000366669 1 0.47412 1.2314 NaN 0.60669 0.86768 NaN EGF;EGF_CA;Ldl_recept_a;Ldl_recept_b clathrin coated vesicle membrane;coated pit;coated vesicle membrane;cytoplasmic vesicle membrane;endocytic vesicle membrane;endosome membrane;integral to membrane;integral to plasma membrane;membrane;vesicle membrane binding;calcium ion binding;lipoprotein binding;lipoprotein receptor activity;low-density lipoprotein binding;low-density lipoprotein receptor activity;protein binding;receptor activity;signal transducer activity;transmembrane receptor activity alcohol metabolic process;carbohydrate metabolic process;endocytosis;lipid metabolic process;lipid transport;metabolic process;protein amino acid glycosylation;protein amino acid O-linked glycosylation;protein modification process;system process;transport 4 4 4 5.9 5.9 5.9 95.375 2.7586E-14 3775500 2156400 1619200 89 IPI:IPI00000070.1 Low-density lipoprotein receptor LDLR P01130 ENST00000252444 1 NaN 2.0095 NaN NaN 1.2311 NaN TGF_beta;TGFb_propeptide extracellular matrix;extracellular space;Golgi lumen;intracellular organelle;membrane-bounded organelle;membrane-enclosed lumen;nucleus;organelle;platelet alpha granule lumen;proteinaceous extracellular matrix;vesicle lumen binding;cytokine receptor binding;growth factor activity;protein binding;receptor binding;transcription activator activity;transforming growth factor beta receptor binding;type II transforming growth factor beta receptor binding cell cycle checkpoint;cell morphogenesis;cell morphogenesis involved in differentiation;ossification;protein import into nucleus, translocation;regulation of cell growth;regulation of cytokine production;regulation of DNA recombination Cell cycle;Chronic myeloid leukemia;Colorectal cancer;Cytokine-cytokine receptor interaction;MAPK signaling pathway;Pancreatic cancer;Pathways in cancer;Renal cell carcinoma;TGF-beta signaling pathway 2 2 2 6.7 6.7 6.7 44.341 2.2127E-07 1371100 838840 532240 90 IPI:IPI00000075.3 Transforming growth factor beta-1;Latency-associated peptide TGFB1;TGFB P01137 ENST00000221930 K04384 1 0.63491 NaN 0.68497 0.89573 NaN 1.0002 RnaseH binding;catalytic activity;endonuclease activity;endoribonuclease activity;hydrolase activity;hydrolase activity, acting on ester bonds;magnesium ion binding;nuclease activity;nucleic acid binding;ribonuclease activity;ribonuclease H activity;RNA binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA catabolic process;RNA metabolic process DNA replication 3 3 3 11.5 11.5 11.5 32.064 1.1214E-10 9786000 5602300 4183700 91 IPI:IPI00000077.1 Ribonuclease H1;Ribonuclease H type II RNASEH1;RNH1 O60930 ENST00000315212 K03469 1 0.39518 NaN 0.39294 0.53242 NaN 0.52042 DSPc;mRNA_cap_C;mRNA_cap_enzyme cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;catalytic activity;GTP binding;mRNA guanylyltransferase activity;nucleotide binding;phosphoprotein phosphatase activity;polynucleotide 5'-phosphatase activity;protein tyrosine phosphatase activity mRNA capping;mRNA processing;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid dephosphorylation;protein modification process;RNA processing 2 2 2 3.4 3.4 3.4 68.556 3.2887E-19 6185200 3834300 2350900 92 IPI:IPI00000104.1;IPI:IPI00219610.1;IPI:IPI00219611.2;IPI:IPI00219612.1 mRNA-capping enzyme;HCE;HCAP1;Polynucleotide 5'-triphosphatase;mRNA 5'-triphosphatase;mRNA guanylyltransferase;GTP--RNA guanylyltransferase RNGTT;CAP1A O60942-1;O60942;O60942-2;O60942-3;O60942-4 ENST00000265607;ENST00000369485 K00987;K01098 4 0.84403 1.6793 0.90829 1.1339 1.1445 1.207 DED;Peptidase_C14 centrosome;cytosol;death-inducing signaling complex;intracellular organelle;macromolecular complex;membrane-bounded organelle;microtubule organizing center;mitochondrion;non-membrane-bounded organelle;nucleus;organelle binding;catalytic activity;cysteine-type endopeptidase activity;cysteine-type peptidase activity;endopeptidase activity;hydrolase activity;identical protein binding;peptidase activity;peptidase activity, acting on L-amino acid peptides;protein binding activation of pro-apoptotic gene products;catabolic process;induction of apoptosis;induction of apoptosis by extracellular signals;macromolecule catabolic process;metabolic process;proteolysis;regulation of signal transduction Alzheimer's disease;Apoptosis;Huntington's disease;p53 signaling pathway;Pathways in cancer;Toll-like receptor signaling pathway 5 5 5 11 11 11 61.863 2.3163E-141 23543000 12419000 11124000 96 IPI:IPI00220726.1;IPI:IPI00305242.3;IPI:IPI00000149.1;IPI:IPI00220721.1;IPI:IPI00220722.1;IPI:IPI00073318.1;IPI:IPI00793235.2;IPI:IPI00220723.1;IPI:IPI00220724.1 Caspase-8;ICE-like apoptotic protease 5;MORT1-associated CED-3 homolog;FADD-homologous ICE/CED-3-like protease;FADD-like ICE;Apoptotic cysteine protease;Apoptotic protease Mch-5;CAP4;Caspase-8 subunit p18;Caspase-8 subunit p10 CASP8;MCH5 Q14790-9;Q14790;Q14790-4;Q14790-1;Q14790-2;Q14790-3;Q14790-7;Q14790-8;Q14790-5;Q14790-6 ENST00000264274;ENST00000264275;ENST00000303385;ENST00000323492;ENST00000339403;ENST00000358485;ENST00000392258;ENST00000392259;ENST00000392264;ENST00000392266 K04398 9 0.90133 1.7593 1.0677 1.2058 1.0969 1.43 AT_hook;NAD_binding_2;PWWP cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;DNA binding;nucleic acid binding;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;phosphogluconate dehydrogenase (decarboxylating) activity alcohol metabolic process;carbohydrate metabolic process;glucose catabolic process;glucose metabolic process;monosaccharide metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;pentose-phosphate shunt 10 10 10 22.1 22.1 22.1 60.556 3.5813E-145 129600000 68002000 61593000 97 IPI:IPI00000155.7;IPI:IPI00647648.3;IPI:IPI00910934.2;IPI:IPI00644210.3;IPI:IPI00647134.3 Nuclear protein NP60;Nuclear protein of 60 kDa;3-hydroxyisobutyrate dehydrogenase-like protein;Cytokine-like nuclear factor N-PAC NP60;HIBDL Q49A26-1;Q49A26;Q49A26-2;Q49A26-5;Q49A26-4;Q49A26-3 ENST00000321919;ENST00000381983 5 0.59435 1.1858 0.67581 0.80391 0.81094 0.82863 Sas10_Utp3 axon;cell part;cell projection;cytoplasm;dendrite;filopodium;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;neuron projection;nucleus;organelle posttranscriptional regulation of gene expression;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of metabolic process;regulation of translation 4 4 4 16.5 16.5 16.5 35.894 3.2887E-100 42248000 22556000 19692000 98 IPI:IPI00000162.5;IPI:IPI00410360.3 Neuroguidin;EIF4E-binding protein NGDN;C14orf120 Q8NEJ9-1;Q8NEJ9;Q8NEJ9-2 ENST00000397154;ENST00000408901 2 0.8592 1.6175 NaN 1.2227 1.0965 NaN TSC22 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;protein binding;transcription factor activity;transcription regulator activity;transcription repressor activity biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 4 4 4 13.7 13.7 13.7 41.026 1.379E-11 9734700 5086700 4648000 99 IPI:IPI00000171.1 TSC22 domain family protein 4;TSC22-related-inducible leucine zipper protein 2;Tsc-22-like protein THG-1 TSC22D4;TILZ2 Q9Y3Q8 ENST00000300181 1 0.67478 1.4288 0.79409 0.89372 0.90285 1.0581 Tetraspannin cell part;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part binding;protein binding activation of MAPK activity;lipid metabolic process;phospholipid metabolic process;positive regulation of protein amino acid phosphorylation;protein amino acid phosphorylation;protein modification process;regulation of protein amino acid phosphorylation B cell receptor signaling pathway 3 3 3 19.1 19.1 19.1 25.809 8.5601E-59 88989000 47131000 41857000 101 IPI:IPI00000190.1 CD81 antigen;26 kDa cell surface protein TAPA-1;Target of the antiproliferative antibody 1;Tetraspanin-28 CD81;TAPA1;TSPAN28 P60033 ENST00000263645;ENST00000381036 K06508 1 0.65242 1.3886 0.68995 0.88678 0.80438 0.98443 zf-CCCH cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding 8 8 8 22.7 22.7 22.7 49.143 2.2247E-140 131920000 71692000 60229000 103 IPI:IPI00000279.3 Zinc finger CCCH domain-containing protein 15;DRG family-regulatory protein 1;Likely ortholog of mouse immediate early response erythropoietin 4 ZC3H15;DFRP1;LEREPO4;HSPC303;HT010;MSTP012;PP730 Q8WU90 ENST00000337859 1 0.82404 1.4719 0.78608 1.039 1.0325 0.97849 cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle Regulation of actin cytoskeleton 3 3 3 26.4 26.4 26.4 12.046 1.0022E-10 52808000 29246000 23562000 104 IPI:IPI00844425.1;IPI:IPI00000296.2 Probable protein BRICK1 C3orf10;HSPC300;MDS027 Q8WUW1-2;Q8WUW1;Q8WUW1-1 ENST00000404328 K05752 2 0.54984 1.5183 NaN 0.67608 1.0429 NaN Med11 cell part;intracellular organelle part;intracellular part;macromolecular complex;mediator complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;general RNA polymerase II transcription factor activity;protein binding;RNA polymerase II transcription factor activity;RNA polymerase II transcription mediator activity;transcription regulator activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 4 4 4 32.5 32.5 32.5 13.129 9.3095E-46 14696000 8309400 6387000 105 IPI:IPI00000305.3 Mediator of RNA polymerase II transcription subunit 11;Mediator complex subunit 11 MED11;HSPC296 Q9P086 ENST00000293777 1 0.59111 1.5773 0.79371 0.82174 0.97497 1.1326 3 3 3 26 26 26 11.425 0.00025256 14015000 7455600 6559600 106 IPI:IPI00000330.5;IPI:IPI00829819.1 Uncharacterized protein C9orf80 C9orf80;HSPC043;HSPC291 Q9NRY2-1;Q9NRY2;Q9NRY2-2 ENST00000277239;ENST00000374242 2 0.7991 1.6734 0.83455 1.0699 1.1119 1.1119 HIT cell part;cytoplasmic part;extracellular region;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle catalytic activity;hydrolase activity 3 3 3 31.3 31.3 31.3 17.162 2.3502E-129 590060000 308760000 281300000 107 IPI:IPI00000335.1 Histidine triad nucleotide-binding protein 2;HINT-3;HIT-17kDa;PKCI-1-related HIT protein HINT2 Q9BX68 ENST00000259667 1 NaN 4.6858 NaN NaN 2.797 NaN cell part;cytoplasm;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;microtubule;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;DNA binding;nucleic acid binding cytokinesis;cytokinesis after mitosis;cytoskeleton organization;DNA packaging;microtubule cytoskeleton organization;microtubule-based process;mitotic chromosome condensation;organelle organization;regulation of mitosis;regulation of mitotic cell cycle 11 1 1 33.1 4.3 4.3 49.451 1.3275E-94 642030 479780 162240 108 IPI:IPI00000398.2;IPI:IPI00020484.4;IPI:IPI00793551.1;IPI:IPI00789679.1 Nucleolar and spindle-associated protein 1 NUSAP1;ANKT;BM-037;PRO0310 Q9BXS6-1;Q9BXS6;Q9BXS6-2;Q9BXS6-5;Q9BXS6-3 ENST00000260359 4 0.66181 1.5648 0.6913 0.88323 1.0668 0.88603 V_ATPase_I endosome membrane;integral to membrane;intracellular part;intrinsic to membrane;macromolecular complex;membrane;organelle membrane;organelle part;plasma membrane;protein complex;proton-transporting two-sector ATPase complex, proton-transporting domain binding;cation transmembrane transporter activity;hydrogen ion transmembrane transporter activity;ion transmembrane transporter activity;monovalent inorganic cation transmembrane transporter activity;protein binding;transporter activity ATP biosynthetic process;immune system process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process Epithelial cell signaling in Helicobacter pylori infection;Oxidative phosphorylation;Vibrio cholerae infection 8 8 7 12.1 12.1 11.4 98.081 1.5868E-105 22783000 12956000 9826900 109 IPI:IPI00000425.2 V-type proton ATPase 116 kDa subunit a isoform 2;Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2;Lysosomal H(+)-transporting ATPase V0 subunit a2;TJ6 ATP6V0A2 Q9Y487 ENST00000330342 K02154 1 0.79851 1.6795 0.72224 1.1791 1.0019 1.0142 Kinesin cell part;cytoskeletal part;intracellular organelle part;intracellular part;microtubule;organelle part ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;microtubule motor activity;motor activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity cellular component organization;cellular process;microtubule-based movement;microtubule-based process;organelle organization 6 5 5 10.8 9.3 9.3 80.394 5.6967E-26 22998000 13035000 9963500 110 IPI:IPI00000455.7;IPI:IPI00396343.1;IPI:IPI00414252.3;IPI:IPI00607613.2;IPI:IPI00654807.2 Kinesin-like protein KIF3A;Microtubule plus end-directed kinesin motor 3A KIF3A;KIF3 Q9Y496 ENST00000378735;ENST00000395101 K10394 5 0.71476 1.3783 0.7177 0.92276 0.91851 0.91587 Ribosomal_L18p cytosolic large ribosomal subunit;intracellular non-membrane-bounded organelle;intracellular organelle;large ribosomal subunit;macromolecular complex;non-membrane-bounded organelle;nucleolus;organelle;ribonucleoprotein complex;ribosomal subunit 5S rRNA binding;binding;nucleic acid binding;protein binding;RNA binding;rRNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA processing;rRNA processing;translational elongation Ribosome 14 14 14 40.4 40.4 40.4 34.362 0 5093900000 2768800000 2325100000 111 IPI:IPI00000494.6 60S ribosomal protein L5 RPL5;MSTP030 P46777 ENST00000370321 K02932 1 0.69694 1.4989 0.69626 0.90834 0.92485 0.91776 TPR_1 binding 12 12 12 34.1 34.1 34.1 44.678 8.5354E-158 447840000 228660000 219180000 112 IPI:IPI00000606.5 Tetratricopeptide repeat protein 4 TTC4;My044 O95801 ENST00000371281;ENST00000371284 1 0.9771 1.5274 0.97029 1.2465 0.98693 1.3035 DUF2046 cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle binding;protein binding;protein domain specific binding;SH3 domain binding;structural constituent of cytoskeleton;structural molecule activity Pathways in cancer;Thyroid cancer 4 4 4 7.7 7.7 7.7 65.916 6.5654E-11 47459000 23045000 24414000 114 IPI:IPI00000634.1 Coiled-coil domain-containing protein 6;Protein H4;Papillary thyroid carcinoma-encoded protein CCDC6;D10S170;TST1 Q16204 ENST00000395341 K09288 1 0.935 1.8126 0.96901 1.259 1.1829 1.2579 BAG binding;protein binding apoptosis;biopolymer metabolic process;cell death;cellular biopolymer metabolic process;cellular metabolic process;cellular process;death;macromolecule metabolic process;metabolic process;programmed cell death;protein folding;protein metabolic process 14 14 13 61.6 61.6 58.8 23.772 0 1137100000 565540000 571560000 115 IPI:IPI00000643.1;IPI:IPI00300621.1;IPI:IPI00477078.2;IPI:IPI00515001.2 BAG family molecular chaperone regulator 2;Bcl-2-associated athanogene 2 BAG2 O95816 ENST00000370693 K09556 4 NaN 1.9092 NaN NaN 1.3459 NaN Cohesin_load extracellular region binding 2 1 1 4.2 1.8 1.8 69.081 1.6774E-13 168960 124280 44681 116 IPI:IPI00000656.2;IPI:IPI00790071.1 Uncharacterized protein KIAA0892 KIAA0892 Q9Y6X3-1;Q9Y6X3;Q9Y6X3-3 ENST00000262815;ENST00000392313 K11266 2 0.6909 1.9486 NaN 0.93889 1.3129 NaN MCD cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;microbody;mitochondrion;organelle;peroxisome carbon-carbon lyase activity;carboxy-lyase activity;catalytic activity;lyase activity;malonyl-CoA decarboxylase activity;methylmalonyl-CoA decarboxylase activity acyl-CoA metabolic process;biosynthetic process;cellular process;coenzyme metabolic process;fatty acid biosynthetic process;fatty acid metabolic process;lipid biosynthetic process;lipid metabolic process;metabolic process;organic acid metabolic process beta-Alanine metabolism;Propanoate metabolism 2 2 2 6.1 6.1 6.1 55.003 2.8076E-63 6476800 3543100 2933800 117 IPI:IPI00000663.1;IPI:IPI00759655.1 Malonyl-CoA decarboxylase, mitochondrial MLYCD O95822-1;O95822;O95822-2 ENST00000262430 K01578 2 0.67869 1.1719 0.6223 0.87002 0.81301 0.83509 UDPGP cell part;cytoplasm;intracellular part catalytic activity;nucleotidyltransferase activity;transferase activity;transferase activity, transferring phosphorus-containing groups;UDP-N-acetylglucosamine diphosphorylase activity;uridylyltransferase activity amino sugar metabolic process;carbohydrate metabolic process;glucosamine biosynthetic process;glucosamine metabolic process;monosaccharide metabolic process;N-acetylglucosamine biosynthetic process;N-acetylglucosamine metabolic process Aminosugars metabolism 14 14 13 28.7 28.7 26.2 58.768 1.7239E-135 440930000 239070000 201860000 118 IPI:IPI00000684.4;IPI:IPI00607787.1;IPI:IPI00217816.3 UDP-N-acetylhexosamine pyrophosphorylase;Antigen X;Sperm-associated antigen 2;UDP-N-acetylgalactosamine pyrophosphorylase;AGX-1;UDP-N-acetylglucosamine pyrophosphorylase;AGX-2 UAP1;SPAG2 Q16222-1;Q16222;Q16222-3;Q16222-2 ENST00000271469;ENST00000367925;ENST00000367926 K00972 3 0.37791 0.86547 0.42512 0.52895 0.55917 0.57796 Pkinase cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part catalytic activity;cyclin-dependent protein kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transcription coactivator activity;transcription cofactor activity DNA catabolic process;DNA metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleotide-excision repair, DNA damage removal;regulation of cyclin-dependent protein kinase activity;RNA elongation;transcription initiation Cell cycle;Nucleotide excision repair 7 7 7 22.5 22.5 22.5 39.038 3.5198E-87 116910000 65901000 51012000 119 IPI:IPI00000685.1 Cell division protein kinase 7;CDK-activating kinase;CAK1;TFIIH basal transcription factor complex kinase subunit;39 kDa protein kinase;P39 Mo15;STK1 CDK7;MO15 P50613 ENST00000256443 K02202 1 0.6763 1.5174 0.7676 0.94487 0.93597 1.0413 RRM_1 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;nucleic acid binding;nucleotide binding;RNA binding 9 9 9 10 10 10 107.34 1.329E-146 94628000 68109000 26519000 120 IPI:IPI00000686.2 Probable RNA-binding protein 19;RNA-binding motif protein 19 RBM19;KIAA0682 Q9Y4C8 ENST00000261741;ENST00000392561 1 0.77346 1.5488 0.7378 1.0753 0.98941 1.0147 Pyr_redox;Pyr_redox_2 intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;membrane-enclosed lumen;mitochondrial intermembrane space;mitochondrial part;nucleus;organelle;organelle envelope lumen;organelle part adenyl nucleotide binding;binding;catalytic activity;DNA binding;electron carrier activity;nucleic acid binding;nucleoside binding;nucleotide binding;oxidoreductase activity;protein binding;purine nucleoside binding;purine nucleotide binding DNA catabolic process;DNA catabolic process, endonucleolytic;DNA fragmentation involved in apoptosis;DNA metabolic process;induction of apoptosis;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 19 19 19 39.5 39.5 39.5 66.9 0 1266200000 679080000 587100000 121 IPI:IPI00000690.1;IPI:IPI00157908.4;IPI:IPI00300018.1 Apoptosis-inducing factor 1, mitochondrial;Programmed cell death protein 8 AIFM1;AIF;PDCD8 O95831-1;O95831;O95831-3;O95831-2 ENST00000287295;ENST00000319908;ENST00000346424 3 0.7557 1.651 0.83807 1.0399 1.0417 1.0999 DUF1055;UCH cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;cysteine-type endopeptidase activity;cysteine-type peptidase activity;endopeptidase activity;hydrolase activity;peptidase activity;protein binding;ubiquitin thiolesterase activity;ubiquitin-specific protease activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process 10 9 9 10.8 9.9 9.9 112.42 7.0127E-31 61965000 32601000 29364000 122 IPI:IPI00000728.3;IPI:IPI00219505.2;IPI:IPI00219504.1 Ubiquitin carboxyl-terminal hydrolase 15;Ubiquitin thioesterase 15;Ubiquitin-specific-processing protease 15;Deubiquitinating enzyme 15;Unph-2;Unph4 USP15;KIAA0529 Q9Y4E8-1;Q9Y4E8;Q9Y4E8-3;Q9Y4E8-2 ENST00000280377;ENST00000353364;ENST00000393654 K11835 3 0.66135 0.82455 0.50184 0.78895 0.58571 0.63325 intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nucleolus;organelle;organelle part;ribonucleoprotein complex;small nucleolar ribonucleoprotein complex cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 10 10 10 22.5 22.5 22.5 64.063 1.792E-141 368400000 201900000 166500000 123 IPI:IPI00000733.4 U3 small nucleolar RNA-associated protein 18 homolog;WD repeat-containing protein 50 UTP18;WDR50;CDABP0061;CGI-48 Q9Y5J1 ENST00000225298 1 0.74807 1.9175 NaN 1.0344 1.3721 NaN Amidinotransf catalytic activity;dimethylargininase activity;hydrolase activity;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines arginine catabolic process;arginine metabolic process;cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;nitric oxide biosynthetic process;nitrogen compound metabolic process;organic acid metabolic process 3 3 3 14 14 14 29.644 1.971E-40 3362400 1881800 1480600 124 IPI:IPI00000760.1 N(G),N(G)-dimethylarginine dimethylaminohydrolase 2;DDAHII;Dimethylargininase-2;S-phase protein;Protein G6a DDAH2;DDAH;G6A;NG30 O95865 ENST00000229707;ENST00000375787;ENST00000375789;ENST00000375792;ENST00000383409;ENST00000400032;ENST00000400036;ENST00000400062;ENST00000400063 K01482 1 0.60404 1.359 0.60838 0.76355 0.85908 0.76596 Kinesin intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;kinetochore;macromolecular complex;membrane-bounded organelle;microtubule;non-membrane-bounded organelle;nucleus;organelle;protein complex ATP binding;binding;catalytic activity;DNA binding;hydrolase activity;microtubule motor activity;motor activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity DNA metabolic process;DNA repair;microtubule-based process;nitrogen compound metabolic process;nuclear division;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;response to DNA damage stimulus;response to stress 5 5 5 9.2 9.2 9.2 73.261 6.0254E-26 20925000 12262000 8663600 125 IPI:IPI00000769.2 Kinesin-like protein KIF22;Kinesin-like DNA-binding protein;Kinesin-like protein 4 KIF22;KID;KNSL4 Q14807 ENST00000160827 K10403 1 0.95672 1.7491 0.94038 1.2211 1.2056 1.2145 Proteasome cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;proteasome core complex;protein complex catalytic activity;endopeptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides;threonine-type endopeptidase activity;threonine-type peptidase activity catabolic process;cellular process;immune response;immune system process;macromolecule catabolic process;metabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Proteasome 8 8 8 34.8 34.8 34.8 30.354 3.4174E-145 630190000 324320000 305880000 126 IPI:IPI00000783.1;IPI:IPI00215824.1 Proteasome subunit beta type-8;Proteasome subunit beta-5i;Proteasome component C13;Macropain subunit C13;Multicatalytic endopeptidase complex subunit C13 PSMB8;LMP7;RING10;Y2 P28062-1;P28062;P28062-2 ENST00000374881;ENST00000374882;ENST00000383116;ENST00000383236 K02740 2 NaN 1.9891 NaN NaN 1.3889 NaN SRF-TF cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;sequence-specific DNA binding;transcription factor activity;transcription regulator activity apoptosis;cell death;metabolic process;muscle organ development;nervous system development;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 2 2 2 4 4 4 55.937 6.2551E-09 2320400 1416800 903580 127 IPI:IPI00000784.1;IPI:IPI00216053.1;IPI:IPI00216051.1;IPI:IPI00216054.1;IPI:IPI00216052.1;IPI:IPI00394659.1 Myocyte-specific enhancer factor 2D MEF2D Q14814-1;Q14814;Q14814-4;Q14814-2;Q14814-5;Q14814-3;Q14814-6 ENST00000340875;ENST00000348159;ENST00000353795;ENST00000368240 K09262 6 1.1434 1.7962 NaN 1.4092 1.2694 NaN Proteasome cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;proteasome core complex;protein complex catalytic activity;endopeptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides;threonine-type endopeptidase activity;threonine-type peptidase activity catabolic process;cellular process;immune response;immune system process;macromolecule catabolic process;metabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Proteasome 5 5 5 30.6 30.6 30.6 23.264 3.9566E-55 49404000 25157000 24247000 128 IPI:IPI00000787.1;IPI:IPI00170899.1 Proteasome subunit beta type-9;Proteasome subunit beta-1i;Proteasome chain 7;Macropain chain 7;Multicatalytic endopeptidase complex chain 7;RING12 protein;Low molecular mass protein 2 PSMB9;LMP2;RING12 P28065-1;P28065;P28065-2 ENST00000374859;ENST00000383114;ENST00000383234 K02741 2 1.0338 1.9553 1.0162 1.3753 1.3392 1.3174 ADH_N;ADH_zinc_N cell part;cytoplasm;intracellular part binding;catalytic activity;ion binding;NADPH:quinone reductase activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor;zinc ion binding cognition;metabolic process;multicellular organismal process;neurological system process;oxidation reduction;sensory perception;sensory perception of light stimulus;system process;visual perception 17 17 17 63.2 63.2 63.2 35.206 1.6309E-165 575070000 282390000 292680000 129 IPI:IPI00000792.1 Quinone oxidoreductase;NADPH:quinone reductase;Zeta-crystallin CRYZ Q08257 ENST00000340866 K00344 1 0.85956 1.5937 0.85522 1.1247 1.0643 1.1003 Proteasome cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;proteasome core complex;protein complex catalytic activity;endopeptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides;threonine-type endopeptidase activity;threonine-type peptidase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Proteasome 8 8 8 39.3 39.3 39.3 25.357 1.615E-198 2329200000 1188600000 1140600000 130 IPI:IPI00000811.2 Proteasome subunit beta type-6;Proteasome delta chain;Macropain delta chain;Multicatalytic endopeptidase complex delta chain;Proteasome subunit Y PSMB6;LMPY P28072 ENST00000270586 K02738 1 0.82124 1.6299 0.83733 1.0639 1.0319 1.1075 14-3-3 cell part;cytoplasmic membrane-bounded vesicle;cytoplasmic part;cytoplasmic vesicle;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;melanosome;membrane-bounded organelle;membrane-bounded vesicle;organelle;vesicle binding;enzyme binding;protein binding biological regulation;cell communication;cellular process;interspecies interaction between organisms;intracellular signaling cascade;multi-organism process;regulation of biological process;regulation of cellular process;signal transduction Cell cycle 24 24 22 70.2 70.2 67.1 29.174 0 13935000000 7233800000 6701700000 131 IPI:IPI00000816.1 14-3-3 protein epsilon YWHAE P62258 ENST00000264335 K06630 1 0.78367 1.7363 0.74758 1.0503 1.147 0.98164 Ribosomal_L16 8 8 8 30.7 30.7 30.7 28.449 4.963E-25 99662000 56188000 43475000 132 IPI:IPI00000821.2 39S ribosomal protein L16, mitochondrial MRPL16;PNAS-111 Q9NX20 ENST00000300151 1 0.71274 1.4022 0.71223 0.96434 0.92907 0.92818 CHDCT2;CHDNT;Chromo;DUF1086;DUF1087;Helicase_C;PHD;SNF2_N cell part;chromatin;chromosomal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;nucleus;organelle;organelle part ATP binding;ATP-dependent DNA helicase activity;binding;catalytic activity;chromatin binding;DNA binding;DNA helicase activity;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding chromatin assembly or disassembly;chromatin organization;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 48 48 38 29.6 29.6 24.5 220.83 0 2207300000 1185000000 1022300000 133 IPI:IPI00455210.1;IPI:IPI00000846.1;IPI:IPI00514825.1 Chromodomain-helicase-DNA-binding protein 4;ATP-dependent helicase CHD4;Mi-2 autoantigen 218 kDa protein;Mi2-beta CHD4 Q14839-2;Q14839;Q14839-1 ENST00000309577;ENST00000357008 3 1.3876 0.55394 1.3242 1.8375 0.3595 1.7676 FERM_M;PH actin filament bundle;actomyosin;adherens junction;cell cortex;cell junction;cell-substrate adherens junction;cell-substrate junction;cytoplasmic part;cytoskeletal part;focal adhesion;intracellular part;membrane part;organelle part;stress fiber binding;protein binding biological adhesion;cell adhesion;cellular component organization;cellular process;cytoskeleton organization;organelle organization;regulation of anatomical structure morphogenesis;regulation of cell morphogenesis;regulation of cell shape 2 2 2 3.4 3.4 3.4 77.86 0.0046845 31367000 6424000 24943000 134 IPI:IPI00000856.7;IPI:IPI00383500.3 Fermitin family homolog 2;Pleckstrin homology domain-containing family C member 1;Kindlin-2;Mitogen-inducible gene 2 protein FERMT2;KIND2;MIG2;PLEKHC1 Q96AC1-1;Q96AC1;Q96AC1-2 ENST00000341590;ENST00000343279;ENST00000395631 2 0.93482 1.9499 1.0389 1.3228 1.2229 1.302 LIM;Nebulin;SH3_1 cortical actin cytoskeleton;cortical cytoskeleton;cytoplasmic part;cytoskeletal part;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle;organelle part binding;ion transmembrane transporter activity;protein binding;SH3/SH2 adaptor activity;signal transducer activity;substrate-specific transmembrane transporter activity;transmembrane transporter activity;transporter activity;zinc ion binding establishment of localization;ion transport;transport 7 7 7 32.6 32.6 32.6 29.717 1.3623E-96 555010000 267670000 287340000 135 IPI:IPI00000861.1;IPI:IPI00386803.4 LIM and SH3 domain protein 1;MLN 50 LASP1;MLN50 Q14847-1;Q14847;Q14847-2 ENST00000318008 2 0.68098 1.2275 0.69688 0.85674 0.85396 0.86697 Anticodon_1;GST_C;GST_N;tRNA-synt_1 aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-oxygen bonds;nucleoside binding;nucleotide binding;purine nucleoside binding;valine-tRNA ligase activity nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;translational elongation;tRNA aminoacylation for protein translation;tRNA metabolic process;valyl-tRNA aminoacylation Aminoacyl-tRNA biosynthesis;Valine, leucine and isoleucine biosynthesis 36 36 36 36.4 36.4 36.4 140.47 0 1814500000 986520000 827960000 136 IPI:IPI00000873.3 Valyl-tRNA synthetase;Valine--tRNA ligase;Protein G7a VARS;G7A;VARS2 P26640 ENST00000211402;ENST00000375663 K01873 1 0.94358 1.8105 0.95364 1.2521 1.1871 1.2679 1-cysPrx_C;AhpC-TSA cytoplasmic membrane-bounded vesicle;cytoplasmic part;cytoplasmic vesicle;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;melanosome;membrane-bounded organelle;membrane-bounded vesicle;nucleus;organelle;vesicle antioxidant activity;binding;catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on peroxide as acceptor;peroxidase activity;peroxiredoxin activity;protein binding catabolic process;cell proliferation;cellular process;metabolic process;oxygen and reactive oxygen species metabolic process;response to oxidative stress;response to reactive oxygen species;response to stress;skeletal system development 24 24 21 76.9 76.9 65.3 22.11 0 38583000000 19949000000 18634000000 137 IPI:IPI00000874.1 Peroxiredoxin-1;Thioredoxin peroxidase 2;Thioredoxin-dependent peroxide reductase 2;Proliferation-associated gene protein;Natural killer cell-enhancing factor A PRDX1;PAGA;PAGB;TDPX2 Q06830 ENST00000262746;ENST00000319248 K03386 1 1.1754 2.3509 1.1615 1.5512 1.5568 1.4863 HSP70 endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;membrane-enclosed lumen;organelle;organelle lumen;organelle part adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding 39 39 39 45.8 45.8 45.8 111.33 0 4260000000 2069800000 2190200000 138 IPI:IPI00000877.1;IPI:IPI00010369.1 Hypoxia up-regulated protein 1;150 kDa oxygen-regulated protein;Orp150 HYOU1;ORP150 Q9Y4L1 ENST00000353883;ENST00000404233 K09486 2 1.9632 3.9574 1.9897 2.5908 2.5015 2.637 BTK;PH;Pkinase_Tyr;SH2;SH3_1 cell part;cytoplasm;intracellular part ATP binding;binding;catalytic activity;non-membrane spanning protein tyrosine kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein tyrosine kinase activity;purine nucleoside binding;zinc ion binding cell communication;cellular process;intracellular signaling cascade;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein kinase cascade;protein modification process;signal transduction T cell receptor signaling pathway 2 2 2 3.2 3.2 3.2 73.58 0.0014035 132150000 63872000 68280000 139 IPI:IPI00000878.4 Tyrosine-protein kinase Tec TEC;PSCTK4 P42680 ENST00000381501 K07364 1 0.56364 1.0234 NaN 0.70385 0.72282 NaN PAM2;zf-CCCH cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;helicase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity;zinc ion binding 4 4 4 2.6 2.6 2.6 219.11 1.524E-22 3891400 2096300 1795100 140 IPI:IPI00000897.3 Probable helicase with zinc finger domain;Down-regulated in human cancers protein HELZ;DRHC;KIAA0054 P42694 ENST00000358691 1 0.36623 0.91011 0.43573 0.48688 0.64272 0.56472 WD40 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle 7 7 7 17 17 17 49.797 8.5268E-70 13282000 7345000 5936700 141 IPI:IPI00000948.3 Transducin beta-like protein 2;WS beta-transducin repeats protein;Williams-Beuren syndrome chromosomal region 13 protein TBL2;WBSCR13;UNQ563/PRO1125 Q9Y4P3 ENST00000305632 1 0.67429 1.385 0.64759 0.86596 0.88881 0.92498 AAA;FtsH_ext;Peptidase_M41 cell part;integral to membrane;intrinsic to membrane;membrane part ATP binding;binding;catalytic activity;endopeptidase activity;metalloendopeptidase activity;metallopeptidase activity;nucleoside binding;nucleotide binding;peptidase activity;protein binding;purine nucleoside binding;zinc ion binding biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis 16 16 16 22.6 22.6 22.6 88.583 2.2805E-145 294450000 155040000 139410000 143 IPI:IPI00001091.4;IPI:IPI00074962.3;IPI:IPI00007834.2;IPI:IPI00305279.4;IPI:IPI00895856.1 AFG3-like protein 2;Paraplegin-like protein AFG3L2 Q9Y4W6 ENST00000269143 K08956 5 0.85784 1.213 0.91648 1.0477 0.84737 1.1532 RRM_1 binding;nucleic acid binding;nucleotide binding;RNA binding cell cycle phase;cell cycle process;cellular process;meiosis 3 3 3 14.3 14.3 14.3 30.503 9.715E-28 46997000 24014000 22982000 145 IPI:IPI00001134.4 RNA-binding protein 7;RNA-binding motif protein 7 RBM7 Q9Y580 ENST00000265882;ENST00000375490 1 0.83639 2.1324 0.74624 1.1318 1.2961 1.0005 Clat_adaptor_s cell part;coated pit;cytoplasmic part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane coat;membrane part;membrane-bounded organelle;organelle;protein complex binding;protein binding;protein transporter activity;substrate-specific transporter activity;transporter activity cellular process;establishment of localization;establishment of localization in cell;establishment of protein localization;intracellular protein transport;intracellular transport;protein transport;transport;vesicle-mediated transport 2 2 2 13.2 13.2 13.2 17.005 6.9705E-05 5563100 3041700 2521500 146 IPI:IPI00001145.1 AP-4 complex subunit sigma-1;Adapter-related protein complex 4 subunit sigma-1;AP-4 adapter complex subunit sigma-1;Sigma-1 subunit of AP-4;Sigma4-adaptin AP4S1 Q9Y587 ENST00000216366;ENST00000313566 K12403 1 0.8854 1.5427 0.8893 1.1311 1.0642 1.1109 LSM cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;small nuclear ribonucleoprotein complex binding;nucleic acid binding;protein binding;RNA binding cellular process;metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA processing;RNA splicing;rRNA processing;tRNA metabolic process;tRNA processing 5 5 5 67.5 67.5 67.5 9.1275 2.195E-24 915280000 491650000 423630000 147 IPI:IPI00001146.1 U6 snRNA-associated Sm-like protein LSm6 LSM6 P62312 ENST00000296581 K04796 1 0.67544 1.4443 0.6868 0.89542 0.93465 0.91828 HEAT cell part;cytoplasmic part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome binding;nucleic acid binding;protein binding;translation factor activity, nucleic acid binding;translation regulator activity posttranscriptional regulation of gene expression;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of metabolic process;regulation of translation 66 66 66 30.8 30.8 30.8 292.74 0 1288700000 682780000 605920000 148 IPI:IPI00001159.10 Translational activator GCN1;GCN1-like protein 1 GCN1L1;KIAA0219 Q92616 ENST00000300648 1 NaN 1.3007 0.51337 NaN 0.84042 0.74047 3 3 3 15.1 15.1 15.1 39.42 3.2252E-12 5326100 3158100 2167900 149 IPI:IPI00001287.1 Uncharacterized protein C20orf72 C20orf72 Q9BQP7 ENST00000377710 1 0.58216 1.1723 0.58569 0.73009 0.74997 0.78158 GCFC cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;transcription factor activity;transcription regulator activity biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 4 4 4 4.8 4.8 4.8 104.8 6.5087E-28 17843000 10066000 7776800 150 IPI:IPI00001364.2;IPI:IPI00069267.2 GC-rich sequence DNA-binding factor homolog GCFC;C21orf66 Q9Y5B6-1;Q9Y5B6;Q9Y5B6-2 ENST00000290178;ENST00000331923;ENST00000342419 2 0.96715 0.94264 NaN 1.2225 0.63897 NaN Filament;Filament_head cell part;cytoskeletal part;intermediate filament;intracellular organelle part;intracellular part;neurofilament;organelle part structural constituent of cytoskeleton;structural molecule activity anatomical structure development;cell differentiation;cellular developmental process;cellular process;developmental process;nervous system development;system development 3 1 1 4.4 2 2 55.39 6.1814E-17 5757700 2728300 3029500 152 IPI:IPI00001453.2 Alpha-internexin;66 kDa neurofilament protein;Neurofilament-66 INA;NEF5 Q16352 ENST00000369849 K07608 1 0.43102 1.1271 NaN 0.55441 0.79102 NaN Rod_C condensed chromosome kinetochore;cytoplasm;intracellular organelle;kinetochore;kinetochore microtubule;macromolecular complex;membrane-bounded organelle;microtubule;non-membrane-bounded organelle;nucleus;organelle;spindle microtubule;spindle pole binding;protein binding cell cycle checkpoint;cellular process;mitosis;mitotic cell cycle checkpoint;nuclear division;organelle organization;protein complex assembly;regulation of exit from mitosis;regulation of mitosis;regulation of mitotic cell cycle 8 8 8 3.8 3.8 3.8 250.75 9.1475E-24 17833000 9712900 8120300 153 IPI:IPI00001458.1 Kinetochore-associated protein 1;Rough deal homolog KNTC1;KIAA0166 P50748 ENST00000333479 K11577 1 0.7867 1.7716 0.80061 1.0616 1.1524 1.0547 zf-Tim10_DDP intracellular part;macromolecular complex;membrane;mitochondrial inner membrane;mitochondrial intermembrane space protein transporter complex;mitochondrial membrane;organelle inner membrane;organelle membrane;organelle part;protein complex binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding intracellular protein transport;mitochondrial membrane organization;mitochondrial transport;mitochondrion organization;organelle organization;protein targeting;protein targeting to membrane;protein targeting to mitochondrion;transport 4 4 4 40.8 40.8 40.8 11.586 6.0645E-153 29172000 15030000 14142000 154 IPI:IPI00001538.3 Mitochondrial import inner membrane translocase subunit Tim9 B;TIMM10B;Fracture callus protein 1;FxC1 FXC1;TIM9B;TIMM9B Q9Y5J6 ENST00000254616 1 0.78641 1.7612 0.88835 1.0012 1.1501 1.1529 Thiolase_C;Thiolase_N acetyl-CoA C-acyltransferase activity;acyltransferase activity;C-acyltransferase activity;catalytic activity;transferase activity;transferase activity, transferring acyl groups;transferase activity, transferring acyl groups other than amino-acyl groups alcohol metabolic process;cholesterol biosynthetic process;cholesterol metabolic process;fatty acid metabolic process;lipid metabolic process;metabolic process;organic acid metabolic process;steroid biosynthetic process;steroid metabolic process Benzoate degradation via hydroxylation;Fatty acid elongation in mitochondria;Fatty acid metabolism;Valine, leucine and isoleucine degradation 5 5 5 17.9 17.9 17.9 41.924 1.2257E-54 130310000 69945000 60364000 155 IPI:IPI00001539.8 3-ketoacyl-CoA thiolase, mitochondrial;Beta-ketothiolase;Acetyl-CoA acyltransferase;Mitochondrial 3-oxoacyl-CoA thiolase;T1 ACAA2 P42765 ENST00000285093;ENST00000398549 K07508 1 0.62353 1.5563 0.7107 0.86057 0.94859 1.025 zf-Tim10_DDP cytoplasmic part;intracellular part;macromolecular complex;membrane part;mitochondrial inner membrane presequence translocase complex;mitochondrial intermembrane space protein transporter complex;mitochondrial part;organelle part;protein complex binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding intracellular protein transport;mitochondrial membrane organization;mitochondrial transport;mitochondrion organization;organelle organization;protein targeting;protein targeting to membrane;protein targeting to mitochondrion;system process;transport 4 4 4 52.8 52.8 52.8 10.378 3.7374E-94 409690000 220150000 189540000 156 IPI:IPI00001541.1 Mitochondrial import inner membrane translocase subunit Tim9 TIMM9;TIM9;TIM9A;TIMM9A Q9Y5J7 ENST00000216463;ENST00000395159;ENST00000407021 1 0.74178 1.4228 NaN 1.0047 0.87054 NaN zf-Tim10_DDP cytoplasmic part;intracellular part;macromolecular complex;membrane part;mitochondrial inner membrane presequence translocase complex;mitochondrial intermembrane space protein transporter complex;mitochondrial part;organelle part;protein complex binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding intracellular protein transport;mitochondrial membrane organization;mitochondrial transport;mitochondrion organization;organelle organization;protein targeting;protein targeting to membrane;protein targeting to mitochondrion;system process;transport 2 2 2 31.1 31.1 31.1 10.333 1.2378E-08 40966000 21411000 19555000 157 IPI:IPI00001543.1 Mitochondrial import inner membrane translocase subunit Tim10 TIMM10;TIM10 P62072 ENST00000257245 1 0.6507 1.0124 0.67653 0.79583 0.72298 0.83317 zf-Tim10_DDP cytoplasmic part;intracellular part;macromolecular complex;membrane part;mitochondrial inner membrane presequence translocase complex;mitochondrial intermembrane space protein transporter complex;mitochondrial part;organelle part;protein complex binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding intracellular protein transport;mitochondrial membrane organization;mitochondrial transport;mitochondrion organization;organelle organization;protein targeting;protein targeting to membrane;protein targeting to mitochondrion;system process;transport 2 2 2 22.4 22.4 22.4 11.155 6.2513E-44 99192000 52623000 46569000 158 IPI:IPI00001546.2 Mitochondrial import inner membrane translocase subunit Tim8 B;Deafness dystonia protein 2;DDP-like protein TIMM8B;DDP2;DDPL;TIM8B Q9Y5J9 ENST00000280354 1 2.573 4.5791 2.481 3.083 3.0109 2.9992 Ank cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cyclin-dependent protein kinase inhibitor activity;cyclin-dependent protein kinase regulator activity;enzyme inhibitor activity;kinase inhibitor activity;kinase regulator activity;protein binding;protein kinase inhibitor activity cell cycle arrest;G1/S transition of mitotic cell cycle;induction of apoptosis;negative regulation of cell proliferation;negative regulation of metabolic process;regulation of cell growth;regulation of cyclin-dependent protein kinase activity Cell cycle 2 2 2 7.7 7.7 7.7 18.127 2.879E-11 36808000 14207000 22601000 159 IPI:IPI00001564.1 Cyclin-dependent kinase 4 inhibitor C;p18-INK4c;Cyclin-dependent kinase 6 inhibitor;p18-INK6 CDKN2C;CDKN6 P42773 ENST00000262662;ENST00000371761;ENST00000396148 K06622 1 0.9395 1.9214 1.0643 1.2427 1.3394 1.3697 ATP-synt_D macromolecular complex;protein complex;proton-transporting two-sector ATPase complex;proton-transporting two-sector ATPase complex, catalytic domain;proton-transporting V-type ATPase complex;vacuolar proton-transporting V-type ATPase complex binding;catalytic activity;cation transmembrane transporter activity;hydrogen ion transmembrane transporter activity;ion transmembrane transporter activity;monovalent inorganic cation transmembrane transporter activity;protein binding;transporter activity ATP biosynthetic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;transport Epithelial cell signaling in Helicobacter pylori infection;Oxidative phosphorylation;Vibrio cholerae infection 7 7 7 32.8 32.8 32.8 28.262 3.9903E-98 396800000 265920000 130890000 160 IPI:IPI00001568.1 V-type proton ATPase subunit D;Vacuolar proton pump subunit D;V-ATPase 28 kDa accessory protein ATP6V1D;ATP6M;VATD Q9Y5K8 ENST00000216442 K02149 1 0.68829 1.096 0.66738 0.82907 0.75 0.82242 zf-Tim10_DDP cytoplasmic part;intracellular part;macromolecular complex;membrane part;mitochondrial inner membrane presequence translocase complex;mitochondrial intermembrane space protein transporter complex;mitochondrial part;organelle part;protein complex binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding intracellular protein transport;mitochondrial membrane organization;mitochondrial transport;mitochondrion organization;organelle organization;protein targeting;protein targeting to membrane;protein targeting to mitochondrion;system process;transport 4 4 4 45.3 45.3 45.3 10.5 3.131E-75 287500000 154210000 133290000 163 IPI:IPI00001589.1 Mitochondrial import inner membrane translocase subunit Tim13 TIMM13;TIM13B;TIMM13A;TIMM13B Q9Y5L4 ENST00000215570 1 0.90992 1.2833 0.91107 1.1625 0.92941 1.1799 Peptidase_S28 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;lysosome;lytic vacuole;membrane-bounded organelle;organelle;vacuole carboxypeptidase activity;catalytic activity;exopeptidase activity;hydrolase activity;peptidase activity;serine hydrolase activity;serine-type carboxypeptidase activity;serine-type exopeptidase activity;serine-type peptidase activity biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis 7 7 7 18.5 18.5 18.5 55.799 1.0237E-21 66579000 30219000 36360000 164 IPI:IPI00001593.1 Lysosomal Pro-X carboxypeptidase;Prolylcarboxypeptidase;Proline carboxypeptidase;Angiotensinase C;Lysosomal carboxypeptidase C PRCP;PCP P42785 ENST00000313010;ENST00000393399 K01285 1 0.83171 1.4341 0.87784 1.069 0.95788 1.091 Atx10homo_assoc cell part;cell projection;cell soma;cytoplasmic part;dendrite;intracellular part;neuron projection;perinuclear region of cytoplasm binding;protein binding anatomical structure development;cell death;cellular process;death;developmental process;nervous system development;system development 20 20 20 55.6 55.6 55.6 53.488 0 776060000 399640000 376420000 165 IPI:IPI00001636.1 Ataxin-10;Spinocerebellar ataxia type 10 protein;Brain protein E46 homolog ATXN10;SCA10 Q9UBB4 ENST00000252934;ENST00000381061 1 0.7286 1.4485 0.75392 0.96141 0.99164 0.95097 Arm;HEAT;IBN_N cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;nucleoplasm;organelle part;pore complex;protein complex binding;cation binding;ion binding;metal ion binding;nuclear localization sequence binding;peptide binding;protein binding;protein domain specific binding;signal sequence binding;transition metal ion binding;zinc ion binding intracellular protein transport;NLS-bearing substrate import into nucleus;protein complex assembly;protein import into nucleus;protein import into nucleus, docking;protein import into nucleus, translocation;protein targeting;transport 32 32 32 46.5 46.5 46.5 97.169 0 5521000000 2927600000 2593400000 166 IPI:IPI00001639.2 Importin subunit beta-1;Karyopherin subunit beta-1;Nuclear factor P97;Importin-90 KPNB1;NTF97 Q14974 ENST00000290158 1 0.67095 1.1448 0.63335 0.88751 0.7907 0.83201 DUF667 developmental process;multicellular organismal development;multicellular organismal process 6 6 6 24.4 24.4 24.4 22.774 3.5628E-17 150860000 81388000 69475000 169 IPI:IPI00001655.1 UPF0468 protein C16orf80;Transcription factor IIB C16orf80 Q9Y6A4 ENST00000262498 1 0.80627 1.4809 0.85419 1.0365 1.0178 1.1295 NPL4;zf-NPL4 cell part;cytoplasmic part;cytosol;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane part;membrane-bounded organelle;nuclear envelope-endoplasmic reticulum network;nucleus;organelle binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding catabolic process;Golgi organization;macromolecule catabolic process;membrane fusion;metabolic process;misfolded or incompletely synthesized protein catabolic process;organelle organization;proteolysis;ubiquitin-dependent protein catabolic process 15 15 15 28.2 28.2 28.2 69.46 2.4405E-195 277750000 145140000 132610000 171 IPI:IPI00001676.9;IPI:IPI00290543.5 Nuclear protein localization protein 4 homolog NPLOC4;KIAA1499;NPL4 Q8TAT6-2;Q8TAT6;Q8TAT6-1 ENST00000331134;ENST00000374747 2 0.664 1.6588 0.67306 0.94581 0.98498 0.85314 Bromodomain cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;histone binding;protein binding;transcription factor binding cell communication;cell surface receptor linked signal transduction;cellular process;regulation of biosynthetic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;signal transduction 2 2 2 3.8 3.8 3.8 74.266 0.00010088 13595000 7787200 5808200 172 IPI:IPI00647008.1;IPI:IPI00001707.4 Bromodomain-containing protein 7;75 kDa bromodomain protein;Protein CELTIX-1 BRD7;BP75;CELTIX1 Q9NPI1-2;Q9NPI1;Q9NPI1-1 ENST00000299197;ENST00000394688;ENST00000394689 K11723 2 0.7479 1.1377 0.62054 0.93329 0.81095 0.75495 Vps51 cell part;cytoplasmic part;Golgi apparatus;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane part;membrane-bounded organelle;organelle establishment of localization;establishment of protein localization;lipid transport;protein transport;transport 9 9 9 14.5 14.5 14.5 86.041 1.4039E-43 41661000 22014000 19647000 173 IPI:IPI00001710.3;IPI:IPI00607717.1 Protein fat-free homolog;Another new gene 2 protein FFR;ANG2;C11orf2;PP5382 Q9UID3-1;Q9UID3;Q9UID3-2 ENST00000279281 2 0.76439 1.4585 0.61811 1.0001 0.92209 0.81776 PseudoU_synth_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle carbon-oxygen lyase activity;catalytic activity;hydro-lyase activity;intramolecular transferase activity;isomerase activity;lyase activity;pseudouridine synthase activity;pseudouridylate synthase activity cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;pseudouridine synthesis;RNA modification;RNA processing;tRNA metabolic process;tRNA processing 16 16 16 46.4 46.4 46.4 47.47 1.5847E-115 203670000 110460000 93212000 174 IPI:IPI00619930.2;IPI:IPI00001716.5 tRNA pseudouridine synthase A;tRNA-uridine isomerase I;tRNA pseudouridylate synthase I PUS1;PP8985 Q9Y606-1;Q9Y606;Q9Y606-2 ENST00000322060;ENST00000376649 K06173 2 0.62249 0.90037 NaN 0.78396 0.61676 NaN HHH;HhH-GPD cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;catalytic activity;DNA binding;DNA-(apurinic or apyrimidinic site) lyase activity;double-stranded DNA binding;nucleic acid binding;oxidized base lesion DNA N-glycosylase activity;oxidized pyrimidine base lesion DNA N-glycosylase activity alcohol metabolic process;carbohydrate metabolic process;DNA catabolic process, endonucleolytic;D-ribose metabolic process;monosaccharide metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Base excision repair 3 3 3 10.9 10.9 10.9 34.389 1.815E-15 12781000 6819900 5960600 175 IPI:IPI00001722.1 Endonuclease III-like protein 1 NTHL1;NTH1;OCTS3 P78549 ENST00000219066 K10773 1 0.64489 1.3132 NaN 0.80593 0.84387 NaN FH2 cell part;cytoplasm;cytoskeleton;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle actin binding;binding;cytoskeletal protein binding;protein binding actin cytoskeleton organization;actin filament-based process;cellular component organization;cellular process;cytoskeleton organization;organelle organization 5 5 5 6.4 6.4 6.4 126.55 1.0651E-19 11965000 6369900 5595400 176 IPI:IPI00001730.3 FH1/FH2 domain-containing protein 1;Formin homolog overexpressed in spleen 1;Formin homology 2 domain-containing protein 1 FHOD1;FHOS;FHOS1 Q9Y613 ENST00000258201 1 0.83598 1.4473 0.85885 1.026 0.99565 1.0533 Myb_DNA-binding cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;Notch binding;nucleic acid binding;protein binding;receptor binding;transcription cofactor activity;transcription corepressor activity;transcription factor binding;transcription regulator activity;transcription repressor activity negative regulation of transcription from RNA polymerase II promoter;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 17 17 17 9.5 9.5 9.5 274.8 3.3947E-45 486700000 254830000 231860000 177 IPI:IPI00001735.6;IPI:IPI00923596.1;IPI:IPI00923436.1;IPI:IPI00923531.1;IPI:IPI00878336.2 Nuclear receptor corepressor 2;Silencing mediator of retinoic acid and thyroid hormone receptor;Thyroid-, retinoic-acid-receptor-associated corepressor;T3 receptor-associating factor;CTG repeat protein 26;SMAP270 NCOR2;CTG26 Q9Y618-1;Q9Y618;Q9Y618-3;Q9Y618-4;Q9Y618-5 ENST00000356219;ENST00000397355;ENST00000405201 5 0.53435 1.2816 0.43128 0.71916 0.85476 0.56161 Nup88 cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;organelle part;pore complex;protein complex transporter activity cellular process;establishment of protein localization;intracellular protein transport;intracellular transport;mRNA transport;nucleic acid transport;nucleobase, nucleoside, nucleotide and nucleic acid transport;protein transport;RNA transport;transport 6 6 6 11.2 11.2 11.2 83.541 6.3408E-43 74698000 44609000 30089000 178 IPI:IPI00001738.4 Nuclear pore complex protein Nup88;Nucleoporin Nup88;88 kDa nuclear pore complex protein NUP88 Q99567 ENST00000225696 1 0.79594 1.4916 0.82289 1.0447 0.97904 1.0619 RRM_1 cell part;cytoplasm;exon-exon junction complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex;ribonucleoprotein complex;spliceosomal complex binding;mRNA binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding nuclear mRNA splicing, via spliceosome;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 3 3 3 21.8 21.8 21.8 19.889 9.4655E-66 417640000 219990000 197650000 179 IPI:IPI00001757.1;IPI:IPI00216659.1 RNA-binding protein 8A;RNA-binding motif protein 8A;Ribonucleoprotein RBM8A;RNA-binding protein Y14;Binder of OVCA1-1 RBM8A;RBM8;HSPC114;MDS014 Q9Y5S9-1;Q9Y5S9;Q9Y5S9-2 ENST00000330165 2 0.59312 1.2359 0.56187 0.7459 0.74358 0.75525 UCH cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part catalytic activity;cysteine-type peptidase activity;hydrolase activity;hydrolase activity, acting on ester bonds;peptidase activity;peptidase activity, acting on L-amino acid peptides;thiolester hydrolase activity;ubiquitin thiolesterase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process 10 10 10 13.8 13.8 13.8 122.91 2.0463E-60 102270000 54148000 48123000 180 IPI:IPI00001786.5;IPI:IPI00843790.1 Ubiquitin carboxyl-terminal hydrolase 36;Ubiquitin thioesterase 36;Ubiquitin-specific-processing protease 36;Deubiquitinating enzyme 36 USP36;KIAA1453 Q9P275-2;Q9P275;Q9P275-1 ENST00000312010 K11855 2 0.45937 2.1272 NaN 0.6038 1.3579 NaN PX binding;lipid binding;phosphoinositide binding;phospholipid binding;protein binding cell communication;cellular process;establishment of localization;establishment of protein localization;protein transport;transport 5 5 5 14 14 14 52.569 7.3742E-15 9561900 4978500 4583400 183 IPI:IPI00001885.1 Sorting nexin-8 SNX8 Q9Y5X2 ENST00000222990 1 0.68534 NaN 0.58971 0.90081 NaN 0.7522 CUE endoplasmic reticulum membrane;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane;membrane-bounded organelle;nucleus;organelle;organelle membrane;organelle part binding;protein binding catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 3 3 3 7.1 7.1 7.1 53.028 2.003E-13 28996000 18007000 10989000 184 IPI:IPI00001891.1;IPI:IPI00215815.3;IPI:IPI00917463.1 Ancient ubiquitous protein 1 AUP1 Q9Y679-1;Q9Y679;Q9Y679-2;Q9Y679-3 ENST00000258081;ENST00000377526 3 1.0186 1.6441 1.1138 1.2144 1.1581 1.3894 Endonuclease_NS extracellular region binding;catalytic activity;cation binding;endonuclease activity;hydrolase activity;hydrolase activity, acting on ester bonds;ion binding;metal ion binding;nuclease activity;nucleic acid binding Apoptosis 3 3 3 5.8 5.8 5.8 55.016 4.2563E-09 53256000 24035000 29221000 186 IPI:IPI00001952.5 Endonuclease domain-containing 1 protein ENDOD1;KIAA0830 O94919 ENST00000278505 K01173 1 0.69712 1.6716 0.77667 0.94645 1.0656 1.0197 actin cytoskeleton;cell fraction;cell projection;cytoplasmic vesicle membrane;cytoskeleton;integral to membrane;intrinsic to membrane;membrane;microvillus;nucleus;organelle;organelle membrane;plasma membrane;soluble fraction;vesicle membrane anion channel activity;binding;chloride channel activity;ion channel activity;protein binding;transporter activity;voltage-gated anion channel activity;voltage-gated chloride channel activity;voltage-gated ion channel activity anion transport;cell differentiation;cellular process;chloride transport;developmental process;inorganic anion transport;ion transport;negative regulation of cell migration;regulation of cell migration;regulation of localization;transport 8 7 7 36.8 34.4 34.4 28.772 1.2538E-95 64271000 35685000 28586000 187 IPI:IPI00001960.4 Chloride intracellular channel protein 4;Intracellular chloride ion channel protein p64H1 CLIC4 Q9Y696 ENST00000374379 K05024 1 0.52515 0.98553 NaN 0.73399 0.67268 NaN Pep3_Vps18 cell part;cytoplasmic part;endosomal part;endosome membrane;intracellular organelle part;intracellular part;late endosome membrane;lysosomal membrane;membrane;organelle membrane;organelle part;vacuolar membrane;vacuolar part binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding establishment of localization;establishment of protein localization;protein transport;transport 8 8 8 12.3 12.3 12.3 110.18 4.1743E-13 49058000 26468000 22590000 188 IPI:IPI00001985.2;IPI:IPI00333553.3 Vacuolar protein sorting-associated protein 18 homolog VPS18;KIAA1475 Q9P253-1;Q9P253;Q9P253-2 ENST00000220509 2 0.80378 1.6908 0.86592 1.0317 1.0983 1.063 Proteasom_PSMB cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;proteasome complex;protein complex binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process 23 23 23 53.8 53.8 53.8 56.195 0 1028300000 544290000 484040000 189 IPI:IPI00002134.4 26S proteasome non-ATPase regulatory subunit 5;26S proteasome subunit S5B;26S protease subunit S5 basic PSMD5;KIAA0072 Q16401 ENST00000210313 K06692 1 0.97402 1.7601 0.94821 1.2946 1.1094 1.2599 TACC cell part;cytoplasm;intracellular part 14 14 14 24.5 24.5 24.5 90.359 7.8121E-154 325860000 162050000 163810000 190 IPI:IPI00002135.1 Transforming acidic coiled-coil-containing protein 3;ERIC-1 TACC3;ERIC1 Q9Y6A5 ENST00000313288 1 0.85506 1.7167 0.89014 1.0712 1.102 1.177 Arf cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;Golgi apparatus part;Golgi cisterna membrane;Golgi membrane;intracellular organelle part;intracellular part;membrane;membrane part;organelle membrane;organelle part binding;cation binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;ion binding;magnesium ion binding;metal ion binding;nucleotide binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cellular component organization;cellular process;ER to Golgi vesicle-mediated transport;establishment of protein localization;intracellular protein transport;membrane organization;protein transport;transport;vesicle-mediated transport 6 4 4 40.9 29.8 29.8 22.41 3.3717E-51 46363000 24389000 21974000 191 IPI:IPI00002149.1 GTP-binding protein SAR1b SAR1B;SARA2;SARB Q9Y6B6 ENST00000282606;ENST00000394992;ENST00000402673 K07954 1 0.64989 1.347 0.56185 0.86593 0.87688 0.70042 Adaptin_N;B2-adapt-app_C AP-type membrane coat adaptor complex;cell fraction;clathrin adaptor complex;cytoplasmic part;Golgi apparatus part;intracellular part;macromolecular complex;membrane part;organelle part;protein complex;soluble fraction;trans-Golgi network binding;protein binding;protein transporter activity;substrate-specific transporter activity;transporter activity cellular process;establishment of localization;establishment of localization in cell;establishment of protein localization;intracellular protein transport;intracellular transport;protein transport;transport;vesicle-mediated transport 4 4 4 6 6 6 83.259 6.2278E-21 26253000 15552000 10702000 192 IPI:IPI00002150.4 AP-4 complex subunit beta-1;Adapter-related protein complex 4 subunit beta-1;AP-4 adapter complex subunit beta;Beta subunit of AP-4;Beta4-adaptin AP4B1 Q9Y6B7 ENST00000256658;ENST00000369569;ENST00000369571 K12401 1 0.85992 1.8522 0.87319 1.0854 1.1727 1.177 DUF1981;Sec7 cell part;cytoplasmic part;cytosol;Golgi apparatus part;Golgi membrane;intracellular organelle part;intracellular part;membrane;organelle membrane;organelle part ARF guanyl-nucleotide exchange factor activity;enzyme regulator activity;GTPase regulator activity;guanyl-nucleotide exchange factor activity;nucleoside-triphosphatase regulator activity;small GTPase regulator activity cell communication;cellular process;exocytosis;intracellular signaling cascade;regulation of ARF protein signal transduction;regulation of cell communication;regulation of signal transduction;signal transduction;transport;vesicle-mediated transport 15 15 6 10.8 10.8 4.5 202.04 3.4236E-157 72297000 37531000 34766000 193 IPI:IPI00002186.5 Brefeldin A-inhibited guanine nucleotide-exchange protein 2 ARFGEF2;ARFGEP2;BIG2 Q9Y6D5 ENST00000371917 1 1.0205 1.4868 NaN 1.2749 0.96339 NaN DUF1981;Sec7 cell part;intracellular ARF guanyl-nucleotide exchange factor activity;binding;cytoskeletal protein binding;enzyme regulator activity;GTPase regulator activity;guanyl-nucleotide exchange factor activity;myosin binding;protein binding;small GTPase regulator activity cellular process;exocytosis;regulation of ARF protein signal transduction;regulation of cell communication;regulation of Ras protein signal transduction;regulation of signal transduction;secretion;secretion by cell;transport;vesicle-mediated transport 15 6 6 9.7 3.7 3.7 208.76 1.0592E-133 31017000 16324000 14693000 194 IPI:IPI00002188.2 Brefeldin A-inhibited guanine nucleotide-exchange protein 1;p200 ARF-GEP1;p200 ARF guanine nucleotide exchange factor ARFGEF1;ARFGEP1;BIG1 Q9Y6D6 ENST00000262215 1 0.77501 1.4404 0.79052 1.0417 0.95226 1.0222 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding cell cycle;DNA metabolic process;DNA repair;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of cyclin-dependent protein kinase activity;response to DNA damage stimulus;response to stress 9 9 2 37.3 37.3 6.7 35.979 4.2358E-303 381150000 199850000 181300000 195 IPI:IPI00002203.6;IPI:IPI00786906.1 BRCA2 and CDKN1A-interacting protein;Protein TOK-1;P21- and CDK-associated protein 1 BCCIP;TOK1 Q9P287-1;Q9P287;Q9P287-3 ENST00000278100;ENST00000368759;ENST00000392718 2 0.83826 1.788 0.84364 1.0991 1.1842 1.0734 Pkinase cell part;cytoplasm;intracellular part ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cell communication;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process;signal transduction 18 18 9 36.7 36.7 21.6 49.997 0 581880000 308390000 273490000 196 IPI:IPI00909904.1;IPI:IPI00002212.1 Serine/threonine-protein kinase 24;STE20-like kinase MST3;Mammalian STE20-like protein kinase 3 STK24;MST3;STK3 Q9Y6E0-2;Q9Y6E0;Q9Y6E0-1 ENST00000376547;ENST00000376554;ENST00000397517 2 1.0823 1.9504 1.1406 1.3607 1.3278 1.4181 Arm;IBB cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;nucleoplasm;organelle part;pore complex;protein complex binding;nuclear localization sequence binding;peptide binding;protein binding;protein transporter activity;signal sequence binding;substrate-specific transporter activity;transporter activity DNA metabolic process;G2 phase of mitotic cell cycle;M phase specific microtubule process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein import into nucleus;protein targeting;regulation of DNA recombination 20 20 20 48.8 48.8 48.8 57.861 0 1526400000 766790000 759650000 197 IPI:IPI00002214.1;IPI:IPI00873236.2 Importin subunit alpha-2;Karyopherin subunit alpha-2;SRP1-alpha;RAG cohort protein 1 KPNA2;RCH1;SRP1 P52292 ENST00000330459;ENST00000400873 2 0.63287 1.1479 0.43326 0.79749 0.81493 0.521 cell part;histone acetyltransferase complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;SAGA-type complex;STAGA complex binding;protein binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding;transcription regulator activity chromatin organization;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein amino acid acetylation;protein modification process;regulation of transcription, DNA-dependent;transcription 2 2 2 1.9 1.9 1.9 113.97 1.5793E-05 6366500 3498200 2868300 198 IPI:IPI00002220.4;IPI:IPI00748953.2 Histone deacetylase complex subunit SAP130;130 kDa Sin3-associated polypeptide;Sin3-associated polypeptide p130 SAP130 Q9H0E3-2;Q9H0E3;Q9H0E3-1 ENST00000259234;ENST00000259235 2 0.36 0.87348 0.43463 0.50075 0.55549 0.58948 Pkinase cell part;cytoplasm;cytoplasmic vesicle membrane;integral to membrane;intracellular organelle;intracellular part;intrinsic to membrane;membrane;non-membrane-bounded organelle;nucleolus;organelle;organelle membrane;vesicle membrane ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cellular biopolymer metabolic process;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process MAPK signaling pathway 2 1 1 2.2 0.9 0.9 116.07 0.0025693 10671000 6807400 3863500 199 IPI:IPI00002232.2;IPI:IPI00654673.2;IPI:IPI00465168.4;IPI:IPI00641071.3;IPI:IPI00006283.3 Serine/threonine-protein kinase TAO1;Thousand and one amino acid protein 1;STE20-like kinase PSK2;Kinase from chicken homolog B;Serine/threonine-protein kinase TAO2;Thousand and one amino acid protein 2;Prostate-derived STE20-like kinase 1;Kinase from chicken homolog C TAOK1;KIAA1361;MAP3K16;TAOK2;KIAA0881;MAP3K17;PSK;PSK1;UNQ2971/PRO7431 Q7L7X3-1;Q7L7X3;Q7L7X3-2;Q9UL54-1;Q9UL54;Q9UL54-3;Q9UL54-2 ENST00000261716;ENST00000279394;ENST00000308893 K04429 5 0.70896 1.5913 0.81169 0.94143 1.0488 1.0032 EGF;F5_F8_type_C cell part;cytoplasm;intracellular part biological adhesion;cell adhesion;cellular process;fertilization;interspecies interaction between organisms;multi-organism process;reproductive process;single fertilization 7 7 7 25.8 25.8 25.8 43.122 9.4049E-133 109730000 62643000 47087000 200 IPI:IPI00002236.3 Lactadherin;Milk fat globule-EGF factor 8;HMFG;Breast epithelial antigen BA46;MFGM;Lactadherin short form;Medin MFGE8 Q08431 ENST00000268150 1 0.91994 1.6887 NaN 1.1445 1.0996 NaN 4 4 4 9.1 9.1 9.1 39.499 6.401E-09 7333100 4186700 3146300 201 IPI:IPI00002240.1 Protein FAM118B FAM118B Q9BPY3 ENST00000360194 1 0.52896 0.97025 0.50481 0.68066 0.65486 0.66738 Beach;DUF1088;WD40 binding;protein binding 29 29 1 12.6 12.6 0.6 319.1 0 431610000 244290000 187320000 202 IPI:IPI00002255.5;IPI:IPI00328195.5 Lipopolysaccharide-responsive and beige-like anchor protein;CDC4-like protein;Beige-like protein LRBA;BGL;CDC4L;LBA P50851-1;P50851 ENST00000357115 2 0.69221 1.7451 0.6771 0.99382 1.0221 1.0652 DUF89 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding 11 11 11 22.7 22.7 22.7 51.172 1.7565E-124 292770000 162990000 129780000 203 IPI:IPI00002270.3 UPF0364 protein C6orf211 C6orf211 Q9H993 ENST00000367294 1 NaN 1.2633 NaN NaN 0.89448 NaN Peptidase_M76 cell part;DNA-dependent protein kinase-DNA ligase 4 complex;intracellular organelle part;intracellular part;macromolecular complex;nonhomologous end joining complex;nuclear part;organelle part;protein complex binding;catalytic activity;DNA-dependent protein kinase activity;kinase activity;metallopeptidase activity;peptidase activity;protein kinase activity;protein serine/threonine kinase activity;transferase activity;zinc ion binding DNA metabolic process;DNA repair;double-strand break repair;double-strand break repair via nonhomologous end joining;non-recombinational repair;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;proteolysis 2 2 2 7.7 7.7 7.7 28.08 1.4269E-05 2137700 1290000 847640 204 IPI:IPI00002288.5 Mitochondrial inner membrane protease ATP23 homolog;XRCC6-binding protein 1;Ku70-binding protein 3 XRCC6BP1;KUB3 Q9Y6H3 ENST00000300145 1 0.75575 1.441 0.77922 0.94099 0.93107 0.99544 RmlD_sub_bind cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;methionine adenosyltransferase complex;nucleus;organelle;protein complex binding;catalytic activity;dTDP-4-dehydrorhamnose reductase activity;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;protein binding carbohydrate metabolic process;cellular amino acid and derivative metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;polysaccharide biosynthetic process;polysaccharide metabolic process Methionine metabolism;Selenoamino acid metabolism 12 12 12 43.7 43.7 43.7 37.551 1.2201E-255 714700000 373300000 341400000 205 IPI:IPI00002324.6;IPI:IPI00181717.5;IPI:IPI00845510.1;IPI:IPI00845294.1;IPI:IPI00845444.1 Methionine adenosyltransferase 2 subunit beta;Methionine adenosyltransferase II beta;Methionine adenosyltransferase 2 beta subunit;DTDP-4-keto-6-deoxy-D-glucose 4-reductase MAT2B;TGR;MSTP045;Nbla02999;UNQ2435/PRO4995 Q9NZL9-1;Q9NZL9;Q9NZL9-2;Q9NZL9-4;Q9NZL9-3 ENST00000280969;ENST00000321757;ENST00000393908 K00789 5 0.51358 0.77961 NaN 0.68189 0.53981 NaN DNA_pol_lambd_f cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;DNA binding;DNA nucleotidylexotransferase activity;DNA-directed DNA polymerase activity;magnesium ion binding;nucleic acid binding;transferase activity;transferase activity, transferring phosphorus-containing groups biosynthetic process;cellular process;DNA metabolic process;DNA replication;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Non-homologous end-joining 2 2 2 5.3 5.3 5.3 54.815 2.3331E-05 1706400 876510 829920 206 IPI:IPI00002325.1 DNA polymerase mu POLM Q9NP87 ENST00000242248;ENST00000395831 K03513 1 0.5613 1.0085 0.80944 0.7323 0.64797 1.001 UCH;zf-UBP binding;catalytic activity;cysteine-type peptidase activity;hydrolase activity;hydrolase activity, acting on ester bonds;peptidase activity;ubiquitin thiolesterase activity;ubiquitin-specific protease activity;zinc ion binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process 5 5 5 11 11 11 58.896 3.9048E-58 48236000 25074000 23162000 207 IPI:IPI00002330.2 Ubiquitin carboxyl-terminal hydrolase 3;Ubiquitin thioesterase 3;Ubiquitin-specific-processing protease 3;Deubiquitinating enzyme 3 USP3 Q9Y6I4 ENST00000380324 K11986 1 0.5159 0.96644 0.36377 0.68589 0.66653 0.51971 HEAT cell fraction;cell part;cytoplasmic part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle;soluble fraction binding;cytoskeletal protein binding;microtubule binding;protein binding;transcription cofactor activity;transcription corepressor activity;transcription factor binding;transcription repressor activity;transporter activity;tubulin binding induction of apoptosis;induction of programmed cell death;pathogenesis;positive regulation of apoptosis;positive regulation of cell death;regulation of apoptosis;regulation of cell death;regulation of programmed cell death Huntington's disease 14 14 14 5.3 5.3 5.3 347.86 8.1543E-200 30212000 17459000 12753000 208 IPI:IPI00002335.1 Huntingtin;Huntington disease protein HTT;HD;IT15 P42858 ENST00000355072 K04533 1 0.9017 1.8002 0.93955 1.191 1.1544 1.2837 intracellular membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle;polysomal ribosome;ribonucleoprotein complex;ribosome binding;nucleic acid binding;protein binding;RNA binding 14 14 14 24.9 24.9 24.9 76.12 1.1714E-138 261840000 137610000 124230000 210 IPI:IPI00002349.2 Nuclear fragile X mental retardation-interacting protein 2;FMRP-interacting protein 2;82 kDa FMRP-interacting protein;Cell proliferation-inducing gene 1 protein NUFIP2;KIAA1321;PIG1 Q7Z417 ENST00000225388 1 0.85148 1.4129 0.63469 1.0548 0.99899 0.81015 MEF2_binding;TPR_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;enzyme inhibitor activity;enzyme regulator activity;phosphatase inhibitor activity;phosphatase regulator activity;phosphoprotein phosphatase inhibitor activity;protein phosphatase regulator activity cell communication;cell surface receptor linked signal transduction;cellular component organization;cellular process;chromatin modification;chromatin organization;organelle organization;regulation of biological process;signal transduction 4 4 4 2.3 2.3 2.3 246.35 9.0901E-05 22963000 12479000 10484000 211 IPI:IPI00002355.1 Calcineurin-binding protein cabin-1;Calcineurin inhibitor CABIN1;KIAA0330 Q9Y6J0 ENST00000263119;ENST00000398319 1 0.755 1.3468 0.72007 0.95915 0.89979 0.9616 ABC_membrane_2;ABC_tran integral to membrane;integral to organelle membrane;integral to peroxisomal membrane;intracellular part;intrinsic to membrane;intrinsic to organelle membrane;intrinsic to peroxisomal membrane;membrane part;microbody part;organelle part;peroxisomal part ATP binding;binding;catalytic activity;nucleoside binding;nucleotide binding;P-P-bond-hydrolysis-driven transmembrane transporter activity;primary active transmembrane transporter activity;protein binding;purine nucleoside binding;transporter activity cellular process;fatty acid transport;lipid transport;long-chain fatty acid transport;monocarboxylic acid transport;organelle organization;organic acid transport;peroxisomal long-chain fatty acid import;peroxisome organization;transport ABC transporters 18 18 18 29.1 29.1 29.1 75.475 4.5135E-203 731690000 398600000 333090000 212 IPI:IPI00002372.1;IPI:IPI00185503.4;IPI:IPI00884932.1;IPI:IPI00295818.4 ATP-binding cassette sub-family D member 3;70 kDa peroxisomal membrane protein;PMP70 ABCD3;PMP70;PXMP1 P28288-1;P28288;P28288-2 ENST00000370214;ENST00000394233 K05677 4 0.71055 NaN NaN 0.93257 NaN NaN 4 4 4 5.5 5.5 5.5 95.991 9.2886E-47 66734000 36007000 30727000 213 IPI:IPI00845386.1;IPI:IPI00465061.4;IPI:IPI00002396.4;IPI:IPI00845498.1;IPI:IPI00845283.1;IPI:IPI00845505.1;IPI:IPI00845250.1 Uncharacterized protein KIAA1310;Serum inhibited-related protein;Testis development protein PRTD KIAA1310;PRTD;SI1 Q9P2N6-1;Q9P2N6;Q9P2N6-3;Q9P2N6-2;Q9P2N6-4;Q9P2N6-5;Q9P2N6-6;Q9P2N6-8 ENST00000354204 7 0.3347 0.84223 NaN 0.44355 0.54505 NaN NTP_transf_2;OAS1_C cell fraction;cell part;insoluble fraction;membrane fraction;microsome;vesicular fraction ATP binding;binding;catalytic activity;nucleic acid binding;nucleoside binding;nucleotide binding;nucleotidyltransferase activity;purine nucleoside binding;RNA binding;transferase activity;transferase activity, transferring phosphorus-containing groups cellular metabolic process;cellular process;immune response;immune system process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;primary metabolic process;response to stimulus 2 2 2 2.9 2.9 2.9 121.16 1.2779E-10 3316500 1960000 1356500 214 IPI:IPI00002405.4 2'-5'-oligoadenylate synthetase 3;p100 OAS OAS3;P/OKcl.4 Q9Y6K5 ENST00000228928 K00992 1 0.67345 1.1147 0.65962 0.92374 0.75266 0.86475 TPR_1 binding 7 7 7 12.9 12.9 12.9 75.718 6.3344E-52 179580000 96182000 83398000 215 IPI:IPI00002408.4;IPI:IPI00448515.1 RNA polymerase II-associated protein 3 RPAP3 Q9H6T3-1;Q9H6T3;Q9H6T3-2 ENST00000005386;ENST00000380650 2 0.52181 0.95739 0.48604 0.66887 0.64104 0.66483 cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;molecular transducer activity;protein binding;signal transducer activity;transition metal ion binding;zinc ion binding activation of immune response;immune response-activating cell surface receptor signaling pathway;immune response-activating signal transduction;immune system process;positive regulation of immune system process;regulation of immune system process Acute myeloid leukemia;Adipocytokine signaling pathway;Apoptosis;B cell receptor signaling pathway;Chemokine signaling pathway;Chronic myeloid leukemia;Epithelial cell signaling in Helicobacter pylori infection;MAPK signaling pathway;Pancreatic cancer;Pathways in cancer;Primary immunodeficiency;Prostate cancer;Small cell lung cancer;T cell receptor signaling pathway;Toll-like receptor signaling pathway 9 9 9 27.7 27.7 27.7 48.197 7.8505E-87 123620000 66416000 57200000 216 IPI:IPI00002411.3 NF-kappa-B essential modulator;NF-kappa-B essential modifier;Inhibitor of nuclear factor kappa-B kinase subunit gamma;IkB kinase-associated protein 1;FIP-3 IKBKG;FIP3;NEMO Q9Y6K9 ENST00000369601;ENST00000369606;ENST00000369607;ENST00000369609 K07210 1 0.87355 1.543 0.89484 1.0913 1.0261 1.1994 Palm_thioest axon;cell fraction;clathrin-coated vesicle;coated vesicle;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;cytosol;extracellular region;Golgi apparatus;insoluble fraction;lysosome;lytic vacuole;membrane fraction;nucleus;synaptic vesicle;vacuole acyl-CoA thioesterase activity;catalytic activity;CoA hydrolase activity;hydrolase activity;hydrolase activity, acting on ester bonds;palmitoyl-(protein) hydrolase activity;palmitoyl-CoA hydrolase activity;thiolester hydrolase activity DNA catabolic process;DNA catabolic process, endonucleolytic;DNA metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein depalmitoylation;regulation of cell growth;system process Fatty acid elongation in mitochondria 7 7 7 37.6 37.6 37.6 34.193 0 646880000 333900000 312980000 217 IPI:IPI00002412.1 Palmitoyl-protein thioesterase 1;Palmitoyl-protein hydrolase 1 PPT1;PPT P50897 ENST00000372783 K01074 1 1.024 1.8911 1.017 1.3565 1.2704 1.3596 FYVE;PH cell part;cytoplasmic membrane-bounded vesicle;cytoplasmic part;cytoplasmic vesicle;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;membrane-bounded vesicle;organelle;transport vesicle;vesicle binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding 3 3 3 14.5 14.5 14.5 27.797 1.5133E-05 25750000 14053000 11696000 218 IPI:IPI00002424.1 Pleckstrin homology domain-containing family F member 2;PH and FYVE domain-containing protein 2;Zinc finger FYVE domain-containing protein 18 PLEKHF2;ZFYVE18 Q9H8W4 ENST00000315367 1 0.99007 1.7793 0.98334 1.2653 1.1933 1.2822 Annexin binding;calcium ion binding;calcium-dependent phospholipid binding;calcium-dependent protein binding;cation binding;ion binding;lipid binding;metal ion binding;phospholipid binding;protein binding 12 12 12 32.4 32.4 32.4 52.739 1.398E-118 905910000 453660000 452250000 219 IPI:IPI00002460.4;IPI:IPI00021771.1 Annexin A7;Annexin-7;Annexin VII;Synexin ANXA7;ANX7;SNX;OK/SW-cl.95 P20073-1;P20073;P20073-2 ENST00000372919;ENST00000372921;ENST00000394847 2 0.80955 1.7645 0.75958 1.1127 1.1066 0.95805 Peptidase_M13;Peptidase_M13_N cell fraction;clathrin-coated vesicle;coated vesicle;cytoplasmic membrane-bounded vesicle;external side of plasma membrane;Golgi apparatus;insoluble fraction;integral to membrane;intrinsic to membrane;membrane fraction;secretory granule binding;catalytic activity;endopeptidase activity;hormone binding;hydrolase activity;metalloendopeptidase activity;metallopeptidase activity;peptidase activity;peptide binding;peptide hormone binding;protein binding;zinc ion binding positive regulation of receptor recycling;regulation of receptor recycling;regulation of systemic arterial blood pressure by hormone;regulation of systemic arterial blood pressure mediated by a chemical signal;system process 5 5 5 9.7 9.7 9.7 87.163 5.3029E-75 34471000 17949000 16522000 220 IPI:IPI00002478.1;IPI:IPI00216762.1;IPI:IPI00216758.1;IPI:IPI00216760.1 Endothelin-converting enzyme 1 ECE1 P42892-1;P42892;P42892-4;P42892-2;P42892-3 ENST00000374893 K01415 4 0.51451 1.0249 0.47518 0.64531 0.68031 0.58569 MTHFR cell part;cytoplasmic part;cytosol;intracellular part binding;catalytic activity;methylenetetrahydrofolate reductase (NADPH) activity;oxidoreductase activity;oxidoreductase activity, acting on the CH-NH group of donors;protein binding cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;circulatory system process;methionine metabolic process;organic acid metabolic process;sulfur amino acid metabolic process;sulfur metabolic process;system process Methane metabolism;One carbon pool by folate 3 3 3 4.7 4.7 4.7 74.596 3.3329E-25 16612000 9271900 7340400 222 IPI:IPI00002487.4 Methylenetetrahydrofolate reductase MTHFR P42898 ENST00000376583;ENST00000376585;ENST00000376590;ENST00000376592 K00297 1 NaN 4.3904 NaN NaN 2.7887 NaN SH3_1;SH3_2;Sorb actin filament bundle;actomyosin;adherens junction;cell junction;cell-cell adherens junction;cell-cell junction;cell-substrate adherens junction;cell-substrate junction;cytosol;membrane-bounded organelle;nucleus;organelle;stress fiber;zonula adherens actin binding;binding;cytoskeletal protein binding;insulin receptor binding;molecular transducer activity;protein binding;protein binding, bridging;protein complex binding;receptor binding;SH3/SH2 adaptor activity;signal transducer activity actin filament organization;cell communication;cell-substrate junction assembly;cytoskeleton organization;organelle organization;regulation of carbohydrate metabolic process;regulation of glycogen biosynthetic process;signal transduction;transport Adherens junction;Insulin signaling pathway;PPAR signaling pathway 2 2 2 2.5 2.5 2.5 143.86 2.7123E-25 52053 48219 3834.6 223 IPI:IPI00306791.2;IPI:IPI00010555.3;IPI:IPI00454951.1;IPI:IPI00010554.2;IPI:IPI00334908.3;IPI:IPI00186452.4;IPI:IPI00064591.1;IPI:IPI00002491.3;IPI:IPI00454950.1;IPI:IPI00383430.1 Sorbin and SH3 domain-containing protein 1;Ponsin;c-Cbl-associated protein;SH3 domain protein 5;SH3P12 SORBS1;KIAA0894;KIAA1296;SH3D5 Q9BX66-1;Q9BX66;Q9BX66-2;Q9BX66-5;Q9BX66-3;Q9BX66-6;Q9BX66-10;Q9BX66-8;Q9BX66-9;Q9BX66-4;Q9BX66-7 ENST00000306402;ENST00000347291;ENST00000351042;ENST00000353505;ENST00000361941;ENST00000371227;ENST00000371246;ENST00000371247;ENST00000371249;ENST00000393945;ENST00000393949 K06086 10 0.78742 1.2725 0.7249 0.98819 0.88739 0.94243 Hexapep;NTP_transferase binding;catalytic activity;GTP binding;mannose-1-phosphate guanylyltransferase activity;mannose-phosphate guanylyltransferase activity;nucleotide binding;transferase activity;transferase activity, transferring phosphorus-containing groups biosynthetic process;metabolic process Fructose and mannose metabolism 8 8 8 27.4 27.4 27.4 42.621 1.543E-128 174130000 74538000 99590000 224 IPI:IPI00002496.2;IPI:IPI00030920.2 Mannose-1-phosphate guanyltransferase beta;GTP-mannose-1-phosphate guanylyltransferase beta;GDP-mannose pyrophosphorylase B GMPPB Q9Y5P6-2;Q9Y5P6;Q9Y5P6-1 ENST00000308375;ENST00000308388 K00971 2 0.75394 2.0302 NaN 1.0954 1.21 NaN Glycos_transf_2 cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part catalytic activity;dolichyl-phosphate beta-glucosyltransferase activity;oligosaccharyl transferase activity;transferase activity;transferase activity, transferring glycosyl groups;UDP-glycosyltransferase activity biopolymer metabolic process;carbohydrate metabolic process;cellular biopolymer metabolic process;cellular process;macromolecule metabolic process;metabolic process;protein amino acid glycosylation;protein metabolic process;protein modification process N-Glycan biosynthesis 5 5 5 17.6 17.6 17.6 36.946 1.7495E-11 9792600 5721800 4070700 225 IPI:IPI00002506.1 Dolichyl-phosphate beta-glucosyltransferase;Asparagine-linked glycosylation protein 5 ALG5;HSPC149 Q9Y673 ENST00000239891 K00729 1 0.87929 2.8186 NaN 1.161 1.7701 NaN TBC cell part;intracellular enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity;Rab GTPase activator activity;Ras GTPase activator activity;small GTPase regulator activity biological regulation;regulation of catalytic activity;regulation of GTPase activity;regulation of hydrolase activity;regulation of molecular function;regulation of Rab GTPase activity;regulation of Ras GTPase activity 2 2 2 5.9 5.9 5.9 59.08 0.0019429 2820000 1538400 1281500 226 IPI:IPI00002515.7 TBC1 domain family member 22B TBC1D22B;C6orf197 Q9NU19 ENST00000373491;ENST00000394449 1 0.70114 1.2648 0.66499 0.89517 0.82386 0.85448 SHMT cell part;cytoplasmic part;cytosol;intracellular part binding;catalytic activity;glycine hydroxymethyltransferase activity;lipid binding;methyltransferase activity;protein binding;steroid binding;transferase activity;transferase activity, transferring one-carbon groups;vitamin binding cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;protein complex assembly;purine base metabolic process Cyanoamino acid metabolism;Glycine, serine and threonine metabolism;Methane metabolism;One carbon pool by folate 14 13 13 39.3 36.4 36.4 53.082 0 357340000 200990000 156350000 227 IPI:IPI00002519.1;IPI:IPI00220668.1;IPI:IPI00220669.1 Serine hydroxymethyltransferase, cytosolic;Glycine hydroxymethyltransferase SHMT1 P34896-1;P34896;P34896-2;P34896-3 ENST00000316694;ENST00000352886;ENST00000354098 K00600 3 0.78497 1.4286 0.78421 1.0135 0.94557 1.0204 SHMT cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial nucleoid;mitochondrial part;nucleoid;organelle part binding;catalytic activity;glycine hydroxymethyltransferase activity;lipid binding;methyltransferase activity;protein binding;steroid binding;transferase activity;transferase activity, transferring one-carbon groups;vitamin binding cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;glycine metabolic process;L-serine metabolic process;nitrogen compound metabolic process;one-carbon metabolic process;organic acid metabolic process Cyanoamino acid metabolism;Glycine, serine and threonine metabolism;Methane metabolism;One carbon pool by folate 26 26 25 56.7 56.7 56.7 55.992 0 4881100000 2533900000 2347200000 228 IPI:IPI00002520.1 Serine hydroxymethyltransferase, mitochondrial;Glycine hydroxymethyltransferase SHMT2 P34897 ENST00000328923 K00600 1 0.66496 1.6801 0.78916 0.92705 1.0639 0.99377 ATP-synt_F6 intracellular part;macromolecular complex;membrane part;mitochondrial proton-transporting ATP synthase complex, coupling factor F(o);organelle part;protein complex;proton-transporting two-sector ATPase complex, proton-transporting domain cation transmembrane transporter activity;hydrogen ion transmembrane transporter activity;ion transmembrane transporter activity;monovalent inorganic cation transmembrane transporter activity;transmembrane transporter activity;transporter activity ATP biosynthetic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;transport Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 7 7 7 49.1 49.1 49.1 12.587 1.0046E-137 357420000 210740000 146680000 229 IPI:IPI00002521.1 ATP synthase-coupling factor 6, mitochondrial ATP5J;ATP5A;ATPM P18859 ENST00000284971;ENST00000400087;ENST00000400089;ENST00000400090;ENST00000400093;ENST00000400094;ENST00000400099 K02131 1 0.63938 1.9057 0.67373 0.84097 1.2169 0.92406 Cyt-b5 extracellular region part;extracellular space binding;cation binding;heme binding;ion binding;iron ion binding;metal ion binding;tetrapyrrole binding;transition metal ion binding 3 3 3 20.3 20.3 20.3 18.856 4.5393E-47 91408000 52483000 38925000 230 IPI:IPI00002525.3 Neudesin;Neuron-derived neurotrophic factor;Secreted protein of unknown function;Cell immortalization-related protein 2 NENF;CIR2;SPUF Q9UMX5 ENST00000366988 1 0.72181 1.9238 0.93901 0.89466 1.3759 1.1533 FKBP_C cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;intracellular organelle part;intracellular part;membrane;membrane part;organelle membrane;organelle part binding;catalytic activity;cis-trans isomerase activity;drug binding;FK506 binding;isomerase activity;macrolide binding;peptidyl-prolyl cis-trans isomerase activity;protein binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 2 2 2 18.3 18.3 18.3 15.649 6.0754E-25 272960000 137090000 135880000 231 IPI:IPI00002535.2 FK506-binding protein 2;Peptidyl-prolyl cis-trans isomerase;13 kDa FKBP;FKBP-13 FKBP2;FKBP13 P26885 ENST00000309366;ENST00000394540 K09569 1 0.35461 0.89283 0.34484 0.48102 0.60263 0.46796 Pkinase cell part;cytoplasm;cytoplasmic part;cytosol;intracellular part;membrane;plasma membrane 3-phosphoinositide-dependent protein kinase activity;ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding cell communication;cytoskeleton organization;negative regulation of protein kinase activity;organelle organization;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;signal transduction Endometrial cancer;Focal adhesion;Insulin signaling pathway;mTOR signaling pathway;Non-small cell lung cancer;PPAR signaling pathway;Prostate cancer 8 8 8 20.9 20.9 20.9 63.151 9.0854E-25 19213000 11780000 7433100 232 IPI:IPI00002538.1;IPI:IPI00216647.1;IPI:IPI00216646.4;IPI:IPI00749509.4 3-phosphoinositide-dependent protein kinase 1;Putative 3-phosphoinositide-dependent protein kinase 2 PDPK1;PDK1;PDPK2 O15530-1;O15530;O15530-3;O15530-2;Q6A1A2 ENST00000342085;ENST00000354836;ENST00000382326 K06276 4 1.0438 1.5955 1.0584 1.3088 1.1193 1.4162 APC2;Cullin cell part;cullin-RING ubiquitin ligase complex;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;protein complex;ubiquitin ligase complex acid-amino acid ligase activity;binding;catalytic activity;enzyme binding;ligase activity;ligase activity, forming carbon-nitrogen bonds;protein binding;small conjugating protein ligase activity;ubiquitin-protein ligase activity catabolic process;cyclin catabolic process;macromolecule catabolic process;metabolic process;mitosis;nuclear division;organelle organization;proteolysis;regulation of cyclin-dependent protein kinase activity;ubiquitin-dependent protein catabolic process Cell cycle;Cell cycle - yeast;Progesterone-mediated oocyte maturation;Ubiquitin mediated proteolysis 8 8 8 10.2 10.2 10.2 93.827 4.4291E-10 247900000 125740000 122160000 233 IPI:IPI00002549.1;IPI:IPI00375832.1 Anaphase-promoting complex subunit 2;Cyclosome subunit 2 ANAPC2;APC2;KIAA1406 Q9UJX6-1;Q9UJX6;Q9UJX6-2 ENST00000323927 K03349 2 0.65501 1.4874 0.56547 0.88863 0.96971 0.73678 anaphase-promoting complex;cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nuclear ubiquitin ligase complex;nucleoplasm;organelle part;protein complex;ubiquitin ligase complex acid-amino acid ligase activity;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;small conjugating protein ligase activity;ubiquitin-protein ligase activity catabolic process;cellular process;G2/M transition of mitotic cell cycle;macromolecule catabolic process;metabolic process;mitotic anaphase;proteasomal protein catabolic process;proteolysis;ubiquitin-dependent protein catabolic process Cell cycle;Cell cycle - yeast;Progesterone-mediated oocyte maturation;Ubiquitin mediated proteolysis 8 8 8 11.3 11.3 11.3 92.115 7.7323E-137 15117000 8702100 6414500 234 IPI:IPI00002551.4;IPI:IPI00419201.4 Anaphase-promoting complex subunit 4;Cyclosome subunit 4 ANAPC4;APC4 Q9UJX5-1;Q9UJX5;Q9UJX5-2 ENST00000315368 K03351 2 0.78578 1.3377 0.74499 0.99692 0.85784 1.0351 Adaptin_N;Gamma-COP cell part;COPI vesicle coat;cytoplasmic part;cytoplasmic vesicle part;Golgi apparatus part;intracellular organelle part;intracellular part;macromolecular complex;membrane coat;membrane part;organelle part;protein complex;vesicle coat binding;protein binding;structural molecule activity cellular process;establishment of protein localization;intracellular protein transport;intracellular transport;intra-Golgi vesicle-mediated transport;protein transport;retrograde vesicle-mediated transport, Golgi to ER;transport;vesicle-mediated transport 18 14 14 24.1 20.4 20.4 97.621 0 228650000 119900000 108760000 235 IPI:IPI00002557.1 Coatomer subunit gamma-2;Gamma-2-coat protein COPG2 Q9UBF2 1 0.71681 1.2997 0.75238 0.93291 0.87304 0.95748 BRCT;XRCC1_N cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;damaged DNA binding;DNA binding;nucleic acid binding;protein binding cellular process;DNA metabolic process;DNA repair;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to DNA damage stimulus;response to stress;single strand break repair 10 10 10 19 19 19 69.525 2.7999E-164 325130000 173330000 151800000 237 IPI:IPI00002564.3 DNA repair protein XRCC1;X-ray repair cross-complementing protein 1 XRCC1 P18887 ENST00000262887 1 0.82685 1.4063 0.80528 0.99515 0.98426 0.9786 cell part;cytoplasm;intracellular part cellular process;cellular response to stress;DNA metabolic process;DNA repair;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to DNA damage stimulus;response to stress 3 3 3 5 5 5 78.15 1.6722E-17 11056000 6192300 4863200 239 IPI:IPI00002614.3 UV radiation resistance-associated gene protein;p63 UVRAG Q9P2Y5 ENST00000356136 1 0.80015 1.5361 0.74227 1.0907 0.99685 1.0946 WD40 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;molecular transducer activity;protein binding;signal transducer activity;transcription cofactor activity;transcription corepressor activity;transcription factor binding;transcription regulator activity;transcription repressor activity cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 16 16 16 51.9 51.9 51.9 57.193 0 440190000 226890000 213310000 240 IPI:IPI00002624.1;IPI:IPI00382756.1 Pleiotropic regulator 1 PLRG1 O43660-1;O43660;O43660-2 ENST00000302078;ENST00000393905 2 0.64482 1.1897 NaN 0.82186 0.83402 NaN Ras binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleotide binding;pyrophosphatase activity biological regulation;cell communication;cellular process;intracellular signaling cascade;regulation of biological process;regulation of cellular process;signal transduction;small GTPase mediated signal transduction 3 3 3 15.3 15.3 15.3 26.186 3.8122E-07 8059400 2603400 5456000 241 IPI:IPI00221207.1;IPI:IPI00220774.1;IPI:IPI00002644.1;IPI:IPI00009415.1 Rab-like protein 2A;Rab-like protein 2B RABL2A;RABL2B Q9UBK7-2;Q9UBK7;Q9UNT1-2;Q9UNT1;Q9UBK7-1;Q9UNT1-1 ENST00000337788;ENST00000393166;ENST00000393167;ENST00000409875;ENST00000354869;ENST00000356653;ENST00000395593;ENST00000395598 K07931 4 NaN 1.4786 0.6658 NaN 1.0337 0.89747 Prefoldin centrosome;intracellular membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;microtubule organizing center;non-membrane-bounded organelle;nucleus;organelle;prefoldin complex beta-tubulin binding;binding;cytoskeletal protein binding;microtubule binding;protein binding;tubulin binding;unfolded protein binding cellular component organization;cellular process;metabolic process;microtubule-based movement;microtubule-based process;microtubule-based transport;organelle organization;protein folding;protein metabolic process;transport 2 2 2 15.3 15.3 15.3 18.246 3.9966E-52 83622000 52221000 31401000 242 IPI:IPI00002646.1 Protein UXT;Ubiquitously expressed transcript protein;Androgen receptor trapped clone 27 protein UXT;HSPC024 Q9UBK9 ENST00000333119;ENST00000335890 1 0.58843 3.2455 NaN 0.78172 2.1189 NaN AAA;MIT centrosome;endoplasmic reticulum;endosome;integral to membrane;intracellular organelle;intrinsic to membrane;membrane-bounded organelle;microtubule;microtubule organizing center;non-membrane-bounded organelle;nucleus;organelle;spindle ATP binding;binding;catalytic activity;cytoskeletal protein binding;microtubule binding;microtubule-severing ATPase activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity;tubulin binding cell cycle;cytoskeleton organization;ER to Golgi vesicle-mediated transport;microtubule bundle formation;microtubule cytoskeleton organization;microtubule-based process;organelle organization;protein complex assembly;transport 3 2 2 5 3.9 3.9 67.196 0.0044591 3717900 1672700 2045300 243 IPI:IPI00002707.1;IPI:IPI00219816.1;IPI:IPI00923553.1;IPI:IPI00923524.1 Spastin SPAST;ADPSP;FSP2;KIAA1083;SPG4 Q9UBP0-1;Q9UBP0;Q9UBP0-2;Q9UBP0-3;Q9UBP0-4 ENST00000315285 4 1.1159 1.9913 0.99803 1.5078 1.3434 1.2721 fn2;Sel1 cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part binding biological regulation;cell communication;cell surface receptor linked signal transduction;cellular process;Notch signaling pathway;regulation of biological process;regulation of cellular process;signal transduction 5 5 5 11.1 11.1 11.1 88.754 1.0815E-52 60815000 29865000 30950000 245 IPI:IPI00002790.3;IPI:IPI00555723.1 Protein sel-1 homolog 1;Suppressor of lin-12-like protein 1 SEL1L;TSA305;UNQ128/PRO1063 Q9UBV2-1;Q9UBV2 ENST00000336735 K07126 2 0.54482 1.0908 0.5376 0.72347 0.76338 0.66637 HR1;Pkinase;Pkinase_C cell part;membrane;plasma membrane ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein kinase C activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity activation of JUN kinase activity;activation of MAPK activity;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;regulation of protein amino acid phosphorylation 11 11 10 13.9 13.9 13.1 104.67 1.9392E-100 129490000 64297000 65191000 246 IPI:IPI00412672.1;IPI:IPI00002803.6;IPI:IPI00413780.3 Serine/threonine-protein kinase N1;Protein kinase C-like 1;Protein-kinase C-related kinase 1;Protein kinase C-like PKN;Serine-threonine protein kinase N;Protein kinase PKN-alpha PKN1;PKN;PRK1;PRKCL1 Q16512-2;Q16512;Q16512-1 ENST00000242783;ENST00000342216 K06071 3 NaN 2.4775 1.9684 NaN 1.7716 2.4951 LIM cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding anatomical structure morphogenesis;cell growth;cell proliferation;cellular process;developmental process;growth;organ morphogenesis 3 3 3 19.2 19.2 19.2 20.954 4.2853E-08 5036000 1373900 3662100 247 IPI:IPI00002824.7 Cysteine and glycine-rich protein 2;Smooth muscle cell LIM protein;LIM domain only protein 5 CSRP2;LMO5;SMLIM Q16527 ENST00000311083 K09377 1 0.45543 0.99064 0.41765 0.61007 0.59948 0.55743 condensed chromosome kinetochore;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;kinetochore;macromolecular complex;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 4 4 4 9.8 9.8 9.8 47.521 8.1488E-20 12619000 7252300 5367100 248 IPI:IPI00002828.3;IPI:IPI00783686.1 Centromere protein U;CENP-U(50);Interphase centromere complex protein 24;MLF1-interacting protein;KSHV latent nuclear antigen-interacting protein 1;Polo-box-interacting protein 1 MLF1IP;CENPU;ICEN24;KLIP1;PBIP1 Q71F23-1;Q71F23 ENST00000281453 K11513 2 0.79716 1.5252 0.71017 1.0648 0.99268 0.9639 B56 cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;organelle;protein complex;protein phosphatase type 2A complex;protein serine/threonine phosphatase complex binding;enzyme regulator activity;phosphatase regulator activity;protein binding;protein phosphatase regulator activity;protein phosphatase type 2A regulator activity biological regulation;cell communication;cellular process;regulation of biological process;regulation of cellular process;signal transduction Wnt signaling pathway 10 8 8 21.6 17.1 17.1 54.699 1.026E-168 151740000 79419000 72319000 250 IPI:IPI00002853.1;IPI:IPI00014980.1;IPI:IPI00219690.1 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform;PP2A, B subunit, B' epsilon isoform;PP2A, B subunit, B56 epsilon isoform;PP2A, B subunit, PR61 epsilon isoform;PP2A, B subunit, R5 epsilon isoform PPP2R5E Q16537 ENST00000337537 K11584 3 0.98686 1.6476 0.98842 1.2505 1.1338 1.2091 Pkinase cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part catalytic activity;MAP kinase activity;MAP kinase kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;receptor signaling protein serine/threonine kinase activity behavior;cell communication;cell motion;chemotaxis;intracellular signaling cascade;locomotory behavior;protein kinase cascade;Ras protein signal transduction;response to external stimulus;signal transduction;small GTPase mediated signal transduction Amyotrophic lateral sclerosis (ALS);Epithelial cell signaling in Helicobacter pylori infection;Fc epsilon RI signaling pathway;GnRH signaling pathway;Leukocyte transendothelial migration;MAPK signaling pathway;MAPK signaling pathway - yeast;Progesterone-mediated oocyte maturation;T cell receptor signaling pathway;Toll-like receptor signaling pathway;VEGF signaling pathway 17 17 3 55.3 55.3 6.9 41.293 0 477390000 253450000 223940000 251 IPI:IPI00002857.2;IPI:IPI00221142.3;IPI:IPI00221143.3;IPI:IPI00296283.3;IPI:IPI00005741.1;IPI:IPI00019473.2 Mitogen-activated protein kinase 14;Mitogen-activated protein kinase p38 alpha;Cytokine suppressive anti-inflammatory drug-binding protein;MAX-interacting protein 2;MAP kinase MXI2;SAPK2A MAPK14;CSBP;CSBP1;CSBP2;CSPB1;MXI2 Q16539-1;Q16539;Q16539-3;Q16539-4 ENST00000229794;ENST00000229795;ENST00000310795 K04441 6 0.65411 1.002 0.59922 0.80686 0.69778 0.76721 Cupin_4 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;nucleoplasm;organelle;organelle part biosynthetic process;chromatin organization;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;regulation of transcription, DNA-dependent;transcription 8 8 8 17.5 17.5 17.5 71.085 1.8056E-15 172760000 93294000 79469000 252 IPI:IPI00002879.5 Nucleolar protein 66 NO66;C14orf169 Q9H6W3 1 0.42788 0.72868 0.43885 0.54554 0.50391 0.56513 DNA_pol_B;DNA_pol_B_exo cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;catalytic activity;chromatin binding;DNA binding;DNA-directed DNA polymerase activity;exonuclease activity;nuclease activity;nucleic acid binding;nucleotide binding;protein binding;transferase activity;zinc ion binding DNA metabolic process;DNA replication;DNA synthesis during DNA repair;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleotide-excision repair, DNA gap filling;S phase of mitotic cell cycle DNA replication;Nucleotide excision repair 34 34 34 38.3 38.3 38.3 123.63 0 795570000 443230000 352340000 253 IPI:IPI00002894.2 DNA polymerase delta catalytic subunit;DNA polymerase subunit delta p125 POLD1;POLD P28340 ENST00000262266;ENST00000391817 K02327 1 NaN 0.71478 0.81244 NaN 0.43897 1.046 NUC156 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part 4 4 4 7.4 7.4 7.4 79.322 1.3844E-34 116950000 63874000 53078000 255 IPI:IPI00002902.5 Nucleolar protein 9 NOL9 Q5SY16 ENST00000377705 1 0.77012 1.509 0.79972 1.0928 0.96766 1.0509 LisH;WD40 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle chromatin organization;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;proteolysis;regulation of transcription, DNA-dependent;transcription Wnt signaling pathway 13 13 13 29.6 29.6 29.6 55.594 0 452710000 231590000 221120000 256 IPI:IPI00002922.5;IPI:IPI00640917.1;IPI:IPI00218132.2;IPI:IPI00020873.1 F-box-like/WD repeat-containing protein TBL1XR1;Transducin beta-like 1X-related protein 1;Nuclear receptor corepressor/HDAC3 complex subunit TBLR1;TBL1-related protein 1 TBL1XR1;IRA1;TBLR1 Q9BZK7 ENST00000352800 K04508 4 0.89939 1.5356 0.93193 1.1744 1.0047 1.2324 Mod_r cell part;cytoplasmic part;endosomal part;endosome membrane;intracellular organelle part;intracellular part;late endosome membrane;membrane;organelle membrane;organelle part establishment of localization;establishment of protein localization;protein transport;transport 4 4 4 20.7 20.7 20.7 31.307 6.6958E-107 63080000 33112000 29968000 257 IPI:IPI00002926.4 Vacuolar protein sorting-associated protein 37B;ESCRT-I complex subunit VPS37B VPS37B Q9H9H4 ENST00000267202 K12185 1 0.77255 1.3949 0.65727 1.0435 0.93916 0.83685 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;DNA binding;nucleic acid binding;protein binding;RNA binding;RNA polymerase II transcription factor activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent 4 4 4 13.6 13.6 13.6 31.079 2.3663E-22 44251000 25299000 18953000 258 IPI:IPI00002938.1 Activator of basal transcription 1;Basal transcriptional activator ABT1 Q9ULW3 ENST00000274849 1 1.042 2.0001 NaN 1.3151 1.3608 NaN TBC cell part;intracellular enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity;Rab GTPase activator activity;Ras GTPase activator activity;small GTPase regulator activity biological regulation;regulation of catalytic activity;regulation of GTPase activity;regulation of hydrolase activity;regulation of molecular function;regulation of Rab GTPase activity;regulation of Ras GTPase activity 3 3 3 5.4 5.4 5.4 72.653 1.6452E-74 3781000 2179900 1601100 259 IPI:IPI00002957.1 TBC1 domain family member 17 TBC1D17 Q9HA65 ENST00000221543 1 1.1047 1.9501 1.099 1.4468 1.294 1.4523 HSP70 cell part;cytoplasm;intracellular part adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding anatomical structure formation;cellular component assembly;cellular component organization;cellular process;protein complex assembly;response to biotic stimulus;response to organic substance;response to stress;response to unfolded protein Antigen processing and presentation 48 48 44 59.4 59.4 56.4 94.33 0 8292600000 4117700000 4174900000 260 IPI:IPI00002966.2 Heat shock 70 kDa protein 4;Heat shock 70-related protein APG-2;HSP70RY HSPA4;APG2 P34932 ENST00000304858 K09489 1 0.97505 1.7714 1.0114 1.319 1.1428 1.2822 ThiS cell part;cytoplasmic part;cytosol;intracellular part;macromolecular complex;molybdopterin synthase complex;protein complex biosynthetic process;cellular aromatic compound metabolic process;coenzyme biosynthetic process;coenzyme metabolic process;metabolic process;Mo-molybdopterin cofactor biosynthetic process;nitrogen compound metabolic process;sulfur metabolic process 3 3 3 37.5 37.5 37.5 9.7552 9.9043E-23 87223000 44643000 42580000 261 IPI:IPI00002968.1 Molybdenum cofactor synthesis protein 2A;Molybdenum cofactor synthesis protein 2 small subunit;Molybdopterin-synthase small subunit;MOCO1-A MOCS2;MOCO1 O96033 1 NaN 1.1307 NaN NaN 0.79534 NaN TFIID-31kDa histone acetyltransferase complex;intracellular part;macromolecular complex;nuclear part;organelle part;PCAF complex;protein complex;STAGA complex;transcription factor complex;transcription factor TFIID complex;transcription factor TFTC complex binding;DNA binding;nucleic acid binding;protein binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding;transcription regulator activity chromatin organization;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of cell growth;regulation of transcription, DNA-dependent;RNA elongation;transcription initiation Basal transcription factors 3 3 3 11.4 11.4 11.4 28.974 1.135E-12 1764600 925430 839200 262 IPI:IPI00002993.1;IPI:IPI00642105.1 Transcription initiation factor TFIID subunit 9;Transcription initiation factor TFIID 31 kDa subunit;TAFII-32;RNA polymerase II TBP-associated factor subunit G;STAF31/32;Transcription initiation factor TFIID subunit 9B;Transcription initiation factor TFIID subunit 9-like;Transcription-associated factor TAFII31L;Neuronal cell death-related protein 7 TAF9;TAF2G;TAFII31;TAF9B;TAF9L Q16594;Q9HBM6 ENST00000217893;ENST00000328663;ENST00000341864;ENST00000400856 K03133 2 0.60965 1.6261 0.67494 0.77657 1.0997 0.85686 Mito_carr cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part amine transmembrane transporter activity;amino acid transmembrane transporter activity;binding;L-glutamate transmembrane transporter activity;organic acid transmembrane transporter activity;protein binding;transporter activity acidic amino acid transport;amine transport;amino acid transport;carboxylic acid transport;cellular process;establishment of localization;L-glutamate transport;organic acid transport;transmembrane transport;transport 10 10 10 37.5 37.5 37.5 34.47 1.294E-74 121300000 66214000 55090000 263 IPI:IPI00003004.1;IPI:IPI00027826.6 Mitochondrial glutamate carrier 1;Glutamate/H(+) symporter 1;Solute carrier family 25 member 22 SLC25A22;GC1 Q9H936 ENST00000320230 2 0.81388 1.5324 0.66738 1.034 1.0678 0.90817 Cajal body;cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;nuclear body;nuclear part;nucleoplasm part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;protein binding cellular component biogenesis;cellular process;ribonucleoprotein complex biogenesis;spliceosomal snRNP biogenesis 2 2 2 18.3 18.3 18.3 14.536 2.789E-08 13176000 7338600 5837500 265 IPI:IPI00003027.1 Gem-associated protein 7;SIP3 GEMIN7 Q9H840 ENST00000270257;ENST00000391951 1 0.67993 1.7061 0.76495 0.93454 1.0621 1.0221 Isochorismatase cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;nucleus;organelle binding;catalytic activity;protein binding macromolecule metabolic process;metabolic process;posttranscriptional regulation of gene expression;protein destabilization;protein metabolic process;regulation of gene expression;regulation of metabolic process;regulation of protein stability 4 4 4 33.5 33.5 33.5 24.097 3.6964E-93 32053000 18080000 13973000 266 IPI:IPI00003031.3;IPI:IPI00551022.3 Isochorismatase domain-containing protein 2, mitochondrial ISOC2 Q96AB3-2;Q96AB3;Q96AB3-1 ENST00000085068 2 0.71771 1.3682 0.8555 0.90394 1.0006 1.2557 CBFD_NFYB_HMF cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;protein binding;transcription cofactor activity;transcription corepressor activity;transcription factor activity;transcription factor binding;transcription regulator activity;transcription repressor activity negative regulation of transcription from RNA polymerase II promoter;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 6 6 6 16 16 16 23.205 2.2551E-35 128210000 60837000 67370000 269 IPI:IPI00477494.2;IPI:IPI00003084.1 Dr1-associated corepressor;Dr1-associated protein 1;Negative co-factor 2-alpha DRAP1 Q14919-2;Q14919;Q14919-1 ENST00000312515;ENST00000376991 2 NaN 1.486 NaN NaN 1.06 NaN Pkinase cell part;cytoplasmic part;cytosol;intracellular part catalytic activity;JUN kinase activity;MAP kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;receptor signaling protein serine/threonine kinase activity activation of pro-apoptotic gene products;cell motion;JUN phosphorylation;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;response to radiation;response to UV Adipocytokine signaling pathway;Colorectal cancer;Epithelial cell signaling in Helicobacter pylori infection;ErbB signaling pathway;Fc epsilon RI signaling pathway;Focal adhesion;GnRH signaling pathway;Insulin signaling pathway;MAPK signaling pathway;Pancreatic cancer;Pathways in cancer;Progesterone-mediated oocyte maturation;Toll-like receptor signaling pathway;Type II diabetes mellitus;Wnt signaling pathway 6 3 2 15.2 8.4 4.9 48.295 4.7379E-58 4133100 1687000 2446100 270 IPI:IPI00024672.1;IPI:IPI00220306.1;IPI:IPI00003145.1;IPI:IPI00220305.1 Mitogen-activated protein kinase 8;Stress-activated protein kinase JNK1;c-Jun N-terminal kinase 1;JNK-46 MAPK8;JNK1;PRKM8 P45983-1;P45983;P45983-4;P45983-2;P45983-3 ENST00000360332;ENST00000374176;ENST00000374179;ENST00000374182;ENST00000374189 K04440 4 0.84373 1.3261 0.7358 1.0282 0.94435 0.94757 Pribosyltran;RelB binding;catalytic activity;diphosphotransferase activity;enzyme inhibitor activity;magnesium ion binding;ribose phosphate diphosphokinase activity;transferase activity;transferase activity, transferring phosphorus-containing groups biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside metabolic process;nucleoside phosphate metabolic process;nucleotide metabolic process 9 8 8 37.1 33.3 33.3 40.925 5.0094E-208 260620000 137430000 123190000 271 IPI:IPI00003168.1 Phosphoribosyl pyrophosphate synthetase-associated protein 2;41 kDa phosphoribosypyrophosphate synthetase-associated protein PRPSAP2 O60256 ENST00000268835;ENST00000395656 1 0.8234 1.6502 0.84694 1.0924 1.0666 1.093 Proteasome cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;proteasome core complex;protein complex catalytic activity;endopeptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides;threonine-type endopeptidase activity;threonine-type peptidase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Proteasome 9 9 9 27.8 27.8 27.8 29.965 5.6137E-294 730010000 379050000 350960000 272 IPI:IPI00003217.3 Proteasome subunit beta type-7;Proteasome subunit Z;Macropain chain Z;Multicatalytic endopeptidase complex chain Z PSMB7 Q99436 ENST00000259457 K02739 1 0.7492 1.8089 0.80628 1.0101 1.1302 1.0405 Actin cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding 14 2 2 24.2 7.4 7.4 42.003 3.8796E-292 15680000000 8348100000 7332200000 273 IPI:IPI00003269.1 Beta-actin-like protein 2;Kappa-actin ACTBL2 Q562R1 ENST00000306758 1 8.3632 1.0756 0.48182 11.751 0.68865 0.64628 C1_1;DAGK_acc;DAGK_cat cell part;integral to membrane;intrinsic to membrane;membrane part ATP binding;binding;catalytic activity;diacylglycerol kinase activity;kinase activity;lipid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;transferase activity;zinc ion binding cell communication;cell surface receptor linked signal transduction;G-protein coupled receptor protein signaling pathway;lipid metabolic process;phospholipid metabolic process;signal transduction Glycerolipid metabolism;Glycerophospholipid metabolism;Phosphatidylinositol signaling system 3 3 3 10.4 10.4 10.4 63.926 5.8946E-43 6808200 3431700 3376500 274 IPI:IPI00003293.1 Diacylglycerol kinase epsilon;Diglyceride kinase epsilon DGKE;DAGK5 P52429 ENST00000284061 K00901 1 0.6656 1.2086 0.66232 0.84098 0.8071 0.84387 RNA_pol_Rpb8 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;nucleoplasm;organelle;organelle part binding;catalytic activity;DNA-directed RNA polymerase activity;ion binding;nucleotidyltransferase activity;protein binding;RNA polymerase activity;transferase activity;transferase activity, transferring phosphorus-containing groups;zinc ion binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile Huntington's disease;RNA polymerase 6 6 6 41.3 41.3 41.3 17.143 4.6041E-164 555840000 296970000 258870000 275 IPI:IPI00003309.4 DNA-directed RNA polymerases I, II, and III subunit RPABC3;DNA-directed RNA polymerase II subunit H;DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide;RPB17;hRPB8 POLR2H P52434 ENST00000296223 K03016 1 0.62833 1.1986 0.53194 0.83855 0.81234 0.70622 RNA_pol_N cell part;DNA-directed RNA polymerase complex;DNA-directed RNA polymerase II, core complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;RNA polymerase complex binding;catalytic activity;DNA binding;DNA-directed RNA polymerase activity;nucleic acid binding;nucleotidyltransferase activity;RNA polymerase activity;transferase activity;transferase activity, transferring phosphorus-containing groups;zinc ion binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile;transcription Huntington's disease;RNA polymerase 4 4 4 40.3 40.3 40.3 7.645 1.3038E-17 114960000 65947000 49017000 276 IPI:IPI00003311.1 DNA-directed RNA polymerases I, II, and III subunit RPABC5;DNA-directed RNA polymerase III subunit L;RPB10;DNA-directed RNA polymerase II 7.6 kDa polypeptide;RPB7.6 POLR2L P62875 ENST00000322028 K03007 1 NaN 0.56864 0.36135 NaN 0.41043 0.45155 zf-HIT binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding 3 3 3 10.2 10.2 10.2 42.883 4.9614E-08 17672000 9144900 8527600 277 IPI:IPI00003318.1 Zinc finger HIT domain-containing protein 2 ZNHIT2;C11orf5 Q9UHR6 ENST00000310597 1 0.55859 0.97783 0.51484 0.74421 0.62417 0.66193 Arf centrosome;cytoplasmic part;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;microtubule organizing center;non-membrane-bounded organelle;organelle;organelle part binding;enzyme inhibitor activity;enzyme regulator activity;GTP binding;GTPase inhibitor activity;GTPase regulator activity;guanyl nucleotide binding;nucleotide binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding anatomical structure formation;cell communication;cell cycle;cellular component organization;cellular process;intracellular signaling cascade;protein complex assembly;signal transduction;small GTPase mediated signal transduction;tubulin complex assembly 5 5 5 30.4 30.4 30.4 20.878 7.7917E-46 129320000 74225000 55094000 279 IPI:IPI00003326.4 ADP-ribosylation factor-like protein 2 ARL2 P36404 ENST00000246747 K07943 1 0.83578 1.5517 0.84565 1.1041 1.0456 1.0863 Arf Golgi membrane;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;membrane;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle;organelle membrane;organelle part;spindle binding;cation binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;ion binding;magnesium ion binding;metal ion binding;nucleotide binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding biological regulation;cell communication;cell cycle;cell division;cellular process;intracellular signaling cascade;regulation of biological process;regulation of cellular process;signal transduction;small GTPase mediated signal transduction 6 6 6 41.8 41.8 41.8 20.455 4.3236E-56 308970000 162970000 146010000 280 IPI:IPI00003327.1 ADP-ribosylation factor-like protein 3 ARL3;ARFL3 P36405 ENST00000260746 K07944 1 0.86478 1.4915 0.9041 1.1018 0.99921 1.1107 WD40 catalytic activity;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;pyrophosphatase activity;signal transducer activity cell communication;cell surface receptor linked signal transduction;G-protein coupled receptor protein signaling pathway;intracellular signaling cascade;response to endogenous stimulus;response to hormone stimulus;signal transduction Chemokine signaling pathway 12 7 7 48.5 30.3 30.3 37.331 7.1462E-303 804410000 398820000 405590000 281 IPI:IPI00003348.3;IPI:IPI00012451.3 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Transducin beta chain 2;G protein subunit beta-2 GNB2 P62879 ENST00000303210;ENST00000393924;ENST00000393926 K04537 2 1.3559 2.6781 1.3793 1.7659 1.7345 1.8016 HSP70 cell surface;cytoplasmic membrane-bounded vesicle;endoplasmic reticulum lumen;ER-Golgi intermediate compartment;integral to endoplasmic reticulum membrane;integral to membrane;intrinsic to endoplasmic reticulum membrane;intrinsic to membrane;nucleus ATP binding;binding;calcium ion binding;cysteine-type endopeptidase inhibitor activity;endopeptidase inhibitor activity;enzyme inhibitor activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding anti-apoptosis;cell communication;cellular process;cellular response to starvation;negative regulation of peptidase activity;regulation of cell death;response to external stimulus;response to extracellular stimulus;response to stress 42 40 40 53 53 53 72.421 0 14233000000 6297700000 7935400000 282 IPI:IPI00003362.2 78 kDa glucose-regulated protein;GRP 78;Heat shock 70 kDa protein 5;Immunoglobulin heavy chain-binding protein;Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78 HSPA5;GRP78 P11021 ENST00000324460 K09490 1 NaN 1.7043 0.76234 NaN 1.0809 0.92721 LIM binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding cell communication;cellular process;multicellular organismal development;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of transcription, DNA-dependent;signal transduction 3 3 3 6.7 6.7 6.7 72.189 9.1901E-71 4668000 2527400 2140600 283 IPI:IPI00003369.1 LIM domain-containing protein 1 LIMD1 Q9UGP4 ENST00000273317 1 0.74802 1.4259 0.73002 0.9644 0.94635 0.95229 RRM_1;zf-CCHC cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding;transition metal ion binding;zinc ion binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 8 8 7 30.7 30.7 30.7 27.366 2.1923E-93 2568900000 1359200000 1209700000 284 IPI:IPI00003377.1;IPI:IPI00744364.4;IPI:IPI00939530.1 Splicing factor, arginine/serine-rich 7;Splicing factor 9G8 SFRS7 Q16629-1;Q16629;Q16629-3;Q16629-2 ENST00000313117;ENST00000378857;ENST00000378869 3 0.45957 1.1502 0.54621 0.67718 0.69979 0.75235 zf-C3HC4 cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle acid-amino acid ligase activity;binding;catalytic activity;cation binding;ion binding;ligase activity;ligase activity, forming carbon-nitrogen bonds;NEDD8 ligase activity;protein binding;small conjugating protein ligase activity;zinc ion binding DNA metabolic process;DNA repair;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein modification process;proteolysis;response to DNA damage stimulus;response to stress Cell cycle;Cell cycle - yeast;Nucleotide excision repair;Pathways in cancer;Renal cell carcinoma;TGF-beta signaling pathway;Ubiquitin mediated proteolysis;Wnt signaling pathway 3 3 3 32.4 32.4 32.4 12.274 7.052E-58 398670000 226710000 171970000 285 IPI:IPI00003386.3 RING-box protein 1;Regulator of cullins 1;RING finger protein 75;Protein ZYP RBX1;RNF75;ROC1 P62877 ENST00000216225 K03868 1 0.78985 1.6599 0.85701 1.0156 1.1587 1.1024 SMN Cajal body;cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;nuclear body;nuclear part;nucleoplasm part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;protein binding;RNA binding anatomical structure formation;cell death;cellular component assembly;cellular component organization;cellular process;death;ribonucleoprotein complex assembly;ribonucleoprotein complex biogenesis;spliceosomal snRNP biogenesis;spliceosome assembly 3 3 3 17.3 17.3 17.3 31.848 1.6296E-57 86403000 47009000 39395000 286 IPI:IPI00003394.1;IPI:IPI00009597.1;IPI:IPI00219360.1;IPI:IPI00009598.1 Survival motor neuron protein;Component of gems 1;Gemin-1 SMN1;SMN;SMNT;SMN2;SMNC Q16637-1;Q16637;Q16637-3;Q16637-2;Q16637-4 ENST00000305043;ENST00000351205;ENST00000380707;ENST00000380741;ENST00000380742;ENST00000380743 4 0.73945 1.4934 0.75146 1.0222 0.99301 1.0037 Cofilin_ADF actomyosin;cell part;cell projection;cytoplasm;cytoskeletal part;dendrite;intracellular organelle part;intracellular part;neuron projection;organelle part actin binding;binding;cytoskeletal protein binding;profilin binding;protein binding actin filament organization;actin filament-based process;cellular component organization;cellular process;cytoskeleton organization;organelle organization;regulation of cell communication;regulation of neuron projection development 20 20 20 33.3 33.3 33.3 71.428 0 2167700000 1152000000 1015800000 287 IPI:IPI00003406.4;IPI:IPI00295624.5 Drebrin;Developmentally-regulated brain protein DBN1;D0S117E Q16643-1;Q16643;Q16643-2 ENST00000292385;ENST00000309007;ENST00000393563;ENST00000393565 2 0.69057 1.8844 0.80263 1.0283 1.0782 1.1488 3 3 3 12.6 12.6 12.6 20.332 2.1632E-133 99651000 54586000 45065000 288 IPI:IPI00003419.1 Small acidic protein SMAP;C11orf58 O00193 ENST00000228136 1 1.0402 1.9106 1.0537 1.405 1.2329 1.3929 CH;EB1 cell part;cytoplasm;cytoskeletal part;intracellular organelle part;intracellular part;microtubule;organelle part binding;cytoskeletal protein binding;microtubule binding;protein binding;tubulin binding cell communication;cell cycle phase;cell cycle process;cell proliferation;cellular component organization;cellular process;mitosis;nuclear division;organelle fission;organelle organization;regulation of biological process;signal transduction 14 12 12 33 31.2 31.2 37.031 6.1228E-247 847760000 399180000 448580000 289 IPI:IPI00003420.1;IPI:IPI00552652.1;IPI:IPI00017597.3;IPI:IPI00553216.1 Microtubule-associated protein RP/EB family member 2;APC-binding protein EB2;End-binding protein 2 MAPRE2;RP1 Q15555-1;Q15555 ENST00000300249 K10436 4 0.92419 1.4199 0.94127 1.159 1.0177 1.1999 Nrf1_activ_bdg;Nrf1_DNA-bind cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding generation of precursor metabolites and energy;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription Huntington's disease 2 2 2 3.4 3.4 3.4 53.54 0.0019736 19205000 9471600 9733700 290 IPI:IPI00003428.1;IPI:IPI00219917.1 Nuclear respiratory factor 1;Alpha palindromic-binding protein NRF1 Q16656-1;Q16656;Q16656-2 ENST00000223190;ENST00000353868;ENST00000393230;ENST00000393231;ENST00000393232 K11831 2 0.80802 1.6658 0.84257 1.1296 1.0359 1.1027 DnaJ binding;heat shock protein binding;protein binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 10 10 10 36 36 36 29.841 1.0796E-66 742060000 387160000 354910000 291 IPI:IPI00003438.2 DnaJ homolog subfamily C member 8;Splicing protein spf31 DNAJC8;SPF31;HSPC315;HSPC331 O75937 ENST00000263697 K09528 1 0.60653 1.1445 0.59555 0.82017 0.74624 0.80169 HIN;PAAD_DAPIN cell part;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;nucleoplasm;organelle;organelle part binding;DNA binding;double-stranded DNA binding;nucleic acid binding;protein binding;structure-specific DNA binding;transcription regulator activity;transcription repressor activity induction of apoptosis;leukocyte differentiation;myeloid leukocyte differentiation;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 36 36 36 43.9 43.9 43.9 88.255 0 3565900000 2068000000 1497900000 292 IPI:IPI00003443.3;IPI:IPI00217475.2;IPI:IPI00217474.6;IPI:IPI00384836.2;IPI:IPI00398847.1;IPI:IPI00397542.1;IPI:IPI00412281.1;IPI:IPI00397544.1;IPI:IPI00103253.1;IPI:IPI00893471.1;IPI:IPI00175151.7;IPI:IPI00654641.3;IPI:IPI00026533.7 Gamma-interferon-inducible protein Ifi-16;Interferon-inducible myeloid differentiation transcriptional activator;IFI 16 IFI16;IFNGIP1 Q16666-1;Q16666;Q16666-3;Q16666-2;Q16666-5 ENST00000295809;ENST00000340979;ENST00000368131;ENST00000392247 13 0.77796 1.5785 0.72527 1.0263 1.0203 0.96903 Pkinase cell part;cytoplasmic part;cytoskeleton;cytosol;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleoplasm;organelle;organelle part adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding behavior;cell communication;cell cycle;cell-cell signaling;chemotaxis;induction of apoptosis;intracellular signaling cascade;Ras protein signal transduction;signal transduction;small GTPase mediated signal transduction;synaptic transmission Acute myeloid leukemia;Adherens junction;Alzheimer's disease;Axon guidance;B cell receptor signaling pathway;Bladder cancer;Chemokine signaling pathway;Chronic myeloid leukemia;Colorectal cancer;Dorso-ventral axis formation;Endometrial cancer;ErbB signaling pathway;Fc epsilon RI signaling pathway;Focal adhesion;Gap junction;Glioma;GnRH signaling pathway;Insulin signaling pathway;Long-term depression;Long-term potentiation;MAPK signaling pathway;MAPK signaling pathway - fly;Melanogenesis;Melanoma;mTOR signaling pathway;Natural killer cell mediated cytotoxicity;Non-small cell lung cancer;Pancreatic cancer;Pathways in cancer;Progesterone-mediated oocyte maturation;Prostate cancer;Regulation of actin cytoskeleton;Renal cell carcinoma;T cell receptor signaling pathway;TGF-beta signaling pathway;Thyroid cancer;Toll-like receptor signaling pathway;Type II diabetes mellitus;Vascular smooth muscle contraction;VEGF signaling pathway 17 11 11 46.1 34.2 34.2 41.389 4.245E-262 1338900000 689980000 648900000 293 IPI:IPI00003479.3;IPI:IPI00021396.1;IPI:IPI00337568.3;IPI:IPI00015902.3;IPI:IPI00003431.1;IPI:IPI00010156.2;IPI:IPI00936281.2 Mitogen-activated protein kinase 1;Extracellular signal-regulated kinase 2;Mitogen-activated protein kinase 2;p42-MAPK;ERT1 MAPK1;ERK2;PRKM1;PRKM2 P28482 ENST00000215832;ENST00000398822 K04371 7 0.90682 1.7758 0.88193 1.2072 1.1472 1.0813 adh_short cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle 2,4-dienoyl-CoA reductase (NADPH) activity;binding;catalytic activity;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on the CH-CH group of donors anatomical structure formation;catabolic process;cellular process;fatty acid beta-oxidation;fatty acid catabolic process;fatty acid metabolic process;lipid metabolic process;metabolic process;organic acid metabolic process;protein complex assembly 9 9 9 33.4 33.4 33.4 36.067 2.3173E-70 245420000 132040000 113380000 294 IPI:IPI00003482.1 2,4-dienoyl-CoA reductase, mitochondrial;2,4-dienoyl-CoA reductase [NADPH] DECR1;DECR Q16698 ENST00000220764 K00219 1 0.6202 1.1381 0.59736 0.79137 0.79632 0.78579 AAA cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;hydrolase activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity;transcription cofactor activity;transcription factor binding biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent 18 18 18 46.8 46.8 46.8 48.55 7.1681E-184 1079300000 603920000 475370000 296 IPI:IPI00003505.3;IPI:IPI00847729.2 Thyroid receptor-interacting protein 13;Thyroid hormone receptor interactor 13;Human papillomavirus type 16 E1 protein-binding protein TRIP13 Q15645-1;Q15645 ENST00000166345;ENST00000354240 2 0.74402 1.9893 1.0709 1.0795 1.1931 1.3507 cell part;cytoplasmic part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;nucleus;organelle binding;protein binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding;transcription regulator activity biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent 14 14 14 8.9 8.9 8.9 227.64 1.6773E-27 169150000 87733000 81420000 297 IPI:IPI00003515.1 Thyroid receptor-interacting protein 11;Golgi-associated microtubule-binding protein 210;GMAP-210;Trip230;Clonal evolution-related gene on chromosome 14 TRIP11;CEV14 Q15643 ENST00000267622 1 0.65544 1.2767 0.65378 0.86685 0.85678 0.85382 EFG_C;EFG_IV;GTP_EFTU;GTP_EFTU_D2 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 40 39 38 47.9 46.9 46.3 109.43 0 2835500000 1542500000 1292900000 298 IPI:IPI00003519.1 116 kDa U5 small nuclear ribonucleoprotein component;U5 snRNP-specific protein, 116 kDa;Elongation factor Tu GTP-binding domain-containing protein 2 EFTUD2;KIAA0031;SNRP116 Q15029 ENST00000262414 1 0.68991 1.4295 0.76337 0.97973 0.88674 1.0008 EBP50_C-term;PDZ actin cytoskeleton;cell part;cell projection;cytoskeleton;endomembrane system;filopodium;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;microvillus;non-membrane-bounded organelle;organelle;ruffle adrenergic receptor binding;beta-2 adrenergic receptor binding;binding;G-protein-coupled receptor binding;PDZ domain binding;protein binding;protein domain specific binding;receptor binding anatomical structure formation;cell communication;cell surface receptor linked signal transduction;cellular component assembly;cellular component organization;cellular process;protein complex assembly;signal transduction;Wnt receptor signaling pathway 18 18 17 48.3 48.3 48.3 38.868 0 2210200000 905650000 1304600000 299 IPI:IPI00003527.5 Na(+)/H(+) exchange regulatory cofactor NHE-RF1;Ezrin-radixin-moesin-binding phosphoprotein 50;Regulatory cofactor of Na(+)/H(+) exchanger;Sodium-hydrogen exchanger regulatory factor 1;Solute carrier family 9 isoform A3 regulatory factor 1 SLC9A3R1;NHERF;NHERF1 O14745 ENST00000262613 1 0.90897 2.2656 0.97382 1.2724 1.3594 1.3496 Ank cell part;cytoplasmic part;cytoskeleton;cytosol;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;organelle;proteasome regulatory particle;protein complex binding;protein binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process 6 6 6 41.2 41.2 41.2 24.428 1.6213E-36 309900000 165630000 144270000 300 IPI:IPI00003565.1 26S proteasome non-ATPase regulatory subunit 10;26S proteasome regulatory subunit p28;Gankyrin PSMD10 O75832 ENST00000217958 K06694 1 0.78068 1.6146 0.76817 1.0419 1.0692 1.0209 GST_C cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;negative regulation of cell proliferation;positive regulation of signal transduction;regulation of cell communication;regulation of signal transduction;translation 11 11 11 64.9 64.9 64.9 19.81 1.6961E-72 836450000 406540000 429910000 301 IPI:IPI00003588.1 Eukaryotic translation elongation factor 1 epsilon-1;Multisynthetase complex auxiliary component p18;Elongation factor p18 EEF1E1;AIMP3;P18 O43324 ENST00000379715 1 0.47452 1.5831 0.73001 0.64515 0.96838 0.98414 IBR;RWD;zf-C3HC4 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;ligase activity;protein binding;receptor binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding;zinc ion binding nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein modification process;proteolysis;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 2 2 2 4.9 4.9 4.9 53.837 7.6032E-07 8193600 4872700 3320900 302 IPI:IPI00003606.3 E3 ubiquitin-protein ligase RNF14;RING finger protein 14;Androgen receptor-associated protein 54;Triad2 protein;HFB30 RNF14;ARA54;HRIHFB2038 Q9UBS8 ENST00000347642;ENST00000356143;ENST00000394519;ENST00000394520 K11971 1 0.75256 1.479 0.69981 0.95952 1.0149 0.84824 Actin chromatin remodeling complex;H4/H2A histone acetyltransferase complex;histone acetyltransferase complex;macromolecular complex;membrane;NuA4 histone acetyltransferase complex;organelle part;plasma membrane;protein complex;SWI/SNF complex adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;chromatin binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding chromatin organization;chromatin remodeling;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein amino acid acetylation;protein modification process;regulation of transcription, DNA-dependent;transcription 13 13 13 36.4 36.4 36.4 47.46 1.97E-205 416450000 224820000 191630000 303 IPI:IPI00003627.1;IPI:IPI00216622.1;IPI:IPI00007776.1 Actin-like protein 6A;53 kDa BRG1-associated factor A;Actin-related protein Baf53a;ArpNbeta;INO80 complex subunit K ACTL6A;BAF53;BAF53A;INO80K O96019-1;O96019;O96019-2 ENST00000259034;ENST00000392662 K11340 3 NaN 1.1595 NaN NaN 0.81926 NaN Rad1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 3'-5' exonuclease activity;binding;catalytic activity;damaged DNA binding;deoxyribonuclease activity;DNA binding;exodeoxyribonuclease activity;exodeoxyribonuclease III activity;exonuclease activity;nuclease activity;nucleic acid binding;protein binding cell cycle checkpoint;DNA damage checkpoint;DNA metabolic process;DNA repair;DNA replication;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to DNA damage stimulus;response to stress Cell cycle - yeast 3 3 3 9.9 9.9 9.9 31.827 4.0875E-10 8224300 3944500 4279700 304 IPI:IPI00003647.1;IPI:IPI00107483.1 Cell cycle checkpoint protein RAD1;DNA repair exonuclease rad1 homolog;Rad1-like DNA damage checkpoint protein RAD1;REC1 O60671-1;O60671;O60671-2 ENST00000231383;ENST00000341754;ENST00000382038 K02830 2 0.81671 1.2723 0.77442 1.0279 0.87248 0.99627 RRM_1;zf-CCHC cell part;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;cation binding;ion binding;metal ion binding;nucleic acid binding;nucleotide binding;RNA binding;transition metal ion binding;zinc ion binding cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 15 15 3 46.7 46.7 15.7 40.313 1.9778E-245 1075700000 550500000 525170000 305 IPI:IPI00003704.4;IPI:IPI00556034.1;IPI:IPI00940890.1 RNA-binding protein 4;RNA-binding motif protein 4;RNA-binding motif protein 4a;Lark homolog RBM4;RBM4A Q9BWF3-1;Q9BWF3;Q9BWF3-2;Q9BWF3-3 ENST00000310092;ENST00000310137;ENST00000398692;ENST00000408993;ENST00000409406 3 0.63275 0.96211 0.43695 0.7821 0.65855 0.5865 DEAD;Helicase_C ATP binding;ATP-dependent helicase activity;binding;catalytic activity;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity;RNA binding 11 11 11 27.5 27.5 27.5 54.226 2.8638E-111 68803000 37931000 30872000 306 IPI:IPI00003739.5 Probable ATP-dependent RNA helicase DDX49;DEAD box protein 49 DDX49 Q9Y6V7 ENST00000247003 1 0.43536 0.86801 NaN 0.57069 0.59782 NaN Calpain_III;MIT;Peptidase_C2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle calcium-dependent cysteine-type endopeptidase activity;catalytic activity;cysteine-type endopeptidase activity;cysteine-type peptidase activity;endopeptidase activity;hydrolase activity;peptidase activity biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis 7 7 7 9.1 9.1 9.1 92.651 5.9679E-50 10893000 5740500 5152200 307 IPI:IPI00003765.1 Calpain-7;PalB homolog CAPN7;PALBH Q9Y6W3 ENST00000253693 K08576 1 0.87563 1.5842 0.81926 1.1136 1.0913 1.0067 Lactamase_B cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;mitochondrial matrix;mitochondrial part;nucleus;organelle;organelle part binding;catalytic activity;cation binding;hydrolase activity;ion binding;metal ion binding;transition metal ion binding;zinc ion binding 8 8 8 48 48 48 27.873 7.097E-67 185180000 99065000 86119000 308 IPI:IPI00003766.4 Protein ETHE1, mitochondrial;Ethylmalonic encephalopathy protein 1;Hepatoma subtracted clone one protein ETHE1;HSCO O95571 ENST00000292147 1 0.61039 1.0969 0.61636 0.79058 0.74155 0.78959 BRCT;Pescadillo_N cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleolar part;nucleoplasm;organelle part;PeBoW complex;preribosome;preribosome, large subunit precursor;protein complex;ribonucleoprotein complex binding;protein binding maturation of 5.8S rRNA;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);maturation of LSU-rRNA;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 17 17 17 25.3 25.3 25.3 68.002 4.5916E-145 1136300000 613130000 523190000 309 IPI:IPI00003768.1;IPI:IPI00554461.1 Pescadillo homolog PES1 O00541-1;O00541;O00541-2 ENST00000335214 2 0.59702 1.2186 0.56363 0.80005 0.78687 0.77392 Pkinase extracellular region ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;protein tyrosine kinase activity;purine nucleoside binding;transferase activity cell communication;intracellular signaling cascade;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;signal transduction;small GTPase mediated signal transduction Acute myeloid leukemia;B cell receptor signaling pathway;Bladder cancer;Chronic myeloid leukemia;Endometrial cancer;ErbB signaling pathway;Fc epsilon RI signaling pathway;Gap junction;Glioma;GnRH signaling pathway;Insulin signaling pathway;Long-term depression;Long-term potentiation;MAPK signaling pathway;Melanogenesis;Melanoma;Natural killer cell mediated cytotoxicity;Non-small cell lung cancer;Pathways in cancer;Prostate cancer;Regulation of actin cytoskeleton;Renal cell carcinoma;T cell receptor signaling pathway;Thyroid cancer;Toll-like receptor signaling pathway;Vascular smooth muscle contraction;VEGF signaling pathway 26 26 17 66.2 66.2 48 44.424 0 1067600000 601900000 465720000 310 IPI:IPI00003783.1 Dual specificity mitogen-activated protein kinase kinase 2;ERK activator kinase 2;MAPK/ERK kinase 2 MAP2K2;MEK2;MKK2;PRKMK2 P36507 ENST00000262948 K04369 1 1.0281 1.5843 NaN 1.3343 1.0799 NaN Alpha-mann_mid;Glyco_hydro_38;Glyco_hydro_38C cell part;cytoplasmic part;Golgi apparatus part;Golgi membrane;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part alpha-mannosidase activity;binding;catalytic activity;hydrolase activity, hydrolyzing O-glycosyl compounds;mannosidase activity;mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity;mannosyl-oligosaccharide mannosidase activity;zinc ion binding alcohol metabolic process;carbohydrate metabolic process;hexose metabolic process;mannose metabolic process;metabolic process;monosaccharide metabolic process;primary metabolic process N-Glycan biosynthesis 7 7 7 8.2 8.2 8.2 131.14 5.8338E-50 8247600 4353900 3893700 312 IPI:IPI00003802.2 Alpha-mannosidase 2;Alpha-mannosidase II;Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase;Golgi alpha-mannosidase II;Mannosidase alpha class 2A member 1 MAN2A1;MANA2 Q16706 ENST00000261483 K01231 1 0.78896 1.3494 0.55866 1.1269 0.86095 0.73681 Pkinase catalytic activity;MAP kinase kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;protein serine/threonine/tyrosine kinase activity;purine nucleoside binding cell cycle arrest;DNA damage induced protein phosphorylation;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;response to DNA damage stimulus;response to stress Amyotrophic lateral sclerosis (ALS);Fc epsilon RI signaling pathway;GnRH signaling pathway;MAPK signaling pathway;Toll-like receptor signaling pathway 14 14 14 49.1 49.1 49.1 37.492 8.7215E-120 69617000 38956000 30661000 314 IPI:IPI00003814.1;IPI:IPI00219569.1 Dual specificity mitogen-activated protein kinase kinase 6;MAPK/ERK kinase 6;SAPKK3 MAP2K6;MEK6;MKK6;PRKMK6 P52564-1;P52564;P52564-2 ENST00000359094 K04433 2 0.76564 1.567 0.69416 0.98482 0.96111 0.9317 Rho_GDI cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle binding;enzyme activator activity;enzyme regulator activity;GDP-dissociation inhibitor activity;GTPase activator activity;GTPase regulator activity;protein binding;Rho GDP-dissociation inhibitor activity;small GTPase regulator activity anti-apoptosis;cell communication;cell motion;intracellular signaling cascade;negative regulation of cell adhesion;Ras protein signal transduction;Rho protein signal transduction;signal transduction;small GTPase mediated signal transduction 13 13 13 81.9 81.9 81.9 23.207 9.8778E-246 2292700000 1257700000 1035000000 315 IPI:IPI00003815.3 Rho GDP-dissociation inhibitor 1;Rho-GDI alpha ARHGDIA;GDIA1 P52565 ENST00000269321 1 0.83706 1.7452 0.86002 1.1736 1.1157 1.1836 Rho_GDI cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;cytoskeleton;intracellular membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;membrane-bounded vesicle;non-membrane-bounded organelle;organelle;vesicle enzyme activator activity;enzyme regulator activity;GDP-dissociation inhibitor activity;GTPase activator activity;GTPase regulator activity;Rho GDP-dissociation inhibitor activity;small GTPase regulator activity cell communication;cell motion;cytoskeleton organization;immune response;immune system process;intracellular signaling cascade;negative regulation of cell adhesion;organelle organization;signal transduction;small GTPase mediated signal transduction 23 23 23 89.1 89.1 89.1 22.988 0 9047700000 4897200000 4150500000 316 IPI:IPI00003817.3 Rho GDP-dissociation inhibitor 2;Rho-GDI beta;Ly-GDI ARHGDIB;GDIA2;GDID4;RAP1GN1 P52566 ENST00000228945 1 0.7767 1.2026 0.64796 1.0597 0.79665 0.887 Pro_isomerase Golgi lumen;intracellular membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;membrane-enclosed lumen;nucleus;organelle;organelle lumen;organelle part;protein complex;ubiquitin ligase complex acid-amino acid ligase activity;catalytic activity;cis-trans isomerase activity;isomerase activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;peptidyl-prolyl cis-trans isomerase activity;ubiquitin-protein ligase activity cellular biopolymer metabolic process;cellular process;metabolic process;protein folding;protein metabolic process;protein modification by small protein conjugation;protein modification process;protein polyubiquitination;protein ubiquitination Ubiquitin mediated proteolysis 6 6 6 12.7 12.7 12.7 59.457 2.0231E-10 20772000 11171000 9601600 317 IPI:IPI00217324.1;IPI:IPI00003824.1 Peptidyl-prolyl cis-trans isomerase-like 2;Cyclophilin-60;Cyclophilin-like protein Cyp-60 PPIL2 Q13356-2;Q13356;Q13356-1 ENST00000335025;ENST00000398831;ENST00000406385 K10598 2 0.82871 1.6199 0.97618 1.0522 1.1568 1.2495 PS_Dcarbxylase cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle carbon-carbon lyase activity;carboxy-lyase activity;catalytic activity;lyase activity;phosphatidylserine decarboxylase activity biosynthetic process;cellular metabolic process;cellular process;lipid biosynthetic process;lipid metabolic process;metabolic process;organophosphate metabolic process;phospholipid biosynthetic process;phospholipid metabolic process Glycerophospholipid metabolism;Glycine, serine and threonine metabolism 6 6 6 19.2 19.2 19.2 43.046 2.174E-20 256150000 130730000 125420000 318 IPI:IPI00003827.1;IPI:IPI00937891.1 Phosphatidylserine decarboxylase proenzyme;Phosphatidylserine decarboxylase alpha chain;Phosphatidylserine decarboxylase beta chain PISD Q9UG56-2;Q9UG56;Q9UG56-3 ENST00000266095;ENST00000336566;ENST00000397503;ENST00000397508 K01613 2 0.58267 1.1174 0.56129 0.77167 0.71288 0.76161 Mito_carr cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part binding establishment of localization;transport 11 11 11 44.6 44.6 44.6 33.331 3.9048E-231 495250000 276030000 219230000 319 IPI:IPI00003833.3 Mitochondrial carrier homolog 2;Met-induced mitochondrial protein MTCH2;MIMP;HSPC032 Q9Y6C9 ENST00000302503 1 3.0244 6.426 2.5526 4.4897 4.1916 3.4215 DnaJ;DnaJ_C binding;heat shock protein binding;protein binding;unfolded protein binding cellular process;metabolic process;protein folding;response to abiotic stimulus;response to biotic stimulus;response to heat;response to organic substance;response to stress;response to temperature stimulus;response to unfolded protein 4 3 3 14.2 10.7 10.7 37.806 5.9219E-38 23587000 9639000 13948000 321 IPI:IPI00003848.1 DnaJ homolog subfamily B member 4;Heat shock 40 kDa protein 1 homolog;HSP40 homolog;Human liver DnaJ-like protein DNAJB4;DNAJW;HLJ1 Q9UDY4 ENST00000370763 K09510 1 1.0164 1.7453 0.93914 1.2935 1.1943 1.2562 vATP-synt_E cell part;macromolecular complex;membrane part;protein complex;proton-transporting two-sector ATPase complex, catalytic domain binding;catalytic activity;cation transmembrane transporter activity;hydrogen ion transmembrane transporter activity;ion transmembrane transporter activity;monovalent inorganic cation transmembrane transporter activity;protein binding;transporter activity ATP biosynthetic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;transport 7 7 7 28.8 28.8 28.8 26.145 6.8492E-56 452810000 226010000 226800000 322 IPI:IPI00003856.1;IPI:IPI00059139.1 V-type proton ATPase subunit E 1;Vacuolar proton pump subunit E 1;V-ATPase 31 kDa subunit ATP6V1E1;ATP6E;ATP6E2 P36543 ENST00000253413 2 1.8334 3.3804 1.7832 2.4312 2.2175 2.3522 HSP70 cell surface;cytoplasmic membrane-bounded vesicle;cytoplasmic part;cytoplasmic vesicle;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;melanosome;membrane-bounded organelle;membrane-bounded vesicle;organelle;vesicle ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity cellular biopolymer metabolic process;cellular process;metabolic process;protein folding;protein metabolic process;response to biotic stimulus;response to chemical stimulus;response to organic substance;response to stress;response to unfolded protein Antigen processing and presentation;MAPK signaling pathway 48 48 34 68.6 68.6 57.1 70.897 0 95317000000 40653000000 54664000000 323 IPI:IPI00003865.1;IPI:IPI00939595.1 Heat shock cognate 71 kDa protein;Heat shock 70 kDa protein 8 HSPA8;HSC70;HSP73;HSPA10 P11142-1;P11142;P11142-2 ENST00000227378;ENST00000392773 K03283 2 0.86924 1.6728 0.91589 1.0823 1.0465 1.1478 CLP_protease cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle ATP binding;binding;catalytic activity;endopeptidase activity;hydrolase activity;nucleoside binding;nucleotide binding;peptidase activity;protein binding;purine nucleoside binding;serine-type endopeptidase activity;serine-type peptidase activity biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis 8 8 8 40.4 40.4 40.4 30.18 1.9665E-166 278590000 135850000 142740000 324 IPI:IPI00003870.1 Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial;Endopeptidase Clp CLPP Q16740 ENST00000245816 K01358 1 0.76814 1.362 0.75856 0.98454 0.89334 0.95812 RRM_1;zf-RNPHF cell part;heterogeneous nuclear ribonucleoprotein complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 16 14 14 54 47.5 47.5 45.671 0 4736200000 2458700000 2277500000 325 IPI:IPI00003881.5 Heterogeneous nuclear ribonucleoprotein F;Nucleolin-like protein mcs94-1;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed HNRNPF;HNRPF P52597 ENST00000337970;ENST00000356053;ENST00000357065 1 0.58428 1.0722 0.58827 0.81867 0.68242 0.78471 GN3L_Grn1;MMR_HSR1 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;protein binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding biological regulation;regulation of biological process;regulation of cell proliferation;regulation of cellular process 18 18 18 36.6 36.6 36.6 61.992 1.8417E-202 1033400000 564200000 469210000 326 IPI:IPI00306380.11;IPI:IPI00003886.3 Guanine nucleotide-binding protein-like 3;Nucleolar GTP-binding protein 3;Nucleostemin;E2-induced gene 3 protein;Novel nucleolar protein 47 GNL3;E2IG3;NS Q9BVP2-1;Q9BVP2;Q9BVP2-2 ENST00000354540;ENST00000394799 2 0.63232 1.3701 0.69107 0.88798 0.87457 0.97948 Ribosomal_L4 cell part;cytoplasmic part;cytosolic large ribosomal subunit;cytosolic part;intracellular organelle part;intracellular part;large ribosomal subunit;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit binding;nucleic acid binding;protein binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 28 28 28 48.7 48.7 48.7 47.697 0 10114000000 5433400000 4681000000 327 IPI:IPI00003918.6 60S ribosomal protein L4;L1 RPL4;RPL1 P36578 ENST00000307961 K02930 1 0.79725 1.3996 0.78809 1.0553 0.9451 1.0268 4_1_CTD;FA;FERM_C;FERM_M;FERM_N;SAB cytoskeleton;extrinsic to membrane;intracellular organelle;macromolecular complex;membrane;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle;plasma membrane;spectrin;spectrin-associated cytoskeleton actin binding;binding;cytoskeletal protein binding;lipid binding;phosphatidylinositol binding;phosphoinositide binding;phospholipid binding;protein binding;spectrin binding;structural constituent of cytoskeleton;structural molecule activity actin cytoskeleton organization;actin filament-based process;blood circulation;cellular component organization;cellular process;circulatory system process;cortical cytoskeleton organization;cytoskeleton organization;organelle organization;system process Tight junction 14 14 13 18.3 18.3 17.1 97.016 4.7153E-147 340860000 190140000 150720000 328 IPI:IPI00003921.2;IPI:IPI00218697.2;IPI:IPI00218698.2;IPI:IPI00218699.1;IPI:IPI00218700.2;IPI:IPI00218701.3;IPI:IPI00553103.4 Protein 4.1;Band 4.1;P4.1;EPB4.1;4.1R EPB41;E41P P11171-1;P11171;P11171-2;P11171-3;P11171-4;P11171-5;P11171-6;P11171-7 ENST00000343067;ENST00000347529;ENST00000349460;ENST00000356093;ENST00000358989;ENST00000373798;ENST00000398865 K06107 7 0.52632 1.275 0.54737 0.69856 0.83419 0.73535 OMPdecase;Pribosyltran cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle catalytic activity;lyase activity;orotate phosphoribosyltransferase activity;orotidine-5'-phosphate decarboxylase activity;transferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring pentosyl groups 'de novo' pyrimidine base biosynthetic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;pyrimidine base metabolic process;pyrimidine nucleoside metabolic process;pyrimidine nucleotide metabolic process Drug metabolism - other enzymes;Pyrimidine metabolism 21 21 21 52.7 52.7 52.7 52.221 0 410200000 230410000 179800000 329 IPI:IPI00003923.1;IPI:IPI00398067.3 Uridine 5'-monophosphate synthase;Orotate phosphoribosyltransferase;Orotidine 5'-phosphate decarboxylase;OMPdecase UMPS;OK/SW-cl.21 P11172-1;P11172;P11172-2 ENST00000232607 K00762;K01591 2 0.7845 1.5272 0.7742 1.0575 0.98473 1.0366 Transket_pyr;Transketolase_C cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor;pyruvate dehydrogenase (acetyl-transferring) activity;pyruvate dehydrogenase activity acetyl-CoA metabolic process;alcohol metabolic process;carbohydrate metabolic process;generation of precursor metabolites and energy;glucose catabolic process;glucose metabolic process;glycolysis;monosaccharide metabolic process;tricarboxylic acid cycle Butanoate metabolism;Citrate cycle (TCA cycle);Glycolysis / Gluconeogenesis;Pyruvate metabolism;Valine, leucine and isoleucine biosynthesis 11 11 11 39.3 39.3 39.3 39.233 0 840610000 448890000 391720000 330 IPI:IPI00003925.6;IPI:IPI00549885.4 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB;PHE1B P11177-1;P11177;P11177-2 ENST00000302746;ENST00000383714 K00162 2 1.055 2.0651 1.0492 1.4406 1.2817 1.434 Pro_isomerase;TPR_1 cell part;cytoplasm;intracellular part binding;catalytic activity;cis-trans isomerase activity;cyclosporin A binding;drug binding;heat shock protein binding;isomerase activity;peptide binding;peptidyl-prolyl cis-trans isomerase activity;protein binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process Calcium signaling pathway;Huntington's disease;Parkinson's disease 21 21 21 57 57 57 40.763 7.6961E-231 1287000000 641910000 645100000 331 IPI:IPI00003927.5 40 kDa peptidyl-prolyl cis-trans isomerase;Cyclophilin-40;Cyclophilin-related protein PPID;CYP40;CYPD Q08752 ENST00000307720 K05864 1 0.82244 1.5835 0.8543 1.0697 1.057 1.133 Lactamase_B binding;catalytic activity;cation binding;hydrolase activity;hydrolase activity, acting on ester bonds;hydroxyacylglutathione hydrolase activity;ion binding;metal ion binding;thiolester hydrolase activity;transition metal ion binding;zinc ion binding Pyruvate metabolism 7 7 7 34.1 34.1 34.1 33.805 1.4302E-189 313720000 171950000 141770000 332 IPI:IPI00003933.2;IPI:IPI00745553.1 Hydroxyacylglutathione hydrolase;Glyoxalase II HAGH;GLO2;HAGH1 Q16775-1;Q16775;Q16775-2 ENST00000262303;ENST00000397353;ENST00000397356 K01069 2 0.67592 1.4296 0.71853 0.90052 0.95129 0.94201 Histone cell part;chromosomal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;macromolecular complex;membrane-bounded organelle;nucleosome;nucleus;organelle;organelle part;protein-DNA complex binding;DNA binding;nucleic acid binding;protein binding anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;chromatin organization;nucleosome assembly;organelle organization Systemic lupus erythematosus 10 3 1 55.6 9.5 9.5 13.906 7.6999E-188 11761000000 6258100000 5503100000 333 IPI:IPI00152785.3;IPI:IPI00220403.3;IPI:IPI00515061.3;IPI:IPI00003935.6;IPI:IPI00454695.4;IPI:IPI00746251.3;IPI:IPI00465363.3 Histone H2B type 1-O;H2B.n;H2B/n;H2B.2;Histone H2B type 1-B;H2B.f;H2B/f;H2B.1;Histone H2B type 1-J;H2B.r;H2B/r;Histone H2B type 2-E;H2B.q;H2B/q;H2B-GL105 HIST1H2BO;H2BFH;H2BFN;HIST1H2BB;H2BFF;HIST1H2BJ;H2BFR;HIST2H2BE;H2BFQ P23527;P33778;P06899;Q16778 ENST00000303806;ENST00000357905;ENST00000244601;ENST00000406237;ENST00000327774;ENST00000369155 K11252 7 0.97947 2.1419 0.93461 1.3247 1.3942 1.217 2-oxoacid_dh;Biotin_lipoyl;E3_binding cytoplasmic part;intracellular part;macromolecular complex;mitochondrial alpha-ketoglutarate dehydrogenase complex;mitochondrial nucleoid;mitochondrial part;mitochondrial tricarboxylic acid cycle enzyme complex;nucleoid;organelle part;protein complex acyltransferase activity;binding;carboxylic acid binding;catalytic activity;lipoic acid binding;protein binding;transferase activity;transferase activity, transferring acyl groups;transferase activity, transferring acyl groups other than amino-acyl groups acyl-CoA metabolic process;biosynthetic process;coenzyme metabolic process;fatty acid biosynthetic process;fatty acid metabolic process;lipid biosynthetic process;lipid metabolic process;metabolic process;organic acid metabolic process Valine, leucine and isoleucine degradation 7 7 7 17.6 17.6 17.6 53.486 5.0083E-55 68860000 38037000 30824000 334 IPI:IPI00003944.1 Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial;Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase;Dihydrolipoamide branched chain transacylase;BCKAD E2 subunit DBT;BCATE2 P11182 ENST00000370132 K09699 1 0.74284 1.5815 0.78265 0.97525 1.0068 1.0486 UQ_con cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;protein complex;UBC13-MMS2 complex;ubiquitin conjugating enzyme complex acid-amino acid ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;ubiquitin-protein ligase activity activation of immune response;DNA catabolic process, exonucleolytic;DNA double-strand break processing;double-strand break repair via homologous recombination;immune system process;recombinational repair Ubiquitin mediated proteolysis 10 10 10 65.8 65.8 65.8 17.138 7.7873E-160 2175200000 1159000000 1016200000 335 IPI:IPI00003949.1;IPI:IPI00376844.1 Ubiquitin-conjugating enzyme E2 N;Ubiquitin-protein ligase N;Ubiquitin carrier protein N;Ubc13;Bendless-like ubiquitin-conjugating enzyme UBE2N;BLU P61088 ENST00000318066 K10580 2 0.87444 1.5748 0.91685 1.1397 1.0681 1.1947 UCH cell part;cytoplasm;intracellular part binding;catalytic activity;cysteine-type endopeptidase activity;cysteine-type peptidase activity;endopeptidase activity;hydrolase activity;hydrolase activity, acting on ester bonds;peptidase activity;protein binding;ubiquitin thiolesterase activity cell communication;cell surface receptor linked signal transduction;enzyme linked receptor protein signaling pathway;protein modification process;proteolysis;signal transduction;ubiquitin-dependent protein catabolic process 21 21 21 9.2 9.2 9.2 292.28 7.2501E-115 190520000 96651000 93865000 336 IPI:IPI00221012.7;IPI:IPI00003964.4;IPI:IPI00874074.2;IPI:IPI00744575.3 Probable ubiquitin carboxyl-terminal hydrolase FAF-X;Ubiquitin thioesterase FAF-X;Ubiquitin-specific-processing protease FAF-X;Deubiquitinating enzyme FAF-X;Ubiquitin-specific protease 9, X chromosome;Fat facets protein-related, X-linked;Fat facets in mammals;Probable ubiquitin carboxyl-terminal hydrolase FAF-Y;Ubiquitin thioesterase FAF-Y;Ubiquitin-specific-processing protease FAF-Y;Deubiquitinating enzyme FAF-Y;Fat facets protein-related, Y-linked;Ubiquitin-specific protease 9, Y chromosome USP9X;DFFRX;FAM;USP9;USP9Y;DFFRY;USP10 Q93008-2;Q93008;Q93008-1;O00507-1;O00507;O00507-2 ENST00000324545;ENST00000378308;ENST00000338981 K11840 4 0.77311 1.4656 0.75236 1.0448 0.9407 0.98253 MATH;UCH cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;cysteine-type endopeptidase activity;cysteine-type peptidase activity;endopeptidase activity;peptidase activity;protein binding;protein C-terminus binding;ubiquitin thiolesterase activity;ubiquitin-specific protease activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;protein deubiquitination;protein metabolic process;protein modification process;proteolysis;ubiquitin-dependent protein catabolic process 40 40 40 39.4 39.4 39.4 128.3 0 1885100000 1002200000 882890000 337 IPI:IPI00003965.5 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin thioesterase 7;Ubiquitin-specific-processing protease 7;Deubiquitinating enzyme 7;Herpesvirus-associated ubiquitin-specific protease USP7;HAUSP Q93009 ENST00000344836;ENST00000381886 K11838 1 0.90025 1.7026 1.0353 1.1526 1.0867 1.4054 Epimerase cytoplasmic part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;mitochondrial matrix;mitochondrial part;mitochondrial respiratory chain complex I;NADH dehydrogenase complex;organelle part;protein complex binding;catalytic activity;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;protein binding cation transport;cellular process;generation of precursor metabolites and energy;ion transport;metabolic process;mitochondrial electron transport, NADH to ubiquinone;monovalent inorganic cation transport;sodium ion transport;transport Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 15 15 15 43.8 43.8 43.8 42.509 8.4897E-113 389790000 237560000 152220000 338 IPI:IPI00003968.1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial;NADH-ubiquinone oxidoreductase 39 kDa subunit;Complex I-39kD NDUFA9;NDUFS2L Q16795 ENST00000266544 K03953 1 0.68972 1.2578 0.69788 0.90167 0.8814 0.90213 AAA;BCS1_N cytoplasmic part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;macromolecular complex;membrane part;mitochondrial part;mitochondrial respiratory chain complex III;organelle part;protein complex ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity anatomical structure formation;cellular component organization;cellular process;NADH dehydrogenase complex assembly;protein complex assembly;respiratory chain complex IV assembly;sensory perception;sensory perception of sound;system process 8 8 8 24.1 24.1 24.1 47.534 1.2908E-118 60611000 31989000 28621000 340 IPI:IPI00003985.1 Mitochondrial chaperone BCS1;BCS1-like protein;H-BCS1 BCS1L;BCS1 Q9Y276 ENST00000359273;ENST00000392109;ENST00000392110;ENST00000392111 K08900 1 0.72601 1.5954 0.65278 0.97414 1.0392 0.87984 Abhydrolase_1 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle catalytic activity;hydrolase activity cellular amino acid and derivative metabolic process;cellular metabolic process;cellular process;metabolic process;primary metabolic process;response to chemical stimulus;response to stimulus;response to toxin 5 5 5 15.1 15.1 15.1 32.542 1.2319E-36 39007000 22230000 16777000 341 IPI:IPI00384428.3;IPI:IPI00003990.1 Valacyclovir hydrolase;Biphenyl hydrolase-like protein;Biphenyl hydrolase-related protein;Breast epithelial mucin-associated antigen BPHL;MCNAA Q86WA6-1;Q86WA6;Q86WA6-2 ENST00000380375;ENST00000380379 K01175 2 0.38411 0.86871 0.57268 0.50199 0.61041 0.75008 Med12 centrosome;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;mediator complex;microtubule organizing center;non-membrane-bounded organelle;nucleolus;organelle;organelle part;protein complex binding;protein binding;receptor activity;receptor binding;RNA polymerase II transcription factor activity;signal transducer activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding cell communication;intracellular signaling cascade;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;signal transduction;transcription initiation;transcription initiation from RNA polymerase II promoter 7 7 7 4 4 4 247.33 8.3848E-16 45920000 24687000 21232000 342 IPI:IPI00004068.2;IPI:IPI00913988.1;IPI:IPI00640149.1 Mediator of RNA polymerase II transcription subunit 12;Mediator complex subunit 12;Thyroid hormone receptor-associated protein complex 230 kDa component;Activator-recruited cofactor 240 kDa component;CAG repeat protein 45;OPA-containing protein;Trinucleotide repeat-containing gene 11 protein MED12;ARC240;CAGH45;HOPA;KIAA0192;TNRC11;TRAP230 Q93074-3;Q93074;Q93074-2;Q93074-1 ENST00000374080 3 0.86892 1.6992 0.85306 1.1767 1.167 1.0548 Cation_ATPase_C;Cation_ATPase_N;E1-E2_ATPase;Hydrolase cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;nuclear membrane;nuclear part;organelle membrane;organelle part;sarcoplasmic reticulum membrane ATP binding;binding;calcium ion binding;calcium-transporting ATPase activity;catalytic activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;transporter activity ATP biosynthetic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;transport Alzheimer's disease;Calcium signaling pathway 17 12 12 21.7 15 15 114.87 0 331950000 180480000 151480000 343 IPI:IPI00218442.4;IPI:IPI00303760.2;IPI:IPI00004092.2;IPI:IPI00218440.1;IPI:IPI00748794.1;IPI:IPI00478023.1 Sarcoplasmic/endoplasmic reticulum calcium ATPase 3;Calcium pump 3;SR Ca(2+)-ATPase 3 ATP2A3 Q93084-6;Q93084;Q93084-5;Q93084-1;Q93084-3;Q93084-2;Q93084-4 ENST00000309890;ENST00000352011;ENST00000359983;ENST00000397035;ENST00000397041 K05853 6 0.65585 1.3398 0.64155 0.91665 0.84578 0.90458 FHA;K167R cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cell cycle;cell proliferation;cellular process 60 60 60 24.2 24.2 24.2 358.69 0 1072700000 590040000 482680000 344 IPI:IPI00004233.2;IPI:IPI00413173.3 Antigen KI-67 MKI67 P46013-1;P46013;P46013-2 ENST00000368653;ENST00000368654 2 0.50269 1.2425 NaN 0.68568 0.79066 NaN PHK_AB cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;organelle;plasma membrane binding;calmodulin binding;calmodulin-dependent protein kinase activity;catalytic activity;kinase activity;phosphorylase kinase activity;protein binding;protein kinase activity;protein serine/threonine kinase activity;transferase activity carbohydrate metabolic process;cellular glucan metabolic process;cellular process;energy reserve metabolic process;generation of precursor metabolites and energy;glycogen metabolic process;metabolic process;polysaccharide metabolic process Calcium signaling pathway;Insulin signaling pathway 2 2 2 1.6 1.6 1.6 137.31 1.0861E-06 3116400 1736800 1379600 345 IPI:IPI00004247.2;IPI:IPI00938084.1 Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform PHKA1;PHKA P46020-1;P46020;P46020-2 ENST00000339490;ENST00000373539;ENST00000373542 K07190 2 0.74729 1.3432 0.76671 0.91367 0.93438 0.94598 ERG2_Sigma1R cell junction;endoplasmic reticulum membrane;growth cone;integral to membrane;integral to plasma membrane;lipid particle;membrane;monolayer-surrounded lipid storage body;nuclear inner membrane;nuclear outer membrane;organelle inner membrane;outer membrane binding;C-8 sterol isomerase activity;catalytic activity;drug binding;intramolecular oxidoreductase activity;intramolecular oxidoreductase activity, transposing C=C bonds;isomerase activity;receptor activity;signal transducer activity alcohol metabolic process;ergosterol biosynthetic process;ergosterol metabolic process;lipid biosynthetic process;lipid metabolic process;lipid transport;metabolic process;steroid biosynthetic process;steroid metabolic process;transport 2 2 2 8.5 8.5 8.5 25.127 0.0003072 131580000 69980000 61596000 346 IPI:IPI00218268.4;IPI:IPI00004267.3;IPI:IPI00376226.2;IPI:IPI00816436.1 Sigma 1-type opioid receptor;SR31747-binding protein;Aging-associated gene 8 protein OPRS1;SIGMAR1;SRBP;AAG8 Q99720-1;Q99720;Q99720-3;Q99720-4;Q99720-2 ENST00000277010;ENST00000353468;ENST00000360710 4 0.87541 1.6646 0.87993 1.1133 1.1337 1.1183 PWI;RRM_1 cell part;cytoplasm;intracellular organelle part;intracellular part;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part binding;mRNA binding;nucleic acid binding;nucleotide binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 9 9 9 13.2 13.2 13.2 100.18 2.4026E-87 914350000 482550000 431790000 347 IPI:IPI00004273.6;IPI:IPI00925670.1;IPI:IPI00924634.1;IPI:IPI00926163.1 RNA-binding protein 25;RNA-binding motif protein 25;RNA-binding region-containing protein 7;Arg/Glu/Asp-rich protein of 120 kDa;Protein S164 RBM25;RNPC7 P49756-1;P49756;P49756-4;P49756-3;P49756-2 ENST00000261973 4 0.53109 0.84222 NaN 0.71316 0.55041 NaN DUF1253 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle developmental process;multicellular organismal development;multicellular organismal process 2 2 2 3 3 3 87.054 1.6057E-06 15582000 8421900 7160400 348 IPI:IPI00004290.3 Digestive organ expansion factor homolog DEF;C1orf107 Q68CQ4 ENST00000367020 1 0.78734 1.3895 0.7838 1.0257 0.96781 1.0398 TRAPP cell part;cytoplasmic part;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle 6 6 6 37.8 37.8 37.8 20.274 4.4185E-69 322390000 166700000 155690000 350 IPI:IPI00004324.1 Trafficking protein particle complex subunit 3;BET3 homolog TRAPPC3;BET3;CDABP0066 O43617 ENST00000373166 1 0.72319 1.4429 0.72833 0.95453 0.87745 0.9392 BTB;zf-C2H2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transition metal ion binding;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 7 7 7 9.8 9.8 9.8 119.38 2.7549E-66 39969000 22109000 17859000 352 IPI:IPI00004337.2 Zinc finger and BTB domain-containing protein 11 ZBTB11 O95625 ENST00000312938 K10498 1 0.91689 1.7156 0.75242 1.1609 1.1306 1.0506 AF-4 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;transcription factor activity;transcription regulator activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent 5 5 5 6.9 6.9 6.9 127.46 3.3029E-78 5905100 3260000 2645100 354 IPI:IPI00004344.1;IPI:IPI00383219.2;IPI:IPI00658213.3 AF4/FMR2 family member 4;ALL1-fused gene from chromosome 5q31;Major CDK9 elongation factor-associated protein AFF4;AF5Q31;MCEF;HSPC092 Q9UHB7-1;Q9UHB7 ENST00000265343;ENST00000339039 3 0.73301 1.5667 0.77976 0.98906 1.0301 0.98476 Phosphorylase cell part;cytoplasm;intracellular part binding;catalytic activity;glycogen phosphorylase activity;lipid binding;phosphorylase activity;steroid binding;transferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring hexosyl groups;vitamin binding carbohydrate metabolic process;cellular glucan metabolic process;generation of precursor metabolites and energy;glycogen catabolic process;glycogen metabolic process;polysaccharide catabolic process;polysaccharide metabolic process Insulin signaling pathway;Starch and sucrose metabolism 29 29 24 34.9 34.9 29.2 96.695 5.9748E-291 757280000 402840000 354440000 356 IPI:IPI00004358.4;IPI:IPI00783313.2 Glycogen phosphorylase, brain form PYGB P11216 ENST00000216962 K00688 2 0.80743 1.3751 0.76939 1.0409 0.93557 1.0061 Pkinase cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle catalytic activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;receptor signaling protein serine/threonine kinase activity;signal transducer activity cellular biopolymer metabolic process;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process;response to stress 10 5 5 22.5 13.5 13.5 59.642 1.9494E-179 124010000 65733000 58277000 357 IPI:IPI00004363.1 STE20/SPS1-related proline-alanine-rich protein kinase;Serine/threonine-protein kinase 39;DCHT STK39;SPAK Q9UEW8 ENST00000355999 K08282 1 0.66333 1.3117 NaN 0.84874 0.88197 NaN Spc97_Spc98 centrosome;gamma-tubulin complex;gamma-tubulin large complex;gamma-tubulin ring complex;intracellular organelle;macromolecular complex;microtubule;microtubule organizing center;non-membrane-bounded organelle;organelle;spindle pole structural constituent of cytoskeleton;structural molecule activity anatomical structure formation;cellular component organization;cellular process;cytoskeleton organization;microtubule cytoskeleton organization;microtubule nucleation;microtubule-based process;organelle organization;protein complex assembly 6 6 6 12 12 12 76.088 8.0545E-10 9433900 5415200 4018700 358 IPI:IPI00004389.3 Gamma-tubulin complex component 4;Hgrip76 TUBGCP4;76P;GCP4 Q9UGJ1 ENST00000399460 1 0.88204 1.0968 0.82448 1.1789 0.72298 1.0881 NUDIX 8-oxo-7,8-dihydroguanine triphosphatase activity;binding;catalytic activity;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;protein binding;pyrophosphatase activity cellular process;DNA metabolic process;DNA repair;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to DNA damage stimulus;response to oxidative stress;response to stress 5 5 5 26.9 26.9 26.9 22.519 3.8568E-15 75026000 35704000 39322000 359 IPI:IPI00004392.3;IPI:IPI00759578.2;IPI:IPI00759462.3;IPI:IPI00396056.6 7,8-dihydro-8-oxoguanine triphosphatase;8-oxo-dGTPase;Nucleoside diphosphate-linked moiety X motif 1 NUDT1;MTH1 P36639-1;P36639;P36639-2;P36639-3;P36639-4 ENST00000343985;ENST00000397047;ENST00000397048;ENST00000397049 K03574 4 0.81254 1.5653 0.97091 1.0473 1.0383 1.1949 cell part;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part binding;enzyme binding;kinase binding;protein binding;protein domain specific binding;SH2 domain binding cell communication;cellular process;immune response;immune system process;regulation of biological process;regulation of cellular process;regulation of immune system process;regulation of leukocyte activation;signal transduction 3 3 3 20.9 20.9 20.9 21.126 1.3984E-109 83221000 43748000 39472000 360 IPI:IPI00004407.1 Signaling threshold-regulating transmembrane adapter 1;Suppression-inducing transmembrane adapter 1;SHP2-interacting transmembrane adapter protein;gp30/40 SIT1;SIT Q9Y3P8 ENST00000259608 1 0.76331 1.8658 0.64606 0.95242 1.2225 0.86646 Aldolase_II cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane;non-membrane-bounded organelle;organelle;plasma membrane actin binding;binding;calmodulin binding;cation binding;cytoskeletal protein binding;ion binding;metal ion binding;protein binding;structural constituent of cytoskeleton;structural molecule activity 3 3 3 4.2 4.2 4.2 79.154 1.168E-07 9611500 5363900 4247600 361 IPI:IPI00004408.1;IPI:IPI00220754.1 Gamma-adducin;Adducin-like protein 70 ADD3;ADDL Q9UEY8-1;Q9UEY8;Q9UEY8-2 ENST00000277900;ENST00000356080;ENST00000360162 2 0.94077 1.7548 0.87518 1.1673 1.0451 1.1404 LSM cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;ribonucleoprotein complex binding;catalytic activity;nucleic acid binding;protein binding;RNA binding;RNA splicing factor activity, transesterification mechanism cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 5 5 5 48.9 48.9 48.9 15.179 3.4173E-34 191340000 97961000 93384000 362 IPI:IPI00004436.1 U6 snRNA-associated Sm-like protein LSm1;Cancer-associated Sm-like;Small nuclear ribonuclear CaSm LSM1;CASM O15116 ENST00000311351 1 0.5605 0.89955 0.51456 0.7332 0.60146 0.67259 RrnaAD cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;catalytic activity;methyltransferase activity;N-methyltransferase activity;nucleic acid binding;RNA binding;RNA methyltransferase activity;rRNA (adenine-N6,N6-)-dimethyltransferase activity;rRNA methyltransferase activity cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA modification;RNA processing;rRNA metabolic process;rRNA modification;rRNA processing 8 8 8 27.2 27.2 27.2 35.236 2.8192E-48 94509000 51633000 42875000 364 IPI:IPI00004459.1 Probable dimethyladenosine transferase;S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase;18S rRNA dimethylase;DIM1 dimethyladenosine transferase 1-like DIMT1L;DIMT1;HUSSY-05 Q9UNQ2 ENST00000199320 K02528 1 0.8357 1.6415 0.82061 1.1598 1.0657 1.0954 Pkinase cell part;cytoplasm;intracellular part ATP binding;binding;catalytic activity;enzyme inhibitor activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein kinase inhibitor activity;protein serine/threonine kinase activity;purine nucleoside binding cell communication;intracellular signaling cascade;ion transport;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein kinase cascade;protein modification process;signal transduction;transport 16 16 13 7.4 7.4 6.3 250.75 6.4661E-219 226140000 113080000 113050000 365 IPI:IPI00004472.1;IPI:IPI00397590.1;IPI:IPI00397592.1;IPI:IPI00398808.5;IPI:IPI00398811.1;IPI:IPI00398809.1;IPI:IPI00152474.8;IPI:IPI00387112.2;IPI:IPI00796716.2 Serine/threonine-protein kinase WNK1;Protein kinase with no lysine 1;Protein kinase, lysine-deficient 1;Erythrocyte 65 kDa protein;p65 WNK1;KDP;KIAA0344;PRKWNK1 Q9H4A3-1;Q9H4A3;Q9H4A3-2;Q9H4A3-4 ENST00000252477;ENST00000315939;ENST00000340908 K08867 9 0.99096 1.6814 0.92944 1.3076 1.084 1.2577 ATP-synt_F cell fraction;insoluble fraction;macromolecular complex;membrane fraction;proton-transporting two-sector ATPase complex;proton-transporting V-type ATPase complex;vacuolar proton-transporting V-type ATPase complex binding;catalytic activity;cation transmembrane transporter activity;hydrogen ion transmembrane transporter activity;ion transmembrane transporter activity;monovalent inorganic cation transmembrane transporter activity;protein binding;transporter activity ATP biosynthetic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;transport Epithelial cell signaling in Helicobacter pylori infection;Oxidative phosphorylation;Vibrio cholerae infection 5 5 5 39.5 39.5 39.5 13.37 1.1954E-15 188000000 93694000 94302000 366 IPI:IPI00004488.2 V-type proton ATPase subunit F;Vacuolar proton pump subunit F;V-ATPase 14 kDa subunit ATP6V1F;ATP6S14;VATF Q16864 ENST00000249289 K02151 1 NaN 0.92805 0.46917 NaN 0.61005 0.6212 MoeZ_MoeB;Rhodanese;ThiF cell part;cytoplasmic part;cytosol;intracellular part ATP binding;binding;catalytic activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;small protein activating enzyme activity;thiosulfate sulfurtransferase activity;transferase activity nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein modification process;RNA processing;tRNA metabolic process;tRNA modification;tRNA wobble base modification;tRNA wobble uridine modification 3 3 3 8.3 8.3 8.3 49.669 1.7879E-06 13062000 9409100 3653000 367 IPI:IPI00004489.1 Adenylyltransferase and sulfurtransferase MOCS3;Molybdenum cofactor synthesis protein 3;Molybdopterin synthase sulfurylase;Adenylyltransferase MOCS3;Sulfurtransferase MOCS3 MOCS3;UBA4 O95396 ENST00000244051 K11996 1 0.81004 1.458 0.75442 1.0274 0.97974 0.97349 Bcr-Abl_Oligo;C2;RhoGAP;RhoGEF cell part;intracellular catalytic activity;guanyl-nucleotide exchange factor activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;small GTPase regulator activity cell communication;intracellular signaling cascade;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;regulation of signal transduction;signal transduction Chronic myeloid leukemia;Pathways in cancer 13 13 12 14.1 14.1 13.3 142.82 1.6104E-141 145000000 77159000 67837000 368 IPI:IPI00004497.2;IPI:IPI00472302.2 Breakpoint cluster region protein;Renal carcinoma antigen NY-REN-26 BCR;BCR1;D22S11 P11274-1;P11274;P11274-2 ENST00000305877 K08878 2 0.79985 1.4788 0.87658 1.0373 0.99526 1.1105 SAM_2;SH3_2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 9 9 9 27.1 27.1 27.1 41.595 3.2201E-266 567850000 291280000 276570000 369 IPI:IPI00004504.1 SAM and SH3 domain-containing protein 3;SH3 protein expressed in lymphocytes homolog SASH3;CXorf9;SLY O75995 ENST00000356892 1 0.98221 1.2015 1.2025 1.286 0.83402 1.5158 K_tetra cation channel complex;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;ion channel complex;macromolecular complex;membrane-bounded organelle;nucleus;organelle;potassium channel complex;voltage-gated potassium channel complex binding;cation channel activity;cation transmembrane transporter activity;ion channel activity;potassium channel activity;protein binding;transporter activity;voltage-gated ion channel activity;voltage-gated potassium channel activity cation transport;establishment of localization;interspecies interaction between organisms;ion transport;metal ion transport;monovalent inorganic cation transport;multi-organism process;potassium ion transport;transport 4 4 4 22.6 22.6 22.6 26.092 2.5762E-16 52949000 25830000 27119000 370 IPI:IPI00004506.3 BTB/POZ domain-containing protein KCTD5 KCTD5 Q9NXV2 ENST00000301738 1 0.70949 NaN 0.70878 0.93476 NaN 0.94066 zf-A20;zf-AN1 binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding 4 4 3 20.2 20.2 13 22.555 4.642E-137 23323000 11656000 11667000 371 IPI:IPI00304660.3;IPI:IPI00004523.2 AN1-type zinc finger protein 6;Zinc finger A20 domain-containing protein 3;Associated with PRK1 protein ZFAND6;AWP1;ZA20D3;HT032 Q6FIF0-1;Q6FIF0;Q6FIF0-2 ENST00000261749 2 0.46967 0.82041 0.43643 0.61642 0.57519 0.58742 AIRS;AIRS_C cell part;cytoplasmic part;cytosol;intracellular part ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleoside binding;nucleotide binding;phosphoribosylformylglycinamidine synthase activity;protein binding;purine nucleoside binding 'de novo' IMP biosynthetic process;IMP biosynthetic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process 38 38 38 40.4 40.4 40.4 144.72 0 2188700000 1209000000 979650000 372 IPI:IPI00004534.4 Phosphoribosylformylglycinamidine synthase;Formylglycinamide ribotide amidotransferase;Formylglycinamide ribotide synthetase PFAS;KIAA0361 O15067 ENST00000314666 1 0.95468 3.1146 NaN 1.3448 2.0415 NaN WWE;zf-C3HC4 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;Notch binding;protein binding;protein domain specific binding;receptor binding;SH3 domain binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding;zinc ion binding cell communication;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;signal transduction;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent Notch signaling pathway 2 2 2 4.4 4.4 4.4 67.368 2.5871E-06 2333200 1225900 1107300 373 IPI:IPI00004554.2 Protein deltex-1 DTX1 Q86Y01 ENST00000257600 K06058 1 0.19659 0.40364 0.13735 0.25034 0.26243 0.1847 BTK;PH;Pkinase_Tyr;SH2;SH3_1 cell part;cytoplasmic part;cytosol;intracellular part;membrane;plasma membrane ATP binding;binding;catalytic activity;non-membrane spanning protein tyrosine kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein tyrosine kinase activity;purine nucleoside binding;zinc ion binding cell communication;cellular defense response;defense response;intracellular signaling cascade;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;response to stress;signal transduction Chemokine signaling pathway;Leukocyte transendothelial migration;T cell receptor signaling pathway 10 10 10 16.1 16.1 16.1 71.83 4.9336E-56 42407000 27824000 14582000 374 IPI:IPI00004566.1 Tyrosine-protein kinase ITK/TSK;T-cell-specific kinase;Tyrosine-protein kinase Lyk;Kinase EMT ITK;EMT;LYK Q08881 ENST00000231189 K07363 1 NaN NaN 0.56548 NaN NaN 0.7115 cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;histone-arginine N-methyltransferase activity;methyltransferase activity;N-methyltransferase activity;protein binding;protein methyltransferase activity;S-adenosylmethionine-dependent methyltransferase activity chromatin organization;DNA alkylation;DNA metabolic process;DNA methylation;DNA modification;genetic imprinting;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;spliceosomal snRNP biogenesis;transcription 2 2 2 2.9 2.9 2.9 78.458 2.5979E-05 12203000 6557200 5646300 375 IPI:IPI00004567.1;IPI:IPI00909654.1;IPI:IPI00643634.2 Protein arginine N-methyltransferase 7;Histone-arginine N-methyltransferase PRMT7;[Myelin basic protein]-arginine N-methyltransferase PRMT7 PRMT7;KIAA1933 Q9NVM4-1;Q9NVM4;Q9NVM4-3;Q9NVM4-4 ENST00000339507;ENST00000348497 K11438 3 0.89763 1.5525 0.83018 1.1778 1.0518 1.0382 FRG1 Cajal body;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nuclear body;nuclear speck;nucleolus;organelle;organelle part;ribonucleoprotein complex;spliceosomal complex cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing;rRNA processing 5 5 5 19 19 19 29.172 5.5706E-35 170640000 87728000 82910000 376 IPI:IPI00004655.1;IPI:IPI00001076.1 Protein FRG1;FSHD region gene 1 protein FRG1 Q14331 ENST00000226798 2 0.8672 1.934 0.76188 1.2259 1.1409 1.0908 C1-set early endosome membrane;endosome membrane;extracellular region;Golgi membrane;intracellular part;macromolecular complex;membrane;membrane part;MHC class I protein complex;MHC protein complex;organelle membrane;organelle part;protein complex binding;protein binding antigen processing and presentation;antigen processing and presentation of peptide antigen;antigen processing and presentation of peptide antigen via MHC class I;immune response;immune system process;response to stimulus Antigen processing and presentation 4 4 4 32.8 32.8 32.8 13.714 2.07E-38 240860000 121920000 118940000 377 IPI:IPI00004656.3 Beta-2-microglobulin;Beta-2-microglobulin form pI 5.3 B2M;CDABP0092;HDCMA22P P61769 ENST00000349264;ENST00000396754 K08055 1 0.88327 1.5509 0.94781 1.1436 0.99062 1.138 Glycos_transf_2;Ricin_B_lectin extracellular region;Golgi cisterna membrane;Golgi membrane;integral to Golgi membrane;integral to membrane;integral to organelle membrane;intrinsic to Golgi membrane;intrinsic to membrane;intrinsic to organelle membrane;membrane;organelle membrane acetylgalactosaminyltransferase activity;binding;calcium ion binding;catalytic activity;polypeptide N-acetylgalactosaminyltransferase activity;sugar binding;transferase activity;UDP-glycosyltransferase activity biosynthetic process;carbohydrate metabolic process;immunoglobulin biosynthetic process;macromolecule biosynthetic process;metabolic process;protein amino acid glycosylation;protein amino acid O-linked glycosylation;protein modification process O-Glycan biosynthesis 18 18 18 35.6 35.6 35.6 64.732 2.0413E-172 421620000 208920000 212700000 379 IPI:IPI00004669.1;IPI:IPI00339297.1 Polypeptide N-acetylgalactosaminyltransferase 2;Polypeptide GalNAc transferase 2;Protein-UDP acetylgalactosaminyltransferase 2;UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2;Polypeptide N-acetylgalactosaminyltransferase 2 soluble form GALNT2 Q10471 ENST00000366672 K00710 2 1.0368 2.2772 1.1003 1.4078 1.5356 1.4844 cytoplasmic part;ER-Golgi intermediate compartment;Golgi apparatus part;Golgi membrane;Golgi stack;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part binding;protein binding cellular component organization;cellular process;Golgi organization;organelle organization 18 18 18 7.7 7.7 7.7 376.01 1.9805E-160 98184000 46842000 51343000 380 IPI:IPI00004671.2 Golgin subfamily B member 1;Giantin;Macrogolgin;372 kDa Golgi complex-associated protein;GCP372 GOLGB1 Q14789 ENST00000340645 1 0.72131 1.512 0.66807 0.93859 1.0167 0.91417 ICln_channel cell part;cytoskeleton;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle;plasma membrane anion transport;blood circulation;cell volume homeostasis;cellular homeostasis;cellular process;chloride transport;circulatory system process;inorganic anion transport;ion transport;spliceosomal snRNP biogenesis;system process;transport 4 4 4 25.7 25.7 25.7 26.215 1.2636E-95 249380000 136140000 113240000 383 IPI:IPI00004795.1 Methylosome subunit pICln;Chloride conductance regulatory protein ICln;Chloride channel, nucleotide sensitive 1A;Chloride ion current inducer protein;Reticulocyte pICln CLNS1A;CLCI;ICLN P54105 ENST00000263309 K05019 1 0.74211 1.5626 0.84819 1.0096 1.0037 1.0983 SH2;SH3_1;SH3_2 cell part;cytoplasm;intracellular part;membrane;plasma membrane binding;catalytic activity;kinase activity;protein binding;protein kinase activity;protein tyrosine kinase activity;SH3/SH2 adaptor activity;signal transducer activity;transferase activity;transferase activity, transferring phosphorus-containing groups cell communication;cellular process;intracellular signaling cascade;JNK cascade;MAPKKK cascade;protein kinase cascade;Ras protein signal transduction;response to stress;signal transduction;small GTPase mediated signal transduction Chemokine signaling pathway;Chronic myeloid leukemia;ErbB signaling pathway;Focal adhesion;Insulin signaling pathway;MAPK signaling pathway;Pathways in cancer;Regulation of actin cytoskeleton;Renal cell carcinoma 12 12 12 44.6 44.6 44.6 33.777 1.6805E-159 552460000 282310000 270150000 385 IPI:IPI00004839.1 Crk-like protein CRKL P46109 ENST00000354336 K04438 1 0.91632 1.6532 0.96098 1.1287 1.1682 1.2377 NIPSNAP cell part;cytoplasmic part;cytosol;intracellular part 7 7 7 32.8 32.8 32.8 28.466 9.6168E-72 257190000 135830000 121360000 386 IPI:IPI00004845.4;IPI:IPI00020035.4 Protein NipSnap homolog 3A;NipSnap4;Target for Salmonella secreted protein C NIPSNAP3A;NIPSNAP4;HSPC299 Q9UFN0 ENST00000351220;ENST00000374767 2 NaN 1.2029 NaN NaN 0.7802 NaN BDHCT;DEAD;Helicase_C;HRDC;RQC chromosomal part;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;lateral element;non-membrane-bounded organelle;nuclear body;nuclear matrix;nuclear part;nucleolus;organelle;organelle part;PML body bubble DNA binding;DNA binding;DNA helicase activity;DNA secondary structure binding;DNA strand annealing activity;double-stranded DNA binding;nucleic acid binding;nucleoside binding;nucleotide binding;p53 binding;purine nucleoside binding cell cycle checkpoint;DNA damage checkpoint;double-strand break repair via homologous recombination;G2 phase of mitotic cell cycle;recombinational repair;regulation of cyclin-dependent protein kinase activity Homologous recombination 3 3 3 3 3 3 159 2.1932E-15 38711000 22260000 16450000 387 IPI:IPI00004859.1 Bloom syndrome protein;RecQ protein-like 3;DNA helicase, RecQ-like type 2 BLM;RECQ2;RECQL3 P54132 ENST00000355112 K10901 1 0.81597 1.7141 0.77602 1.0938 1.1156 1.0496 Arg_tRNA_synt_N;DALR_1;tRNA-synt_1d cell fraction;cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle;soluble fraction aminoacyl-tRNA ligase activity;arginine-tRNA ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-oxygen bonds;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding arginyl-tRNA aminoacylation;cellular amino acid and derivative metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;tRNA aminoacylation for protein translation;tRNA metabolic process Aminoacyl-tRNA biosynthesis 37 37 37 60 60 60 75.378 0 2347900000 1250500000 1097500000 388 IPI:IPI00004860.2;IPI:IPI00759723.1 Arginyl-tRNA synthetase, cytoplasmic;Arginine--tRNA ligase RARS P54136-1;P54136;P54136-2 ENST00000231572 K01887 2 0.78519 1.5505 0.80367 1.0118 1.0342 1.0377 ETF cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part electron carrier activity cellular metabolic process;cellular process;electron transport chain;establishment of localization;generation of precursor metabolites and energy;metabolic process;oxidation reduction;transport 16 16 16 41.3 41.3 41.3 37.434 1.9966E-188 1154800000 615290000 539510000 389 IPI:IPI00556451.2;IPI:IPI00004902.1 Electron transfer flavoprotein subunit beta ETFB;FP585 P38117-2;P38117;P38117-1 ENST00000309244;ENST00000354232 2 0.70875 1.4692 0.72092 0.99835 0.9221 0.97262 PH cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;nucleus;organelle;plasma membrane 14 14 14 30 30 30 73.91 6.7274E-207 558160000 296810000 261350000 390 IPI:IPI00004924.3 Differentially expressed in FDCP 6 homolog;IRF4-binding protein DEF6;IBP Q9H4E7 ENST00000316637 1 0.69422 1.4831 NaN 0.97071 0.92575 NaN 2OG-FeII_Oxy;zf-MYND cell part;cytoplasmic part;cytosol;intracellular part binding;catalytic activity;iron ion binding;oxidoreductase activity;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen;protein binding;zinc ion binding metabolic process;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to hypoxia;response to stress Pathways in cancer;Renal cell carcinoma 2 2 2 8 8 8 46.02 3.2587E-42 5567100 2995800 2571300 391 IPI:IPI00004928.1;IPI:IPI00328822.1 Egl nine homolog 1;Hypoxia-inducible factor prolyl hydroxylase 2;Prolyl hydroxylase domain-containing protein 2;SM-20 EGLN1;C1orf12;PNAS-118;PNAS-137 Q9GZT9-1;Q9GZT9;Q9GZT9-2 ENST00000366641 K09592 2 NaN 1.2022 NaN NaN 0.79935 NaN NOA36 chromosomal part;chromosome, centromeric region;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;midbody;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding 2 2 2 7.8 7.8 7.8 36.201 2.5129E-12 5841600 3256600 2584900 393 IPI:IPI00004942.1 Zinc finger protein 330;Nucleolar cysteine-rich protein;Nucleolar autoantigen 36 ZNF330;NOA36 Q9Y3S2 ENST00000262990 1 0.81047 1.4781 0.7873 1.0083 1.0163 1.0107 Prp19;U-box;WD40 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;protein complex;ribonucleoprotein complex;spliceosomal complex;ubiquitin ligase complex acid-amino acid ligase activity;binding;catalytic activity;DNA binding;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleic acid binding;protein binding;small conjugating protein ligase activity;ubiquitin-protein ligase activity DNA metabolic process;DNA repair;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein modification process;protein polyubiquitination;response to stress;RNA processing Ubiquitin mediated proteolysis 18 18 18 54.4 54.4 54.4 55.18 0 2658000000 1387900000 1270100000 394 IPI:IPI00004968.1 Pre-mRNA-processing factor 19;PRP19/PSO4 homolog;Nuclear matrix protein 200;Senescence evasion factor PRPF19;NMP200;PRP19;SNEV Q9UMS4 ENST00000227524 K10599 1 0.57202 1.0891 0.55536 0.7679 0.72397 0.72185 DRIM intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nucleolus;organelle;organelle part;ribonucleoprotein complex;small nucleolar ribonucleoprotein complex binding;protein binding biological regulation;negative regulation of biological process;negative regulation of cell proliferation;negative regulation of cellular process;regulation of biological process;regulation of cell proliferation;regulation of cellular process 35 35 35 14.2 14.2 14.2 318.4 2.1205E-192 307170000 166990000 140180000 395 IPI:IPI00004970.4 Small subunit processome component 20 homolog;Down-regulated in metastasis protein;Protein Key-1A6;Novel nucleolar protein 73 UTP20;DRIM O75691 ENST00000261637 1 NaN 0.9466 NaN NaN 0.59668 NaN zf-C2H2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;transcription factor activity;transcription regulator activity;transition metal ion binding;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 2 2 2 2.3 2.3 2.3 187.85 5.8587E-05 135570 66582 68992 396 IPI:IPI00005004.2 Zinc finger protein 142;HA4654 ZNF142;KIAA0236 P52746 ENST00000336124 1 0.89397 1.3595 NaN 1.0913 0.96359 NaN NOT2_3_5 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;general RNA polymerase II transcription factor activity;protein binding;RNA polymerase II transcription factor activity;RNA polymerase II transcription mediator activity;transcription regulator activity nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription from RNA polymerase II promoter, global;regulation of transcription, DNA-dependent;transcription 2 2 2 6.1 6.1 6.1 59.737 5.6304E-25 18711000 8804700 9906700 397 IPI:IPI00005011.1;IPI:IPI00410623.1;IPI:IPI00017733.2;IPI:IPI00410621.1 CCR4-NOT transcription complex subunit 2;CCR4-associated factor 2 CNOT2;CDC36;NOT2;HSPC131;MSTP046 Q9NZN8-1;Q9NZN8;Q9NZN8-4;Q9NZN8-5;Q9NZN8-2 ENST00000229195 4 0.81449 1.4361 0.81552 1.0025 1.0223 1.1903 NOT2_3_5;Not3 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding;transcription regulator activity biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 9 9 9 14.5 14.5 14.5 81.871 7.3448E-76 152550000 76408000 76141000 398 IPI:IPI00005015.1;IPI:IPI00478453.4;IPI:IPI00186188.6 CCR4-NOT transcription complex subunit 3;CCR4-associated factor 3;Leukocyte receptor cluster member 2 CNOT3;KIAA0691;LENG2;NOT3 O75175-1;O75175;O75175-2 ENST00000221232;ENST00000358389;ENST00000406403 3 1.0512 1.9156 NaN 1.4118 1.2012 NaN CP2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;protein binding;transcription cofactor activity;transcription corepressor activity;transcription factor activity;transcription factor binding;transcription repressor activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 3 3 3 8.9 8.9 8.9 60.49 1.7903E-77 3964200 2152100 1812000 399 IPI:IPI00005018.3;IPI:IPI00294870.4 Upstream-binding protein 1;LBP-1 UBP1;LBP1 Q9NZI7-1;Q9NZI7;Q9NZI7-4 ENST00000283628;ENST00000283629 K09275 2 0.59261 1.3303 0.56757 0.7918 0.84055 0.76269 DNA_pol_phi cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;NLS-dependent protein nuclear import complex;non-membrane-bounded organelle;nucleocytoplasmic shuttling complex;nucleolus;organelle;protein complex binding;catalytic activity;DNA binding;DNA-directed DNA polymerase activity;nucleic acid binding;protein binding;transcription factor binding;transferase activity;transferase activity, transferring phosphorus-containing groups biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleocytoplasmic transport;regulation of transcription, DNA-dependent;transcription;transport 46 46 46 37.7 37.7 37.7 149.37 0 2299500000 1268000000 1031500000 400 IPI:IPI00607584.1;IPI:IPI00005024.3 Myb-binding protein 1A MYBBP1A;P160 Q9BQG0-2;Q9BQG0;Q9BQG0-1 ENST00000254718;ENST00000381556 K02331 2 1.024 2.2793 1.6128 1.4049 1.5285 2.0856 G-patch;RRM_1;zf-RanBP cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;cation binding;DNA binding;ion binding;metal ion binding;mRNA binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding;transition metal ion binding;zinc ion binding anatomical structure formation;cell cycle;cellular process;negative regulation of cell proliferation;regulation of alternative nuclear mRNA splicing, via spliceosome;regulation of cell death;regulation of gene expression;spliceosome assembly 4 4 4 6.1 6.1 6.1 92.153 1.8922E-34 27194000 14599000 12595000 401 IPI:IPI00005036.1;IPI:IPI00930333.1;IPI:IPI00796867.1;IPI:IPI00927051.2 RNA-binding protein 5;RNA-binding motif protein 5;Putative tumor suppressor LUCA15;Protein G15;Renal carcinoma antigen NY-REN-9 RBM5;H37;LUCA15 P52756-1;P52756 ENST00000347869 4 1.0021 2.518 0.67345 1.3736 1.5798 0.86186 Ribonuc_L-PSP cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle catalytic activity;endonuclease activity;hydrolase activity;hydrolase activity, acting on ester bonds;nuclease activity posttranscriptional regulation of gene expression;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of translation;regulation of translational termination 3 3 3 23.4 23.4 23.4 14.494 3.9918E-10 177730000 99757000 77973000 402 IPI:IPI00005038.1 Ribonuclease UK114;14.5 kDa translational inhibitor protein;p14.5;UK114 antigen homolog HRSP12;PSP P52758 ENST00000254878 1 0.76642 1.3778 0.70959 0.98227 0.91883 0.91782 Acyl-CoA_dh_1;Acyl-CoA_dh_M;Acyl-CoA_dh_N cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part acyl-CoA dehydrogenase activity;binding;catalytic activity;electron carrier activity;nucleoside binding;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on the CH-CH group of donors;purine nucleoside binding catabolic process;cellular process;fatty acid beta-oxidation;fatty acid catabolic process;fatty acid metabolic process;lipid catabolic process;lipid metabolic process;metabolic process;organic acid catabolic process;organic acid metabolic process beta-Alanine metabolism;Fatty acid metabolism;PPAR signaling pathway;Propanoate metabolism;Valine, leucine and isoleucine degradation 14 14 14 37.6 37.6 37.6 47.019 7.6573E-89 595000000 315550000 279450000 403 IPI:IPI00895801.1;IPI:IPI00005040.1 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM P11310-2;P11310;P11310-1 ENST00000370834;ENST00000370841 K00249 2 0.50822 0.96716 0.50688 0.65576 0.61367 0.631 ABC_tran ATP-binding cassette (ABC) transporter complex;cytoplasmic part;envelope;intracellular organelle part;intracellular part;macromolecular complex;membrane part;mitochondrial envelope;mitochondrial part;organelle envelope;organelle part;protein complex ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity;transporter activity establishment of localization;transport 23 23 23 34.5 34.5 34.5 71.289 1.782E-201 913900000 521190000 392710000 404 IPI:IPI00005045.1 ATP-binding cassette sub-family F member 2;Iron-inhibited ABC transporter 2 ABCF2;HUSSY-18 Q9UG63 ENST00000222388;ENST00000287844 K06185 1 0.76391 NaN 0.94012 0.95481 NaN 1.1269 Ribosomal_S14 intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;mitochondrial ribosome;non-membrane-bounded organelle;organellar ribosome;organelle;organelle part;ribonucleoprotein complex;ribosome binding;protein binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 2 2 2 21.9 21.9 21.9 15.139 3.6537E-37 58613000 28940000 29673000 405 IPI:IPI00005050.1 28S ribosomal protein S14, mitochondrial;S14mt;MRP-S14 MRPS14 O60783 ENST00000367677 1 0.92771 1.7552 0.7763 1.2558 1.0307 1.1338 binding;protein binding 4 4 4 16.7 16.7 16.7 25.624 1.2076E-71 36212000 19627000 16585000 406 IPI:IPI00005055.4 UPF0428 protein CXorf56 CXorf56 Q9H5V9 ENST00000371594 1 0.81256 1.6679 0.83784 0.96452 1.1425 1.0241 GoLoco cell part;cytoplasm;intracellular part binding;enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity;protein binding biological regulation;cell communication;cellular process;regulation of biological process;regulation of cellular process;signal transduction 3 3 3 34.4 34.4 34.4 17.866 2.7392E-16 27811000 14659000 13153000 407 IPI:IPI00005064.1 G-protein-signaling modulator 3;Activator of G-protein signaling 4;Protein G18;G18.1b GPSM3;AGS4;C6orf9;G18 Q9Y4H4 ENST00000375040;ENST00000375043;ENST00000383132;ENST00000383134;ENST00000383265;ENST00000383269;ENST00000402726 1 0.97687 1.7526 NaN 1.2802 1.1594 NaN DUF580 cell part;integral to membrane;intrinsic to membrane;membrane part active transmembrane transporter activity;amine transmembrane transporter activity;choline transmembrane transporter activity;substrate-specific transmembrane transporter activity;transmembrane transporter activity;transporter activity amine transport;cation transport;choline transport;establishment of localization;ion transport;organic alcohol transport;organic cation transport;quaternary ammonium group transport;transport 3 3 3 6.4 6.4 6.4 73.301 1.9431E-05 4214000 1959500 2254500 408 IPI:IPI00221393.1;IPI:IPI00005068.2;IPI:IPI00642657.1 Choline transporter-like protein 1;Solute carrier family 44 member 1;CDw92 SLC44A1;CD92;CDW92;CTL1 Q8WWI5-1;Q8WWI5;Q8WWI5-2;Q8WWI5-3 ENST00000374720 K06515 3 1.4466 NaN 3.2503 2.004 NaN 4.7478 Asn_synthase asparagine synthase (glutamine-hydrolyzing) activity;carbon-nitrogen ligase activity, with glutamine as amido-N-donor;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds asparagine biosynthetic process;asparagine metabolic process;cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;glutamine metabolic process;nitrogen compound metabolic process;organic acid metabolic process 2 2 2 3.6 3.6 3.6 72.178 0.002854 808620 373360 435260 409 IPI:IPI00005084.4 Asparagine synthetase domain-containing protein 1;HCV NS3-transactivated protein 1 ASNSD1;NS3TP1;Nbla00058 Q9NWL6 ENST00000260952 1 0.84069 1.6673 0.86513 1.1219 1.0107 1.116 Tropomodulin cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle actin binding;binding;cytoskeletal protein binding;protein binding;tropomyosin binding 10 10 10 39.5 39.5 39.5 39.594 2.0255E-88 298720000 160250000 138480000 410 IPI:IPI00005087.1 Tropomodulin-3;Ubiquitous tropomodulin TMOD3 Q9NYL9 ENST00000308580 K10370 1 0.62883 1.4348 0.7436 0.84752 0.94928 0.98441 Spermine_synth catalytic activity;spermidine synthase activity;spermine synthase activity;transferase activity;transferase activity, transferring alkyl or aryl (other than methyl) groups cellular amino acid and derivative metabolic process;cellular amino acid derivative metabolic process;cellular amino acid metabolic process;methionine metabolic process;organic acid metabolic process;sulfur amino acid metabolic process Arginine and proline metabolism;beta-Alanine metabolism;Glutathione metabolism 8 8 8 35.5 35.5 35.5 41.268 2.0061E-19 234790000 128810000 105980000 411 IPI:IPI00005102.3;IPI:IPI00642393.1 Spermine synthase;Spermidine aminopropyltransferase SMS P52788-1;P52788;P52788-2 ENST00000265782;ENST00000404933 K00802 2 0.1781 0.63993 0.24953 0.24523 0.43933 0.33414 Pkinase cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;IkappaB kinase activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cellular process;I-kappaB phosphorylation;immune response;immune system process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein modification process Acute myeloid leukemia;Adipocytokine signaling pathway;Apoptosis;B cell receptor signaling pathway;Chemokine signaling pathway;Chronic myeloid leukemia;Epithelial cell signaling in Helicobacter pylori infection;MAPK signaling pathway;Pancreatic cancer;Pathways in cancer;Prostate cancer;Small cell lung cancer;T cell receptor signaling pathway;Toll-like receptor signaling pathway 8 8 8 11.1 11.1 11.1 84.653 4.9366E-39 19751000 13193000 6557700 412 IPI:IPI00005104.1 Inhibitor of nuclear factor kappa-B kinase subunit alpha;I-kappa-B kinase 1;Conserved helix-loop-helix ubiquitous kinase;Nuclear factor NF-kappa-B inhibitor kinase alpha CHUK;IKKA;TCF16 O15111 ENST00000370397 K04467 1 NaN 2.2019 0.084385 NaN 1.4804 0.10499 Patched endoplasmic reticulum;endosome membrane;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;late endosome membrane;lysosomal membrane;membrane;nuclear envelope;organelle membrane;vacuolar membrane binding;hedgehog receptor activity;lipid transporter activity;protein binding;receptor activity;signal transducer activity;sterol transporter activity;substrate-specific transporter activity;transmembrane receptor activity;transporter activity bile acid metabolic process;biosynthetic process;carboxylic acid metabolic process;cellular process;lipid metabolic process;lysosomal transport;metabolic process;organic acid metabolic process;steroid metabolic process;transport;vacuolar transport 2 2 2 2 2 2 142.17 2.562E-25 406820 304380 102440 413 IPI:IPI00005107.2 Niemann-Pick C1 protein NPC1 O15118 ENST00000269228 K12385 1 0.74847 1.5049 0.69728 0.99512 0.94397 0.91225 SCAMP cell part;cytoplasmic part;endosomal part;endosome membrane;Golgi apparatus part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part;trans-Golgi network binding;protein binding cellular process;establishment of localization;establishment of protein localization;Golgi vesicle transport;intracellular transport;post-Golgi vesicle-mediated transport;protein transport;transport;vesicle-mediated transport 3 3 3 14.8 14.8 14.8 37.92 7.9874E-53 117140000 64528000 52613000 414 IPI:IPI00005129.8;IPI:IPI00067352.1 Secretory carrier-associated membrane protein 1 SCAMP1;SCAMP O15126-1;O15126;O15126-2 ENST00000339292;ENST00000399194 2 0.59537 1.0809 0.50069 0.76339 0.77244 0.64484 MMR_HSR1 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cellular component biogenesis;cellular process;ribonucleoprotein complex biogenesis;ribosome biogenesis 13 13 11 30.9 30.9 28.4 65.572 0 96461000 53105000 43356000 415 IPI:IPI00005132.3 Guanine nucleotide-binding protein-like 3-like protein GNL3L Q9NVN8 ENST00000336470;ENST00000360845;ENST00000396243 1 0.67581 1.3129 NaN 0.88853 0.83396 NaN TRM13 binding;catalytic activity;cation binding;ion binding;metal ion binding;methyltransferase activity;transferase activity;transferase activity, transferring one-carbon groups;transition metal ion binding;zinc ion binding cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;tRNA metabolic process;tRNA processing 2 2 2 5.2 5.2 5.2 54.246 1.6604E-05 1508200 827200 680960 416 IPI:IPI00005149.3 tRNA guanosine-2'-O-methyltransferase TRM13 homolog;tRNA [Gm4] methyltransferase;Coiled-coil domain-containing protein 76 CCDC76 Q9NUP7-1;Q9NUP7 ENST00000370141 1 0.72715 1.296 0.71007 0.94472 0.84575 0.9087 HMG_box;SSrecog cell part;chromosome;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleoplasm;organelle;organelle part binding;DNA binding;nucleic acid binding;protein binding DNA metabolic process;DNA repair;DNA replication;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;response to stress;transcription 32 32 32 36.5 36.5 36.5 81.074 0 4160600000 1911100000 2249500000 417 IPI:IPI00005154.1 FACT complex subunit SSRP1;Facilitates chromatin transcription complex subunit SSRP1;FACT 80 kDa subunit;FACTp80;Chromatin-specific transcription elongation factor 80 kDa subunit;Structure-specific recognition protein 1;Recombination signal sequence recognition protein 1;T160 SSRP1;FACT80 Q08945 ENST00000278412 K09272 1 0.84999 1.8662 0.87774 1.1117 1.2072 1.12 AAA;LON;Lon_C cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial nucleoid;mitochondrial part;nucleoid;organelle part ATP-dependent peptidase activity;binding;catalytic activity;DNA binding;endopeptidase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;RNA binding;serine-type endopeptidase activity;single-stranded RNA binding DNA metabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein complex assembly;proteolysis;response to hypoxia;response to oxidative stress;response to stress 29 29 29 34.6 34.6 34.6 106.49 7.8194E-185 900830000 475290000 425530000 418 IPI:IPI00005158.1 Lon protease homolog, mitochondrial;Lon protease-like protein;LONHs;Mitochondrial ATP-dependent protease Lon;Serine protease 15 LONP1;PRSS15 P36776 ENST00000360614 K08675 1 0.96186 1.8842 0.98539 1.2476 1.2862 1.2857 Actin Arp2/3 protein complex;cell part;cell projection;cytoplasm;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;organelle part;protein complex actin binding;adenyl nucleotide binding;ATP binding;binding;cytoskeletal protein binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cell motion;cellular process 28 28 28 57.9 57.9 57.9 44.76 0 2607800000 1365000000 1242800000 419 IPI:IPI00005159.3 Actin-related protein 2;Actin-like protein 2 ACTR2;ARP2 P61160 ENST00000260641;ENST00000377982 1 0.92726 1.9202 0.91384 1.2303 1.1916 1.2071 WD40 Arp2/3 protein complex;cell part;cytoplasm;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;organelle part;protein complex actin binding;binding;cytoskeletal protein binding;protein binding;structural constituent of cytoskeleton;structural molecule activity cell motion;cellular process;regulation of actin filament length;regulation of actin filament polymerization;regulation of actin polymerization or depolymerization;regulation of cellular metabolic process;regulation of metabolic process Regulation of actin cytoskeleton 19 19 18 59.1 59.1 53 40.949 0 2187600000 1145900000 1041700000 420 IPI:IPI00005160.3 Actin-related protein 2/3 complex subunit 1B;Arp2/3 complex 41 kDa subunit;p41-ARC ARPC1B;ARC41 O15143 ENST00000252725 K05757 1 0.99886 1.9538 0.97812 1.3458 1.2824 1.2923 P34-Arc Arp2/3 protein complex;cell part;cell projection;cytoplasm;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;organelle part;protein complex actin binding;binding;cytoskeletal protein binding;protein binding;structural constituent of cytoskeleton;structural molecule activity cell motion;cellular process Regulation of actin cytoskeleton 21 21 21 56 56 56 34.333 4.6867E-181 2634400000 1332500000 1301900000 421 IPI:IPI00005161.3 Actin-related protein 2/3 complex subunit 2;Arp2/3 complex 34 kDa subunit ARPC2;ARC34;PRO2446 O15144 ENST00000295685;ENST00000315717 K05758 1 1.0628 1.894 1.0322 1.3781 1.2831 1.3147 P21-Arc Arp2/3 protein complex;cell part;cell projection;cytoplasm;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;organelle part;protein complex actin binding;binding;cytoskeletal protein binding;protein binding;structural constituent of cytoskeleton;structural molecule activity cell motion;cellular process;regulation of actin filament length;regulation of actin filament polymerization;regulation of actin polymerization or depolymerization;regulation of cellular metabolic process;regulation of metabolic process Regulation of actin cytoskeleton 6 6 6 33.7 33.7 33.7 20.546 1.0893E-55 583900000 293290000 290610000 422 IPI:IPI00005162.3 Actin-related protein 2/3 complex subunit 3;Arp2/3 complex 21 kDa subunit ARPC3;ARC21 O15145 ENST00000228825;ENST00000392683 K05756 1 0.56871 1.0893 0.60146 0.71945 0.71653 0.73956 RNA_pol_A_bac;RNA_pol_L cell part;DNA-directed RNA polymerase complex;DNA-directed RNA polymerase I complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleolar part;nucleoplasm;organelle part;protein complex;RNA polymerase complex binding;catalytic activity;DNA binding;DNA-directed RNA polymerase activity;nucleic acid binding;nucleotidyltransferase activity;protein binding;RNA polymerase activity;transferase activity;transferase activity, transferring phosphorus-containing groups biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription;transcription from RNA polymerase I promoter;transcription, DNA-dependent 7 7 7 24.9 24.9 24.9 39.249 6.0208E-107 427900000 234850000 193050000 424 IPI:IPI00005179.1;IPI:IPI00217386.1 DNA-directed RNA polymerases I and III subunit RPAC1;DNA-directed RNA polymerases I and III 40 kDa polypeptide;RPC40;AC40;RPA39 POLR1C;POLR1E O15160-1;O15160;O15160-2 ENST00000304004;ENST00000372389 2 NaN 2.0852 1.0103 NaN 1.2808 1.4863 ubiquitin 4 4 4 10.3 10.3 10.3 56.895 9.9853E-121 100400000 54111000 46287000 426 IPI:IPI00005194.1 Ubiquitin domain-containing protein UBFD1;Ubiquitin-binding protein homolog UBFD1;UBPH O14562 ENST00000219638 1 0.76043 1.4673 0.72424 0.98849 0.99941 0.9901 DZF cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;DNA binding;double-stranded RNA binding;nucleic acid binding;protein binding;RNA binding;RNA polymerase II transcription factor activity;transcription regulator activity biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 16 16 16 50 50 50 43.062 0 2233200000 1209000000 1024100000 427 IPI:IPI00005198.2 Interleukin enhancer-binding factor 2;Nuclear factor of activated T-cells 45 kDa ILF2;NF45;PRO3063 Q12905 ENST00000361891;ENST00000368684 1 0.73529 1.5526 0.80237 0.92477 1.0407 1.0106 Cyt-b5 cell part;integral to membrane;intrinsic to membrane;membrane part binding;cation binding;heme binding;ion binding;iron ion binding;ligand-dependent nuclear receptor activity;lipid binding;metal ion binding;receptor activity;signal transducer activity;steroid binding;steroid hormone receptor activity;tetrapyrrole binding 5 4 4 16.6 13 13 26.17 3.7672E-59 106350000 57351000 48999000 428 IPI:IPI00005202.2 Membrane-associated progesterone receptor component 2;Progesterone membrane-binding protein;Steroid receptor protein DG6 PGRMC2;DG6;PMBP O15173 ENST00000296425;ENST00000394276 1 0.93858 1.9561 0.8467 1.2658 1.2143 1.1515 MoaE cell part;cytoplasmic part;cytosol;intracellular part;macromolecular complex;molybdopterin synthase complex;protein complex catalytic activity;Mo-molybdopterin synthase activity biosynthetic process;cellular aromatic compound metabolic process;cellular process;coenzyme biosynthetic process;coenzyme metabolic process;metabolic process;Mo-molybdopterin cofactor biosynthetic process;nitrogen compound metabolic process 4 4 4 28.7 28.7 28.7 20.944 1.5614E-74 67951000 35644000 32307000 429 IPI:IPI00005218.1 Molybdenum cofactor synthesis protein 2B;Molybdenum cofactor synthesis protein 2 large subunit;Molybdopterin-synthase large subunit;MOCO1-B MOCS2;MCBPE;MOCO1 O96007 ENST00000338412;ENST00000361377;ENST00000396954 1 0.83116 1.9474 0.92616 1.0438 1.2993 1.2481 RHD;TIG cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;transcription factor activity;transcription regulator activity nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription;transcription, DNA-dependent Axon guidance;B cell receptor signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;VEGF signaling pathway;Wnt signaling pathway 6 6 1 7.1 7.1 0.8 115.59 3.9173E-69 21710000 11291000 10419000 431 IPI:IPI00030369.1;IPI:IPI00005240.1;IPI:IPI00215624.1;IPI:IPI00215625.1;IPI:IPI00215627.1 Nuclear factor of activated T-cells, cytoplasmic 3;T-cell transcription factor NFAT4;NFATx NFATC3;NFAT4 Q12968-1;Q12968;Q12968-2;Q12968-3;Q12968-4;Q12968-6 ENST00000329524;ENST00000346183;ENST00000349223 K04446 5 0.71177 1.5934 0.63771 0.93341 1.0526 0.80027 HEAT cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part;protein complex binding cell differentiation;cellular developmental process;cellular process;developmental process;gamete generation;male gamete generation;multicellular organismal development;multicellular organismal process;reproductive process;spermatogenesis Proteasome 6 6 6 4.2 4.2 4.2 211.33 4.0513E-33 233470000 130740000 102720000 432 IPI:IPI00005260.4;IPI:IPI00783948.2;IPI:IPI00829629.1 Proteasome activator complex subunit 4;Proteasome activator PA200 PSME4;KIAA0077 Q14997-1;Q14997;Q14997-2;Q14997-3 ENST00000185162;ENST00000389993;ENST00000404125 K06699 3 NaN 1.1417 NaN NaN 0.77481 NaN DUF821;Filamin endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;membrane-enclosed lumen;organelle;organelle lumen;organelle part 2 2 2 4.6 4.6 4.6 58.042 6.9238E-15 2060000 1067200 992780 433 IPI:IPI00005270.8 KDEL motif-containing protein 1;Endoplasmic reticulum resident protein 58 KDELC1;EP58;UNQ1910/PRO4357 Q6UW63 ENST00000376004 1 0.90922 NaN 0.5736 1.1385 NaN 0.73463 Rad9 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 3'-5' exonuclease activity;binding;catalytic activity;deoxyribonuclease activity;exodeoxyribonuclease activity;exodeoxyribonuclease III activity;exonuclease activity;hydrolase activity;nuclease activity;protein binding cell cycle checkpoint;DNA damage checkpoint;DNA metabolic process;DNA repair;DNA replication;DNA replication checkpoint;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of DNA replication 3 3 3 7.4 7.4 7.4 42.547 0.00028366 540980 281450 259530 434 IPI:IPI00005277.4 Cell cycle checkpoint control protein RAD9A;DNA repair exonuclease rad9 homolog A RAD9A Q99638 ENST00000307980 K10994 1 NaN 1.6768 NaN NaN 1.1001 NaN CBS AMP-activated protein kinase complex;cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;protein complex ATP binding;binding;cAMP-dependent protein kinase inhibitor activity;enzyme activator activity;enzyme inhibitor activity;nucleoside binding;nucleotide binding;protein binding;protein kinase inhibitor activity;purine nucleoside binding alcohol metabolic process;carbohydrate metabolic process;glycogen metabolic process;polysaccharide metabolic process;positive regulation of protein amino acid phosphorylation;regulation of protein amino acid phosphorylation Adipocytokine signaling pathway;Insulin signaling pathway 3 1 1 6.2 3.2 3.2 63.065 2.4047E-26 1849000 1021300 827770 435 IPI:IPI00005367.1;IPI:IPI00646448.1 5'-AMP-activated protein kinase subunit gamma-2;H91620p PRKAG2 Q9UGJ0-1;Q9UGJ0;Q9UGJ0-3 ENST00000287878;ENST00000392801 K07200 2 0.7046 1.6077 0.78898 0.99896 1.0325 1.0615 RNA_pol_Rpb7_N cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part catalytic activity;DNA-directed RNA polymerase activity;nucleotidyltransferase activity;RNA polymerase activity;transferase activity;transferase activity, transferring phosphorus-containing groups biosynthetic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription 5 5 5 21 21 21 37.432 3.2252E-48 53619000 27889000 25730000 436 IPI:IPI00005477.3 DNA-directed RNA polymerase I subunit RPA43;Twist neighbor protein TWISTNB Q3B726 ENST00000222567 1 0.73192 NaN 0.98409 0.93675 NaN 1.2932 GPP34 cell part;cytoplasmic part;Golgi apparatus part;Golgi cisterna membrane;Golgi membrane;intracellular organelle part;intracellular part;membrane;organelle membrane;organelle part 5 5 4 20.1 20.1 15.8 33.81 7.9392E-130 19063000 10893000 8169900 437 IPI:IPI00005490.1 Golgi phosphoprotein 3;Coat protein GPP34 GOLPH3;GPP34 Q9H4A6 ENST00000265070 1 0.82602 1.287 0.73376 1.0644 0.84444 0.99155 WD40 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding 7 7 7 28.1 28.1 28.1 36.588 4.8464E-121 90339000 48030000 42309000 438 IPI:IPI00005492.2 WD repeat-containing protein 5;BMP2-induced 3-kb gene protein WDR5;BIG3 P61964 ENST00000358625 1 0.89728 1.4932 0.61642 1.183 0.96616 0.83259 Josephin;UIM cell part;cytoplasm;intracellular organelle part;intracellular part;nuclear matrix;nuclear part;nucleoplasm;organelle part binding;catalytic activity;hydrolase activity;protein binding DNA metabolic process;DNA repair;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleotide-excision repair;regulation of transcription, DNA-dependent;response to stress;transcription 4 4 4 10.9 10.9 10.9 43.417 9.0172E-25 30111000 15544000 14566000 439 IPI:IPI00005495.3;IPI:IPI00219863.4;IPI:IPI00219864.2 Ataxin-3;Machado-Joseph disease protein 1;Spinocerebellar ataxia type 3 protein ATXN3;ATX3;MJD;MJD1;SCA3 P54252-1;P54252;P54252-2;P54252-3 ENST00000359819;ENST00000393287 K11863 3 0.8116 1.4331 0.78657 1.0433 0.95016 0.99476 PHF5 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;small nuclear ribonucleoprotein complex;U2 snRNP binding;DNA binding;nucleic acid binding;transcription factor activity;transcription regulator activity nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile;transcription 7 7 7 68.2 68.2 68.2 12.405 2.0423E-206 574520000 302810000 271710000 440 IPI:IPI00005511.1 PHD finger-like domain-containing protein 5A;Splicing factor 3B-associated 14 kDa protein;SF3b14b PHF5A Q7RTV0 ENST00000216252 1 0.62852 1.2407 NaN 0.85021 0.81836 NaN CH adherens junction;cell junction;cell-substrate adherens junction;cell-substrate junction;cytoplasm;cytoskeleton;focal adhesion;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle actin binding;binding;cytoskeletal protein binding;protein binding biological adhesion;cell adhesion;cell-matrix adhesion;cell-substrate adhesion;cellular process Focal adhesion 6 6 6 20.2 20.2 20.2 37.485 5.6917E-11 42754000 24697000 18057000 441 IPI:IPI00005512.1;IPI:IPI00215934.1;IPI:IPI00552212.1 Gamma-parvin PARVG Q9HBI0-1;Q9HBI0;Q9HBI0-2;Q9HBI0-3 ENST00000356909 K06275 3 0.72443 1.3707 0.67232 0.94851 0.98454 0.87931 Ribosomal_L12 cytoplasmic part;intracellular part;large ribosomal subunit;macromolecular complex;mitochondrial large ribosomal subunit;mitochondrial part;organellar large ribosomal subunit;organelle part;ribonucleoprotein complex;ribosomal subunit binding;nucleic acid binding;protein binding;RNA binding;structural constituent of ribosome;structural molecule activity nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription;transcription from mitochondrial promoter;transcription, DNA-dependent;translation 13 13 5 36.7 36.7 12 48.099 1.1208E-143 582160000 313850000 268310000 442 IPI:IPI00005537.3 39S ribosomal protein L12, mitochondrial;5c5-2 MRPL12;RPML12 P52815 ENST00000333676 1 0.13185 NaN 0.10923 0.1775 NaN 0.1457 DNA_mis_repair;HATPase_c;HMG_box cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle adenyl nucleotide binding;ATP binding;binding;DNA binding;double-stranded DNA binding;mismatched DNA binding;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;purine nucleotide binding;ribonucleotide binding cell cycle;cellular process;DNA metabolic process;DNA repair;metabolic process;mismatch repair;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to DNA damage stimulus;response to stress 3 3 3 3.3 3.3 3.3 105.83 1.1536E-05 3258500 1736900 1521600 444 IPI:IPI00005541.1 PMS1 protein homolog 1;DNA mismatch repair protein PMS1 PMS1;PMSL1 P54277 ENST00000342075 K10864 1 NaN 0.81984 NaN NaN 0.56871 NaN C1_1;C1_3;DAGK_acc;DAGK_cat;RA ATP binding;binding;catalytic activity;diacylglycerol kinase activity;kinase activity;lipid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;transferase activity;zinc ion binding activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway;cell communication;cell surface receptor linked signal transduction;G-protein coupled receptor protein signaling pathway;signal transduction 2 2 2 2.9 2.9 2.9 101.15 1.9181E-21 659600 288680 370920 446 IPI:IPI00005565.2 Diacylglycerol kinase theta;Diglyceride kinase theta DGKQ;DAGK4 P52824 ENST00000273814;ENST00000405681 1 0.8106 0.29331 0.91377 1.1298 0.20746 1.1505 NT5C cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 5'-nucleotidase activity;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;magnesium ion binding;nucleotidase activity;nucleotide binding;phosphatase activity;pyrimidine nucleotide binding alcohol metabolic process;carbohydrate metabolic process;D-ribose metabolic process;monosaccharide metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;pyrimidine nucleotide metabolic process Nicotinate and nicotinamide metabolism;Purine metabolism;Pyrimidine metabolism 3 3 3 17.9 17.9 17.9 23.382 1.6199E-05 101710000 62024000 39687000 447 IPI:IPI00005573.3;IPI:IPI00386083.1 5'(3')-deoxyribonucleotidase, cytosolic type;Cytosolic 5',3'-pyrimidine nucleotidase;Deoxy-5'-nucleotidase 1 NT5C;DNT1;UMPH2 Q8TCD5-1;Q8TCD5 ENST00000245552 K01081 2 0.71028 1.183 NaN 0.91993 0.79398 NaN Dynamin_N early endosome membrane;endoplasmic reticulum;endosomal part;endosome membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;nucleus;organelle;organelle membrane;organelle part ATP binding;binding;calcium ion binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity 5 4 3 11.1 9.1 7 61.174 4.1197E-65 5559600 2798500 2761100 449 IPI:IPI00005578.1 EH domain-containing protein 4;Hepatocellular carcinoma-associated protein 10/11 EHD4;HCA10;HCA11;PAST4;FKSG7 Q9H223 ENST00000220325 1 1.0026 1.7294 1.0514 1.3187 1.2061 1.2471 Ndr cell part;cytoplasm;intracellular part cell differentiation;cellular process;developmental process;gamete generation;male gamete generation;negative regulation of cell growth;negative regulation of growth;regulation of cell growth;regulation of growth;reproductive process;spermatogenesis 8 8 8 26.9 26.9 26.9 41.408 3.0522E-209 260180000 129490000 130690000 450 IPI:IPI00005605.4;IPI:IPI00218503.1;IPI:IPI00218504.1 Protein NDRG3 NDRG3 Q9UGV2-1;Q9UGV2;Q9UGV2-2;Q9UGV2-3 ENST00000349004;ENST00000359675;ENST00000373773;ENST00000373803 3 0.80828 1.51 0.82604 1.0046 1.0099 1.0234 RRM_1;zf-CCCH Cajal body;cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;cation binding;ion binding;metal ion binding;nucleic acid binding;nucleotide binding;RNA binding;transition metal ion binding;zinc ion binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 7 7 7 30 30 30 27.872 3.895E-197 1884200000 973550000 910640000 452 IPI:IPI00005613.3;IPI:IPI00871981.1;IPI:IPI00102851.7;IPI:IPI00872091.1 Splicing factor U2AF 35 kDa subunit;U2 auxiliary factor 35 kDa subunit;U2 snRNP auxiliary factor small subunit;Splicing factor U2AF 26 kDa subunit;U2 auxiliary factor 26;U2 small nuclear RNA auxiliary factor 1-like protein 4;U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3 U2AF1;U2AF35;U2AFBP;U2AF1L4;U2AF1-RS3;U2AF1L3 Q01081;Q8WU68-1;Q8WU68;Q8WU68-2;Q8WU68-3 ENST00000291552;ENST00000380276;ENST00000292879;ENST00000378975 4 0.8143 1.5812 0.80745 1.0863 1.0265 1.0816 CH;PH;Spectrin cytoplasmic part;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;M band;membrane;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;plasma membrane;spectrin actin binding;binding;calmodulin binding;cytoskeletal protein binding;protein binding;structural constituent of cytoskeleton;structural molecule activity negative regulation of macromolecule metabolic process;negative regulation of metabolic process;negative regulation of organelle organization;regulation of actin polymerization or depolymerization;regulation of metabolic process 119 119 10 59.3 59.3 5.6 274.61 0 8745000000 4532200000 4212800000 453 IPI:IPI00005614.6;IPI:IPI00328230.2;IPI:IPI00384252.1;IPI:IPI00171635.3;IPI:IPI00478167.3;IPI:IPI00024657.1 Spectrin beta chain, brain 1;Spectrin, non-erythroid beta chain 1;Beta-II spectrin;Fodrin beta chain SPTBN1;SPTB2 Q01082-1;Q01082;Q01082-2 ENST00000333896;ENST00000356805;ENST00000389980 K06115 6 0.73161 1.4547 0.85164 0.99791 0.92079 1.1478 RRM_1 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;lysosome;lytic vacuole;membrane-bounded organelle;organelle;vacuole binding;nucleic acid binding;nucleotide binding;RNA binding;RNA polymerase II transcription factor activity;transcription regulator activity apoptosis;cell death;cellular process;defense response;induction of apoptosis;regulation of biosynthetic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;response to stress 8 5 4 34.4 25.6 19.5 41.59 5.633E-235 107730000 57729000 49998000 454 IPI:IPI00005615.1 Nucleolysin TIAR;TIA-1-related protein TIAL1 Q01085 ENST00000369092;ENST00000369093 1 0.55179 1.2357 0.53576 0.75272 0.81173 0.71871 Sel1;TPR_1;TPR_2 binding 4 4 4 3.3 3.3 3.3 175.48 2.5975E-59 7640300 4401200 3239200 455 IPI:IPI00005634.3 Tetratricopeptide repeat protein 37 TTC37;KIAA0372 Q6PGP7 ENST00000358746 1 0.59706 1.2765 0.58937 0.80437 0.8708 0.77181 RRM_1;SAP cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;nucleotide binding;RNA binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 11 5 5 14.9 7.3 7.3 107.47 6.516E-144 100780000 61466000 39314000 456 IPI:IPI00005648.1 Scaffold attachment factor B2 SAFB2;KIAA0138 Q14151 ENST00000252542 1 1.7791 0.78407 3.6358 2.527 0.54524 5.3676 IBN_N;Xpo1 cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;organelle part;pore complex;protein complex binding;protein binding;protein transporter activity;substrate-specific transporter activity;transporter activity anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;protein complex assembly;protein import into nucleus, docking 3 3 3 3.9 3.9 3.9 108.19 1.6218E-06 4358800 1641800 2716900 457 IPI:IPI00005651.3 Importin-13;Ran-binding protein 13;Karyopherin-13 IPO13;KIAA0724;RANBP13 O94829 ENST00000372343 1 0.78962 1.5841 0.80329 1.0169 1.0488 1.0316 Prefoldin_2 cell part;cytoplasmic part;cytosolic part;intracellular part;macromolecular complex;prefoldin complex;protein complex binding;chaperone binding;protein binding;unfolded protein binding anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;metabolic process;protein complex assembly;protein folding;protein metabolic process 12 12 12 73.6 73.6 73.6 14.582 4.2265E-72 661220000 356290000 304930000 458 IPI:IPI00005657.1 Prefoldin subunit 6;Protein Ke2 PFDN6;HKE2;PFD6 O15212 ENST00000374606;ENST00000374607;ENST00000374610;ENST00000383073;ENST00000383207;ENST00000395131;ENST00000399110;ENST00000399112;ENST00000399383;ENST00000399385 K04798 1 0.64684 1.3286 0.68038 0.87425 0.85615 0.88672 ubiquitin cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle acid-amino acid ligase activity;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;small conjugating protein ligase activity biopolymer metabolic process;biopolymer modification;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;protein metabolic process;protein modification process 6 6 6 43.3 43.3 43.3 17.776 6.9334E-89 190880000 102090000 88794000 459 IPI:IPI00005658.3 Ubiquitin-like protein 4A;Ubiquitin-like protein GDX UBL4A;DXS254E;GDX;UBL4 P11441 ENST00000369653;ENST00000369660 1 0.65999 1.1619 NaN 0.88373 0.82767 NaN JmjC;JmjN;PHD cell part;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;catalytic activity;iron ion binding;nucleic acid binding;oxidoreductase activity;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen;protein binding;transcription repressor activity;zinc ion binding chromatin organization;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein amino acid demethylation;protein modification process;regulation of transcription, DNA-dependent;transcription 4 4 4 4.2 4.2 4.2 120.72 1.5335E-06 5753000 3440600 2312400 461 IPI:IPI00005666.1;IPI:IPI00013205.6;IPI:IPI00440491.1 Lysine-specific demethylase 4A;JmjC domain-containing histone demethylation protein 3A;Jumonji domain-containing protein 2A KDM4A;JHDM3A;JMJD2;JMJD2A;KIAA0677 O75164 ENST00000372396 K06709 3 0.50298 0.92621 0.70727 0.67201 0.56358 0.88474 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 4 4 4 6.4 6.4 6.4 100.38 8.0866E-20 14198000 7664500 6533200 462 IPI:IPI00005667.5 NEDD4-binding protein 1 N4BP1;KIAA0615 O75113 ENST00000262384 1 0.78009 1.4699 0.74799 1.0366 0.93929 1.0267 D123 cell part;cytoplasm;intracellular part cell cycle arrest;cell cycle process;cellular process;positive regulation of biological process;positive regulation of cell proliferation;positive regulation of cellular process;regulation of cell proliferation;regulation of mitotic cell cycle 10 10 10 28.9 28.9 28.9 39.134 7.5707E-65 227060000 121810000 105250000 463 IPI:IPI00005670.6 Cell division cycle protein 123 homolog;HT-1080;PZ32 CDC123;C10orf7;D123 O75794 ENST00000281141 1 0.65777 1.2107 0.70512 0.85102 0.81535 0.87754 dsrm;G-patch;R3H cell part;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;DNA binding;double-stranded RNA binding;nucleic acid binding;RNA binding;specific transcriptional repressor activity;transcription regulator activity;transcription repressor activity biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 10 10 10 17.2 17.2 17.2 77.672 1.6014E-46 126320000 67602000 58713000 464 IPI:IPI00005675.3 NF-kappa-B-repressing factor;Transcription factor NRF;ITBA4 protein NKRF;ITBA4;NRF O15226 ENST00000304449;ENST00000371527 1 0.63191 1.1392 0.66022 0.81548 0.78351 0.81163 Acyltransferase cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;microbody;microbody membrane;microbody part;organelle;organelle membrane;organelle part;peroxisomal membrane;peroxisomal part acetyltransferase activity;acyltransferase activity;catalytic activity;glycerone-phosphate O-acyltransferase activity;O-acetyltransferase activity;O-acyltransferase activity;transferase activity;transferase activity, transferring acyl groups anatomical structure morphogenesis;carboxylic acid metabolic process;cellular process;developmental process;fatty acid metabolic process;lipid metabolic process;metabolic process;organ morphogenesis;organic acid metabolic process Glycerophospholipid metabolism 6 6 6 10.4 10.4 10.4 77.187 1.7356E-73 47461000 28326000 19135000 465 IPI:IPI00005677.1 Dihydroxyacetone phosphate acyltransferase;Glycerone-phosphate O-acyltransferase;Acyl-CoA:dihydroxyacetonephosphateacyltransferase GNPAT;DAPAT;DHAPAT O15228 ENST00000366647 K00649 1 0.83055 1.2545 0.68786 1.0304 0.90109 0.91799 Ribosomal_S12 intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;mitochondrial ribosome;non-membrane-bounded organelle;organellar ribosome;organelle;ribonucleoprotein complex;ribosomal subunit;ribosome;small ribosomal subunit binding;protein binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 4 4 4 33.3 33.3 33.3 15.173 1.405E-05 42247000 23505000 18742000 467 IPI:IPI00005692.1 28S ribosomal protein S12, mitochondrial;MRP-S12;MT-RPS12 MRPS12;RPMS12;RPSM12 O15235 ENST00000308018;ENST00000402029;ENST00000407800 1 0.83827 1.1129 0.78511 1.0418 0.787 0.97825 Metallophos cell part;histone methyltransferase complex;intracellular organelle part;intracellular part;macromolecular complex;methyltransferase complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;catalytic activity;enzyme binding;hydrolase activity;hydrolase activity, acting on ester bonds;iron ion binding;kinase binding;phosphatase activity;phosphoprotein phosphatase activity;protein binding;protein serine/threonine phosphatase activity carbohydrate metabolic process;cell cycle;cellular glucan metabolic process;cellular process;energy reserve metabolic process;generation of precursor metabolites and energy;glycogen metabolic process;metabolic process;polysaccharide metabolic process Focal adhesion;Insulin signaling pathway;Long-term potentiation;Regulation of actin cytoskeleton;Vascular smooth muscle contraction 19 2 2 52.2 5.6 5.6 38.518 0 144150000 70661000 73488000 468 IPI:IPI00218187.1;IPI:IPI00005705.1 Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Protein phosphatase 1C catalytic subunit PPP1CC P36873-2;P36873;P36873-1 ENST00000335007;ENST00000340766 K06269 2 0.85829 1.5327 NaN 1.1523 1.0501 NaN fn2;Lectin_C;Ricin_B_lectin cell part;integral to membrane;intrinsic to membrane;membrane part binding;calcium ion binding;carbohydrate binding;cation binding;ion binding;metal ion binding;molecular transducer activity;receptor activity;signal transducer activity;sugar binding cellular component organization;cellular process;endocytosis;establishment of localization;membrane invagination;membrane organization;transport;vesicle-mediated transport 2 2 2 1.9 1.9 1.9 166.65 1.1662E-24 3277600 1399900 1877700 469 IPI:IPI00005707.6 C-type mannose receptor 2;Macrophage mannose receptor 2;Urokinase-type plasminogen activator receptor-associated protein;Endocytic receptor 180 MRC2;ENDO180;KIAA0709;UPARAP Q9UBG0 ENST00000303375 K06560 1 0.79865 1.1553 NaN 0.97481 0.8184 NaN U-box;Ufd2P_core cell part;cytoplasm;intracellular part;macromolecular complex;protein complex;ubiquitin ligase complex acid-amino acid ligase activity;binding;catalytic activity;enzyme binding;ligase activity;ligase activity, forming carbon-nitrogen bonds;protein binding;small conjugating protein ligase activity;ubiquitin-protein ligase activity apoptosis;cell death;cellular process;death;metabolic process;programmed cell death;protein metabolic process;protein modification process;protein ubiquitination;response to abiotic stimulus;response to light stimulus;response to radiation;response to UV Ubiquitin mediated proteolysis 3 3 3 3.5 3.5 3.5 146.18 1.3484E-54 1573700 797240 776420 470 IPI:IPI00005715.5;IPI:IPI00555735.1;IPI:IPI00655534.3 Ubiquitin conjugation factor E4 B;Ubiquitin fusion degradation protein 2;Homozygously deleted in neuroblastoma 1 UBE4B;HDNB1;KIAA0684;UFD2 O95155-1;O95155;O95155-2;O95155-3 ENST00000253251;ENST00000343090;ENST00000377157 K10597 3 0.78152 1.714 0.84713 1.0815 1.0674 1.1187 Ras cell part;cytoplasmic part;endoplasmic reticulum;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleotide binding;pyrophosphatase activity cell communication;cellular process;establishment of protein localization;intracellular signaling cascade;protein transport;regulation of biological process;signal transduction;small GTPase mediated signal transduction;transport;vesicle-mediated transport 11 3 3 66.8 24.4 24.4 22.677 2.4451E-241 162720000 85310000 77411000 471 IPI:IPI00005719.1;IPI:IPI00334174.3;IPI:IPI00185217.4 Ras-related protein Rab-1A;YPT1-related protein RAB1A;RAB1 P62820-1;P62820;P62820-2 ENST00000342609;ENST00000356214;ENST00000398529;ENST00000409784 K07874 3 0.89475 1.6766 0.84696 1.1968 1.1016 1.1556 ig;Pkinase_Tyr cell part;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part catalytic activity;nucleoside binding;nucleotide binding;protein kinase activity;protein tyrosine kinase activity;purine nucleoside binding;receptor activity;signal transducer activity;transmembrane receptor protein tyrosine kinase activity cell communication;cell surface receptor linked signal transduction;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;signal transduction Acute myeloid leukemia;Cytokine-cytokine receptor interaction;Hematopoietic cell lineage;Pathways in cancer 2 1 1 1.5 0.7 0.7 113.27 1.9002E-06 27027000 13641000 13386000 473 IPI:IPI00005722.5 FL cytokine receptor;Tyrosine-protein kinase receptor FLT3;Stem cell tyrosine kinase 1 FLT3;STK1 P36888 ENST00000241453;ENST00000380987 K05092 1 0.93625 1.7309 0.9536 1.1964 1.1359 1.198 LANC_like cell part;cytoplasm;integral to membrane;integral to plasma membrane;intracellular part;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part binding;catalytic activity;G-protein coupled receptor activity;low-density lipoprotein receptor binding;molecular transducer activity;protein binding;receptor activity;receptor binding;signal transducer activity;transmembrane receptor activity biological regulation;cell communication;cell surface receptor linked signal transduction;cellular process;G-protein coupled receptor protein signaling pathway;regulation of biological process;regulation of cellular process;signal transduction 10 10 10 28.1 28.1 28.1 45.283 2.8858E-65 499940000 256680000 243260000 474 IPI:IPI00005724.1 LanC-like protein 1;40 kDa erythrocyte membrane protein;p40 LANCL1;GPR69A O43813 ENST00000233714 1 0.80785 1.3565 0.93147 1.1094 0.80376 1.2791 Rer1 cytoplasmic part;Golgi apparatus part;integral to Golgi membrane;integral to membrane;integral to organelle membrane;intracellular part;intrinsic to Golgi membrane;intrinsic to membrane;intrinsic to organelle membrane;membrane part;organelle part cellular process;establishment of localization;establishment of localization in cell;Golgi vesicle transport;intracellular transport;retrograde vesicle-mediated transport, Golgi to ER;transport;vesicle-mediated transport 3 3 3 22.4 22.4 22.4 24.817 4.4351E-47 45198000 22993000 22206000 475 IPI:IPI00005728.2 Protein RER1 RER1 O15258 ENST00000306256 1 1.026 1.8976 1.0474 1.2522 1.3569 1.2918 SURF4 cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;ER-Golgi intermediate compartment;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part binding;protein binding 4 4 4 17.8 17.8 17.8 30.394 1.1243E-138 469150000 235890000 233260000 477 IPI:IPI00005737.1;IPI:IPI00641719.1 Surfeit locus protein 4 SURF4;SURF-4 O15260-1;O15260;O15260-2 ENST00000371989;ENST00000371991 2 0.79517 1.4063 0.59703 1.0061 1.0058 0.7295 UPF0172 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;nucleus;organelle 2 2 2 11 11 11 23.773 1.5523E-05 60232000 34265000 25968000 478 IPI:IPI00005740.1 Neighbor of COX4;Protein FAM158B COX4NB;C16orf4;COX4AL;FAM158B;NOC4 O43402 ENST00000253457 1 0.6944 1.237 0.67618 0.87948 0.80516 0.89495 Aminotran_1_2 cytoplasmic part;endoplasmic reticulum part;integral to membrane;intracellular part;intrinsic to membrane;macromolecular complex;membrane part;organelle part;palmitoyltransferase complex;protein complex;serine C-palmitoyltransferase complex acyltransferase activity;binding;C-acyltransferase activity;catalytic activity;C-palmitoyltransferase activity;lipid binding;palmitoyltransferase activity;protein binding;serine C-palmitoyltransferase activity;steroid binding;transferase activity biosynthetic process;cellular metabolic process;cellular process;lipid biosynthetic process;lipid metabolic process;membrane lipid metabolic process;metabolic process;sphingolipid biosynthetic process;sphingolipid metabolic process Sphingolipid metabolism 4 4 4 11.4 11.4 11.4 52.743 1.7024E-123 109250000 59317000 49935000 479 IPI:IPI00005745.1 Serine palmitoyltransferase 1;Serine-palmitoyl-CoA transferase 1;Long chain base biosynthesis protein 1 SPTLC1;LCB1 O15269 ENST00000262554 K00654 1 0.82708 1.3256 0.7858 1.0461 0.90491 1.0019 Aminotran_1_2 cytoplasmic part;endoplasmic reticulum part;integral to membrane;intracellular part;intrinsic to membrane;macromolecular complex;membrane part;organelle part;palmitoyltransferase complex;protein complex;serine C-palmitoyltransferase complex acyltransferase activity;binding;C-acyltransferase activity;catalytic activity;C-palmitoyltransferase activity;lipid binding;palmitoyltransferase activity;serine C-palmitoyltransferase activity;steroid binding;transferase activity biosynthetic process;cellular metabolic process;cellular process;lipid biosynthetic process;lipid metabolic process;membrane lipid metabolic process;metabolic process;sphingolipid biosynthetic process;sphingolipid metabolic process Sphingolipid metabolism 5 5 5 11.6 11.6 11.6 62.924 1.019E-79 30403000 16362000 14041000 481 IPI:IPI00005751.1 Serine palmitoyltransferase 2;Serine-palmitoyl-CoA transferase 2;Long chain base biosynthesis protein 2;Long chain base biosynthesis protein 2a SPTLC2;KIAA0526;LCB2 O15270 ENST00000216484 K00654 1 0.87797 1.4943 NaN 1.1602 0.99005 NaN CDP-OH_P_transf cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;nuclear membrane;nuclear part;organelle membrane;organelle part binding;catalytic activity;diacylglycerol cholinephosphotransferase activity;ethanolaminephosphotransferase activity;magnesium ion binding;transferase activity;transferase activity, transferring phosphorus-containing groups biosynthetic process;cellular metabolic process;cellular process;lipid biosynthetic process;lipid metabolic process;metabolic process;organophosphate metabolic process;phospholipid biosynthetic process;phospholipid metabolic process 2 2 2 6 6 6 46.553 4.3363E-12 20101000 10876000 9225000 482 IPI:IPI00005775.3 Choline/ethanolaminephosphotransferase 1 CEPT1;PRO1101 Q9Y6K0 ENST00000317584;ENST00000357172 1 NaN NaN 0.73636 NaN NaN 0.95067 Pkinase cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;MAP kinase kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;protein serine/threonine/tyrosine kinase activity;purine nucleoside binding cell communication;intracellular signaling cascade;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;response to stress;signal transduction;small GTPase mediated signal transduction MAPK signaling pathway;VEGF signaling pathway 5 3 3 15.4 10.2 10.2 42.987 1.8657E-08 26954000 12857000 14096000 483 IPI:IPI00005777.1;IPI:IPI00288889.3;IPI:IPI00044584.1 MAP kinase-activated protein kinase 3;Chromosome 3p kinase MAPKAPK3 Q16644 ENST00000357955 K04444 3 0.44049 0.90139 0.35566 0.60817 0.56325 0.48273 TPR_1 cell part;cytoplasmic part;cytosol;histone methyltransferase complex;intracellular organelle part;intracellular part;macromolecular complex;methyltransferase complex;nuclear part;nucleoplasm part;organelle part;protein complex acetylglucosaminyltransferase activity;binding;catalytic activity;protein binding;transferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring hexosyl groups;UDP-glycosyltransferase activity carbohydrate metabolic process;cell communication;metabolic process;protein amino acid glycosylation;protein amino acid O-linked glycosylation;protein modification process;response to external stimulus;response to nutrient;signal transduction O-Glycan biosynthesis 13 13 13 17.1 17.1 17.1 116.92 1.6264E-200 34109000 20923000 13186000 484 IPI:IPI00005780.3;IPI:IPI00607723.1;IPI:IPI00219856.1 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit;O-linked N-acetylglucosamine transferase 110 kDa subunit;O-GlcNAc transferase subunit p110 OGT O15294-1;O15294;O15294-3;O15294-2 ENST00000373701;ENST00000373719 K09667 3 0.94695 1.7209 0.90207 1.2907 1.0997 1.212 Ndc80_HEC condensed chromosome kinetochore;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;kinetochore;macromolecular complex;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle binding;protein binding cell communication;cytoskeleton organization;microtubule cytoskeleton organization;microtubule-based process;mitotic sister chromatid segregation;organelle organization;signal transduction;sister chromatid segregation;spindle organization 13 13 13 25.7 25.7 25.7 73.912 5.513E-64 149170000 77626000 71542000 485 IPI:IPI00005791.1 Kinetochore protein NDC80 homolog;Kinetochore protein Hec1;Kinetochore-associated protein 2;Highly expressed in cancer protein;Retinoblastoma-associated protein HEC NDC80;HEC;HEC1;KNTC2 O14777 ENST00000261597 K11547 1 0.8076 1.3782 0.77482 0.99866 0.97486 1.0158 RRM_1 cell part;cytoplasm;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding muscle system process;nuclear mRNA splicing, via spliceosome;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile;system process 8 8 8 29.1 29.1 29.1 32.749 2.466E-124 989480000 505690000 483790000 486 IPI:IPI00005792.2;IPI:IPI00414963.2 Polyadenylate-binding protein 2;Poly(A)-binding protein II;Polyadenylate-binding nuclear protein 1;Nuclear poly(A)-binding protein 1 PABPN1;PAB2;PABP2 Q86U42-1;Q86U42;Q86U42-2 ENST00000216727 2 NaN 1.4824 NaN NaN 1.0552 NaN Adaptin_N clathrin coated vesicle membrane;coated vesicle;coated vesicle membrane;COPI-coated vesicle;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle membrane;Golgi-associated vesicle;membrane;membrane coat;organelle membrane;vesicle membrane binding;protein binding;protein transporter activity;substrate-specific transporter activity;transporter activity cellular component organization;cellular process;endocytosis;intracellular protein transport;membrane invagination;membrane organization;post-Golgi vesicle-mediated transport;protein transport;transport;vesicle-mediated transport 5 3 3 6.5 3.9 3.9 119.06 3.6363E-08 1074200 651490 422740 487 IPI:IPI00005793.2 AP-3 complex subunit beta-2;Adapter-related protein complex 3 subunit beta-2;Adaptor protein complex AP-3 beta-2 subunit;AP-3 complex beta-2 subunit;Beta3B-adaptin;Clathrin assembly protein complex 3 beta-2 large chain;Neuron-specific vesicle coat protein beta-NAP AP3B2 Q13367 ENST00000261722 K12397 1 0.53369 1.1581 0.59175 0.66209 0.78413 0.75416 APC8;TPR_1 anaphase-promoting complex;cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nuclear ubiquitin ligase complex;nucleoplasm;organelle part;protein complex;ubiquitin ligase complex acid-amino acid ligase activity;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;small conjugating protein ligase activity;ubiquitin-protein ligase activity G1 phase of mitotic cell cycle;mitotic metaphase plate congression;mitotic metaphase/anaphase transition;proteolysis;regulation of exit from mitosis;regulation of mitosis;regulation of mitotic cell cycle;ubiquitin-dependent protein catabolic process Cell cycle;Cell cycle - yeast;Progesterone-mediated oocyte maturation;Ubiquitin mediated proteolysis 8 8 8 13.7 13.7 13.7 68.833 4.0068E-52 45679000 25551000 20128000 488 IPI:IPI00005822.2;IPI:IPI00939517.1;IPI:IPI00019237.4 Cell division cycle protein 23 homolog;Anaphase-promoting complex subunit 8;Cyclosome subunit 8 CDC23;ANAPC8 Q9UJX2-1;Q9UJX2;Q9UJX2-3 ENST00000209827;ENST00000394886 K03355 3 0.45808 0.95724 NaN 0.5643 0.67078 NaN Cyt-b5;HECT;MIB_HERC2;RCC1;ZZ anaphase-promoting complex;cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nuclear ubiquitin ligase complex;organelle part;protein complex;ubiquitin ligase complex acid-amino acid ligase activity;binding;catalytic activity;guanyl-nucleotide exchange factor activity;iron ion binding;ligase activity;ligase activity, forming carbon-nitrogen bonds;protein binding;ubiquitin-protein ligase activity;zinc ion binding catabolic process;cellular process;intracellular protein transport;macromolecule catabolic process;metabolic process;protein modification process;proteolysis;regulation of cell cycle process;regulation of mitosis;regulation of mitotic cell cycle;transport Ubiquitin mediated proteolysis 5 5 5 1.3 1.3 1.3 527.47 2.2113E-14 4383800 2122200 2261600 489 IPI:IPI00005826.1;IPI:IPI00398607.5 Probable E3 ubiquitin-protein ligase HERC2;HECT domain and RCC1-like domain-containing protein 2 HERC2 O95714 ENST00000261609 K10595 2 0.78648 1.7759 0.84467 1.0975 1.0921 1.084 PRP3;PWI cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;catalytic activity;protein binding;RNA splicing factor activity, transesterification mechanism nuclear mRNA splicing, via spliceosome;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile;system process 16 16 16 28.7 28.7 28.7 77.528 1.992E-199 509310000 283140000 226170000 491 IPI:IPI00005861.1;IPI:IPI00377152.1 U4/U6 small nuclear ribonucleoprotein Prp3;Pre-mRNA-splicing factor 3;U4/U6 snRNP 90 kDa protein PRPF3;HPRP3;PRP3 O43395-1;O43395;O43395-2 ENST00000324862 2 0.63882 1.0541 0.58084 0.76917 0.68813 0.73878 DEAD;Helicase_C Cajal body;cytoskeleton;cytosol;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nuclear body;organelle;organelle part;ribonucleoprotein complex;spliceosomal complex ATP binding;ATP-dependent RNA helicase activity;binding;catalytic activity;DNA binding;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;RNA helicase activity anatomical structure formation;assembly of spliceosomal tri-snRNP;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;ribonucleoprotein complex assembly 12 12 12 20.4 20.4 20.4 92.239 8.4706E-74 226310000 107400000 118920000 492 IPI:IPI00005904.3 Probable ATP-dependent RNA helicase DDX20;DEAD box protein 20;DEAD box protein DP 103;Component of gems 3;Gemin-3 DDX20;DP103;GEMIN3 Q9UHI6 ENST00000369702 1 0.74049 1.1547 0.69056 0.90735 0.82614 0.8765 FGGY_N cell part;cytoplasm;intracellular part ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups carbohydrate metabolic process;metabolic process;primary metabolic process Carbon fixation in photosynthetic organisms 6 6 6 17.2 17.2 17.2 51.504 1.6272E-68 127670000 67161000 60513000 493 IPI:IPI00005914.4 Sedoheptulokinase;Carbohydrate kinase-like protein SHPK;CARKL Q9UHJ6 ENST00000225519 K11214 1 0.94421 1.1587 0.67129 1.1563 0.80891 0.91526 IF-2B binding;catalytic activity;identical protein binding;intramolecular oxidoreductase activity;intramolecular oxidoreductase activity, interconverting aldoses and ketoses;isomerase activity;protein binding;S-methyl-5-thioribose-1-phosphate isomerase activity cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;methionine metabolic process;organic acid metabolic process;sulfur amino acid biosynthetic process;sulfur amino acid metabolic process;sulfur metabolic process 7 7 7 27.1 27.1 27.1 39.149 2.075E-32 112450000 62890000 49564000 494 IPI:IPI00005948.1;IPI:IPI00184525.2 Methylthioribose-1-phosphate isomerase;S-methyl-5-thioribose-1-phosphate isomerase;Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein MRI1;UNQ6390/PRO21135 Q9BV20-1;Q9BV20;Q9BV20-2 ENST00000040663;ENST00000319545 2 0.89817 1.7119 0.73498 1.2183 1.1951 1.0253 NDUFA12 cell part;cytoplasmic part;intracellular organelle part;intracellular part;membrane;membrane part;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part;respiratory chain catalytic activity;electron carrier activity;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH cellular process;electron transport chain;generation of precursor metabolites and energy;metabolic process;multicellular organismal process;respiratory gaseous exchange;response to oxidative stress;response to stress;transport 6 6 6 50 50 50 17.214 1.6413E-55 97626000 47451000 50175000 495 IPI:IPI00005966.6 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12;NADH-ubiquinone oxidoreductase subunit B17.2;Complex I-B17.2;13 kDa differentiation-associated protein NDUFA12;DAP13 Q9UI09 ENST00000327772 1 0.9688 1.5606 0.90111 1.2031 1.0906 1.159 F-actin_cap_A cell part;cytoskeletal part;F-actin capping protein complex;intracellular organelle part;intracellular part;macromolecular complex;organelle part;protein complex actin binding;binding;cytoskeletal protein binding;protein binding cell motion;cellular process;cytoskeleton organization;negative regulation of macromolecule metabolic process;negative regulation of metabolic process;organelle organization;protein complex assembly;regulation of actin polymerization or depolymerization 16 16 13 65.4 65.4 53.8 32.922 0 2516000000 1279300000 1236600000 496 IPI:IPI00005969.3 F-actin-capping protein subunit alpha-1;CapZ alpha-1 CAPZA1 P52907 ENST00000263168 K10364 1 0.79279 1.3944 0.83599 0.97504 0.98994 1.0227 RRM_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;nuclear body;nuclear part;nuclear speck;nucleoplasm part;nucleus;organelle;organelle part binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding;transcription cofactor activity;transcription corepressor activity;transcription factor binding;transcription regulator activity;transcription repressor activity nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 4 4 4 16.7 16.7 16.7 25.476 5.807E-150 2222300000 1077000000 1145300000 497 IPI:IPI00005978.8;IPI:IPI00477842.2;IPI:IPI00856075.1 Splicing factor, arginine/serine-rich 2;Splicing factor SC35;Splicing component, 35 kDa;Protein PR264;Splicing factor, arginine/serine-rich 2B;Pre-mRNA-splicing factor SRP46 SFRS2;SFRS2B;SRP46 Q01130;Q9BRL6-1;Q9BRL6;Q9BRL6-2 ENST00000392485 3 0.69656 1.1342 0.63291 0.87741 0.8158 0.81759 IF-2B cell part;cytoplasmic part;eukaryotic translation initiation factor 2B complex;intracellular part;macromolecular complex;protein complex binding;nucleic acid binding;protein binding;translation factor activity, nucleic acid binding;translation initiation factor activity;translation initiation factor binding;translation regulator activity axon ensheathment;ensheathment of neurons;ovarian follicle development;regulation of translation;regulation of translational initiation;response to heat;response to stress;response to temperature stimulus;translational initiation 12 12 12 28.9 28.9 28.9 59.714 1.9536E-94 117080000 64752000 52323000 498 IPI:IPI00220232.1;IPI:IPI00005979.2 Translation initiation factor eIF-2B subunit delta;eIF-2B GDP-GTP exchange factor subunit delta EIF2B4;EIF2BD Q9UI10-2;Q9UI10;Q9UI10-1 ENST00000347454 K03680 2 0.80657 1.6687 0.80424 1.1172 1.0469 1.071 Lsm_interact;RRM_1 cell part;cytoplasm;intracellular organelle part;intracellular part;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding cellular biopolymer metabolic process;cellular process;macromolecule metabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing 20 20 20 27.1 27.1 27.1 109.93 4.2061E-209 355140000 189600000 165540000 499 IPI:IPI00006025.1;IPI:IPI00719256.1 Squamous cell carcinoma antigen recognized by T-cells 3;Tat-interacting protein of 110 kDa SART3;KIAA0156;TIP110 Q15020-1;Q15020 ENST00000228284 2 NaN NaN 0.7629 NaN NaN 0.92802 FHA;Fork_head cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;magnesium ion binding;metal ion binding;nucleic acid binding;RNA polymerase II transcription factor activity;sequence-specific DNA binding;transcription factor activity;transcription regulator activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 3 2 2 4.2 2.4 2.4 69.061 0.00032649 6569800 3470200 3099600 501 IPI:IPI00006029.2;IPI:IPI00220426.2;IPI:IPI00479612.2 Forkhead box protein K2;Interleukin enhancer-binding factor 1;Cellular transcription factor ILF-1;FOXK1 FOXK2;ILF;ILF1 Q01167-1;Q01167;Q01167-2 ENST00000269384;ENST00000335241;ENST00000335255 K09404 3 NaN 0.50641 NaN NaN 0.31764 NaN 2 2 2 2.3 2.3 2.3 102.12 7.7621E-05 157620 42522 115100 502 IPI:IPI00006050.4;IPI:IPI00885016.1 Protein FAM115A FAM115A;KIAA0738 Q9Y4C2-1;Q9Y4C2;Q9Y4C2-2 ENST00000355951;ENST00000392900 2 0.73253 1.4227 0.76144 0.94236 0.95889 0.95354 Prefoldin_2 cell part;cytoplasmic part;cytosolic part;intracellular part;macromolecular complex;prefoldin complex;protein complex binding;protein binding;unfolded protein binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 8 8 8 68.8 68.8 68.8 16.648 7.8342E-98 830950000 427620000 403330000 503 IPI:IPI00006052.3 Prefoldin subunit 2 PFDN2;PFD2;HSPC231 Q9UHV9 ENST00000368010 K09549 1 NaN 1.2302 0.61516 NaN 0.86534 0.83351 HMG_box cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding 5 2 2 12.4 5.3 5.3 57.512 5.1345E-35 12700000 6938700 5761000 504 IPI:IPI00006065.4 Thymocyte selection-associated high mobility group box protein TOX;Thymus high mobility group box protein TOX TOX;KIAA0808 O94900 ENST00000361421 1 0.79824 1.5242 1.0122 0.99774 1.0161 1.2596 Rib_hydrolayse cell fraction;cell part;insoluble fraction;integral to membrane;intrinsic to membrane;membrane;membrane fraction;membrane part;plasma membrane binding;catalytic activity;hydrolase activity;hydrolase activity, acting on glycosyl bonds;hydrolase activity, hydrolyzing N-glycosyl compounds;molecular transducer activity;NAD+ nucleosidase activity;receptor activity;signal transducer activity cell communication;cellular process;induction of apoptosis;induction of apoptosis by extracellular signals;induction of programmed cell death;metabolic process;positive regulation of cell death;regulation of cell death;signal transduction Calcium signaling pathway;Nicotinate and nicotinamide metabolism 4 4 4 13.3 13.3 13.3 34.328 3.7329E-23 30339000 15604000 14735000 505 IPI:IPI00006071.4;IPI:IPI00395006.4 ADP-ribosyl cyclase 1;Cyclic ADP-ribose hydrolase 1;T10 CD38 P28907-1;P28907;P28907-2 ENST00000226279 K01242 2 0.39322 1.1188 0.49313 0.5397 0.68942 0.62821 TNFR_c6 cell part;cytoplasm;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;plasma membrane binding;molecular transducer activity;protein binding;receptor activity;signal transducer activity;transmembrane receptor activity cell communication;cellular process;negative regulation of cell proliferation;positive regulation of biosynthetic process;positive regulation of metabolic process;regulation of biosynthetic process;regulation of cytokine production;signal transduction Cytokine-cytokine receptor interaction 4 4 4 8.7 8.7 8.7 63.747 4.6463E-21 36544000 20499000 16045000 506 IPI:IPI00006073.1;IPI:IPI00759738.1 Tumor necrosis factor receptor superfamily member 8;CD30L receptor;Lymphocyte activation antigen CD30;KI-1 antigen TNFRSF8;CD30;D1S166E P28908-1;P28908 ENST00000263932 K05145 2 0.42625 1.1853 NaN 0.57415 0.77431 NaN EPL1;PHD cytoplasmic part;histone acetyltransferase complex;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;mitochondrion;nuclear part;organelle;organelle part;protein complex binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding cellular component organization;cellular process;chromatin modification;chromatin organization;covalent chromatin modification;histone modification;metabolic process;organelle organization;protein amino acid acetylation;protein modification process 2 2 2 3.5 3.5 3.5 93.807 1.3927E-18 1174500 643590 530920 507 IPI:IPI00006077.1;IPI:IPI00878910.2;IPI:IPI00792658.7;IPI:IPI00884143.1 Protein Jade-3;PHD finger protein 16;Protein Jade-2;PHD finger protein 15 PHF16;JADE3;KIAA0215;PHF15;JADE2;KIAA0239 Q92613;Q9NQC1-3;Q9NQC1;Q9NQC1-1;Q9NQC1-2 ENST00000218343;ENST00000397189;ENST00000282605;ENST00000395003 4 0.84924 1.6213 0.83844 1.0737 1.0918 1.1251 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;protein binding;transcription regulator activity;transcription repressor activity biosynthetic process;induction of apoptosis;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 12 12 12 15.7 15.7 15.7 106.12 2.0416E-33 832220000 438160000 394070000 508 IPI:IPI00006079.1;IPI:IPI00413671.1;IPI:IPI00413672.1;IPI:IPI00413673.1 Bcl-2-associated transcription factor 1 BCLAF1;BTF;KIAA0164 Q9NYF8-1;Q9NYF8;Q9NYF8-2;Q9NYF8-3;Q9NYF8-4 ENST00000031135;ENST00000353331;ENST00000392348 4 0.044412 42.443 0.020607 0.05561 30.173 0.024119 CH;efhand_1;efhand_2;Spectrin;WW;ZZ cell surface;costamere;cytoskeleton;dystrophin-associated glycoprotein complex;intracellular organelle;macromolecular complex;membrane;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle;plasma membrane;sarcolemma actin binding;binding;calcium ion binding;cation binding;cytoskeletal protein binding;enzyme binding;ion binding;protein binding;structural constituent of cytoskeleton;structural constituent of muscle;structural molecule activity;zinc ion binding biosynthetic process;cellular biosynthetic process;cellular metabolic process;cellular process;developmental process;metabolic process;muscle organ development;organ development;peptide biosynthetic process;peptide metabolic process + 4 3 3 1.2 1 1 426.69 0.00013647 1331900000 1267600000 64274000 510 IPI:IPI00006091.2;IPI:IPI00304639.3;IPI:IPI00304638.4;IPI:IPI00220577.5 Dystrophin DMD P11532-1;P11532;P11532-4;P11532-2;P11532-3 ENST00000357033;ENST00000361471;ENST00000378684;ENST00000378687 K10366 4 0.8091 1.4513 0.79693 1.13 1.0306 0.9977 PMM cell part;cytoplasm;intracellular part catalytic activity;intramolecular transferase activity;intramolecular transferase activity, phosphotransferases;isomerase activity;phosphomannomutase activity alcohol metabolic process;carbohydrate metabolic process;mannose metabolic process;monosaccharide metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein amino acid glycosylation;protein modification process Fructose and mannose metabolism 5 5 4 21.1 21.1 18.3 28.082 9.3459E-19 175440000 96372000 79071000 511 IPI:IPI00006092.1 Phosphomannomutase 2 PMM2 O15305 ENST00000268261 K01840 1 0.56716 0.98981 0.5649 0.74545 0.69767 0.75735 AARP2CN;DUF663 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex assembly;cellular macromolecular complex subunit organization;cellular process;ribonucleoprotein complex assembly;ribosome assembly 17 17 17 14.6 14.6 14.6 145.81 1.7121E-141 338230000 182390000 155840000 512 IPI:IPI00006099.1;IPI:IPI00874269.2;IPI:IPI00791193.2 Ribosome biogenesis protein BMS1 homolog;Ribosome assembly protein BMS1 homolog BMS1;BMS1L;KIAA0187 Q14692 ENST00000374518 3 0.77119 3.8468 0.96791 1.0335 2.7078 1.3094 GYF cell part;cytoplasm;intracellular part binding;protein binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 4 4 4 14.1 14.1 14.1 37.646 2.1153E-33 68776000 30914000 37862000 513 IPI:IPI00006103.1 CD2 antigen cytoplasmic tail-binding protein 2;CD2 cytoplasmic domain-binding protein;CD2 tail-binding protein CD2BP2;KIAA1178 O95400 ENST00000305596 1 0.54928 1.4694 0.75196 0.74398 0.92646 0.92768 RNA_POL_M_15KD cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;catalytic activity;DNA binding;DNA-directed RNA polymerase activity;nucleic acid binding;nucleotidyltransferase activity;transferase activity;transferase activity, transferring phosphorus-containing groups;zinc ion binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile Huntington's disease;RNA polymerase 6 6 6 52.8 52.8 52.8 14.523 1.9846E-121 162100000 86238000 75867000 514 IPI:IPI00006113.1 DNA-directed RNA polymerase II subunit RPB9;DNA-directed RNA polymerase II subunit I;DNA-directed RNA polymerase II 14.5 kDa polypeptide;RPB14.5 POLR2I P36954 ENST00000221859 K03017 1 0.66008 NaN 0.82815 0.8663 NaN 1.0958 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle binding;enzyme activator activity;enzyme regulator activity;protein binding 6 6 6 10 10 10 91.569 2.1839E-24 47043000 24186000 22858000 515 IPI:IPI00915443.1;IPI:IPI00006122.5;IPI:IPI00401163.6;IPI:IPI00515009.2;IPI:IPI00872345.1;IPI:IPI00915283.1;IPI:IPI00218139.3;IPI:IPI00915291.1 Cutaneous T-cell lymphoma-associated antigen 5;cTAGE family member 5;Meningioma-expressed antigen 6/11 CTAGE5;MEA11;MEA6;MGEA11;MGEA6 O15320-5;O15320;O15320-1;O15320-3;O15320-4;O15320-6;O15320-8;O15320-2;O15320-7 ENST00000280083;ENST00000341502;ENST00000341749;ENST00000348007;ENST00000382245;ENST00000396165 8 3.4386 4.601 2.4661 4.3696 3.0567 3.1892 binding;calcium ion binding;cation binding;ion binding;metal ion binding 3 3 3 5.7 5.7 5.7 55.031 1.9167E-16 6221400 2387200 3834300 516 IPI:IPI00006130.3 EF-hand domain-containing protein KIAA0494 KIAA0494 O75071 ENST00000371933 1 0.58841 1.7023 0.55389 0.84199 1.0424 0.81275 HMG14_17 cell part;chromatin;chromosomal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;chromatin binding;DNA binding;nucleic acid binding;transcription activator activity;transcription regulator activity biosynthetic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription 3 3 3 11.3 11.3 11.3 31.524 4.5812E-15 164930000 122820000 42106000 517 IPI:IPI00006157.1 Nucleosome-binding protein 1 NSBP1 P82970 ENST00000358130;ENST00000395452 1 0.83389 1.5769 0.77238 1.142 1.06 1.0332 PP2C cell part;cytoplasm;intracellular part;macromolecular complex;protein complex;protein serine/threonine phosphatase complex binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;magnesium ion binding;manganese ion binding;phosphatase activity;phosphoprotein phosphatase activity;protein serine/threonine phosphatase activity cellular biopolymer metabolic process;cellular process;dephosphorylation;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid dephosphorylation;protein metabolic process;protein modification process 14 14 14 38.8 38.8 38.8 42.906 1.71E-100 365070000 194730000 170340000 518 IPI:IPI00006164.4 Integrin-linked kinase-associated serine/threonine phosphatase 2C ILKAP Q9H0C8 ENST00000254654 1 0.66482 1.3998 0.75288 0.89044 0.90363 0.95886 PP2C cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;protein complex;protein serine/threonine phosphatase complex binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;magnesium ion binding;manganese ion binding;phosphatase activity;phosphoprotein phosphatase activity;protein serine/threonine phosphatase activity cell cycle arrest;cell cycle process;cellular process;dephosphorylation;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid dephosphorylation;protein metabolic process;protein modification process 12 12 12 32.6 32.6 32.6 59.271 1.9168E-121 693410000 371740000 321670000 519 IPI:IPI00006167.1 Protein phosphatase 1G;Protein phosphatase 2C isoform gamma;Protein phosphatase magnesium-dependent 1 gamma;Protein phosphatase 1C PPM1G;PPM1C O15355 ENST00000344034;ENST00000350803 K01090 1 0.62742 1.6261 NaN 0.83403 1.0518 NaN cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;RNA polymerase II transcription factor activity;specific RNA polymerase II transcription factor activity;transcription regulator activity defense response;inflammatory response;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to stress;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent 6 6 6 6.2 6.2 6.2 141.86 1.67E-07 21041000 12178000 8862900 520 IPI:IPI00006171.2;IPI:IPI00472161.2;IPI:IPI00479248.3 Nuclear factor related to kappa-B-binding protein;DNA-binding protein R kappa-B;INO80 complex subunit G NFRKB;INO80G Q6P4R8-2;Q6P4R8;Q6P4R8-1;Q6P4R8-3 ENST00000304521 K11671 3 0.77935 1.5748 0.65738 0.95884 1.0153 0.87617 FYVE;UIM;VHS cell part;cytoplasmic part;cytosol;early endosome membrane;endosomal part;endosome membrane;intracellular organelle part;intracellular part;late endosome membrane;membrane;multivesicular body membrane;organelle membrane;organelle part binding;cation binding;ion binding;metal ion binding;protein binding;protein domain specific binding;transition metal ion binding;zinc ion binding cell communication;cellular process;intracellular protein transport;negative regulation of cell proliferation;negative regulation of signal transduction;regulation of catabolic process;regulation of signal transduction;signal transduction;transport 10 10 10 12.9 12.9 12.9 86.191 7.8977E-78 203910000 110720000 93186000 521 IPI:IPI00006176.3;IPI:IPI00916785.1 Hepatocyte growth factor-regulated tyrosine kinase substrate;Protein pp110;Hrs HGS;HRS O14964-1;O14964;O14964-2 ENST00000329138 K12182 2 0.73502 1.4131 0.75109 0.97241 0.9384 0.98458 eIF-3_zeta cell part;cytoplasmic part;cytosol;eukaryotic translation initiation factor 3 complex;intracellular part;macromolecular complex;protein complex binding;nucleic acid binding;protein binding;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity cellular process;translational initiation 24 24 24 43.2 43.2 43.2 63.972 0 1894300000 1014800000 879550000 522 IPI:IPI00006181.1 Eukaryotic translation initiation factor 3 subunit D;Eukaryotic translation initiation factor 3 subunit 7;eIF-3-zeta;eIF3 p66 EIF3D;EIF3S7 O15371 ENST00000216190;ENST00000397177;ENST00000405442 K03251 1 0.82858 1.3884 0.73638 1.0328 1.0073 0.90929 Hist_deacetyl cell part;chromatin remodeling complex;cytoplasm;histone deacetylase complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;catalytic activity;histone deacetylase activity;hydrolase activity;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;protein binding;transcription factor binding chromatin organization;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein amino acid deacetylation;protein modification process;regulation of transcription, DNA-dependent;transcription 2 2 2 4.9 4.9 4.9 49.111 0.0019264 9257900 5180200 4077600 523 IPI:IPI00217965.1;IPI:IPI00006187.1 Histone deacetylase 3;RPD3-2;SMAP45 HDAC3 O15379-2;O15379;O15379-1 ENST00000305264 K11404 2 0.81945 1.5751 0.81051 1.0681 1.0331 1.0874 cell part;cytoskeletal part;intracellular organelle part;intracellular part;microtubule;organelle part;spindle microtubule;spindle pole structural molecule activity anaphase;cell cycle phase;cell cycle process;cellular component organization;cellular process;mitotic anaphase;nucleus organization;organelle organization 79 79 79 46.5 46.5 46.5 236.51 0 2613800000 1351300000 1262500000 524 IPI:IPI00006196.3;IPI:IPI00292771.4 Nuclear mitotic apparatus protein 1;SP-H antigen NUMA1;NUMA Q14980-2;Q14980;Q14980-1 ENST00000358965;ENST00000359652;ENST00000393695 2 0.49434 1.337 NaN 0.63114 0.95492 NaN AAA cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity 4 4 4 6.1 6.1 6.1 95.05 1.141E-59 26244000 4427400 21816000 525 IPI:IPI00006197.1;IPI:IPI00183080.1;IPI:IPI00185801.3 Nuclear valosin-containing protein-like NVL O15381-1;O15381;O15381-2;O15381-3 ENST00000281701;ENST00000340871;ENST00000361463;ENST00000391875 3 0.72276 1.5842 0.72909 0.95382 1.0111 0.92893 cell fraction;endoplasmic reticulum membrane;insoluble fraction;integral to membrane;integral to plasma membrane;intracellular part;intrinsic to membrane;intrinsic to plasma membrane;membrane;membrane fraction;organelle membrane;organelle part acetyl-CoA transporter activity;coenzyme transporter activity;cofactor transporter activity;transporter activity cell death;cellular process;death;establishment of localization;transport Glycosphingolipid biosynthesis - ganglio series 4 4 4 7.5 7.5 7.5 60.908 2.3613E-44 979030000 553160000 425870000 526 IPI:IPI00006205.1 Acetyl-coenzyme A transporter 1;Solute carrier family 33 member 1 SLC33A1;ACATN;AT1 O00400 ENST00000359479;ENST00000392845 K03372 1 0.78236 2.0632 0.78441 1.1143 1.1305 1.0974 Motile_Sperm endoplasmic reticulum membrane;Golgi apparatus;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intrinsic to membrane;membrane;membrane-bounded organelle;organelle;organelle membrane;organelle part;plasma membrane binding;cytoskeletal protein binding;enzyme binding;identical protein binding;protein binding;protein dimerization activity;protein heterodimerization activity;protein homodimerization activity;structural molecule activity;tubulin binding cell communication;cell death;cellular process;death;ER-nuclear signaling pathway;intracellular signaling cascade;response to biotic stimulus;response to organic substance;response to stress;response to unfolded protein;signal transduction 7 6 6 25.5 25.5 25.5 27.228 5.5729E-141 307770000 162220000 145540000 528 IPI:IPI00006211.4;IPI:IPI00748221.2 Vesicle-associated membrane protein-associated protein B/C;VAMP-B/VAMP-C VAPB;UNQ484/PRO983 O95292-1;O95292;O95292-2 ENST00000265619;ENST00000395802 K10707 2 0.61178 1.1583 0.59816 0.80752 0.7604 0.79558 cell part;centriolar satellite;cytoplasmic part;cytoskeletal part;intracellular organelle part;intracellular part;microtubule organizing center part;organelle part;pericentriolar material binding;protein binding anatomical structure formation;cell projection assembly;cell projection organization;cellular component assembly;cellular component organization;cellular process;cilium assembly;microtubule organizing center organization;organelle organization 24 24 24 15.9 15.9 15.9 228.48 7.8504E-180 222550000 121650000 100910000 529 IPI:IPI00006213.3;IPI:IPI00795923.3;IPI:IPI00001654.6 Pericentriolar material 1 protein PCM1 Q15154-1;Q15154;Q15154-2 ENST00000325083;ENST00000325126 3 0.78008 1.6915 0.82981 1.0714 1.1011 1.1131 tRNA_bind aminoacyl-tRNA synthetase multienzyme complex;cell part;extracellular region part;extracellular space;intracellular part;macromolecular complex;protein complex binding;cell surface binding;cytokine activity;identical protein binding;nucleic acid binding;protein binding;protein dimerization activity;protein homodimerization activity;receptor binding;RNA binding;tRNA binding immune system process;negative regulation of endothelial cell proliferation;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;regulation of endothelial cell proliferation;tRNA metabolic process 11 11 11 43.3 43.3 43.3 34.352 2.9228E-287 818520000 433740000 384770000 530 IPI:IPI00006252.3 Aminoacyl tRNA synthetase complex-interacting multifunctional protein 1;Multisynthetase complex auxiliary component p43;Endothelial monocyte-activating polypeptide 2;EMAP-II;Small inducible cytokine subfamily E member 1 AIMP1;EMAP2;SCYE1 Q12904 ENST00000358008;ENST00000394699;ENST00000394701 1 0.73761 1.6887 0.77976 0.93782 1.1304 1.011 Pro_isomerase cell part;intracellular organelle part;intracellular part;nuclear body;nuclear matrix;nuclear part;nuclear speck;nucleoplasm part;organelle part binding;catalytic activity;cis-trans isomerase activity;cyclosporin A binding;drug binding;isomerase activity;peptide binding;peptidyl-prolyl cis-trans isomerase activity cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein folding;protein metabolic process;RNA metabolic process;RNA processing;RNA splicing 9 9 9 12.9 12.9 12.9 88.616 2.8085E-149 284480000 147240000 137240000 532 IPI:IPI00006298.2;IPI:IPI00409624.1 Peptidyl-prolyl cis-trans isomerase G;Cyclophilin G;Clk-associating RS-cyclophilin;CASP10 PPIG Q13427-1;Q13427;Q13427-2 ENST00000260970 K09566 2 0.78554 1.5047 0.82875 1.1166 0.96316 1.2002 HTH_3;MBF1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;calmodulin binding;DNA binding;nucleic acid binding;protein binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding;transcription regulator activity biosynthetic process;metabolic process;multicellular organismal development;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 5 5 5 31.8 31.8 31.8 16.368 2.4922E-117 573680000 289560000 284120000 533 IPI:IPI00021570.1;IPI:IPI00006362.1 Endothelial differentiation-related factor 1;Multiprotein-bridging factor 1 EDF1 O60869-1;O60869;O60869-2 ENST00000224073;ENST00000371648 K03627 2 0.64553 1.4071 0.78114 0.90927 0.88869 1.0761 extracellular region 7 7 7 25.6 25.6 25.6 34.188 1.3217E-18 115730000 60506000 55224000 534 IPI:IPI00006372.3 Testis-expressed sequence 264 protein;Putative secreted protein ZSIG11 TEX264;ZSIG11;UNQ337/PRO536 Q9Y6I9 ENST00000341333;ENST00000395057 1 0.87385 1.3912 0.93172 1.2189 0.89282 1.2261 UMP1 cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;protein complex immune response;immune system process;response to stimulus Proteasome 7 7 7 57.4 57.4 57.4 15.789 2.6004E-101 422300000 208820000 213480000 535 IPI:IPI00006377.4 Proteasome maturation protein;Proteassemblin;Protein UMP1 homolog;Voltage-gated K channel beta subunit 4.1 POMP;C13orf12;UMP1;HSPC014;HSPC036;PNAS-110 Q9Y244 ENST00000380842 K11599 1 0.68469 1.6647 0.71893 0.90711 1.0879 0.95649 Nop;NOP5NT;NOSIC cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein import into nucleus;protein targeting;RNA processing;rRNA processing;snRNP protein import into nucleus;transport 26 26 26 49.7 49.7 49.7 59.578 0 2070500000 1112500000 957970000 536 IPI:IPI00006379.1 Nucleolar protein 58;Nucleolar protein 5 NOP58;NOL5;NOP5;HSPC120 Q9Y2X3 ENST00000264279 1 0.86673 1.7479 0.9091 1.1495 1.1197 1.1552 U-box cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;protein complex;ubiquitin ligase complex acid-amino acid ligase activity;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;protein binding;small conjugating protein ligase activity;ubiquitin-protein ligase activity cellular process;metabolic process;negative regulation of monooxygenase activity;protein metabolic process;protein modification by small protein conjugation;protein modification process;protein ubiquitination;regulation of monooxygenase activity 10 10 10 48.8 48.8 48.8 33.172 1.0975E-106 424110000 218660000 205450000 537 IPI:IPI00006408.4 Nitric oxide synthase-interacting protein;eNOS-interacting protein NOSIP;CGI-25 Q9Y314 ENST00000339093;ENST00000391853 1 0.5256 1.2685 0.58042 0.68565 0.7936 0.76457 TP_methylase catalytic activity;diphthine synthase activity;methyltransferase activity;S-adenosylmethionine-dependent methyltransferase activity;transferase activity;transferase activity, transferring one-carbon groups biosynthetic process;cellular process;metabolic process;peptidyl-amino acid modification;peptidyl-diphthamide biosynthetic process from peptidyl-histidine;peptidyl-diphthamide metabolic process;peptidyl-histidine modification;protein modification process 4 4 4 18.2 18.2 18.2 33.005 1.801E-33 62199000 33129000 29070000 538 IPI:IPI00375824.1;IPI:IPI00074270.1;IPI:IPI00375823.1;IPI:IPI00006419.7;IPI:IPI00375822.1 Diphthine synthase;Diphthamide biosynthesis methyltransferase DPH5;AD-018;CGI-30;HSPC143;NPD015 Q9H2P9-5;Q9H2P9;Q9H2P9-1;Q9H2P9-4;Q9H2P9-2;Q9H2P9-3 ENST00000251160;ENST00000342173;ENST00000370105;ENST00000370109 K00586 5 0.73614 1.545 NaN 0.97587 0.96335 NaN DnaJ cell part;integral to membrane;intrinsic to membrane;membrane part binding;heat shock protein binding;protein binding;unfolded protein binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular homeostasis;cellular metabolic process;cellular process;homeostatic process;macromolecule metabolic process;metabolic process;protein folding;protein metabolic process 3 3 3 5.1 5.1 5.1 90.59 2.8003E-18 3143600 1793500 1350100 539 IPI:IPI00006433.6;IPI:IPI00759581.1 DnaJ homolog subfamily C member 16 DNAJC16;KIAA0962 Q9Y2G8-1;Q9Y2G8;Q9Y2G8-2 ENST00000375847 K09536 2 0.64606 1.3961 0.677 0.85841 0.92533 0.94353 Ribosomal_S7 cytosolic small ribosomal subunit;intracellular membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;mitochondrion;organelle;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit binding;nucleic acid binding;protein binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 14 14 14 60.7 60.7 60.7 28.162 3.1125E-58 444930000 258040000 186890000 541 IPI:IPI00006440.6 28S ribosomal protein S7, mitochondrial;MRP-S7;bMRP-27a MRPS7 Q9Y2R9 ENST00000245539 1 0.80881 1.656 0.88372 1.0811 1.1144 1.1082 Cajal body;cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear body;nuclear part;nucleolus;nucleoplasm part;organelle;organelle part binding;protein binding;protein C-terminus binding 6 6 6 12.7 12.7 12.7 62.608 1.1545E-40 38692000 20962000 17729000 542 IPI:IPI00006442.1 Coilin;p80 COIL;CLN80 P38432 ENST00000240316 1 NaN 1.1768 0.94961 NaN 0.79599 1.2129 3HCDH;3HCDH_N binding;catalytic activity;oxidoreductase activity carboxylic acid metabolic process;cellular ketone metabolic process;cellular process;fatty acid metabolic process;lipid metabolic process;metabolic process;monocarboxylic acid metabolic process;organic acid metabolic process;oxoacid metabolic process 4 4 4 12.9 12.9 12.9 35.419 3.3598E-34 12846000 6022400 6823200 543 IPI:IPI00006443.3;IPI:IPI00645031.1 Lambda-crystallin homolog CRYL1;CRY Q9Y2S2-1;Q9Y2S2;Q9Y2S2-2 ENST00000298248 2 0.84198 1.6889 0.8476 1.1111 1.1525 1.1073 AAA;CDC48_2;CDC48_N cell part;cytoplasm;intracellular part ATP binding;ATP-dependent peptidase activity;binding;catalytic activity;endopeptidase activity;magnesium ion binding;nucleoside binding;nucleotide binding;peptidase activity;protein binding;purine nucleoside binding;serine-type endopeptidase activity biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;protein catabolic process;protein metabolic process;protein transport;proteolysis;transport 26 26 26 36.2 36.2 36.2 82.593 6.5144E-296 883820000 451960000 431860000 544 IPI:IPI00006451.7 Vesicle-fusing ATPase;N-ethylmaleimide-sensitive fusion protein;Vesicular-fusion protein NSF NSF P46459 ENST00000398238 K06027 1 0.75945 1.3473 0.74449 0.9637 0.90859 0.93239 Cation_ATPase_C;Cation_ATPase_N;E1-E2_ATPase;Hydrolase cell fraction;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;insoluble fraction;macromolecular complex;melanosome;membrane fraction;membrane-bounded organelle;membrane-bounded vesicle;organelle;sodium:potassium-exchanging ATPase complex;vesicle ATP binding;binding;catalytic activity;cation transmembrane transporter activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;sodium:potassium-exchanging ATPase activity;transporter activity ATP biosynthetic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;transport Cardiac muscle contraction 30 30 19 34.3 34.3 24.6 112.89 0 2036800000 1069800000 967040000 546 IPI:IPI00006482.1;IPI:IPI00414005.2;IPI:IPI00003021.1;IPI:IPI00375339.2;IPI:IPI00008161.8;IPI:IPI00872242.1;IPI:IPI00218919.7 Sodium/potassium-transporting ATPase subunit alpha-1;Na(+)/K(+) ATPase alpha-1 subunit ATP1A1 P05023-1;P05023;P05023-2 ENST00000295598;ENST00000339159 K01539 7 0.48287 1.2032 0.49952 0.60892 0.79066 0.69657 NTP_transferase cell part;cytoplasmic part;eukaryotic translation initiation factor 2B complex;intracellular part;macromolecular complex;protein complex binding;catalytic activity;nucleic acid binding;protein binding;transferase activity;transferase activity, transferring phosphorus-containing groups;translation factor activity, nucleic acid binding;translation initiation factor activity regulation of translation;regulation of translational initiation;response to abiotic stimulus;response to endogenous stimulus;response to heat;response to hormone stimulus;response to stress;response to temperature stimulus;translational initiation 10 10 10 27.9 27.9 27.9 50.24 1.2012E-40 72730000 40818000 31912000 547 IPI:IPI00006504.3;IPI:IPI00217227.3;IPI:IPI00332950.5 Translation initiation factor eIF-2B subunit gamma;eIF-2B GDP-GTP exchange factor subunit gamma EIF2B3 Q9NR50-1;Q9NR50;Q9NR50-2;Q9NR50-3 ENST00000360403 K03241 3 0.61229 1.2422 NaN 0.80602 0.78374 NaN UDG cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;nucleus;organelle binding;catalytic activity;DNA N-glycosylase activity;hydrolase activity;hydrolase activity, acting on glycosyl bonds;hydrolase activity, hydrolyzing N-glycosyl compounds;protein binding;uracil DNA N-glycosylase activity base-excision repair;cellular process;DNA metabolic process;DNA repair;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to DNA damage stimulus;response to stress Base excision repair;Primary immunodeficiency 4 1 1 20.1 3.9 3.9 33.924 1.321E-18 1461900 729720 732210 548 IPI:IPI00006516.1 Uracil-DNA glycosylase UNG;DGU;UNG1;UNG15 P13051-2;P13051 ENST00000242576;ENST00000336865 K03648 1 0.67667 1.907 0.81508 0.94495 1.2113 1.1028 CAF1 CCR4-NOT complex;cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex binding;DNA binding;molecular transducer activity;nucleic acid binding;protein binding;signal transducer activity;transcription factor activity;transcription regulator activity biosynthetic process;carbohydrate metabolic process;cell communication;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;signal transduction;transcription 6 6 5 29.8 29.8 27.4 32.745 9.7449E-46 55054000 28377000 26678000 550 IPI:IPI00006552.2 CCR4-NOT transcription complex subunit 7;CCR4-associated factor 1;BTG1-binding factor 1 CNOT7;CAF1 Q9UIV1 ENST00000361272 1 0.78346 1.4025 0.78997 1.0555 0.9365 1.0208 BAR;SH3_1 cytoplasmic part;Golgi apparatus part;Golgi membrane;intracellular organelle part;intracellular part;membrane;mitochondrial membrane;mitochondrial outer membrane;mitochondrial part;organelle membrane;organelle outer membrane;organelle part;outer membrane binding;identical protein binding;protein binding;protein dimerization activity;protein homodimerization activity anti-apoptosis;negative regulation of apoptosis;negative regulation of biological process;negative regulation of programmed cell death;regulation of apoptosis;regulation of cell death;regulation of programmed cell death 9 9 9 27.7 27.7 27.7 43.196 9.9101E-77 70615000 37361000 33254000 552 IPI:IPI00022824.1;IPI:IPI00006558.3 Endophilin-B1;SH3 domain-containing GRB2-like protein B1;Bax-interacting factor 1 SH3GLB1;KIAA0491;CGI-61 Q9Y371-2;Q9Y371;Q9Y371-1 ENST00000212369;ENST00000370558 K11248 2 0.46135 1.6417 NaN 0.68673 1.0575 NaN TUDOR;UBA cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding 4 4 4 9 9 9 83.102 5.8055E-06 6824100 5973400 850710 553 IPI:IPI00924692.1;IPI:IPI00006571.3;IPI:IPI00929228.1 Tudor domain-containing protein 3 TDRD3 Q9H7E2-3;Q9H7E2;Q9H7E2-1;Q9H7E2-2 ENST00000196169;ENST00000377881;ENST00000377894 3 NaN 0.80758 NaN NaN 0.55163 NaN DUF1394 cell part;intracellular 3 1 1 10.2 3.4 3.4 37.312 6.3864E-72 89231 32369 56862 554 IPI:IPI00006574.1 Protein FAM49A FAM49A Q9H0Q0 ENST00000355549;ENST00000381323;ENST00000406434 1 0.74226 1.6051 0.71956 0.9974 1.0047 0.96738 COX4 intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;mitochondrial inner membrane;mitochondrial membrane;nucleus;organelle;organelle inner membrane;organelle membrane;organelle part binding;catalytic activity;cation transmembrane transporter activity;cytochrome-c oxidase activity;heme-copper terminal oxidase activity;ion transmembrane transporter activity;protein binding;transporter activity cellular metabolic process;cellular process;generation of precursor metabolites and energy;metabolic process Alzheimer's disease;Cardiac muscle contraction;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 13 13 13 50.3 50.3 50.3 19.576 2.2723E-50 2335800000 1258000000 1077700000 555 IPI:IPI00006579.1 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial;Cytochrome c oxidase subunit IV isoform 1;Cytochrome c oxidase polypeptide IV COX4I1;COX4 P13073 ENST00000253452 K02263 1 0.71264 1.3533 0.43134 0.88184 0.88827 0.5762 HMG_box cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding 7 7 4 14.5 14.5 8.5 66.194 1.3405E-49 83216000 42991000 40225000 556 IPI:IPI00006586.1;IPI:IPI00787385.3;IPI:IPI00219264.1;IPI:IPI00043748.2 TOX high mobility group box family member 4;Epidermal Langerhans cell protein LCP1 TOX4;C14orf92;KIAA0737 O94842 ENST00000262709;ENST00000405508 4 0.69862 1.4051 0.75665 0.9503 0.93303 0.93705 cytoplasmic part;intracellular part;macromolecular complex;mitochondrial part;mitochondrial small ribosomal subunit;organellar small ribosomal subunit;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit biosynthetic process;cellular metabolic process;cellular process;DNA damage response, detection of DNA damage;metabolic process;peptide biosynthetic process;peptide metabolic process;response to DNA damage stimulus;response to stress 5 5 5 19.5 19.5 19.5 24.211 1.5349E-32 139300000 67380000 71918000 557 IPI:IPI00006606.1 28S ribosomal protein S26, mitochondrial;MRP-S26;MRP-S13 MRPS26;C20orf193;RPMS13 Q9BYN8 ENST00000380325 1 0.833 NaN 0.80252 1.0323 NaN 1.0261 DUF1193 extracellular region 5 5 5 15.9 15.9 15.9 46.432 6.7532E-37 11084000 5582300 5501300 559 IPI:IPI00006657.1 Protein FAM20B FAM20B;KIAA0475 O75063 ENST00000263733 1 0.83968 1.7656 0.88805 1.0649 1.1242 1.1029 Rotamase cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part catalytic activity;cis-trans isomerase activity;isomerase activity;peptidyl-prolyl cis-trans isomerase activity biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 6 6 6 40.4 40.4 40.4 16.608 3.7446E-135 349610000 171150000 178460000 560 IPI:IPI00006658.4;IPI:IPI00941201.1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4;Rotamase Pin4;PPIase Pin4;Peptidyl-prolyl cis/trans isomerase EPVH PIN4 Q9Y237-2;Q9Y237;Q9Y237-1 ENST00000218432;ENST00000373669 K09579 2 0.47712 0.82056 0.41364 0.58194 0.60154 0.52927 NUC201;NUC202 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle biosynthetic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription 13 13 1 14.9 14.9 0.9 124.87 1.3804E-262 166950000 95774000 71172000 564 IPI:IPI00006702.4 Proline-, glutamic acid- and leucine-rich protein 1;Modulator of non-genomic activity of estrogen receptor;Transcription factor HMX3 PELP1;HMX3;MNAR Q8IZL8-1;Q8IZL8 ENST00000301396 1 0.85117 2.473 1.0265 1.0624 1.5317 1.5171 DnaJ;TPR_1 cell part;cytoplasmic part;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle binding;enzyme inhibitor activity;enzyme regulator activity;heat shock protein binding;kinase inhibitor activity;kinase regulator activity;protein binding;protein kinase inhibitor activity;protein kinase regulator activity multi-organism process;response to biotic stimulus;response to chemical stimulus;response to organic substance;response to other organism;response to protein stimulus;response to stimulus;response to stress;response to unfolded protein;response to virus 12 12 12 28.4 28.4 28.4 57.579 1.3875E-92 51783000 27113000 24670000 565 IPI:IPI00006713.1 DnaJ homolog subfamily C member 3;Interferon-induced, double-stranded RNA-activated protein kinase inhibitor;Protein kinase inhibitor of 58 kDa;Protein kinase inhibitor p58 DNAJC3;P58IPK;PRKRI Q13217 ENST00000360638;ENST00000376795 K09523 1 0.75254 1.4812 0.72777 1.0394 0.92792 0.98075 Rad21_Rec8;Rad21_Rec8_N cell part;chromosome;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear chromosome;nuclear part;organelle;organelle part binding;protein binding apoptosis;DNA metabolic process;DNA recombination;DNA repair;double-strand break repair;nitrogen compound metabolic process;nuclear division;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to stress Cell cycle - yeast 11 11 10 24.2 24.2 23 71.689 2.1833E-69 150600000 78711000 71894000 566 IPI:IPI00006715.3 Double-strand-break repair protein rad21 homolog;Nuclear matrix protein 1;SCC1 homolog RAD21;HR21;KIAA0078;NXP1 O60216 ENST00000297338 K06670 1 0.83622 1.8872 0.91999 1.1614 1.2547 1.2133 Dynamin_N dendrite;integral to membrane;intrinsic to membrane;membrane;mitochondrial crista;mitochondrial intermembrane space;mitochondrial membrane;mitochondrial outer membrane;organelle envelope lumen;organelle membrane;organelle outer membrane;outer membrane binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;magnesium ion binding;nucleotide binding;pyrophosphatase activity apoptosis;inner mitochondrial membrane organization;membrane fusion;microtubule-based movement;microtubule-based process;mitochondrial fission;mitochondrial membrane organization;mitochondrion organization;organelle organization;system process;transport 13 13 13 15.4 15.4 15.4 115.88 6.4216E-55 244940000 132730000 112210000 567 IPI:IPI00107752.3;IPI:IPI00006721.4 Dynamin-like 120 kDa protein, mitochondrial;Optic atrophy protein 1;Dynamin-like 120 kDa protein, form S1 OPA1;KIAA0567 O60313-2;O60313;O60313-1 ENST00000361510;ENST00000361908;ENST00000392438 2 0.87758 1.4049 0.88627 1.1045 0.99917 1.0707 Pex16 endoplasmic reticulum membrane;integral to membrane;integral to organelle membrane;integral to peroxisomal membrane;intrinsic to membrane;intrinsic to organelle membrane;intrinsic to peroxisomal membrane;membrane;organelle membrane;organelle part binding;protein binding;protein C-terminus binding cellular process;intracellular protein transport;peroxisome membrane biogenesis;protein import;protein import into peroxisome matrix;protein targeting;protein targeting to membrane;protein targeting to peroxisome;protein transport;transport 3 3 3 10.4 10.4 10.4 39.283 2.4979E-16 46489000 23978000 22510000 568 IPI:IPI00386861.4;IPI:IPI00006722.1 Peroxisomal membrane protein PEX16;Peroxin-16;Peroxisomal biogenesis factor 16 PEX16 Q9Y5Y5-2;Q9Y5Y5;Q9Y5Y5-1 ENST00000241041;ENST00000378750 2 0.77429 1.485 0.814 1.048 1.026 1.0457 DEAD;Helicase_C cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;small nuclear ribonucleoprotein complex;U5 snRNP ATP binding;ATP-dependent helicase activity;ATP-dependent RNA helicase activity;binding;catalytic activity;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;RNA helicase activity anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;cis assembly of pre-catalytic spliceosome;ribonucleoprotein complex assembly Folate biosynthesis 22 22 22 28.3 28.3 28.3 95.581 2.2124E-100 1057700000 572260000 485390000 569 IPI:IPI00006725.2 Probable ATP-dependent RNA helicase DDX23;DEAD box protein 23;100 kDa U5 snRNP-specific protein;U5-100kD;PRP28 homolog DDX23 Q9BUQ8 ENST00000308025 K01529 1 0.48912 0.92821 0.49778 0.61296 0.63206 0.63159 CNH;Pkinase ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;small GTPase regulator activity;transferase activity cell communication;intracellular signaling cascade;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein kinase cascade;protein modification process;response to stress;signal transduction MAPK signaling pathway 10 10 5 9.6 9.6 5.5 150.91 2.5153E-93 188930000 104490000 84439000 570 IPI:IPI00219800.1;IPI:IPI00219802.1;IPI:IPI00006752.2;IPI:IPI00219799.2;IPI:IPI00639883.3;IPI:IPI00166680.1;IPI:IPI00218498.2;IPI:IPI00218497.2 Mitogen-activated protein kinase kinase kinase kinase 4;MAPK/ERK kinase kinase kinase 4;HPK/GCK-like kinase HGK;Nck-interacting kinase;Misshapen-like kinase 1;Mitogen-activated protein kinase kinase kinase kinase 6;MAPK/ERK kinase kinase kinase 6;GCK family kinase MiNK;Misshapen/NIK-related kinase MAP4K4;HGK;KIAA0687;NIK;MINK1;MAP4K6;MINK O95819-3;O95819;O95819-5;O95819-1;O95819-2;O95819-4;Q8N4C8-1;Q8N4C8;Q8N4C8-3;Q8N4C8-2 ENST00000324219;ENST00000347699;ENST00000350198;ENST00000350878;ENST00000347992;ENST00000355280 K04407 8 0.92541 1.585 0.99784 1.2134 1.0791 1.2966 WD40 cell part;cytoplasm;intracellular part binding;protein binding 8 8 8 26.6 26.6 26.6 38.926 2.7003E-104 255250000 129860000 125390000 571 IPI:IPI00006754.1 WD repeat-containing protein 68;WD repeat-containing protein An11 homolog WDR68;HAN11 P61962 ENST00000310827 K11805 1 0.67779 1.5902 0.62348 0.93048 1.0212 0.8857 APG5 autophagic vacuole;cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;organelle;pre-autophagosomal structure membrane;vacuole binding;protein binding anatomical structure formation;apoptosis;autophagic vacuole formation;cell death;cellular component organization;cellular process;death;metabolic process;organelle organization;programmed cell death;protein modification process;vesicle organization Regulation of autophagy 4 4 4 19.3 19.3 19.3 32.447 1.0194E-09 26818000 14915000 11903000 572 IPI:IPI00006800.3;IPI:IPI00220640.3 Autophagy protein 5;APG5-like;Apoptosis-specific protein ATG5;APG5L;ASP Q9H1Y0-1;Q9H1Y0;Q9H1Y0-2 ENST00000343245;ENST00000369076 K08339 2 0.83326 NaN NaN 1.1013 NaN NaN intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;mitochondrion;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 2 2 2 38.5 38.5 38.5 7.6191 3.4259E-31 9660300 5421800 4238500 573 IPI:IPI00006864.3 39S ribosomal protein L33, mitochondrial;L33mt;MRP-L33 MRPL33;C2orf1 O75394 ENST00000296102;ENST00000359603 1 0.93628 1.7987 0.90969 1.1595 1.236 1.1679 Synaptobrevin cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;endoplasmic reticulum membrane;ER-Golgi intermediate compartment membrane;Golgi membrane;integral to membrane;intrinsic to membrane;membrane;membrane-bounded vesicle;organelle membrane;vesicle binding;protein binding cellular process;ER to Golgi vesicle-mediated transport;establishment of localization;establishment of protein localization;Golgi vesicle transport;intracellular transport;protein transport;transport;vesicle-mediated transport SNARE interactions in vesicular transport 12 12 12 44.2 44.2 44.2 24.74 0 717280000 370940000 346340000 574 IPI:IPI00006865.3 Vesicle-trafficking protein SEC22b;SEC22 vesicle-trafficking protein homolog B;SEC22 vesicle-trafficking protein-like 1;ERS24;ERS-24 SEC22B;SEC22L1 O75396 K08517 1 0.63958 1.4841 0.85697 0.81087 0.86043 1.1204 Sas10_Utp3;Sas10_Utp3_C cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part brain development;cellular process;chromatin organization;negative regulation of gene expression;negative regulation of macromolecule metabolic process;negative regulation of metabolic process;organelle organization;regulation of gene expression 5 5 5 11.5 11.5 11.5 54.557 4.5883E-18 52644000 25452000 27192000 575 IPI:IPI00006900.1 Something about silencing protein 10;Disrupter of silencing SAS10;UTP3 homolog;Charged amino acid-rich leucine zipper 1 UTP3;CRLZ1;SAS10 Q9NQZ2 ENST00000254803 1 0.87751 1.714 0.78183 1.1384 1.1282 1.0679 PGAM cell part;intracellular carbohydrate phosphatase activity;catalytic activity;fructose-2,6-bisphosphate 2-phosphatase activity;hydrolase activity;hydrolase activity, acting on ester bonds;phosphatase activity;phosphoric ester hydrolase activity metabolic process 9 9 9 50.7 50.7 50.7 30.062 3.8304E-126 253180000 128660000 124520000 577 IPI:IPI00006907.1 Probable fructose-2,6-bisphosphatase TIGAR;TP53-induced glycolysis and apoptosis regulator TIGAR;C12orf5 Q9NQ88 ENST00000179259 1 0.78579 1.4862 0.87072 1.0238 0.99774 1.1182 LUC7 binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding 14 14 10 32.8 32.8 24.2 54.223 1.5538E-303 1233600000 623630000 609990000 578 IPI:IPI00006932.4;IPI:IPI00216804.1;IPI:IPI00418174.1 Putative RNA-binding protein Luc7-like 2 LUC7L2;CGI-59;CGI-74 Q9Y383-1;Q9Y383;Q9Y383-2 ENST00000263545;ENST00000354926 3 0.75072 1.4905 0.71653 1.012 0.92386 0.95058 Lactamase_B binding;catalytic activity;cation binding;hydrolase activity;ion binding;metal ion binding;transition metal ion binding;zinc ion binding 7 7 7 30.9 30.9 30.9 32.805 2.5738E-57 139060000 73185000 65879000 579 IPI:IPI00006952.3 Beta-lactamase-like protein 2 LACTB2;CGI-83 Q53H82 ENST00000276590 1 0.94603 1.8533 0.92416 1.1991 1.3263 1.155 adh_short binding;catalytic activity;oxidoreductase activity metabolic process;oxidation reduction 6 6 6 17.4 17.4 17.4 38.298 2.1072E-62 158780000 88164000 70618000 580 IPI:IPI00006957.3;IPI:IPI00339238.1 Dehydrogenase/reductase SDR family member 7;Retinal short-chain dehydrogenase/reductase 4 DHRS7;DHRS7A;RETSDR4;CGI-86;UNQ285/PRO3448 Q9Y394-1;Q9Y394;Q9Y394-2 ENST00000216500;ENST00000360557 K11165 2 0.76173 1.4267 NaN 0.93306 1.0258 NaN Ribosomal_S2 intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;mitochondrion;organelle;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 8 8 8 26.3 26.3 26.3 35.552 6.4394E-19 69657000 37006000 32651000 581 IPI:IPI00006970.2 28S ribosomal protein S2, mitochondrial;S2mt;MRP-S2 MRPS2;CGI-91 Q9Y399 ENST00000241600;ENST00000371785 1 0.75022 1.4303 0.64502 1.0064 0.94367 0.88472 Complex1_LYR cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle 2 2 2 14.3 14.3 14.3 10.758 0.00051853 35529000 19563000 15966000 582 IPI:IPI00006979.1 LYR motif-containing protein 4 LYRM4;C6orf149;CGI-203 Q9HD34 ENST00000330636 1 0.79863 1.5486 0.8394 1.0319 0.99659 1.0816 RLL cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle;perinuclear region of cytoplasm binding;identical protein binding;protein binding 16 16 16 71.3 71.3 71.3 28.068 0 1355900000 717300000 638620000 583 IPI:IPI00006980.1 UPF0568 protein C14orf166 C14orf166;CGI-99 Q9Y224 ENST00000261700 1 0.83112 1.5454 0.76428 1.1422 1.0363 1.0449 DEAD;Helicase_C cell part;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part ATP binding;ATP-dependent helicase activity;ATP-dependent RNA helicase activity;binding;catalytic activity;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;RNA binding;RNA helicase activity cellular biopolymer metabolic process;cellular process;macromolecule metabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process 22 22 22 27.5 27.5 27.5 96.331 8.6738E-210 848030000 431610000 416420000 584 IPI:IPI00006987.1 ATP-dependent RNA helicase DDX24;DEAD box protein 24 DDX24 Q9GZR7 ENST00000330836 1 0.75722 1.786 0.83342 1.0332 1.1837 1.1175 Ribosomal_L11;Ribosomal_L11_N structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 6 6 6 34.4 34.4 34.4 20.683 5.4372E-90 234180000 135360000 98828000 585 IPI:IPI00007001.1 39S ribosomal protein L11, mitochondrial MRPL11;CGI-113 Q9Y3B7 ENST00000310999 1 0.64051 1.1762 0.62479 0.8564 0.824 0.9078 Rrp15p binding;protein binding 4 4 4 14.2 14.2 14.2 31.484 1.3131E-17 205480000 99353000 106130000 586 IPI:IPI00007004.4 RRP15-like protein;Ribosomal RNA-processing protein 15 RRP15;KIAA0507;CGI-115 Q9Y3B9 ENST00000366932 1 0.77054 1.4792 0.74865 1.0297 1.0247 1.0123 Pro_isomerase cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex catalytic activity;cis-trans isomerase activity;isomerase activity;peptidyl-prolyl cis-trans isomerase activity cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein folding;RNA metabolic process;RNA processing;RNA splicing 5 5 5 37.3 37.3 37.3 18.237 1.1931E-73 665230000 350050000 315180000 587 IPI:IPI00007019.1 Peptidyl-prolyl cis-trans isomerase-like 1 PPIL1;CYPL1;CGI-124;UNQ2425/PRO4984 Q9Y3C6 ENST00000373699 K01802 1 0.78134 1.3363 0.79958 1.0792 0.89662 1.0255 DUF59 binding;protein binding 4 4 4 29.4 29.4 29.4 17.663 7.4223E-72 67420000 33868000 33552000 588 IPI:IPI00007024.1 UPF0195 protein FAM96B FAM96B;CGI-128;HSPC118 Q9Y3D0 ENST00000299761 1 0.05271 17.83 0.13536 0.067228 11.784 0.17435 efhand;S_100 binding;calcium ion binding;cation binding;ion binding;metal ion binding;protein binding defense response;inflammatory response;response to external stimulus;response to stimulus;response to stress;response to wounding + 6 6 6 52.7 52.7 52.7 10.834 2.4252E-24 113400000 110640000 2762500 589 IPI:IPI00007047.1 Protein S100-A8;S100 calcium-binding protein A8;Calgranulin-A;Migration inhibitory factor-related protein 8;Cystic fibrosis antigen;Leukocyte L1 complex light chain;Calprotectin L1L subunit;Urinary stone protein band A S100A8;CAGA;CFAG;MRP8 P05109 ENST00000368732;ENST00000368733 1 0.49357 1.7232 0.91658 0.65082 1.14 1.2104 integral to membrane;integral to mitochondrial outer membrane;integral to organelle membrane;integral to peroxisomal membrane;intrinsic to membrane;intrinsic to mitochondrial outer membrane;intrinsic to organelle membrane;intrinsic to peroxisomal membrane binding;protein binding anatomical structure morphogenesis;apoptosis;cell death;cellular component organization;cellular process;death;developmental process;mitochondrial fission;mitochondrion organization;organelle organization;peroxisome fission;programmed cell death 5 5 5 27 27 27 16.937 2.6709E-48 84545000 44577000 39968000 591 IPI:IPI00007052.6 Mitochondrial fission 1 protein;Fis1 homolog;Tetratricopeptide repeat protein 11;TPR repeat protein 11 FIS1;TTC11;CGI-135 Q9Y3D6 ENST00000223136 1 0.6614 1.2261 0.68694 0.83933 0.84199 0.85076 Pep_deformylase cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle binding;catalytic activity;hydrolase activity;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides;iron ion binding;peptide deformylase activity biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;peptidyl-amino acid modification;peptidyl-methionine modification;positive regulation of cell proliferation;protein modification process;translation 7 7 7 42.8 42.8 42.8 27.013 9.5014E-40 63243000 32782000 30461000 592 IPI:IPI00007060.1 Peptide deformylase, mitochondrial;Polypeptide deformylase PDF;PDF1A Q9HBH1 ENST00000288022 K01462 1 NaN NaN 0.74641 NaN NaN 0.99812 Got1 endoplasmic reticulum;Golgi membrane;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane;membrane-bounded organelle;organelle;organelle membrane;organelle part molecular transducer activity;signal transducer activity cellular process;positive regulation of cell communication;positive regulation of signal transduction;regulation of cell communication;regulation of protein kinase cascade;regulation of signal transduction;transport 2 2 2 19.6 19.6 19.6 15.425 1.2551E-46 22564000 13210000 9353900 593 IPI:IPI00007061.1 Vesicle transport protein GOT1B;Golgi transport 1 homolog B;Putative NF-kappa-B-activating protein 470 GOLT1B;GOT1A;CGI-141;HDCMA39P;UNQ432/PRO793 Q9Y3E0 ENST00000229314 1 0.74383 1.9366 0.78582 1.0697 1.151 1.1233 PWWP cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;growth factor activity;protein binding;receptor binding cell proliferation;cellular process 4 3 3 23.2 19.2 19.2 22.619 2.7027E-16 36478000 19975000 16502000 594 IPI:IPI00007063.5 Hepatoma-derived growth factor-related protein 3;Hepatoma-derived growth factor 2 HDGFRP3;HDGF2;CGI-142 Q9Y3E1 ENST00000299633 1 0.86906 1.6772 0.89818 1.1456 1.0807 1.185 tRNA_bind;tRNA-synt_1b cell fraction;cell part;cytoplasm;extracellular region part;extracellular space;intracellular part;soluble fraction aminoacyl-tRNA ligase activity;catalytic activity;G-protein-coupled receptor binding;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;RNA binding;signal transducer activity;tRNA binding;tyrosine-tRNA ligase activity cellular amino acid and derivative metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;tRNA aminoacylation for protein translation;tRNA metabolic process;tyrosyl-tRNA aminoacylation Aminoacyl-tRNA biosynthesis;Phenylalanine, tyrosine and tryptophan biosynthesis 37 37 37 72.7 72.7 72.7 59.143 0 4990900000 2555000000 2435900000 596 IPI:IPI00007074.5 Tyrosyl-tRNA synthetase, cytoplasmic;Tyrosyl--tRNA ligase YARS P54577 ENST00000373477 K01866 1 0.92284 1.7486 NaN 1.1367 1.1768 NaN Mito_carr integral to membrane;integral to plasma membrane;intracellular part;intrinsic to membrane;intrinsic to plasma membrane;membrane;membrane part;mitochondrial inner membrane;mitochondrial membrane;organelle inner membrane;organelle membrane;organelle part amine transmembrane transporter activity;amino acid transmembrane transporter activity;binding;calcium ion binding;L-glutamate transmembrane transporter activity;organic acid transmembrane transporter activity;transporter activity ATP biosynthetic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;transport 7 3 3 10.8 4.3 4.3 74.175 9.6525E-42 10406000 5481400 4924300 597 IPI:IPI00007084.3 Calcium-binding mitochondrial carrier protein Aralar2;Mitochondrial aspartate glutamate carrier 2;Solute carrier family 25 member 13;Citrin SLC25A13;ARALAR2 Q9UJS0 ENST00000265631 1 NaN 1.0289 0.65423 NaN 0.74929 0.78699 APC10 anaphase-promoting complex;cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nuclear ubiquitin ligase complex;nucleoplasm;organelle part;protein complex;ubiquitin ligase complex acid-amino acid ligase activity;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;protein binding;small conjugating protein ligase activity;ubiquitin-protein ligase activity catabolic process;cellular process;G2/M transition of mitotic cell cycle;macromolecule catabolic process;metabolic process;mitotic anaphase;proteolysis;regulation of mitosis;regulation of mitotic cell cycle;ubiquitin-dependent protein catabolic process Cell cycle;Cell cycle - yeast;Progesterone-mediated oocyte maturation;Ubiquitin mediated proteolysis 2 2 2 14.6 14.6 14.6 21.252 5.5678E-05 33810000 17918000 15892000 598 IPI:IPI00007088.6 Anaphase-promoting complex subunit 10;Cyclosome subunit 10 ANAPC10;APC10 Q9UM13 ENST00000309439 K03357 1 0.57024 1.0907 0.62292 0.72662 0.77622 0.79981 Ribosomal_S8e cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;ribonucleoprotein complex cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 5 5 5 22.7 22.7 22.7 30.065 4.2409E-67 140570000 75281000 65287000 599 IPI:IPI00007089.1 Ribosome biogenesis protein NSA2 homolog;TGF-beta-inducible nuclear protein 1;Hairy cell leukemia protein 1 TINP1;HUSSY-29 O95478 ENST00000296802 1 NaN 2.1628 0.65886 NaN 1.3033 0.87331 GKAP cell part;membrane binding;protein binding cell communication;cell-cell signaling;cellular process 2 2 2 1.9 1.9 1.9 108.01 0.0037021 1806600 953470 853130 602 IPI:IPI00220581.2;IPI:IPI00007138.2;IPI:IPI00411461.1 Disks large-associated protein 4;SAP90/PSD-95-associated protein 4;PSD-95/SAP90-binding protein 4 DLGAP4;DAP4;KIAA0964;SAPAP4 Q9Y2H0-2;Q9Y2H0;Q9Y2H0-1;Q9Y2H0-3 ENST00000339266;ENST00000340491;ENST00000373907;ENST00000373913;ENST00000401952 3 0.50067 1.1225 0.59953 0.66888 0.77135 0.74444 Psf2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding biosynthetic process;cellular process;DNA metabolic process;DNA replication;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3 3 3 20.5 20.5 20.5 21.427 9.7353E-05 20948000 10780000 10168000 604 IPI:IPI00007146.3 DNA replication complex GINS protein PSF2;GINS complex subunit 2 GINS2;PSF2;CGI-122;DC5;HSPC037 Q9Y248 ENST00000253462 K10733 1 0.76045 1.5416 0.92759 1.0481 0.95953 1.1674 VPS28 cell part;cytoplasmic part;cytosol;endosomal part;endosome membrane;intracellular organelle part;intracellular part;late endosome membrane;membrane;organelle membrane;organelle part;plasma membrane binding;protein binding establishment of localization;establishment of protein localization;protein transport;transport 6 6 6 40.3 40.3 40.3 25.425 7.1581E-130 112860000 55243000 57621000 605 IPI:IPI00007155.3 Vacuolar protein sorting-associated protein 28 homolog;ESCRT-I complex subunit VPS28;H-Vps28 VPS28 Q9UK41 ENST00000292510;ENST00000377348 K12184 1 0.53414 0.89556 0.56444 0.64979 0.64078 0.75377 CTNNB1_binding;HMG_box cell part;cytoplasm;intracellular part binding;DNA bending activity;DNA binding;nucleic acid binding;protein binding;sequence-specific DNA binding cell communication;cell morphogenesis;cell morphogenesis involved in differentiation;epithelial to mesenchymal transition;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription 6 6 4 23.1 23.1 17 44.2 3.7504E-39 556360000 295710000 260650000 606 IPI:IPI00007156.1;IPI:IPI00220456.1;IPI:IPI00164708.2;IPI:IPI00221005.1;IPI:IPI00221007.1;IPI:IPI00221009.1;IPI:IPI00221010.1;IPI:IPI00219960.2;IPI:IPI00479759.2;IPI:IPI00221004.1;IPI:IPI00221008.1;IPI:IPI00219964.3;IPI:IPI00221006.1;IPI:IPI00221011.1;IPI:IPI00335587.2;IPI:IPI00003325.3;IPI:IPI00219961.1;IPI:IPI00477092.1;IPI:IPI00478219.3;IPI:IPI00478950.2;IPI:IPI00478992.2;IPI:IPI00220455.1;IPI:IPI00385101.2;IPI:IPI00219965.1;IPI:IPI00334125.3;IPI:IPI00479370.3;IPI:IPI00477635.3;IPI:IPI00010396.1 Lymphoid enhancer-binding factor 1;T cell-specific transcription factor 1-alpha LEF1 Q9UJU2-1;Q9UJU2;Q9UJU2-3 ENST00000265165 28 0.82649 1.971 1.2815 1.1051 1.3148 1.5761 Yos1 endoplasmic reticulum membrane;Golgi apparatus;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane;membrane-bounded organelle;organelle;organelle membrane;organelle part 2 2 2 34.1 34.1 34.1 8.9687 1.44E-26 50911000 27632000 23278000 607 IPI:IPI00007166.3 Immediate early response 3-interacting protein 1 IER3IP1;HSPC039 Q9Y5U9 ENST00000256433 1 NaN 1.5376 NaN NaN 1.013 NaN Acetyltransf_1 cell part;intracellular acetyltransferase activity;acyltransferase activity;catalytic activity;N-acetyltransferase activity;N-acyltransferase activity;transferase activity;transferase activity, transferring acyl groups metabolic process 1- and 2-Methylnaphthalene degradation;Benzoate degradation via CoA ligation;Ethylbenzene degradation;Glycerophospholipid metabolism;Limonene and pinene degradation;Phenylalanine metabolism;Tyrosine metabolism 3 3 3 21.3 21.3 21.3 20.368 3.1597E-09 9711600 5464900 4246700 608 IPI:IPI00007174.5 N-acetyltransferase 5 NAT5 P61599 ENST00000334982 K00680 1 0.64306 1.5382 0.62386 0.85444 0.96612 0.85661 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;nucleic acid binding;protein binding;RNA binding anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex assembly;cellular macromolecular complex subunit organization;cellular process;ribonucleoprotein complex assembly;ribosome assembly 7 7 7 65 65 65 20.462 1.1389E-76 198050000 109860000 88192000 609 IPI:IPI00007175.3;IPI:IPI00020793.3 60S ribosome subunit biogenesis protein NIP7 homolog;KD93 NIP7;CGI-37;HSPC031;HSPC180;OK/SW-cl.76;OK/SW-cl.78 Q9Y221-1;Q9Y221;Q9Y221-2 ENST00000254940;ENST00000254941 2 0.46189 NaN 0.49256 0.62163 NaN 0.73508 GBP cell part;integral to membrane;intrinsic to membrane;membrane part binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleotide binding;pyrophosphatase activity 4 4 3 7.2 7.2 5.3 66.228 1.4305E-21 13797000 7992100 5804500 610 IPI:IPI00169267.3;IPI:IPI00007183.10;IPI:IPI00845387.1 Atlastin-2;ADP-ribosylation factor-like protein 6-interacting protein 2 ATL2;ARL6IP2 Q8NHH9-1;Q8NHH9;Q8NHH9-2;Q8NHH9-3 ENST00000332337;ENST00000378954 3 0.71441 1.474 0.71722 0.94397 0.98262 0.92322 Mito_carr integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane;mitochondrial inner membrane;mitochondrial membrane;mitochondrial nucleoid;nucleoid;organelle inner membrane;organelle membrane;organelle part adenine transmembrane transporter activity;binding;nucleobase transmembrane transporter activity;nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity;purine transmembrane transporter activity;transporter activity establishment of localization;interspecies interaction between organisms;multi-organism process;transport Calcium signaling pathway;Huntington's disease;Parkinson's disease 26 26 10 52.3 52.3 20.1 32.895 0 6068400000 3304700000 2763700000 611 IPI:IPI00007188.5 ADP/ATP translocase 2;Adenine nucleotide translocator 2;ADP,ATP carrier protein 2;Solute carrier family 25 member 5;ADP,ATP carrier protein, fibroblast isoform SLC25A5;ANT2 P05141 ENST00000317881 K05863 1 0.62567 1.0125 NaN 0.86826 0.6447 NaN Abhydro_lipase;Abhydrolase_1 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;lysosome;lytic vacuole;membrane-bounded organelle;organelle;vacuole carboxylesterase activity;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;sterol esterase activity carbohydrate metabolic process;catabolic process;cellular process;lipid catabolic process;lipid metabolic process;metabolic process;protein amino acid glycosylation;protein amino acid N-linked glycosylation;protein modification process Biosynthesis of steroids 3 3 3 6.8 6.8 6.8 45.418 1.5153E-06 7374900 3579200 3795700 612 IPI:IPI00007207.2;IPI:IPI00446007.2 Lysosomal acid lipase/cholesteryl ester hydrolase;Sterol esterase;Lipase A;Cholesteryl esterase LIPA P38571-1;P38571;P38571-2 ENST00000336233;ENST00000354621;ENST00000371829 K01052 2 0.65068 1.0372 0.57557 0.83401 0.70498 0.73548 DEAD;Helicase_C;zf-CCHC cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex ATP binding;ATP-dependent helicase activity;binding;catalytic activity;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity;RNA binding;zinc ion binding apoptosis;cell death;cellular process;metabolic process;mRNA processing;multicellular organismal development;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA processing;RNA splicing Folate biosynthesis 12 12 12 23.2 23.2 23.2 69.837 3.7942E-65 190100000 102690000 87411000 613 IPI:IPI00007208.4 Probable ATP-dependent RNA helicase DDX41;DEAD box protein 41;DEAD box protein abstrakt homolog DDX41;ABS Q9UJV9 ENST00000330503 K01529 1 0.69768 NaN NaN 0.92405 NaN NaN Carboxyl_trans cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part ATP binding;binding;catalytic activity;CoA carboxylase activity;ligase activity;ligase activity, forming carbon-carbon bonds;nucleoside binding;nucleotide binding;propionyl-CoA carboxylase activity;purine nucleoside binding;purine nucleotide binding Propanoate metabolism;Valine, leucine and isoleucine degradation 5 5 5 9.8 9.8 9.8 58.215 1.4557E-45 1517200 787340 729840 615 IPI:IPI00007247.4 Propionyl-CoA carboxylase beta chain, mitochondrial;Propanoyl-CoA:carbon dioxide ligase subunit beta PCCB P05166 ENST00000251654 K01966 1 0.95431 1.8497 1.1179 1.2136 1.2627 1.374 Phosphodiest cell part;integral to membrane;intrinsic to membrane;membrane part catalytic activity;hydrolase activity metabolic process 3 3 3 7.5 7.5 7.5 51.641 3.3261E-13 10159000 4461000 5697500 616 IPI:IPI00007249.3;IPI:IPI00419668.8 Ectonucleotide pyrophosphatase/phosphodiesterase family member 4 ENPP4;KIAA0879;NPP4 Q9Y6X5 ENST00000321037;ENST00000371401 2 0.7203 NaN 1.0104 0.91294 NaN 1.3146 cell part;cis-Golgi network;cytoplasmic part;Golgi apparatus part;intracellular organelle part;intracellular part;organelle part cellular process;ER to Golgi vesicle-mediated transport;establishment of localization;establishment of localization in cell;Golgi vesicle transport;intracellular transport;transport;vesicle-mediated transport 3 3 3 2.4 2.4 2.4 160.94 2.4101E-05 5094900 2637200 2457600 617 IPI:IPI00007253.3;IPI:IPI00216617.3 Protein TRS85 homolog KIAA1012 Q9Y2L5-1;Q9Y2L5;Q9Y2L5-2 ENST00000283351 2 NaN 1.7885 0.88461 NaN 1.1479 1.2511 Homeobox cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;sequence-specific DNA binding;transcription factor activity;transcription regulator activity;transition metal ion binding;zinc ion binding biosynthetic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription 3 3 3 4.3 4.3 4.3 92.306 2.6675E-08 23875000 12981000 10895000 618 IPI:IPI00007256.1 Zinc fingers and homeoboxes protein 2;Zinc finger and homeodomain protein 2;Alpha-fetoprotein regulator 1;Regulator of AFP ZHX2;AFR1;KIAA0854;RAF Q9Y6X8 ENST00000314393 1 NaN 1.3367 NaN NaN 0.9536 NaN BTB;zf-C2H2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transition metal ion binding;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 2 2 2 3.5 3.5 3.5 82.015 1.4738E-10 3244400 1808600 1435800 619 IPI:IPI00007273.3 Zinc finger and BTB domain-containing protein 1 ZBTB1;KIAA0997 Q9Y2K1 ENST00000394712 K10488 1 0.67581 1.74 0.57446 1.0372 1.0575 0.80347 DUF2051 binding;LRR domain binding;protein binding;protein domain specific binding biological regulation;cell communication;cell surface receptor linked signal transduction;cellular process;regulation of biological process;regulation of cellular process;signal transduction;Wnt receptor signaling pathway 8 7 7 12.9 11.2 11.2 82.17 4.1253E-141 46880000 24983000 21897000 620 IPI:IPI00007277.2;IPI:IPI00015103.2;IPI:IPI00760735.1 Leucine-rich repeat flightless-interacting protein 2;LRR FLII-interacting protein 2 LRRFIP2 Q9Y608-1;Q9Y608;Q9Y608-2 ENST00000336686;ENST00000354379 3 NaN 1.1466 NaN NaN 0.81066 NaN RNA_pol_Rpb4 cell part;DNA-directed RNA polymerase complex;DNA-directed RNA polymerase II, core complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;RNA polymerase complex binding;catalytic activity;DNA-directed RNA polymerase activity;nucleotide binding;nucleotidyltransferase activity;RNA polymerase activity;transferase activity;transferase activity, transferring phosphorus-containing groups nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile Huntington's disease;RNA polymerase 2 2 2 20.4 20.4 20.4 16.311 8.1731E-07 1729200 925120 804120 621 IPI:IPI00007283.1 DNA-directed RNA polymerase II subunit RPB4;DNA-directed RNA polymerase II subunit D;DNA-directed RNA polymerase II 16 kDa polypeptide POLR2D O15514 ENST00000272645 K03012 1 NaN 1.5203 0.71836 NaN 0.96976 0.98873 IBR cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transition metal ion binding;zinc ion binding developmental process;multicellular organismal development;multicellular organismal process 3 3 3 8.7 8.7 8.7 57.818 7.3525E-07 4651600 2523900 2127700 622 IPI:IPI00007304.1 Protein ariadne-2 homolog;Triad1 protein ARIH2;ARI2;TRIAD1;HT005 O95376 ENST00000356401 K11969 1 0.74342 1.556 0.9002 0.98431 1.0116 1.134 BCNT developmental process;multicellular organismal development;multicellular organismal process 2 2 2 10.4 10.4 10.4 33.592 5.135E-16 75110000 40045000 35065000 623 IPI:IPI00007306.1;IPI:IPI00646794.1 Craniofacial development protein 1;Bucentaur CFDP1;BCNT Q9UEE9-1;Q9UEE9;Q9UEE9-2 ENST00000283882 2 0.77415 1.2831 0.92679 0.97681 0.87545 1.1518 Tim17 integral to membrane;intrinsic to membrane;macromolecular complex;membrane-enclosed lumen;mitochondrial inner membrane presequence translocase complex;mitochondrial intermembrane space;organelle envelope lumen;organelle part;protein complex binding;P-P-bond-hydrolysis-driven transmembrane transporter activity;primary active transmembrane transporter activity;protein binding;protein transmembrane transporter activity;protein transporter activity;transporter activity cellular process;establishment of protein localization;intracellular protein transport;intracellular transport;mitochondrial transport;protein import;protein targeting;protein targeting to mitochondrion;protein transport;transport 3 3 3 16.7 16.7 16.7 21.943 4.3006E-39 85275000 44458000 40817000 624 IPI:IPI00007309.1;IPI:IPI00640747.3 Mitochondrial import inner membrane translocase subunit Tim23;Putative mitochondrial import inner membrane translocase subunit Tim23B TIMM23;TIM23;TIMM23B O14925;Q5SRD1 ENST00000260867;ENST00000374098 2 0.68453 1.2069 0.55484 0.9676 0.76585 0.81362 bZIP_Maf cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;sequence-specific DNA binding;transcription factor activity;transcription regulator activity biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 2 2 2 15.4 15.4 15.4 17.849 7.8675E-15 16562000 9377400 7184200 625 IPI:IPI00007311.1;IPI:IPI00031018.2 Transcription factor MafG;V-maf musculoaponeurotic fibrosarcoma oncogene homolog G;Transcription factor MafK;Erythroid transcription factor NF-E2 p18 subunit MAFG;MAFK O15525;O60675 ENST00000357736;ENST00000392366;ENST00000343242;ENST00000403150 K09037 2 0.81161 1.4508 0.83488 1.0989 0.9626 1.1113 DUF654 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;transcription factor activity;transcription regulator activity negative regulation of transcription from RNA polymerase II promoter;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 11 11 10 17.3 17.3 16.4 76.666 1.833E-83 268090000 140720000 127360000 626 IPI:IPI00007320.3 Transcription factor 25;Nuclear localized protein 1 TCF25;KIAA1049;NULP1;FKSG26 Q9BQ70 ENST00000263346 1 1.2056 1.6939 NaN 1.5176 1.201 NaN C1-set cell fraction;endoplasmic reticulum membrane;Golgi membrane;insoluble fraction;integral to membrane;intrinsic to membrane;macromolecular complex;membrane;membrane fraction;MHC class I peptide loading complex;microsome;organelle membrane;vesicular fraction antigen binding;binding;catalytic activity;peptide transporter activity;P-P-bond-hydrolysis-driven transmembrane transporter activity;primary active transmembrane transporter activity;protein binding;receptor binding;transporter activity antigen processing and presentation of endogenous peptide antigen;antigen processing and presentation of peptide antigen via MHC class I;immune system process;peptide metabolic process;protein complex assembly;transport Antigen processing and presentation 3 3 3 8.9 8.9 8.9 53.943 1.242E-35 17215000 8683000 8531900 627 IPI:IPI00645962.2;IPI:IPI00007327.5;IPI:IPI00217384.3 Tapasin;TAP-binding protein;TAP-associated protein;NGS-17 TAPBP;NGS17;TAPA O15533-3;O15533;O15533-1;O15533-2 ENST00000374562;ENST00000383065;ENST00000383066;ENST00000383197;ENST00000383198;ENST00000395114 K08058 3 0.69682 1.6685 0.75058 0.98419 1.0645 1.063 SAP cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleic acid binding;nucleotide binding;protein binding;pyrophosphatase activity cellular component organization;cellular process;DNA packaging;myeloid cell differentiation;organelle organization;positive regulation of myeloid leukocyte differentiation;regulation of immune system process;regulation of myeloid leukocyte differentiation 20 20 20 17.9 17.9 17.9 151.89 2.7993E-189 546310000 289420000 256880000 628 IPI:IPI00007334.1;IPI:IPI00215975.1;IPI:IPI00297991.2 Apoptotic chromatin condensation inducer in the nucleus ACIN1;ACINUS;KIAA0670 Q9UKV3-1;Q9UKV3;Q9UKV3-2;Q9UKV3-3 ENST00000262710;ENST00000397341 3 NaN 0.95872 NaN NaN 0.63723 NaN zf-C3HC4;zf-CCCH binding;cation binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transition metal ion binding;zinc ion binding 3 3 3 9.9 9.9 9.9 38.787 8.3517E-34 6084400 3058800 3025600 629 IPI:IPI00007343.1 RING finger protein 113A;Zinc finger protein 183 RNF113A;RNF113;ZNF183 O15541 ENST00000371442 1 0.8898 1.4438 0.85494 1.1697 1.0218 1.1056 Pro_isomerase cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;catalytic activity;cis-trans isomerase activity;cyclosporin A binding;drug binding;isomerase activity;peptide binding;peptidyl-prolyl cis-trans isomerase activity mRNA processing;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein complex assembly;protein folding;protein import into nucleus;protein targeting;RNA processing;snRNP protein import into nucleus 11 11 11 64.4 64.4 64.4 19.208 1.2554E-127 312010000 164740000 147270000 630 IPI:IPI00007346.1 Peptidyl-prolyl cis-trans isomerase H;U-snRNP-associated cyclophilin SnuCyp-20;Small nuclear ribonucleoprotein particle-specific cyclophilin H PPIH;CYP20;CYPH O43447 ENST00000304979 K09567 1 0.75334 1.4854 0.845 0.94582 1.0123 1.1045 COG5 cell part;cytoplasmic part;cytosol;Golgi apparatus part;Golgi membrane;Golgi transport complex;intracellular organelle part;intracellular part;macromolecular complex;membrane;organelle membrane;organelle part;protein complex binding;protein binding cellular process;establishment of localization;establishment of protein localization;Golgi vesicle transport;intracellular transport;intra-Golgi vesicle-mediated transport;protein transport;transport;vesicle-mediated transport 11 11 11 15 15 15 94.876 2.6041E-40 89982000 47309000 42674000 631 IPI:IPI00377050.2;IPI:IPI00007347.4;IPI:IPI00885051.1 Conserved oligomeric Golgi complex subunit 5;Component of oligomeric Golgi complex 5;13S Golgi transport complex 90 kDa subunit;Golgi transport complex 1 COG5;GOLTC1;GTC90 Q9UP83-2;Q9UP83;Q9UP83-1;Q9UP83-3 ENST00000297135;ENST00000347053 3 0.75246 1.6348 0.78607 1.0188 1.1426 1.0188 IBN_N cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;organelle part;pore complex;protein complex binding;enzyme binding;GTPase binding;protein binding;protein transporter activity;Ran GTPase binding;Ras GTPase binding;small GTPase binding;substrate-specific transporter activity;transporter activity anatomical structure formation;cell communication;cellular component assembly;cellular component organization;cellular process;protein complex assembly;protein import into nucleus, docking;signal transduction 11 10 10 12.1 11.1 11.1 119.94 4.1741E-157 186780000 94493000 92287000 633 IPI:IPI00007401.2 Importin-8;Ran-binding protein 8 IPO8;RANBP8 O15397 ENST00000256079 1 0.65502 1.483 0.7058 0.85962 0.95952 0.90496 IBN_N cell fraction;cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;organelle part;pore complex;protein complex;soluble fraction binding;enzyme binding;enzyme regulator activity;GTPase regulator activity;protein binding;protein transporter activity;Ran GTPase binding;Ras GTPase binding;small GTPase regulator activity;substrate-specific transporter activity;transporter activity anatomical structure formation;cell communication;cellular component assembly;cellular component organization;cellular process;protein complex assembly;protein import into nucleus, docking;signal transduction 13 13 12 13.2 13.2 12.2 119.52 0 435260000 237600000 197660000 634 IPI:IPI00007402.3 Importin-7;Ran-binding protein 7 IPO7;RANBP7 O95373 ENST00000379719 1 0.49995 1.5081 0.32021 0.61622 1.0281 0.46661 ThiF cell part;cytoplasm;intracellular part binding;catalytic activity;identical protein binding;protein binding;protein dimerization activity;protein homodimerization activity;small protein activating enzyme activity;ubiquitin activating enzyme activity autophagy;catabolic process;cellular process;macromolecule catabolic process;membrane fusion;metabolic process;positive regulation of metabolic process;protein amino acid lipidation;protein modification process;proteolysis;transport 3 3 3 6.7 6.7 6.7 77.959 9.055E-45 8851500 5481200 3370400 635 IPI:IPI00007404.1;IPI:IPI00479911.3 Autophagy-related protein 7;APG7-like;Ubiquitin-activating enzyme E1-like protein ATG7;APG7L O95352-1;O95352;O95352-2 ENST00000354449;ENST00000354956 2 1.1616 1.5035 NaN 1.5323 1.0195 NaN centrosome;cytoplasmic part;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;microtubule organizing center;non-membrane-bounded organelle;organelle;organelle part binding;enzyme binding;phosphatase binding;protein binding;protein kinase A binding;protein phosphatase 1 binding;protein phosphatase binding biological regulation;cell communication;cellular process;intracellular signaling cascade;protein kinase cascade;regulation of biological process;regulation of cellular process;signal transduction 6 6 6 4 4 4 210.51 6.0948E-19 1307800 692580 615190 636 IPI:IPI00007411.1 A-kinase anchor protein 11;Protein kinase A-anchoring protein 11;A kinase anchor protein 220 kDa AKAP11;AKAP220;KIAA0629 Q9UKA4 ENST00000025301 1 0.71031 1.6521 0.73322 0.96612 1.0015 1.0103 LRR_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding 12 12 9 35.5 35.5 27.9 28.787 3.0518E-175 3165100000 1663100000 1502000000 637 IPI:IPI00007423.1;IPI:IPI00759824.2 Acidic leucine-rich nuclear phosphoprotein 32 family member B;Acidic protein rich in leucines;PHAPI2;Silver-stainable protein SSP29 ANP32B;APRIL;PHAPI2 Q92688-1;Q92688;Q92688-2 ENST00000339399 2 1.0575 2.1829 1.0027 1.3185 1.4632 1.2774 PRA1 cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part binding;protein binding acidic amino acid transport;amine transport;amino acid transport;carboxylic acid transport;cellular process;establishment of localization;L-glutamate transport;organic acid transport;transmembrane transport;transport 3 3 3 16.5 16.5 16.5 21.614 1.0742E-46 120350000 59301000 61054000 638 IPI:IPI00007426.1 PRA1 family protein 3;ADP-ribosylation factor-like protein 6-interacting protein 5;Glutamate transporter EAAC1-interacting protein;GTRAP3-18;Prenylated Rab acceptor protein 2;Protein JWa;Dermal papilla-derived protein 11;JM5;Putative MAPK-activating protein PM27;Cytoskeleton-related vitamin A-responsive protein ARL6IP5;DERP11;JWA;PRA2;PRAF3;HSPC127 O75915 ENST00000273258 1 0.78163 1.6008 0.82967 0.99824 1.1249 1.046 OSCP macromolecular complex;membrane;mitochondrial proton-transporting ATP synthase complex;organelle part;plasma membrane;protein complex;proton-transporting two-sector ATPase complex;proton-transporting two-sector ATPase complex, catalytic domain binding;catalytic activity;cation transmembrane transporter activity;drug binding;hydrogen ion transmembrane transporter activity;ion transmembrane transporter activity;monovalent inorganic cation transmembrane transporter activity;transporter activity ATP catabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide catabolic process;purine nucleotide metabolic process Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 12 12 12 65.7 65.7 65.7 23.277 0 2214700000 1187200000 1027500000 639 IPI:IPI00007611.1 ATP synthase subunit O, mitochondrial;Oligomycin sensitivity conferral protein ATP5O;ATPO P48047 ENST00000290299 K02137 1 0.46337 0.96635 0.47333 0.61754 0.65683 0.6221 Pkinase cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;kinase activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cell communication;I-kappaB kinase/NF-kappaB cascade;intracellular signaling cascade;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein kinase cascade;protein modification process;signal transduction Apoptosis;Toll-like receptor signaling pathway 17 17 17 37.2 37.2 37.2 51.529 1.1514E-109 41571000 19933000 21638000 640 IPI:IPI00007641.2 Interleukin-1 receptor-associated kinase 4;NY-REN-64 antigen IRAK4 Q9NWZ3 ENST00000356669 K04733 1 0.74175 1.5668 0.88621 1.0006 1.014 1.1991 XRCC4 cell part;cytoplasmic part;cytosol;DNA ligase IV complex;DNA-dependent protein kinase-DNA ligase 4 complex;intracellular organelle part;intracellular part;macromolecular complex;nonhomologous end joining complex;nuclear part;organelle part;protein complex binding;DNA binding;nucleic acid binding;protein binding;protein C-terminus binding DNA ligation;DNA metabolic process;DNA recombination;DNA repair;double-strand break repair;double-strand break repair via nonhomologous end joining;non-recombinational repair;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Non-homologous end-joining 5 5 5 15.8 15.8 15.8 38.286 3.2442E-10 27272000 14738000 12534000 641 IPI:IPI00007672.1;IPI:IPI00019678.1;IPI:IPI00401064.1 DNA repair protein XRCC4;X-ray repair cross-complementing protein 4 XRCC4 Q13426-1;Q13426;Q13426-2;Q13426-3 ENST00000282268;ENST00000338635;ENST00000396027 K10886 3 0.75117 1.3855 0.71593 0.9802 0.88116 0.90956 CHCH cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle 3 3 3 15.2 15.2 15.2 15.512 6.042E-109 485090000 250400000 234690000 642 IPI:IPI00007673.4;IPI:IPI00401259.1 Coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial;HCV NS2 trans-regulated protein;Aging-associated gene 10 protein CHCHD2;C7orf17;AAG10 Q9Y6H1 ENST00000359914;ENST00000395422 2 0.73973 1.5024 0.7198 0.99278 0.98095 0.95379 DLIC cell part;cytoskeletal part;dynein complex;intracellular organelle part;intracellular part;macromolecular complex;microtubule;microtubule associated complex;organelle part;protein complex ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;motor activity;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity 21 21 20 43.4 43.4 40.9 56.578 2.2613E-179 658060000 357290000 300770000 643 IPI:IPI00007675.6 Cytoplasmic dynein 1 light intermediate chain 1;Dynein light intermediate chain 1, cytosolic DYNC1LI1;DNCLI1 Q9Y6G9 ENST00000273130 K10416 1 0.8187 1.7353 0.74865 1.1758 1.2149 1.1513 adh_short cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part catalytic activity;estradiol 17-beta-dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;steroid dehydrogenase activity biosynthetic process;cellular biosynthetic process;cellular metabolic process;cellular process;lipid biosynthetic process;lipid metabolic process;metabolic process;primary metabolic process;steroid biosynthetic process;steroid metabolic process Androgen and estrogen metabolism;Biosynthesis of unsaturated fatty acids 7 7 7 28.8 28.8 28.8 34.324 4.8374E-76 144150000 73713000 70434000 644 IPI:IPI00007676.3 Estradiol 17-beta-dehydrogenase 12;17-beta-hydroxysteroid dehydrogenase 12;3-ketoacyl-CoA reductase HSD17B12 Q53GQ0 ENST00000278353 K00044;K10251 1 0.95197 1.8077 0.96454 1.2308 1.2288 1.1915 ATP-synt_ab;ATP-synt_ab_C;ATP-synt_ab_N integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;macromolecular complex;protein complex;proton-transporting two-sector ATPase complex, catalytic domain;proton-transporting V-type ATPase, V1 domain ATP binding;binding;catalytic activity;cation transmembrane transporter activity;ion transmembrane transporter activity;nucleoside binding;nucleotide binding;purine nucleoside binding;transporter activity ATP biosynthetic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;transport Epithelial cell signaling in Helicobacter pylori infection;Oxidative phosphorylation;Vibrio cholerae infection 26 26 26 50.4 50.4 50.4 68.303 0 1571400000 826190000 745210000 645 IPI:IPI00007682.2 V-type proton ATPase catalytic subunit A;Vacuolar proton pump subunit alpha;V-ATPase 69 kDa subunit;Vacuolar ATPase isoform VA68 ATP6V1A;ATP6A1;ATP6V1A1;VPP2 P38606 ENST00000273398 K02145 1 0.76532 1.2972 0.72327 0.98952 0.87392 0.96753 Sybindin cell projection;clathrin-coated vesicle;coated vesicle;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;dendrite;endoplasmic reticulum;Golgi stack;membrane-bounded vesicle;neuron projection;organelle;synaptic vesicle;vesicle binding;protein binding cell projection organization;cellular component organization;cellular process;dendrite development;developmental process;ER to Golgi vesicle-mediated transport;intracellular transport;neuron projection development;transport;vesicle-mediated transport 8 8 8 38.4 38.4 38.4 24.34 7.0317E-80 86351000 45397000 40954000 646 IPI:IPI00007691.1 Trafficking protein particle complex subunit 4;Synbindin;TRS23 homolog;Hematopoietic stem/progenitor cell protein 172 TRAPPC4;SBDN;CGI-104;HSPC172;PTD009 Q9Y296 ENST00000359005 1 1.0019 1.8169 1.005 1.2594 1.168 1.2339 Abhydrolase_1 binding;carboxylesterase activity;catalytic activity;enzyme inhibitor activity;hydrolase activity;hydrolase activity, acting on ester bonds;phosphoprotein phosphatase inhibitor activity;protein binding;protein phosphatase type 2A regulator activity biopolymer metabolic process;cellular biopolymer metabolic process;cellular process;macromolecule metabolic process;metabolic process;protein amino acid dealkylation;protein amino acid demethylation;protein metabolic process;protein modification process 2,4-Dichlorobenzoate degradation;Alkaloid biosynthesis II 14 14 14 42.2 42.2 42.2 42.315 6.5861E-80 377760000 195930000 181830000 647 IPI:IPI00007694.5;IPI:IPI00412156.3;IPI:IPI00921280.1 Protein phosphatase methylesterase 1 PPME1;PME1;PP2593;PRO0750 Q9Y570-1;Q9Y570;Q9Y570-2 ENST00000328257;ENST00000398456 K01066 3 0.64836 NaN 0.71358 0.88279 NaN 0.91042 HSP70 cell part;cell surface;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cell cycle phase;cell cycle process;cellular process;developmental process;germ cell development;male meiosis;meiosis;response to biotic stimulus;response to organic substance;response to stress;response to unfolded protein;spermatid development Antigen processing and presentation;MAPK signaling pathway 14 1 1 17.8 1.9 1.9 70.02 0 229470000 128240000 101230000 648 IPI:IPI00007702.1 Heat shock-related 70 kDa protein 2 HSPA2 P54652 ENST00000247207;ENST00000394709 K03283 1 0.64565 1.0721 0.62702 0.86281 0.68272 0.81797 NUC129 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part 5 5 5 20.2 20.2 20.2 29.426 7.3946E-49 181800000 96852000 84945000 649 IPI:IPI00007729.1;IPI:IPI00607836.1 Nucleolar protein 7;Nucleolar protein of 27 kDa NOL7;C6orf90;NOP27 Q9UMY1-1;Q9UMY1;Q9UMY1-2 ENST00000259969 2 0.82627 1.794 1.0203 1.0713 1.2217 1.2998 Erg28 cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;endoplasmic reticulum membrane;integral to membrane;intrinsic to membrane;membrane;membrane-bounded organelle;membrane-bounded vesicle;organelle;organelle membrane;transport vesicle;vesicle alcohol metabolic process;biosynthetic process;cellular process;lipid biosynthetic process;lipid metabolic process;metabolic process;steroid biosynthetic process;steroid metabolic process;sterol biosynthetic process;sterol metabolic process 2 2 2 13.6 13.6 13.6 15.864 1.3185E-14 60541000 29068000 31474000 650 IPI:IPI00007730.1 Probable ergosterol biosynthetic protein 28 C14orf1;AD-011;HSPC288;x0006 Q9UKR5 ENST00000256319 1 0.61983 1.7511 0.70568 0.87316 1.1357 0.9997 BAG binding;protein binding apoptosis;biopolymer metabolic process;cell death;cellular biopolymer metabolic process;cellular metabolic process;cellular process;death;macromolecule metabolic process;metabolic process;programmed cell death;protein folding;protein metabolic process 4 4 4 9.2 9.2 9.2 56.026 1.0515E-33 22923000 12933000 9990200 651 IPI:IPI00556027.1;IPI:IPI00007731.1 BAG family molecular chaperone regulator 5;Bcl-2-associated athanogene 5 BAG5;KIAA0873 Q9UL15-2;Q9UL15;Q9UL15-1 ENST00000299204;ENST00000337322 K09559 2 0.60662 NaN NaN 0.85088 NaN NaN DUF1785;PAZ;Piwi cell part;cytoplasmic mRNA processing body;cytoplasmic part;intracellular part;macromolecular complex;ribonucleoprotein complex binding;nucleic acid binding;protein binding;RNA binding mRNA catabolic process;nuclear-transcribed mRNA catabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;regulation of translation;RNA catabolic process;transcription 4 1 1 6.1 1.6 1.6 97.213 1.9073E-11 269960 161710 108250 652 IPI:IPI00007736.5;IPI:IPI00030602.6 Protein argonaute-1;Argonaute1;Eukaryotic translation initiation factor 2C 1;Putative RNA-binding protein Q99;Protein argonaute-4;Argonaute4;Eukaryotic translation initiation factor 2C 4 EIF2C1;AGO1;EIF2C4;AGO4;KIAA1567 Q9UL18;Q9HCK5 ENST00000373204;ENST00000373210 K11593 2 0.76518 1.3499 0.76214 0.99541 0.90493 0.96333 Tubulin;Tubulin_C cell part;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;microtubule;organelle part;protein complex binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity;structural molecule activity anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;microtubule-based movement;microtubule-based process;protein complex assembly Gap junction 26 6 2 64.7 16.5 4.2 49.924 0 8712500000 4581100000 4131400000 653 IPI:IPI00007750.1 Tubulin alpha-4A chain;Tubulin alpha-1 chain;Alpha-tubulin 1;Testis-specific alpha-tubulin;Tubulin H2-alpha TUBA4A;TUBA1 P68366 ENST00000248437 K07374 1 0.76623 1.4349 0.75374 0.9933 0.95459 0.96441 Tubulin;Tubulin_C cell part;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;microtubule;organelle part;protein complex binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity;receptor binding;structural molecule activity cell killing;cell motion;immune effector process;immune system process;induction of apoptosis;leukocyte mediated cytotoxicity;leukocyte mediated immunity;lymphocyte mediated immunity;natural killer cell mediated immunity;protein complex assembly Gap junction 33 33 2 70.1 70.1 3.6 49.83 0 53403000000 28130000000 25273000000 654 IPI:IPI00007752.1;IPI:IPI00174849.4;IPI:IPI00018511.1;IPI:IPI00739915.3;IPI:IPI00006510.1 Tubulin beta-2C chain;Tubulin beta-2 chain TUBB2C P68371 ENST00000340384 K07375 5 0.88541 1.9585 0.90296 1.1115 1.2656 1.2299 Ras cytoplasmic vesicle membrane;early endosome membrane;endoplasmic reticulum membrane;endosome membrane;Golgi apparatus part;Golgi membrane;intracellular part;membrane;membrane part;organelle membrane;organelle part;vesicle membrane binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cell communication;cellular process;establishment of protein localization;intracellular signaling cascade;protein transport;regulation of biological process;signal transduction;small GTPase mediated signal transduction;transport 9 9 9 33.8 33.8 33.8 24.347 1.3056E-159 604290000 298860000 305420000 655 IPI:IPI00007755.3 Ras-related protein Rab-21 RAB21;KIAA0118 Q9UL25 ENST00000261263 K07890 1 NaN 2.4818 NaN NaN 1.5494 NaN Ras cytoplasmic part;early endosome;endosomal part;endosome;endosome membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;organelle;organelle membrane;organelle part;plasma membrane binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity cell communication;cellular process;endocytosis;endosome organization;intracellular signaling cascade;membrane invagination;organelle organization;protein transport;signal transduction;small GTPase mediated signal transduction;transport 3 3 3 27.8 27.8 27.8 21.855 2.6396E-76 4732900 2664900 2068000 656 IPI:IPI00007756.1 Ras-related protein Rab-22A RAB22A;RAB22 Q9UL26 ENST00000244040 K07891 1 0.65267 1.315 0.62552 0.87192 0.83008 0.81002 zf-C2H2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 6 6 6 17.3 17.3 17.3 59.573 1.0385E-33 145860000 77999000 67861000 657 IPI:IPI00007757.2;IPI:IPI00218656.2 Zinc finger protein Helios;Ikaros family zinc finger protein 2 IKZF2;HELIOS;ZNFN1A2 Q9UKS7-1;Q9UKS7;Q9UKS7-2 ENST00000342002;ENST00000374319 K09220 2 0.58599 NaN 0.73395 0.82969 NaN 1.0161 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 4 4 4 32 32 32 19.916 1.3072E-99 949220000 480720000 468500000 658 IPI:IPI00384857.3;IPI:IPI00007764.4;IPI:IPI00447316.1 Hematological and neurological expressed 1 protein;Androgen-regulated protein 2 HN1;ARM2 Q9UK76-2;Q9UK76;Q9UK76-1;Q9UK76-3 ENST00000304834;ENST00000356033;ENST00000392573;ENST00000409753 3 1.0241 1.8465 0.9996 1.334 1.2541 1.3313 HSP70 cell part;cell surface;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial nucleoid;mitochondrial part;nucleoid;organelle part adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding anti-apoptosis;cellular biopolymer metabolic process;cellular process;metabolic process;negative regulation of apoptosis;protein folding;protein metabolic process;regulation of apoptosis;regulation of cell death;regulation of programmed cell death 41 41 41 58 58 58 73.68 0 12725000000 6223000000 6502000000 659 IPI:IPI00007765.5 Stress-70 protein, mitochondrial;75 kDa glucose-regulated protein;GRP 75;Heat shock 70 kDa protein 9;Peptide-binding protein 74;Mortalin HSPA9;GRP75;HSPA9B P38646 ENST00000297185 K04043 1 0.66616 1.3803 0.66033 0.8843 0.90308 0.89013 Lipocalin cell part;cytoplasm;intracellular part binding;carboxylic acid binding;fatty acid binding;lipid binding;monocarboxylic acid binding;protein binding;transporter activity anatomical structure development;developmental process;epidermis development;establishment of localization;lipid metabolic process;metabolic process;primary metabolic process;tissue development;transport PPAR signaling pathway 15 15 15 91.9 91.9 91.9 15.164 0 4540300000 2909900000 1630400000 661 IPI:IPI00007797.3;IPI:IPI00869087.2 Fatty acid-binding protein, epidermal;E-FABP;Fatty acid-binding protein 5;Psoriasis-associated fatty acid-binding protein homolog FABP5 Q01469 ENST00000297258 K08754 2 0.1762 0.40071 NaN 0.23401 0.25568 NaN Pkinase cell part;cyclin-dependent protein kinase holoenzyme complex;cytoplasmic part;cytosol;intracellular part;macromolecular complex;protein complex ATP binding;binding;catalytic activity;cyclin-dependent protein kinase activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding cellular process;G1/S transition of mitotic cell cycle;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;positive regulation of cell proliferation;protein amino acid phosphorylation;protein modification process Bladder cancer;Cell cycle;Chronic myeloid leukemia;Glioma;Melanoma;Non-small cell lung cancer;p53 signaling pathway;Pancreatic cancer;Pathways in cancer;Small cell lung cancer;T cell receptor signaling pathway;Tight junction 3 2 2 11.9 9.2 9.2 33.729 3.0395E-10 20488000 11799000 8689500 662 IPI:IPI00007811.1 Cell division protein kinase 4;Cyclin-dependent kinase 4;PSK-J3 CDK4 P11802 ENST00000257904 K02089 1 0.97469 1.6674 0.95216 1.2485 1.1483 1.219 ATP-synt_ab;ATP-synt_ab_C;ATP-synt_ab_N cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;endomembrane system;macromolecular complex;melanosome;membrane-bounded vesicle;proton-transporting two-sector ATPase complex, catalytic domain;proton-transporting V-type ATPase, V1 domain;vesicle catalytic activity;cation transmembrane transporter activity;hydrogen ion transmembrane transporter activity;ion transmembrane transporter activity;monovalent inorganic cation transmembrane transporter activity;transporter activity ATP biosynthetic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;transport Epithelial cell signaling in Helicobacter pylori infection;Oxidative phosphorylation;Vibrio cholerae infection 23 23 23 55.6 55.6 55.6 56.5 0 1390600000 704630000 685950000 663 IPI:IPI00007812.1;IPI:IPI00304911.4 V-type proton ATPase subunit B, brain isoform;Vacuolar proton pump subunit B 2;Endomembrane proton pump 58 kDa subunit;HO57 ATP6V1B2;ATP6B2;VPP3 P21281 ENST00000276390 K02147 2 0.86042 1.8505 0.97009 1.1807 1.1728 1.2966 V-ATPase_C cell part;macromolecular complex;membrane part;protein complex;proton-transporting two-sector ATPase complex, catalytic domain;proton-transporting V-type ATPase, V1 domain binding;catalytic activity;cation transmembrane transporter activity;hydrogen ion transmembrane transporter activity;ion transmembrane transporter activity;monovalent inorganic cation transmembrane transporter activity;protein binding;transporter activity ATP biosynthetic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;transport Epithelial cell signaling in Helicobacter pylori infection;Oxidative phosphorylation;Vibrio cholerae infection 13 13 13 37.7 37.7 37.7 43.941 2.2116E-206 217040000 113300000 103740000 664 IPI:IPI00007814.3;IPI:IPI00719217.2;IPI:IPI00302644.2 V-type proton ATPase subunit C 1;Vacuolar proton pump subunit C 1 ATP6V1C1;ATP6C;ATP6D;VATC P21283 ENST00000395862 K02148 3 0.71802 1.3436 0.68445 0.95862 0.86046 0.90707 Lactamase_B;RMMBL cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;catalytic activity;cation binding;endonuclease activity;hydrolase activity;hydrolase activity, acting on ester bonds;ion binding;metal ion binding;nuclease activity;nucleic acid binding;RNA binding;transition metal ion binding;zinc ion binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 14 14 14 24 24 24 77.485 1.5392E-71 393120000 204810000 188310000 665 IPI:IPI00007818.3 Cleavage and polyadenylation specificity factor subunit 3;Cleavage and polyadenylation specificity factor 73 kDa subunit;mRNA 3'-end-processing endonuclease CPSF-73 CPSF3;CPSF73 Q9UKF6 ENST00000238112 1 0.86348 1.5619 NaN 1.1401 1.0376 NaN IQ;Myosin_head;Myosin_N;Myosin_tail_1 adherens junction;cell junction;cell-substrate adherens junction;cell-substrate junction;focal adhesion;macromolecular complex;muscle myosin complex;myosin complex;myosin filament;myosin II complex;nucleolus;organelle;striated muscle thick filament actin binding;ATP binding;binding;calmodulin binding;catalytic activity;cytoskeletal protein binding;microfilament motor activity;motor activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;structural molecule activity actin filament-based movement;actin filament-based process;cellular process;cytoskeleton-dependent intracellular transport;muscle contraction;muscle filament sliding;muscle system process;striated muscle contraction;system process;transport Tight junction 4 2 2 1.9 1.1 1.1 223.04 4.7709E-05 82862000 46435000 36427000 666 IPI:IPI00007856.1;IPI:IPI00025879.2;IPI:IPI00001753.2;IPI:IPI00007858.1;IPI:IPI00025880.2 Myosin-2;Myosin heavy chain 2;Myosin heavy chain 2a;Myosin heavy chain IIa;Myosin heavy chain, skeletal muscle, adult 2;Myosin-1;Myosin heavy chain 1;Myosin heavy chain 2x;Myosin heavy chain, skeletal muscle, adult 1;Myosin heavy chain IIx/d;Myosin-4;Myosin heavy chain 4;Myosin heavy chain 2b;Myosin heavy chain IIb;Myosin heavy chain, skeletal muscle, fetal;Myosin-13;Myosin heavy chain 13;Myosin heavy chain, skeletal muscle, extraocular;Myosin-7;Myosin heavy chain 7;Myosin heavy chain, cardiac muscle beta isoform;Myosin heavy chain slow isoform MYH2;MYHSA2;MYH1;MYH4;MYH13;MYH7;MYHCB Q9UKX2;P12882;Q9Y623;Q9UKX3;P12883 ENST00000245503;ENST00000226207;ENST00000255381;ENST00000252172;ENST00000355349;ENST00000361594;ENST00000397183 K10352 5 NaN 1.5316 NaN NaN 1.0699 NaN PH;RhoGAP;SH3_1 adherens junction;cell junction;cell-substrate adherens junction;cell-substrate junction;cytoplasm;cytoskeleton;focal adhesion;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle binding;enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;protein binding;Ras GTPase activator activity;Rho GTPase activator activity;small GTPase regulator activity actin cytoskeleton organization;actin filament-based process;cell communication;cellular component organization;cellular process;cytoskeleton organization;developmental process;nervous system development;organelle organization;signal transduction 2 2 2 3.9 3.9 3.9 92.234 1.2001E-06 370650 220070 150590 667 IPI:IPI00007913.1;IPI:IPI00216360.1 Rho GTPase-activating protein 26;Rho-type GTPase-activating protein 26;Oligophrenin-1-like protein;GTPase regulator associated with focal adhesion kinase ARHGAP26;GRAF;KIAA0621;OPHN1L Q9UNA1-1;Q9UNA1;Q9UNA1-2 ENST00000274498 2 0.82448 1.6716 1.7903 1.0041 1.1714 2.14 Nuc_deoxyrib_tr cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle cell proliferation;cellular process 4 4 4 23 23 23 19.108 3.5245E-49 371980000 169060000 202920000 668 IPI:IPI00007926.1 Deoxyribonucleoside 5'-monophosphate N-glycosidase;c-Myc-responsive protein Rcl RCL;C6orf108 O43598 ENST00000230431 1 0.73096 1.4123 0.74869 0.9865 0.91337 0.99856 SMC_hinge;SMC_N chromosome;condensin complex;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear chromosome;organelle;organelle part;protein complex adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cell cycle process;cell division;cellular component organization;cellular process;chromosome condensation;chromosome organization;DNA packaging;mitotic chromosome condensation;organelle organization Cell cycle - yeast 45 45 45 39.5 39.5 39.5 135.65 0 3036600000 1621400000 1415100000 669 IPI:IPI00007927.4;IPI:IPI00232806.4 Structural maintenance of chromosomes protein 2;Chromosome-associated protein E;XCAP-E homolog SMC2;CAPE;SMC2L1;PRO0324 O95347-1;O95347;O95347-2 ENST00000286398;ENST00000303219;ENST00000374787;ENST00000374793 K06674 2 0.67662 1.2386 0.69666 0.87237 0.82199 0.8981 Mov34;PRO8NT;PROCN;PROCT;RRM_4;U5_2-snRNA_bdg;U6-snRNA_bdg cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part;ribonucleoprotein complex;small nuclear ribonucleoprotein complex;U5 snRNP binding;catalytic activity;nucleic acid binding;protein binding;RNA binding;RNA splicing factor activity, transesterification mechanism nuclear mRNA splicing, via spliceosome;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile;system process 85 85 85 42.8 42.8 42.8 273.6 0 3965800000 2184400000 1781400000 670 IPI:IPI00007928.4 Pre-mRNA-processing-splicing factor 8;Splicing factor Prp8;PRP8 homolog;220 kDa U5 snRNP-specific protein;p220 PRPF8;PRPC8 Q6P2Q9 ENST00000304992 1 0.80095 1.5711 0.89778 1.0781 1.0393 1.1925 LIM;PDZ actin cytoskeleton;cell fraction;cell part;cytoplasmic part;cytoskeleton;cytosol;insoluble fraction;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane fraction;non-membrane-bounded organelle;organelle actin binding;actinin binding;binding;cation binding;cytoskeletal protein binding;enzyme binding;ion binding;kinase binding;metal ion binding;protein binding;protein kinase binding;protein kinase C binding;transition metal ion binding;zinc ion binding 11 11 11 20.6 20.6 20.6 64.001 2.9404E-58 133070000 68631000 64444000 671 IPI:IPI00007935.5 PDZ and LIM domain protein 5;Enigma homolog;Enigma-like PDZ and LIM domains protein PDLIM5;ENH;L9 Q96HC4 ENST00000317968 1 0.67674 1.1413 0.60594 0.84431 0.80397 0.79681 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cyclin-dependent protein kinase inhibitor activity;cyclin-dependent protein kinase regulator activity;enzyme inhibitor activity;nucleic acid binding;protein binding;protein kinase inhibitor activity;RNA binding;snRNA binding negative regulation of transcription from RNA polymerase II promoter;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of cyclin-dependent protein kinase activity;regulation of transcription, DNA-dependent;transcription 4 4 4 15 15 15 40.623 2.0145E-108 49009000 25514000 23495000 672 IPI:IPI00007941.4 Protein HEXIM1;Hexamethylene bis-acetamide-inducible protein 1;Estrogen down-regulated gene 1 protein;Cardiac lineage protein 1;Menage a quatre protein 1 HEXIM1;CLP1;EDG1;HIS1;MAQ1 O94992 ENST00000332499 1 0.89612 1.7123 0.85912 1.2407 1.0702 1.1491 Mov34 cell part;cytoplasmic part;early endosome;endosome;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;cation binding;hydrolase activity;hydrolase activity, acting on ester bonds;ion binding;metallopeptidase activity;peptidase activity;protein binding;thiolester hydrolase activity;ubiquitin thiolesterase activity;zinc ion binding catabolic process;cell communication;cellular process;intracellular signaling cascade;JAK-STAT cascade;macromolecule catabolic process;metabolic process;positive regulation of cell proliferation;protein kinase cascade;proteolysis;signal transduction 10 10 10 28.5 28.5 28.5 48.076 9.6223E-117 208740000 111500000 97237000 673 IPI:IPI00007943.1 STAM-binding protein;Associated molecule with the SH3 domain of STAM STAMBP;AMSH O95630 ENST00000339566;ENST00000394070;ENST00000394073;ENST00000409707 K11866 1 0.62505 1.4126 0.64098 0.79984 0.95212 0.8384 HTH_9;RNA_pol_Rpc82 cell part;DNA-directed RNA polymerase complex;DNA-directed RNA polymerase III complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;RNA polymerase complex binding;catalytic activity;DNA binding;DNA-directed RNA polymerase activity;nucleic acid binding;nucleotidyltransferase activity;RNA polymerase activity;transferase activity;transferase activity, transferring phosphorus-containing groups metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase III promoter;regulation of transcription, DNA-dependent;transcription RNA polymerase 9 9 9 18.4 18.4 18.4 60.611 8.8335E-100 33432000 17839000 15594000 675 IPI:IPI00007948.2 DNA-directed RNA polymerase III subunit RPC3;DNA-directed RNA polymerase III subunit C;DNA-directed III 62 kDa polypeptide;RPC62 POLR3C Q9BUI4 ENST00000334163 K03023 1 NaN 0.88599 NaN NaN 0.61669 NaN DUF1546;TAF cell part;chromatin remodeling complex;histone acetyltransferase complex;histone deacetylase complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;STAGA complex binding;DNA binding;nucleic acid binding;protein binding;RNA polymerase II transcription factor activity;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding chromatin organization;chromatin remodeling;organelle organization;protein amino acid acetylation;protein modification process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription initiation Basal transcription factors 3 3 3 7.2 7.2 7.2 67.814 4.0527E-16 780650 363730 416920 676 IPI:IPI00007957.1 TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L;PCAF-associated factor 65 alpha TAF6L;PAF65A Q9Y6J9 ENST00000294168 K03131 1 0.81073 1.492 1.5485 1.0735 0.94203 1.9772 LIM;PDZ cell part;cell surface;cytoplasm;cytoskeleton;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding 3 3 3 10.7 10.7 10.7 39.181 3.2834E-05 8930300 3792100 5138200 679 IPI:IPI00007983.2;IPI:IPI00396593.5;IPI:IPI00386717.1;IPI:IPI00383278.4 PDZ and LIM domain protein 2;PDZ-LIM protein mystique PDLIM2;PP6345 Q96JY6-3;Q96JY6;Q96JY6-1;Q96JY6-4;Q96JY6-2 ENST00000265810;ENST00000308354;ENST00000339162;ENST00000381194;ENST00000397760;ENST00000397761;ENST00000409417 4 0.78624 NaN NaN 0.96499 NaN NaN AMP-binding cell fraction;endoplasmic reticulum membrane;insoluble fraction;integral to membrane;intrinsic to membrane;membrane;membrane fraction;microbody membrane;microsome;mitochondrial outer membrane;organelle membrane;outer membrane;peroxisomal membrane ATP binding;binding;catalytic activity;fatty-acid ligase activity;ligase activity;ligase activity, forming carbon-sulfur bonds;long-chain-fatty-acid-CoA ligase activity;magnesium ion binding;nucleoside binding;nucleotide binding;purine nucleoside binding carboxylic acid metabolic process;cellular ketone metabolic process;cellular process;fatty acid metabolic process;lipid metabolic process;metabolic process;monocarboxylic acid metabolic process;organic acid metabolic process;oxoacid metabolic process Adipocytokine signaling pathway;Fatty acid metabolism;PPAR signaling pathway 2 1 1 3.4 1.9 1.9 82.262 2.7529E-23 3851300 2174100 1677100 681 IPI:IPI00401990.2;IPI:IPI00008037.1;IPI:IPI00854706.1 Long-chain-fatty-acid--CoA ligase 5;Long-chain acyl-CoA synthetase 5 ACSL5;ACS5;FACL5;UNQ633/PRO1250 Q9ULC5-3;Q9ULC5;Q9ULC5-1;Q9ULC5-4 ENST00000354273;ENST00000354655;ENST00000356116;ENST00000369410;ENST00000393081 K01897 3 0.80887 1.4219 0.79911 1.1926 0.98276 0.99855 BTB;zf-C2H2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transition metal ion binding;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 3 3 3 3.4 3.4 3.4 118.87 1.2769E-05 4496000 2511800 1984200 684 IPI:IPI00008137.1 Zinc finger protein 295;Zinc finger and BTB domain-containing protein 21 ZNF295;KIAA1227;ZBTB21 Q9ULJ3 ENST00000310826;ENST00000398499;ENST00000398511 1 0.74531 1.3581 0.75654 0.96742 0.87647 0.95142 Peptidase_S9;Peptidase_S9_N cell part;cytoplasm;intracellular part catalytic activity;endopeptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides;serine hydrolase activity;serine-type endopeptidase activity;serine-type peptidase activity biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis 26 26 26 44.5 44.5 44.5 80.699 0 922630000 502510000 420120000 685 IPI:IPI00008164.2 Prolyl endopeptidase;Post-proline cleaving enzyme PREP;PEP P48147 ENST00000369110 K01322 1 0.7161 1.4831 0.71538 0.99202 0.99931 0.89313 Na_K-ATPase cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;intracellular organelle;macromolecular complex;melanosome;membrane-bounded organelle;membrane-bounded vesicle;organelle;sodium:potassium-exchanging ATPase complex;vesicle binding;catalytic activity;ion transmembrane transporter activity;primary active transmembrane transporter activity;protein binding;sodium:potassium-exchanging ATPase activity;transporter activity ATP biosynthetic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;transport Cardiac muscle contraction 9 9 9 35.5 35.5 35.5 31.512 3.6614E-141 711180000 352460000 358720000 686 IPI:IPI00008167.1 Sodium/potassium-transporting ATPase subunit beta-3;Sodium/potassium-dependent ATPase subunit beta-3 ATP1B3 P54709 ENST00000286371 K01540 1 NaN NaN 0.60396 NaN NaN 0.76218 YEATS cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent 2 2 2 1.9 1.9 1.9 150.78 2.8735E-06 3212400 1817500 1394900 687 IPI:IPI00008200.2 YEATS domain-containing protein 2 YEATS2;KIAA1197 Q9ULM3 ENST00000305135 1 0.14902 0.21463 NaN 0.19916 0.12785 NaN Exo_endo_phos;LRR_1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;cation binding;exonuclease activity;hydrolase activity;hydrolase activity, acting on ester bonds;ion binding;magnesium ion binding;metal ion binding;nuclease activity;nucleic acid binding;protein binding;RNA binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 5 2 2 11.7 5.2 5.2 63.306 3.9607E-14 1038600 475760 562840 689 IPI:IPI00008205.3 CCR4-NOT transcription complex subunit 6;Carbon catabolite repressor protein 4 homolog;CCR4 carbon catabolite repression 4-like;Cytoplasmic deadenylase CNOT6;CCR4;KIAA1194 Q9ULM6 ENST00000261951;ENST00000393356;ENST00000393358 K01175 1 0.88351 1.8524 0.81865 1.1485 1.2028 1.1382 UBA;ubiquitin;XPC-binding cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;damaged DNA binding;DNA binding;nucleic acid binding;protein binding;single-stranded DNA binding;structure-specific DNA binding DNA metabolic process;DNA repair;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleotide-excision repair;proteolysis;response to stress;ubiquitin-dependent protein catabolic process Nucleotide excision repair 6 4 4 13.5 8.5 8.5 39.609 4.7704E-11 316810000 160050000 156750000 691 IPI:IPI00008219.1 UV excision repair protein RAD23 homolog A RAD23A P54725 ENST00000316856 K10839 1 0.87168 1.7394 0.84303 1.1243 1.109 1.1101 UBA;ubiquitin;XPC-binding cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;protein complex binding;damaged DNA binding;DNA binding;nucleic acid binding;protein binding;single-stranded DNA binding;structure-specific DNA binding DNA catabolic process;DNA metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleotide-excision repair, DNA damage removal;proteolysis;ubiquitin-dependent protein catabolic process Nucleotide excision repair 13 13 11 31.8 31.8 27.4 43.171 1.1198E-238 788940000 397010000 391930000 692 IPI:IPI00008223.3 UV excision repair protein RAD23 homolog B;XP-C repair-complementing complex 58 kDa protein RAD23B P54727 ENST00000358015 K10839 1 0.67971 1.3766 0.60441 0.92477 0.876 0.84182 CS;Cyt-b5;FAD_binding_6;NAD_binding_1 cell part;cytoplasmic part;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle;perinuclear region of cytoplasm binding;catalytic activity;cytochrome-b5 reductase activity;electron carrier activity;iron ion binding;NAD(P)H oxidase activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH detection of oxygen;generation of a signal involved in cell-cell signaling;generation of precursor metabolites and energy;metabolic process;oxygen and reactive oxygen species metabolic process;peptide secretion;superoxide metabolic process;transport 6 6 6 14.6 14.6 14.6 59.473 2.0809E-16 36605000 21023000 15582000 693 IPI:IPI00008236.6 Cytochrome b5 reductase 4;Flavohemoprotein b5/b5R;cb5/cb5R;N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein CYB5R4;NCB5OR Q7L1T6 ENST00000369681 1 0.78568 1.4962 0.79745 1.0253 0.99996 1.0446 GST_C;tRNA-synt_1g;WHEP-TRS cell part;cytoplasm;intracellular part;membrane;plasma membrane aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;ligase activity;methionine-tRNA ligase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;RNA binding;tRNA binding cellular amino acid and derivative metabolic process;methionyl-tRNA aminoacylation;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;tRNA aminoacylation for protein translation;tRNA metabolic process Aminoacyl-tRNA biosynthesis;Methionine metabolism;Selenoamino acid metabolism 31 31 31 38.9 38.9 38.9 101.11 0 1233400000 635400000 598030000 694 IPI:IPI00008240.2 Methionyl-tRNA synthetase, cytoplasmic;Methionine--tRNA ligase MARS P56192 ENST00000262027 K01874 1 0.49601 0.80521 0.36954 0.63521 0.54012 0.4803 anaphase-promoting complex;cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nuclear ubiquitin ligase complex;nucleoplasm;organelle part;protein complex;ubiquitin ligase complex acid-amino acid ligase activity;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;small conjugating protein ligase activity;ubiquitin-protein ligase activity catabolic process;cellular process;G2/M transition of mitotic cell cycle;macromolecule catabolic process;metabolic process;mitotic anaphase;proteasomal protein catabolic process;proteolysis;ubiquitin-dependent protein catabolic process Cell cycle;Cell cycle - yeast;Progesterone-mediated oocyte maturation;Ubiquitin mediated proteolysis 3 3 3 5.7 5.7 5.7 85.076 2.3556E-10 5455000 3352700 2102300 695 IPI:IPI00008247.2;IPI:IPI00375602.1 Anaphase-promoting complex subunit 5;Cyclosome subunit 5 ANAPC5;APC5 Q9UJX4-1;Q9UJX4 ENST00000261819;ENST00000344395 K03352 2 NaN NaN 0.93562 NaN NaN 1.264 CAP_C;CAP_N cell part;membrane;plasma membrane actin binding;binding;cytoskeletal protein binding;protein binding activation of adenylate cyclase activity;cell communication;cellular process;establishment or maintenance of cell polarity;regulation of biosynthetic process;regulation of nucleotide metabolic process;signal transduction 31 1 1 54.7 4.8 4.8 51.855 0 71323000 36458000 34865000 696 IPI:IPI00008274.7;IPI:IPI00027342.1 Adenylyl cyclase-associated protein 1 CAP1;CAP Q01518-1;Q01518 ENST00000340450;ENST00000372792;ENST00000372805 2 0.67815 1.2038 NaN 0.8845 0.86081 NaN Fe_hyd_lg_C cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to hypoxia;response to stress 2 2 2 5 5 5 53.02 0.0018642 4564600 2527300 2037200 697 IPI:IPI00008348.3;IPI:IPI00645749.1;IPI:IPI00847883.1 Nuclear prelamin A recognition factor-like protein;Protein related to Narf;Iron-only hydrogenase-like protein 1 NARFL;PRN Q9H6Q4-1;Q9H6Q4;Q9H6Q4-3;Q9H6Q4-2 ENST00000251588;ENST00000301694 3 0.84121 1.5786 0.94223 1.0632 1.0692 1.1576 SelT binding;selenium binding biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;regulation of biosynthetic process;regulation of translation;selenocysteine incorporation;translational elongation;translational readthrough 6 6 6 32.8 32.8 32.8 22.277 4.8917E-22 20344000 11174000 9169900 698 IPI:IPI00008351.3 Selenoprotein T SELT;UNQ150/PRO176 P62341 ENST00000361622;ENST00000397894 1 0.77873 1.4545 0.84393 1.0035 1.0286 1.047 Metallophos cell fraction;chromosome, centromeric region;cytosol;macromolecular complex;membrane-bounded organelle;mitochondrion;nucleus;organelle;protein phosphatase type 2A complex;protein serine/threonine phosphatase complex;soluble fraction;spindle binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;ion binding;iron ion binding;manganese ion binding;phosphatase activity;phosphoprotein phosphatase activity;phosphoric ester hydrolase activity;protein binding inactivation of MAPK activity;negative regulation of protein amino acid phosphorylation;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of cell growth;regulation of protein amino acid phosphorylation Long-term depression;TGF-beta signaling pathway;Tight junction;Wnt signaling pathway 14 14 12 58.6 58.6 53.7 35.594 0 1576600000 808550000 768090000 699 IPI:IPI00008380.1;IPI:IPI00429689.3 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Replication protein C;Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CA;PPP2CB P67775;P62714 ENST00000231504;ENST00000221138;ENST00000397308;ENST00000406655 K04382 2 0.8651 1.6156 0.92898 1.1012 1.1026 1.1679 Smac_DIABLO cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle binding;protein binding activation of caspase activity;activation of caspase activity by cytochrome c;induction of apoptosis;induction of apoptosis by extracellular signals;induction of apoptosis via death domain receptors;regulation of cell death 8 8 8 31.7 31.7 31.7 35.845 1.0101E-50 884390000 455030000 429360000 700 IPI:IPI00008418.6;IPI:IPI00219865.1 Diablo homolog, mitochondrial;Second mitochondria-derived activator of caspase;Direct IAP-binding protein with low pI DIABLO;SMAC Q9NR28-1;Q9NR28;Q9NR28-2 ENST00000267169;ENST00000342392 K10522 2 0.58142 1.1953 0.61855 0.74897 0.78808 0.79934 Helicase_C;SNF2_N cell part;intracellular organelle part;intracellular part;nuclear matrix;nuclear part;organelle part ATP binding;binding;catalytic activity;DNA binding;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity chromatin organization;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;organelle organization;protein complex assembly;regulation of DNA recombination 11 11 11 13.4 13.4 13.4 117.57 1.8605E-55 97264000 52420000 44844000 701 IPI:IPI00008422.5;IPI:IPI00220119.4 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1;ATP-dependent helicase 1 SMARCAD1;KIAA1122 Q9H4L7-2;Q9H4L7;Q9H4L7-1 ENST00000354268;ENST00000359052 2 0.71655 1.3111 0.71239 0.85685 0.94489 0.90409 Ribosomal_S7 cell part;cytoplasmic part;cytosolic part;cytosolic small ribosomal subunit;intracellular organelle part;intracellular part;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit binding;mRNA binding;nucleic acid binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;macromolecule biosynthetic process;metabolic process;regulation of translation;regulation of translational elongation;regulation of translational fidelity;translational elongation;translational initiation Ribosome 10 10 10 37.3 37.3 37.3 22.876 1.595E-227 5356000000 2769800000 2586200000 702 IPI:IPI00008433.4 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed RPS5 P46782 ENST00000196551 K02989 1 0.69978 1.4543 0.69019 0.91439 0.96174 0.91944 S10_plectin cell part;cytoplasmic part;cytosolic part;cytosolic small ribosomal subunit;intracellular organelle part;intracellular part;macromolecular complex;organelle;organelle part;ribonucleoprotein complex;ribosomal subunit;ribosome;small ribosomal subunit binding;protein binding biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 12 12 12 53.9 53.9 53.9 18.898 9.6909E-223 2287200000 1220200000 1066900000 704 IPI:IPI00008438.1;IPI:IPI00025842.1 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like protein RPS10;RPS10P5;RPS10L P46783;Q9NQ39 ENST00000326199;ENST00000344700;ENST00000217256 K02947 2 0.73201 1.6214 0.79545 0.96863 1.1049 1.0573 Urm1 cell part;cytoplasmic part;cytosol;intracellular part binding;protein binding nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;proteolysis;RNA processing;tRNA metabolic process;tRNA modification;tRNA processing;tRNA wobble base modification;tRNA wobble uridine modification 2 2 2 19.8 19.8 19.8 11.38 4.2246E-05 106620000 54378000 52240000 705 IPI:IPI00008445.3 Ubiquitin-related modifier 1 homolog URM1;C9orf74 Q9BTM9 ENST00000372853 1 0.81655 1.4525 0.73147 1.0634 0.97943 0.95033 Fip1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;RNA binding cellular biopolymer metabolic process;cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing 7 7 7 17.1 17.1 17.1 58.375 1.3022E-121 209640000 111460000 98179000 706 IPI:IPI00008449.1;IPI:IPI00395337.1;IPI:IPI00658114.3 Pre-mRNA 3'-end-processing factor FIP1;Factor interacting with PAP;FIP1-like 1;Rearranged in hypereosinophilia FIP1L1;FIP1;RHE Q6UN15-3;Q6UN15;Q6UN15-1;Q6UN15-4 ENST00000306932;ENST00000337488;ENST00000358575 3 1.0241 2.2463 0.91285 1.3995 1.4376 1.2523 DnaJ;DnaJ_C endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;membrane-enclosed lumen;organelle;organelle lumen;organelle part binding;heat shock protein binding;protein binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 7 7 7 24.6 24.6 24.6 40.513 2.8933E-142 176750000 90714000 86036000 707 IPI:IPI00008454.1 DnaJ homolog subfamily B member 11;ER-associated dnaJ protein 3;ERj3p;ERdj3;ER-associated Hsp40 co-chaperone;ER-associated DNAJ;HEDJ;hDj9;PWP1-interacting protein 4;APOBEC1-binding protein 2 DNAJB11;EDJ;ERJ3;PSEC0121;UNQ537/PRO1080 Q9UBS4 ENST00000265028 K09517 1 0.56211 0.91977 0.60357 0.7455 0.60218 0.80262 HMG_CoA_synt_C;HMG_CoA_synt_N cell fraction;cell part;cytoplasmic part;cytosol;intracellular part;soluble fraction catalytic activity;hydroxymethylglutaryl-CoA synthase activity;transferase activity;transferase activity, transferring acyl groups;transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer alcohol metabolic process;cholesterol biosynthetic process;cholesterol metabolic process;isoprenoid biosynthetic process;isoprenoid metabolic process;lipid metabolic process;metabolic process;steroid biosynthetic process;steroid metabolic process Butanoate metabolism;Synthesis and degradation of ketone bodies;Valine, leucine and isoleucine degradation 19 19 19 45.8 45.8 45.8 57.293 0 1503400000 801980000 701420000 708 IPI:IPI00008475.1;IPI:IPI00008934.1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic;3-hydroxy-3-methylglutaryl coenzyme A synthase HMGCS1;HMGCS Q01581 ENST00000325110 K01641 2 1.5051 2.7158 1.4697 2.1142 1.8101 2.046 Aurora-A_bind;TPX2 cytoskeletal part;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle;organelle part;spindle adenyl nucleotide binding;ATP binding;binding;GTP binding;guanyl nucleotide binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cell cycle phase;cell cycle process;cell proliferation;cellular component organization;cellular process;mitosis;nuclear division;organelle fission;organelle organization 20 20 20 32.5 32.5 32.5 85.652 1.5379E-242 477590000 219990000 257600000 709 IPI:IPI00008477.1 Targeting protein for Xklp2;Restricted expression proliferation-associated protein 100;Differentially expressed in cancerous and non-cancerous lung cells 2;Protein fls353;Hepatocellular carcinoma-associated antigen 519 TPX2;C20orf1;C20orf2;DIL2;HCA519 Q9ULW0 ENST00000300403;ENST00000340513 1 0.56212 1.1183 0.61001 0.76177 0.7072 0.80531 Aconitase;Aconitase_C cell part;cytoplasmic part;cytosol;endoplasmic reticulum;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle aconitate hydratase activity;binding;carbon-oxygen lyase activity;catalytic activity;cation binding;hydro-lyase activity;ion binding;iron ion binding;lyase activity;metal ion binding;nucleic acid binding;RNA binding;transition metal ion binding acetyl-CoA metabolic process;carboxylic acid metabolic process;catabolic process;cellular process;citrate metabolic process;coenzyme catabolic process;coenzyme metabolic process;metabolic process;organic acid metabolic process;tricarboxylic acid cycle Citrate cycle (TCA cycle);Glyoxylate and dicarboxylate metabolism;Reductive carboxylate cycle (CO2 fixation) 22 22 22 30.3 30.3 30.3 98.398 0 827170000 445780000 381390000 710 IPI:IPI00008485.1 Cytoplasmic aconitate hydratase;Citrate hydro-lyase;Iron-responsive element-binding protein 1;Iron regulatory protein 1;Ferritin repressor protein ACO1;IREB1 P21399 ENST00000309951;ENST00000379923 K01681 1 0.73794 1.3756 0.7207 0.96476 0.91172 0.93554 PABP;RRM_1 cell part;cytoplasm;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;mRNA binding;nucleic acid binding;nucleotide binding;poly(A) RNA binding;protein binding;protein C-terminus binding;RNA binding;single-stranded RNA binding;translation activator activity;translation factor activity, nucleic acid binding cellular process;metabolic process;mRNA polyadenylation;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of gene expression;RNA processing;RNA splicing 28 28 16 40.1 40.1 21.7 70.67 0 6733000000 3615900000 3117000000 714 IPI:IPI00008524.1;IPI:IPI00410017.1;IPI:IPI00301154.3;IPI:IPI00556259.3;IPI:IPI00061206.1;IPI:IPI00432527.1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 3;Testis-specific poly(A)-binding protein PABPC1;PAB1;PABP1;PABPC2;PABPC3;PABP3;PABPL3 P11940-1;P11940;P11940-2;Q9H361 ENST00000318607;ENST00000347137;ENST00000281589 6 0.69562 1.352 0.72005 0.94105 0.82753 0.95734 Ribosomal_60s cell part;cytoplasmic part;cytosolic large ribosomal subunit;cytosolic part;intracellular organelle part;intracellular part;large ribosomal subunit;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit binding;nucleic acid binding;protein binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 3 3 3 79.8 79.8 79.8 11.514 3.2079E-121 1212700000 688210000 524500000 715 IPI:IPI00008527.3 60S acidic ribosomal protein P1 RPLP1;RRP1 P05386 ENST00000260379 K02942 1 0.66062 1.4477 0.76089 0.91921 0.90896 1.0137 Ribosomal_60s cell part;cytoplasmic part;cytosolic large ribosomal subunit;cytosolic part;intracellular organelle part;intracellular part;large ribosomal subunit;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit binding;nucleic acid binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 9 9 9 83.5 83.5 83.5 11.665 0 6103700000 3290100000 2813600000 717 IPI:IPI00008529.1 60S acidic ribosomal protein P2;Renal carcinoma antigen NY-REN-44 RPLP2;D11S2243E;RPP2 P05387 ENST00000321153 K02943 1 0.66196 1.406 0.7127 0.87754 0.91776 0.91278 Ribosomal_60s;Ribosomal_L10 cell part;cytoplasmic part;cytosolic large ribosomal subunit;cytosolic part;intracellular organelle part;intracellular part;large ribosomal subunit;macromolecular complex;organelle;organelle part;ribonucleoprotein complex;ribosomal subunit;ribosome binding;nucleic acid binding;protein binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;ribonucleoprotein complex biogenesis;translational elongation Ribosome 19 19 19 56.8 56.8 56.8 34.273 0 6540900000 3493000000 3047900000 718 IPI:IPI00008530.1;IPI:IPI00871646.1 60S acidic ribosomal protein P0;L10E;60S acidic ribosomal protein P0-like RPLP0 P05388;Q8NHW5 ENST00000228306;ENST00000392514 K02941 2 0.62257 1.5321 0.73962 0.83874 0.97438 1.0005 ELM2;Myb_DNA-binding cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;protein binding biosynthetic process;chromatin organization;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;regulation of transcription, DNA-dependent;transcription Huntington's disease 9 9 6 21.4 21.4 15.6 53.027 2.7511E-39 100770000 55746000 45026000 719 IPI:IPI00008531.1 REST corepressor 1;Protein CoREST RCOR1;KIAA0071;RCOR Q9UKL0 ENST00000262241 K11829 1 0.56125 1.1544 0.70457 0.7827 0.69501 0.87471 YEATS H4/H2A histone acetyltransferase complex;histone acetyltransferase complex;intracellular organelle part;intracellular part;macromolecular complex;NuA4 histone acetyltransferase complex;nuclear matrix;nuclear part;organelle part;protein complex binding;DNA binding;nucleic acid binding;protein binding;protein C-terminus binding;structural constituent of cytoskeleton;structural molecule activity;transcription factor activity;transcription regulator activity chromatin organization;nuclear division;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein amino acid acetylation;protein modification process;regulation of transcription, DNA-dependent;transcription 4 4 4 24.2 24.2 24.2 26.499 9.5304E-10 27681000 14865000 12816000 720 IPI:IPI00008536.3 YEATS domain-containing protein 4;Glioma-amplified sequence 41;NuMA-binding protein 1 YEATS4;GAS41 O95619 ENST00000247843 K11341 1 0.69959 1.4499 0.71567 0.93315 0.94249 0.9322 Glutaredoxin;Thioredoxin cell cortex;cell part;cytoplasmic part;intracellular part binding;catalytic activity;disulfide oxidoreductase activity;electron carrier activity;oxidoreductase activity;oxidoreductase activity, acting on sulfur group of donors;protein binding;protein disulfide oxidoreductase activity biological regulation;cell redox homeostasis;cellular homeostasis;cellular process;homeostatic process;regulation of biological process;regulation of biological quality;regulation of cellular process 18 18 18 40.9 40.9 40.9 37.432 1.0628E-193 1341900000 720760000 621120000 721 IPI:IPI00008552.6 Glutaredoxin-3;Thioredoxin-like protein 2;PKC-interacting cousin of thioredoxin;PKC-theta-interacting protein GLRX3;PICOT;TXNL2;HUSSY-22 O76003 ENST00000331244;ENST00000368644 1 0.6041 NaN NaN 0.75074 NaN NaN KH_1;RRM_1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;mRNA 5'-UTR binding;mRNA binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding;translation regulator activity negative regulation of biosynthetic process;negative regulation of metabolic process;regulation of biosynthetic process;regulation of cytokine production;regulation of gene expression;regulation of translation 3 2 2 5.7 3.5 3.5 63.456 8.8551E-08 2622100 1353200 1268900 722 IPI:IPI00008557.5 Insulin-like growth factor 2 mRNA-binding protein 1;IGF-II mRNA-binding protein 1;Coding region determinant-binding protein;VICKZ family member 1;Zip code-binding protein 1 IGF2BP1;CRDBP;VICKZ1;ZBP1 Q9NZI8 ENST00000290341 1 1.0468 1.9657 0.93585 1.4143 1.2804 1.2332 Synaptobrevin cytoplasmic vesicle membrane;cytosol;endoplasmic reticulum;endosome;Golgi membrane;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane;organelle membrane;SNARE complex;vesicle membrane acyltransferase activity;binding;catalytic activity;palmitoyltransferase activity;protein binding;S-acyltransferase activity;SNAP receptor activity;transferase activity;transferase activity, transferring acyl groups cellular process;endosome transport;ER to Golgi vesicle-mediated transport;membrane docking;protein transport;retrograde transport, endosome to Golgi;transport;vesicle docking during exocytosis;vesicle targeting;vesicle-mediated transport SNARE interactions in vesicular transport 9 9 9 58.1 58.1 58.1 22.417 1.8282E-93 147800000 78053000 69746000 723 IPI:IPI00008569.1 Synaptobrevin homolog YKT6 YKT6 O15498 ENST00000223369 K08516 1 NaN 1.9549 NaN NaN 1.3039 NaN cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;protein binding;protein domain specific binding;RNA binding;SH3 domain binding biosynthetic process;gamete generation;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;spermatogenesis;transcription 4 2 2 10.1 5.8 5.8 38.799 1.2756E-05 2504200 1257700 1246500 724 IPI:IPI00008570.1;IPI:IPI00744983.1 KH domain-containing, RNA-binding, signal transduction-associated protein 3;Sam68-like mammalian protein 2;Sam68-like phosphotyrosine protein;RNA-binding protein T-Star KHDRBS3;SALP;SLM2 O75525-1;O75525;O75525-2 ENST00000355849;ENST00000395313 2 0.77229 2.0264 0.79815 1.1184 1.0763 1.1364 KH_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;protein binding;protein domain specific binding;RNA binding;SH3 domain binding;SH3/SH2 adaptor activity;signal transducer activity;transcription regulator activity;transcription repressor activity cell cycle arrest;G2/M transition of mitotic cell cycle;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;RNA processing;transcription 10 10 8 18.7 18.7 17.4 48.227 2.7179E-208 979710000 503620000 476100000 725 IPI:IPI00008575.3;IPI:IPI00385834.3;IPI:IPI00082310.1 KH domain-containing, RNA-binding, signal transduction-associated protein 1;p21 Ras GTPase-activating protein-associated p62;GAP-associated tyrosine phosphoprotein p62;Src-associated in mitosis 68 kDa protein;p68 KHDRBS1;SAM68 Q07666-1;Q07666;Q07666-2;Q07666-3 ENST00000307714;ENST00000327300;ENST00000355201 3 NaN 1.6861 NaN NaN 1.1919 NaN V-set cell part;cell surface;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane part;membrane raft;plasma membrane part binding;cell adhesion molecule binding;enzyme binding;integrin binding;kinase binding;molecular transducer activity;protein binding;protein complex binding;protein kinase binding;receptor activity;receptor binding;signal transducer activity positive regulation of immune system process;positive regulation of leukocyte mediated cytotoxicity;regulation of immune system process;regulation of leukocyte activation;regulation of leukocyte mediated cytotoxicity Cell adhesion molecules (CAMs) 2 2 2 10.1 10.1 10.1 38.584 6.913E-10 883110 412190 470920 726 IPI:IPI00008578.1 CD226 antigen;DNAX accessory molecule 1 CD226;DNAM1 Q15762 ENST00000280200 K06567 1 0.72515 1.5242 0.78783 0.98712 1.0072 1.0791 FDX-ACB;tRNA-synt_2d cell fraction;cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part;soluble fraction aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;ligase activity;magnesium ion binding;nucleic acid binding;nucleoside binding;nucleotide binding;phenylalanine-tRNA ligase activity;purine nucleoside binding;RNA binding;tRNA binding nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;phenylalanyl-tRNA aminoacylation;RNA processing;tRNA aminoacylation for protein translation;tRNA metabolic process Aminoacyl-tRNA biosynthesis;Phenylalanine, tyrosine and tryptophan biosynthesis 3 3 3 6.9 6.9 6.9 52.356 4.3477E-20 33114000 19965000 13150000 727 IPI:IPI00008579.3 Phenylalanyl-tRNA synthetase, mitochondrial;Phenylalanine--tRNA ligase FARS2;FARS1;HSPC320 O95363 ENST00000274680;ENST00000324331 K01889 1 0.72715 1.3686 0.75596 0.88294 1.0038 0.92639 EBP cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;integral to plasma membrane;intracellular part;intrinsic to membrane;intrinsic to plasma membrane;membrane;membrane part;organelle membrane;organelle part catalytic activity;drug transporter activity;intramolecular oxidoreductase activity;isomerase activity;receptor activity;signal transducer activity;steroid delta-isomerase activity;transmembrane receptor activity;transporter activity alcohol metabolic process;cholesterol biosynthetic process;cholesterol metabolic process;lipid biosynthetic process;lipid metabolic process;metabolic process;skeletal system development;steroid biosynthetic process;steroid metabolic process Biosynthesis of steroids 2 2 2 11.3 11.3 11.3 26.352 5.7936E-83 319700000 166140000 153560000 728 IPI:IPI00008599.3 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase;Cholestenol Delta-isomerase;Delta(8)-Delta(7) sterol isomerase;Emopamil-binding protein EBP Q15125 ENST00000276096 K01824 1 0.8952 2.1508 0.87379 1.2008 1.4916 1.1109 Actin cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding Vascular smooth muscle contraction 35 14 1 74 46.9 2.9 42.009 0 16150000000 8306900000 7843500000 729 IPI:IPI00008603.1;IPI:IPI00025416.3 Actin, aortic smooth muscle;Alpha-actin-2;Cell growth-inhibiting gene 46 protein;Actin, gamma-enteric smooth muscle;Smooth muscle gamma-actin;Gamma-2-actin;Alpha-actin-3 ACTA2;ACTSA;ACTVS;GIG46;ACTG2;ACTA3;ACTL3;ACTSG P62736;P63267 ENST00000224784;ENST00000345517;ENST00000409624 K12313;K12315 2 0.52364 1.8763 0.78133 0.67701 1.176 1.0429 AA_permease cell part;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part anion transmembrane transporter activity;binding;cation transmembrane transporter activity;ion transmembrane transporter activity;secondary active transmembrane transporter activity;solute:cation symporter activity;symporter activity;transporter activity anion transport;cation transport;chloride transport;establishment of localization;inorganic anion transport;ion transport;metal ion transport;monovalent inorganic cation transport;potassium ion transport;sodium ion transport;transport 8 8 7 9.3 9.3 8 119.1 3.718E-111 40609000 23450000 17159000 730 IPI:IPI00008616.3 Solute carrier family 12 member 7;Electroneutral potassium-chloride cotransporter 4;K-Cl cotransporter 4 SLC12A7;KCC4 Q9Y666-1;Q9Y666 ENST00000264930;ENST00000343658 1 0.53787 1.3024 0.56733 0.75152 0.82674 0.75997 cytoplasmic part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;ribonucleoprotein complex;ribosome binding;nucleic acid binding;protein binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;translation 19 19 19 36.5 36.5 36.5 54.972 1.5791E-251 1274600000 717140000 557500000 732 IPI:IPI00008708.5 Ribosomal L1 domain-containing protein 1;Cellular senescence-inhibited gene protein;Protein PBK1;CATX-11 RSL1D1;CATX11;CSIG;PBK1;L12 O76021 ENST00000396503 1 0.6662 1.3019 0.67631 0.91659 0.83336 0.87633 AAA_2;ClpB_D2-small endopeptidase Clp complex;macromolecular complex;membrane;mitochondrial endopeptidase Clp complex;mitochondrial inner membrane;mitochondrial membrane;mitochondrial nucleoid;nucleoid;organelle inner membrane;organelle membrane;protein complex ATP binding;binding;catalytic activity;enzyme activator activity;hydrolase activity;nucleoside binding;nucleotide binding;peptidase activator activity;protein binding;purine nucleoside binding;pyrophosphatase activity;zinc ion binding catabolic process;cellular biopolymer catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;protein catabolic process;protein metabolic process;protein transport;proteolysis;transport 13 13 13 25.3 25.3 25.3 69.223 8.0647E-68 284730000 152430000 132290000 734 IPI:IPI00008728.1 ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial CLPX O76031 ENST00000300107 K03544 1 0.43525 0.89154 0.37478 0.59943 0.58352 0.48702 TraB 5 5 5 19.1 19.1 19.1 42.321 1.981E-18 64436000 37480000 26956000 735 IPI:IPI00008732.1;IPI:IPI00748784.2 TraB domain-containing protein TRABD;PP2447 Q9H4I3-1;Q9H4I3;Q9H4I3-2 ENST00000303434;ENST00000380909;ENST00000395827;ENST00000395829 2 0.88076 1.4709 0.77634 1.2295 0.92869 1.0459 GST_C;GST_N cell part;cytoplasm;intracellular part catalytic activity;glutathione transferase activity;transferase activity;transferase activity, transferring alkyl or aryl (other than methyl) groups metabolic process Drug metabolism - cytochrome P450;Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450 6 2 2 35.8 10.6 10.6 25.561 9.0322E-136 11952000 6262700 5688900 736 IPI:IPI00008770.1;IPI:IPI00470739.4 Glutathione S-transferase Mu 4;GSTM4-4;GST class-mu 4;GTS-Mu2 GSTM4 Q03013-1;Q03013;Q03013-2 ENST00000326729;ENST00000369836 K00799 2 1.2797 1.3939 0.72924 1.582 0.88277 0.89707 WD40 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding biosynthetic process;cellular process;metabolic process;positive regulation of cell proliferation;regulation of biosynthetic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent 5 5 5 18.6 18.6 18.6 37.84 6.3347E-57 30663000 17158000 13505000 738 IPI:IPI00008791.1 Protein CIAO1;WD repeat-containing protein 39 CIAO1;WDR39 O76071 ENST00000272402 1 0.57196 1.2269 0.67337 0.77656 0.79877 0.86015 CIDE-N;DFF40 cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;caspase-activated deoxyribonuclease activity;catalytic activity;deoxyribonuclease activity;enzyme binding;hydrolase activity;hydrolase activity, acting on ester bonds;nuclease activity;protein binding DNA catabolic process;DNA catabolic process, endonucleolytic;DNA fragmentation involved in apoptosis;DNA metabolic process;DNA packaging;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Apoptosis 4 4 4 14.5 14.5 14.5 39.109 6.5578E-08 30432000 16821000 13611000 739 IPI:IPI00008794.1;IPI:IPI00179341.2;IPI:IPI00218518.1;IPI:IPI00883793.1 DNA fragmentation factor subunit beta;DNA fragmentation factor 40 kDa subunit;Caspase-activated deoxyribonuclease DFFB;CAD;DFF2;DFF40 O76075-1;O76075;O76075-2 ENST00000338895;ENST00000341385;ENST00000378209;ENST00000378212 K02311 4 0.53878 1.2978 0.44582 0.7454 0.81232 0.62624 HECT;RCC1 cell part;cytoplasmic part;intracellular part;perinuclear region of cytoplasm acid-amino acid ligase activity;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds catabolic process;cellular process;macromolecule catabolic process;metabolic process;protein modification process;proteolysis;regulation of cyclin-dependent protein kinase activity;regulation of metabolic process;regulation of phosphate metabolic process 9 9 9 10 10 10 116.85 1.8961E-38 66247000 40996000 25250000 740 IPI:IPI00008821.1 Probable E3 ubiquitin-protein ligase HERC5;HECT domain and RCC1-like domain-containing protein 5;Cyclin-E-binding protein 1 HERC5;CEB1;CEBP1 Q9UII4 ENST00000264350 1 0.95883 1.6976 0.90481 1.2334 1.048 1.2781 LIM actin filament bundle;actomyosin;adherens junction;cell junction;cell-substrate adherens junction;cell-substrate junction;cytoplasm;cytoskeletal part;focal adhesion;intracellular organelle part;intracellular part;membrane part;organelle part;stress fiber actin binding;actin filament binding;actin monomer binding;binding;cation binding;cytoskeletal protein binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding actin filament organization;cellular process;cytoskeleton organization;negative regulation of macromolecule metabolic process;negative regulation of metabolic process;organelle organization;regulation of actin polymerization or depolymerization 13 13 13 22.7 22.7 22.7 85.225 4.6428E-201 331940000 162230000 169700000 742 IPI:IPI00008918.1;IPI:IPI00796705.2;IPI:IPI00220466.1 LIM domain and actin-binding protein 1;Epithelial protein lost in neoplasm LIMA1;EPLIN;SREBP3;PP624 Q9UHB6-1;Q9UHB6;Q9UHB6-2;Q9UHB6-3 ENST00000341247;ENST00000394943 3 0.77028 1.5004 0.87855 0.97241 1.0164 1.1155 Myb_DNA-bind_2 chromosomal part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;Mre11 complex;nuclear part;nuclear telomere cap complex;nucleoplasm;organelle part;protein complex;protein-DNA complex;telomere cap complex binding;DNA binding;nucleic acid binding;protein binding DNA metabolic process;DNA replication;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to DNA damage stimulus;response to stress;RNA-dependent DNA replication;telomere maintenance 10 10 10 34.6 34.6 34.6 44.259 2.3403E-189 333990000 167260000 166730000 743 IPI:IPI00008961.1 Telomeric repeat-binding factor 2-interacting protein 1;TRF2-interacting telomeric protein Rap1 TERF2IP;RAP1;PP8000 Q9NYB0 ENST00000300086 K11113 1 0.85339 1.9553 0.92842 1.1039 1.224 1.218 Ras cell part;cytoplasm;cytoplasmic part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;organelle binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;protein binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cell communication;cellular process;establishment of protein localization;intracellular signaling cascade;protein transport;regulation of biological process;signal transduction;small GTPase mediated signal transduction;transport 14 12 6 81.1 70.1 37.8 22.171 2.6063E-290 1744500000 883070000 861400000 744 IPI:IPI00008964.3;IPI:IPI00374519.3;IPI:IPI00394882.2;IPI:IPI00383449.2 Ras-related protein Rab-1B;Putative Ras-related protein Rab-1C RAB1B;RAB1C Q9H0U4;Q92928 ENST00000311481 K07875 4 0.51644 1.0974 0.53339 0.69302 0.73257 0.67357 AA_kinase cell part;cytoplasmic part;intracellular organelle part;intracellular part;membrane;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part ATP binding;binding;catalytic activity;glutamate 5-kinase activity;glutamate-5-semialdehyde dehydrogenase activity;kinase activity;nucleoside binding;nucleotide binding;oxidoreductase activity;purine nucleoside binding cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;metabolic process;nitrogen compound metabolic process;organic acid metabolic process;proline biosynthetic process;proline metabolic process Arginine and proline metabolism 24 24 24 37 37 37 87.301 3.9225E-291 787490000 440010000 347480000 745 IPI:IPI00008982.1;IPI:IPI00218547.1 Delta-1-pyrroline-5-carboxylate synthetase;Aldehyde dehydrogenase family 18 member A1;Glutamate 5-kinase;Gamma-glutamyl kinase;Gamma-glutamyl phosphate reductase;Glutamate-5-semialdehyde dehydrogenase;Glutamyl-gamma-semialdehyde dehydrogenase ALDH18A1;GSAS;P5CS;PYCS P54886-1;P54886;P54886-2 ENST00000371221;ENST00000371224 K00147;K00931 2 1.1088 1.685 0.90359 1.3455 1.2059 1.2203 AA_permease apical plasma membrane;cell part;cytoplasmic part;cytosol;integral to membrane;intracellular part;intrinsic to membrane;membrane part;plasma membrane part amine transmembrane transporter activity;amino acid transmembrane transporter activity;antigen binding;binding;neutral amino acid transmembrane transporter activity;organic acid transmembrane transporter activity;transporter activity amino acid transport;cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;metabolic process;nervous system development;nitrogen compound metabolic process;organic acid metabolic process;transport 5 5 4 11.2 11.2 9.9 55.01 2.2685E-128 1339000000 642190000 696840000 746 IPI:IPI00008986.1;IPI:IPI00549477.1 Large neutral amino acids transporter small subunit 1;L-type amino acid transporter 1;Solute carrier family 7 member 5;y+ system cationic amino acid transporter;4F2 light chain;CD98 light chain;Integral membrane protein E16 SLC7A5;CD98LC;LAT1;MPE16 Q01650 ENST00000261622 K03450 2 0.79489 1.3966 0.87587 1.0145 0.92292 1.0821 CBFD_NFYB_HMF cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;protein binding;sequence-specific DNA binding;transcription cofactor activity;transcription corepressor activity;transcription factor binding;transcription regulator activity;transcription repressor activity negative regulation of transcription from RNA polymerase II promoter;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 3 3 3 23.3 23.3 23.3 19.443 2.864E-44 152480000 80280000 72203000 747 IPI:IPI00008991.1 Protein Dr1;Down-regulator of transcription 1;TATA-binding protein-associated phosphoprotein;Negative cofactor 2-beta DR1 Q01658 ENST00000370267;ENST00000370272 1 0.87671 1.2416 0.82891 1.1406 0.86779 1.0956 Ndr centrosome;cytosol;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;microtubule organizing center;non-membrane-bounded organelle;nucleus;organelle;organelle part anatomical structure development;cell differentiation;cellular developmental process;cellular process;developmental process;nervous system development;system development 2 2 2 7.3 7.3 7.3 40.798 5.5285E-31 5509800 2722900 2786900 748 IPI:IPI00008994.2;IPI:IPI00218109.3;IPI:IPI00218108.1;IPI:IPI00759789.1;IPI:IPI00384121.2 Protein NDRG2;Protein Syld709613 NDRG2;KIAA1248;SYLD Q9UN36-1;Q9UN36;Q9UN36-3;Q9UN36-2;Q9UN36-5;Q9UN36-4 ENST00000298687;ENST00000350792;ENST00000397851;ENST00000397853;ENST00000397855;ENST00000397856;ENST00000397858;ENST00000403829 5 0.88559 1.642 0.86219 1.148 1.1344 1.0962 CS;PTPLA cell part;integral to membrane;intrinsic to membrane;membrane part binding;enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity;protein binding activation of MAPK activity;cell communication;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;regulation of protein amino acid phosphorylation;signal transduction 8 8 8 22.4 22.4 22.4 43.159 1.7113E-94 277070000 139270000 137800000 749 IPI:IPI00008998.3 Protein tyrosine phosphatase-like protein PTPLAD1;Protein-tyrosine phosphatase-like A domain-containing protein 1;Butyrate-induced protein 1 PTPLAD1;BIND1 Q9P035 ENST00000261875 1 NaN 2.8604 NaN NaN 1.7583 NaN HLH cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;RNA polymerase II transcription factor activity;RNA polymerase II transcription factor activity, enhancer binding;transcription coactivator activity;transcription cofactor activity;transcription factor activity nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 3 3 3 11.5 11.5 11.5 38.725 1.6256E-09 7346500 3709500 3637000 750 IPI:IPI00009005.1 Transcription factor AP-4;Activating enhancer-binding protein 4 TFAP4 Q01664 ENST00000204517 K09108 1 0.83633 1.5887 0.91056 1.1044 1.0488 1.1514 Cwf_Cwc_15 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 2 2 2 15.7 15.7 15.7 26.624 1.2417E-70 90201000 50342000 39859000 751 IPI:IPI00009009.4 Protein CWC15 homolog CWC15;C11orf5;AD-002;HSPC148 Q9P013 ENST00000279839 1 0.91349 1.395 0.93908 1.1039 0.99562 1.0989 Trm112p binding;protein binding 5 5 5 47.2 47.2 47.2 14.199 1.1606E-128 721100000 339930000 381170000 752 IPI:IPI00009010.3 TRM112-like protein AD-001;HSPC152;HSPC170 Q9UI30 ENST00000308774 1 0.91513 1.6703 0.92563 1.1051 1.1849 1.1684 Lamp cell fraction;cytoplasmic vesicle membrane;endosome;endosome membrane;insoluble fraction;integral to membrane;late endosome;lysosomal membrane;membrane;membrane fraction;plasma membrane;secretory granule membrane;vacuolar membrane;vesicle membrane carbohydrate metabolic process;cellular glucan metabolic process;cellular process;energy reserve metabolic process;generation of precursor metabolites and energy;glycogen metabolic process;metabolic process;polysaccharide metabolic process 3 3 3 7.1 7.1 7.1 44.96 1.0492E-18 222230000 112170000 110060000 753 IPI:IPI00009030.1;IPI:IPI00739827.1 Lysosome-associated membrane glycoprotein 2;CD107 antigen-like family member B LAMP2 P13473-1;P13473;P13473-2 ENST00000200639;ENST00000371335;ENST00000371345 2 0.70063 1.5685 0.75644 0.98178 0.95645 1.0404 La;RRM_1;RRM_3 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;ribonucleoprotein complex binding;mRNA binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding;tRNA binding histone mRNA metabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA modification;RNA processing;tRNA metabolic process;tRNA modification;tRNA processing Systemic lupus erythematosus 36 36 36 64.5 64.5 64.5 46.836 0 2839800000 1497400000 1342400000 754 IPI:IPI00009032.1 Lupus La protein;Sjoegren syndrome type B antigen;La ribonucleoprotein;La autoantigen SSB P05455 ENST00000260956;ENST00000409333 K11090 1 0.79732 1.458 0.8084 1.0782 0.99898 1.0599 NTF2;RRM_1 cell part;cytoplasm;intracellular part binding;nucleic acid binding;nucleotide binding;protein binding;protein complex scaffold;receptor signaling complex scaffold activity;RNA binding;structural molecule activity cell communication;cellular process;cytoplasmic sequestering of NF-kappaB;intracellular signaling cascade;Ras protein signal transduction;signal transduction;small GTPase mediated signal transduction;transport 13 11 11 36.3 33.6 33.6 54.12 1.3361E-248 949620000 495020000 454610000 755 IPI:IPI00009057.2;IPI:IPI00179890.2 Ras GTPase-activating protein-binding protein 2;G3BP-2;GAP SH3 domain-binding protein 2 G3BP2;KIAA0660 Q9UN86-1;Q9UN86;Q9UN86-2 ENST00000357854;ENST00000359707;ENST00000395719 2 0.77479 1.4265 0.8369 1.0495 0.95567 1.1099 DUF1916;GTP_EFTU;GTP_EFTU_D2;GTP_EFTU_D3 binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;nucleic acid binding;nucleotide binding;pyrophosphatase activity;translation elongation factor activity;translation factor activity, nucleic acid binding biosynthetic process;cell communication;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;signal transduction;translation 13 13 11 22.8 22.8 20 75.472 6.7539E-166 172610000 89884000 82724000 756 IPI:IPI00009070.1;IPI:IPI00513811.1 HBS1-like protein;ERFS HBS1L;HBS1;KIAA1038 Q9Y450-1;Q9Y450;Q9Y450-3 ENST00000367822;ENST00000367837 2 0.85414 1.453 0.86818 1.1174 0.99645 1.0859 RRM_1 cell part;cytoplasm;intracellular organelle part;intracellular part;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part binding;catalytic activity;nucleic acid binding;nucleotide binding;protein binding;protein domain specific binding;RNA binding;RNA splicing factor activity, transesterification mechanism;RS domain binding;unfolded protein binding assembly of spliceosomal tri-snRNP;cellular process;mRNA export from nucleus;mRNA splice site selection;negative regulation of metabolic process;nucleocytoplasmic transport;regulation of biosynthetic process;RNA export from nucleus;transport 7 7 7 24.4 24.4 24.4 31.3 2.3248E-96 570480000 289550000 280930000 757 IPI:IPI00074587.8;IPI:IPI00412643.1;IPI:IPI00009071.3;IPI:IPI00386662.1;IPI:IPI00942141.1 FUS-interacting serine-arginine-rich protein 1;TLS-associated protein with Ser-Arg repeats;TLS-associated serine-arginine protein;40 kDa SR-repressor protein;Splicing factor SRp38 FUSIP1;FUSIP2;TASR O75494-1;O75494;O75494-2;O75494-3;O75494-4 ENST00000341154;ENST00000343255;ENST00000374449;ENST00000374452;ENST00000374456;ENST00000374457 5 0.80052 1.4322 0.76591 0.98383 0.98894 0.98891 AAA;TIP49 cytoplasm;H4/H2A histone acetyltransferase complex;histone acetyltransferase complex;intracellular part;macromolecular complex;membrane;NuA4 histone acetyltransferase complex;nuclear matrix;nuclear part;organelle part;protein complex ATP binding;ATP-dependent DNA helicase activity;binding;catalytic activity;damaged DNA binding;DNA binding;DNA helicase activity;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding chromatin organization;DNA metabolic process;DNA recombination;DNA repair;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein folding;protein modification process;regulation of transcription, DNA-dependent;transcription 30 30 30 60.7 60.7 60.7 51.156 0 3981200000 2216700000 1764500000 758 IPI:IPI00009104.7 RuvB-like 2;48 kDa TATA box-binding protein-interacting protein;TIP49b;Repressing pontin 52;51 kDa erythrocyte cytosolic protein;TIP60-associated protein 54-beta;INO80 complex subunit J RUVBL2;INO80J;TIP48;TIP49B;CGI-46 Q9Y230 ENST00000221413 K11338 1 0.75651 1.7575 0.84642 1.063 1.1103 1.1501 cytosol;ER-Golgi intermediate compartment;extracellular region part;extracellular space;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;organelle;plasma membrane binding;calcium ion binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding 12 12 12 38.1 38.1 38.1 50.195 5.1923E-78 608940000 305250000 303690000 759 IPI:IPI00009123.2;IPI:IPI00922708.1 Nucleobindin-2;DNA-binding protein NEFA;Gastric cancer antigen Zg4 NUCB2;NEFA P80303-1;P80303;P80303-2 ENST00000323688 2 0.63602 1.5291 NaN 0.90358 0.95797 NaN zf-CCCH;zf-CCHC cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;nucleic acid binding;RNA binding;transition metal ion binding;zinc ion binding cellular biopolymer metabolic process;cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing 4 4 4 17.5 17.5 17.5 30.255 3.5605E-19 25758000 19839000 5919400 760 IPI:IPI00009137.1;IPI:IPI00029707.3;IPI:IPI00375469.1 Cleavage and polyadenylation specificity factor subunit 4;Cleavage and polyadenylation specificity factor 30 kDa subunit;NS1 effector domain-binding protein 1;No arches homolog CPSF4;CPSF30;NAR;NEB1 O95639-1;O95639;O95639-2;O95639-3 ENST00000292476 3 0.80807 1.4824 0.69757 1.005 1.0086 0.89045 NUDIX cell part;cytoplasm;intracellular part binding;catalytic activity;diphosphoinositol-polyphosphate diphosphatase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;magnesium ion binding;pyrophosphatase activity catabolic process;cell communication;cell-cell signaling;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside metabolic process;purine nucleoside catabolic process 3 3 3 25.6 25.6 25.6 19.471 1.7463E-13 60461000 32133000 28328000 762 IPI:IPI00009148.1 Diphosphoinositol polyphosphate phosphohydrolase 1;Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1;Nucleoside diphosphate-linked moiety X motif 3 NUDT3;DIPP;DIPP1 O95989 ENST00000358797 K07766 1 0.81441 1.5681 0.9483 1.1224 1.0693 1.2132 DSPc cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;ion binding;phosphatase activity;phosphoprotein phosphatase activity;phosphoric ester hydrolase activity;protein tyrosine phosphatase activity;zinc ion binding cellular biopolymer metabolic process;cellular process;dephosphorylation;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid dephosphorylation;protein metabolic process;protein modification process 9 9 9 34.7 34.7 34.7 37.687 3.1597E-136 189030000 98849000 90176000 763 IPI:IPI00009210.1 Dual specificity protein phosphatase 12;Dual specificity tyrosine phosphatase YVH1 DUSP12 Q9UNI6 ENST00000367943 K01090;K01104 1 0.81046 1.7781 0.93578 1.0688 1.1745 1.2475 SNARE endoplasmic reticulum;Golgi apparatus;integral to membrane;integral to plasma membrane;intracellular membrane-bounded organelle;intracellular organelle;intrinsic to membrane;intrinsic to plasma membrane;membrane-bounded organelle;nucleus;organelle establishment of localization;transport SNARE interactions in vesicular transport 4 4 4 11.4 11.4 11.4 26.906 1.7903E-10 81428000 41247000 40181000 764 IPI:IPI00009225.1 Syntaxin-8 STX8 Q9UNK0 ENST00000306357 K08501 1 0.94809 1.9123 1.0083 1.2053 1.2282 1.2709 NSF cell part;cytoplasmic part;endoplasmic reticulum;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;organelle cellular component organization;cellular process;establishment of localization;Golgi vesicle transport;intracellular transport;intra-Golgi vesicle-mediated transport;membrane fusion;membrane organization;transport;vesicle-mediated transport 21 21 21 73.6 73.6 73.6 33.232 0 1300600000 640590000 660020000 766 IPI:IPI00009253.2;IPI:IPI00748037.3 Alpha-soluble NSF attachment protein;N-ethylmaleimide-sensitive factor attachment protein alpha NAPA;SNAPA P54920 ENST00000263354 2 NaN 1.703 0.56502 NaN 1.0871 0.76794 AT_hook;FYRC;FYRN;PHD;SET;zf-CXXC cell part;histone methyltransferase complex;intracellular organelle part;intracellular part;macromolecular complex;methyltransferase complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;catalytic activity;DNA binding;methyltransferase activity;N-methyltransferase activity;nucleic acid binding;protein binding;RNA polymerase II transcription factor activity;transcription factor activity;zinc ion binding chromatin organization;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein complex assembly;regulation of transcription, DNA-dependent;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent 5 5 5 1.7 1.7 1.7 431.76 3.958E-09 31662000 26421000 5240400 768 IPI:IPI00009286.4;IPI:IPI00218500.6 Histone-lysine N-methyltransferase HRX;Zinc finger protein HRX;ALL-1;Trithorax-like protein;Lysine N-methyltransferase 2A;CXXC-type zinc finger protein 7 MLL;ALL1;CXXC7;HRX;HTRX;KMT2A;TRX1 Q03164-1;Q03164;Q03164-2 ENST00000354520;ENST00000359313 K09186 2 0.43593 0.81361 0.36486 0.55015 0.579 0.46707 ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cellular biopolymer metabolic process;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process 2 2 2 4.2 4.2 4.2 52.881 1.0766E-10 15482000 8768200 6713900 769 IPI:IPI00009291.1;IPI:IPI00375335.1 Serine/threonine-protein kinase VRK3;Vaccinia-related kinase 3 VRK3 Q8IV63-1;Q8IV63;Q8IV63-2 ENST00000316763 2 0.7801 1.7293 0.78672 1.1099 1.0545 1.1681 PCI cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex;signalosome 7 7 7 34.1 34.1 34.1 29.622 1.6271E-183 222130000 137420000 84706000 771 IPI:IPI00009301.1;IPI:IPI00478990.3 COP9 signalosome complex subunit 7b;JAB1-containing signalosome subunit 7b COPS7B;CSN7B Q9H9Q2-1;Q9H9Q2;Q9H9Q2-2 ENST00000350033;ENST00000410017;ENST00000410024 K12180 2 0.85536 1.6081 0.80544 1.0742 1.1077 1.0717 Glucosamine_iso cell part;cytoplasmic part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle catalytic activity;deaminase activity;glucosamine-6-phosphate deaminase activity;hydrolase activity;intramolecular oxidoreductase activity;intramolecular oxidoreductase activity, interconverting aldoses and ketoses;isomerase activity alcohol metabolic process;amino sugar metabolic process;carbohydrate metabolic process;glucosamine catabolic process;glucosamine metabolic process;monosaccharide metabolic process;N-acetylglucosamine metabolic process Aminosugars metabolism 15 15 8 61.6 61.6 32.5 32.668 5.4178E-237 744070000 406820000 337250000 773 IPI:IPI00009305.1 Glucosamine-6-phosphate isomerase 1;Glucosamine-6-phosphate deaminase 1;Oscillin GNPDA1;GNPI;HLN;KIAA0060 P46926 ENST00000311337 K02564 1 1.3203 2.5072 1.3834 1.6964 1.6193 1.7194 ACBP cytoplasmic part;Golgi apparatus part;Golgi membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;mitochondrion;organelle;organelle membrane;organelle part acyl-CoA binding;binding;carboxylic acid binding;coenzyme binding;cofactor binding;fatty acid binding;lipid binding;monocarboxylic acid binding;protein binding biosynthetic process;cellular biosynthetic process;cellular metabolic process;cellular process;lipid biosynthetic process;lipid metabolic process;metabolic process;primary metabolic process;steroid biosynthetic process;steroid metabolic process 10 10 10 25.4 25.4 25.4 60.593 0 189200000 86796000 102410000 774 IPI:IPI00009315.6 Golgi resident protein GCP60;Acyl-CoA-binding domain-containing protein 3;Golgi phosphoprotein 1;Golgi complex-associated protein 1;PBR- and PKA-associated protein 7;Peripheral benzodiazepine receptor-associated protein PAP7 ACBD3;GCP60;GOCAP1;GOLPH1 Q9H3P7 ENST00000366812 1 0.89327 1.6449 0.90355 1.1695 0.95041 1.1877 Pro_isomerase;RRM_1 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;catalytic activity;cis-trans isomerase activity;cyclosporin A binding;drug binding;isomerase activity;nucleic acid binding;nucleotide binding;peptide binding;peptidyl-prolyl cis-trans isomerase activity;protein binding;RNA binding cellular process;metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein folding;regulation of biosynthetic process;RNA processing;RNA splicing 9 9 8 40.5 40.5 38.2 33.43 5.8604E-30 165530000 82043000 83490000 775 IPI:IPI00009316.3;IPI:IPI00220188.1 Peptidyl-prolyl cis-trans isomerase E;Cyclophilin E;Cyclophilin-33 PPIE;CYP33 Q9UNP9-1;Q9UNP9;Q9UNP9-2 ENST00000324379;ENST00000356511;ENST00000372834 K09564 2 0.59244 1.406 0.81957 0.77752 0.94117 1.197 DUF2013;SH3_1 cell part;cytoskeletal part;intermediate filament;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;nucleus;organelle;organelle part binding;cytoskeletal protein binding;protein binding;protein domain specific binding;SH3 domain binding cell communication;cytoskeleton organization;intracellular protein transport;NLS-bearing substrate import into nucleus;nucleocytoplasmic transport;organelle organization;protein import into nucleus;protein targeting;signal transduction;transport 4 4 4 8.9 8.9 8.9 78.959 2.0477E-16 11975000 5888600 6086200 776 IPI:IPI00009319.1;IPI:IPI00218563.1 NCK-interacting protein with SH3 domain;SH3 adapter protein SPIN90;SH3 protein interacting with Nck, 90 kDa;VacA-interacting protein, 54 kDa;AF3p21;Diaphanous protein-interacting protein;Dia-interacting protein 1 NCKIPSD;AF3P21;SPIN90 Q9NZQ3-1;Q9NZQ3;Q9NZQ3-2 ENST00000294129;ENST00000341520 2 0.91515 1.4013 NaN 1.1345 0.97809 NaN DUF1077 cell part;integral to membrane;intrinsic to membrane;membrane part 2 2 1 10.9 10.9 5.5 20.086 1.6119E-13 1181800 662620 519200 777 IPI:IPI00009320.3;IPI:IPI00031499.2 Transmembrane protein 85;Cell proliferation-inducing gene 17 protein TMEM85;HSPC184;PIG17 Q5J8M3-1;Q5J8M3;Q5J8M3-2 ENST00000249209;ENST00000267750 2 0.75647 1.3072 0.74282 0.97033 0.88659 0.93737 DEAD;Helicase_C cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex ATP-dependent RNA helicase activity;binding;catalytic activity;helicase activity;mRNA binding;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;RNA binding;RNA helicase activity;single-stranded RNA binding mRNA processing;nuclear-transcribed mRNA catabolic process;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA catabolic process;RNA processing;rRNA processing 32 27 27 66.4 60.3 60.3 46.871 0 4191400000 2144100000 2047200000 779 IPI:IPI00009328.4 Eukaryotic initiation factor 4A-III;Eukaryotic translation initiation factor 4A isoform 3;ATP-dependent RNA helicase eIF4A-3;ATP-dependent RNA helicase DDX48;DEAD box protein 48;Eukaryotic initiation factor 4A-like NUK-34;Nuclear matrix protein 265 EIF4A3;DDX48;KIAA0111 P38919 ENST00000269349 K03257 1 0.77012 1.6213 0.66022 1.0752 0.96377 0.94416 CH;efhand_1;efhand_2;Spectrin;WW;ZZ cell fraction;cell junction;cytoplasm;cytoskeleton;insoluble fraction;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane fraction;membrane part;non-membrane-bounded organelle;organelle;synapse part actin binding;binding;calcium ion binding;cation binding;cytoskeletal protein binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding anatomical structure development;developmental process;multicellular organismal process;muscle contraction;muscle organ development;muscle system process;organ development;system process 7 7 7 2.2 2.2 2.2 394.46 3.8486E-24 72176000 40120000 32056000 780 IPI:IPI00009329.2 Utrophin;Dystrophin-related protein 1 UTRN;DMDL P46939 ENST00000367545 1 0.55772 1.0746 0.48283 0.69207 0.74634 0.60278 DUF383;DUF384 binding 10 10 10 29.2 29.2 29.2 42.128 3.4773E-36 239810000 133480000 106320000 782 IPI:IPI00741734.2;IPI:IPI00009335.2 Brain protein 16 BRP16;C8orf30A P0CB43;Q9BTY7 ENST00000347708 2 0.7954 1.6704 0.81293 1.0565 1.0999 1.0733 CH;IQ;RasGAP;RasGAP_C;WW actin filament;cell part;cytoskeletal part;intracellular organelle part;intracellular part;membrane;organelle part;plasma membrane binding;calmodulin binding;enzyme activator activity;enzyme binding;enzyme inhibitor activity;GTPase activator activity;GTPase inhibitor activity;phosphatase binding;protein binding;Ras GTPase activator activity;small GTPase regulator activity cell communication;cellular process;intracellular signaling cascade;regulation of biological process;regulation of cell communication;regulation of signal transduction;signal transduction;small GTPase mediated signal transduction Regulation of actin cytoskeleton 57 57 55 36 36 35.1 189.25 0 5002100000 2617600000 2384500000 783 IPI:IPI00009342.1;IPI:IPI00328905.6 Ras GTPase-activating-like protein IQGAP1;p195 IQGAP1;KIAA0051 P46940 ENST00000268182 K05767 2 0.93932 1.1664 NaN 1.2569 0.77859 NaN PARP;zf-CCCH cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;cation binding;ion binding;NAD+ ADP-ribosyltransferase activity;nucleic acid binding;transferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring pentosyl groups;zinc ion binding 8 7 7 11.7 10.6 10.6 79.063 3.7813E-22 13707000 6900300 6806900 784 IPI:IPI00009355.1 Poly [ADP-ribose] polymerase 12;Zinc finger CCCH domain-containing protein 1 PARP12;ZC3HDC1 Q9H0J9 ENST00000263549 1 0.58097 1.0732 0.62016 0.72007 0.73774 0.75705 ORMDL cell part;cytoplasmic part;endoplasmic reticulum;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part 3 1 1 21.6 9.8 9.8 17.371 2.8478E-39 37535000 20229000 17307000 785 IPI:IPI00009364.3;IPI:IPI00171701.4 ORM1-like protein 1;Adoplin-1;ORM1-like protein 2;Adoplin-2 ORMDL1;HSPC202;ORMDL2;HSPC160;MSTP095 Q9P0S3;Q53FV1 ENST00000325795;ENST00000392349;ENST00000392350;ENST00000243045 2 0.80034 1.4412 0.80256 0.9767 1.0406 0.96993 Mtc cell part;integral to membrane;intrinsic to membrane;membrane part binding;cation transmembrane transporter activity;ion transmembrane transporter activity;iron ion binding;protein binding;substrate-specific transmembrane transporter activity;transmembrane transporter activity;transporter activity cation transport;di-, tri-valent inorganic cation transport;establishment of localization;ion transport;iron ion transport;metal ion transport;transition metal ion transport;transport 14 14 14 56.8 56.8 56.8 35.619 1.249E-188 2051100000 1074000000 977050000 786 IPI:IPI00009368.4 Sideroflexin-1;Tricarboxylate carrier protein SFXN1 Q9H9B4 ENST00000321442 1 0.73842 1.7829 0.82959 1.001 1.1113 1.1174 DUF727 cell part;cytoplasm;intracellular part binding;protein binding 2 2 2 23 23 23 15.648 3.6482E-15 21925000 12020000 9905400 787 IPI:IPI00009374.4 GSK3-beta interaction protein GSKIP;C14orf129;HSPC210 Q9P0R6 ENST00000329856 1 NaN 1.5962 NaN NaN 1.0408 NaN R3H cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;DNA binding;DNA helicase activity;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;single-stranded DNA binding;zinc ion binding DNA metabolic process;DNA recombination;DNA repair;DNA replication;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;response to stress;transcription 2 2 2 2.7 2.7 2.7 109.12 8.1918E-07 3172700 1670700 1502000 788 IPI:IPI00009379.2 DNA-binding protein SMUBP-2;ATP-dependent helicase IGHMBP2;Immunoglobulin mu-binding protein 2;Glial factor 1 IGHMBP2;SMBP2;SMUBP2 P38935 ENST00000255078 1 0.87525 1.7477 0.97344 1.0865 1.2184 1.2083 DAD cell part;cytoplasmic part;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;macromolecular complex;membrane part;oligosaccharyltransferase complex;organelle part;protein complex catalytic activity;dolichyl-diphosphooligosaccharide-protein glycotransferase activity;oligosaccharyl transferase activity;transferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring hexosyl groups anti-apoptosis;apoptosis;carbohydrate metabolic process;cell death;cellular process;metabolic process;programmed cell death;protein amino acid glycosylation;protein amino acid N-linked glycosylation;protein modification process;regulation of cell death N-Glycan biosynthesis 3 3 3 28.3 28.3 28.3 12.497 2.0186E-38 387400000 196790000 190620000 789 IPI:IPI00009407.8 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1;Defender against cell death 1 DAD1 P61803 ENST00000250498 K00730 1 0.81348 3.1943 0.63312 1.0809 2.0031 0.84386 Glyco_hydro_47;PA endoplasmic reticulum;endoplasmic reticulum lumen;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;membrane-enclosed lumen;organelle;organelle lumen;organelle part binding;calcium ion binding;catalytic activity;hydrolase activity;hydrolase activity, hydrolyzing O-glycosyl compounds;mannosidase activity;mannosyl-oligosaccharide 1,2-alpha-mannosidase activity;mannosyl-oligosaccharide mannosidase activity response to biotic stimulus;response to chemical stimulus;response to organic substance;response to protein stimulus;response to stimulus;response to stress;response to unfolded protein 3 3 3 3.6 3.6 3.6 104.66 3.1136E-05 958000 529380 428620 790 IPI:IPI00009410.2 ER degradation-enhancing alpha-mannosidase-like 3 EDEM3;C1orf22 Q9BZQ6 ENST00000318130 K10086 1 0.77481 1.3772 0.94032 0.99364 0.94029 1.1574 Ribosomal_L27 cytoplasmic part;intracellular part;large ribosomal subunit;macromolecular complex;mitochondrial large ribosomal subunit;mitochondrial part;organellar large ribosomal subunit;organelle part;ribonucleoprotein complex;ribosomal subunit structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 6 6 6 41.9 41.9 41.9 16.073 7.1647E-113 65304000 35902000 29402000 791 IPI:IPI00009444.3 39S ribosomal protein L27, mitochondrial;L27mt;MRP-L27 MRPL27;HSPC250 Q9P0M9 ENST00000225969;ENST00000393275 1 NaN 1.6694 0.099179 NaN 1.1769 0.1265 OTU;zf-A20 centrosome;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;microtubule organizing center;non-membrane-bounded organelle;nucleus;organelle;organelle part binding;catalytic activity;cation binding;cysteine-type peptidase activity;DNA binding;hydrolase activity;ion binding;metal ion binding;nucleic acid binding;peptidase activity;protein binding;transition metal ion binding;zinc ion binding anti-apoptosis;apoptosis;catabolic process;cell death;cellular process;macromolecule catabolic process;metabolic process;negative regulation of signal transduction;proteolysis;regulation of protein kinase cascade;regulation of signal transduction 4 4 4 6.5 6.5 6.5 89.613 1.853E-34 6729400 5439900 1289500 792 IPI:IPI00009448.1 Tumor necrosis factor, alpha-induced protein 3;Putative DNA-binding protein A20;Zinc finger protein A20 TNFAIP3 P21580 ENST00000237289 K11859 1 0.63101 1.246 0.68737 0.86796 0.8249 0.91084 3_5_exonuc;HRDC;PMC2NT cytoplasm;exosome (RNase complex);intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nuclear exosome (RNase complex);nucleolus;organelle;organelle part;protein complex 3'-5' exonuclease activity;binding;catalytic activity;exonuclease activity;kinase activity;nuclease activity;nucleic acid binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;RNA binding;transferase activity nuclear-transcribed mRNA catabolic process;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA catabolic process;RNA processing;rRNA processing 18 18 18 26.7 26.7 26.7 100.83 1.6605E-185 254660000 133690000 120960000 793 IPI:IPI00009464.1;IPI:IPI00220336.1 Exosome component 10;Polymyositis/scleroderma autoantigen 2;Autoantigen PM/Scl 2;Polymyositis/scleroderma autoantigen 100 kDa;P100 polymyositis-scleroderma overlap syndrome-associated autoantigen EXOSC10;PMSCL;PMSCL2 Q01780-1;Q01780;Q01780-2 ENST00000304457;ENST00000376936 2 0.43611 0.93517 0.46911 0.58679 0.61724 0.59743 Utp12;WD40 intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;preribosome;ribonucleoprotein complex;small-subunit processome cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 22 22 22 26.9 26.9 26.9 106.1 2.8773E-204 317090000 172750000 144330000 794 IPI:IPI00009471.1 WD repeat-containing protein 3 WDR3 Q9UNX4 ENST00000349139 1 0.70693 1.3474 0.73596 0.95823 0.84579 0.99648 ICAM_N cell part;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part binding;integrin binding;protein binding;protein complex binding;receptor binding biological adhesion;cell adhesion;cell-cell adhesion;cellular process Cell adhesion molecules (CAMs);Natural killer cell mediated cytotoxicity 3 3 3 14.9 14.9 14.9 30.654 1.5337E-105 51070000 27726000 23344000 795 IPI:IPI00009477.4 Intercellular adhesion molecule 2 ICAM2 P13598 ENST00000225760 K06523 1 0.59303 1.7618 0.49402 0.74612 1.2402 0.62388 PCI_Csn8 cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex;signalosome 3 3 3 29.7 29.7 29.7 23.225 8.894E-81 26098000 16617000 9480900 796 IPI:IPI00009480.1 COP9 signalosome complex subunit 8;JAB1-containing signalosome subunit 8;COP9 homolog COPS8;CSN8 Q99627 ENST00000354371 K12181 1 0.76966 1.428 0.74747 0.97037 1.0031 0.9427 PDZ;PH cell fraction;cell junction;cytoplasmic vesicle membrane;dystrophin-associated glycoprotein complex;insoluble fraction;macromolecular complex;membrane;membrane fraction;microtubule;organelle membrane;secretory granule membrane;vesicle membrane actin binding;binding;calcium ion binding;calmodulin binding;cation binding;cytoskeletal protein binding;ion binding;metal ion binding;protein binding 3 3 3 6.1 6.1 6.1 57.949 2.1622E-05 6921700 3728500 3193200 797 IPI:IPI00009505.1;IPI:IPI00216631.1 Beta-2-syntrophin;59 kDa dystrophin-associated protein A1 basic component 2;Syntrophin-3;Syntrophin-like SNTB2;D16S2531E;SNT2B2;SNTL Q13425-1;Q13425;Q13425-2 ENST00000336278;ENST00000360496 2 0.8679 2.8646 NaN 1.1718 1.8328 NaN Aminotran_3 4-aminobutyrate transaminase complex;cell part;cytoplasmic part;intracellular organelle part;intracellular part;macromolecular complex;mitochondrial matrix;mitochondrial part;organelle part;protein complex 4-aminobutyrate transaminase activity;binding;catalytic activity;enzyme binding;lipid binding;protein binding;steroid binding;transaminase activity;transferase activity;transferase activity, transferring nitrogenous groups;vitamin binding cellular amino acid and derivative metabolic process;cellular amino acid derivative metabolic process;fatty acid metabolic process;lipid metabolic process;organic acid metabolic process;regulation of neurotransmitter levels Alanine and aspartate metabolism;beta-Alanine metabolism;Butanoate metabolism;Glutamate metabolism;Propanoate metabolism;Valine, leucine and isoleucine degradation 4 4 4 10.5 10.5 10.5 58.228 6.0955E-52 3889200 2371700 1517500 798 IPI:IPI00009532.5 4-aminobutyrate aminotransferase, mitochondrial;Gamma-amino-N-butyrate transaminase;GABA aminotransferase;L-AIBAT;(S)-3-amino-2-methylpropionate transaminase ABAT;GABAT P80404 ENST00000268251;ENST00000396600 K00823;K07250 1 1.0165 1.5939 1.0919 1.3197 1.0866 1.4195 MAGE 12 12 10 15.2 15.2 13.7 64.953 3.8652E-96 211400000 102720000 108680000 800 IPI:IPI00009542.1;IPI:IPI00337823.1 Melanoma-associated antigen D2;MAGE-D2 antigen;Breast cancer-associated gene 1 protein;11B6;Hepatocellular carcinoma-associated protein JCL-1 MAGED2;BCG1 Q9UNF1-1;Q9UNF1;Q9UNF1-2 ENST00000218439;ENST00000343474;ENST00000375053;ENST00000375058;ENST00000375068;ENST00000396224 2 0.88225 1.9862 NaN 1.1719 1.3194 NaN RhoGAP cell part;intracellular;membrane binding;catalytic activity;enzyme activator activity;GTPase activator activity;hydrolase activity;protein binding;pyrophosphatase activity;Ras GTPase activator activity;Rho GTPase activator activity;small GTPase regulator activity behavior;cell communication;cellular process;chemotaxis;intracellular signaling cascade;locomotory behavior;regulation of Ras GTPase activity;response to external stimulus;signal transduction;small GTPase mediated signal transduction;transport Pancreatic cancer;Pathways in cancer 6 6 6 11 11 11 76.063 6.3638E-13 40372000 21170000 19202000 801 IPI:IPI00009544.3 RalA-binding protein 1;Ral-interacting protein 1;76 kDa Ral-interacting protein;Dinitrophenyl S-glutathione ATPase RALBP1;RLIP1;RLIP76 Q15311 ENST00000019317;ENST00000383432 K08773 1 1.6509 3.2785 1.7392 2.2228 2.1376 2.3599 Pyr_redox_2 catalytic activity;oxidoreductase activity metabolic process;oxidation reduction 11 11 11 28.7 28.7 28.7 49.96 7.4017E-152 42146000 19945000 22201000 803 IPI:IPI00009634.1 Sulfide:quinone oxidoreductase, mitochondrial SQRDL;CGI-44 Q9Y6N5 ENST00000260324 K00540 1 0.55501 0.99181 0.57529 0.68563 0.65963 0.72834 zf-C2H2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 17 17 17 31.7 31.7 31.7 88.475 5.8748E-261 254200000 137770000 116430000 804 IPI:IPI00009646.1;IPI:IPI00009213.1;IPI:IPI00300332.4;IPI:IPI00400871.1 B-cell lymphoma/leukemia 11B;B-cell CLL/lymphoma 11B;Radiation-induced tumor suppressor gene 1 protein;COUP-TF-interacting protein 2 BCL11B;CTIP2;RIT1 Q9C0K0-2;Q9C0K0;Q9C0K0-1 ENST00000357195 4 NaN 12.251 0.15891 NaN 8.7748 0.19379 Lipocalin extracellular region binding;cysteine-type endopeptidase inhibitor activity;endopeptidase inhibitor activity;enzyme inhibitor activity;enzyme regulator activity;peptidase inhibitor activity;protein binding;transporter activity catabolic process;macromolecule catabolic process;metabolic process;multicellular organismal process;protein catabolic process;protein metabolic process;proteolysis;sensory perception;sensory perception of chemical stimulus;system process;transport 2 2 1 12.5 12.5 6.2 19.25 4.6001E-11 38606000 37467000 1139300 805 IPI:IPI00009650.1 Lipocalin-1;Von Ebner gland protein;Tear prealbumin;Tear lipocalin LCN1;VEGP P31025 ENST00000263598;ENST00000371781 1 0.83539 1.3232 1.0096 1.0127 0.86155 1.262 Sybindin cell part;cytoplasmic part;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle cellular process;ER to Golgi vesicle-mediated transport;establishment of localization;establishment of localization in cell;Golgi vesicle transport;intracellular transport;transport;vesicle-mediated transport 4 4 4 33.8 33.8 33.8 16.831 1.8069E-153 36040000 16847000 19193000 806 IPI:IPI00009654.1 Trafficking protein particle complex subunit 1;BET5 homolog;Multiple myeloma protein 2 TRAPPC1;BET5;MUM2 Q9Y5R8 ENST00000303731 1 0.86732 1.7097 0.89668 1.1318 1.1446 1.0771 DUF618 9 9 7 28.8 28.8 23.9 36.899 1.4028E-179 235040000 118860000 116180000 807 IPI:IPI00009659.3 Regulation of nuclear pre-mRNA domain-containing protein 1B;Cell cycle-related and expression-elevated protein in tumor RPRD1B;C20orf77;CREPT Q9NQG5 ENST00000373433 1 0.38733 0.78667 0.45586 0.50484 0.50552 0.60036 CENP-H condensed chromosome kinetochore;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;kinetochore;macromolecular complex;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle binding;kinetochore binding;protein binding cell division;cellular component organization;cellular macromolecular complex subunit organization;cellular process;chromosome organization;chromosome segregation;kinetochore organization;macromolecular complex subunit organization;organelle organization 3 3 3 13 13 13 28.481 7.5841E-114 28969000 17124000 11845000 808 IPI:IPI00009668.3 Centromere protein H;Interphase centromere complex protein 35 CENPH;ICEN35 Q9H3R5 ENST00000283006 K11500 1 0.6689 1.4992 0.66279 0.91683 0.96833 0.90079 Ribonuclease_3 intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;mitochondrion;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome binding;catalytic activity;double-stranded RNA binding;endonuclease activity;endoribonuclease activity;hydrolase activity;nuclease activity;nucleic acid binding;protein binding;ribonuclease activity;ribonuclease III activity;RNA binding cellular biopolymer metabolic process;cellular process;macromolecule metabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing 9 9 9 32.2 32.2 32.2 37.535 1.8219E-150 147960000 78197000 69759000 809 IPI:IPI00009680.3 39S ribosomal protein L44, mitochondrial;MRP-L44 MRPL44 Q9H9J2 ENST00000258383 1 0.79322 1.6536 0.80073 1.0389 1.0857 1.0412 PIP5K ATP binding;binding;catalytic activity;inositol or phosphatidylinositol kinase activity;kinase activity;lipid kinase activity;nucleoside binding;nucleotide binding;phosphatidylinositol phosphate kinase activity;purine nucleoside binding cellular process;glycerophospholipid metabolic process;lipid metabolic process;metabolic process;organophosphate metabolic process;phosphate metabolic process;phospholipid metabolic process;phosphorus metabolic process;phosphorylation Inositol phosphate metabolism;Phosphatidylinositol signaling system;Regulation of actin cytoskeleton 15 15 11 35.2 35.2 28.1 46.224 0 253610000 99305000 154310000 810 IPI:IPI00009688.1 Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha;Phosphatidylinositol-5-phosphate 4-kinase type II alpha;1-phosphatidylinositol-5-phosphate 4-kinase 2-alpha;PtdIns(5)P-4-kinase isoform 2-alpha;Diphosphoinositide kinase 2-alpha;PtdIns(4)P-5-kinase B isoform;PIP5KIII;PtdIns(4)P-5-kinase C isoform PIP4K2A;PIP5K2;PIP5K2A P48426 ENST00000376573 K00920 1 NaN 1.111 NaN NaN 0.78309 NaN 3 3 3 4.7 4.7 4.7 85.638 1.2569E-09 9086100 5132100 3954000 811 IPI:IPI00550977.1;IPI:IPI00009702.4;IPI:IPI00847495.1 Coiled-coil domain-containing protein 21 CCDC21 Q6P2H3-1;Q6P2H3;Q6P2H3-2 ENST00000252992 3 0.70873 1.3303 0.77634 0.90531 0.95393 0.97927 3 3 3 11 11 11 43.992 5.1593E-12 30479000 15793000 14686000 812 IPI:IPI00009707.5;IPI:IPI00554550.2 Protein RMD5 homolog A RMND5A Q9H871-1;Q9H871 ENST00000283632;ENST00000393767 2 0.7335 1.7389 0.76562 0.97621 1.2142 1.0159 CTP_transf_2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;magnesium ion binding;nicotinamide-nucleotide adenylyltransferase activity;nicotinate-nucleotide adenylyltransferase activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding coenzyme metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;oxidoreduction coenzyme metabolic process;vitamin metabolic process;water-soluble vitamin metabolic process Nicotinate and nicotinamide metabolism 3 3 3 17.6 17.6 17.6 31.932 4.4441E-18 38639000 20235000 18404000 813 IPI:IPI00009726.4 Nicotinamide mononucleotide adenylyltransferase 1;Nicotinate-nucleotide adenylyltransferase 1 NMNAT1;NMNAT Q9HAN9 ENST00000377205 K00952 1 0.15288 0.68237 0.62876 0.20225 0.4558 0.75744 Spot_14 cell part;cytoplasm;cytoskeletal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;microtubule;nucleus;organelle;organelle part negative regulation of macromolecule metabolic process;negative regulation of metabolic process;negative regulation of microtubule depolymerization;negative regulation of organelle organization;regulation of metabolic process 4 4 4 26.2 26.2 26.2 20.201 4.3222E-48 54674000 32782000 21892000 814 IPI:IPI00009730.1 Mid1-interacting protein 1;Gastrulation-specific G12-like protein;Mid1-interacting G12-like protein;Protein STRAIT11499 MID1IP1;MIG12 Q9NPA3 ENST00000336949;ENST00000378474 1 0.90997 1.7538 0.82873 1.2235 1.1179 1.1097 Gtr1_RagA cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;protein binding;protein dimerization activity;protein heterodimerization activity;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding 7 7 1 18.8 18.8 2.2 45.587 4.4871E-44 54737000 30509000 24229000 815 IPI:IPI00009737.1;IPI:IPI00478668.3 Ras-related GTP-binding protein D RRAGD Q9NQL2-1;Q9NQL2;Q9NQL2-2 ENST00000369415 2 0.72856 1.2689 0.71242 0.90745 0.84626 0.88021 Prenyltrans catalytic activity;intramolecular transferase activity;isomerase activity;lanosterol synthase activity;oxidosqualene cyclase activity alcohol metabolic process;biosynthetic process;cellular process;cholesterol biosynthetic process;cholesterol metabolic process;lipid biosynthetic process;lipid metabolic process;metabolic process;steroid biosynthetic process;steroid metabolic process Biosynthesis of steroids 25 25 25 39.3 39.3 39.3 83.308 3.0082E-194 844740000 441170000 403570000 817 IPI:IPI00009747.1 Lanosterol synthase;Oxidosqualene--lanosterol cyclase;2,3-epoxysqualene--lanosterol cyclase LSS;OSC P48449 ENST00000356396;ENST00000397728 K01852 1 NaN NaN 0.85819 NaN NaN 1.1341 Pellino binding;protein binding 2 2 2 5.7 5.7 5.7 46.435 0.0033 19451000 9412000 10039000 818 IPI:IPI00009753.1 Protein pellino homolog 2 PELI2 Q9HAT8 ENST00000267460 K11965 1 0.47504 0.97597 NaN 0.67352 0.60914 NaN MT-A70 cell part;intracellular organelle part;intracellular part;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part binding;catalytic activity;methyltransferase activity;mRNA methyltransferase activity;nucleic acid binding;RNA binding;RNA methyltransferase activity;S-adenosylmethionine-dependent methyltransferase activity cellular process;metabolic process;methylation;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;one-carbon metabolic process;RNA metabolic process;RNA methylation;RNA modification 8 8 8 14 14 14 64.473 1.5059E-27 28342000 15068000 13274000 819 IPI:IPI00009755.3;IPI:IPI00328636.1 N6-adenosine-methyltransferase 70 kDa subunit;Methyltransferase-like protein 3 METTL3;MTA70 Q86U44-1;Q86U44 ENST00000298717 K05925 2 0.67424 1.4557 0.63891 0.90588 0.957 0.86569 PFK 6-phosphofructokinase complex;cell part;cytoplasmic part;cytosolic part;intracellular part;macromolecular complex;protein complex 6-phosphofructokinase activity;ATP binding;binding;catalytic activity;kinase activity;magnesium ion binding;nucleoside binding;nucleotide binding;phosphofructokinase activity;protein binding;purine nucleoside binding;transferase activity alcohol metabolic process;carbohydrate metabolic process;catabolic process;cellular process;generation of precursor metabolites and energy;glucose catabolic process;glucose metabolic process;glycolysis;metabolic process;monosaccharide metabolic process Fructose and mannose metabolism;Galactose metabolism;Glycolysis / Gluconeogenesis;Pentose phosphate pathway 40 40 36 53.7 53.7 48 85.595 0 4174900000 2292600000 1882300000 820 IPI:IPI00009790.1;IPI:IPI00743142.2;IPI:IPI00219585.4 6-phosphofructokinase type C;Phosphofructokinase 1;Phosphohexokinase;Phosphofructo-1-kinase isozyme C;6-phosphofructokinase, platelet type PFKP;PFKF Q01813 ENST00000381125 K00850 3 0.50721 0.89666 0.50442 0.67117 0.6064 0.63259 FG-GAP;Integrin_alpha;Integrin_alpha2 cell part;cell surface;integrin complex;macromolecular complex;membrane part;plasma membrane part;protein complex;receptor complex binding;calcium ion binding;cation binding;identical protein binding;ion binding;metal ion binding;molecular transducer activity;protein binding;receptor activity;signal transducer activity cell activation;cell adhesion;cell communication;cell surface receptor linked signal transduction;cellular process;immune system process;integrin-mediated signaling pathway;leukocyte adhesion;leukocyte differentiation;signal transduction Cell adhesion molecules (CAMs);ECM-receptor interaction;Focal adhesion;Hematopoietic cell lineage;Leukocyte transendothelial migration;Regulation of actin cytoskeleton 19 19 19 20.4 20.4 20.4 115.33 3.1597E-143 586010000 318890000 267110000 821 IPI:IPI00009803.1 Integrin alpha-4;Integrin alpha-IV;VLA-4;CD49 antigen-like family member D ITGA4;CD49D P13612 ENST00000233573;ENST00000397033 K06483 1 0.55796 0.84304 0.54131 0.73664 0.5606 0.70573 CUT;Homeobox cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;double-stranded DNA binding;nucleic acid binding;sequence-specific DNA binding;structure-specific DNA binding;transcription factor activity;transcription regulator activity chromatin organization;negative regulation of transcription from RNA polymerase II promoter;organelle organization;regulation of biosynthetic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent 17 17 17 31.3 31.3 31.3 89.126 3.5259E-98 624070000 335000000 289070000 822 IPI:IPI00555719.2;IPI:IPI00009804.1;IPI:IPI00010433.3 DNA-binding protein SATB1;Special AT-rich sequence-binding protein 1 SATB1 Q01826-2;Q01826;Q01826-1 ENST00000332610;ENST00000338745 3 0.55709 1.2798 0.67936 0.68996 0.90403 0.87279 TBPIP cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;protein binding cell cycle phase;cell cycle process;cellular process;DNA metabolic process;DNA recombination;meiosis;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2 2 2 13.4 13.4 13.4 24.906 1.0177E-44 24702000 13276000 11427000 823 IPI:IPI00009805.3;IPI:IPI00335760.4 Homologous-pairing protein 2 homolog;Proteasome 26S ATPase subunit 3-interacting protein;PSMC3-interacting protein;Tat-binding protein 1-interacting protein;Nuclear receptor coactivator GT198 PSMC3IP;HOP2;TBPIP Q9P2W1-1;Q9P2W1;Q9P2W1-2 ENST00000253789 K06695 2 0.78724 1.7003 0.87048 1.0446 1.0984 1.1938 SRP_SPB;SRP54;SRP54_N cytoplasmic part;intracellular organelle part;intracellular part;macromolecular complex;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part;ribonucleoprotein complex;signal recognition particle, endoplasmic reticulum targeting 7S RNA binding;binding;catalytic activity;GTP binding;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleic acid binding;nucleotide binding;protein binding;pyrophosphatase activity;RNA binding cotranslational protein targeting to membrane;intracellular protein transport;protein targeting;protein targeting to ER;protein targeting to membrane;protein transport;SRP-dependent cotranslational protein targeting to membrane;transport Bacterial secretion system;Protein export 17 17 17 36.3 36.3 36.3 55.704 0 417780000 221220000 196570000 825 IPI:IPI00009822.1 Signal recognition particle 54 kDa protein SRP54 P61011 ENST00000216774 K03106 1 0.76754 1.5491 0.78191 0.99707 1.0412 0.9804 IMPDH alkali metal ion binding;binding;catalytic activity;GMP reductase activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor;potassium ion binding cellular metabolic process;cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;nucleotide metabolic process Purine metabolism 10 10 10 37.1 37.1 37.1 37.874 4.9061E-186 141520000 76902000 64617000 826 IPI:IPI00009844.1;IPI:IPI00304803.3 GMP reductase 2;Guanosine 5'-monophosphate oxidoreductase 2 GMPR2 Q9P2T1 ENST00000355299;ENST00000399440 K00364 2 0.64541 1.4741 0.64285 0.88215 0.92253 0.85588 FKBP_C cell part;integral to membrane;intrinsic to membrane;membrane part catalytic activity;cis-trans isomerase activity;isomerase activity;peptidyl-prolyl cis-trans isomerase activity biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 2 2 2 14.4 14.4 14.4 22.18 1.8557E-54 104850000 56563000 48292000 829 IPI:IPI00009885.1 FK506-binding protein 11;Peptidyl-prolyl cis-trans isomerase;19 kDa FK506-binding protein;FKBP-19 FKBP11;FKBP19;UNQ336/PRO535 Q9NYL4 ENST00000256680 K09576 1 0.87224 1.8615 0.821 1.1447 1.1432 1.1403 Abhydrolase_1;EHN cell fraction;endoplasmic reticulum membrane;insoluble fraction;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane fraction;membrane part;microsome;organelle membrane;organelle part;vesicular fraction catalytic activity;cis-stilbene-oxide hydrolase activity;epoxide hydrolase activity;ether hydrolase activity;hydrolase activity;hydrolase activity, acting on ether bonds aromatic compound catabolic process;catabolic process;cellular aromatic compound metabolic process;cellular catabolic process;cellular metabolic process;cellular process;metabolic process;response to chemical stimulus;response to toxin Metabolism of xenobiotics by cytochrome P450 10 10 10 27 27 27 52.948 4.8999E-100 109240000 57884000 51356000 830 IPI:IPI00009896.1 Epoxide hydrolase 1;Microsomal epoxide hydrolase;Epoxide hydratase EPHX1;EPHX;EPOX P07099 ENST00000272167;ENST00000366837 K01253 1 0.9251 1.6952 0.82504 1.1828 1.1949 1.0504 NTF2 cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;organelle part;pore complex;protein complex binding;protein binding 4 4 4 35.4 35.4 35.4 14.478 6.508E-107 199300000 103410000 95889000 831 IPI:IPI00009901.1 Nuclear transport factor 2;Placental protein 15 NUTF2;NTF2 P61970 ENST00000219169 1 1.0518 2.2522 1.0003 1.4206 1.4126 1.3678 Thioredoxin cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;endoplasmic reticulum;endoplasmic reticulum lumen;intracellular organelle;melanosome;membrane-bounded organelle;membrane-bounded vesicle;membrane-enclosed lumen;organelle;vesicle binding;catalytic activity;intramolecular oxidoreductase activity;intramolecular oxidoreductase activity, interconverting keto- and enol-groups;isomerase activity;protein binding;protein disulfide isomerase activity cell redox homeostasis;cellular homeostasis;cellular process;establishment of protein localization;homeostatic process;protein secretion;protein transport;regulation of biological process;secretion;secretion by cell;transport Vibrio cholerae infection 34 34 34 47.1 47.1 47.1 72.932 0 3133000000 1649600000 1483400000 832 IPI:IPI00009904.1 Protein disulfide-isomerase A4;Protein ERp-72 PDIA4;ERP70;ERP72 P13667 ENST00000286091 K09582 1 0.7764 1.8898 1.1554 1.0591 1.178 1.4778 DUF634 cytoplasm;cytoskeleton;integral to membrane;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intrinsic to membrane;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle binding 5 5 5 15.6 15.6 15.6 42.5 2.4343E-07 43709000 6295400 37414000 833 IPI:IPI00009906.5 Armadillo repeat-containing X-linked protein 3;ARM protein lost in epithelial cancers on chromosome X 3 ARMCX3;ALEX3;BM-017;UNQ2517/PRO6007 Q9UH62 ENST00000341189;ENST00000395122;ENST00000407856 1 NaN 0.54106 0.61436 NaN 0.34182 0.83109 Exo_endo_phos cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding;transcription cofactor activity;transcription corepressor activity;transcription factor binding;transcription regulator activity;transcription repressor activity biological regulation;cell communication;cell surface receptor linked signal transduction;cellular process;regulation of biological process;regulation of cellular process;signal transduction 3 3 3 9.9 9.9 9.9 44.338 4.4539E-06 23280000 13101000 10179000 834 IPI:IPI00954485.1;IPI:IPI00009913.8;IPI:IPI00954580.1 TRAF and TNF receptor-associated protein;ETS1-associated protein 2;ETS1-associated protein II TTRAP;EAP2;AD-022 O95551-2;O95551;O95551-1;O95551-3 ENST00000378198 3 0.81757 1.516 0.85849 1.0638 1.0015 1.1036 RRM_1 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;nucleus;organelle binding;nucleic acid binding;nucleotide binding;RNA binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 7 7 7 67 67 67 12.349 8.9507E-104 1660500000 849950000 810530000 835 IPI:IPI00009922.3 SRA stem-loop-interacting RNA-binding protein, mitochondrial SLIRP;C14orf156;DC23;DC50;PD04872 Q9GZT3 ENST00000238688 1 NaN 1.8727 0.71575 NaN 1.328 0.87308 Hydrolase catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;phosphatase activity;phosphoglycolate phosphatase activity;phosphoric ester hydrolase activity metabolic process 4 4 4 21.5 21.5 21.5 28 3.578E-11 14155000 8084100 6071300 836 IPI:IPI00009931.3 Haloacid dehalogenase-like hydrolase domain-containing protein 3 HDHD3;C9orf158 Q9BSH5 ENST00000238379;ENST00000374180 1 0.79769 1.6496 0.92325 1.0341 1.1113 1.2754 TPR_1 cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial membrane;mitochondrial outer membrane;mitochondrial part;organelle membrane;organelle outer membrane;organelle part;outer membrane binding;heat shock protein binding;peptide binding;protein binding;signal sequence binding establishment of localization;establishment of protein localization;intracellular protein transport;intracellular transport;mitochondrial transport;protein import;protein targeting;protein targeting to mitochondrion;protein transport;transport 13 13 13 53.4 53.4 53.4 34.559 6.8157E-227 454570000 232780000 221780000 837 IPI:IPI00009946.4 Mitochondrial import receptor subunit TOM34;Translocase of outer membrane 34 kDa subunit TOMM34;URCC3 Q15785 ENST00000372813 1 0.89421 1.5658 0.8932 1.1666 1.0622 1.0821 PI31_Prot_Reg cell part;cytoplasmic part;cytosol;intracellular part;macromolecular complex;proteasome core complex;protein complex binding;proteasome inhibitor activity;proteasome regulator activity;protein binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Proteasome 9 9 9 36.9 36.9 36.9 29.816 1.1529E-130 652860000 339590000 313260000 838 IPI:IPI00009949.2 Proteasome inhibitor PI31 subunit PSMF1 Q92530 ENST00000333082;ENST00000335877 K06700 1 0.79711 1.4353 0.76027 1.057 0.9964 1.0187 Mov34 cell part;cytoplasmic part;eukaryotic translation initiation factor 3 complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex;signalosome binding;catalytic activity;nucleic acid binding;protein binding;transcription coactivator activity;transcription cofactor activity;transcription factor binding;translation factor activity, nucleic acid binding;translation initiation factor activity nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein deneddylation;protein modification process;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent;translation 14 14 14 46.7 46.7 46.7 37.578 1.2341E-248 282660000 149300000 133350000 839 IPI:IPI00009958.6 COP9 signalosome complex subunit 5;Jun activation domain-binding protein 1 COPS5;CSN5;JAB1 Q92905 ENST00000357849 K09613 1 0.7487 1.638 0.7876 1.0199 1.0217 1.0267 Mitofilin integral to membrane;integral to mitochondrial inner membrane;integral to mitochondrial membrane;integral to organelle membrane;intrinsic to membrane;intrinsic to mitochondrial inner membrane;intrinsic to organelle membrane;organelle part binding;protein binding 38 38 38 54.6 54.6 54.6 83.677 0 1712300000 905440000 806810000 840 IPI:IPI00009960.6;IPI:IPI00554469.1;IPI:IPI00470829.4 Mitochondrial inner membrane protein;Mitofilin;p87/89;Cell proliferation-inducing gene 4 protein IMMT;HMP;PIG4 Q16891-1;Q16891;Q16891-2;Q16891-3 ENST00000254636;ENST00000377310 3 0.8084 2.0065 0.70729 1.0665 1.3147 1.0277 EMP24_GP25L cell part;integral to membrane;intrinsic to membrane;membrane;membrane part;plasma membrane binding;protein binding;receptor binding biological regulation;cell communication;cell-cell signaling;cellular process;establishment of localization;regulation of biological process;regulation of cellular process;signal transduction;transport 3 3 3 17.2 17.2 17.2 25.206 4.4226E-08 32811000 18093000 14719000 842 IPI:IPI00009976.1 Transmembrane emp24 domain-containing protein 1;Interleukin-1 receptor-like 1 ligand;Putative T1/ST2 receptor-binding protein TMED1;IL1RL1L;IL1RL1LG Q13445 ENST00000214869 1 0.73395 1.4181 0.7707 0.96284 0.92041 1.0367 Pkinase cell part;cytoplasm;intracellular part ATP binding;binding;catalytic activity;kinase activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cell communication;intracellular signaling cascade;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;response to oxidative stress;response to stress;signal transduction 18 18 13 41.9 41.9 32.6 58.022 2.4866E-287 600210000 325110000 275100000 844 IPI:IPI00010080.2 Serine/threonine-protein kinase OSR1;Oxidative stress-responsive 1 protein OXSR1;KIAA1101;OSR1 O95747 ENST00000311806 K08835 1 0.78155 1.3893 0.85074 1.0494 0.92801 1.0554 Hist_deacetyl cell part;chromatin remodeling complex;cytoplasm;histone deacetylase complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;catalytic activity;histone deacetylase activity;hydrolase activity;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;protein binding;transcription factor binding;transcription repressor activity cell activation;chromatin organization;defense response;immune system process;leukocyte differentiation;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to stress;transcription 4 4 3 3.6 3.6 2.5 119.04 9.5012E-10 32956000 17347000 15609000 845 IPI:IPI00010088.2 Histone deacetylase 4 HDAC4;KIAA0288 P56524 ENST00000345617 K11406 1 0.79555 1.7769 0.87124 1.1082 1.211 1.1801 Aldo_ket_red cell fraction;cell part;cytoplasmic part;cytosol;intracellular part;soluble fraction binding;catalytic activity;enzyme binding;glutamate-cysteine ligase catalytic subunit binding;oxidoreductase activity;protein binding cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;circulatory system process;organic acid metabolic process;peptide metabolic process;system process;vascular process in circulatory system Glutathione metabolism 8 8 8 35.8 35.8 35.8 30.727 1.8032E-104 116930000 63611000 53323000 846 IPI:IPI00010090.1 Glutamate--cysteine ligase regulatory subunit;Gamma-glutamylcysteine synthetase regulatory subunit;Gamma-ECS regulatory subunit;GCS light chain;Glutamate--cysteine ligase modifier subunit GCLM;GLCLR P48507 ENST00000370238 K11205 1 0.92141 1.3952 0.87616 1.1388 0.98666 1.0854 eIF-6 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;protein binding;ribonucleoprotein binding;ribosome binding;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity anatomical structure formation;biosynthetic process;cellular component assembly;cellular component organization;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;ribonucleoprotein complex assembly;translation 8 8 8 56.7 56.7 56.7 26.599 2.884E-222 1870300000 954610000 915650000 847 IPI:IPI00010105.1 Eukaryotic translation initiation factor 6;B4 integrin interactor;CAB;p27(BBP);B(2)GCN homolog EIF6;EIF3A;ITGB4BP;OK/SW-cl.27 P56537 ENST00000374436;ENST00000374450 K03264 1 1.6895 2.9266 1.5583 2.2173 1.8835 2.0868 Gln-synt_C;Gln-synt_N cell part;cytoplasmic part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle ammonia ligase activity;ATP binding;binding;catalytic activity;glutamate-ammonia ligase activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleoside binding;nucleotide binding;purine nucleoside binding cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;glutamine biosynthetic process;glutamine metabolic process;metabolic process;nitrogen compound metabolic process;organic acid metabolic process Arginine and proline metabolism;Glutamate metabolism;Nitrogen metabolism;Peptidoglycan biosynthesis;Two-component system 9 9 9 24.1 24.1 24.1 42.064 3.4419E-73 133070000 58365000 74707000 849 IPI:IPI00010130.3 Glutamine synthetase;Glutamate--ammonia ligase GLUL;GLNS P15104 ENST00000311223;ENST00000331872;ENST00000339526 K01915 1 0.5818 1.2024 0.57471 0.75655 0.78971 0.76668 DUF1899;DUF1900;WD40 cortical actin cytoskeleton;cortical cytoskeleton;cytoplasmic vesicle membrane;cytoskeleton;endocytic vesicle membrane;filamentous actin;lamellipodium;membrane;organelle membrane;phagocytic cup;phagocytic vesicle membrane;vesicle membrane actin binding;binding;cytoskeletal protein binding;enzyme binding;identical protein binding;kinase binding;phosphoinositide 3-kinase binding;protein binding;protein C-terminus binding;protein dimerization activity;protein homodimerization activity behavior;cell adhesion;cellular process;chemotaxis;defense response;endocytosis;immune response;immune system process;locomotory behavior;membrane invagination;phagocytosis;phagolysosome formation;response to external stimulus;response to stress;transport 28 28 28 53.1 53.1 53.1 51.026 0 11715000000 6526400000 5188100000 850 IPI:IPI00010133.3 Coronin-1A;Coronin-like protein p57;Coronin-like protein A;Tryptophan aspartate-containing coat protein CORO1A;CORO1 P31146 ENST00000219150 1 0.63418 1.2385 0.76655 0.84062 0.80185 1.0155 CBFD_NFYB_HMF cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;DNA binding;DNA polymerase activity;DNA-directed DNA polymerase activity;nucleic acid binding;nucleotidyltransferase activity;protein binding;transferase activity;transferase activity, transferring phosphorus-containing groups biosynthetic process;cellular process;DNA metabolic process;DNA replication;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process DNA replication;Nucleotide excision repair 4 4 4 29.9 29.9 29.9 16.859 3.579E-35 231550000 118830000 112730000 852 IPI:IPI00010141.4 DNA polymerase epsilon subunit 3;DNA polymerase epsilon subunit p17;Chromatin accessibility complex 17;HuCHRAC17;Arsenic-transactivated protein POLE3;CHRAC17 Q9NRF9 ENST00000374169;ENST00000374171 K02326 1 0.86044 1.0865 0.49093 1.0737 0.75785 0.62552 UQ_con cell part;cytoplasmic part;cytosol;intracellular part acid-amino acid ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;ubiquitin-protein ligase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;protein metabolic process;protein modification process;proteolysis;regulation of metabolic process;ubiquitin-dependent protein catabolic process Parkinson's disease;Ubiquitin mediated proteolysis 3 3 3 27.9 27.9 27.9 18.566 2.9137E-69 81662000 47986000 33676000 853 IPI:IPI00010142.1 Ubiquitin-conjugating enzyme E2 G2;Ubiquitin-protein ligase G2;Ubiquitin carrier protein G2 UBE2G2 P60604 ENST00000345496;ENST00000397904 K04555 1 0.70333 1.3834 0.68137 0.9392 0.91228 0.90764 Ribosomal_L14 cell part;cytoplasmic part;cytosol;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome structural constituent of ribosome;structural molecule activity biosynthetic process;intracellular protein transport;macromolecule biosynthetic process;metabolic process;nucleocytoplasmic transport;protein import into nucleus;protein targeting;ribosomal protein import into nucleus;translational elongation;transport Ribosome 7 7 7 40.7 40.7 40.7 14.865 0 4173000000 2258000000 1915000000 854 IPI:IPI00010153.5 60S ribosomal protein L23;Ribosomal protein L17 RPL23 P62829 ENST00000245857;ENST00000394332 K02894 1 0.96607 2.0671 0.98518 1.2717 1.2776 1.2998 GDI cell part;cytoplasm;intracellular part binding;enzyme activator activity;enzyme regulator activity;GDP-dissociation inhibitor activity;GTPase activator activity;GTPase regulator activity;protein binding;Rab GDP-dissociation inhibitor activity;small GTPase regulator activity biological regulation;establishment of localization;establishment of protein localization;protein transport;regulation of catalytic activity;regulation of GTPase activity;regulation of hydrolase activity;regulation of molecular function;transport 25 14 14 59.5 37.4 37.4 50.582 0 379320000 188600000 190720000 855 IPI:IPI00010154.3 Rab GDP dissociation inhibitor alpha;Guanosine diphosphate dissociation inhibitor 1;Oligophrenin-2;Protein XAP-4 GDI1;GDIL;OPHN2;RABGDIA;XAP4 P31150 ENST00000369741 1 0.62114 1.1311 0.60813 0.82015 0.77625 0.81994 S-AdoMet_synt_C;S-AdoMet_synt_M;S-AdoMet_synt_N ATP binding;binding;catalytic activity;magnesium ion binding;methionine adenosyltransferase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;transferase activity cellular metabolic process;cellular process;metabolic process;one-carbon metabolic process Methionine metabolism;Selenoamino acid metabolism 19 19 19 49.9 49.9 49.9 43.66 9.348E-252 2773300000 1471200000 1302000000 856 IPI:IPI00010157.1;IPI:IPI00021772.1 S-adenosylmethionine synthetase isoform type-2;Methionine adenosyltransferase 2;Methionine adenosyltransferase II MAT2A;AMS2;MATA2 P31153 ENST00000306434 K00789 2 0.75889 1.3031 NaN 0.93088 0.95491 NaN CBFD_NFYB_HMF chromatin accessibility complex;chromatin remodeling complex;chromosomal part;DNA polymerase complex;epsilon DNA polymerase complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex binding;catalytic activity;DNA binding;DNA polymerase activity;DNA-directed DNA polymerase activity;nucleic acid binding;nucleotidyltransferase activity;transferase activity;transferase activity, transferring phosphorus-containing groups cellular component organization;cellular process;chromatin modification;chromatin organization;chromatin remodeling;chromosome organization;organelle organization 2 2 2 19.8 19.8 19.8 14.71 9.1001E-90 59039000 32602000 26438000 857 IPI:IPI00010158.3 Chromatin accessibility complex protein 1;CHRAC-15;HuCHRAC15;DNA polymerase epsilon subunit p15 CHRAC1;CHRAC15 Q9NRG0 ENST00000220913 K11656 1 0.65807 1.65 0.74729 0.94571 0.98121 1.0727 ACBP acyl-CoA binding;benzodiazepine receptor binding;binding;carboxylic acid binding;coenzyme binding;cofactor binding;fatty acid binding;lipid binding;monocarboxylic acid binding;protein binding;receptor binding establishment of localization;transport PPAR signaling pathway 10 10 10 94.3 94.3 94.3 10.044 1.0703E-93 1630500000 881900000 748620000 858 IPI:IPI00010182.4;IPI:IPI00218836.1 Acyl-CoA-binding protein;Diazepam-binding inhibitor;Endozepine DBI P07108-1;P07108;P07108-2 ENST00000311521;ENST00000355857;ENST00000401684;ENST00000409094 K08762 2 0.90896 1.4987 0.94986 1.1697 1.0348 1.1895 adh_short cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;microbody;organelle;peroxisome 2,4-dienoyl-CoA reductase (NADPH) activity;binding;catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on the CH-CH group of donors;oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor metabolic process;oxidation reduction 7 7 7 25.7 25.7 25.7 30.777 1.0472E-100 97246000 51111000 46135000 860 IPI:IPI00010190.3;IPI:IPI00640806.2;IPI:IPI00444050.1 Peroxisomal 2,4-dienoyl-CoA reductase;2,4-dienoyl-CoA reductase 2 DECR2;PDCR Q9NUI1-1;Q9NUI1;Q9NUI1-3;Q9NUI1-2 ENST00000219481;ENST00000397710 K00219 3 0.57862 1.0686 0.58077 0.75166 0.68059 0.7319 Ank;DUF1605;HA2;Helicase_C;R3H;YTH catalytic activity;helicase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleoside-triphosphatase activity;pyrophosphatase activity 12 12 12 10 10 10 160.25 7.2442E-187 247460000 128900000 118560000 862 IPI:IPI00010200.3 Probable ATP-dependent RNA helicase YTHDC2 YTHDC2 Q9H6S0 ENST00000161863 1 0.81268 1.4271 0.88201 1.0302 0.94597 1.1521 RRM_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 7 6 6 38.4 38.4 38.4 19.329 9.2557E-80 6253100000 3145000000 3108100000 863 IPI:IPI00010204.1 Splicing factor, arginine/serine-rich 3;Pre-mRNA-splicing factor SRP20 SFRS3;SRP20 P84103 ENST00000373715 1 0.94018 1.578 0.95629 1.2408 0.94072 1.2247 Ufm1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 4 4 4 68.2 68.2 68.2 9.1175 9.5422E-13 289130000 143330000 145800000 864 IPI:IPI00010207.1 Ubiquitin-fold modifier 1 UFM1;C13orf20;BM-002 P61960 ENST00000239878;ENST00000379649 K12162 1 NaN 0.69466 NaN NaN 0.41955 NaN PAP_assoc;RRM_1 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;catalytic activity;cation binding;ion binding;nucleic acid binding;nucleotide binding;nucleotidyltransferase activity;RNA binding;transferase activity;transferase activity, transferring phosphorus-containing groups;zinc ion binding 4 4 4 7.8 7.8 7.8 93.846 1.9812E-121 6312800 3155700 3157000 865 IPI:IPI00010212.6 U6 snRNA-specific terminal uridylyltransferase 1;RNA-binding motif protein 21 TUT1;RBM21 Q9H6E5 ENST00000278279 1 0.56872 1.6575 0.70148 0.76609 0.94515 0.94555 Spindle_Spc25 condensed chromosome kinetochore;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;kinetochore;macromolecular complex;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle binding;protein binding cell cycle phase;cell cycle process;cell division;cellular component organization;cellular process;mitosis;nuclear division;organelle fission;organelle organization 5 5 5 28.1 28.1 28.1 26.152 6.222E-16 21818000 8115900 13702000 867 IPI:IPI00010219.1 Kinetochore protein Spc25 SPC25;SPBC25;AD024 Q9HBM1 ENST00000282074 K11550 1 0.66858 1.3841 0.87984 0.93459 0.86188 1.1022 Peroxin-3 integral to membrane;integral to organelle membrane;integral to peroxisomal membrane;intracellular part;intrinsic to membrane;intrinsic to organelle membrane;intrinsic to peroxisomal membrane;membrane part;microbody part;organelle part;peroxisomal part binding;protein binding establishment of protein localization;intracellular protein transport;peroxisomal transport;protein import;protein import into peroxisome membrane;protein targeting;protein targeting to membrane;protein targeting to peroxisome;protein transport;transport 4 4 4 13.9 13.9 13.9 42.139 2.5408E-121 86119000 42226000 43893000 868 IPI:IPI00010232.1 Peroxisomal biogenesis factor 3;Peroxin-3;Peroxisomal assembly protein PEX3 PEX3 P56589 ENST00000367591 1 0.66074 1.6344 0.73024 0.99312 1.0346 1.0581 Ribosomal_S11 cytoplasmic part;intracellular part;macromolecular complex;mitochondrial part;mitochondrial small ribosomal subunit;organellar small ribosomal subunit;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit structural constituent of ribosome;structural molecule activity biosynthetic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;response to DNA damage stimulus;response to stress;translation 4 4 4 22.2 22.2 22.2 20.616 4.3426E-22 41943000 22914000 19029000 870 IPI:IPI00010244.4;IPI:IPI00219350.1;IPI:IPI00219351.3 28S ribosomal protein S11, mitochondrial;MRP-S11;Cervical cancer proto-oncogene 2 protein MRPS11;RPMS11;HCC2 P82912-1;P82912;P82912-2;P82912-3 ENST00000325844;ENST00000353598 3 NaN 1.5199 NaN NaN 1.0139 NaN Abhydrolase_1 clathrin-coated vesicle;coated vesicle;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;cytosol;endosome membrane;Golgi-associated vesicle;membrane;organelle membrane;trans-Golgi network transport vesicle;transport vesicle;vesicle binding;CD4 receptor binding;protein binding;receptor binding activation of immune response;immune response-activating cell surface receptor signaling pathway;immune response-activating signal transduction;immune system process;positive regulation of immune system process;regulation of immune system process 3 3 3 12 12 12 34.96 1.4477E-07 1112400 663050 449310 871 IPI:IPI00010248.3 Maspardin;Spastic paraplegia 21 autosomal recessive Mast syndrome protein;Acid cluster protein 33 SPG21;ACP33;BM-019;GL010 Q9NZD8 ENST00000204566 1 0.76364 1.2834 0.73586 1.0096 0.90113 1.0273 Bromodomain;PHD;zf-B_box cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;cation binding;co-SMAD binding;DNA binding;ion binding;ligase activity;metal ion binding;nucleic acid binding;protein binding;R-SMAD binding;SMAD binding;transition metal ion binding;zinc ion binding catabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein modification process;proteolysis;regulation of transcription, DNA-dependent;transcription 14 14 14 14.9 14.9 14.9 122.52 2.3418E-170 132180000 68675000 63507000 872 IPI:IPI00010252.3;IPI:IPI00221114.1 E3 ubiquitin-protein ligase TRIM33;Tripartite motif-containing protein 33;Transcription intermediary factor 1-gamma;Ectodermin homolog;RET-fused gene 7 protein TRIM33;KIAA1113;RFG7;TIF1G Q9UPN9-1;Q9UPN9;Q9UPN9-2 ENST00000358465;ENST00000369543 K08883 2 0.83817 1.7274 0.85985 1.124 1.1732 1.0954 Ras cell part;cytoplasm;intracellular part binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity cell communication;cellular process;intracellular signaling cascade;regulation of cellular metabolic process;regulation of hydrogen peroxide metabolic process;regulation of metabolic process;signal transduction;small GTPase mediated signal transduction Adherens junction;Axon guidance;B cell receptor signaling pathway;Chemokine signaling pathway;Colorectal cancer;Fc epsilon RI signaling pathway;Focal adhesion;Leukocyte transendothelial migration;MAPK signaling pathway;Natural killer cell mediated cytotoxicity;Pancreatic cancer;Pathways in cancer;Regulation of actin cytoskeleton;VEGF signaling pathway;Wnt signaling pathway 12 6 6 55.7 24 24 21.429 1.7682E-130 1735600000 837220000 898410000 874 IPI:IPI00010270.1;IPI:IPI00027952.1;IPI:IPI00012511.6;IPI:IPI00249526.1 Ras-related C3 botulinum toxin substrate 2;p21-Rac2;Small G protein;GX RAC2 P15153 ENST00000249071 K07860 4 0.8471 1.7706 0.86683 1.123 1.1325 1.1417 Ras cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;melanosome;membrane;membrane-bounded organelle;membrane-bounded vesicle;organelle;plasma membrane;vesicle binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity actin filament organization;cell adhesion;cell communication;cell motion;cytoskeleton organization;defense response;inflammatory response;organelle organization;protein complex assembly;response to stress;signal transduction Adherens junction;Amyotrophic lateral sclerosis (ALS);Axon guidance;B cell receptor signaling pathway;Chemokine signaling pathway;Colorectal cancer;Epithelial cell signaling in Helicobacter pylori infection;Fc epsilon RI signaling pathway;Focal adhesion;Leukocyte transendothelial migration;MAPK signaling pathway;Natural killer cell mediated cytotoxicity;Pancreatic cancer;Pathways in cancer;Regulation of actin cytoskeleton;Renal cell carcinoma;Toll-like receptor signaling pathway;VEGF signaling pathway;Wnt signaling pathway 12 12 3 50.7 50.7 13.7 23.467 1.1031E-127 5002800000 2651400000 2351400000 875 IPI:IPI00219675.1;IPI:IPI00010271.3 Ras-related C3 botulinum toxin substrate 1;p21-Rac1;Ras-like protein TC25;Cell migration-inducing gene 5 protein RAC1;MIG5 P63000-2;P63000;P63000-1 ENST00000348035;ENST00000356142 K04392 2 0.68231 1.4865 0.7013 0.89427 0.987 0.9124 PDCD9 intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;mitochondrion;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome structural constituent of ribosome;structural molecule activity apoptosis;biosynthetic process;cell death;cellular macromolecule biosynthetic process;cellular process;death;macromolecule biosynthetic process;metabolic process;programmed cell death;protein metabolic process;translation 9 9 9 23 23 23 50.364 7.3666E-24 180430000 94944000 85489000 876 IPI:IPI00010278.6 28S ribosomal protein S30, mitochondrial;MRP-S30;Programmed cell death protein 9 MRPS30;PDCD9;BM-047 Q9NP92 ENST00000230914 1 0.71405 1.4309 0.80852 0.90292 0.90181 1.1619 Chromo;Chromo_shadow chromatin;chromosome, centromeric region;heterochromatin;intracellular non-membrane-bounded organelle;intracellular organelle;non-membrane-bounded organelle;nuclear chromatin;nuclear heterochromatin;nucleoplasm;organelle;organelle part;spindle binding;chromatin binding;protein binding cellular component organization;cellular process;chromatin assembly or disassembly;chromatin organization;chromosome organization;organelle organization 6 5 5 28.1 19.5 19.5 21.418 2.3037E-181 78560000 40222000 38337000 877 IPI:IPI00010320.1 Chromobox protein homolog 1;Heterochromatin protein 1 homolog beta;Modifier 1 protein;M31;Heterochromatin protein p25;HP1Hsbeta;p25beta CBX1;CBX P83916 ENST00000225603;ENST00000393408 K11585 1 NaN 1.5167 NaN NaN 1.002 NaN SIR2 binding;catalytic activity;hydrolase activity;NAD+ ADP-ribosyltransferase activity;nucleotide binding;transferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring pentosyl groups;zinc ion binding chromatin silencing;metabolic process;protein amino acid ADP-ribosylation;protein amino acid deacetylation;protein modification process;regulation of biosynthetic process;regulation of transcription, DNA-dependent 5 5 5 21.9 21.9 21.9 33.881 4.9821E-49 7110800 4296600 2814200 878 IPI:IPI00016807.1;IPI:IPI00010331.1 NAD-dependent deacetylase sirtuin-5;SIR2-like protein 5 SIRT5;SIR2L5 Q9NXA8-1;Q9NXA8;Q9NXA8-2 ENST00000379250;ENST00000379262;ENST00000397350 K11415 2 0.59905 1.2484 0.60714 0.80251 0.82548 0.80157 Peptidase_M3 cell part;cytoplasmic part;intracellular organelle part;intracellular part;membrane-enclosed lumen;mitochondrial intermembrane space;mitochondrial part;organelle envelope lumen;organelle part binding;catalytic activity;cation binding;endopeptidase activity;hydrolase activity;ion binding;metal ion binding;metalloendopeptidase activity;metallopeptidase activity;peptidase activity;transition metal ion binding;zinc ion binding biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis Renin-angiotensin system 15 15 15 25.7 25.7 25.7 80.651 9.4705E-125 251090000 142780000 108310000 879 IPI:IPI00010346.1 Neurolysin, mitochondrial;Neurotensin endopeptidase;Mitochondrial oligopeptidase M;Microsomal endopeptidase;Angiotensin-binding protein NLN;AGTBP;KIAA1226 Q9BYT8 ENST00000340159 K01393 1 1.1337 1.6726 0.96119 1.4822 1.1935 1.1308 DNase_II cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;lysosome;lytic vacuole;membrane-bounded organelle;organelle;vacuole binding;catalytic activity;deoxyribonuclease activity;deoxyribonuclease II activity;DNA binding;endodeoxyribonuclease activity;endonuclease activity;hydrolase activity;nuclease activity;nucleic acid binding;protein binding apoptosis;cell death;cellular process;death;programmed cell death 3 3 3 10.3 10.3 10.3 39.58 1.3649E-17 49828000 24963000 24865000 880 IPI:IPI00010348.1 Deoxyribonuclease-2-alpha;Deoxyribonuclease II alpha;Acid DNase;Lysosomal DNase II;R31240_2 DNASE2;DNASE2A;DNL2 O00115 ENST00000222219 K01158 1 0.7713 1.3814 0.72792 1.0268 0.92901 0.96759 FAD_binding_4;FAD-oxidase_C cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;microbody;microbody membrane;microbody part;organelle;organelle membrane;organelle part;peroxisomal membrane;peroxisomal part alkylglycerone-phosphate synthase activity;binding;catalytic activity;nucleoside binding;nucleotide binding;oxidoreductase activity;purine nucleoside binding;transferase activity;transferase activity, transferring alkyl or aryl (other than methyl) groups biosynthetic process;lipid biosynthetic process;lipid metabolic process;metabolic process;primary metabolic process Ether lipid metabolism 18 18 18 37.1 37.1 37.1 72.911 1.2035E-186 424800000 231210000 193590000 881 IPI:IPI00010349.1 Alkyldihydroxyacetonephosphate synthase, peroxisomal;Alkylglycerone-phosphate synthase;Aging-associated gene 5 protein AGPS;AAG5 O00116 ENST00000264167 K00803 1 0.63593 0.71435 NaN 0.95584 0.45173 NaN UBX fertilization;reproductive process;single fertilization 2 2 2 8.5 8.5 8.5 30.541 0.00016786 1698800 912620 786200 882 IPI:IPI00010353.1;IPI:IPI00414693.2 UBX domain-containing protein 8;UBX domain-containing protein 6;Reproduction 8 protein UBXN8;D8S2298E;REP8;UBXD6 O00124-1;O00124;O00124-3 ENST00000265616;ENST00000341403;ENST00000380154 2 0.74772 1.409 0.75121 0.9828 0.95699 0.96282 Kinesin centrosome;cytoplasmic part;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;microtubule;microtubule organizing center;non-membrane-bounded organelle;organelle;organelle part ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;microtubule motor activity;motor activity;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity anatomical structure development;cell differentiation;cellular developmental process;cellular process;developmental process;microtubule-based movement;microtubule-based process;nervous system development;system development 15 15 14 19.1 19.1 17.1 84.088 1.2503E-225 415620000 214930000 200680000 883 IPI:IPI00848334.1;IPI:IPI00867746.1;IPI:IPI00010368.6;IPI:IPI00867529.1 Kinesin-like protein KIF2A;HK2 KIF2A;KIF2;KNS2 O00139-4;O00139;O00139-3;O00139-1;O00139-2 ENST00000230731;ENST00000401507;ENST00000407818 K10393 4 0.59538 1.5879 0.38164 0.76295 1.1153 0.48259 Cenp-B_dimeris;CENP-B_N;CenpB-DNA-bind;DDE cell part;chromosomal part;chromosome, centromeric region;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;nucleus;organelle;organelle part binding;chromatin binding;DNA binding;nucleic acid binding;satellite DNA binding;sequence-specific DNA binding regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of metabolic process;regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3 3 3 7.3 7.3 7.3 65.171 2.3481E-60 6671000 3372500 3298500 884 IPI:IPI00010388.1 Major centromere autoantigen B;CENP-B CENPB P07199 ENST00000379751 K11496 1 0.67395 1.4477 0.71623 0.84978 0.94948 1.0058 SF3b10 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 7 7 7 68.6 68.6 68.6 10.135 3.0396E-68 510100000 268110000 241990000 885 IPI:IPI00010404.1 Splicing factor 3B subunit 5;Pre-mRNA-splicing factor SF3b 10 kDa subunit SF3B5;SF3B10 Q9BWJ5 ENST00000367569 1 0.80369 1.5886 0.80356 1.0636 1.0281 1.0453 LIM;PDZ cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding response to chemical stimulus;response to oxidative stress;response to stimulus;response to stress 16 16 16 49.8 49.8 49.8 36.071 3.1808E-281 978470000 512970000 465500000 886 IPI:IPI00010414.4 PDZ and LIM domain protein 1;Elfin;LIM domain protein CLP-36;C-terminal LIM domain protein 1 PDLIM1;CLIM1;CLP36 O00151 ENST00000329399 1 0.78144 1.5057 0.94799 0.98689 1.0304 1.2041 DUF786 cell part;integral to membrane;intrinsic to membrane;membrane part 2 2 2 20 20 20 12.017 1.4483E-07 39754000 19948000 19806000 888 IPI:IPI00010427.1 Transmembrane protein 93 TMEM93 Q9BV81 ENST00000248378;ENST00000397133 1 0.97296 2.3803 1.2032 1.2906 1.5202 1.5299 SNAP-25;SNARE cell fraction;cell junction;cytoplasm;insoluble fraction;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane fraction;membrane part;membrane-bounded organelle;nucleus;organelle;plasma membrane part;synaptosome binding;protein binding cellular component organization;cellular process;establishment of protein localization;membrane fusion;membrane organization;post-Golgi vesicle-mediated transport;protein transport;transport;vesicle targeting;vesicle-mediated transport SNARE interactions in vesicular transport 4 4 4 24.6 24.6 24.6 23.354 2.3702E-82 100890000 52605000 48284000 889 IPI:IPI00010438.2;IPI:IPI00216231.2 Synaptosomal-associated protein 23;Vesicle-membrane fusion protein SNAP-23 SNAP23 O00161-1;O00161;O00161-2 ENST00000249647;ENST00000349777 K08508 2 0.81756 1.4335 0.88769 1.0655 0.93948 1.1169 actin cytoskeleton;cell fraction;cytoskeleton;endoplasmic reticulum;intracellular organelle;membrane;membrane-bounded organelle;mitochondrion;non-membrane-bounded organelle;nuclear membrane;organelle;organelle membrane;soluble fraction binding;cytokine binding;growth factor binding;interleukin-1 binding;protein binding;protein N-terminus binding 9 9 9 33.8 33.8 33.8 32.418 6.5898E-37 161150000 83117000 78037000 890 IPI:IPI00641973.4;IPI:IPI00010440.6;IPI:IPI00604587.1;IPI:IPI00954512.1;IPI:IPI00878396.1;IPI:IPI00954523.1 HCLS1-associated protein X-1;HS1-associating protein X-1;HS1-binding protein 1 HAX1;HS1BP1 O00165-2;O00165;O00165-1;O00165-5;O00165-3 ENST00000328703 6 0.55591 1.2319 NaN 0.78 0.79414 NaN DEAD;Helicase_C;zf-HIT cell part;intracellular ATP binding;ATP-dependent helicase activity;binding;catalytic activity;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity;RNA binding;zinc ion binding 4 4 4 6.3 6.3 6.3 68.809 4.7499E-37 13683000 7957700 5725500 891 IPI:IPI00217157.5;IPI:IPI00010449.2 Probable ATP-dependent RNA helicase DDX59;DEAD box protein 59;Zinc finger HIT domain-containing protein 5 DDX59;ZNHIT5 Q5T1V6-1;Q5T1V6;Q5T1V6-2 ENST00000331314;ENST00000367349 2 1.0357 1.4786 NaN 1.3555 0.94385 NaN GTP_EFTU;GTP_EFTU_D2;GTP_EFTU_D3 binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleotide binding;pyrophosphatase activity biological regulation;cell communication;cellular process;immune response;immune system process;regulation of biological process;regulation of cellular process;response to stimulus;signal transduction 4 4 4 8.2 8.2 8.2 72.453 1.1834E-141 4986200 2728600 2257600 892 IPI:IPI00010463.5 GTP-binding protein 1 GTPBP1 O00178 ENST00000216044 1 0.55672 1.3005 0.52356 0.76853 0.81693 0.71397 C1_1;C2;Pkinase;Pkinase_C cell part;cytoplasmic part;cytosol;intracellular part;membrane;plasma membrane ATP binding;binding;calcium ion binding;catalytic activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein kinase C activity;protein serine/threonine kinase activity;purine nucleoside binding;zinc ion binding cell communication;cellular process;intracellular signaling cascade;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;protein transport;signal transduction;transport Calcium signaling pathway;ErbB signaling pathway;Focal adhesion;Gap junction;Glioma;Leukocyte transendothelial migration;Long-term depression;Long-term potentiation;MAPK signaling pathway;MAPK signaling pathway - yeast;Melanogenesis;Natural killer cell mediated cytotoxicity;Non-small cell lung cancer;Pathways in cancer;Phosphatidylinositol signaling system;Tight junction;Vascular smooth muscle contraction;VEGF signaling pathway;Vibrio cholerae infection;Wnt signaling pathway 10 4 4 14.1 3.9 3.9 77.011 9.6547E-114 41254000 23242000 18012000 893 IPI:IPI00219628.3;IPI:IPI00010466.3 Protein kinase C beta type PRKCB;PKCB;PRKCB1 P05771-2;P05771;P05771-1 ENST00000303531;ENST00000321728 K02677 2 0.95716 1.8467 0.98278 1.2463 1.2069 1.2562 CH;efhand cell part;cytoplasmic part;cytosol;intracellular part binding;calcium ion binding;cation binding;ion binding;metal ion binding 54 54 47 77.8 77.8 74.2 70.289 0 56386000000 26489000000 29897000000 894 IPI:IPI00010471.5 Plastin-2;L-plastin;Lymphocyte cytosolic protein 1;LC64P LCP1;PLS2 P13796 ENST00000323076;ENST00000398576 1 0.5429 0.97489 0.52435 0.66936 0.69203 0.64293 Gal-bind_lectin cell part;cytoplasm;extracellular region;intracellular part binding;carbohydrate binding;galactose binding;molecular transducer activity;monosaccharide binding;signal transducer activity;sugar binding positive regulation of cell communication;positive regulation of protein kinase cascade;positive regulation of signal transduction;regulation of cell communication;regulation of protein kinase cascade;regulation of signal transduction 5 5 5 17.2 17.2 17.2 39.518 1.8626E-75 215850000 117560000 98290000 895 IPI:IPI00010477.1;IPI:IPI00293267.1;IPI:IPI00472523.3;IPI:IPI00456941.6;IPI:IPI00903067.1 Galectin-9;HOM-HD-21;Ecalectin LGALS9 O00182-1;O00182;O00182-2 ENST00000302228;ENST00000395473 5 1.0048 1.9338 NaN 1.2738 1.3605 NaN PA26 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle cell cycle arrest;cell cycle process;cellular process p53 signaling pathway 4 4 4 9.6 9.6 9.6 54.493 1.5165E-11 8863600 4453200 4410400 896 IPI:IPI00010539.1 Sestrin-2;Hi95 SESN2;SEST2 P58004 ENST00000253063 K10141 1 1.1178 1.5006 0.89859 1.3828 1.0016 1.1173 cell junction;cell part;cell-cell junction;cytoplasmic part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane part;membrane-bounded organelle;organelle;plasma membrane part;tight junction binding;protein binding Tight junction 2 2 2 4.3 4.3 4.3 61.82 1.1404E-06 6436900 3140900 3296000 897 IPI:IPI00010544.3;IPI:IPI00643168.3;IPI:IPI00654613.1 Tight junction-associated protein 1;Tight junction protein 4;Protein incorporated later into tight junctions TJAP1;PILT;TJP4 Q5JTD0-1;Q5JTD0;Q5JTD0-2;Q5JTD0-4 ENST00000372445;ENST00000372446;ENST00000372449 K06105 3 1.0348 2.544 1.0076 1.6147 1.5205 1.3476 cell part;cytoplasmic part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle binding;DNA binding;nucleic acid binding;protein binding;RNA polymerase II transcription factor activity;transcription cofactor activity;transcription factor binding;transcription regulator activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent 6 6 6 7.7 7.7 7.7 123.15 1.797E-21 17742000 7626300 10116000 898 IPI:IPI00010586.3;IPI:IPI00930399.1 TATA element modulatory factor;Androgen receptor coactivator 160 kDa protein TMF1 P82094-2;P82094;P82094-1 ENST00000398559 2 0.4359 0.76206 0.42149 0.56353 0.49988 0.5566 Helicase_C;SNF2_N cell part;centromeric heterochromatin;chromatin;chromosomal part;heterochromatin;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;nucleus;organelle;organelle part ATP binding;binding;catalytic activity;DNA binding;helicase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity cell activation;chromatin assembly or disassembly;chromatin organization;chromatin remodeling;chromatin silencing;DNA metabolic process;immune system process;nuclear division;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 20 20 19 24.3 24.3 23.6 97.073 9.6007E-82 370080000 214660000 155420000 899 IPI:IPI00010590.2;IPI:IPI00807455.1;IPI:IPI00807597.1;IPI:IPI00807574.1;IPI:IPI00807726.1;IPI:IPI00807553.1;IPI:IPI00807667.1;IPI:IPI00807698.1;IPI:IPI00807418.1 Lymphoid-specific helicase;SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6;Proliferation-associated SNF2-like protein HELLS;PASG;SMARCA6;Nbla10143 Q9NRZ9-1;Q9NRZ9;Q9NRZ9-2;Q9NRZ9-4;Q9NRZ9-3;Q9NRZ9-5;Q9NRZ9-6 ENST00000348459;ENST00000371332;ENST00000394036;ENST00000394044;ENST00000394045 9 0.5946 1.2339 NaN 0.78614 0.81279 NaN Exonuc_X-T cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;catalytic activity;DNA binding;exonuclease activity;hydrolase activity;hydrolase activity, acting on ester bonds;nuclease activity;nucleic acid binding;transcription factor activity;transcription regulator activity regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent 6 6 6 18.2 18.2 18.2 46.671 2.566E-12 12633000 6697000 5935900 900 IPI:IPI00010653.6;IPI:IPI00513877.2 RNA exonuclease 4;Exonuclease XPMC2;Prevents mitotic catastrophe 2 protein homolog REXO4;PMC2;XPMC2H Q9GZR2-1;Q9GZR2 ENST00000371935;ENST00000371942 K01175 2 0.44765 1.3633 0.61333 0.73787 0.90848 0.82268 BAT2_N cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding 12 12 12 9.1 9.1 9.1 228.86 3.2401E-112 51692000 27091000 24601000 901 IPI:IPI00010700.2;IPI:IPI00642817.2;IPI:IPI00084746.4;IPI:IPI00885161.1 Large proline-rich protein BAT2;HLA-B-associated transcript 2 BAT2;G2 P48634-1;P48634;P48634-3;P48634-2;P48634-4 ENST00000376007;ENST00000376010;ENST00000383267;ENST00000383272;ENST00000383455;ENST00000383464 4 0.8428 1.4289 0.88778 1.0517 0.96635 1.0987 GSH_synth_ATP;GSH_synthase acid-amino acid ligase activity;ATP binding;binding;catalytic activity;glutathione synthase activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleoside binding;nucleotide binding;purine nucleoside binding;purine nucleotide binding cellular amino acid and derivative metabolic process;cellular amino acid derivative metabolic process;cellular amino acid metabolic process;coenzyme metabolic process;glutathione metabolic process;organic acid metabolic process;peptide metabolic process Glutathione metabolism 16 16 16 42.6 42.6 42.6 52.384 7.8708E-247 521500000 267260000 254250000 902 IPI:IPI00010706.1 Glutathione synthetase;Glutathione synthase;GSH synthetase GSS P48637 ENST00000216951 K01920 1 NaN 1.2578 NaN NaN 0.77914 NaN GHMP_kinases_C;GHMP_kinases_N cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;microbody;organelle;peroxisome ATP binding;binding;catalytic activity;kinase activity;mevalonate kinase activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups alcohol metabolic process;cholesterol biosynthetic process;isoprenoid metabolic process;lipid metabolic process;metabolic process;phosphate metabolic process;phosphorus metabolic process;steroid biosynthetic process;steroid metabolic process Biosynthesis of steroids 2 2 2 8.1 8.1 8.1 42.45 1.164E-10 2329000 1202900 1126200 903 IPI:IPI00010717.1 Mevalonate kinase MVK Q03426 ENST00000228510;ENST00000392727 K00869 1 0.87266 1.7216 0.89902 1.1765 1.121 1.1935 Cpn60_TCP1 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 41 41 41 71 71 71 59.67 0 11235000000 5780900000 5454400000 904 IPI:IPI00010720.1 T-complex protein 1 subunit epsilon;CCT-epsilon CCT5;CCTE;KIAA0098 P48643 ENST00000280326 K09497 1 0.79087 1.4788 0.78631 1.0362 0.99072 1.0396 NOPS;RRM_1 cell part;intracellular organelle part;intracellular part;nuclear matrix;nuclear part;organelle part binding;DNA binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding DNA metabolic process;DNA recombination;DNA repair;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;RNA processing;transcription 26 25 25 35.4 34.2 34.2 76.149 0 10039000000 5168200000 4870700000 905 IPI:IPI00010740.1;IPI:IPI00216613.1 Splicing factor, proline- and glutamine-rich;Polypyrimidine tract-binding protein-associated-splicing factor;DNA-binding p52/p100 complex, 100 kDa subunit;100 kDa DNA-pairing protein SFPQ;PSF P23246-1;P23246;P23246-2 ENST00000357214 2 0.82251 1.3846 0.77843 1.0984 0.99364 1.0554 PSS cell part;integral to membrane;intrinsic to membrane;membrane part catalytic activity;transferase activity glycerophospholipid metabolic process;lipid biosynthetic process;lipid metabolic process;metabolic process;phosphatidylserine biosynthetic process;phosphatidylserine metabolic process;phospholipid biosynthetic process;phospholipid metabolic process Glycerophospholipid metabolism 4 4 4 12.5 12.5 12.5 55.527 1.2193E-65 48719000 25040000 23680000 906 IPI:IPI00010746.1 Phosphatidylserine synthase 1;Serine-exchange enzyme I PTDSS1;KIAA0024;PSSA P48651 ENST00000337004 K08729 1 NaN 1.7586 0.71194 NaN 1.0902 0.95825 zf-C3HC4;zf-RanBP cell part;intracellular binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 3 3 3 8 8 8 57.571 2.041E-08 1933100 1023800 909250 907 IPI:IPI00783058.1;IPI:IPI00010748.2;IPI:IPI00220104.1 RanBP-type and C3HC4-type zinc finger-containing protein 1;Ubiquitin-conjugating enzyme 7-interacting protein 3;Hepatitis B virus X-associated protein 4;HBV-associated factor 4;RING finger protein 54 RBCK1;C20orf18;RNF54;UBCE7IP3;XAP3;XAP4 Q9BYM8-1;Q9BYM8;Q9BYM8-3 ENST00000353660;ENST00000356286;ENST00000400244 3 0.93913 2.3033 0.95413 1.2764 1.3302 1.3741 Tropomyosin cell part;contractile fiber part;cytoplasmic part;cytoskeletal part;intracellular organelle part;intracellular part;muscle thin filament tropomyosin;organelle part actin binding;binding;calcium ion binding;cation binding;cytoskeletal protein binding;ion binding;metal ion binding;protein binding;structural constituent of muscle;structural molecule activity cell motion;cellular process Cardiac muscle contraction 29 19 16 76.6 50 50 28.521 0 4589400000 2313700000 2275800000 908 IPI:IPI00010779.4;IPI:IPI00216975.1 Tropomyosin alpha-4 chain;Tropomyosin-4;TM30p1 TPM4 P67936-1;P67936;P67936-2 ENST00000300933;ENST00000344824;ENST00000403340 K10375 2 0.86502 1.7844 0.91517 1.1853 1.1679 1.2036 Thioredoxin cell surface;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;endoplasmic reticulum;endoplasmic reticulum lumen;ER-Golgi intermediate compartment;extracellular region;membrane;membrane-enclosed lumen;plasma membrane;vesicle binding;catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;procollagen-proline 4-dioxygenase activity;protein binding;protein disulfide isomerase activity amine metabolic process;cellular amino acid and derivative metabolic process;cellular amino acid derivative metabolic process;metabolic process;nitrogen compound metabolic process;organic acid metabolic process;protein modification process 34 34 34 61.2 61.2 61.2 57.116 0 5679200000 2945500000 2733700000 909 IPI:IPI00010796.1 Protein disulfide-isomerase;Prolyl 4-hydroxylase subunit beta;Cellular thyroid hormone-binding protein;p55 P4HB;ERBA2L;PDI;PDIA1;PO4DB P07237 ENST00000331483 K09580 1 0.84296 1.7326 0.85743 1.1174 1.1107 1.1371 ETF;ETF_alpha cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part adenyl nucleotide binding;binding;coenzyme binding;cofactor binding;electron carrier activity;FAD binding;nucleoside binding;nucleotide binding;purine nucleoside binding;purine nucleotide binding cellular metabolic process;cellular process;electron transport chain;establishment of localization;generation of precursor metabolites and energy;metabolic process;oxidation reduction;transport 12 12 12 46.2 46.2 46.2 35.079 0 839920000 435580000 404340000 910 IPI:IPI00010810.1 Electron transfer flavoprotein subunit alpha, mitochondrial ETFA P13804 ENST00000267950 K03522 1 0.86993 1.5774 NaN 1.1861 0.95108 NaN zf-C2H2 DNA-directed RNA polymerase complex;DNA-directed RNA polymerase II, core complex;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;organelle;RNA polymerase complex binding;cation binding;ion binding;metal ion binding;RNA polymerase II transcription factor activity;specific RNA polymerase II transcription factor activity;transcription regulator activity;transition metal ion binding;zinc ion binding negative regulation of transcription from RNA polymerase II promoter;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 4 4 4 5.3 5.3 5.3 88.975 0.00013278 16148000 8117900 8030300 911 IPI:IPI00010833.1 Zinc finger protein 148;Zinc finger DNA-binding protein 89;Transcription factor ZBP-89 ZNF148;ZBP89 Q9UQR1 ENST00000360647 1 1.0451 2.0815 1.1205 1.3323 1.3203 1.3741 Gal-bind_lectin cell part;cytoplasm;extracellular region part;extracellular space;intracellular part binding;carbohydrate binding;sugar binding 4 4 4 12.5 12.5 12.5 40.397 3.0406E-51 191490000 97321000 94169000 912 IPI:IPI00165587.3;IPI:IPI00215644.2;IPI:IPI00010844.2 Galectin-8;Prostate carcinoma tumor antigen 1;Po66 carbohydrate-binding protein LGALS8 O00214-2;O00214;O00214-3;O00214-1 ENST00000323938;ENST00000341872;ENST00000352231;ENST00000356238;ENST00000366584;ENST00000406509 K06832 3 0.8426 1.4589 0.65812 1.0539 0.99291 0.81893 Fer4 cytoplasmic part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;mitochondrial membrane part;mitochondrial part;mitochondrial respiratory chain complex I;NADH dehydrogenase complex;organelle part;protein complex binding;catalytic activity;electron carrier activity;iron ion binding;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH cellular process;generation of precursor metabolites and energy;metabolic process;mitochondrial electron transport, NADH to ubiquinone;NADH dehydrogenase complex assembly;protein complex assembly;response to oxidative stress;response to stress;transport Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 5 5 5 28.1 28.1 28.1 23.705 1.4695E-133 86057000 46816000 39240000 913 IPI:IPI00010845.3 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial;NADH-ubiquinone oxidoreductase 23 kDa subunit;Complex I-23kD;TYKY subunit NDUFS8 O00217 ENST00000313468 K03941 1 0.88242 1.6053 0.85918 1.1438 1.1568 1.0824 cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;proteasome regulatory particle;protein complex bHLH transcription factor binding;binding;protein binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding;transcription regulator activity catabolic process;macromolecule catabolic process;metabolic process;negative regulation of peptide secretion;positive regulation of peptide secretion;proteolysis;regulation of peptide secretion;ubiquitin-dependent protein catabolic process 5 5 5 28.7 28.7 28.7 24.653 1.4158E-40 277810000 146680000 131130000 914 IPI:IPI00010860.1;IPI:IPI00216220.1 26S proteasome non-ATPase regulatory subunit 9;26S proteasome regulatory subunit p27 PSMD9 O00233-1;O00233;O00233-2 ENST00000261817;ENST00000340175 K06693 2 0.82021 1.6483 0.72568 1.1025 1.0409 0.9829 HMA cell part;cytoplasmic part;cytosol;intracellular part binding;cation binding;copper chaperone activity;copper ion binding;copper-dependent protein binding;ion binding;metal ion binding;metallochaperone activity;protein binding;transition metal ion binding cation transport;cellular copper ion homeostasis;cellular homeostasis;cellular ion homeostasis;cellular process;copper ion transport;ion transport;metal ion transport;response to oxidative stress;response to stress;transition metal ion transport;transport 6 6 6 73.5 73.5 73.5 7.4016 3.1937E-81 189380000 102550000 86827000 915 IPI:IPI00010863.5 Copper transport protein ATOX1;Metal transport protein ATX1 ATOX1;HAH1 O00244 ENST00000313115 1 0.81504 1.4991 0.81584 1.0639 1.0659 1.0362 CK_II_beta cell part;intracellular part;macromolecular complex;protein complex;protein kinase CK2 complex binding;catalytic activity;kinase activity;protein binding;protein kinase activity;protein serine/threonine kinase activity;transferase activity;transferase activity, transferring phosphorus-containing groups biological regulation;cell communication;cell surface receptor linked signal transduction;cellular process;regulation of biological process;regulation of cellular process;signal transduction;Wnt receptor signaling pathway Adherens junction;Circadian rhythm - plant;Tight junction;Wnt signaling pathway 7 7 7 41.4 41.4 41.4 24.942 7.6812E-163 1680000000 1288900000 391070000 916 IPI:IPI00010865.1 Casein kinase II subunit beta;Phosvitin;G5a CSNK2B;CK2N;G5A P67870 ENST00000375865;ENST00000375866;ENST00000375882;ENST00000375885;ENST00000383241;ENST00000383244;ENST00000383427;ENST00000383433;ENST00000400070;ENST00000400076;ENST00000400110;ENST00000400116 K03115 1 1.0667 1.3244 1.5441 1.3697 0.95079 1.7774 Chromo cell part;chromatin;chromosomal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;nucleus;organelle;organelle part binding;chromatin binding;protein binding;transcription cofactor activity;transcription corepressor activity;transcription factor binding;transcription regulator activity;transcription repressor activity anti-apoptosis;chromatin assembly or disassembly;chromatin organization;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;proteolysis;regulation of transcription, DNA-dependent;transcription 3 3 3 6.4 6.4 6.4 61.509 4.9916E-07 87513000 26771000 60742000 917 IPI:IPI00010872.3 E3 SUMO-protein ligase CBX4;Chromobox protein homolog 4;Polycomb 2 homolog CBX4 O00257 ENST00000269397;ENST00000343048 K11452 1 1.1299 1.9046 1.1285 1.4351 1.3743 1.4556 CIDE-N;DFF-C cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;caspase-activated deoxyribonuclease activity;catalytic activity;deoxyribonuclease activity;hydrolase activity;hydrolase activity, acting on ester bonds;identical protein binding;nuclease activity;protein binding DNA catabolic process;DNA catabolic process, endonucleolytic;DNA fragmentation involved in apoptosis;DNA metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Apoptosis 8 8 8 28.1 28.1 28.1 36.521 1.9158E-128 486300000 233680000 252620000 919 IPI:IPI00010882.3;IPI:IPI00604566.3 DNA fragmentation factor subunit alpha;DNA fragmentation factor 45 kDa subunit;Inhibitor of CAD DFFA;DFF1;DFF45;H13 O00273-1;O00273;O00273-2 ENST00000377036;ENST00000377038 K02310 2 0.76577 1.4283 0.74179 0.99135 0.95529 0.96016 brush border;cell fraction;cell projection;insoluble fraction;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane fraction;membrane part;nuclear membrane;organelle membrane;organelle part;plasma membrane;soluble fraction anion channel activity;anion transmembrane transporter activity;binding;chloride channel activity;ion channel activity;transporter activity;voltage-gated anion channel activity;voltage-gated chloride channel activity;voltage-gated ion channel activity anion transport;cell communication;cellular process;chloride transport;establishment of localization;inorganic anion transport;ion transport;regulation of biological process;regulation of cellular process;signal transduction;transport 12 12 12 61.8 61.8 61.8 26.922 3.9803E-283 2591700000 1381400000 1210300000 921 IPI:IPI00010896.3 Chloride intracellular channel protein 1;Nuclear chloride ion channel 27;Chloride channel ABP;Regulatory nuclear chloride ion channel protein CLIC1;NCC27 O00299 ENST00000211475;ENST00000375779;ENST00000375780;ENST00000375784;ENST00000383218;ENST00000383404;ENST00000383405;ENST00000395892;ENST00000400021;ENST00000400022;ENST00000400052;ENST00000400058 K05021 1 1.2536 2.5503 1.1461 1.6695 1.5867 1.5566 SPRY;zf-B_box;zf-C3HC4 binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transition metal ion binding;zinc ion binding 8 8 8 19.3 19.3 19.3 62.165 1.0141E-44 70584000 37070000 33514000 922 IPI:IPI00010948.2 Tripartite motif-containing protein 26;Zinc finger protein 173;Acid finger protein;RING finger protein 95 TRIM26;RNF95;ZNF173 Q12899 ENST00000327357;ENST00000354738;ENST00000383465;ENST00000383466;ENST00000383607;ENST00000383608;ENST00000396558;ENST00000400608;ENST00000400648 K12008 1 0.75337 1.748 NaN 1.0201 1.1629 NaN DUF303 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;lysosome;lytic vacuole;membrane-bounded organelle;organelle;vacuole acetylesterase activity;carboxylesterase activity;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;short-chain carboxylesterase activity;sialate O-acetylesterase activity 2 2 2 5.5 5.5 5.5 58.314 1.2001E-07 8244100 4681200 3562900 923 IPI:IPI00010949.3;IPI:IPI00759728.1 Sialate O-acetylesterase;Sialic acid-specific 9-O-acetylesterase;H-Lse SIAE;YSG2 Q9HAT2-1;Q9HAT2;Q9HAT2-2 ENST00000263593 K05970 2 0.89187 18.548 0.91844 1.0872 13.35 1.1544 Plectin cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle binding;protein binding;structural molecule activity + 5 2 2 5.2 0.6 0.6 555.61 4.7259E-41 1871500000 1705400000 166130000 924 IPI:IPI00010951.2 Epiplakin;450 kDa epidermal antigen EPPK1;EPIPL P58107 1 0.31356 0.55134 NaN 0.39 0.38563 NaN UDG cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;nucleus;organelle binding;catalytic activity;DNA N-glycosylase activity;hydrolase activity;hydrolase activity, acting on glycosyl bonds;hydrolase activity, hydrolyzing N-glycosyl compounds;protein binding;uracil DNA N-glycosylase activity base-excision repair;cellular process;DNA metabolic process;DNA repair;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to DNA damage stimulus;response to stress Base excision repair;Primary immunodeficiency 4 4 1 19.5 19.5 3.8 34.645 2.7774E-18 51993000 29086000 22906000 925 IPI:IPI00011069.1 Uracil-DNA glycosylase UNG;DGU;UNG1;UNG15 P13051-1;P13051 ENST00000242576;ENST00000336865 K03648 1 0.68791 1.3729 0.64508 0.91975 0.88088 0.83665 macromolecular complex;membrane;mitochondrial inner membrane;mitochondrial membrane;mitochondrial ribosome;non-membrane-bounded organelle;organellar ribosome;organelle;organelle inner membrane;organelle membrane;ribonucleoprotein complex;ribosome structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 3 3 3 12.3 12.3 12.3 22.913 9.6562E-19 52390000 30666000 21724000 926 IPI:IPI00011077.4 39S ribosomal protein L32, mitochondrial;MRP-L32 MRPL32;HSPC283 Q9BYC8 ENST00000223324 1 0.7762 1.6244 0.77969 1.0251 1.079 1.0345 Iso_dh cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle binding;catalytic activity;isocitrate dehydrogenase (NADP+) activity;isocitrate dehydrogenase activity;magnesium ion binding;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors acetyl-CoA metabolic process;carbohydrate metabolic process;cellular aldehyde metabolic process;coenzyme metabolic process;glyoxylate cycle;isocitrate metabolic process;metabolic process;organic acid metabolic process;tricarboxylic acid cycle Citrate cycle (TCA cycle);Glutathione metabolism;Reductive carboxylate cycle (CO2 fixation) 20 20 19 43.1 43.1 43.1 50.909 0 2476100000 1322300000 1153800000 927 IPI:IPI00011107.2 Isocitrate dehydrogenase [NADP], mitochondrial;Oxalosuccinate decarboxylase;NADP(+)-specific ICDH;IDP;ICD-M IDH2 P48735 ENST00000330062 K00031 1 0.77859 1.6021 0.7656 1.0289 1.047 1.0401 AAA cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;proteasome complex;protein complex ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Proteasome 20 20 20 49.3 49.3 49.3 49.184 2.7629E-190 2922500000 1278500000 1644100000 930 IPI:IPI00011126.6 26S protease regulatory subunit 4;P26s4;Proteasome 26S subunit ATPase 1 PSMC1 P62191 ENST00000261303 K03062 1 0.91719 1.7712 0.81519 1.2 1.2008 1.039 TBC cell projection;cytoplasm;cytoskeleton;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;microvillus;non-membrane-bounded organelle;nucleus;organelle binding;enzyme activator activity;enzyme regulator activity;GTPase activator activity;PDZ domain binding;protein binding;protein domain specific binding;Rab GTPase activator activity;Ras GTPase activator activity;small GTPase regulator activity biological regulation;regulation of catalytic activity;regulation of GTPase activity;regulation of hydrolase activity;regulation of molecular function;regulation of Rab GTPase activity;regulation of Ras GTPase activity 3 3 3 5.7 5.7 5.7 57.117 3.2719E-06 28480000 14506000 13974000 931 IPI:IPI00011167.1 TBC1 domain family member 10A;EBP50-PDX interactor of 64 kDa TBC1D10A;EPI64;TBC1D10 Q9BXI6 ENST00000215790;ENST00000403477 1 0.88805 1.6012 0.94836 1.1407 1.0892 1.1987 2-Hacid_dh;2-Hacid_dh_C binding;catalytic activity;electron carrier activity;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;phosphoglycerate dehydrogenase activity brain development;cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;L-serine biosynthetic process;L-serine metabolic process;metabolic process;nitrogen compound metabolic process;organic acid metabolic process Glycine, serine and threonine metabolism 27 27 27 50.8 50.8 50.8 56.65 0 13463000000 6824700000 6638300000 932 IPI:IPI00011200.5 D-3-phosphoglycerate dehydrogenase PHGDH;PGDH3 O43175 ENST00000369409 K00058 1 0.92129 1.79 0.97555 1.1961 1.2291 1.2362 malic;Malic_M cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part binding;catalytic activity;electron carrier activity;malate dehydrogenase (decarboxylating) activity;malate dehydrogenase activity;malic enzyme activity;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors carboxylic acid metabolic process;cellular ketone metabolic process;cellular metabolic process;cellular process;dicarboxylic acid metabolic process;malate metabolic process;metabolic process;organic acid metabolic process;oxoacid metabolic process Pyruvate metabolism;Two-component system 32 32 32 61.3 61.3 61.3 65.443 0 3006700000 1540100000 1466600000 933 IPI:IPI00011201.1;IPI:IPI00003970.2 NAD-dependent malic enzyme, mitochondrial;Malic enzyme 2 ME2 P23368 ENST00000321341 K00027 2 0.90825 1.6557 0.91919 1.1409 1.0998 1.1546 ETC_C1_NDUFA4 cytoplasmic part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;mitochondrial membrane part;mitochondrial part;mitochondrial respiratory chain complex I;NADH dehydrogenase complex;organelle part;protein complex catalytic activity;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor cell communication;generation of precursor metabolites and energy;mitochondrial electron transport, NADH to ubiquinone;oxygen and reactive oxygen species metabolic process;protein complex assembly;regulation of protein amino acid phosphorylation;transport Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 3 3 3 20.6 20.6 20.6 20.108 2.4655E-14 27438000 13819000 13619000 934 IPI:IPI00011217.3 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial;NADH-ubiquinone oxidoreductase 18 kDa subunit;Complex I-18 kDa;Complex I-AQDQ NDUFS4 O43181 ENST00000296684 K03937 1 0.97624 2.0501 0.9522 1.2362 1.3502 1.2481 A1_Propeptide;Asp cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;extracellular region;intracellular membrane-bounded organelle;intracellular organelle;lysosome;lytic vacuole;melanosome;membrane-bounded organelle;membrane-bounded vesicle;organelle;vacuole;vesicle aspartic-type endopeptidase activity;aspartic-type peptidase activity;catalytic activity;endopeptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis 15 15 15 36.4 36.4 36.4 44.552 3.2176E-264 1469500000 777960000 691560000 935 IPI:IPI00011229.1 Cathepsin D;Cathepsin D light chain;Cathepsin D heavy chain CTSD;CPSD P07339 ENST00000236671;ENST00000407742 K01379 1 0.74299 1.512 0.75811 1.0227 1.0125 1.0033 Peptidase_C12 cell part;cytoplasm;intracellular part catalytic activity;cysteine-type peptidase activity;hydrolase activity;hydrolase activity, acting on ester bonds;peptidase activity;peptidase activity, acting on L-amino acid peptides;thiolester hydrolase activity;ubiquitin thiolesterase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process 12 12 12 62.2 62.2 62.2 26.182 2.2292E-186 1270200000 570210000 699980000 936 IPI:IPI00011250.3 Ubiquitin carboxyl-terminal hydrolase isozyme L3;Ubiquitin thioesterase L3 UCHL3 P15374 ENST00000377589;ENST00000377595 K05609 1 0.72134 1.3971 0.71228 0.92674 0.90697 0.92893 KH_2;Ribosomal_S3_C cell projection membrane;cytosolic small ribosomal subunit;leading edge membrane;macromolecular complex;membrane-bounded organelle;nucleus;organelle;ribonucleoprotein complex;ribosomal subunit;ruffle membrane;small ribosomal subunit catalytic activity;damaged DNA binding;DNA binding;DNA-(apurinic or apyrimidinic site) lyase activity;endonuclease activity;mRNA binding;nuclease activity;nucleic acid binding;RNA binding;structural constituent of ribosome;structural molecule activity activation of caspase activity;biosynthetic process;induction of apoptosis;macromolecule biosynthetic process;metabolic process;regulation of DNA repair;response to DNA damage stimulus;response to stress;translational elongation;translational initiation Ribosome 27 27 27 78.6 78.6 78.6 26.688 0 9149600000 4224900000 4924700000 937 IPI:IPI00011253.3 40S ribosomal protein S3 RPS3;OK/SW-cl.26 P23396 ENST00000278572;ENST00000405680 K02985 1 0.85507 1.5375 0.82357 1.121 1.0185 1.0391 RRM_1 cell part;heterogeneous nuclear ribonucleoprotein complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;nucleotide binding;RNA binding cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 11 11 11 52.1 52.1 52.1 32.55 1.9392E-175 1924600000 1011600000 913010000 938 IPI:IPI00011268.2;IPI:IPI00216044.1 RNA-binding protein Raly;hnRNP associated with lethal yellow homolog;Autoantigen p542;Heterogeneous nuclear ribonucleoprotein C-like 2 RALY;HNRPCL2;P542 Q9UKM9-1;Q9UKM9;Q9UKM9-2 ENST00000246194;ENST00000375114 2 0.65522 1.3075 0.67296 0.9089 0.84594 0.94722 RRM_1 cell part;cytoplasm;heterogeneous nuclear ribonucleoprotein complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex binding;DNA binding;double-stranded DNA binding;mRNA binding;nucleic acid binding;nucleotide binding;poly(A) RNA binding;protein binding;RNA binding;single-stranded DNA binding;single-stranded RNA binding;structure-specific DNA binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;RNA processing;transcription 15 14 14 32.4 30.5 30.5 46.437 0 1570300000 821070000 749260000 939 IPI:IPI00011274.3;IPI:IPI00845282.1;IPI:IPI00045498.4 Heterogeneous nuclear ribonucleoprotein D-like;JKT41-binding protein;AU-rich element RNA-binding factor;Protein laAUF1 HNRPDL;JKTBP O14979-1;O14979;O14979-2;O14979-3 ENST00000295470;ENST00000349655 3 0.7167 1.3857 0.72253 0.93646 0.96144 0.96983 Transket_pyr;Transketolase_C cytoplasmic part;intracellular organelle part;intracellular part;macromolecular complex;mitochondrial alpha-ketoglutarate dehydrogenase complex;mitochondrial part;mitochondrial tricarboxylic acid cycle enzyme complex;organelle part;protein complex 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity;binding;catalytic activity;lyase activity;oxidoreductase activity;oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor;protein binding catabolic process;cellular amino acid and derivative metabolic process;cellular amino acid catabolic process;cellular amino acid metabolic process;metabolic process;nitrogen compound metabolic process;organic acid metabolic process Valine, leucine and isoleucine degradation 7 7 7 21.4 21.4 21.4 43.122 4.3949E-163 26051000 13707000 12344000 940 IPI:IPI00011276.1 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial;Branched-chain alpha-keto acid dehydrogenase E1 component beta chain BCKDHB P21953 ENST00000320393;ENST00000356489 K00167 1 0.71762 1.5718 0.59994 0.94891 1.0535 0.88466 Methyltransf_3 cell fraction;cytosol;insoluble fraction;integral to membrane;intracellular organelle;intrinsic to membrane;membrane;membrane fraction;membrane-bounded organelle;microsome;organelle;plasma membrane;soluble fraction;vesicular fraction binding;catalytic activity;catechol O-methyltransferase activity;magnesium ion binding;methyltransferase activity;O-methyltransferase activity;protein binding;S-adenosylmethionine-dependent methyltransferase activity;transferase activity biological regulation;catabolic process;cellular catabolic process;cellular metabolic process;cellular process;metabolic process;neurotransmitter catabolic process;neurotransmitter metabolic process;regulation of neurotransmitter levels Tyrosine metabolism 12 12 12 60.1 60.1 60.1 30.037 0 274730000 141940000 132790000 941 IPI:IPI00011284.1;IPI:IPI00375513.3 Catechol O-methyltransferase COMT P21964-1;P21964;P21964-2 ENST00000207636;ENST00000402871;ENST00000403710;ENST00000406520;ENST00000407537 K00545 2 0.75049 1.4331 0.7788 0.95499 0.96427 0.99733 Calpain_III;Peptidase_C2 cell part;cytoplasm;intracellular part;membrane;plasma membrane binding;calcium ion binding;calcium-dependent cysteine-type endopeptidase activity;catalytic activity;cysteine-type endopeptidase activity;cysteine-type peptidase activity;endopeptidase activity;hydrolase activity;peptidase activity;protein binding catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;positive regulation of cell proliferation;protein catabolic process;protein metabolic process;proteolysis;regulation of cell proliferation Alzheimer's disease;Apoptosis 27 27 27 39.5 39.5 39.5 81.889 8.9439E-263 1323000000 659010000 664010000 942 IPI:IPI00011285.1 Calpain-1 catalytic subunit;Calpain-1 large subunit;Calcium-activated neutral proteinase 1;Calpain mu-type;muCANP;Micromolar-calpain;Cell proliferation-inducing gene 30 protein CAPN1;CANPL1;PIG30 P07384 ENST00000279247 K01367 1 1.0776 2.1645 1.1463 1.5008 1.3998 1.3935 UPAR_LY6 anchored to external side of plasma membrane;anchored to membrane;cell fraction;extracellular region;insoluble fraction;intrinsic to external side of plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane fraction;membrane part binding;protein binding blood coagulation;cell communication;cell surface receptor linked signal transduction;cellular process;coagulation;hemostasis;multicellular organismal process;regulation of biological process;regulation of cellular process;signal transduction Complement and coagulation cascades;Hematopoietic cell lineage 4 4 4 21.9 21.9 21.9 14.177 5.4625E-61 416860000 195110000 221750000 943 IPI:IPI00011302.1 CD59 glycoprotein;Membrane attack complex inhibition factor;MAC-inhibitory protein;Protectin;MEM43 antigen;Membrane inhibitor of reactive lysis;20 kDa homologous restriction factor;HRF-20;1F5 antigen CD59;MIC11;MIN1;MIN2;MIN3;MSK21 P13987 ENST00000351554;ENST00000395850 K04008 1 0.80408 1.247 0.8514 0.99102 0.86761 1.0104 THF_DHG_CYH;THF_DHG_CYH_C cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle catalytic activity;magnesium ion binding;methenyltetrahydrofolate cyclohydrolase activity;methylenetetrahydrofolate dehydrogenase (NAD+) activity;methylenetetrahydrofolate dehydrogenase (NADP+) activity;methylenetetrahydrofolate dehydrogenase activity cellular aromatic compound metabolic process;coenzyme metabolic process;folic acid and derivative metabolic process;group transfer coenzyme metabolic process;nitrogen compound metabolic process;one-carbon metabolic process;organic acid metabolic process 7 7 7 26.6 26.6 26.6 37.895 7.5695E-137 673340000 325610000 347730000 944 IPI:IPI00011307.4 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial;NAD-dependent methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase MTHFD2;NMDMC P13995 ENST00000394053 1 0.92435 1.4545 0.92442 1.1658 1.0161 1.1412 ECH cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;microbody;mitochondrion;organelle;peroxisome binding;carbon-oxygen lyase activity;catalytic activity;enoyl-CoA hydratase activity;hydro-lyase activity;isomerase activity;lyase activity;protein binding catabolic process;cellular process;fatty acid beta-oxidation;fatty acid catabolic process;fatty acid metabolic process;generation of precursor metabolites and energy;lipid metabolic process;metabolic process;organic acid metabolic process Tyrosine metabolism 12 12 12 44.2 44.2 44.2 35.816 3.4706E-281 1848900000 942210000 906740000 945 IPI:IPI00011416.2 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial ECH1 Q13011 ENST00000221418 K01828 1 NaN 4.1885 NaN NaN 2.8725 NaN 2 2 2 31.1 31.1 31.1 10.061 2.2926E-32 258310 116460 141840 946 IPI:IPI00011421.1 Protein AF1q MLLT11;AF1Q Q13015 ENST00000368921 1 0.94399 1.6804 0.93405 1.2308 1.1256 1.1867 Glyco_hydro_31 cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;endoplasmic reticulum;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;melanosome;membrane-bounded organelle;membrane-bounded vesicle;organelle;vesicle binding;catalytic activity;glucan 1,3-alpha-glucosidase activity;hydrolase activity;hydrolase activity, acting on glycosyl bonds;hydrolase activity, hydrolyzing O-glycosyl compounds;protein binding carbohydrate metabolic process;metabolic process;primary metabolic process N-Glycan biosynthesis 33 33 1 38.2 38.2 1.1 109.44 0 5677100000 2986300000 2690800000 947 IPI:IPI00011454.1 Neutral alpha-glucosidase AB;Glucosidase II subunit alpha;Alpha-glucosidase 2 GANAB;G2AN;KIAA0088 Q14697-2;Q14697 ENST00000346178;ENST00000356638 K05546 1 1.0882 1.9954 0.95364 1.3914 1.3708 1.1317 Striatin;WD40 cell fraction;cytoskeleton;cytosol;insoluble fraction;intracellular membrane-bounded organelle;intracellular organelle;membrane;membrane fraction;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle binding;calmodulin binding;protein binding cell cycle;cellular process 9 9 9 16.9 16.9 16.9 87.208 2.7209E-106 283230000 145350000 137880000 948 IPI:IPI00011461.5;IPI:IPI00477001.3 Striatin-3;Cell-cycle autoantigen SG2NA;S/G2 antigen STRN3;GS2NA;SG2NA Q13033-1;Q13033;Q13033-2 ENST00000355683;ENST00000357479 2 0.92885 1.5403 0.85072 1.2692 1.0389 1.1351 Pkinase cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;kinase activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transcription factor binding apoptosis;cell communication;cell morphogenesis;intracellular signaling cascade;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein kinase cascade;protein modification process;signal transduction MAPK signaling pathway;Non-small cell lung cancer;Pathways in cancer 29 29 22 53.2 53.2 38.6 55.63 0 746480000 378180000 368300000 949 IPI:IPI00011488.4;IPI:IPI00645585.2 Serine/threonine-protein kinase 4;STE20-like kinase MST1;Mammalian STE20-like protein kinase 1;Serine/threonine-protein kinase Krs-2 STK4;MST1 Q13043-1;Q13043;Q13043-2 ENST00000372806;ENST00000396731 K04411 2 0.69882 1.3522 0.73105 0.90948 0.92888 0.9171 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle catalytic activity;hydrolase activity metabolic process 11 11 11 41.6 41.6 41.6 46.321 0 681180000 359540000 321640000 950 IPI:IPI00011511.1;IPI:IPI00299177.4 Cat eye syndrome critical region protein 5 CECR5 Q9BXW7-1;Q9BXW7;Q9BXW7-2 ENST00000155674;ENST00000336737 2 0.81042 1.2992 0.76904 1.0026 0.91233 0.96287 WD40 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;protein binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 12 12 12 40.6 40.6 40.6 48.357 3.6839E-244 195210000 104620000 90592000 952 IPI:IPI00011528.1 Cleavage stimulation factor 50 kDa subunit;CF-1 50 kDa subunit;CstF-50 CSTF1 Q05048 ENST00000217109 1 1.5263 0.3065 2.0846 1.9425 0.21118 2.5535 zf-CCHC binding;cation binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding 6 6 5 15.8 15.8 14.4 43.618 1.7448E-50 10796000 5344200 5452200 953 IPI:IPI00011550.1 Zinc finger CCHC domain-containing protein 3 ZCCHC3;C20orf99 Q9NUD5 ENST00000382352 1 0.64289 1.3852 0.66346 0.94941 0.84659 0.97605 SPRY;zf-B_box;zf-C3HC4 cell part;cytoplasm;intracellular part binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding anatomical structure formation;cellular component assembly;cellular component organization;macromolecular complex assembly;macromolecular complex subunit organization;protein complex assembly;protein oligomerization;protein trimerization 3 3 3 8 8 8 57.46 3.789E-06 4576600000 2470900000 2105600000 954 IPI:IPI00030371.2;IPI:IPI00011551.1;IPI:IPI00410582.3 Tripartite motif-containing protein 4;RING finger protein 87 TRIM4;RNF87 Q9C037-1;Q9C037;Q9C037-2;Q9C037-3 ENST00000349062;ENST00000354241;ENST00000355947 K11998 3 0.33902 0.74244 0.32947 0.46147 0.47102 0.42695 ACC_central;Biotin_carb_C;Biotin_lipoyl;Carboxyl_trans;CPSase_L_chain;CPSase_L_D2 cell part;cytoplasm;intracellular part acetyl-CoA carboxylase activity;ATP binding;binding;biotin binding;biotin carboxylase activity;catalytic activity;CoA carboxylase activity;ligase activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding biosynthetic process;cellular process;fatty acid biosynthetic process;fatty acid metabolic process;lipid biosynthetic process;lipid metabolic process;metabolic process;organic acid biosynthetic process;organic acid metabolic process Fatty acid biosynthesis;Insulin signaling pathway;Propanoate metabolism;Pyruvate metabolism 27 27 27 14.5 14.5 14.5 270 1.4254E-242 213890000 126150000 87735000 955 IPI:IPI00396015.5;IPI:IPI00011569.2;IPI:IPI00847501.1;IPI:IPI00396018.1;IPI:IPI00013003.2;IPI:IPI00157056.6 Acetyl-CoA carboxylase 1;ACC-alpha;Biotin carboxylase ACACA;ACAC;ACC1;ACCA Q13085-4;Q13085;Q13085-1;Q13085-2;Q13085-3 ENST00000335166;ENST00000353139;ENST00000360679;ENST00000361253;ENST00000394406;ENST00000394407 K01946;K11262 6 1.046 1.7952 0.94394 1.371 1.2478 1.1684 I-set cell part;integral to membrane;intrinsic to membrane;membrane;membrane part;plasma membrane;presynaptic membrane;synapse part binding;cell adhesion molecule binding;protein binding biological adhesion;cell adhesion;cell-cell adhesion;cellular process;homophilic cell adhesion;positive regulation of cell development;regulation of cell communication;regulation of neurological system process;regulation of system process 4 4 4 11.6 11.6 11.6 44.387 1.6727E-44 39073000 19986000 19087000 956 IPI:IPI00018311.1;IPI:IPI00654584.6;IPI:IPI00011578.1;IPI:IPI00657724.1 Neuroplastin;Stromal cell-derived receptor 1 NPTN;SDFR1;SDR1 Q9Y639-2;Q9Y639;Q9Y639-4;Q9Y639-1;Q9Y639-3 ENST00000287226;ENST00000345330;ENST00000351217;ENST00000395177;ENST00000404878;ENST00000406430 4 0.7799 1.5864 0.88672 1.0356 1.0295 1.1728 DLIC cell part;cytoplasmic dynein complex;cytoskeletal part;dynein complex;intracellular organelle part;intracellular part;macromolecular complex;microtubule;microtubule associated complex;organelle part;protein complex ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;motor activity;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity 5 4 4 15.2 12.6 12.6 54.099 2.4591E-69 117630000 62603000 55027000 957 IPI:IPI00011592.3 Cytoplasmic dynein 1 light intermediate chain 2;Dynein light intermediate chain 2, cytosolic;LIC53/55 DYNC1LI2;DNCLI2;LIC2 O43237 ENST00000258198 K10416 1 0.84951 1.7525 0.87426 1.1589 1.1466 1.1317 PCI;Rpn3_C cell part;cytoplasmic part;cytosol;intracellular part;macromolecular complex;proteasome complex;protein complex binding;enzyme regulator activity;protein binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;proteasomal protein catabolic process;proteolysis;regulation of catabolic process;regulation of metabolic process;ubiquitin-dependent protein catabolic process Proteasome 30 30 30 54.1 54.1 54.1 60.977 0 3105000000 1614300000 1490700000 958 IPI:IPI00011603.2 26S proteasome non-ATPase regulatory subunit 3;Proteasome subunit p58 PSMD3 O43242 ENST00000264639 K03033 1 0.66672 1.349 0.66004 0.87725 0.87595 0.87335 GCV_H cell part;cytoplasmic part;glycine cleavage complex;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;mitochondrion;organelle;protein complex aminomethyltransferase activity;binding;carboxylic acid binding;catalytic activity;coenzyme binding;cofactor binding;lipoic acid binding;methyltransferase activity;transferase activity;transferase activity, transferring one-carbon groups catabolic process;cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;glycine catabolic process;glycine metabolic process;metabolic process;nitrogen compound metabolic process;organic acid metabolic process 2 2 2 9.8 9.8 9.8 18.91 3.2471E-05 162810000 85908000 76899000 959 IPI:IPI00011604.1 Glycine cleavage system H protein, mitochondrial GCSH P23434 ENST00000315467 1 0.71847 1.3417 0.76157 0.9796 0.89568 1.0191 HECT cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;protein complex binding;protein binding brain development;catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Ubiquitin mediated proteolysis 20 20 20 27.9 27.9 27.9 100.69 0 310840000 162290000 148560000 960 IPI:IPI00011609.4;IPI:IPI00219198.2;IPI:IPI00219197.3 Ubiquitin-protein ligase E3A;E6AP ubiquitin-protein ligase;Oncogenic protein-associated protein E6-AP;Human papillomavirus E6-associated protein;Renal carcinoma antigen NY-REN-54 UBE3A;E6AP;EPVE6AP;HPVE6A Q05086-1;Q05086;Q05086-3;Q05086-2 ENST00000232165;ENST00000397954 K10587 3 0.76876 1.3991 0.68155 1.0089 0.87012 0.93731 APS_kinase;ATP-sulfurylase adenylylsulfate kinase activity;ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;sulfate adenylyltransferase (ATP) activity;sulfate adenylyltransferase activity;transferase activity anatomical structure development;cellular metabolic process;cellular process;developmental process;metabolic process;skeletal system development;sulfate assimilation;sulfur metabolic process;sulfur utilization;system development Purine metabolism;Selenoamino acid metabolism;Sulfur metabolism 20 20 20 44.1 44.1 44.1 70.832 9.4663E-161 435210000 238170000 197040000 961 IPI:IPI00011619.4;IPI:IPI00220873.1;IPI:IPI00030009.4 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1;Sulfurylase kinase 1;Sulfate adenylyltransferase;Sulfate adenylate transferase;ATP-sulfurylase;Adenylyl-sulfate kinase;Adenylylsulfate 3'-phosphotransferase;APS kinase;Adenosine-5'-phosphosulfate 3'-phosphotransferase;3'-phosphoadenosine-5'-phosphosulfate synthetase PAPSS1;ATPSK1;PAPSS O43252 ENST00000265174 K00860;K00958 3 0.71757 1.3533 0.71152 0.974 0.90368 0.95022 Zw10 condensed chromosome kinetochore;endoplasmic reticulum membrane;kinetochore;kinetochore microtubule;macromolecular complex;membrane;membrane-bounded organelle;microtubule;nucleus;organelle;organelle membrane;spindle microtubule;spindle pole binding;centromeric DNA binding;DNA binding;nucleic acid binding;protein binding;sequence-specific DNA binding cell cycle checkpoint;ER to Golgi vesicle-mediated transport;mitotic cell cycle checkpoint;mitotic sister chromatid segregation;organelle organization;protein complex assembly;regulation of mitosis;sister chromatid segregation;transport 19 19 19 29.8 29.8 29.8 88.828 1.8125E-179 338170000 178430000 159730000 962 IPI:IPI00011631.6 Centromere/kinetochore protein zw10 homolog ZW10 O43264 ENST00000200135 K11578 1 0.6549 1.8315 0.79701 0.88679 1.1781 1.0387 Bcl-2 integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane;membrane part;membrane-bounded organelle;mitochondrial membrane;nucleus;organelle;organelle membrane;organelle part apoptotic protease activator activity;caspase activator activity;caspase regulator activity;enzyme activator activity;enzyme regulator activity;peptidase activator activity activation of caspase activity;induction of apoptosis;induction of programmed cell death;positive regulation of apoptosis;positive regulation of cell death;positive regulation of peptidase activity;regulation of apoptosis;regulation of cell death 3 3 3 10.1 10.1 10.1 52.723 1.3191E-45 16309000 9173400 7135700 963 IPI:IPI00011635.3;IPI:IPI00220829.1 Bcl-2-like protein 13;Protein Mil1;Bcl-rambo BCL2L13;MIL1;CD003 Q9BXK5-1;Q9BXK5;Q9BXK5-2 ENST00000317582 2 NaN NaN 0.91356 NaN NaN 1.1476 Kunitz_BPTI;Ldl_recept_a;MANEC cell fraction;cell part;cytoplasm;extracellular region;insoluble fraction;intracellular part;membrane;membrane fraction;plasma membrane binding;endopeptidase inhibitor activity;enzyme inhibitor activity;enzyme regulator activity;peptidase inhibitor activity;protein binding;serine-type endopeptidase inhibitor activity 2 2 2 4.2 4.2 4.2 58.397 0.0013266 2405300 1046200 1359100 964 IPI:IPI00376403.2;IPI:IPI00011643.1 Kunitz-type protease inhibitor 1;Hepatocyte growth factor activator inhibitor type 1 SPINT1;HAI1;UNQ223/PRO256 O43278-1;O43278;O43278-2 ENST00000344051 2 1.0299 1.6217 1.0733 1.3282 1.0696 1.3557 Kunitz_BPTI cell fraction;cell part;cytoplasm;extracellular matrix;extracellular region part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;plasma membrane;soluble fraction endopeptidase inhibitor activity;enzyme inhibitor activity;enzyme regulator activity;peptidase inhibitor activity;serine-type endopeptidase inhibitor activity cell motion;cellular process 3 3 3 11.5 11.5 11.5 28.228 5.6849E-16 20852000 9741300 11111000 966 IPI:IPI00011662.1 Kunitz-type protease inhibitor 2;Hepatocyte growth factor activator inhibitor type 2;Placental bikunin SPINT2;HAI2;KOP O43291 ENST00000301244 1 0.63749 1.2136 0.75411 0.88392 0.80031 0.9442 Alpha_kinase;Sel1 cell part;cytoplasmic part;cytosol;intracellular part calmodulin-dependent protein kinase activity;catalytic activity;elongation factor-2 kinase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein modification process;translational elongation 2 2 2 2.9 2.9 2.9 82.143 0.0016092 8923400 4529300 4394200 967 IPI:IPI00011689.2 Elongation factor 2 kinase;eEF-2 kinase;Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase EEF2K O00418 ENST00000263026 K08292 1 NaN NaN 0.49352 NaN NaN 0.66019 DUF367;RLI cell part;integral to membrane;intrinsic to membrane;membrane part 2 2 2 8.3 8.3 8.3 33.596 7.3951E-46 20593000 11204000 9388700 968 IPI:IPI00011693.4 UPF0293 protein C16orf42 C16orf42;UND313L Q9UJK0 ENST00000007390 K09140 1 0.69056 1.4149 0.70133 0.92294 0.95877 0.89916 C1_1;CH;PH;RhoGEF;SH2;SH3_1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle binding;cation binding;diacylglycerol binding;DNA binding;ion binding;lipid binding;metal ion binding;nucleic acid binding;protein binding;transcription factor activity;transcription regulator activity;transition metal ion binding;zinc ion binding regulation of biological process;regulation of cell communication;regulation of cellular process;regulation of Ras protein signal transduction;regulation of Rho protein signal transduction;regulation of signal transduction B cell receptor signaling pathway;Chemokine signaling pathway;Fc epsilon RI signaling pathway;Focal adhesion;Leukocyte transendothelial migration;Natural killer cell mediated cytotoxicity;Regulation of actin cytoskeleton;T cell receptor signaling pathway 23 23 22 31.8 31.8 30.7 98.313 3.1976E-245 858180000 439720000 418450000 969 IPI:IPI00011696.1 Proto-oncogene vav VAV1;VAV P15498 ENST00000304076 K05730 1 0.43909 0.78123 NaN 0.57878 0.55624 NaN binding 10 10 10 12.6 12.6 12.6 122.07 1.6096E-128 26167000 15067000 11099000 970 IPI:IPI00011702.4 Uncharacterized protein KIAA0406 KIAA0406 O43156 ENST00000373447;ENST00000373448 1 0.86622 1.6563 0.86373 1.1039 1.1465 1.11 RTC;RTC_insert cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part ATP binding;binding;catalytic activity;cyclase activity;ligase activity;ligase activity, forming phosphoric ester bonds;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;RNA binding;RNA-3'-phosphate cyclase activity cellular biopolymer metabolic process;cellular process;macromolecule metabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing 8 8 8 25.6 25.6 25.6 40.709 2.0226E-175 217320000 116840000 100480000 971 IPI:IPI00221327.1;IPI:IPI00011726.1 RNA 3'-terminal phosphate cyclase;RNA terminal phosphate cyclase domain-containing protein 1 RTCD1;RPC;RPC1;RTC1 O00442-2;O00442;O00442-1 ENST00000260563;ENST00000370128 K01974 2 0.77146 1.4362 0.74815 1.0252 0.95655 1.0032 NADH_ub_rd_NUML cytoplasmic part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;mitochondrial membrane part;mitochondrial part;mitochondrial respiratory chain complex I;NADH dehydrogenase complex;organelle part;protein complex catalytic activity;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor cellular metabolic process;cellular process;electron transport chain;generation of precursor metabolites and energy;metabolic process;mitochondrial electron transport, NADH to ubiquinone;respiratory electron transport chain;transport Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 3 3 3 37 37 37 9.3697 2.2525E-19 182720000 95040000 87682000 972 IPI:IPI00011770.1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4;NADH-ubiquinone oxidoreductase MLRQ subunit;Complex I-MLRQ NDUFA4 O00483 ENST00000339600 K03948 1 0.9497 2.0173 NaN 1.2968 1.2342 NaN DUF1055;UCH cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;lysosome;lytic vacuole;membrane-bounded organelle;nucleus;organelle;vacuole binding;catalytic activity;cysteine-type endopeptidase activity;cysteine-type peptidase activity;endopeptidase activity;hydrolase activity;peptidase activity;protein binding;ubiquitin thiolesterase activity;ubiquitin-specific protease activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process 9 7 7 11.5 10.6 10.6 108.56 9.6781E-62 5455300 2673200 2782100 973 IPI:IPI00011836.2;IPI:IPI00216257.2 Ubiquitin carboxyl-terminal hydrolase 4;Ubiquitin thioesterase 4;Ubiquitin-specific-processing protease 4;Deubiquitinating enzyme 4;Ubiquitous nuclear protein homolog USP4;UNP;UNPH Q13107-1;Q13107;Q13107-2 ENST00000265560;ENST00000351842 K11835 2 0.40449 0.5788 0.42019 0.55076 0.39014 0.52692 WD40 cell part;chromatin assembly complex;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex binding;chromatin binding;histone binding;protein binding;unfolded protein binding chromatin assembly or disassembly;chromatin organization;DNA metabolic process;DNA repair;DNA replication;DNA replication-dependent nucleosome assembly;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleosome assembly;transcription 7 7 7 16.1 16.1 16.1 61.492 2.2545E-62 76379000 39975000 36404000 974 IPI:IPI00011857.1 Chromatin assembly factor 1 subunit B;Chromatin assembly factor I p60 subunit;M-phase phosphoprotein 7 CHAF1B;CAF1A;CAF1P60;MPHOSPH7;MPP7 Q13112 ENST00000314103 K10751 1 0.51385 1.0556 0.61723 0.69299 0.68398 0.82512 RED_C;RED_N cell fraction;cell part;extracellular region part;extracellular space;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle;soluble fraction cell communication;cell-cell signaling;cellular process;immune response;immune system process;response to stimulus 10 10 10 23.5 23.5 23.5 65.63 5.19E-31 325230000 176230000 149000000 975 IPI:IPI00011875.1 Protein Red;Protein RER;IK factor;Cytokine IK IK;RED;RER Q13123 ENST00000261812 1 0.58404 1.2642 0.66862 0.76 0.87864 0.86773 Hexapep;W2 cell part;cytoplasmic part;eukaryotic translation initiation factor 2B complex;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;protein complex binding;catalytic activity;enzyme regulator activity;guanyl-nucleotide exchange factor activity;nucleic acid binding;protein binding;transferase activity;translation factor activity, nucleic acid binding;translation initiation factor activity axon ensheathment;ensheathment of neurons;ovarian follicle development;regulation of translation;regulation of translational initiation;response to heat;response to stress;response to temperature stimulus;translational initiation 13 13 13 23.2 23.2 23.2 80.379 1.6507E-175 228140000 116100000 112030000 976 IPI:IPI00011898.3 Translation initiation factor eIF-2B subunit epsilon;eIF-2B GDP-GTP exchange factor subunit epsilon EIF2B5;EIF2BE Q13144 ENST00000273783 K03240 1 0.73803 1.345 0.68934 0.96233 0.87747 0.86025 RRM_1 cell part;heterogeneous nuclear ribonucleoprotein complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex binding;nucleic acid binding;nucleotide binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 10 10 10 45.2 45.2 45.2 30.84 0 911610000 476420000 435200000 977 IPI:IPI00011913.1 Heterogeneous nuclear ribonucleoprotein A0 HNRNPA0;HNRPA0 Q13151 ENST00000314940 1 0.86346 1.4464 0.87479 1.0632 1.0261 1.0782 binding;protein binding biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 9 9 9 33.4 33.4 33.4 35.348 1.387E-90 526800000 271880000 254910000 978 IPI:IPI00011916.1 Aminoacyl tRNA synthetase complex-interacting multifunctional protein 2;Multisynthetase complex auxiliary component p38;Protein JTV-1 AIMP2;JTV1;PRO0992 Q13155 ENST00000223029 1 0.88128 1.4773 0.96965 1.1112 1.0015 1.1775 Death;DED cytoplasmic part;cytosol;death-inducing signaling complex;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane part;membrane-bounded organelle;nucleus;organelle;protein complex binding;cytokine receptor binding;death receptor binding;identical protein binding;protein binding;receptor binding;tumor necrosis factor receptor superfamily binding activation of pro-apoptotic gene products;cell communication;cell death;induction of apoptosis;induction of apoptosis by extracellular signals;induction of apoptosis via death domain receptors;regulation of signal transduction;signal transduction Alzheimer's disease;Apoptosis;Pathways in cancer;Toll-like receptor signaling pathway 6 6 6 45.7 45.7 45.7 23.279 0 117090000 60898000 56196000 979 IPI:IPI00011919.1 Protein FADD;FAS-associated death domain protein;FAS-associating death domain-containing protein;Mediator of receptor induced toxicity;Growth-inhibiting gene 3 protein FADD;MORT1;GIG3 Q13158 ENST00000301838 K02373 1 0.617 1.0813 NaN 0.83339 0.73628 NaN centrosome;cytoplasmic part;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;microtubule organizing center;non-membrane-bounded organelle;organelle;organelle part binding;protein binding cellular component organization;cellular process;centrosome duplication;centrosome organization;microtubule organizing center organization;organelle organization;regulation of biological process;regulation of cellular process;regulation of cytokinesis 5 5 5 6.4 6.4 6.4 113.42 5.593E-46 2502300 1424900 1077400 980 IPI:IPI00011933.3;IPI:IPI00478736.2 Centrosomal protein of 110 kDa CEP110;CP110;KIAA0419 O43303-1;O43303;O43303-2 ENST00000219827;ENST00000381396;ENST00000396208 2 0.80431 1.4186 0.76804 1.001 0.9965 0.97239 1-cysPrx_C;AhpC-TSA antioxidant activity;catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on peroxide as acceptor;peroxidase activity;peroxiredoxin activity;thioredoxin peroxidase activity cellular homeostasis;cellular process;I-kappaB phosphorylation;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process 13 11 11 62.4 57.9 57.9 30.54 2.3581E-290 855840000 447090000 408750000 981 IPI:IPI00011937.1 Peroxiredoxin-4;Prx-IV;Thioredoxin peroxidase AO372;Thioredoxin-dependent peroxide reductase A0372;Antioxidant enzyme AOE372 PRDX4 Q13162 ENST00000379341 K03386 1 0.90154 1.3088 1.0645 1.2241 0.93423 1.4235 MIF4G binding;protein binding cellular biopolymer metabolic process;cellular process;macromolecule metabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process 2 2 2 3.1 3.1 3.1 72.114 0.00037517 9874600 5286700 4587900 982 IPI:IPI00902575.1;IPI:IPI00011951.2;IPI:IPI00604690.1 Uncharacterized protein KIAA0427 KIAA0427 O43310-3;O43310;O43310-2;O43310-1 ENST00000256413;ENST00000382998 3 0.82499 1.8026 0.95639 1.0555 1.1557 1.179 adh_short cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part;plasma membrane binding;catalytic activity;estradiol 17-beta-dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;steroid dehydrogenase activity biosynthetic process;cellular biosynthetic process;cellular metabolic process;cellular process;lipid biosynthetic process;lipid metabolic process;metabolic process;primary metabolic process;steroid biosynthetic process;steroid metabolic process Androgen and estrogen metabolism;Biosynthesis of steroids 5 5 5 18.8 18.8 18.8 38.206 4.4066E-40 74979000 38206000 36773000 983 IPI:IPI00011970.3;IPI:IPI00220886.1;IPI:IPI00807691.2 3-keto-steroid reductase;Estradiol 17-beta-dehydrogenase 7;17-beta-hydroxysteroid dehydrogenase 7 HSD17B7;UNQ2563/PRO6243 P56937-1;P56937;P56937-2;P56937-3 ENST00000254521;ENST00000367917 K00044;K09827 3 1.0757 1.8379 1.0665 1.392 1.2432 1.359 UQ_con cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle acid-amino acid ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleoside binding;nucleotide binding;purine nucleoside binding;ubiquitin-protein ligase activity apoptosis;catabolic process;cell death;cellular process;death;macromolecule catabolic process;metabolic process;programmed cell death;protein metabolic process;protein modification process;proteolysis;regulation of metabolic process Ubiquitin mediated proteolysis 3 3 3 10.2 10.2 10.2 38.21 1.3121E-13 54302000 27010000 27291000 985 IPI:IPI00011996.5;IPI:IPI00829749.1 Ubiquitin-conjugating enzyme E2 Z;Ubiquitin-protein ligase Z;Ubiquitin carrier protein Z;Uba6-specific E2 conjugating enzyme 1 UBE2Z;HOYS7 Q9H832-1;Q9H832;Q9H832-2 ENST00000360943;ENST00000389608 K10585 2 0.7609 1.3443 0.81428 0.9456 0.94831 0.9843 4 4 4 24 24 24 26.448 5.4366E-89 41507000 19846000 21662000 986 IPI:IPI00867735.1;IPI:IPI00011997.4 UPF0488 protein C8orf33 C8orf33 Q9H7E9-2;Q9H7E9;Q9H7E9-1 ENST00000331434 2 0.7158 1.3885 0.72318 0.9454 0.92248 0.93627 AdoHcyase;AdoHcyase_NAD cell part;cytoplasmic membrane-bounded vesicle;cytoplasmic part;cytoplasmic vesicle;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;melanosome;membrane-bounded organelle;membrane-bounded vesicle;organelle;vesicle adenosylhomocysteinase activity;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ether bonds;protein binding;trialkylsulfonium hydrolase activity cellular metabolic process;cellular process;metabolic process;one-carbon metabolic process Methionine metabolism;Selenoamino acid metabolism 30 30 30 52.8 52.8 52.8 47.716 0 5739600000 3110200000 2629500000 987 IPI:IPI00012007.6 Adenosylhomocysteinase;S-adenosyl-L-homocysteine hydrolase AHCY;SAHH P23526 ENST00000217426 K01251 1 0.75819 1.6612 0.79241 1.0662 1.0105 1.1122 Cofilin_ADF cell part;intracellular organelle part;intracellular part;nuclear matrix;nuclear part;organelle part actin binding;binding;cytoskeletal protein binding;protein binding anti-apoptosis;cell communication;cellular process;intracellular signaling cascade;Ras protein signal transduction;regulation of cell death;Rho protein signal transduction;signal transduction;small GTPase mediated signal transduction Axon guidance;Regulation of actin cytoskeleton 23 23 22 85.5 85.5 78.9 18.502 0 18455000000 9701900000 8752900000 988 IPI:IPI00012011.6;IPI:IPI00413344.3 Cofilin-1;Cofilin, non-muscle isoform;18 kDa phosphoprotein;p18 CFL1;CFL P23528 ENST00000308162 K05765 2 0.79842 NaN NaN 1.0646 NaN NaN SNARE endoplasmic reticulum;integral to membrane;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intrinsic to membrane;membrane-bounded organelle;non-membrane-bounded organelle;nucleolus;organelle binding;protein binding;SNAP receptor activity cellular process;establishment of localization;establishment of localization in cell;establishment of protein localization;intracellular protein transport;intracellular transport;protein transport;transport;vesicle-mediated transport SNARE interactions in vesicular transport 3 3 3 13.9 13.9 13.9 33.403 9.4429E-92 4351000 2444100 1906900 989 IPI:IPI00012028.2 Syntaxin-17 STX17 P56962 ENST00000259400 K08491 1 NaN 1.6142 0.76502 NaN 1.0043 0.98004 NDK cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;deoxyribonuclease activity;DNA binding;magnesium ion binding;nuclease activity;nucleic acid binding;nucleoside binding;nucleoside diphosphate kinase activity;nucleotide binding;protein binding;purine nucleoside binding GTP biosynthetic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;pyrimidine nucleoside metabolic process;pyrimidine nucleotide metabolic process Purine metabolism;Pyrimidine metabolism 11 1 1 60.5 7.9 7.9 19.653 1.9753E-181 1884000000 993780000 890200000 990 IPI:IPI00375531.2;IPI:IPI00012048.1 Nucleoside diphosphate kinase A;Tumor metastatic process-associated protein;Metastasis inhibition factor nm23;nm23-H1;Granzyme A-activated DNase NME1;NDPKA;NM23 P15531-2;P15531;P15531-1 ENST00000013034;ENST00000311032;ENST00000336097;ENST00000393196;ENST00000393198 K00940 2 0.81976 1.5822 0.81546 1.0549 1.0487 1.0489 RRM_1 cell part;heterogeneous nuclear ribonucleoprotein complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 29 29 22 44.9 44.9 36.8 70.942 3.0308E-270 7780100000 4101200000 3678800000 991 IPI:IPI00012074.3;IPI:IPI00644055.3 Heterogeneous nuclear ribonucleoprotein R HNRNPR;HNRPR O43390-1;O43390;O43390-2 ENST00000302271;ENST00000374612;ENST00000374616 2 0.79139 1.3645 0.74072 1.0024 0.92369 0.97623 RRM_1 cell part;cytoplasmic part;cytosol;eukaryotic translation initiation factor 4F complex;intracellular part;macromolecular complex;protein complex binding;nucleic acid binding;nucleotide binding;RNA binding;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;regulation of biosynthetic process;regulation of gene expression;regulation of translation;regulation of translational initiation;translation mTOR signaling pathway 8 8 8 17.5 17.5 17.5 69.725 3.4882E-67 1437000000 756050000 680960000 992 IPI:IPI00012079.7 Eukaryotic translation initiation factor 4B EIF4B P23588 ENST00000262056 K03258 1 0.89503 2.0932 1.0278 1.1786 1.3668 1.2793 Sulfatase cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;lysosome;lytic vacuole;membrane-bounded organelle;organelle;vacuole binding;calcium ion binding;catalytic activity;cation binding;hydrolase activity;hydrolase activity, acting on ester bonds;ion binding;metal ion binding;N-acetylglucosamine-6-sulfatase activity;protein binding;sulfuric ester hydrolase activity aminoglycan catabolic process;aminoglycan metabolic process;carbohydrate metabolic process;glycosaminoglycan catabolic process;metabolic process;nitrogen compound metabolic process;polysaccharide catabolic process;polysaccharide metabolic process Glycosaminoglycan degradation 10 10 10 22.3 22.3 22.3 62.081 3.3997E-81 130590000 68282000 62312000 994 IPI:IPI00012102.1 N-acetylglucosamine-6-sulfatase GNS P15586 ENST00000258145 K01137 1 0.62891 1.329 0.6582 0.88147 0.88072 0.86716 Mpp10 intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nucleolus;organelle;organelle part;ribonucleoprotein complex;small nucleolar ribonucleoprotein complex binding;catalytic activity;protein binding;RNA splicing factor activity, transesterification mechanism cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing;rRNA metabolic process;rRNA processing 7 7 7 13.2 13.2 13.2 78.863 3.1161E-73 73991000 40051000 33940000 995 IPI:IPI00012149.1 U3 small nucleolar ribonucleoprotein protein MPP10;M phase phosphoprotein 10 MPHOSPH10;MPP10 O00566 ENST00000244230 1 0.45595 1.076 0.47367 0.59248 0.73507 0.65174 MazG cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;identical protein binding;protein binding;pyrophosphatase activity 3 3 3 22.9 22.9 22.9 18.681 8.036E-18 190300000 104250000 86049000 996 IPI:IPI00012197.1 dCTP pyrophosphatase 1;Deoxycytidine-triphosphatase 1;XTP3-transactivated gene A protein;RS21C6 DCTPP1;XTP3TPA;CDA03 Q9H773 ENST00000319285 1 1.0021 1.7861 NaN 1.2981 1.1751 NaN DUF2452 4 4 4 29.1 29.1 29.1 21.876 1.9641E-10 11250000 6073800 5176000 997 IPI:IPI00012198.4 Uncharacterized protein C1orf50 C1orf50 Q9BV19 ENST00000372525 1 0.64913 1.3925 0.67049 0.90387 0.84728 0.94863 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle interspecies interaction between organisms;multi-organism process 11 11 11 38.6 38.6 38.6 40.235 9.1354E-158 461390000 244860000 216520000 998 IPI:IPI00012199.1 Coiled-coil domain-containing protein 86;Cytokine-induced protein with coiled-coil domain CCDC86;CYCLON Q9H6F5 ENST00000227520 1 0.7335 1.3623 0.73702 0.93976 0.95941 0.91327 WD40 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle cellular component biogenesis;cellular process;ribonucleoprotein complex biogenesis;spliceosomal snRNP biogenesis 8 8 8 33.3 33.3 33.3 36.724 4.6386E-210 468810000 244710000 224100000 999 IPI:IPI00012202.1 Methylosome protein 50;WD repeat-containing protein 77;Androgen receptor cofactor p44;p44/Mep50 WDR77;MEP50;HKMT1069;Nbla10071 Q9BQA1 ENST00000235090 1 0.76463 1.4699 0.75344 1.0024 0.97292 0.98721 PC_rep cell part;cytoplasmic part;cytosol;intracellular part;macromolecular complex;proteasome regulatory particle;protein complex binding;enzyme regulator activity;protein binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;proteasomal protein catabolic process;proteolysis;regulation of catabolic process;regulation of metabolic process;ubiquitin-dependent protein catabolic process Proteasome 44 44 43 56.4 56.4 56.4 100.2 0 4385200000 2334400000 2050800000 1001 IPI:IPI00012268.3 26S proteasome non-ATPase regulatory subunit 2;26S proteasome regulatory subunit RPN1;26S proteasome regulatory subunit S2;26S proteasome subunit p97;Tumor necrosis factor type 1 receptor-associated protein 2;55.11 protein PSMD2;TRAP2 Q13200 ENST00000310118 K03028 1 0.93548 1.6414 0.96415 1.1857 1.0853 1.2314 RRM_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;nucleotide binding;RNA binding anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;mRNA splice site selection;ribonucleoprotein complex assembly 14 13 13 58.4 55.2 55.2 25.542 1.304E-82 1341600000 676690000 664880000 1004 IPI:IPI00012340.1 Splicing factor, arginine/serine-rich 9;Pre-mRNA-splicing factor SRp30C SFRS9;SRP30C Q13242 ENST00000229390 1 0.90287 1.6847 0.93325 1.1711 1.1536 1.2525 RRM_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;nucleotide binding;RNA binding anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;mRNA splice site selection;ribonucleoprotein complex assembly 5 4 4 21 17.6 17.6 31.263 5.484E-78 636450000 316130000 320320000 1005 IPI:IPI00012341.1;IPI:IPI00413654.3;IPI:IPI00221286.1 Splicing factor, arginine/serine-rich 5;Pre-mRNA-splicing factor SRP40;Delayed-early protein HRS SFRS5;HRS;SRP40 Q13243-1;Q13243;Q13243-3 ENST00000394366 3 0.84654 1.4822 0.87597 1.0497 0.99926 1.0774 RRM_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;mRNA splice site selection;ribonucleoprotein complex assembly 10 10 8 20.1 20.1 17.4 39.586 1.3522E-43 4010500000 2367300000 1643200000 1006 IPI:IPI00012345.2;IPI:IPI00215879.1;IPI:IPI00018203.1 Splicing factor, arginine/serine-rich 6;Pre-mRNA-splicing factor SRP55 SFRS6;SRP55 Q13247-1;Q13247;Q13247-3 ENST00000244020;ENST00000328748 3 0.6674 1.339 0.67917 0.90175 0.86882 0.87441 Ribosomal_L3 binding;nucleic acid binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 9 9 9 30.2 30.2 30.2 38.632 2.9645E-41 153510000 84795000 68718000 1007 IPI:IPI00012353.1 39S ribosomal protein L3, mitochondrial MRPL3;MRL3;RPML3 P09001 ENST00000264995 1 0.73137 1.1469 0.71203 0.93193 0.81707 0.87848 HORMA cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle;perinuclear region of cytoplasm binding;identical protein binding;protein binding;protein dimerization activity;protein homodimerization activity catabolic process;cell cycle checkpoint;metabolic process;mitosis;mitotic cell cycle checkpoint;nuclear division;organelle organization;proteolysis;regulation of mitotic cell cycle;ubiquitin-dependent protein catabolic process Cell cycle;Cell cycle - yeast;Progesterone-mediated oocyte maturation 8 8 8 39.5 39.5 39.5 23.51 2.3801E-37 197140000 104260000 92880000 1008 IPI:IPI00012369.1 Mitotic spindle assembly checkpoint protein MAD2A;MAD2-like 1 MAD2L1;MAD2 Q13257 ENST00000296509 K02537 1 0.75041 1.5846 0.76129 1.0173 1.0184 1.0298 RRM_1 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 7 7 5 26.6 26.6 24.1 31.279 2.0221E-46 2025700000 1068700000 957050000 1009 IPI:IPI00012382.3 U1 small nuclear ribonucleoprotein A SNRPA P09012 ENST00000243563 K11091 1 NaN 1.2372 NaN NaN 0.78375 NaN APC_15aa;APC_basic;APC_crr;Arm;EB1_binding;SAMP Axin-APC-beta-catenin-GSK3B complex;beta-catenin destruction complex;centrosome;cytosol;kinetochore;lateral plasma membrane;macromolecular complex;membrane-bounded organelle;microtubule organizing center;non-membrane-bounded organelle;nucleus;organelle beta-catenin binding;binding;cytoskeletal protein binding;enzyme binding;enzyme regulator activity;kinase binding;kinase regulator activity;microtubule binding;protein binding;protein kinase binding;protein kinase regulator activity;tubulin binding cell cycle checkpoint;cytokinesis;cytokinesis after mitosis;negative regulation of protein kinase activity;protein complex assembly;regulation of cyclin-dependent protein kinase activity;response to DNA damage stimulus;response to stress Basal cell carcinoma;Colorectal cancer;Endometrial cancer;Pathways in cancer;Regulation of actin cytoskeleton;Wnt signaling pathway 3 3 3 1.4 1.4 1.4 311.64 0.00033914 1607200 970410 636770 1010 IPI:IPI00012391.3;IPI:IPI00215877.2 Adenomatous polyposis coli protein;Deleted in polyposis 2.5 APC;DP2.5 P25054-1;P25054;P25054-2 ENST00000257430 K02085 2 NaN 1.2685 NaN NaN 0.81816 NaN zf-C2H2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transition metal ion binding;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 2 2 2 11 11 11 31.029 4.4107E-19 675090 305210 369870 1011 IPI:IPI00012411.2 Zinc finger protein 32;Zinc finger protein KOX30;C2H2-546 ZNF32;KOX30 P17041 ENST00000374433;ENST00000395797 1 NaN 1.6559 NaN NaN 1.0526 NaN Peptidase_S10 extracellular region carboxypeptidase activity;catalytic activity;exopeptidase activity;hydrolase activity;peptidase activity;serine hydrolase activity;serine-type carboxypeptidase activity;serine-type exopeptidase activity;serine-type peptidase activity biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis 2 2 2 4.4 4.4 4.4 50.83 1.7745E-13 1073600 617890 455680 1012 IPI:IPI00012426.1;IPI:IPI00477895.3 Retinoid-inducible serine carboxypeptidase;Serine carboxypeptidase 1 SCPEP1;RISC;SCP1;MSTP034;UNQ265/PRO302 Q9HB40-1;Q9HB40;Q9HB40-2 ENST00000262288;ENST00000393142 K09646 2 0.55464 0.88562 0.51756 0.67222 0.63762 0.63414 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 4 4 4 13.2 13.2 13.2 39.103 1.3988E-18 15977000 9366200 6610300 1014 IPI:IPI00012433.2 Factor VIII intron 22 protein;CpG island protein F8A1;F8A;F8A2;F8A3 P23610 ENST00000369445;ENST00000369446;ENST00000369505 1 0.80332 2.1222 0.42442 1.0106 1.291 0.55938 DUF1866;Exo_endo_phos;Syja_N cell part;cytoplasm;intracellular part binding;catalytic activity;hydrolase activity;inositol or phosphatidylinositol phosphatase activity;inositol-polyphosphate 5-phosphatase activity;nucleic acid binding;phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;RNA binding cellular component organization;cellular process;dephosphorylation;endocytosis;membrane invagination;membrane organization;metabolic process;phosphate metabolic process;phosphorus metabolic process;transport;vesicle-mediated transport Inositol phosphate metabolism;Phosphatidylinositol signaling system 3 3 3 2.4 2.4 2.4 173.1 1.0194E-09 3918500 2001600 1916900 1017 IPI:IPI00012441.4;IPI:IPI00658095.4;IPI:IPI00333134.5;IPI:IPI00386631.5 Synaptojanin-1;Synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 SYNJ1;KIAA0910 O43426-1;O43426;O43426-5;O43426-2;O43426-4 ENST00000322229;ENST00000382491;ENST00000382506;ENST00000382509 K01099 4 0.72091 1.425 0.7471 0.95521 0.90994 0.95208 NTF2;RRM_1 cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;nucleus;organelle;plasma membrane ATP-dependent DNA helicase activity;ATP-dependent RNA helicase activity;catalytic activity;DNA binding;DNA helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;RNA binding;RNA helicase activity cell communication;cellular process;intracellular signaling cascade;Ras protein signal transduction;regulation of biological process;regulation of cellular process;signal transduction;small GTPase mediated signal transduction;transport 18 18 16 44 44 41.2 52.164 0 1854400000 949070000 905300000 1018 IPI:IPI00012442.1 Ras GTPase-activating protein-binding protein 1;G3BP-1;ATP-dependent DNA helicase VIII;HDH-VIII;GAP SH3 domain-binding protein 1 G3BP1;G3BP Q13283 ENST00000356245;ENST00000394123 1 0.7414 1.1261 0.66166 0.92747 0.7725 0.80852 FIBP cell fraction;cell part;cytoplasmic part;endomembrane system;insoluble fraction;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane fraction;membrane-bounded organelle;mitochondrion;nucleus;organelle binding;fibroblast growth factor binding;growth factor binding;protein binding cell communication;cell surface receptor linked signal transduction;enzyme linked receptor protein signaling pathway;fibroblast growth factor receptor signaling pathway;signal transduction;transmembrane receptor protein tyrosine kinase signaling pathway 6 6 6 20.1 20.1 20.1 41.878 3.7096E-33 110700000 59636000 51060000 1019 IPI:IPI00012443.1;IPI:IPI00219570.1 Acidic fibroblast growth factor intracellular-binding protein;FGF-1 intracellular-binding protein FIBP O43427-1;O43427;O43427-2 ENST00000338369;ENST00000357519 2 0.7205 1.5589 0.73629 1.0127 1.0018 0.99066 TatD_DNase cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle catalytic activity;deoxyribonuclease activity;endodeoxyribonuclease activity;endodeoxyribonuclease activity, producing 5'-phosphomonoesters;endonuclease activity;hydrolase activity;hydrolase activity, acting on ester bonds;nuclease activity 4 4 4 15.2 15.2 15.2 33.601 5.091E-45 80887000 42403000 38485000 1021 IPI:IPI00012463.4;IPI:IPI00792405.1 Putative deoxyribonuclease TATDN1;Hepatocarcinoma high expression protein TATDN1;CDA11 Q6P1N9-1;Q6P1N9;Q6P1N9-2 ENST00000276692 K03424 2 0.83118 1.758 0.83292 1.1241 1.0509 1.0835 Cation_ATPase_C;Cation_ATPase_N;E1-E2_ATPase;Hydrolase cell part;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part ATP binding;binding;calcium ion binding;calcium-transporting ATPase activity;calmodulin binding;catalytic activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;transporter activity ATP biosynthetic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;transport 14 14 10 15 15 11 137.92 2.2137E-258 214590000 116750000 97831000 1022 IPI:IPI00012490.1;IPI:IPI00217171.1;IPI:IPI00217169.1;IPI:IPI00217170.1;IPI:IPI00217164.1;IPI:IPI00217165.1;IPI:IPI00217166.1;IPI:IPI00217168.1;IPI:IPI00003831.4;IPI:IPI00219258.2;IPI:IPI00219256.2;IPI:IPI00219259.2;IPI:IPI00219257.2;IPI:IPI00219260.2;IPI:IPI00219261.2;IPI:IPI00219262.2;IPI:IPI00219293.1;IPI:IPI00219294.1;IPI:IPI00219295.1 Plasma membrane calcium-transporting ATPase 4;Plasma membrane calcium ATPase isoform 4;Plasma membrane calcium pump isoform 4;Matrix-remodeling-associated protein 1 ATP2B4;ATP2B2;MXRA1 P23634-1;P23634;P23634-8;P23634-6;P23634-7;P23634-2;P23634-3;P23634-4;P23634-5 ENST00000357681;ENST00000367218;ENST00000367219;ENST00000391954 19 0.74168 1.3409 0.74234 1.0086 0.90589 0.95962 Ribosomal_S10 cell part;cytoplasmic part;cytosolic part;cytosolic small ribosomal subunit;intracellular organelle part;intracellular part;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit binding;nucleic acid binding;protein binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 7 7 7 38.7 38.7 38.7 13.373 1.5658E-83 3940300000 2090800000 1849500000 1023 IPI:IPI00012493.1 40S ribosomal protein S20 RPS20 P60866 ENST00000009589 K02969 1 0.40672 0.61605 0.38636 0.50189 0.42482 0.48233 PH;Pkinase;RGS cell fraction;cell part;cytoplasm;intracellular part;membrane;soluble fraction ATP binding;binding;catalytic activity;G-protein coupled receptor kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;signal transducer activity desensitization of G-protein coupled receptor protein signaling pathway;muscle system process;regulation of the force of heart contraction;regulation of the force of heart contraction by chemical signal;system process Chemokine signaling pathway 13 13 8 20.6 20.6 13.5 79.573 3.5686E-52 195230000 110020000 85212000 1024 IPI:IPI00012497.2 Beta-adrenergic receptor kinase 1;G-protein coupled receptor kinase 2 ADRBK1;BARK;BARK1;GRK2 P25098 ENST00000308595 K00910 1 0.86504 1.8906 0.94212 1.1746 1.2077 1.2612 SapA;SapB_1;SapB_2 extracellular region part;extracellular space;Golgi apparatus;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intrinsic to membrane;lysosome;lytic vacuole;membrane-bounded organelle;organelle;vacuole binding;enzyme activator activity;enzyme regulator activity;lipid binding glycolipid metabolic process;glycosphingolipid metabolic process;lipid metabolic process;lipid transport;lysosome organization;membrane lipid metabolic process;organelle organization;sphingolipid metabolic process;transport;vacuole organization 13 13 13 20.5 20.5 20.5 58.483 2.4058E-98 1366900000 700610000 666330000 1025 IPI:IPI00744835.1;IPI:IPI00873201.1;IPI:IPI00012503.1 Proactivator polypeptide;Saposin-A;Protein A;Saposin-B-Val;Saposin-B;Sphingolipid activator protein 1;Cerebroside sulfate activator;Dispersin;Sulfatide/GM1 activator;Saposin-C;Co-beta-glucosidase;A1 activator;Glucosylceramidase activator;Sphingolipid activator protein 2;Saposin-D;Protein C;Component C PSAP;GLBA;SAP1 P07602-3;P07602;P07602-2;P07602-1 ENST00000357471;ENST00000373120;ENST00000394934;ENST00000394936;ENST00000402059;ENST00000404083 K12382 3 0.7645 NaN 0.68557 1.1326 NaN 0.93001 Ras cell part;cytoplasmic part;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;organelle;plasma membrane binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity MAPK signaling pathway;Regulation of actin cytoskeleton;Tight junction 4 4 4 24.8 24.8 24.8 24.195 3.9831E-16 44572000 23357000 21216000 1026 IPI:IPI00012512.2;IPI:IPI00020418.1 Ras-related protein R-Ras2;Ras-like protein TC21;Teratocarcinoma oncogene RRAS2;TC21 P62070 ENST00000256196 K07830 2 NaN 5.3452 2.941 NaN 3.7888 3.7572 NAP cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;chromatin organization;nucleosome assembly;organelle organization 2 2 2 3.7 3.7 3.7 50.55 7.0507E-23 1775700 1118300 657430 1027 IPI:IPI00012528.3 Testis-specific Y-encoded-like protein 4 TSPYL4;KIAA0721 Q9UJ04 ENST00000368611 K11287 1 1.5122 3.0491 1.5333 1.9642 1.9867 2.0154 DnaJ;DnaJ_C;DnaJ_CXXCXGXG cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane;non-membrane-bounded organelle;organelle binding;cation binding;heat shock protein binding;ion binding;lipoprotein receptor binding;low-density lipoprotein receptor binding;metal ion binding;protein binding;receptor binding;transition metal ion binding;unfolded protein binding;zinc ion binding cellular biopolymer metabolic process;cellular process;metabolic process;protein folding;protein metabolic process;response to biotic stimulus;response to chemical stimulus;response to organic substance;response to stress;response to unfolded protein 17 16 16 53.7 53.7 53.7 44.868 6.4897E-300 2663200000 1237900000 1425300000 1028 IPI:IPI00012535.1 DnaJ homolog subfamily A member 1;Heat shock 40 kDa protein 4;DnaJ protein homolog 2;HDJ-2;HSJ-2;HSDJ DNAJA1;DNAJ2;HDJ2;HSJ2;HSPF4 P31689 ENST00000330899 K09502 1 0.72779 1.5438 0.8176 0.98834 0.96195 1.0943 Arm;IBB cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;organelle part;pore complex;protein complex binding;protein binding establishment of protein localization;intracellular protein transport;intracellular transport;NLS-bearing substrate import into nucleus;nucleocytoplasmic transport;protein import;protein import into nucleus;protein targeting;protein transport;transport 12 12 8 27.3 27.3 19.6 57.886 1.1325E-157 292970000 157430000 135530000 1029 IPI:IPI00012578.1 Importin subunit alpha-4;Karyopherin subunit alpha-4;Importin alpha Q1 KPNA4;QIP1 O00629 ENST00000334256 1 0.82986 1.9505 0.87084 1.1367 1.3134 1.1553 Glyco_hydro_20;Glyco_hydro_20b cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;lysosome;lytic vacuole;membrane-bounded organelle;organelle;vacuole beta-N-acetylhexosaminidase activity;binding;catalytic activity;hexosaminidase activity;hydrolase activity;hydrolase activity, acting on glycosyl bonds;hydrolase activity, hydrolyzing O-glycosyl compounds;identical protein binding;protein binding Aminosugars metabolism;Glycosaminoglycan degradation;Glycosphingolipid biosynthesis - ganglio series;Glycosphingolipid biosynthesis - globo series;Other glycan degradation 13 13 13 26.8 26.8 26.8 63.111 5.3322E-74 300610000 163640000 136970000 1030 IPI:IPI00012585.1 Beta-hexosaminidase subunit beta;N-acetyl-beta-glucosaminidase subunit beta;Beta-N-acetylhexosaminidase subunit beta;Cervical cancer proto-oncogene 7 protein;Beta-hexosaminidase subunit beta chain B;Beta-hexosaminidase subunit beta chain A HEXB;HCC7 P07686 ENST00000261416 K12373 1 0.63874 1.0549 0.55099 0.80392 0.753 0.67924 CH;PH;Spectrin cell cortex part;cell part;cytoplasmic part;cytoskeletal part;intracellular organelle part;intracellular part;organelle part;spectrin actin binding;binding;cytoskeletal protein binding;protein binding;structural constituent of cytoskeleton;structural molecule activity cell death;cellular process;negative regulation of macromolecule metabolic process;negative regulation of metabolic process;negative regulation of organelle organization;regulation of actin polymerization or depolymerization;transport 9 2 2 4.1 0.7 0.7 271.29 1.1101E-61 15986000 8777600 7208400 1031 IPI:IPI00012645.1;IPI:IPI00218207.1 Spectrin beta chain, brain 2;Spectrin, non-erythroid beta chain 2;Beta-III spectrin SPTBN2;KIAA0302 O15020-1;O15020;O15020-2 ENST00000309996 K06115 2 NaN 1.1301 0.63133 NaN 0.78506 0.79812 cell part;intracellular binding;protein binding mRNA catabolic process;nuclear-transcribed mRNA catabolic process;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA catabolic process 2 2 2 7.5 7.5 7.5 57.65 1.0101E-28 3738100 2021200 1716900 1032 IPI:IPI00012669.2;IPI:IPI00847553.1 Protein SMG9;Protein smg-9 homolog SMG9;C19orf61 Q9H0W8-1;Q9H0W8;Q9H0W8-2 ENST00000222379;ENST00000270066 2 0.2366 NaN NaN 0.31422 NaN NaN HLH cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding;transcription regulator activity;transcription repressor activity angiogenesis;cell motion;cellular process;negative regulation of biosynthetic process;negative regulation of metabolic process;protein localization;regulation of biosynthetic process;regulation of gene expression;regulation of transcription, DNA-dependent TGF-beta signaling pathway 2 2 2 18.7 18.7 18.7 16.132 3.6237E-24 1910100 1367400 542760 1033 IPI:IPI00012718.2;IPI:IPI00218515.1 DNA-binding protein inhibitor ID-1;Inhibitor of DNA binding 1 ID1;ID P41134-1;P41134;P41134-2 ENST00000376105;ENST00000376112 K04680 2 0.73938 1.4177 0.65523 0.95308 0.91687 0.93111 PABP;RRM_1 cell part;cytoplasm;intracellular part binding;mRNA binding;nucleic acid binding;nucleotide binding;poly(A) RNA binding;poly(U) RNA binding;poly-purine tract binding;poly-pyrimidine tract binding;protein binding;RNA binding;single-stranded RNA binding blood coagulation;catabolic process;hemostasis;macromolecule catabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA catabolic process;RNA processing;translation 23 12 11 34.5 18 16.6 70.782 0 1319800000 715070000 604720000 1034 IPI:IPI00012726.4;IPI:IPI00555747.1 Polyadenylate-binding protein 4;Inducible poly(A)-binding protein;Activated-platelet protein 1 PABPC4;APP1;PABP4 Q13310-1;Q13310;Q13310-2 ENST00000372856;ENST00000372857;ENST00000372858 2 0.76025 1.4383 0.76996 0.97766 0.96142 1.0342 AMP-binding cell fraction;cytosol;endoplasmic reticulum membrane;insoluble fraction;integral to membrane;intrinsic to membrane;membrane;membrane fraction;microbody membrane;microsome;mitochondrial outer membrane;organelle membrane;outer membrane;peroxisomal membrane ATP binding;binding;catalytic activity;fatty-acid ligase activity;ligase activity;ligase activity, forming carbon-sulfur bonds;long-chain-fatty-acid-CoA ligase activity;magnesium ion binding;nucleoside binding;nucleotide binding;purine nucleoside binding cellular process;digestion;fatty acid metabolic process;lipid metabolic process;metabolic process;organic acid metabolic process;regulation of cellular ketone metabolic process;regulation of lipid metabolic process Adipocytokine signaling pathway;Fatty acid metabolism;PPAR signaling pathway 14 14 13 20.5 20.5 18.9 77.942 1.2415E-45 163800000 84839000 78958000 1035 IPI:IPI00012728.1;IPI:IPI00401448.1;IPI:IPI00657883.3;IPI:IPI00658107.3;IPI:IPI00879209.3;IPI:IPI00296333.6;IPI:IPI00939479.1;IPI:IPI00940097.1;IPI:IPI00657816.3;IPI:IPI00384110.2 Long-chain-fatty-acid--CoA ligase 1;Long-chain acyl-CoA synthetase 1;Long-chain acyl-CoA synthetase 2;Palmitoyl-CoA ligase 1;Palmitoyl-CoA ligase 2;Acyl-CoA synthetase 1;Long-chain fatty acid-CoA ligase 2 ACSL1;FACL1;FACL2;LACS;LACS1;LACS2 P33121-1;P33121;P33121-2 ENST00000281455 K01897 10 0.65252 1.3481 0.68765 0.86895 0.90877 0.8898 Ribosomal_S25 cytosolic small ribosomal subunit;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nucleolus;organelle;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit binding;nucleic acid binding;protein binding;RNA binding biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 8 8 8 37.6 37.6 37.6 13.742 1.9807E-36 4407800000 2391000000 2016800000 1036 IPI:IPI00012750.3 40S ribosomal protein S25 RPS25 P62851 ENST00000236900 K02975 1 0.66351 1.8974 0.90608 0.94777 1.2021 1.1813 TPR_1 binding 3 3 3 7.5 7.5 7.5 55.846 2.5599E-20 4115900 2154800 1961100 1037 IPI:IPI00012756.1 Interferon-induced protein with tetratricopeptide repeats 5;Retinoic acid- and interferon-inducible 58 kDa protein IFIT5;RI58 Q13325 ENST00000371795 1 0.73796 1.3465 0.70848 0.99526 0.89511 0.92879 Ribosomal_L2;Ribosomal_L2_C cell part;cytoplasmic part;cytosolic large ribosomal subunit;cytosolic part;intracellular organelle part;intracellular part;large ribosomal subunit;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit binding;nucleic acid binding;RNA binding;rRNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 16 16 16 58.4 58.4 58.4 28.024 1.7068E-256 4896100000 2591100000 2305000000 1038 IPI:IPI00012772.8 60S ribosomal protein L8 RPL8 P62917 ENST00000262584;ENST00000394920 K02938 1 0.67358 1.3095 0.65831 0.87451 0.86288 0.89969 BAH;ELM2;GATA;Myb_DNA-binding cell part;cytoplasm;intracellular part binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;sequence-specific DNA binding;transcription factor activity;transcription regulator activity;transition metal ion binding;zinc ion binding cell communication;cellular process;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of transcription, DNA-dependent;signal transduction 17 15 13 30.8 27.6 23.6 80.785 1.0906E-203 356730000 196400000 160330000 1039 IPI:IPI00012773.2;IPI:IPI00215764.1 Metastasis-associated protein MTA1 MTA1 Q13330-1;Q13330;Q13330-2 ENST00000331320 K11660 2 0.58983 1.1807 0.52253 0.75151 0.86077 0.69945 RNA_polI_A34 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleolar part;nucleoplasm part;organelle part;protein complex;RNA polymerase I transcription factor complex;transcription factor complex binding;catalytic activity;DNA-directed RNA polymerase activity;nucleotidyltransferase activity;protein binding;RNA polymerase activity;transferase activity;transferase activity, transferring phosphorus-containing groups cell communication;cell surface receptor linked signal transduction;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;signal transduction;transcription;transcription, DNA-dependent 4 4 4 13.3 13.3 13.3 55.171 2.5782E-70 83159000 40277000 42882000 1040 IPI:IPI00012788.1;IPI:IPI00645816.1 DNA-directed RNA polymerase I subunit RPA34;RNA polymerase I-associated factor PAF49;Anti-sense to ERCC-1 protein;CD3-epsilon-associated protein;A34.5 CD3EAP;ASE1;CAST;PAF49 O15446-2;O15446;O15446-1 ENST00000309424 2 0.89379 1.4605 0.8847 1.1627 0.97498 1.1502 WD40 cell part;cytoplasmic part;cytosol;eukaryotic translation initiation factor 3 complex;intracellular part;macromolecular complex;protein complex binding;nucleic acid binding;protein binding;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity cellular process;translational initiation 17 17 17 72 72 72 36.501 1.0251E-243 1263600000 638140000 625450000 1041 IPI:IPI00012795.3 Eukaryotic translation initiation factor 3 subunit I;Eukaryotic translation initiation factor 3 subunit 2;eIF-3-beta;eIF3 p36;TGF-beta receptor-interacting protein 1 EIF3I;EIF3S2;TRIP1 Q13347 ENST00000373586 K03246 1 0.70932 1.7448 0.71617 0.91176 1.1771 0.9857 Thiolase_C;Thiolase_N cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;microbody;organelle;peroxisome acetyl-CoA C-acyltransferase activity;acyltransferase activity;binding;C-acyltransferase activity;catalytic activity;protein binding;transferase activity;transferase activity, transferring acyl groups carboxylic acid metabolic process;cellular process;fatty acid metabolic process;generation of precursor metabolites and energy;lipid metabolic process;metabolic process;monocarboxylic acid metabolic process;organic acid metabolic process 11 11 11 35.1 35.1 35.1 44.292 4.8117E-126 130990000 74067000 56927000 1042 IPI:IPI00012828.3 3-ketoacyl-CoA thiolase, peroxisomal;Beta-ketothiolase;Acetyl-CoA acyltransferase;Peroxisomal 3-oxoacyl-CoA thiolase ACAA1;ACAA;PTHIO P09110 ENST00000333167 1 0.73824 1.4971 0.94547 1.0743 0.99169 1.23 Metallophos centrosome;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;microtubule organizing center;non-membrane-bounded organelle;nucleus;organelle;organelle part catalytic activity;NF-kappaB-inducing kinase activity;phosphoprotein phosphatase activity;protein kinase activity;protein serine/threonine kinase activity;receptor signaling protein serine/threonine kinase activity cellular component organization;cellular process;cytoskeleton organization;microtubule cytoskeleton organization;microtubule-based process;organelle organization 11 9 9 45 40.1 40.1 35.08 2.7765E-151 190290000 102550000 87740000 1044 IPI:IPI00012833.1 Serine/threonine-protein phosphatase 4 catalytic subunit;Protein phosphatase X PPP4C;PPP4;PPX P60510 ENST00000279387 K01090 1 0.95772 1.8191 0.82447 1.1824 1.2543 1.0236 B56 intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;protein complex;protein phosphatase type 2A complex;protein serine/threonine phosphatase complex binding;enzyme regulator activity;phosphatase regulator activity;protein binding;protein phosphatase regulator activity;protein phosphatase type 2A regulator activity catabolic process;cell communication;cellular process;macromolecule catabolic process;metabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;signal transduction;ubiquitin-dependent protein catabolic process Wnt signaling pathway 14 7 7 28.6 16.8 16.8 61.06 1.1207E-183 158850000 109090000 49764000 1045 IPI:IPI00012834.4;IPI:IPI00220145.4;IPI:IPI00185637.2 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform;PP2A, B subunit, B' gamma isoform;PP2A, B subunit, B56 gamma isoform;PP2A, B subunit, PR61 gamma isoform;PP2A, B subunit, R5 gamma isoform;Renal carcinoma antigen NY-REN-29 PPP2R5C;KIAA0044 Q13362-1;Q13362;Q13362-3;Q13362-2 ENST00000328724;ENST00000334743;ENST00000350249 K11584 3 0.83455 1.6679 0.84633 1.0531 1.1506 1.0391 2-Hacid_dh;2-Hacid_dh_C cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;protein binding;protein C-terminus binding;transcription factor binding cellular process;metabolic process;negative regulation of cell proliferation;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein modification process;viral genome replication 11 11 7 28.6 28.6 18.4 47.535 3.0764E-127 390310000 206150000 184170000 1046 IPI:IPI00012835.1;IPI:IPI00010120.4 C-terminal-binding protein 1 CTBP1;CTBP Q13363 ENST00000290921 2 0.77812 1.5325 0.75028 1.027 0.99733 0.99783 Kinesin cell part;cytoplasmic part;cytoskeletal part;intracellular organelle part;intracellular part;kinesin complex;macromolecular complex;microtubule;microtubule associated complex;organelle part;perinuclear region of cytoplasm;protein complex ATP binding;binding;catalytic activity;cytoskeletal protein binding;microtubule binding;microtubule motor activity;motor activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity;tubulin binding cellular process;cytoskeleton-dependent intracellular transport;establishment of localization;intracellular transport;microtubule-based movement;microtubule-based process;microtubule-based transport;transport;vesicle transport along microtubule 29 29 24 34 34 28 109.68 0 961930000 519700000 442230000 1047 IPI:IPI00012837.1;IPI:IPI00028561.1;IPI:IPI00889664.2 Kinesin-1 heavy chain;Ubiquitous kinesin heavy chain;Conventional kinesin heavy chain KIF5B;KNS;KNS1 P33176 ENST00000302418;ENST00000403329 K10396 3 0.27905 0.66701 0.14052 0.38889 0.43752 0.18779 PH;Pkinase;Pkinase_C cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;membrane;nuclear part;nucleoplasm;organelle part;plasma membrane binding;catalytic activity;cation:sugar symporter activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;sugar:hydrogen symporter activity;transporter activity carbohydrate metabolic process;glycogen metabolic process;polysaccharide biosynthetic process;polysaccharide metabolic process;protein import into nucleus, translocation;regulation of cell growth;regulation of cyclin-dependent protein kinase activity Acute myeloid leukemia;Adipocytokine signaling pathway;Apoptosis;B cell receptor signaling pathway;Chemokine signaling pathway;Chronic myeloid leukemia;Colorectal cancer;Endometrial cancer;ErbB signaling pathway;Fc epsilon RI signaling pathway;Focal adhesion;Glioma;Insulin signaling pathway;Jak-STAT signaling pathway;MAPK signaling pathway;Melanoma;mTOR signaling pathway;Non-small cell lung cancer;Pancreatic cancer;Pathways in cancer;Progesterone-mediated oocyte maturation;Prostate cancer;Renal cell carcinoma;Small cell lung cancer;T cell receptor signaling pathway;Tight junction;Toll-like receptor signaling pathway;VEGF signaling pathway 6 4 4 15.4 11.7 11.7 55.686 3.6804E-25 21569000 12708000 8861000 1049 IPI:IPI00012866.2 RAC-alpha serine/threonine-protein kinase;RAC-PK-alpha;Protein kinase B;C-AKT AKT1;PKB;RAC P31749 ENST00000349310;ENST00000402615;ENST00000407796 K04456 1 0.53564 0.99208 0.62965 0.72988 0.60991 0.83426 PH;Pkinase;Pkinase_C cell part;cytoplasmic part;cytosol;intracellular part ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cell communication;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;regulation of carbohydrate metabolic process;regulation of glycogen biosynthetic process;signal transduction Acute myeloid leukemia;Adipocytokine signaling pathway;Apoptosis;B cell receptor signaling pathway;Chemokine signaling pathway;Chronic myeloid leukemia;Colorectal cancer;Endometrial cancer;ErbB signaling pathway;Fc epsilon RI signaling pathway;Focal adhesion;Glioma;Insulin signaling pathway;Jak-STAT signaling pathway;MAPK signaling pathway;Melanoma;mTOR signaling pathway;Non-small cell lung cancer;Pancreatic cancer;Pathways in cancer;Progesterone-mediated oocyte maturation;Prostate cancer;Renal cell carcinoma;Small cell lung cancer;T cell receptor signaling pathway;Tight junction;Toll-like receptor signaling pathway;VEGF signaling pathway 10 10 8 22.5 22.5 18.7 55.768 3.3184E-26 165670000 79913000 85762000 1050 IPI:IPI00012870.1 RAC-beta serine/threonine-protein kinase;RAC-PK-beta;Protein kinase Akt-2;Protein kinase B, beta AKT2 P31751 ENST00000392038 K04456 1 0.52651 NaN 0.49241 0.65796 NaN 0.61601 FERM_M;Focal_AT;Pkinase_Tyr adherens junction;cell junction;cell-substrate adherens junction;cell-substrate junction;cytoskeleton;cytosol;focal adhesion;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle binding;catalytic activity;non-membrane spanning protein tyrosine kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein tyrosine kinase activity;purine nucleoside binding;signal transducer activity cell communication;cell surface receptor linked signal transduction;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein complex assembly;protein modification process;signal transduction Axon guidance;Chemokine signaling pathway;ErbB signaling pathway;Focal adhesion;Leukocyte transendothelial migration;Pathways in cancer;Regulation of actin cytoskeleton;Small cell lung cancer;VEGF signaling pathway 2 2 2 2.8 2.8 2.8 119.23 1.0024E-08 9015100 5155400 3859700 1051 IPI:IPI00012885.1;IPI:IPI00871963.2;IPI:IPI00216217.1;IPI:IPI00216218.1 Focal adhesion kinase 1;pp125FAK;Protein-tyrosine kinase 2 PTK2;FAK;FAK1 Q05397-1;Q05397;Q05397-2;Q05397-3;Q05397-4 ENST00000340930;ENST00000342207;ENST00000354438;ENST00000395223 K05725 4 0.68942 1.1706 0.53713 0.8706 0.83392 0.66879 Pkinase cell part;cytoplasmic part;intracellular part;macromolecular complex;phosphorylase kinase complex;protein complex binding;calmodulin-dependent protein kinase activity;catalytic activity;nucleoside binding;nucleotide binding;phosphorylase kinase activity;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding carbohydrate metabolic process;cellular glucan metabolic process;generation of precursor metabolites and energy;glycogen biosynthetic process;glycogen metabolic process;polysaccharide biosynthetic process;polysaccharide metabolic process Calcium signaling pathway;Insulin signaling pathway 5 5 5 13.1 13.1 13.1 46.442 3.1735E-24 20392000 10199000 10193000 1052 IPI:IPI00012891.1 Phosphorylase b kinase gamma catalytic chain, testis/liver isoform;Phosphorylase kinase subunit gamma 2;PSK-C3 PHKG2 P15735 ENST00000328273 K00871 1 NaN 0.99466 NaN NaN 0.60097 NaN cell part;external side of plasma membrane;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part binding;cytokine binding;cytokine receptor activity;growth factor binding;interleukin-2 binding;molecular transducer activity;protein binding;receptor activity;signal transducer activity;transmembrane receptor activity cell communication;cellular process;immune response;immune system process;interspecies interaction between organisms;multi-organism process;regulation of biological process;regulation of cellular process;response to stimulus;signal transduction Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Primary immunodeficiency 2 2 2 9.2 9.2 9.2 42.287 1.9258E-11 11634000 5828700 5805800 1053 IPI:IPI00012899.1 Cytokine receptor common gamma chain;Interleukin-2 receptor gamma chain;p64 IL2RG P31785 ENST00000276110 K05070 1 0.79633 1.7447 0.78212 1.0375 1.1142 1.0452 Carn_acyltransf cell part;cytoplasmic part;intracellular organelle part;intracellular part;membrane;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part acyltransferase activity;carnitine O-acyltransferase activity;carnitine O-palmitoyltransferase activity;catalytic activity;O-acyltransferase activity;O-palmitoyltransferase activity;palmitoyltransferase activity;transferase activity amino acid transport;carnitine shuttle;cation transport;fatty acid beta-oxidation;fatty acid metabolic process;ion transport;lipid metabolic process;lipid transport;metabolic process;mitochondrial transport;organic acid metabolic process;transport Fatty acid metabolism;PPAR signaling pathway 17 17 17 29.3 29.3 29.3 73.776 6.1552E-74 432820000 233830000 198990000 1055 IPI:IPI00012912.1 Carnitine O-palmitoyltransferase 2, mitochondrial;Carnitine palmitoyltransferase II CPT2;CPT1 P23786 ENST00000371486 K08766 1 0.82234 1.3319 0.76783 1.0461 0.90171 0.986 ITAM external side of plasma membrane;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;macromolecular complex;membrane part;plasma membrane part;protein complex;receptor complex;T cell receptor complex binding;enzyme binding;kinase binding;protein binding;protein kinase binding;receptor activity;receptor binding;receptor signaling protein activity;SH3 domain binding;signal transducer activity;structural molecule activity;transmembrane receptor activity cell activation;cell communication;immune system process;positive regulation of immune system process;positive regulation of leukocyte activation;protein complex assembly;regulation of immune system process;regulation of leukocyte activation Hematopoietic cell lineage;Primary immunodeficiency;T cell receptor signaling pathway 8 8 8 36.7 36.7 36.7 23.147 5.9851E-108 539240000 281230000 258010000 1056 IPI:IPI00012923.1 T-cell surface glycoprotein CD3 epsilon chain;T-cell surface antigen T3/Leu-4 epsilon chain CD3E;T3E P07766 ENST00000361763 K06451 1 0.94635 1.562 0.99783 1.1852 1.0454 1.3324 HLH binding;DNA binding;nucleic acid binding;RNA polymerase II transcription factor activity;transcription regulator activity immune system process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 9 9 9 18.2 18.2 18.2 72.964 4.4075E-55 345690000 174370000 171320000 1057 IPI:IPI00012966.1;IPI:IPI00221261.3;IPI:IPI00013492.1;IPI:IPI00221260.2 Transcription factor 12;Transcription factor HTF-4;E-box-binding protein;DNA-binding protein HTF4 TCF12;HEB;HTF4 Q99081 ENST00000267811;ENST00000333725 K09063 4 0.8164 1.6369 0.86916 1.0892 1.0731 1.1537 Metallophos cell part;cytoplasmic part;cytosol;intracellular part binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;iron ion binding;manganese ion binding;phosphatase activity;phosphoprotein phosphatase activity;protein binding;protein serine/threonine phosphatase activity cellular process;dephosphorylation;G1/S transition of mitotic cell cycle;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid dephosphorylation;protein metabolic process;protein modification process 10 10 10 43.6 43.6 43.6 35.144 1.0085E-160 696140000 369740000 326390000 1058 IPI:IPI00012970.1;IPI:IPI00890827.1 Serine/threonine-protein phosphatase 6 catalytic subunit PPP6C;PPP6 O00743-1;O00743;O00743-2 ENST00000373547 K01090 2 0.57277 1.3354 0.6088 0.7579 0.90285 0.74682 NDK intracellular part;membrane;membrane-enclosed lumen;mitochondrial inner membrane;mitochondrial intermembrane space;mitochondrial membrane;mitochondrial part;organelle envelope lumen;organelle inner membrane;organelle membrane;organelle part ATP binding;binding;catalytic activity;kinase activity;magnesium ion binding;nucleoside binding;nucleoside diphosphate kinase activity;nucleotide binding;purine nucleoside binding;transferase activity GTP biosynthetic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;pyrimidine nucleoside metabolic process;pyrimidine nucleotide metabolic process Purine metabolism;Pyrimidine metabolism 4 4 4 27.8 27.8 27.8 20.658 8.4839E-34 83004000 46004000 37000000 1059 IPI:IPI00012972.3 Nucleoside diphosphate kinase, mitochondrial;nm23-H4;Nucleoside diphosphate kinase D NME4;NM23D O00746 ENST00000219479;ENST00000382940 K00940 1 0.86286 1.5732 0.34982 1.1909 1.0233 0.44397 Alpha-mann_mid;Glyco_hydro_38;Glyco_hydro_38C cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;lysosome;lytic vacuole;membrane-bounded organelle;organelle;vacuole alpha-mannosidase activity;binding;carbohydrate binding;catalytic activity;hydrolase activity;hydrolase activity, acting on glycosyl bonds;hydrolase activity, hydrolyzing O-glycosyl compounds;ion binding;mannosidase activity;zinc ion binding catabolic process;cellular process;glycoprotein catabolic process;glycoprotein metabolic process;macromolecule catabolic process;metabolic process;protein deglycosylation;protein metabolic process;protein modification process Other glycan degradation 4 4 4 4.6 4.6 4.6 113.74 9.5542E-15 6980600 3614600 3366000 1060 IPI:IPI00012989.2 Lysosomal alpha-mannosidase;Lysosomal acid alpha-mannosidase;Mannosidase alpha class 2B member 1;Lysosomal alpha-mannosidase A peptide;Lysosomal alpha-mannosidase B peptide;Lysosomal alpha-mannosidase C peptide;Lysosomal alpha-mannosidase D peptide;Lysosomal alpha-mannosidase E peptide MAN2B1;LAMAN;MANB O00754 ENST00000221363 K12311 1 0.76489 1.4031 0.77231 1.0008 0.94502 0.98287 RRM_1 cell part;intracellular organelle part;intracellular part;macromolecular complex;mRNA cleavage factor complex;nuclear body;nuclear part;nucleoplasm part;organelle part;paraspeckles;protein complex;ribonucleoprotein complex binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding cellular biopolymer metabolic process;cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing 11 11 11 23.8 23.8 23.8 63.47 0 1044900000 549560000 495340000 1061 IPI:IPI00030654.1;IPI:IPI00012998.2;IPI:IPI00647126.2 Cleavage and polyadenylation specificity factor subunit 6;Cleavage and polyadenylation specificity factor 68 kDa subunit;Pre-mRNA cleavage factor Im 68 kDa subunit;Protein HPBRII-4/7 CPSF6;CFIM68 Q16630-2;Q16630;Q16630-1;Q16630-3 ENST00000266679;ENST00000351671 3 1.9428 4.1068 2.069 2.5306 2.8655 2.5505 UQ_con cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part acid-amino acid ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleoside binding;nucleotide binding;purine nucleoside binding;ubiquitin-protein ligase activity cytoskeleton organization;microtubule cytoskeleton organization;microtubule-based process;mitosis;nuclear division;organelle organization;protein modification process;proteolysis;spindle organization;ubiquitin-dependent protein catabolic process Ubiquitin mediated proteolysis 4 4 4 30.2 30.2 30.2 19.652 4.3193E-26 12624000 6273500 6350100 1062 IPI:IPI00013002.1 Ubiquitin-conjugating enzyme E2 C;Ubiquitin-protein ligase C;Ubiquitin carrier protein C;UbcH10 UBE2C;UBCH10 O00762 ENST00000356455 K06688 1 0.56851 1.082 NaN 0.76118 0.69729 NaN C2;HECT;WW cell part;intracellular part;macromolecular complex;protein complex;ubiquitin ligase complex acid-amino acid ligase activity;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;protein binding;small conjugating protein ligase activity;ubiquitin-protein ligase activity catabolic process;cellular process;entry into host cell;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;protein modification process;proteolysis Ubiquitin mediated proteolysis 3 2 2 4.1 3 3 98.911 3.3375E-74 3155100 1743000 1412100 1064 IPI:IPI00013010.6 NEDD4-like E3 ubiquitin-protein ligase WWP2;WW domain-containing protein 2;Atrophin-1-interacting protein 2 WWP2 O00308 ENST00000356003;ENST00000359154 K05630 1 0.7663 1.4338 0.75787 1.0061 0.95103 0.96648 eIF3_N;PCI cell part;cytoplasmic part;cytosol;eukaryotic translation initiation factor 3 complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;protein complex binding;nucleic acid binding;protein binding;protein N-terminus binding;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity mRNA catabolic process;nuclear-transcribed mRNA catabolic process;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA catabolic process;translational initiation 25 25 25 54.6 54.6 54.6 52.22 0 2380900000 1226600000 1154300000 1066 IPI:IPI00013068.1 Eukaryotic translation initiation factor 3 subunit E;Eukaryotic translation initiation factor 3 subunit 6;eIF-3 p48;Viral integration site protein INT-6 homolog EIF3E;EIF3S6;INT6 P60228 ENST00000220849 K03250 1 0.70894 1.4941 0.75606 0.98626 0.99117 1.0103 SAP;SPRY cell part;heterogeneous nuclear ribonucleoprotein complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex binding;nucleic acid binding;protein binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile;transcription 25 24 24 32.1 31.4 31.4 95.737 0 1192300000 622030000 570230000 1067 IPI:IPI00013070.2;IPI:IPI00167147.1;IPI:IPI00736859.1;IPI:IPI00402391.3 Heterogeneous nuclear ribonucleoprotein U-like protein 1;Adenovirus early region 1B-associated protein 5;E1B-55 kDa-associated protein 5 HNRNPUL1;E1BAP5;HNRPUL1 Q9BUJ2-1;Q9BUJ2;Q9BUJ2-2;Q9BUJ2-4;Q9BUJ2-3 ENST00000263367;ENST00000352456;ENST00000378215;ENST00000392006 4 0.64348 1.396 NaN 0.86628 0.9491 NaN AAA;Vps4_C centrosome;cytoplasmic part;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;microtubule;microtubule organizing center;non-membrane-bounded organelle;organelle;organelle part;spindle pole ATP binding;binding;catalytic activity;cytoskeletal protein binding;microtubule binding;microtubule-severing ATPase activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity;tubulin binding cell cycle phase;cell cycle process;cell division;cellular component organization;cellular process;interphase;interphase of mitotic cell cycle;mitosis;nuclear division;organelle fission;organelle organization 4 4 3 8.1 8.1 6.7 55.964 1.0027E-07 19588000 10319000 9269400 1068 IPI:IPI00013075.1;IPI:IPI00384339.5 Katanin p60 ATPase-containing subunit A1;p60 katanin KATNA1 O75449-1;O75449;O75449-2 ENST00000335643;ENST00000335647;ENST00000367411 K07767 2 0.7281 1.9278 NaN 0.99936 1.1019 NaN FOP_dimer centrosome;cytoplasmic part;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;microtubule organizing center;non-membrane-bounded organelle;organelle;organelle part cellular component organization;cellular process;cytoskeleton organization;maintenance of protein location in cell;microtubule cytoskeleton organization;microtubule-based process;organelle organization;positive regulation of cell proliferation 4 4 4 14.3 14.3 14.3 43.064 2.1991E-13 7061400 4066600 2994900 1069 IPI:IPI00013076.1;IPI:IPI00305013.4;IPI:IPI00941898.1 FGFR1 oncogene partner FGFR1OP;FOP O95684-1;O95684;O95684-2 ENST00000349556;ENST00000366847 3 0.8964 2.0339 0.91077 1.1899 1.2735 1.2684 CDC37_C;CDC37_M;CDC37_N binding;protein binding;unfolded protein binding intracellular protein transport;protein targeting;protein transport;regulation of cell communication;regulation of cyclin-dependent protein kinase activity;regulation of cytokine-mediated signaling pathway;regulation of signal transduction;transport 17 17 17 44.7 44.7 44.7 44.468 0 1614400000 840290000 774100000 1070 IPI:IPI00013122.1 Hsp90 co-chaperone Cdc37;Hsp90 chaperone protein kinase-targeting subunit;p50Cdc37 CDC37;CDC37A Q16543 ENST00000222005 K09554 1 0.68658 1.5226 0.7433 0.96044 0.94614 0.95327 MRP-S22 cytoplasmic part;intracellular part;macromolecular complex;mitochondrial part;mitochondrial small ribosomal subunit;organellar small ribosomal subunit;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit binding;protein binding;structural constituent of ribosome;structural molecule activity 10 10 10 33.9 33.9 33.9 41.28 6.5787E-87 236780000 127830000 108960000 1071 IPI:IPI00013146.1 28S ribosomal protein S22, mitochondrial;MRP-S22 MRPS22;C3orf5;RPMS22;GK002 P82650 ENST00000310776 1 0.74541 1.5149 0.85659 0.95522 1.0262 1.096 SUI1 cell part;cytoplasm;intracellular part;membrane binding;molecular transducer activity;nucleic acid binding;protein binding;receptor activity;RNA binding;signal transducer activity;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity cellular process;establishment of localization;establishment of localization in cell;establishment of protein localization;intracellular protein transport;intracellular transport;protein transport;translational initiation;transport 10 10 10 22.1 22.1 22.1 64.706 2.7498E-270 789620000 77486000 712140000 1072 IPI:IPI00013160.2;IPI:IPI00183443.5 Ligatin;Hepatocellular carcinoma-associated antigen 56 LGTN;HCA56 P41214-1;P41214;P41214-2 ENST00000271764;ENST00000367114 2 0.63304 1.5241 1.0181 0.79721 0.9824 1.2779 L51_S25_CI-B8 cytoplasmic part;intracellular part;macromolecular complex;mitochondrial part;mitochondrial small ribosomal subunit;organellar small ribosomal subunit;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit binding;protein binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 6 6 6 47.4 47.4 47.4 20.116 5.3074E-20 26108000 13437000 12671000 1073 IPI:IPI00013167.1 28S ribosomal protein S25, mitochondrial;MRP-S25 MRPS25;RPMS25 P82663 ENST00000253686 1 0.76749 1.2925 0.72035 0.94724 0.89267 0.90392 RRM_1 cell part;intracellular organelle part;intracellular part;macromolecular complex;mediator complex;nuclear part;nucleoplasm part;organelle part;protein complex;ribonucleoprotein complex;transcription factor complex binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding;RNA polymerase II transcription factor activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding chromatin organization;DNA metabolic process;DNA recombination;DNA repair;DNA replication;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 17 17 17 26.6 26.6 26.6 69.491 8.9921E-257 2160000000 1139300000 1020700000 1074 IPI:IPI00013174.2;IPI:IPI00644837.1 RNA-binding protein 14;RNA-binding motif protein 14;RRM-containing coactivator activator/modulator;Synaptotagmin-interacting protein;Paraspeckle protein 2 RBM14;SIP Q96PK6-1;Q96PK6 ENST00000310137 2 1.0041 1.605 1.0262 1.2832 1.101 1.311 G10 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;transcription factor activity;transcription regulator activity;transition metal ion binding;zinc ion binding regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent 8 8 8 34.7 34.7 34.7 17 1.2583E-29 345030000 176570000 168460000 1075 IPI:IPI00013180.2 Protein BUD31 homolog;Protein G10 homolog;EDG-2 BUD31;EDG2 P41223 ENST00000222969;ENST00000403633 1 0.67916 1.4576 0.6623 0.92004 0.93329 0.88652 Acetyltransf_1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle acetyltransferase activity;acyltransferase activity;binding;catalytic activity;N-acetyltransferase activity;N-acyltransferase activity;peptide alpha-N-acetyltransferase activity;protein binding;transferase activity cellular component organization;cellular process;DNA packaging;internal protein amino acid acetylation;metabolic process;N-terminal protein amino acid acetylation;peptidyl-amino acid modification;protein amino acid acetylation;protein modification process 1- and 2-Methylnaphthalene degradation;Benzoate degradation via CoA ligation;Ethylbenzene degradation;Glycerophospholipid metabolism;Limonene and pinene degradation;Phenylalanine metabolism;Tyrosine metabolism 8 8 8 39.1 39.1 39.1 26.458 5.9004E-112 1015900000 565700000 450160000 1076 IPI:IPI00013184.1;IPI:IPI00455623.4 N-terminal acetyltransferase complex ARD1 subunit homolog A ARD1A;ARD1;TE2 P41227 ENST00000370015 K00680 2 0.71397 1.3345 0.62816 0.94762 0.84861 0.78458 Img2 intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;mitochondrion;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 4 4 4 23.5 23.5 23.5 19.198 1.5863E-22 31645000 18933000 12711000 1077 IPI:IPI00013195.1 39S ribosomal protein L49, mitochondrial;L49mt;MRP-L49;Protein NOF1;Neighbor of FAU MRPL49;C11orf4;NOF1;OK/SW-cl.67 Q13405 ENST00000279242 1 0.56955 1.161 0.60328 0.74334 0.76267 0.77172 Pkinase_Tyr;SH2;SH3_1 cell part;cytoplasm;intracellular part ATP binding;binding;catalytic activity;non-membrane spanning protein tyrosine kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein tyrosine kinase activity;purine nucleoside binding cellular biopolymer metabolic process;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process Chemokine signaling pathway;Epithelial cell signaling in Helicobacter pylori infection;Regulation of actin cytoskeleton 27 27 27 61.3 61.3 61.3 50.704 0 1255300000 661920000 593340000 1079 IPI:IPI00013212.1;IPI:IPI00000868.1 Tyrosine-protein kinase CSK;C-SRC kinase;Protein-tyrosine kinase CYL CSK P41240 ENST00000220003 K05728 2 NaN 0.8738 NaN NaN 0.62262 NaN ORC2 cell part;chromosomal part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;origin recognition complex;protein complex binding;DNA binding;DNA replication origin binding;nucleic acid binding;protein binding;sequence-specific DNA binding DNA metabolic process;DNA replication initiation;negative regulation of transcription from RNA polymerase II promoter;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent Cell cycle;Cell cycle - yeast 3 3 3 7.3 7.3 7.3 65.971 2.7882E-36 6381000 2775700 3605300 1080 IPI:IPI00013216.1 Origin recognition complex subunit 2 ORC2L;ORC2 Q13416 ENST00000234296 K02604 1 0.48838 1.0535 0.46782 0.639 0.66532 0.61703 Ank;Pkinase_Tyr adherens junction;anchoring junction;cell junction;cell part;cell-substrate adherens junction;cell-substrate junction;cytoplasm;focal adhesion;intracellular part;membrane part;plasma membrane part ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;protein tyrosine kinase activity;purine nucleoside binding;transferase activity cell adhesion;cell communication;cell surface receptor linked signal transduction;cell-matrix adhesion;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;signal transduction Endometrial cancer;Focal adhesion;PPAR signaling pathway 20 20 20 47.1 47.1 47.1 51.419 4.0976E-195 241980000 126840000 115140000 1081 IPI:IPI00013219.1 Integrin-linked protein kinase;ILK-1;ILK-2;59 kDa serine/threonine-protein kinase;p59ILK ILK;ILK1;ILK2 Q13418 ENST00000299421;ENST00000396751 K06272 1 0.59344 1.5983 0.91544 0.73945 1.1408 1.1509 FBA;F-box binding;protein binding catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 3 3 3 17.4 17.4 17.4 25.698 6.8442E-06 13904000 7453600 6449900 1083 IPI:IPI00013239.1;IPI:IPI00171291.1;IPI:IPI00414844.3 F-box only protein 44;F-box/G-domain protein 3;F-box protein FBX30 FBXO44;FBG3;FBX30;FBX44;FBX6A;FBXO6A Q9H4M3-2;Q9H4M3 ENST00000251546;ENST00000251547;ENST00000376762;ENST00000376768;ENST00000376770 K10103 3 1.0657 1.874 0.8964 1.3062 1.3124 1.1983 cell part;cytoplasm;intracellular part catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 2 2 2 28.8 28.8 28.8 8.5468 3.0575E-09 55668000 30389000 25278000 1084 IPI:IPI00013241.1 Ubiquitin-like protein 5 UBL5 Q9BZL1 ENST00000358666;ENST00000393848 1 0.72935 1.425 0.76137 0.94303 0.94343 0.96546 RRM_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 12 12 7 27 27 18.9 60.959 5.8036E-94 714480000 376180000 338300000 1085 IPI:IPI00013256.1;IPI:IPI00607841.1 Cleavage stimulation factor 64 kDa subunit;CF-1 64 kDa subunit CSTF2 P33240-1;P33240;P33240-2 ENST00000372972 2 0.96233 1.5882 0.97448 1.1807 1.1405 1.2006 DER1 integral to endoplasmic reticulum membrane;integral to membrane;integral to organelle membrane;intracellular part;intrinsic to endoplasmic reticulum membrane;intrinsic to membrane;intrinsic to organelle membrane;membrane part;organelle part binding;MHC class I protein binding;MHC protein binding;molecular transducer activity;protein binding;receptor activity;receptor binding;signal transducer activity ER-nuclear signaling pathway;intracellular protein transport;misfolded or incompletely synthesized protein catabolic process;proteolysis;response to stress;response to unfolded protein;transport;ubiquitin-dependent protein catabolic process 2 2 2 10 10 10 28.8 3.0203E-11 24979000 13290000 11688000 1088 IPI:IPI00013271.1 Derlin-1;Der1-like protein 1;Degradation in endoplasmic reticulum protein 1 DERL1;DER1;UNQ243/PRO276 Q9BUN8 ENST00000259512 1 0.84236 1.5416 0.83355 1.1253 0.98646 1.0609 GRIP cell part;cytoplasmic part;Golgi apparatus part;Golgi membrane;intracellular organelle part;intracellular part;membrane;organelle membrane;organelle part;trans-Golgi network cellular process;establishment of localization;transport;vesicle-mediated transport 7 7 7 3.7 3.7 3.7 262.33 1.6942E-32 308500000 159010000 149490000 1089 IPI:IPI00927614.1;IPI:IPI00013272.1;IPI:IPI00220522.1 Golgin subfamily A member 4;Trans-Golgi p230;256 kDa golgin;Golgin-245;Protein 72.1 GOLGA4 Q13439-3;Q13439;Q13439-1;Q13439-4 ENST00000273176;ENST00000356847;ENST00000361924 3 0.1497 0.27596 0.20448 0.18743 0.19688 0.26465 F-box binding;protein binding cell cycle process;cell proliferation;cellular process;G1/S transition of mitotic cell cycle Cell cycle;Pathways in cancer;Small cell lung cancer;Ubiquitin mediated proteolysis 5 5 5 12.7 12.7 12.7 47.76 6.2009E-29 28548000 20683000 7865300 1090 IPI:IPI00178899.1;IPI:IPI00013294.1 S-phase kinase-associated protein 2;F-box protein Skp2;Cyclin A/CDK2-associated protein p45;p45skp2;F-box/LRR-repeat protein 1 SKP2;FBXL1 Q13309-1;Q13309;Q13309-2 ENST00000274254;ENST00000274255;ENST00000308927 K03875 2 0.7279 1.2892 0.75155 0.94764 0.88239 0.94677 Ribosomal_S13 cell part;cytoplasmic part;cytosolic part;cytosolic small ribosomal subunit;intracellular organelle part;intracellular part;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit binding;nucleic acid binding;RNA binding;rRNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 23 23 23 77.6 77.6 77.6 17.718 1.2667E-129 6330200000 3375800000 2954300000 1091 IPI:IPI00013296.3 40S ribosomal protein S18;Ke-3 RPS18;D6S218E P62269 ENST00000211372;ENST00000374631;ENST00000383076 K02964 1 0.85011 1.5297 0.70824 1.0415 0.9534 1.035 PP28 biological regulation;cell communication;cell proliferation;cellular process;regulation of biological process;regulation of cellular process;signal transduction 11 11 11 40.9 40.9 40.9 20.63 1.7271E-76 519940000 273460000 246470000 1092 IPI:IPI00013297.1 28 kDa heat- and acid-stable phosphoprotein;PDGF-associated protein;PDGFA-associated protein 1 PDAP1;HASPP28 Q13442 ENST00000350498 1 0.43518 0.9567 0.66224 0.58774 0.68202 0.81748 Topoisom_bac;Toprim;zf-C4_Topoisom;zf-GRF cell part;chromosome;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear body;nuclear part;nucleoplasm part;organelle;organelle part;PML body ATP binding;binding;catalytic activity;DNA binding;DNA topoisomerase activity;DNA topoisomerase type I activity;isomerase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;zinc ion binding cell cycle process;cellular process;DNA metabolic process;DNA topological change;DNA unwinding during replication;meiosis;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Homologous recombination 5 5 4 6.4 6.4 5.3 112.37 9.1746E-32 27621000 14567000 13054000 1096 IPI:IPI00013378.1;IPI:IPI00221295.1 DNA topoisomerase 3-alpha;DNA topoisomerase III alpha TOP3A;TOP3 Q13472-1;Q13472;Q13472-2 ENST00000321105 K03165 2 0.91976 1.4553 0.91149 1.1401 0.99379 1.1281 zf-U1 Cajal body;cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear body;nuclear part;nucleoplasm part;organelle part;ribonucleoprotein complex;small nuclear ribonucleoprotein complex;U1 snRNP binding;cation binding;identical protein binding;ion binding;metal ion binding;nucleic acid binding;protein binding;protein homodimerization activity;RNA binding;single-stranded RNA binding;transition metal ion binding;zinc ion binding cellular component biogenesis;cellular process;ribonucleoprotein complex biogenesis;spliceosomal snRNP biogenesis 3 3 3 19.5 19.5 19.5 17.394 7.0008E-136 347570000 184110000 163450000 1097 IPI:IPI00013396.3 U1 small nuclear ribonucleoprotein C SNRPC P09234 ENST00000244520;ENST00000374017 K11095 1 0.65746 1.6218 0.6635 0.90267 1.0641 0.90218 Ribosomal_S7e cytosolic small ribosomal subunit;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nucleolus;organelle;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit binding;nucleic acid binding;protein binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA processing;rRNA processing;translational elongation Ribosome 15 15 15 64.9 64.9 64.9 22.127 0 1613900000 874630000 739260000 1099 IPI:IPI00013415.1 40S ribosomal protein S7 RPS7 P62081 ENST00000304921;ENST00000403564;ENST00000406376 K02993 1 NaN 0.88695 0.37122 NaN 0.57104 0.48959 C1-set cell part;extracellular region;membrane immune response;immune system process;response to stimulus 2 2 2 7.5 7.5 7.5 22.963 1.3249E-33 25621000 14456000 11165000 1100 IPI:IPI00013438.1 Immunoglobulin lambda-like polypeptide 1;Immunoglobulin-related protein 14.1;Immunoglobulin omega polypeptide;Ig lambda-5;CD179 antigen-like family member B IGLL1;IGL1 P15814 ENST00000330377 K06554 1 0.76164 1.6203 0.75568 1.0466 0.99774 0.98962 HGTP_anticodon;ProRS-C_1;tRNA-synt_1c;tRNA-synt_1c_C;tRNA-synt_2b;WHEP-TRS cell fraction;cell part;cytoplasm;intracellular part;soluble fraction aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;glutamate-tRNA ligase activity;nucleic acid binding;nucleoside binding;nucleotide binding;proline-tRNA ligase activity;protein binding;purine nucleoside binding;RNA binding glutamyl-tRNA aminoacylation;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;prolyl-tRNA aminoacylation;protein complex assembly;tRNA aminoacylation for protein translation;tRNA metabolic process Aminoacyl-tRNA biosynthesis;Glutamate metabolism;Porphyrin and chlorophyll metabolism 76 76 76 60.6 60.6 60.6 170.6 0 5952400000 3196200000 2756200000 1101 IPI:IPI00013452.10 Bifunctional aminoacyl-tRNA synthetase;Proliferation-inducing gene 32 protein;Glutamyl-tRNA synthetase;Glutamate--tRNA ligase;Prolyl-tRNA synthetase;Proline--tRNA ligase EPRS;GLNS;PARS;QARS;QPRS;PIG32 P07814 ENST00000366923 K01881;K01885 1 0.73317 1.305 0.71201 0.98555 0.81365 0.95948 RGS binding;molecular transducer activity;protein binding;signal transducer activity negative regulation of biological process;negative regulation of cell communication;negative regulation of cellular process;negative regulation of signal transduction;regulation of cell communication;regulation of signal transduction 5 5 5 30.4 30.4 30.4 21.21 7.8563E-20 105140000 56702000 48441000 1102 IPI:IPI00643554.1;IPI:IPI00013454.4;IPI:IPI00216532.1 Regulator of G-protein signaling 10 RGS10 O43665-3;O43665;O43665-1;O43665-2 ENST00000369101;ENST00000369103;ENST00000392865 3 0.82173 1.8997 1.2132 1.1058 1.2032 1.56 CAP_GLY endosome;intermediate filament;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;kinetochore;macromolecular complex;membrane-bounded organelle;microtubule;non-membrane-bounded organelle;organelle binding;cation binding;cytoskeletal protein binding;identical protein binding;ion binding;metal ion binding;microtubule binding;nucleic acid binding;protein binding;protein homodimerization activity;tubulin binding;zinc ion binding cell cycle phase;cell cycle process;cellular component organization;cellular process;mitosis;nuclear division;organelle fission;organelle organization 8 8 8 7.1 7.1 7.1 162.24 6.666E-22 67611000 35239000 32372000 1103 IPI:IPI00013455.8;IPI:IPI00027172.1;IPI:IPI00217113.1 CAP-Gly domain-containing linker protein 1;Restin;Cytoplasmic linker protein 170 alpha-2;Reed-Sternberg intermediate filament-associated protein;Cytoplasmic linker protein 1 CLIP1;CYLN1;RSN P30622-3;P30622;P30622-1;P30622-2 ENST00000302528;ENST00000358808;ENST00000361654 K10421 3 0.95232 1.7802 0.85006 1.2396 1.1936 1.1517 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;transcription factor activity;transcription regulator activity;transition metal ion binding;zinc ion binding regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent 7 7 7 18.2 18.2 18.2 50.75 3.098E-87 416910000 212710000 204200000 1104 IPI:IPI00013457.1;IPI:IPI00219759.1;IPI:IPI00219760.1 Zinc finger protein 207 ZNF207 O43670-1;O43670;O43670-2;O43670-3 ENST00000321233;ENST00000341711;ENST00000342555;ENST00000394679 3 NaN 1.5443 0.83756 NaN 0.96696 1.0974 NDUF_B5 cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;macromolecular complex;membrane part;mitochondrial part;mitochondrial respiratory chain complex I;NADH dehydrogenase complex;organelle part;protein complex catalytic activity;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor cellular metabolic process;cellular process;electron transport chain;generation of precursor metabolites and energy;metabolic process;mitochondrial electron transport, NADH to ubiquinone;respiratory electron transport chain;transport Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 3 3 3 12.2 12.2 12.2 21.75 1.0779E-14 47697000 27098000 20598000 1105 IPI:IPI00013459.1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial;NADH-ubiquinone oxidoreductase SGDH subunit;Complex I-SGDH NDUFB5 O43674 ENST00000259037 K03961 1 0.73635 1.5586 0.85749 0.97492 1.1117 1.0789 ArsA_ATPase cell fraction;cell part;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;soluble fraction arsenite secondary active transmembrane transporter activity;ATP binding;binding;catalytic activity;cation transmembrane transporter activity;nucleoside binding;nucleotide binding;purine nucleoside binding;transporter activity cellular cation homeostasis;cellular homeostasis;cellular ion homeostasis;cellular metal ion homeostasis;cellular process;chemical homeostasis;homeostatic process;response to arsenic;response to chemical stimulus;response to inorganic substance;transport 13 13 13 44.8 44.8 44.8 38.792 1.3036E-186 759780000 402390000 357390000 1106 IPI:IPI00013466.4 Arsenical pump-driving ATPase;Arsenite-translocating ATPase;Arsenical resistance ATPase;Arsenite-transporting ATPase ASNA1;ARSA O43681 ENST00000357332 K01551 1 1.0235 1.6427 1.0059 1.2608 1.1443 1.2787 WD40 cytosol;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;kinetochore;macromolecular complex;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle;protein complex binding;protein binding catabolic process;cell cycle checkpoint;cell proliferation;metabolic process;mitosis;mitotic cell cycle checkpoint;nuclear division;organelle organization;proteolysis;regulation of mitotic cell cycle;ubiquitin-dependent protein catabolic process 12 12 12 46.6 46.6 46.6 37.154 5.5603E-283 1806900000 896450000 910450000 1107 IPI:IPI00013468.1 Mitotic checkpoint protein BUB3 BUB3 O43684 ENST00000368865 1 0.89929 1.5713 0.84765 1.177 1.027 1.0985 Tubulin;Tubulin_C cell part;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;microtubule;organelle part;protein complex binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity;structural molecule activity anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;microtubule-based movement;microtubule-based process;protein complex assembly Gap junction 28 8 7 65.8 25.2 22.5 49.906 0 877700000 460430000 417280000 1108 IPI:IPI00013475.1;IPI:IPI00031370.3 Tubulin beta-2A chain;Tubulin beta-2B chain TUBB2A;TUBB2;TUBB2B Q13885;Q9BVA1 ENST00000333628;ENST00000259818 K07375 2 0.7053 1.3527 0.65879 0.91992 0.88661 0.91002 Ribosomal_S5;Ribosomal_S5_C cell part;cytoplasmic part;cytosolic part;cytosolic small ribosomal subunit;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit binding;fibroblast growth factor 1 binding;fibroblast growth factor 3 binding;fibroblast growth factor binding;growth factor binding;nucleic acid binding;protein binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 14 14 14 48.8 48.8 48.8 31.324 1.8254E-270 4633900000 2513900000 2120000000 1109 IPI:IPI00013485.3 40S ribosomal protein S2;S4;LLRep3 protein RPS2;RPS4 P15880 ENST00000343262 K02981 1 0.69303 1.3204 0.63398 0.93428 0.90623 0.86953 ABC_tran ATP binding;binding;catalytic activity;nucleic acid binding;nucleoside binding;nucleotide binding;primary active transmembrane transporter activity;purine nucleoside binding;translation factor activity, nucleic acid binding;transporter activity biosynthetic process;cellular process;defense response;inflammatory response;macromolecule biosynthetic process;metabolic process;protein metabolic process;response to external stimulus;response to stress;response to wounding;translation 16 16 16 20.9 20.9 20.9 95.925 1.5365E-217 476060000 241300000 234760000 1110 IPI:IPI00873899.1;IPI:IPI00013495.1 ATP-binding cassette sub-family F member 1;ATP-binding cassette 50;TNF-alpha-stimulated ABC protein ABCF1;ABC50 Q8NE71-1;Q8NE71;Q8NE71-2 ENST00000326195;ENST00000376545;ENST00000383437;ENST00000383588 K06184 2 0.83176 1.6178 0.82029 1.1151 1.0566 1.0967 CH;efhand;efhand_Ca_insen;Spectrin adherens junction;cell junction;cell projection;cell-substrate adherens junction;cell-substrate junction;cytoskeleton;focal adhesion;intracellular organelle;non-membrane-bounded organelle;nucleolus;organelle;pseudopodium;Z disc actin binding;binding;calcium ion binding;cation binding;cytoskeletal protein binding;integrin binding;ion binding;metal ion binding;protein binding;protein complex binding;receptor binding;vinculin binding anatomical structure formation;cell junction assembly;cell junction organization;cell-substrate junction assembly;cellular component assembly;cellular component organization;cellular process;regulation of cell death;regulation of localization Adherens junction;Focal adhesion;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Systemic lupus erythematosus;Tight junction 46 27 27 59.1 39.3 39.3 103.06 0 2458000000 1249400000 1208600000 1111 IPI:IPI00013508.5;IPI:IPI00019884.1;IPI:IPI00032137.2 Alpha-actinin-1;Alpha-actinin cytoskeletal isoform;Non-muscle alpha-actinin-1;F-actin cross-linking protein ACTN1 P12814 ENST00000193403;ENST00000394419 K05699 3 0.75212 1.5357 0.79408 1.0295 1.0299 1.0265 Tom37 cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial membrane;mitochondrial outer membrane;mitochondrial part;organelle membrane;organelle outer membrane;organelle part;outer membrane binding;protein binding establishment of localization;establishment of protein localization;intracellular protein transport;intracellular transport;mitochondrial transport;protein import;protein targeting;protein targeting to mitochondrion;protein transport;transport 10 10 10 22.1 22.1 22.1 51.476 1.2141E-89 241510000 127620000 113880000 1113 IPI:IPI00013678.2;IPI:IPI00914855.1;IPI:IPI00394889.5 Metaxin-1;Mitochondrial outer membrane import complex protein 1 MTX1;MTX;MTXN Q13505-1;Q13505;Q13505-3;Q13505-2 ENST00000368376 3 0.78508 1.8583 0.84334 1.0803 1.2019 1.0608 7tm_1;Tubulin;Tubulin_C cell part;cytoskeletal part;integral to membrane;integral to plasma membrane;intracellular part;intrinsic to membrane;intrinsic to plasma membrane;macromolecular complex;membrane part;microtubule;organelle part;plasma membrane part;protein complex binding;G-protein coupled receptor activity;melanocortin receptor activity;melanocyte stimulating hormone receptor activity;peptide receptor activity;receptor activity;signal transducer activity;transmembrane receptor activity cell communication;cell surface receptor linked signal transduction;G-protein coupled receptor protein signaling pathway;G-protein signaling, coupled to cyclic nucleotide second messenger;intracellular signaling cascade;signal transduction Gap junction;Melanogenesis;Neuroactive ligand-receptor interaction 20 6 4 26.3 11 8.2 88.381 0 248410000 121310000 127110000 1115 IPI:IPI00152453.1;IPI:IPI00013683.2 Melanocyte-stimulating hormone receptor;Melanotropin receptor;Melanocortin receptor 1;MC1-R;Tubulin beta-3 chain;Tubulin beta-III;Tubulin beta-4 MC1R;MSHR;TUBB3;TUBB4 Q01726;Q13509 ENST00000304984;ENST00000315491 K04199;K07375 2 0.91293 1.8788 0.84158 1.135 1.2357 1.1625 CBAH cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;lysosome;lytic vacuole;membrane-bounded organelle;organelle;vacuole catalytic activity;ceramidase activity;hydrolase activity;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides cellular lipid metabolic process;cellular metabolic process;cellular process;ceramide metabolic process;lipid metabolic process;membrane lipid metabolic process;metabolic process;primary metabolic process;sphingolipid metabolic process 7 7 7 22.1 22.1 22.1 46.503 2.3827E-84 37348000 22193000 15156000 1116 IPI:IPI00418446.4;IPI:IPI00013698.2 Acid ceramidase;Acylsphingosine deacylase;N-acylsphingosine amidohydrolase;Putative 32 kDa heart protein;Acid ceramidase subunit alpha;Acid ceramidase subunit beta ASAH1;ASAH;HSD33;HSD-33 Q13510-2;Q13510;Q13510-1 ENST00000262097;ENST00000381733 2 0.76123 1.6518 0.72851 1.0385 1.0815 0.98883 Ribosomal_L20 intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;mitochondrion;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome binding;nucleic acid binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 3 3 3 19.5 19.5 19.5 17.442 8.2308E-16 34499000 23082000 11417000 1117 IPI:IPI00013706.5 39S ribosomal protein L20, mitochondrial MRPL20 Q9BYC9 ENST00000344843;ENST00000400819 1 0.48998 1.3312 0.53844 0.74035 0.84839 0.74802 Pkinase cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity mRNA processing;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;RNA processing 14 14 14 14.8 14.8 14.8 116.97 1.0244E-74 253140000 137740000 115400000 1118 IPI:IPI00013721.2 Serine/threonine-protein kinase PRP4 homolog;PRP4 pre-mRNA-processing factor 4 homolog;PRP4 kinase PRPF4B;KIAA0536;PRP4;PRP4H;PRP4K Q13523 ENST00000337659 K08827 1 0.8007 1.7842 0.86117 1.094 1.1295 1.1513 Rotamase;WW cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle amine binding;amino acid binding;binding;carboxylic acid binding;catalytic activity;cis-trans isomerase activity;isomerase activity;peptidyl-prolyl cis-trans isomerase activity;protein binding;protein phosphorylated amino acid binding;SMAD binding cell cycle;cellular process;metabolic process;negative regulation of signal transduction;protein folding;regulation of mitosis;regulation of mitotic cell cycle;regulation of protein amino acid phosphorylation;regulation of signal transduction 6 6 6 57.7 57.7 57.7 18.243 3.4758E-185 740620000 393000000 347620000 1119 IPI:IPI00013723.3;IPI:IPI00006667.1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1;Rotamase Pin1;PPIase Pin1 PIN1 Q13526 ENST00000247970 K09578 2 0.70611 1.283 0.7327 0.95556 0.85379 0.98103 FAST_1;FAST_2;RAP ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups apoptosis;cell death;cellular process;death;programmed cell death 14 14 14 22.1 22.1 22.1 81.462 1.1969E-233 131490000 70113000 61374000 1120 IPI:IPI00013735.1;IPI:IPI00479951.4 FAST kinase domain-containing protein 2 FASTKD2;KIAA0971 Q9NYY8-1;Q9NYY8;Q9NYY8-2 ENST00000236980;ENST00000402774;ENST00000403094 2 0.70605 1.2465 0.69077 0.87321 0.83688 0.93722 DUF2050 5 5 5 8.1 8.1 8.1 70.52 2.2545E-21 53739000 28621000 25118000 1121 IPI:IPI00013743.4;IPI:IPI00387050.4 BUD13 homolog BUD13 Q9BRD0-1;Q9BRD0;Q9BRD0-2 ENST00000260210 2 NaN 0.372 NaN NaN 0.22485 NaN Death;Pkinase cytosol;death-inducing signaling complex;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane part;membrane-bounded organelle;mitochondrion;organelle;protein complex;receptor complex binding;catalytic activity;cytokine receptor binding;death receptor binding;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;protein tyrosine kinase activity;purine nucleoside binding;receptor binding activation of MAPK activity;cell communication;induction of apoptosis;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;regulation of protein amino acid phosphorylation Apoptosis;Toll-like receptor signaling pathway 3 3 3 5.7 5.7 5.7 75.93 4.7701E-08 13189000 7499100 5690100 1123 IPI:IPI00013773.2;IPI:IPI00939198.1 Receptor-interacting serine/threonine-protein kinase 1;Serine/threonine-protein kinase RIP;Cell death protein RIP;Receptor-interacting protein RIPK1;RIP Q13546-1;Q13546;Q13546-2 ENST00000259808;ENST00000380409 K02861 2 0.81424 1.4784 0.73176 1.025 0.97891 0.97765 Hist_deacetyl cell part;chromatin remodeling complex;cytoplasm;histone deacetylase complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;catalytic activity;DNA binding;histone deacetylase activity;hydrolase activity;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;nucleic acid binding;protein binding;transcription factor activity;transcription factor binding chromatin organization;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein amino acid deacetylation;protein modification process;regulation of transcription, DNA-dependent;transcription Cell cycle;Chronic myeloid leukemia;Huntington's disease;Notch signaling pathway;Pathways in cancer 13 12 8 36.3 35.1 26.1 55.102 0 1487900000 773860000 714020000 1124 IPI:IPI00013774.1 Histone deacetylase 1 HDAC1;RPD3L1 Q13547 ENST00000373548 K06067 1 0.74854 1.5584 0.76823 1.0167 1.0261 1.0351 RRM_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding;RNA polymerase II transcription factor activity;transcription elongation regulator activity;transcription regulator activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 12 12 12 17.5 17.5 17.5 85.852 1.6485E-90 390850000 206970000 183880000 1125 IPI:IPI00013788.1 HIV Tat-specific factor 1 HTATSF1 O43719 ENST00000218364 1 0.76148 1.6269 0.82373 0.99393 1.0627 1.0788 SET binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding 6 6 6 21.5 21.5 21.5 47.34 1.3296E-21 190830000 100880000 89948000 1126 IPI:IPI00013789.5 SET and MYND domain-containing protein 5;Retinoic acid-induced protein 15;Protein NN8-4AG SMYD5;RAI15 Q6GMV2 ENST00000389501 1 0.82347 1.6401 0.81061 1.0487 1.0848 1.0647 CH;efhand;efhand_Ca_insen;Spectrin cell projection;cytoplasmic part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;protein complex;pseudopodium actin binding;binding;calcium ion binding;cation binding;cytoskeletal protein binding;identical protein binding;integrin binding;ion binding;nucleoside binding;protein binding;protein complex binding;protein homodimerization activity;receptor binding positive regulation of transporter activity;regulation of cell death;regulation of ion transmembrane transporter activity;regulation of transmembrane transporter activity;regulation of transporter activity Adherens junction;Focal adhesion;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Systemic lupus erythematosus;Tight junction 48 48 28 59.8 59.8 40.9 104.85 0 4419900000 2310500000 2109400000 1127 IPI:IPI00013808.1 Alpha-actinin-4;Non-muscle alpha-actinin 4;F-actin cross-linking protein ACTN4 O43707 ENST00000252699 K05699 1 NaN NaN 0.84961 NaN NaN 1.0378 GST_C;GST_N cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle antioxidant activity;binding;catalytic activity;glutathione peroxidase activity;glutathione transferase activity;maleylacetoacetate isomerase activity;oxidoreductase activity;peroxidase activity;protein binding cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;L-phenylalanine catabolic process;L-phenylalanine metabolic process;organic acid metabolic process;tyrosine catabolic process;tyrosine metabolic process Drug metabolism - cytochrome P450;Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450;Styrene degradation;Tyrosine metabolism 4 4 4 29.2 29.2 29.2 24.212 9.6431E-127 6354200 3494400 2859900 1128 IPI:IPI00013809.2 Maleylacetoacetate isomerase;Glutathione S-transferase zeta 1;GSTZ1-1 GSTZ1;MAAI O43708 ENST00000216465;ENST00000393741 K00799;K01800 1 0.55594 0.99288 0.52156 0.73648 0.62776 0.70579 Methyltransf_11 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle catalytic activity;methyltransferase activity;transferase activity;transferase activity, transferring one-carbon groups metabolic process Aminophosphonate metabolism;Androgen and estrogen metabolism;Histidine metabolism;Naphthalene and anthracene degradation;Selenoamino acid metabolism;Tyrosine metabolism 4 4 4 19.9 19.9 19.9 31.88 4.9785E-69 63283000 33342000 29941000 1129 IPI:IPI00013810.2 Uncharacterized methyltransferase WBSCR22;Williams-Beuren syndrome chromosomal region 22 protein WBSCR22;HUSSY-03;PP3381 O43709-1;O43709 ENST00000265758 K00599 1 NaN 1.3832 0.66806 NaN 0.85473 0.98173 UPF0203 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle;perinuclear region of cytoplasm binding;caspase inhibitor activity;caspase regulator activity;cysteine-type endopeptidase inhibitor activity;endopeptidase inhibitor activity;enzyme inhibitor activity;enzyme regulator activity;peptidase inhibitor activity;protein binding anti-apoptosis;apoptosis;cell communication;cell death;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;intracellular signaling cascade;response to DNA damage stimulus;response to stress;signal transduction 2 2 2 38.2 38.2 38.2 8.7858 2.4283E-19 4977400 2690400 2287000 1130 IPI:IPI00013829.1 TP53-regulated inhibitor of apoptosis 1;p53-inducible cell-survival factor;Protein 15E1.1;WF-1 TRIAP1;15E1.1;HSPC132 O43715 ENST00000302432 1 0.79092 1.4853 0.81526 1.1201 0.92817 1.0869 SKIP_SNW cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;Notch binding;protein binding;receptor binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding;transcription regulator activity nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile Notch signaling pathway 9 9 9 19.8 19.8 19.8 61.494 6.1892E-130 329750000 170130000 159620000 1131 IPI:IPI00013830.1 SNW domain-containing protein 1;Nuclear protein SkiP;Ski-interacting protein;Nuclear receptor coactivator NCoA-62 SNW1;SKIIP;SKIP Q13573 ENST00000261531 K06063 1 0.70416 1.5274 NaN 0.95898 0.99752 NaN Glu-tRNAGln regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of translation;regulation of translational elongation;regulation of translational fidelity 5 5 5 43.4 43.4 43.4 15.086 1.0295E-23 21971000 12538000 9433000 1133 IPI:IPI00013832.3 GatC-like protein;Protein 15E1.2 GATC;15E1.2 O43716 ENST00000229384;ENST00000406065 1 0.72786 1.3992 0.7045 0.91438 0.92567 0.96499 Ank;C1_1;DAGK_acc;DAGK_cat cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;nucleus;organelle;plasma membrane ATP binding;binding;catalytic activity;diacylglycerol kinase activity;kinase activity;lipid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;transferase activity;zinc ion binding activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway;cell communication;cell surface receptor linked signal transduction;G-protein coupled receptor protein signaling pathway;signal transduction Glycerolipid metabolism;Glycerophospholipid metabolism;Phosphatidylinositol signaling system 6 6 6 7.5 7.5 7.5 124.13 6.0616E-73 33578000 17761000 15817000 1134 IPI:IPI00013835.4;IPI:IPI00300125.3 Diacylglycerol kinase zeta;Diglyceride kinase zeta DGKZ;DAGK6 Q13574-1;Q13574;Q13574-2 ENST00000318201;ENST00000343674 K00901 2 0.73466 1.2928 0.72062 0.94337 0.92 0.92292 Peptidase_M16;Peptidase_M16_C cell part;cytoplasmic part;intracellular organelle part;intracellular part;membrane part;mitochondrial membrane part;mitochondrial part;mitochondrial respiratory chain;organelle part;respiratory chain binding;catalytic activity;endopeptidase activity;metalloendopeptidase activity;metallopeptidase activity;peptidase activity;protein binding;transporter activity;ubiquinol-cytochrome-c reductase activity;zinc ion binding aerobic respiration;catabolic process;cellular process;energy derivation by oxidation of organic compounds;generation of precursor metabolites and energy;macromolecule catabolic process;metabolic process;protein metabolic process;proteolysis;transport Alzheimer's disease;Cardiac muscle contraction;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 16 16 16 43.5 43.5 43.5 52.645 0 2391400000 1271500000 1119900000 1135 IPI:IPI00013847.4 Cytochrome b-c1 complex subunit 1, mitochondrial;Ubiquinol-cytochrome-c reductase complex core protein 1;Complex III subunit 1 UQCRC1 P31930 ENST00000203407 K00414 1 NaN 1.6781 NaN NaN 1.0967 NaN NAD_binding_2 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle 3-hydroxyisobutyrate dehydrogenase activity;binding;catalytic activity;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;phosphogluconate dehydrogenase (decarboxylating) activity alcohol metabolic process;carbohydrate metabolic process;glucose catabolic process;glucose metabolic process;monosaccharide metabolic process;organic acid metabolic process;pentose-phosphate shunt Valine, leucine and isoleucine degradation 4 4 4 17.3 17.3 17.3 35.329 2.1438E-159 914610 545610 369000 1136 IPI:IPI00013860.3 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH P31937 ENST00000265395 K00020 1 0.706 1.5616 0.71498 0.90743 1.0371 0.96077 Thymidylate_kin cell part;cytoplasmic part;cytosol;intracellular part ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;thymidylate kinase activity;transferase activity;transferase activity, transferring phosphorus-containing groups alcohol metabolic process;carbohydrate metabolic process;D-ribose metabolic process;monosaccharide metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;pyrimidine nucleotide metabolic process Pyrimidine metabolism 16 16 16 64.6 64.6 64.6 23.819 7.9287E-92 921940000 499590000 422350000 1137 IPI:IPI00013862.7 Thymidylate kinase;dTMP kinase DTYMK;CDC8;TMPK;TYMK P23919 ENST00000305784;ENST00000400770 K00943 1 0.9461 1.6735 0.96514 1.3251 1.1139 1.3396 SH2;SH3_1 cell part;cytoplasm;intracellular part binding;molecular adaptor activity;molecular transducer activity;protein binding;protein binding, bridging;SH3/SH2 adaptor activity;signal transducer activity cell communication;cell-cell signaling;cellular process;intracellular signaling cascade;Ras protein signal transduction;regulation of biological process;regulation of cellular process;signal transduction;small GTPase mediated signal transduction 6 6 6 24.9 24.9 24.9 25.336 8.6568E-15 23722000 12841000 10881000 1138 IPI:IPI00013864.1;IPI:IPI00886800.2 GRB2-related adapter protein GRAP Q13588 ENST00000284154 2 0.55882 0.97467 0.54214 0.74674 0.63344 0.7003 ATP-cone;Ribonuc_red_lgC;Ribonuc_red_lgN cell part;cytoplasmic part;cytosol;intracellular part;macromolecular complex;protein complex;ribonucleoside-diphosphate reductase complex ATP binding;binding;catalytic activity;nucleoside binding;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on CH or CH2 groups;purine nucleoside binding;ribonucleoside-diphosphate reductase activity biosynthetic process;cellular process;DNA metabolic process;DNA replication;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Glutathione metabolism;Purine metabolism;Pyrimidine metabolism 22 22 22 37.4 37.4 37.4 90.069 0 910440000 498300000 412140000 1139 IPI:IPI00013871.1 Ribonucleoside-diphosphate reductase large subunit;Ribonucleoside-diphosphate reductase subunit M1;Ribonucleotide reductase large subunit RRM1;RR1 P23921 ENST00000300738 K10807 1 0.77232 1.2863 0.77507 0.96966 0.90118 0.96689 RRM_1 cell part;heterogeneous nuclear ribonucleoprotein complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 13 13 13 48.8 48.8 48.8 36.926 1.2293E-269 2235100000 1161500000 1073700000 1140 IPI:IPI00013877.2;IPI:IPI00216492.1;IPI:IPI00216493.1;IPI:IPI00216494.1;IPI:IPI00216495.1;IPI:IPI00216496.1 Heterogeneous nuclear ribonucleoprotein H3 HNRNPH3;HNRPH3 P31942-1;P31942;P31942-2;P31942-3;P31942-4 ENST00000265866 6 0.78512 1.3438 0.79362 0.98614 0.93263 0.98476 RRM_1;zf-RNPHF cytoskeleton;heterogeneous nuclear ribonucleoprotein complex;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nucleoplasm;organelle;ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;nucleotide binding;poly(U) RNA binding;poly-pyrimidine tract binding;protein binding;RNA binding;single-stranded RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 17 17 10 48.8 48.8 29.8 49.229 0 14427000000 7441400000 6986000000 1141 IPI:IPI00013881.6;IPI:IPI00302133.2 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed HNRNPH1;HNRPH;HNRPH1 P31943 ENST00000329433;ENST00000356731;ENST00000393432 2 0.84 1.4513 0.82884 1.0758 1.0049 1.0727 RRM_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;nucleotide binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 7 6 6 26.2 23.4 23.4 32.688 2.1468E-143 539980000 281260000 258720000 1143 IPI:IPI00013891.1;IPI:IPI00220447.1 Transformer-2 protein homolog alpha;Transformer-2 protein homolog A TRA2A Q13595-1;Q13595;Q13595-2 ENST00000297071 2 1.1337 2.3879 1.1939 1.4965 1.5093 1.5811 TPR_1 cell part;cytoplasmic part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding response to stimulus;response to stress 53 53 53 66.5 66.5 66.5 62.639 0 13410000000 6475700000 6934700000 1144 IPI:IPI00013894.1 Stress-induced-phosphoprotein 1;Hsc70/Hsp90-organizing protein;Transformation-sensitive protein IEF SSP 3521;NY-REN-11 antigen STIP1 P31948 ENST00000305218;ENST00000358794;ENST00000394563 K09553 1 0.94338 1.5697 0.93044 1.2329 1.0849 1.1736 Disintegrin;Pep_M12B_propep;Reprolysin cell surface;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;endomembrane system;Golgi-associated vesicle;integral to membrane;intrinsic to membrane;membrane;membrane-bounded vesicle;nucleus;organelle;plasma membrane;vesicle binding;catalytic activity;endopeptidase activity;enzyme binding;hydrolase activity;integrin binding;metalloendopeptidase activity;metallopeptidase activity;peptidase activity;protein binding;receptor binding;SH3 domain binding;zinc ion binding cell activation;immune system process;in utero embryonic development;myeloid leukocyte activation;positive regulation of immune system process;regulation of cell growth;regulation of immune system process;regulation of leukocyte migration Alzheimer's disease;Epithelial cell signaling in Helicobacter pylori infection 11 11 11 19.1 19.1 19.1 84.141 1.282E-59 100790000 51551000 49240000 1145 IPI:IPI00013897.1 Disintegrin and metalloproteinase domain-containing protein 10;Mammalian disintegrin-metalloprotease;Kuzbanian protein homolog;CDw156 ADAM10;KUZ;MADM O14672 ENST00000260408 K06704 1 0.82076 1.2579 0.60826 1.0207 0.76034 0.79269 3 3 3 13.5 13.5 13.5 36.346 2.8481E-06 8242300 4216000 4026300 1146 IPI:IPI00013912.1 Uncharacterized protein C1orf198 C1orf198 Q9H425 ENST00000366663 1 0.68096 1.4222 0.69429 0.91015 0.90946 0.92798 Ribosomal_L7Ae cell part;cytoplasmic part;cytosolic part;cytosolic small ribosomal subunit;intracellular organelle part;intracellular part;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation 11 11 11 65.2 65.2 65.2 14.515 1.6879E-194 3981700000 2128400000 1853300000 1147 IPI:IPI00013917.3 40S ribosomal protein S12 RPS12 P25398 ENST00000230050;ENST00000367905 1 NaN 1.2455 NaN NaN 0.87382 NaN HLH cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;identical protein binding;nucleic acid binding;promoter binding;protein binding;protein homodimerization activity;transcription factor activity;transcription factor binding;transcription regulator activity B cell lineage commitment;biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 3 3 3 9.6 9.6 9.6 67.6 2.5545E-30 23869000 12603000 11266000 1148 IPI:IPI00013929.1;IPI:IPI00216911.1 Transcription factor E2-alpha;Immunoglobulin enhancer-binding factor E12/E47;Transcription factor 3;Immunoglobulin transcription factor 1;Transcription factor ITF-1;Kappa-E2-binding factor TCF3;E2A;ITF1 P15923-1;P15923;P15923-2 ENST00000262965;ENST00000344749;ENST00000395423 2 0.98166 1.7836 NaN 1.4229 1.2805 NaN SNARE;Syntaxin-6_N clathrin-coated vesicle;coated vesicle;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;early endosome;endosome;Golgi membrane;integral to membrane;intrinsic to membrane;membrane;membrane-bounded vesicle;organelle membrane;plasma membrane;vesicle binding;protein binding;SNAP receptor activity cellular component organization;cellular process;intracellular protein transport;membrane fusion;membrane organization;organelle organization;protein transport;transport;vesicle fusion;vesicle organization;vesicle-mediated transport SNARE interactions in vesicular transport 2 2 2 9.4 9.4 9.4 29.176 2.9881E-11 13976000 6894200 7081500 1149 IPI:IPI00013930.1 Syntaxin-6 STX6 O43752 ENST00000258301 K08498 1 0.14938 5.2323 0.21492 0.22041 3.5983 0.26586 Plectin cell junction;cell part;cell-cell junction;cornified envelope;cytoskeleton;desmosome;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane part;non-membrane-bounded organelle;organelle;plasma membrane part binding;protein binding;protein binding, bridging;structural constituent of cytoskeleton;structural molecule activity cell differentiation;cellular process;developmental process;epidermal cell differentiation;epidermis development;keratinocyte differentiation;metabolic process;peptide cross-linking;protein metabolic process;protein modification process;tissue development + 36 36 36 12.6 12.6 12.6 331.77 5.6787E-260 164640000 134370000 30262000 1150 IPI:IPI00013933.2;IPI:IPI00217182.5 Desmoplakin;250/210 kDa paraneoplastic pemphigus antigen DSP P15924-1;P15924;P15924-2 ENST00000379802 K10381 2 0.71632 1.5272 0.70508 0.96616 0.97494 0.91644 RPA_C;tRNA_anti cell part;chromosomal part;DNA replication factor A complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear chromosome part;nuclear part;nucleoplasm;organelle part;protein complex binding;DNA binding;nucleic acid binding;protein binding;single-stranded DNA binding;structure-specific DNA binding DNA catabolic process;DNA metabolic process;DNA replication;DNA-dependent DNA replication;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleotide-excision repair, DNA damage removal;nucleotide-excision repair, DNA gap filling DNA replication;Homologous recombination;Mismatch repair;Nucleotide excision repair 5 5 5 20.1 20.1 20.1 38.809 1.4794E-111 165760000 88521000 77239000 1151 IPI:IPI00646500.1;IPI:IPI00647667.1;IPI:IPI00013939.3 Replication protein A 32 kDa subunit;RP-A p34;Replication factor A protein 2 RPA2;REPA2;RPA32;RPA34 P15927-3;P15927;P15927-2;P15927-1 ENST00000313433;ENST00000373912 K10739 3 0.76996 1.4152 0.82021 0.91733 0.99229 1.0078 MARVEL cell part;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part 2 2 2 8 8 8 24.81 2.6904E-06 52206000 27785000 24421000 1152 IPI:IPI00013946.1 Synaptogyrin-2;Cellugyrin SYNGR2;UNQ352/PRO615 O43760 ENST00000225777 1 0.73329 1.6068 0.81515 0.96986 1.0806 1.0579 TPR_1 cell part;cytoplasm;intracellular part binding;protein binding interspecies interaction between organisms;multi-organism process 7 7 7 23.6 23.6 23.6 34.063 2.2477E-125 765300000 402200000 363090000 1153 IPI:IPI00013949.1 Small glutamine-rich tetratricopeptide repeat-containing protein alpha;Alpha-SGT;Vpu-binding protein SGTA;SGT;SGT1 O43765 ENST00000221566 1 0.52212 0.512 0.92296 0.67331 0.36187 1.1277 WD40 cell part;cytoplasm;intracellular part binding;protein binding cell cycle arrest;cell cycle process;cellular process;negative regulation of biological process;negative regulation of cell proliferation;negative regulation of cellular process;regulation of biological process;regulation of cell proliferation 7 7 7 8.7 8.7 8.7 121.72 4.9652E-27 29823000 17625000 12198000 1154 IPI:IPI00013953.1 WD repeat-containing protein 6 WDR6 Q9NNW5 ENST00000315574;ENST00000395474 1 0.73049 1.8343 NaN 1.0385 1.1251 NaN Mito_carr cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part amine transmembrane transporter activity;binding;carnitine transporter activity;cation transmembrane transporter activity;ion transmembrane transporter activity;organic cation transmembrane transporter activity;transporter activity amino acid transport;carnitine shuttle;cation transport;cellular process;ion transport;lipid transport;mitochondrial transport;organic cation transport;quaternary ammonium group transport;regulation of cellular ketone metabolic process;transport 8 8 8 24.6 24.6 24.6 32.943 2.4609E-14 30345000 15768000 14577000 1155 IPI:IPI00013957.1 Mitochondrial carnitine/acylcarnitine carrier protein;Carnitine/acylcarnitine translocase;Solute carrier family 25 member 20 SLC25A20;CAC;CACT O43772 ENST00000319017 K03454 1 0.76253 1.5099 0.82899 1.0028 1.0032 1.0582 COX7C cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part catalytic activity;cation transmembrane transporter activity;cytochrome-c oxidase activity;heme-copper terminal oxidase activity;ion transmembrane transporter activity;monovalent inorganic cation transmembrane transporter activity;transporter activity cellular metabolic process;cellular process;generation of precursor metabolites and energy;metabolic process Alzheimer's disease;Cardiac muscle contraction;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 2 2 2 23.8 23.8 23.8 7.2454 0.00038559 343130000 186290000 156840000 1156 IPI:IPI00013968.1 Cytochrome c oxidase subunit 7C, mitochondrial;Cytochrome c oxidase polypeptide VIIc COX7C P15954 ENST00000247655 K02272 1 0.7224 1.7486 0.66269 0.97714 1.0934 0.88296 Porin_3 cell fraction;insoluble fraction;integral to membrane;integral to membrane of membrane fraction;integral to organelle membrane;intrinsic to membrane;intrinsic to organelle membrane;membrane fraction;mitochondrial outer membrane translocase complex anion channel activity;anion transmembrane transporter activity;binding;ion channel activity;protein binding;protein transmembrane transporter activity;transporter activity;voltage-gated anion channel activity;voltage-gated ion channel activity anion transport;establishment of protein localization;intracellular protein transport;intracellular transport;ion transport;mitochondrial transport;protein import;protein targeting;protein targeting to mitochondrion;protein transport;transport Amyotrophic lateral sclerosis (ALS) 8 8 8 38.8 38.8 38.8 37.893 1.4802E-129 584120000 327820000 256310000 1158 IPI:IPI00014053.3;IPI:IPI00376117.1 Mitochondrial import receptor subunit TOM40 homolog;Translocase of outer membrane 40 kDa subunit homolog;Protein Haymaker;p38.5 TOMM40;C19orf1;PEREC1;TOM40 O96008-1;O96008;O96008-2 ENST00000252487;ENST00000405636 K11518 2 0.97927 1.7883 1.1268 1.2852 1.2327 1.4217 PBD;Pkinase cell part;cytoplasmic part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cell communication;cell motion;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process;signal transduction Axon guidance;ErbB signaling pathway;Focal adhesion;Regulation of actin cytoskeleton;Renal cell carcinoma;T cell receptor signaling pathway 4 4 4 11.7 11.7 11.7 64.071 1.9765E-10 4383800 2299000 2084700 1159 IPI:IPI00014068.1;IPI:IPI00384231.3;IPI:IPI00556065.1;IPI:IPI00178714.2 Serine/threonine-protein kinase PAK 4;p21-activated kinase 4 PAK4;KIAA1142 O96013-1;O96013;O96013-4;O96013-3;O96013-2 ENST00000321944;ENST00000358301;ENST00000360442 K05734 4 NaN 1.136 NaN NaN 0.72159 NaN FHA;Pkinase cell part;intracellular organelle part;intracellular part;nuclear body;nuclear part;nucleoplasm part;organelle part;PML body ATP binding;binding;catalytic activity;kinase activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cell cycle;cell cycle checkpoint;DNA damage checkpoint;induction of apoptosis;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;response to DNA damage stimulus;response to stress Cell cycle;p53 signaling pathway 7 7 7 13.5 13.5 13.5 65.418 1.3473E-29 16397000 8649000 7748300 1160 IPI:IPI00423156.1;IPI:IPI00014072.1;IPI:IPI00030746.1;IPI:IPI00607709.1;IPI:IPI00423157.4;IPI:IPI00607680.1;IPI:IPI00607619.1;IPI:IPI00852660.1;IPI:IPI00607753.1;IPI:IPI00607739.1;IPI:IPI00423149.1 Serine/threonine-protein kinase Chk2;Cds1 CHEK2;CHK2;RAD53 O96017-9;O96017;O96017-1;O96017-12;O96017-4 ENST00000328354;ENST00000348295;ENST00000382556;ENST00000382563;ENST00000382565;ENST00000382566;ENST00000382578;ENST00000382580;ENST00000398017;ENST00000398021;ENST00000404276;ENST00000405598 K06641 11 NaN 0.97116 0.24541 NaN 0.5921 0.30951 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;nucleus;organelle 3 3 3 35.1 35.1 35.1 11.986 6.6977E-63 10563000 6433900 4129600 1162 IPI:IPI00014147.3 PCNA-associated factor;p15PAF;Overexpressed in anaplastic thyroid carcinoma 1;Hepatitis C virus NS5A-transactivated protein 9 PAF;KIAA0101;NS5ATP9;L5 Q15004 ENST00000300035 1 0.78119 1.5067 0.82851 0.99206 1.0346 1.0932 TPR_2 cell part;cytoplasmic part;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding 6 6 6 16.2 16.2 16.2 34.833 1.3922E-87 47890000 25737000 22153000 1163 IPI:IPI00014149.3 Tetratricopeptide repeat protein 35 TTC35;KIAA0103 Q15006 ENST00000220853 1 0.84776 1.8935 0.84684 1.1575 1.2056 1.1283 PCI;RPN7 cell part;cytoplasmic part;cytosol;intracellular part;macromolecular complex;proteasome complex;protein complex ATPase activity;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;protein binding;pyrophosphatase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Proteasome 27 27 27 57.3 57.3 57.3 45.531 0 1935400000 1012700000 922660000 1164 IPI:IPI00014151.3 26S proteasome non-ATPase regulatory subunit 6;26S proteasome regulatory subunit S10;p42A;Proteasome regulatory particle subunit p44S10;Phosphonoformate immuno-associated protein 4;Breast cancer-associated protein SGA-113M PSMD6;KIAA0107;PFAAP4 Q15008 ENST00000295901 K03037 1 0.7423 NaN 0.7479 1.0466 NaN 1.0025 MRG cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;protein binding chromatin organization;DNA metabolic process;DNA repair;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of cell growth;regulation of transcription, DNA-dependent;transcription 7 7 5 29.2 29.2 20.5 32.307 4.3979E-33 40119000 19882000 20236000 1166 IPI:IPI00014174.1 Mortality factor 4-like protein 2;MORF-related gene X protein;Transcription factor-like protein MRGX;MSL3-2 protein MORF4L2;KIAA0026;MRGX Q15014 ENST00000340782;ENST00000360458;ENST00000372619 K11342 1 0.79554 1.5069 0.8416 1.0902 1.0215 1.0797 Septin intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle;protein complex;septin complex;spindle binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;protein binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cell cycle phase;cell cycle process;cell division;cellular component organization;cellular process;mitosis;nuclear division;organelle fission;organelle organization 17 17 17 55.8 55.8 55.8 45.46 0 1241300000 638120000 603200000 1167 IPI:IPI00871851.2;IPI:IPI00014177.3 Septin-2;Neural precursor cell expressed developmentally down-regulated protein 5 SEPT2;DIFF6;KIAA0158;NEDD5 Q15019-2;Q15019;Q15019-1 ENST00000360051;ENST00000391971;ENST00000391973;ENST00000401990;ENST00000402092;ENST00000402251 2 0.68937 1.4835 0.71429 0.91416 0.97161 0.98868 cell part;cytoplasm;intracellular part cell proliferation;cellular process 9 9 9 69 69 69 27.335 0 781880000 424790000 357090000 1169 IPI:IPI00014197.2;IPI:IPI00798278.1 Protein CDV3 homolog CDV3;H41 Q9UKY7-1;Q9UKY7;Q9UKY7-2 ENST00000264993;ENST00000393122 2 0.68318 1.3748 0.50974 0.88453 0.91941 0.69588 RNase_PH;RNase_PH_C exosome (RNase complex);intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;protein complex 3'-5' exonuclease activity;3'-5'-exoribonuclease activity;binding;catalytic activity;exonuclease activity;exoribonuclease activity;hydrolase activity;nuclease activity;nucleic acid binding;protein binding;ribonuclease activity;RNA binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA catabolic process;RNA processing;rRNA processing 6 6 6 29.6 29.6 29.6 31.835 2.942E-81 104150000 58731000 45420000 1170 IPI:IPI00014198.2 Exosome complex exonuclease RRP42;Ribosomal RNA-processing protein 42;Exosome component 7;p8 EXOSC7;KIAA0116;RRP42 Q15024 ENST00000265564 1 0.72681 1.1346 0.67426 0.89176 0.79443 0.85939 Ank;ArfGap;PH ARF GTPase activator activity;binding;catalytic activity;enzyme activator activity;GTPase activator activity;phospholipase activity;phospholipase C activity;phosphoric diester hydrolase activity;protein binding;small GTPase regulator activity cell communication;cellular process;intracellular signaling cascade;lipid metabolic process;metabolic process;protein transport;regulation of ARF GTPase activity;regulation of GTPase activity;regulation of Ras GTPase activity;signal transduction;transport 10 10 10 18.5 18.5 18.5 81.535 1.0978E-159 328680000 163190000 165480000 1171 IPI:IPI00014199.1 ARFGAP with coiled-coil, ANK repeat and PH domain-containing protein 1;Centaurin-beta-1 ACAP1;CENTB1;KIAA0050 Q15027 ENST00000158762 1 0.99771 1.8753 1.0236 1.2937 1.238 1.3481 Anticodon_1;tRNA-synt_1;tRNA-synt_1g cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;leucine-tRNA ligase activity;ligase activity;ligase activity, forming carbon-oxygen bonds;nucleoside binding;nucleotide binding;purine nucleoside binding cellular amino acid and derivative metabolic process;leucyl-tRNA aminoacylation;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;tRNA aminoacylation for protein translation;tRNA metabolic process Aminoacyl-tRNA biosynthesis;Valine, leucine and isoleucine biosynthesis 16 16 16 19.4 19.4 19.4 101.97 7.5008E-135 251970000 132690000 119280000 1172 IPI:IPI00014213.1 Probable leucyl-tRNA synthetase, mitochondrial;Leucine--tRNA ligase LARS2;KIAA0028 Q15031 ENST00000265537 K01869 1 0.67752 1.2428 0.71185 0.9151 0.82179 0.8828 FERM_M;PX cell part;cytoplasmic part;early endosome;endosome;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;organelle binding;lipid binding;lipoprotein receptor binding;low-density lipoprotein receptor binding;phosphoinositide binding;phospholipid binding;protein binding;protein C-terminus binding;receptor binding alcohol metabolic process;cell communication;cholesterol catabolic process;intracellular protein transport;lipid metabolic process;metabolic process;signal transduction;steroid catabolic process;steroid metabolic process;transport 11 11 11 24.7 24.7 24.7 52.901 7.8946E-151 165140000 90289000 74852000 1173 IPI:IPI00014219.1 Sorting nexin-17 SNX17;KIAA0064 Q15036 ENST00000233575 1 0.57799 1.0662 0.62502 0.75293 0.76644 0.78744 6 6 6 12 12 12 71.682 3.843E-70 28368000 14372000 13996000 1174 IPI:IPI00014220.2;IPI:IPI00440233.1 HAUS augmin-like complex subunit 5 HAUS5;KIAA0841 O94927-1;O94927 ENST00000203166;ENST00000379045 2 0.67955 1.6387 0.71246 0.91156 1.0079 0.95375 MAM33 cell part;cytoplasmic part;intracellular organelle part;intracellular part;membrane;mitochondrial matrix;mitochondrial part;organelle part;plasma membrane immune response;immune system process;interspecies interaction between organisms;multi-organism process;response to stimulus 10 10 10 44.7 44.7 44.7 31.362 1.8772E-287 2086200000 1152100000 934030000 1175 IPI:IPI00014230.1 Complement component 1 Q subcomponent-binding protein, mitochondrial;Glycoprotein gC1qBP;GC1q-R protein;Hyaluronan-binding protein 1;Mitochondrial matrix protein p32;p33 C1QBP;GC1QBP;HABP1;SF2P32 Q07021 ENST00000225698 1 1.0501 1.8385 1.0548 1.3901 1.2026 1.3917 Reticulon cell part;integral to membrane;intrinsic to membrane;membrane part 3 3 3 21.7 21.7 21.7 23.362 2.0333E-27 252910000 130210000 122700000 1176 IPI:IPI00014232.1 ADP-ribosylation factor-like protein 6-interacting protein 1 ARL6IP1;ARL6IP;KIAA0069 Q15041 ENST00000304414 1 0.64099 1.4574 0.79807 0.9478 1.0079 1.1175 cell fraction;cell part;cytoplasm;intracellular part;soluble fraction binding;enzyme activator activity;enzyme binding;enzyme regulator activity;GTPase activator activity;protein binding;Rab GTPase activator activity;Rab GTPase binding;Ras GTPase activator activity;Ras GTPase binding;small GTPase regulator activity biological regulation;regulation of catalytic activity;regulation of GTPase activity;regulation of hydrolase activity;regulation of molecular function 9 9 9 13.8 13.8 13.8 110.52 2.8661E-172 56576000 31615000 24961000 1177 IPI:IPI00014235.3 Rab3 GTPase-activating protein catalytic subunit;RAB3 GTPase-activating protein 130 kDa subunit;Rab3-GAP p130 RAB3GAP1;KIAA0066;RAB3GAP Q15042-1;Q15042 ENST00000264158;ENST00000375836 1 0.75918 1.4965 0.73337 1.0062 0.98671 0.96524 tRNA_anti;tRNA-synt_2 cell fraction;cell part;cytoplasm;intracellular part;soluble fraction aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-oxygen bonds;lysine-tRNA ligase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding cellular amino acid and derivative metabolic process;lysyl-tRNA aminoacylation;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;tRNA aminoacylation for protein translation;tRNA metabolic process 32 32 31 46.1 46.1 45.1 68.047 0 4239800000 2231600000 2008200000 1179 IPI:IPI00014238.2;IPI:IPI00307092.2 Lysyl-tRNA synthetase;Lysine--tRNA ligase KARS;KIAA0070 Q15046-1;Q15046;Q15046-2 ENST00000302445;ENST00000319410 2 0.63908 1.5483 0.62883 0.82087 1.0401 0.80961 RRS1 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part cellular component biogenesis;cellular process;ribonucleoprotein complex biogenesis;ribosome biogenesis 3 3 3 13.4 13.4 13.4 41.193 3.5015E-42 122680000 68600000 54082000 1181 IPI:IPI00014253.4 Ribosome biogenesis regulatory protein homolog RRS1;KIAA0112;RRR Q15050 ENST00000320270 1 0.76017 1.3689 0.73204 1.0341 0.85872 0.98133 CH;PH;RhoGEF;SH3_1 cell part;cytoplasm;intracellular part enzyme activator activity;enzyme regulator activity;GTPase activator activity;guanyl-nucleotide exchange factor activity;Ras guanyl-nucleotide exchange factor activity;Rho guanyl-nucleotide exchange factor activity;small GTPase regulator activity apoptosis;cell communication;cell death;cellular process;intracellular signaling cascade;JNK cascade;MAPKKK cascade;protein kinase cascade;regulation of cell communication;regulation of signal transduction;response to stress;signal transduction Pancreatic cancer;Regulation of actin cytoskeleton 22 22 17 32.5 32.5 26.4 87.498 4.6048E-164 552530000 289520000 263010000 1182 IPI:IPI00014256.2;IPI:IPI00640748.3 Rho guanine nucleotide exchange factor 6;Rac/Cdc42 guanine nucleotide exchange factor 6;PAK-interacting exchange factor alpha;Alpha-Pix;COOL-2 ARHGEF6;COOL2;KIAA0006;PIXA Q15052-1;Q15052;Q15052-2 ENST00000250617 K05729 2 0.78908 1.3904 0.83462 1.0488 0.9122 1.0858 RRM_1 cell part;cytoplasmic part;cytosol;eukaryotic translation initiation factor 4F complex;intracellular part;macromolecular complex;perinuclear region of cytoplasm;protein complex binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;regulation of biosynthetic process;regulation of gene expression;regulation of translation;regulation of translational initiation;translation 7 7 2 45.2 45.2 18.5 27.385 7.4476E-219 1049900000 516390000 533550000 1183 IPI:IPI00014263.1 Eukaryotic translation initiation factor 4H;Williams-Beuren syndrome chromosomal region 1 protein EIF4H;KIAA0038;WBSCR1;WSCR1 Q15056-1;Q15056 ENST00000265753;ENST00000353999 1 1.0365 2.0524 NaN 1.3496 1.3535 NaN Ank;ArfGap;PH ARF GTPase activator activity;binding;cation binding;enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;ion binding;metal ion binding;small GTPase regulator activity;zinc ion binding biological regulation;regulation of ARF GTPase activity;regulation of catalytic activity;regulation of GTPase activity;regulation of hydrolase activity;regulation of molecular function;regulation of Ras GTPase activity 8 8 8 13.9 13.9 13.9 88.028 3.5947E-78 31726000 21396000 10330000 1184 IPI:IPI00014264.5 ARFGAP with coiled-coil, ANK repeat and PH domain-containing protein 2;Centaurin-beta-2 ACAP2;CENTB2;KIAA0041 Q15057 ENST00000326793 1 0.69576 1.2044 0.72776 0.89362 0.83077 0.92954 WD40 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle biosynthetic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription 7 7 7 17.4 17.4 17.4 55.827 2.2224E-41 225890000 113980000 111910000 1185 IPI:IPI00014298.3 Periodic tryptophan protein 1 homolog;Keratinocyte protein IEF SSP 9502 PWP1 Q13610 ENST00000258531 1 0.57182 1.2363 0.67324 0.78011 0.78599 0.85479 60KD_IMP integral to membrane;integral to mitochondrial membrane;integral to organelle membrane;intracellular part;intrinsic to membrane;intrinsic to organelle membrane;macromolecular complex;mitochondrial respiratory chain;organelle part;protein complex aerobic respiration;anatomical structure formation;cellular process;generation of precursor metabolites and energy;metabolic process;NADH dehydrogenase complex assembly;protein complex assembly;protein localization 4 4 4 8.7 8.7 8.7 55.384 3.2335E-37 80746000 44241000 36505000 1186 IPI:IPI00014301.3;IPI:IPI00395015.1;IPI:IPI00395016.1 Mitochondrial inner membrane protein OXA1L;Oxidase assembly 1-like protein;OXA1Hs;Hsa OXA1L Q15070-1;Q15070;Q15070-2;Q15070-3 ENST00000285848;ENST00000358043 3 NaN 1.7152 0.80742 NaN 1.0781 1.1057 GRAM;Myotub-related cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;hydrolase activity;inositol or phosphatidylinositol phosphatase activity;phosphoprotein phosphatase activity;protein binding;protein tyrosine phosphatase activity;protein tyrosine/serine/threonine phosphatase activity cellular biopolymer metabolic process;cellular process;dephosphorylation;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid dephosphorylation;protein metabolic process;protein modification process Aminosugars metabolism;Fructose and mannose metabolism;Riboflavin metabolism;Thiamine metabolism 2 1 1 3.9 1.9 1.9 73.38 5.7202E-21 3283300 1645500 1637700 1187 IPI:IPI00014307.4 Myotubularin-related protein 2 MTMR2;KIAA1073 Q13614 ENST00000346299 K01112 1 0.51442 0.92133 0.62299 0.66573 0.61319 0.77333 Cullin;Cullin_Nedd8 cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;enzyme binding;protein binding;ubiquitin protein ligase binding cell cycle arrest;G1/S transition of mitotic cell cycle;induction of apoptosis;induction of apoptosis by intracellular signals;metabolic process;negative regulation of cell proliferation;proteolysis;ubiquitin-dependent protein catabolic process Cell cycle;Cell cycle - yeast;TGF-beta signaling pathway;Ubiquitin mediated proteolysis;Wnt signaling pathway 13 13 13 17.8 17.8 17.8 89.677 1.7668E-79 64536000 36121000 28414000 1188 IPI:IPI00014310.3 Cullin-1 CUL1 Q13616 ENST00000325222;ENST00000409469 K03347 1 0.59126 1.2789 0.56939 0.77561 0.80454 0.73504 Cullin;Cullin_Nedd8 cell part;cullin-RING ubiquitin ligase complex;intracellular part;macromolecular complex;protein complex;ubiquitin ligase complex binding;enzyme binding;protein binding;ubiquitin protein ligase binding cell cycle arrest;G1/S transition of mitotic cell cycle;induction of apoptosis;induction of apoptosis by intracellular signals;metabolic process;negative regulation of cell proliferation;proteolysis;ubiquitin-dependent protein catabolic process Pathways in cancer;Renal cell carcinoma;Ubiquitin mediated proteolysis 15 15 15 22.8 22.8 22.8 89.503 2.8663E-174 209040000 115250000 93788000 1189 IPI:IPI00014311.5 Cullin-2 CUL2 Q13617 ENST00000374748;ENST00000374749;ENST00000374751 K03870 1 0.57666 0.99464 0.54495 0.75124 0.67041 0.70866 Cullin;Cullin_Nedd8 cullin-RING ubiquitin ligase complex;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;protein complex;ubiquitin ligase complex binding;enzyme binding;protein binding;ubiquitin protein ligase binding cell cycle arrest;cyclin catabolic process;G1/S transition of mitotic cell cycle;induction of apoptosis;metabolic process;positive regulation of cell proliferation;proteolysis;ubiquitin-dependent protein catabolic process Ubiquitin mediated proteolysis 18 18 18 25.7 25.7 25.7 88.929 2.5382E-212 378070000 210760000 167310000 1190 IPI:IPI00014312.1;IPI:IPI00382458.1;IPI:IPI00382459.1 Cullin-3 CUL3;KIAA0617 Q13618-1;Q13618;Q13618-2;Q13618-3 ENST00000264414;ENST00000344951 K03869 3 0.56883 1.0404 0.59439 0.71514 0.70724 0.74983 BACK;BTB;Kelch_1 cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;organelle;protein complex;ribonucleoprotein complex;spliceosomal complex;transcription factor complex binding;protein binding metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA processing;RNA splicing;transcription;transcription from RNA polymerase III promoter;transcription, DNA-dependent 8 8 8 18.2 18.2 18.2 71.729 3.2727E-105 74782000 42250000 32533000 1191 IPI:IPI00014319.5 Influenza virus NS1A-binding protein;Aryl hydrocarbon receptor-associated protein 3 IVNS1ABP;ARA3;FLARA3;KIAA0850;NS1;NS1BP;HSPC068 Q9Y6Y0 ENST00000367498 1 0.62369 NaN 0.88278 0.91332 NaN 1.2168 Ank cell part;cytoplasm;intracellular part 2 2 2 3.2 3.2 3.2 84.88 4.9858E-22 36118000 20085000 16033000 1192 IPI:IPI00014340.2;IPI:IPI00879023.1;IPI:IPI00879187.1;IPI:IPI00443045.4 Protein phosphatase 1 regulatory subunit 12C;Protein phosphatase 1 myosin-binding subunit of 85 kDa;Protein phosphatase 1 myosin-binding subunit p85 PPP1R12C;LENG3;MBS85 Q9BZL4-1;Q9BZL4;Q9BZL4-4;Q9BZL4-3;Q9BZL4-2 ENST00000263433 4 0.97591 1.8888 0.95669 1.225 1.2379 1.4029 Pkinase cell part;intracellular organelle part;intracellular part;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part binding;catalytic activity;non-membrane spanning protein tyrosine kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;protein tyrosine kinase activity;purine nucleoside binding cellular process;metabolic process;nervous system development;peptidyl-tyrosine phosphorylation;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein modification process 4 4 4 8.3 8.3 8.3 85.583 6.8257E-105 32027000 26304000 5723200 1193 IPI:IPI00014344.1;IPI:IPI00219250.1;IPI:IPI00219252.1;IPI:IPI00941492.1;IPI:IPI00219251.1;IPI:IPI00000352.1;IPI:IPI00215873.1;IPI:IPI00332215.1 Dual specificity tyrosine-phosphorylation-regulated kinase 1A;Protein kinase minibrain homolog;HP86;Dual specificity YAK1-related kinase DYRK1A;DYRK;MNB;MNBH Q13627-1;Q13627;Q13627-2;Q13627-5;Q13627-4;Q13627-3 ENST00000321219;ENST00000339659;ENST00000398956;ENST00000398960 K08825 8 0.79423 1.4561 0.77093 1.0002 1.0187 0.96889 Epimerase cell part;cytoplasm;intracellular part binding;catalytic activity;electron carrier activity;isomerase activity;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor alcohol metabolic process;carbohydrate metabolic process;fucose metabolic process;L-fucose biosynthetic process;monosaccharide metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Fructose and mannose metabolism 9 9 9 36.4 36.4 36.4 35.892 1.8698E-122 372560000 198780000 173780000 1194 IPI:IPI00014361.1 GDP-L-fucose synthetase;Protein FX;Red cell NADP(H)-binding protein;GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase TSTA3 Q13630 ENST00000360125 K02377 1 0.73422 1.3571 0.71705 0.97093 0.91195 0.88114 Bromodomain cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle catalytic activity;kinase activity;phosphotransferase activity, alcohol group as acceptor;protein kinase activity;protein serine/threonine kinase activity;transferase activity;transferase activity, transferring phosphorus-containing groups gamete generation;male gamete generation;reproductive process;spermatogenesis 10 7 7 11.8 9.2 9.2 92.032 1.199E-49 165850000 88287000 77561000 1195 IPI:IPI00440502.3;IPI:IPI00014414.2 Bromodomain-containing protein 2;Protein RING3;O27.1.1 BRD2;KIAA9001;RING3 P25440-2;P25440;P25440-1 ENST00000308627;ENST00000374825;ENST00000374831;ENST00000383108;ENST00000395289;ENST00000399315;ENST00000399527;ENST00000399528;ENST00000399529 K08871 2 0.64912 1.503 NaN 0.94306 0.94258 NaN GTP_EFTU;GTP_EFTU_D2;GTP_EFTU_D3 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;nucleic acid binding;nucleotide binding;protein binding;pyrophosphatase activity;translation elongation factor activity;translation factor activity, nucleic acid binding 16 1 1 34.8 2.8 2.8 50.47 0 6365700 3703400 2662300 1196 IPI:IPI00014424.1 Elongation factor 1-alpha 2;eEF1A-2;Statin S1 EEF1A2;EEF1AL;STN Q05639 ENST00000217182;ENST00000298049 K03231 1 0.74221 1.5814 0.89504 0.99652 1.0091 1.1733 centrosome;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;microtubule organizing center;non-membrane-bounded organelle;nucleus;organelle;organelle part 3 3 3 33.6 33.6 33.6 13.596 7.9427E-54 63590000 33734000 29856000 1197 IPI:IPI00014437.4 Sjoegren syndrome nuclear autoantigen 1;Nuclear autoantigen of 14 kDa SSNA1;NA14 O43805 ENST00000322310 1 0.85841 1.9323 0.92554 1.1623 1.3291 1.2487 adh_short cell part;cytoplasm;intracellular part 6,7-dihydropteridine reductase activity;binding;catalytic activity;electron carrier activity;oxidoreductase activity;oxidoreductase activity, acting on the CH-NH group of donors cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;cellular aromatic compound metabolic process;L-phenylalanine catabolic process;L-phenylalanine metabolic process;organic acid metabolic process Folate biosynthesis 11 11 11 63.9 63.9 63.9 25.789 1.2914E-161 185840000 100850000 84989000 1198 IPI:IPI00014439.4 Dihydropteridine reductase;HDHPR;Quinoid dihydropteridine reductase QDPR;DHPR P09417 ENST00000281243 K00357 1 0.88989 1.6583 0.92543 1.164 1.1374 1.18 Striatin;WD40 cell part;cytoplasm;intracellular part;membrane binding;calmodulin binding;protein binding 7 7 7 12.1 12.1 12.1 86.131 1.6792E-131 58779000 30034000 28745000 1199 IPI:IPI00014456.4;IPI:IPI00654594.3 Striatin STRN O43815-1;O43815;O43815-2 ENST00000263918;ENST00000379213 2 0.53545 1.2045 NaN 0.67378 0.88067 NaN SCO1-SenC cell part;cytoplasmic part;intracellular organelle part;intracellular part;membrane;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part binding;cation binding;copper ion binding;ion binding;metal ion binding;transition metal ion binding cation transport;cellular copper ion homeostasis;cellular ion homeostasis;cellular process;copper ion transport;ion transport;metabolic process;protein complex assembly;respiratory chain complex IV assembly;transition metal ion transport;transport 2 2 2 12.4 12.4 12.4 29.81 2.8462E-25 16542000 8704800 7836800 1200 IPI:IPI00014458.1 Protein SCO2 homolog, mitochondrial SCO2 O43819 ENST00000252785;ENST00000395693 K07152 1 0.73856 1.5424 0.70258 0.97858 1.0124 0.93282 AKAP95;RII_binding_1 cell part;intracellular organelle part;intracellular part;nuclear matrix;nuclear part;organelle part binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding biological regulation;cell communication;cellular process;regulation of biological process;regulation of cellular process;signal transduction 6 6 6 10.4 10.4 10.4 76.107 7.8487E-13 99105000 57603000 41502000 1202 IPI:IPI00014474.1 A-kinase anchor protein 8;A-kinase anchor protein 95 kDa AKAP8;AKAP95 O43823 ENST00000269701 1 0.79859 1.2812 0.72466 1.0483 0.87179 0.95758 WD40 cell part;cell surface;cytoplasm;intracellular part;membrane;plasma membrane binding;carbohydrate binding;glycosaminoglycan binding;heparin binding;pattern binding;polysaccharide binding anatomical structure formation;angiogenesis;cell differentiation;cell migration;cell motion;cellular process;muscle cell migration;positive regulation of endothelial cell migration;regulation of endothelial cell migration;smooth muscle cell migration 7 7 7 17.3 17.3 17.3 46.75 3.2608E-149 243200000 138270000 104930000 1203 IPI:IPI00014481.4 Angio-associated migratory cell protein AAMP Q13685 ENST00000248450 1 0.75246 1.417 0.77295 1.1979 0.907 1.0529 zf-C2H2 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane;membrane-bounded organelle;nuclear matrix;nuclear part;nucleus;organelle;organelle part;plasma membrane binding;DNA binding;nucleic acid binding;protein binding;transcription coactivator activity;transcription cofactor activity;transcription corepressor activity;transcription factor activity;transcription factor binding;zinc ion binding metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 8 8 8 16.4 16.4 16.4 44.712 1.4042E-142 61381000 31625000 29756000 1204 IPI:IPI00014513.1;IPI:IPI00419912.2;IPI:IPI00292080.2 Transcriptional repressor protein YY1;Yin and yang 1;Delta transcription factor;NF-E1;INO80 complex subunit S;Transcription factor YY2;Yin and yang 2;Zinc finger protein 631 YY1;INO80S;YY2;ZNF631 P25490;O15391 ENST00000262238;ENST00000361929 K09201 3 0.67919 1.4331 0.75585 0.90067 0.93516 1.0043 HMG_box cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;nucleoplasm;organelle;organelle part binding;DNA binding;nucleic acid binding;protein binding;RNA polymerase I transcription factor activity;transcription regulator activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase I promoter;regulation of transcription, DNA-dependent;transcription 25 25 25 31.7 31.7 31.7 89.405 2.6321E-149 1394800000 737330000 657500000 1205 IPI:IPI00014533.1;IPI:IPI00220833.1 Nucleolar transcription factor 1;Upstream-binding factor 1;Autoantigen NOR-90 UBTF;UBF;UBF1 P17480-1;P17480;P17480-2 ENST00000302904;ENST00000343638;ENST00000393606 K09273 2 0.91622 1.9234 0.95812 1.2403 1.2649 1.2288 Ras cell part;intracellular;membrane;plasma membrane binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleotide binding;pyrophosphatase activity cell communication;cellular component organization;cellular process;endocytosis;intracellular signaling cascade;membrane invagination;membrane organization;protein transport;signal transduction;small GTPase mediated signal transduction;transport 11 11 11 55.8 55.8 55.8 22.977 1.5852E-172 538220000 276090000 262130000 1207 IPI:IPI00014577.1 Ras-related protein Rab-18 RAB18 Q9NP72 ENST00000356940;ENST00000375800 K07910 1 0.87889 1.4813 0.9074 1.1118 1.0038 1.1765 Clathrin_lg_ch clathrin coat;clathrin coat of coated pit;clathrin coat of trans-Golgi network vesicle;clathrin vesicle coat;Golgi apparatus part;intracellular part;macromolecular complex;membrane coat;membrane part;organelle part;protein complex;vesicle coat binding;calcium ion binding;cation binding;ion binding;metal ion binding;protein binding;structural molecule activity cellular process;establishment of localization;establishment of localization in cell;establishment of protein localization;intracellular protein transport;intracellular transport;protein transport;transport;vesicle-mediated transport Huntington's disease 4 4 4 10.9 10.9 10.9 27.076 5.4382E-10 457680000 238590000 219090000 1208 IPI:IPI00014587.1;IPI:IPI00790571.2;IPI:IPI00216393.1 Clathrin light chain A CLTA P09496-1;P09496;P09496-3;P09496-2 ENST00000242285;ENST00000345519;ENST00000396603 K04644 3 0.8068 1.7687 0.57534 1.0694 1.1479 0.76852 Clathrin_lg_ch clathrin coat;clathrin coat of coated pit;clathrin coat of trans-Golgi network vesicle;clathrin vesicle coat;Golgi apparatus part;intracellular part;macromolecular complex;membrane coat;membrane part;organelle part;protein complex;vesicle coat binding;calcium ion binding;cation binding;ion binding;metal ion binding;protein binding;structural molecule activity cellular process;establishment of localization;establishment of localization in cell;establishment of protein localization;intracellular protein transport;intracellular transport;protein transport;transport;vesicle-mediated transport Huntington's disease 4 4 4 15.3 15.3 15.3 25.19 1.2587E-13 69998000 39737000 30261000 1209 IPI:IPI00014589.1;IPI:IPI00216472.1 Clathrin light chain B CLTB P09497-1;P09497;P09497-2 ENST00000310418;ENST00000345807 K04645 2 0.66725 1.2518 0.5907 0.88736 0.8361 0.80391 Clat_adaptor_s AP-type membrane coat adaptor complex;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;cytoplasmic vesicle membrane;Golgi apparatus;membrane;membrane-bounded vesicle;organelle membrane;transport vesicle;vesicle;vesicle membrane binding;protein binding;protein transporter activity;substrate-specific transporter activity;transporter activity cell communication;cell surface receptor linked signal transduction;enzyme linked receptor protein signaling pathway;intracellular protein transport;signal transduction;transmembrane receptor protein tyrosine kinase signaling pathway;transport 4 4 4 15.4 15.4 15.4 32.144 6.0828E-22 40738000 24424000 16314000 1210 IPI:IPI00014624.2 AP-3 complex subunit sigma-1;Adapter-related protein complex 3 sigma-1 subunit;AP-3 complex sigma-3A subunit;Sigma-adaptin 3a;Sigma-3A-adaptin;Sigma3A-adaptin;Clathrin-associated/assembly/adapter protein, small 3 AP3S1;CLAPS3 Q92572 ENST00000316788 K12399 1 0.67459 1.4415 0.74366 0.9251 1.0081 0.99198 Lipase_GDSL cell part;cytoplasm;intracellular part 1-alkyl-2-acetylglycerophosphocholine esterase activity;binding;carboxylesterase activity;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;protein binding anatomical structure development;catabolic process;developmental process;lipid catabolic process;lipid metabolic process;metabolic process;nervous system development;primary metabolic process;system development Ether lipid metabolism 11 11 11 72.3 72.3 72.3 25.734 4.2106E-95 1731700000 914090000 817650000 1211 IPI:IPI00014808.1 Platelet-activating factor acetylhydrolase IB subunit gamma;PAF acetylhydrolase 29 kDa subunit;PAF-AH subunit gamma;PAFAH subunit gamma PAFAH1B3;PAFAHG Q15102 ENST00000262890 K01062 1 0.81956 1.5162 0.73701 1.0594 1.0186 0.94139 cytoplasmic part;intracellular part;macromolecular complex;mitochondrial part;mitochondrial small ribosomal subunit;organellar small ribosomal subunit;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 2 2 2 29.9 29.9 29.9 10.741 1.6155E-73 64933000 35249000 29684000 1212 IPI:IPI00014812.1 28S ribosomal protein S21, mitochondrial;S21mt;MRP-S21 MRPS21;RPMS21;MDS016 P82921 ENST00000309092;ENST00000361380 1 NaN 1.6152 NaN NaN 1.0616 NaN K_tetra;Pentapeptide cation channel complex;cell part;ion channel complex;macromolecular complex;membrane part;plasma membrane part;potassium channel complex;protein complex;voltage-gated potassium channel complex binding;cation channel activity;cation transmembrane transporter activity;ion channel activity;potassium channel activity;protein binding;transporter activity;voltage-gated ion channel activity;voltage-gated potassium channel activity cation transport;establishment of localization;ion transport;metal ion transport;monovalent inorganic cation transport;potassium ion transport;transport 3 3 3 11.6 11.6 11.6 42.566 4.0154E-10 785580 425650 359930 1213 IPI:IPI00014825.8 BTB/POZ domain-containing protein KCTD9 KCTD9 Q7L273 ENST00000221200 1 0.89098 1.3184 0.80485 1.1155 0.88942 1.0112 BCDHK_Adom3;HATPase_c cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part catalytic activity;nucleoside binding;nucleotide binding;protein histidine kinase activity;protein kinase activity;purine nucleoside binding;pyruvate dehydrogenase (acetyl-transferring) kinase activity;two-component sensor activity alcohol metabolic process;carbohydrate metabolic process;cell communication;glucose metabolic process;monosaccharide metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process Fc epsilon RI signaling pathway;T cell receptor signaling pathway 5 5 5 15.4 15.4 15.4 49.244 2.7675E-124 23177000 12807000 10369000 1214 IPI:IPI00014831.1 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial;Pyruvate dehydrogenase kinase isoform 1 PDK1 Q15118 ENST00000282077;ENST00000392571;ENST00000410055 K12077 1 0.85484 1.4506 NaN 1.0745 1.0385 NaN BCDHK_Adom3;HATPase_c cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part catalytic activity;nucleoside binding;nucleotide binding;protein histidine kinase activity;protein kinase activity;purine nucleoside binding;pyruvate dehydrogenase (acetyl-transferring) kinase activity;two-component sensor activity alcohol metabolic process;carbohydrate metabolic process;cell communication;glucose metabolic process;monosaccharide metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process 2 2 2 5.2 5.2 5.2 46.938 1.7609E-53 26562000 14066000 12496000 1215 IPI:IPI00014849.3;IPI:IPI00003425.5 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial;Pyruvate dehydrogenase kinase isoform 3;[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial;Pyruvate dehydrogenase kinase isoform 4 PDK3;PDK4 Q15120;Q16654 ENST00000379162;ENST00000005178 K00898 2 0.94859 1.4996 1.0506 1.2608 0.87859 1.3531 DED cell part;cytoplasm;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;microtubule associated complex;organelle part;protein complex binding;carbohydrate transmembrane transporter activity;cation transmembrane transporter activity;cation:sugar symporter activity;ion transmembrane transporter activity;protein binding;sugar:hydrogen symporter activity;transporter activity anti-apoptosis;apoptosis;carbohydrate transport;cell death;cellular process;death;negative regulation of glucose transport;programmed cell death;regulation of cell death;regulation of glucose transport;regulation of localization;transport 4 4 4 44.6 44.6 44.6 15.04 1.7401E-61 86015000 43806000 42209000 1216 IPI:IPI00014850.4 Astrocytic phosphoprotein PEA-15;Phosphoprotein enriched in diabetes PEA15 Q15121 ENST00000360472;ENST00000368075;ENST00000368076 1 1.7651 1.6615 1.0487 2.3025 1.1015 1.4393 NUDE_C centrosome;condensed chromosome kinetochore;intracellular non-membrane-bounded organelle;intracellular organelle;kinetochore;macromolecular complex;microtubule;microtubule organizing center;non-membrane-bounded organelle;organelle;spindle pole centrosome binding;cytoskeletal protein binding;microtubule binding;protein binding;tubulin binding cell cycle phase;cell cycle process;cell differentiation;cellular component organization;cellular process;developmental process;microtubule organizing center organization;mitosis;nervous system development;nuclear division;organelle organization 6 6 6 20.5 20.5 20.5 38.808 5.3055E-53 11415000 5157500 6257500 1219 IPI:IPI00759601.1;IPI:IPI00014893.5;IPI:IPI00384038.3;IPI:IPI00940808.1 Nuclear distribution protein nudE homolog 1 NDE1;NUDE Q9NXR1-1;Q9NXR1;Q9NXR1-2 ENST00000342673;ENST00000396353;ENST00000396358 4 0.72948 1.4049 0.67425 0.92238 0.93008 0.86327 CH;Plectin;S10_plectin cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane;non-membrane-bounded organelle;organelle;plasma membrane actin binding;binding;cytoskeletal protein binding;protein binding;structural constituent of muscle;structural molecule activity 69 69 65 17.3 17.3 16.1 531.78 0 704760000 383140000 321620000 1220 IPI:IPI00014898.3;IPI:IPI00186711.4;IPI:IPI00398778.3;IPI:IPI00398777.3;IPI:IPI00398779.5;IPI:IPI00398775.3;IPI:IPI00420096.4;IPI:IPI00398776.3;IPI:IPI00398002.6 Plectin-1;Hemidesmosomal protein 1 PLEC1 Q15149-1;Q15149;Q15149-2;Q15149-6;Q15149-5;Q15149-4;Q15149-9;Q15149-8;Q15149-7;Q15149-3 ENST00000322810;ENST00000345136;ENST00000357316 9 1.004 2.1002 1.1324 1.3638 1.3599 1.5194 DUF837 cell part;cytoplasm;intracellular part 4 4 4 19.4 19.4 19.4 29.426 1.4228E-30 15018000 7476200 7542100 1221 IPI:IPI00014903.2;IPI:IPI00418970.2;IPI:IPI00795921.1 FGFR1 oncogene partner 2 FGFR1OP2;HSPC123 Q9NVK5-1;Q9NVK5;Q9NVK5-2;Q9NVK5-3 ENST00000229395;ENST00000327214 3 0.78022 1.2587 0.78026 1.0616 0.80105 1.0428 Pkinase cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity apoptosis;cell communication;induction of apoptosis;intracellular signaling cascade;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein kinase cascade;protein modification process;signal transduction 3 3 3 11.3 11.3 11.3 42.344 5.1616E-48 17742000 10035000 7707300 1223 IPI:IPI00014934.1 Serine/threonine-protein kinase 17B;DAP kinase-related apoptosis-inducing protein kinase 2 STK17B;DRAK2 O94768 ENST00000263955;ENST00000409228 K08804 1 0.84694 1.4944 0.87763 1.1096 1.0082 1.1808 SAP cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;protein binding biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;regulation of translation;transcription 14 14 14 51 51 51 23.671 2.5575E-218 2844800000 1479400000 1365400000 1224 IPI:IPI00014938.3 SAP domain-containing ribonucleoprotein;Nuclear protein Hcc-1;Proliferation-associated cytokine-inducible protein CIP29;Cytokine-induced protein of 29 kDa SARNP;HCC1;HSPC316 P82979 ENST00000336133 1 0.8549 1.6312 0.91958 1.1933 1.0456 1.0983 B56 chromosome, centromeric region;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;nucleus;organelle;protein phosphatase type 2A complex;protein serine/threonine phosphatase complex binding;enzyme regulator activity;phosphatase regulator activity;protein binding;protein phosphatase regulator activity;protein phosphatase type 2A regulator activity biological regulation;cell communication;cellular process;regulation of biological process;regulation of cellular process;signal transduction Wnt signaling pathway 6 5 5 15.6 13.8 13.8 56.193 5.3333E-43 31782000 16403000 15379000 1225 IPI:IPI00014978.3 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform;PP2A, B subunit, B' alpha isoform;PP2A, B subunit, B56 alpha isoform;PP2A, B subunit, PR61 alpha isoform;PP2A, B subunit, R5 alpha isoform PPP2R5A Q15172 ENST00000261461 K11584 1 0.91671 1.8849 0.86885 1.1571 1.2865 1.1619 ABC_membrane;ABC_tran cell fraction;cell part;insoluble fraction;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane fraction;membrane part;plasma membrane part ATP binding;binding;catalytic activity;nucleoside binding;nucleotide binding;P-P-bond-hydrolysis-driven transmembrane transporter activity;primary active transmembrane transporter activity;purine nucleoside binding;transporter activity establishment of localization;response to chemical stimulus;response to drug;response to stimulus;transport 20 20 19 15.9 15.9 15.3 172.61 1.4838E-142 110510000 59395000 51118000 1226 IPI:IPI00719178.1;IPI:IPI00014985.1;IPI:IPI00216262.1;IPI:IPI00008338.1;IPI:IPI00216263.1;IPI:IPI00216264.1;IPI:IPI00216266.1;IPI:IPI00216265.1;IPI:IPI00216267.1 Multidrug resistance-associated protein 1;ATP-binding cassette sub-family C member 1;Leukotriene C(4) transporter ABCC1;MRP;MRP1 P33527-9;P33527;P33527-1;P33527-3;P33527-2;P33527-4;P33527-5;P33527-7;P33527-6;P33527-8 ENST00000345148;ENST00000346370;ENST00000349029;ENST00000351154;ENST00000399408;ENST00000399410 9 0.71339 1.4846 0.72055 0.94773 0.91749 0.94462 Pyrophosphatase cell part;cytoplasmic part;cytosol;intracellular part binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;inorganic diphosphatase activity;magnesium ion binding;pyrophosphatase activity cellular metabolic process;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process Oxidative phosphorylation 21 21 21 72 72 72 32.66 0 3813600000 2033600000 1780000000 1227 IPI:IPI00015018.1 Inorganic pyrophosphatase;Pyrophosphate phospho-hydrolase PPA1;IOPPP;PP Q15181 ENST00000373232 K01507 1 0.86043 1.7069 0.86491 1.1426 1.0988 1.1489 CS cell part;chromosomal part;chromosome, telomeric region;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;telomerase holoenzyme complex binding;catalytic activity;isomerase activity;nucleotidyltransferase activity;protein binding;RNA-directed DNA polymerase activity;telomerase activity;transferase activity;transferase activity, transferring phosphorus-containing groups DNA metabolic process;fatty acid metabolic process;lipid metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;prostaglandin biosynthetic process;telomere maintenance 6 6 6 36.9 36.9 36.9 18.697 1.7023E-191 3462500000 1785800000 1676700000 1228 IPI:IPI00015029.1 Prostaglandin E synthase 3;Cytosolic prostaglandin E2 synthase;Telomerase-binding protein p23;Progesterone receptor complex p23 PTGES3;P23;TEBP Q15185 ENST00000262033 1 0.8652 1.6225 0.81237 1.1274 1.0501 1.059 SUI1 cell part;cytoplasm;intracellular part binding;nucleic acid binding;protein binding;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity cellular process;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of translation;regulation of translational initiation;response to stress;translational initiation 6 6 6 79.6 79.6 79.6 12.732 0 1561700000 788550000 773170000 1229 IPI:IPI00015077.1;IPI:IPI00031489.1 Eukaryotic translation initiation factor 1;Protein translation factor SUI1 homolog;Sui1iso1;A121;Eukaryotic translation initiation factor 1b;Protein translation factor SUI1 homolog GC20 EIF1;SUI1;EIF1B P41567;O60739 ENST00000310837;ENST00000232905 2 0.76204 1.2643 0.82834 0.96525 0.88782 1.0482 CKS cyclin-dependent protein kinase regulator activity;enzyme regulator activity;kinase regulator activity;protein kinase regulator activity cell communication;cytoskeleton organization;microtubule cytoskeleton organization;microtubule-based process;organelle organization;regulation of cyclin-dependent protein kinase activity;signal transduction;spindle organization 3 3 3 25.3 25.3 25.3 9.8602 3.5197E-10 412520000 95330000 317190000 1231 IPI:IPI00015105.1 Cyclin-dependent kinases regulatory subunit 2 CKS2 P33552 ENST00000314355 1 0.73533 1.2508 NaN 0.99381 0.82027 NaN CH;GAS2 actin filament;cell part;cytoplasm;cytoskeletal part;intracellular organelle part;intracellular part;membrane;organelle part apoptosis;cell cycle arrest;cell cycle process;cell death;cellular process;death;programmed cell death;regulation of anatomical structure morphogenesis;regulation of biological process;regulation of cell morphogenesis;regulation of cell shape 6 6 6 21.4 21.4 21.4 34.945 2.8718E-87 12902000 6935000 5966600 1232 IPI:IPI00015130.1 Growth arrest-specific protein 2 GAS2 O43903 ENST00000278187 1 0.51949 1.1553 0.52061 0.69565 0.74478 0.69654 cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part adenyl nucleotide binding;ATP binding;binding;DNA binding;DNA replication origin binding;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;ribonucleotide binding cellular biopolymer metabolic process;cellular process;DNA metabolic process;DNA replication initiation;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Cell cycle;Cell cycle - yeast 4 4 4 9.7 9.7 9.7 50.282 1.6006E-59 48118000 25539000 22579000 1233 IPI:IPI00015143.1 Origin recognition complex subunit 5 ORC5L O43913 ENST00000297431 K02607 1 0.76413 1.6906 0.81566 1.0608 1.0822 1.0605 Ras cell part;cytoplasmic part;cytosol;intracellular part;membrane;plasma membrane binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding biological regulation;cell communication;cellular process;intracellular signaling cascade;regulation of biological process;regulation of cellular process;signal transduction;small GTPase mediated signal transduction Chemokine signaling pathway;Focal adhesion;Leukocyte transendothelial migration;Long-term potentiation;MAPK signaling pathway;Renal cell carcinoma 9 9 3 40.8 40.8 19 20.825 2.5861E-163 1283800000 686300000 597450000 1234 IPI:IPI00015148.3;IPI:IPI00412525.1 Ras-related protein Rap-1b;GTP-binding protein smg p21B;Ras-related protein Rap-1b-like protein RAP1B;OK/SW-cl.11 P61224;A6NIZ1 ENST00000250559;ENST00000393436;ENST00000338626 K07836 2 0.74381 1.2265 0.77644 0.91698 0.83941 0.94878 GMP_PDE_delta 3',5'-cyclic-nucleotide phosphodiesterase activity;binding;catalytic activity;cyclic-nucleotide phosphodiesterase activity;hydrolase activity;hydrolase activity, acting on ester bonds;phosphoric diester hydrolase activity;protein binding cognition;multicellular organismal process;neurological system process;response to stimulus;sensory perception;sensory perception of light stimulus;system process;visual perception Progesterone-mediated oocyte maturation;Purine metabolism 4 4 4 32 32 32 17.42 1.0274E-17 500890000 264190000 236700000 1235 IPI:IPI00015161.1 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta;Protein p17 PDE6D;PDED O43924 ENST00000287600 K01120 1 0.68988 1.5864 0.50674 0.95763 0.98273 0.7043 cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part ATP binding;binding;catalytic activity;DNA binding;DNA replication origin binding;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity cellular biopolymer metabolic process;cellular process;DNA metabolic process;DNA replication initiation;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Cell cycle;Cell cycle - yeast + 10 10 10 26.6 26.6 26.6 50.377 1.418E-62 46619000 25563000 21057000 1236 IPI:IPI00015164.4;IPI:CON_00688419.1 Origin recognition complex subunit 4 ORC4L O43929;Q2YDI2 ENST00000264169;ENST00000392857;ENST00000392858 K02606 2 0.82969 NaN 0.058513 1.1206 NaN 0.079604 Arf cell fraction;cell part;cytoplasmic part;Golgi apparatus;insoluble fraction;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane fraction;membrane-bounded organelle;organelle binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleotide binding;pyrophosphatase activity biological regulation;cell communication;cellular process;intracellular signaling cascade;regulation of biological process;regulation of cellular process;signal transduction;small GTPase mediated signal transduction 2 2 2 11.4 11.4 11.4 22.614 2.1204E-18 8686300 7820600 865750 1237 IPI:IPI00015178.1 ADP-ribosylation factor-related protein 1 ARFRP1;ARP1 Q13795 ENST00000324228;ENST00000359715 1 0.64597 1.3151 0.56392 0.86238 0.85596 0.79833 Suf cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;protein binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 14 14 14 23 23 23 82.921 4.9196E-159 157200000 85034000 72168000 1238 IPI:IPI00015195.1 Cleavage stimulation factor 77 kDa subunit;CF-1 77 kDa subunit CSTF3 Q12996 ENST00000323959 1 0.91062 1.7671 1.0003 1.202 1.1776 1.2174 V-set cell fraction;cell part;insoluble fraction;integral to membrane;intrinsic to membrane;membrane;membrane fraction;membrane part;plasma membrane molecular transducer activity;receptor activity;signal transducer activity cell activation;cell communication;cell surface receptor linked signal transduction;enzyme linked receptor protein signaling pathway;immune response;immune system process;signal transduction;transmembrane receptor protein tyrosine kinase signaling pathway Hematopoietic cell lineage 3 3 3 20.4 20.4 20.4 25.409 4.2605E-23 126320000 62661000 63660000 1239 IPI:IPI00015199.1 T-cell antigen CD7;GP40;T-cell leukemia antigen;TP41;Leu-9 CD7 P09564 ENST00000312648 K06457 1 1.1035 1.9532 1.087 1.5252 1.2564 1.4708 Calponin;CH cell junction;cell part;cell-cell junction;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane part;non-membrane-bounded organelle;organelle;plasma membrane part actin binding;binding;calmodulin binding;cytoskeletal protein binding;protein binding actin cytoskeleton organization;actin filament-based process;actomyosin structure organization;cellular component organization;cellular process;cytoskeleton organization;organelle organization 12 12 11 46 46 42.4 33.697 0 694350000 342120000 352240000 1240 IPI:IPI00015262.10 Calponin-2;Calponin H2, smooth muscle;Neutral calponin CNN2 Q99439 ENST00000263097 1 0.67095 1.3168 0.69683 0.84411 0.92314 0.88811 CTP_transf_2 catalytic activity;cytidylyltransferase activity;ethanolamine-phosphate cytidylyltransferase activity;nucleotidyltransferase activity;transferase activity;transferase activity, transferring phosphorus-containing groups biosynthetic process;cellular metabolic process;cellular process;lipid biosynthetic process;lipid metabolic process;metabolic process;organophosphate metabolic process;phospholipid biosynthetic process;phospholipid metabolic process Aminophosphonate metabolism;Glycerophospholipid metabolism 8 8 8 24.2 24.2 24.2 43.835 5.9152E-66 111730000 60225000 51501000 1241 IPI:IPI00015285.7 Ethanolamine-phosphate cytidylyltransferase;Phosphorylethanolamine transferase;CTP:phosphoethanolamine cytidylyltransferase PCYT2 Q99447 ENST00000331285 K00967 1 0.99404 NaN NaN 1.2442 NaN NaN IRS;PH binding;insulin receptor binding;protein binding;protein complex binding;receptor binding cell communication;cell surface receptor linked signal transduction;cellular process;enzyme linked receptor protein signaling pathway;regulation of biological process;signal transduction;transmembrane receptor protein tyrosine kinase signaling pathway 2 2 2 6.2 6.2 6.2 52.391 1.5144E-10 2990600 1946500 1044100 1242 IPI:IPI00015287.1;IPI:IPI00917613.1;IPI:IPI00218542.1 Docking protein 1;Downstream of tyrosine kinase 1;p62(dok);pp62 DOK1 Q99704-1;Q99704;Q99704-3;Q99704-2 ENST00000233668;ENST00000340004 3 0.76713 1.54 0.77814 1.0073 0.99208 1.0212 DUF1000 8 8 8 35.1 35.1 35.1 24.178 6.0589E-227 207550000 108840000 98710000 1243 IPI:IPI00015351.2;IPI:IPI00643524.2 UPF0424 protein C1orf128 C1orf128;AD039;HT014;PP603 Q9GZP4-1;Q9GZP4;Q9GZP4-2 ENST00000246151 2 0.76442 1.6437 0.76505 1.0364 1.0367 1.0101 Prefoldin cytoskeleton;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle;prefoldin complex;protein complex binding;protein binding;transcription cofactor activity;transcription corepressor activity;transcription factor binding;transcription regulator activity;transcription repressor activity;unfolded protein binding cellular process;metabolic process;protein folding;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of transcription, DNA-dependent 11 11 11 81.2 81.2 81.2 17.328 0 1035100000 564160000 470960000 1244 IPI:IPI00015361.1 Prefoldin subunit 5;C-myc-binding protein Mm-1;Myc modulator 1 PFDN5;MM1;PFD5 Q99471 ENST00000334478 K04797 1 NaN 2.2761 NaN NaN 1.5805 NaN PAF-AH_p_II cell part;cytoplasm;intracellular part 1-alkyl-2-acetylglycerophosphocholine esterase activity;binding;carboxylesterase activity;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;lipid binding;phospholipid binding catabolic process;lipid catabolic process;lipid metabolic process;metabolic process;primary metabolic process Ether lipid metabolism 4 4 4 11.2 11.2 11.2 44.035 2.6212E-47 682390 422090 260300 1245 IPI:IPI00015388.1 Platelet-activating factor acetylhydrolase 2, cytoplasmic;Serine-dependent phospholipase A2;HSD-PLA2 PAFAH2 Q99487 ENST00000374282;ENST00000374284 K01062 1 0.79421 1.4551 0.79881 1.0144 1.0505 1.0263 Ank;ArfGap;Miro;PH cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ARF GTPase activator activity;binding;catalytic activity;enzyme activator activity;GTP binding;GTPase activator activity;GTPase activity;hydrolase activity;nucleotide binding;pyrophosphatase activity;small GTPase regulator activity;zinc ion binding cell communication;cellular process;intracellular signaling cascade;protein transport;regulation of ARF GTPase activity;regulation of GTPase activity;regulation of Ras GTPase activity;signal transduction;small GTPase mediated signal transduction;transport 6 6 1 10.9 10.9 1.6 90.536 7.7357E-156 49285000 28398000 20886000 1246 IPI:IPI00015401.1 Arf-GAP, GTPase, ANK repeat and PH domain-containing protein 2;Centaurin-gamma-1;Phosphatidylinositol-3-kinase enhancer;GTP-binding and GTPase-activating protein 2 AGAP2;CENTG1;KIAA0167 Q99490-2;Q99490 ENST00000257897;ENST00000328568 1 0.67874 1.5282 0.83502 0.9186 1.0823 1.1461 ARID cell part;chromatin remodeling complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex;SWI/SNF complex;SWI/SNF-type complex binding;DNA binding;nucleic acid binding;protein binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding;transcription regulator activity chromatin organization;chromatin remodeling;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;regulation of transcription, DNA-dependent;transcription 5 4 4 2.7 1.8 1.8 241.46 3.1663E-24 21652000 10884000 10769000 1247 IPI:IPI00396577.2;IPI:IPI00395617.5;IPI:IPI00015404.2 AT-rich interactive domain-containing protein 1B;ARID domain-containing protein 1B;Osa homolog 2;p250R;BRG1-binding protein hELD/OSA1;BRG1-associated factor 250b ARID1B;DAN15;KIAA1235;OSA2 Q8NFD5-3;Q8NFD5;Q8NFD5-2;Q8NFD5-1 ENST00000350026;ENST00000367148 K11653 3 0.81713 1.6657 1.028 1.0298 1.038 1.2994 SDF cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;integral to membrane;integral to plasma membrane;intermediate filament;intrinsic to membrane;intrinsic to plasma membrane;melanosome;membrane-bounded vesicle;organelle;vesicle amine transmembrane transporter activity;anion channel activity;chloride channel activity;dicarboxylic acid transmembrane transporter activity;ion channel activity;sulfur amino acid transmembrane transporter activity;transporter activity amino acid transport;cell communication;cell-cell signaling;cellular process;dicarboxylic acid transport;monocarboxylic acid transport;nerve-nerve synaptic transmission;sulfur amino acid transport;synaptic transmission;system process;transport 4 4 4 10.7 10.7 10.7 55.722 3.6477E-89 36129000 19546000 16583000 1248 IPI:IPI00015476.1 Neutral amino acid transporter A;Alanine/serine/cysteine/threonine transporter;ASCT1;SATT;Solute carrier family 1 member 4 SLC1A4;ASCT1;SATT P43007 ENST00000234256 1 0.44056 0.89762 0.42272 0.55139 0.60989 0.55381 WD40 cytoplasm;DNA-directed RNA polymerase II, holoenzyme;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nucleolus;organelle;protein complex;transcription elongation factor complex RNA polymerase II transcription elongation factor activity;transcription elongation regulator activity;transcription regulator activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 15 15 15 24.1 24.1 24.1 92.499 2.6706E-118 269020000 160430000 108590000 1249 IPI:IPI00015560.7;IPI:IPI00304246.2;IPI:IPI00289763.2;IPI:IPI00470701.2 Elongator complex protein 2;STAT3-interacting protein;StIP1;SHINC-2 ELP2;STATIP1 Q6IA86-1;Q6IA86;Q6IA86-3;Q6IA86-2;Q6IA86-4 ENST00000350494;ENST00000351393;ENST00000358232 K11374 4 0.6443 1.5106 0.63668 0.85334 1.0314 0.84049 BTB;Kelch_1 binding;protein binding 5 5 5 9.1 9.1 9.1 65.719 1.4992E-10 11384000 6632200 4752200 1250 IPI:IPI00015568.1 Kelch repeat and BTB domain-containing protein 11;Kelch domain-containing protein 7B KBTBD11;KIAA0711;KLHDC7C O94819 ENST00000320248 K10476 1 0.96408 1.5312 1.1545 1.2466 1.0348 1.4857 FCH;SH3_1 cell cortex;cell part;cytoplasmic part;cytoplasmic vesicle;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane;non-membrane-bounded organelle;organelle;plasma membrane;vesicle binding;lipid binding cellular component organization;cellular process;endocytosis;establishment of localization;membrane invagination;membrane organization;transport;vesicle-mediated transport 6 6 6 9.6 9.6 9.6 70.065 1.3372E-09 12212000 6137900 6074300 1251 IPI:IPI00646028.3;IPI:IPI00807364.1;IPI:IPI00028718.3;IPI:IPI00607808.2;IPI:IPI00015580.3 Formin-binding protein 1-like;Transducer of Cdc42-dependent actin assembly protein 1 FNBP1L;C1orf39;TOCA1 Q5T0N5-2;Q5T0N5;Q5T0N5-1;Q5T0N5-5;Q5T0N5-4;Q5T0N5-3 ENST00000260506;ENST00000370253;ENST00000370256 5 0.92603 1.811 0.89581 1.1835 1.1967 1.193 TPR_1;TPR_2 cytoplasmic part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;macromolecular complex;membrane part;mitochondrial outer membrane translocase complex;mitochondrial part;organelle part;protein complex binding;protein binding;protein transmembrane transporter activity;protein transporter activity;substrate-specific transmembrane transporter activity;substrate-specific transporter activity;transmembrane transporter activity;transporter activity 23 23 23 44.9 44.9 44.9 67.454 2.8245E-274 811940000 404270000 407660000 1252 IPI:IPI00015602.1 Mitochondrial import receptor subunit TOM70;Mitochondrial precursor proteins import receptor;Translocase of outer membrane 70 kDa subunit TOMM70A;KIAA0719 O94826 ENST00000284320 1 0.77646 1.2796 0.68901 0.98717 0.91285 0.84322 Tubulin;Tubulin_C cell part;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;microtubule;organelle part;protein complex binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;pyrophosphatase activity;structural molecule activity anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;microtubule-based movement;microtubule-based process;protein complex assembly Gap junction 5 1 1 9.6 3.8 3.8 49.908 3.5679E-104 7190200 3756700 3433500 1253 IPI:IPI00015671.3;IPI:IPI00879904.1 Tubulin alpha chain-like 3 TUBAL3 A6NHL2-1;A6NHL2;A6NHL2-2 ENST00000380419 K07374 2 NaN 0.95687 0.64848 NaN 0.68294 0.86111 Radical_SAM;TRAM;UPF0004 cell part;integral to membrane;intrinsic to membrane;membrane part 4 iron, 4 sulfur cluster binding;binding;catalytic activity;cation binding;ion binding;iron ion binding;iron-sulfur cluster binding;metal cluster binding;metal ion binding;transition metal ion binding metabolic process 5 5 5 13.8 13.8 13.8 65.111 4.1336E-125 24598000 18135000 6463000 1254 IPI:IPI00015713.4;IPI:IPI00443485.2 CDK5 regulatory subunit-associated protein 1-like 1 CDKAL1 Q5VV42-1;Q5VV42;Q5VV42-2 ENST00000274695;ENST00000378610;ENST00000378624;ENST00000397216 2 0.78402 1.6227 0.82281 1.0684 1.0258 1.0928 ThiF cell part;cytoplasm;intracellular part binding;catalytic activity catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 9 9 9 27 27 27 44.863 5.2727E-121 269680000 146840000 122850000 1255 IPI:IPI00015736.3;IPI:IPI00383579.2 Ubiquitin-like modifier-activating enzyme 5;Ubiquitin-activating enzyme E1 domain-containing protein 1;UFM1-activating enzyme;ThiFP1 UBA5;UBE1DC1 Q9GZZ9-1;Q9GZZ9;Q9GZZ9-2 ENST00000356232 K12164 2 NaN 1.059 NaN NaN 0.68861 NaN fn3;I-set;MAM;Y_phosphatase adherens junction;anchoring junction;cell junction;cell part;cell surface;cell-cell junction;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;leading edge membrane;membrane part;plasma membrane part binding;catalytic activity;phosphoprotein phosphatase activity;protein binding;protein tyrosine phosphatase activity;receptor activity;signal transducer activity;transmembrane receptor activity;transmembrane receptor protein tyrosine phosphatase activity cell motion;cell-substrate junction assembly;phosphate metabolic process;phosphorus metabolic process;protein amino acid dephosphorylation;protein modification process;response to oxidative stress;response to reactive oxygen species;response to stress 3 3 2 2.8 2.8 2.1 162.17 9.1314E-07 2219300 1290300 929030 1256 IPI:IPI00644648.2;IPI:IPI00015756.2 Receptor-type tyrosine-protein phosphatase kappa PTPRK;PTPK Q15262-2;Q15262;Q15262-1 ENST00000368210;ENST00000368213;ENST00000368226 2 0.78379 1.4841 0.76135 1.0503 0.95365 1.0094 HCaRG binding;protein binding 8 8 8 54.4 54.4 54.4 22.151 2.6319E-114 151610000 80110000 71501000 1257 IPI:IPI00015773.3 COMM domain-containing protein 3;Protein Bup;Protein PIL COMMD3;BUP;C10orf8 Q9UBI1 ENST00000376836 1 0.77145 1.3545 0.6334 1.0275 0.94534 0.80831 EST1 chromosome, telomeric region;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nucleolus;organelle;organelle part;ribonucleoprotein complex;telomerase holoenzyme complex binding;catalytic activity;cation binding;DNA binding;endonuclease activity;hydrolase activity;hydrolase activity, acting on ester bonds;ion binding;manganese ion binding;nuclease activity;nucleic acid binding;protein binding;telomeric DNA binding DNA metabolic process;nuclear-transcribed mRNA catabolic process;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA catabolic process;telomere maintenance 4 4 4 3.5 3.5 3.5 160.46 2.1327E-18 8408600 4399900 4008800 1258 IPI:IPI00015793.7;IPI:IPI00014252.1 Telomerase-binding protein EST1A;Ever shorter telomeres 1A;Telomerase subunit EST1A;EST1-like protein A;Smg-6 homolog SMG6;C17orf31;EST1A;KIAA0732 Q86US8-1;Q86US8;Q86US8-2 ENST00000263073;ENST00000354901 K11124 2 0.65445 1.4768 0.54848 0.89562 0.9331 0.74381 dsrm;Dus cell part;cytoplasmic part;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle binding;catalytic activity;double-stranded RNA binding;nucleic acid binding;nucleoside binding;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on the CH-CH group of donors;purine nucleoside binding;RNA binding cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;tRNA metabolic process;tRNA processing 7 7 7 18.3 18.3 18.3 55.05 6.5949E-115 43260000 24611000 18649000 1259 IPI:IPI00015804.1 tRNA-dihydrouridine synthase 2-like;Up-regulated in lung cancer;URLC8 DUS2L;DUS2 Q9NX74 ENST00000358896 K05543 1 0.64883 1.3312 0.72936 0.8296 0.86312 0.95567 TPR_1;TPR_2 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex;transcription factor TFIIIC complex binding;DNA binding;nucleic acid binding biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription;transcription from RNA polymerase III promoter;transcription, DNA-dependent 10 10 10 12.4 12.4 12.4 101.27 5.0075E-88 140760000 77855000 62904000 1260 IPI:IPI00015806.3;IPI:IPI00411594.1 General transcription factor 3C polypeptide 3;Transcription factor IIIC subunit gamma;TFIIIC 102 kDa subunit GTF3C3 Q9Y5Q9-1;Q9Y5Q9;Q9Y5Q9-2 ENST00000263956 2 0.59202 1.1183 0.54958 0.749 0.75465 0.75439 MMR_HSR1;NGP1NT cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity cellular component biogenesis;cellular process;ribonucleoprotein complex biogenesis;ribosome biogenesis 13 13 13 15.7 15.7 15.7 83.654 3.3706E-81 149850000 83003000 66850000 1261 IPI:IPI00015808.3 Nucleolar GTP-binding protein 2;Autoantigen NGP-1 GNL2;NGP1 Q13823 ENST00000373062 1 0.85896 1.5595 0.79513 1.1194 1.0765 0.97589 Peptidase_M22 binding;catalytic activity;cation binding;endopeptidase activity;hydrolase activity;ion binding;metal ion binding;metalloendopeptidase activity;metallopeptidase activity;peptidase activity;protein binding;transition metal ion binding;zinc ion binding biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis 11 11 11 43.6 43.6 43.6 36.426 1.0446E-147 268170000 142720000 125450000 1262 IPI:IPI00015809.1 Probable O-sialoglycoprotein endopeptidase OSGEP;GCPL1 Q9NPF4 ENST00000206542 K01409 1 0.61261 1.1807 0.6822 0.78977 0.77436 0.86579 ABC_membrane;ABC_tran ATP-binding cassette (ABC) transporter complex;integral to membrane;intrinsic to membrane;macromolecular complex;membrane;mitochondrial inner membrane;mitochondrial membrane;organelle inner membrane;organelle membrane;organelle part;protein complex ATP binding;binding;catalytic activity;nucleoside binding;nucleotide binding;P-P-bond-hydrolysis-driven transmembrane transporter activity;primary active transmembrane transporter activity;purine nucleoside binding;transporter activity establishment of localization;transport ABC transporters 13 13 13 17.9 17.9 17.9 79.147 7.5368E-154 140470000 74941000 65528000 1263 IPI:IPI00015826.2 ATP-binding cassette sub-family B member 10, mitochondrial;ATP-binding cassette transporter 10;Mitochondrial ATP-binding cassette 2 ABCB10 Q9NRK6 ENST00000344517 K05657 1 0.86897 1.7949 0.91256 1.1493 1.1325 1.2524 CHCH;DUF737 binding;protein binding 10 10 10 44.5 44.5 44.5 26.152 7.7859E-200 1037300000 527840000 509490000 1264 IPI:IPI00015833.1 Coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrial CHCHD3 Q9NX63 ENST00000262570 1 0.85825 1.5983 0.8983 1.0901 1.1136 1.2492 PH;PID cell fraction;cytosol;early endosome membrane;endosome membrane;insoluble fraction;intracellular organelle;membrane;membrane fraction;membrane-bounded organelle;microsome;nucleus;organelle;organelle membrane;vesicle membrane;vesicular fraction binding;enzyme binding;kinase binding;protein binding;protein kinase B binding;protein kinase binding cell communication;cell cycle;cell proliferation;cell surface receptor linked signal transduction;enzyme linked receptor protein signaling pathway;signal transduction;transmembrane receptor protein tyrosine kinase signaling pathway Colorectal cancer;Pathways in cancer 11 11 11 19 19 19 79.663 8.6732E-64 171340000 91116000 80222000 1265 IPI:IPI00015836.1 DCC-interacting protein 13-alpha;Adapter protein containing PH domain, PTB domain and leucine zipper motif 1 APPL1;APPL;DIP13A;KIAA1428 Q9UKG1 ENST00000288266 K08733 1 0.56932 1.4013 0.59479 0.83904 0.86929 0.81568 zf-LYAR cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding 19 19 19 49.9 49.9 49.9 43.614 0 548100000 310920000 237180000 1266 IPI:IPI00015838.3 Cell growth-regulating nucleolar protein LYAR;PNAS-5 Q9NX58 ENST00000343470 1 0.88214 1.8532 0.87904 1.1794 1.19 1.1769 efhand endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;membrane-enclosed lumen;organelle;organelle lumen;organelle part binding;calcium ion binding;cation binding;ion binding;metal ion binding 7 7 7 19.9 19.9 19.9 38.89 1.135E-87 156720000 82590000 74133000 1267 IPI:IPI00015842.1 Reticulocalbin-1 RCN1;RCN Q15293 ENST00000054950 1 0.74144 1.4586 0.67365 0.96175 1.0168 0.87942 Peptidase_M18 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle;vacuole aminopeptidase activity;binding;catalytic activity;cation binding;exopeptidase activity;hydrolase activity;ion binding;metal ion binding;metallopeptidase activity;peptidase activity;protein binding;transition metal ion binding;zinc ion binding biopolymer metabolic process;catabolic process;cellular process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;peptide metabolic process;protein catabolic process;protein metabolic process;proteolysis 15 15 15 44.2 44.2 44.2 54.493 9.3996E-250 307560000 164200000 143370000 1268 IPI:IPI00015856.5 Aspartyl aminopeptidase DNPEP;ASPEP;DAP Q9ULA0 ENST00000273075 1 0.57633 NaN NaN 0.79738 NaN NaN Ank;Ribonuc_2-5A cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle ATP binding;binding;catalytic activity;endonuclease activity;endoribonuclease activity;nuclease activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein kinase activity;purine nucleoside binding;ribonuclease activity;RNA binding mRNA processing;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;RNA processing 3 2 2 4.5 3.5 3.5 83.532 7.7552E-07 1940300 1070000 870380 1269 IPI:IPI00015864.1 2-5A-dependent ribonuclease;Ribonuclease L;Ribonuclease 4 RNASEL;RNS4 Q05823 ENST00000367559 K01165 1 0.6395 1.3719 0.6223 0.83108 0.93685 0.78097 ADP_ribosyl_GH cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;cation binding;hydrolase activity;hydrolase activity, acting on glycosyl bonds;hydrolase activity, hydrolyzing O-glycosyl compounds;ion binding;magnesium ion binding;metal ion binding;poly(ADP-ribose) glycohydrolase activity 4 4 4 14.6 14.6 14.6 38.946 4.9221E-87 112630000 64077000 48552000 1270 IPI:IPI00015865.6 Poly(ADP-ribose) glycohydrolase ARH3;ADP-ribosylhydrolase 3;[Protein ADP-ribosylarginine] hydrolase-like protein 2 ADPRHL2;ARH3 Q9NX46 ENST00000373178 K11687 1 0.79784 1.4345 0.81779 0.97245 0.96337 1.0419 centrosome;intracellular non-membrane-bounded organelle;intracellular organelle;membrane-enclosed lumen;microtubule organizing center;mitochondrial intermembrane space;non-membrane-bounded organelle;organelle;organelle envelope lumen;organelle part enzyme regulator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity;small GTPase regulator activity biological regulation;cell communication;cellular process;regulation of biological process;regulation of cellular process;signal transduction 2 2 2 14.7 14.7 14.7 18.822 2.4177E-86 36666000 21479000 15187000 1271 IPI:IPI00015866.2;IPI:IPI00845377.1 ADP-ribosylation factor-like protein 2-binding protein;Binder of ARF2 protein 1 ARL2BP;BART;BART1 Q9Y2Y0-1;Q9Y2Y0;Q9Y2Y0-2 ENST00000219204 2 0.6464 1.857 0.75103 0.90039 1.1247 1.0533 Prefoldin_2 cell part;cytoplasmic part;cytosolic part;intracellular part;macromolecular complex;prefoldin complex;protein complex binding;chaperone binding;protein binding;unfolded protein binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 5 5 5 29.9 29.9 29.9 15.314 4.5345E-94 272190000 174930000 97259000 1273 IPI:IPI00015891.1 Prefoldin subunit 4;Protein C-1 PFDN4;PFD4 Q9NQP4 ENST00000371419 K09550 1 1.4724 2.5008 1.3837 1.8853 1.7146 1.8442 CHORD;CS binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding 22 22 22 71.7 71.7 71.7 37.489 0 2985000000 1455500000 1529400000 1274 IPI:IPI00015897.2;IPI:IPI00885057.1 Cysteine and histidine-rich domain-containing protein 1;CHORD domain-containing protein 1 CHORDC1;CHP1 Q9UHD1-1;Q9UHD1;Q9UHD1-2 ENST00000320585 2 0.71208 1.2545 0.74172 0.87575 0.89126 0.92326 cytoplasm;exosome (RNase complex);intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;protein complex 3'-5' exonuclease activity;3'-5'-exoribonuclease activity;7S RNA binding;binding;catalytic activity;exonuclease activity;exoribonuclease activity;hydrolase activity;nuclease activity;nucleic acid binding;protein binding;ribonuclease activity;RNA binding cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 5 5 5 19.5 19.5 19.5 32.789 8.6505E-82 197420000 107380000 90043000 1275 IPI:IPI00015905.1 Exosome complex exonuclease RRP4;Ribosomal RNA-processing protein 4;Exosome component 2 EXOSC2;RRP4 Q13868 ENST00000372358 K03679 1 0.85423 1.6871 0.90994 1.1348 1.1157 1.1621 Pyr_redox;Pyr_redox_2;Pyr_redox_dim cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part binding;catalytic activity;dihydrolipoyl dehydrogenase activity;nucleoside binding;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;purine nucleoside binding biological regulation;cell redox homeostasis;cellular homeostasis;cellular process;homeostatic process;regulation of biological process;regulation of biological quality;regulation of cellular process 15 15 15 36.1 36.1 36.1 54.177 0 1538400000 786440000 751920000 1276 IPI:IPI00015911.2 Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoamide dehydrogenase;Glycine cleavage system L protein DLD;GCSL;LAD;PHE3 P09622 ENST00000205402 1 0.43548 0.85211 0.35114 0.53928 0.58024 0.46303 cytoskeleton;integrator complex;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;organelle;organelle part;protein complex binding;molecular transducer activity;protein binding;receptor activity;signal transducer activity;transmembrane receptor activity cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;snRNA metabolic process;snRNA processing 6 6 6 6.9 6.9 6.9 100.39 1.2243E-30 12309000 6782500 5527000 1279 IPI:IPI00015922.2;IPI:IPI00456694.2;IPI:IPI00738767.2 Integrator complex subunit 6;Protein deleted in cancer 1;Protein DDX26;DBI-1;Protein DDX26B INTS6;DBI1;DDX26;DDX26A;DDX26B Q9UL03-1;Q9UL03;Q5JSJ4-1;Q5JSJ4 ENST00000311234;ENST00000356856;ENST00000370752 3 0.83079 1.3757 0.72062 1.0455 0.94436 1.0514 G-patch;TFP11 cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;ossification;RNA metabolic process;RNA processing;RNA splicing 12 12 12 17.3 17.3 17.3 96.819 6.1838E-66 123580000 66899000 56678000 1281 IPI:IPI00015924.1;IPI:IPI00220893.1 Tuftelin-interacting protein 11;Septin and tuftelin-interacting protein 1 TFIP11;STIP;HSPC006 Q9UBB9-1;Q9UBB9 ENST00000263115;ENST00000405938;ENST00000407148;ENST00000407431;ENST00000407690 2 4.2789 8.7264 4.4509 5.7597 5.9203 5.8041 DnaJ;DnaJ_C cell part;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;heat shock protein binding;protein binding;unfolded protein binding response to biotic stimulus;response to chemical stimulus;response to organic substance;response to protein stimulus;response to stimulus;response to stress;response to unfolded protein 19 19 18 41.8 41.8 41.8 38.044 1.0145E-273 2494800000 675820000 1819000000 1282 IPI:IPI00015947.5 DnaJ homolog subfamily B member 1;Heat shock 40 kDa protein 1;HSP40;DnaJ protein homolog 1;HDJ-1 DNAJB1;DNAJ1;HDJ1;HSPF1 P25685 ENST00000254322 K09507 1 0.6225 1.2667 0.58404 0.82619 0.82481 0.77032 DEAD;GUCT;Helicase_C cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part ATP binding;ATP-dependent RNA helicase activity;binding;catalytic activity;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;RNA binding;RNA helicase activity 47 47 45 57.7 57.7 55.8 87.343 0 4822000000 2647800000 2174200000 1283 IPI:IPI00015953.3;IPI:IPI00477179.1 Nucleolar RNA helicase 2;Nucleolar RNA helicase II;Nucleolar RNA helicase Gu;RH II/Gu;Gu-alpha;DEAD box protein 21 DDX21 Q9NR30-1;Q9NR30;Q9NR30-2 ENST00000354185 2 0.90258 1.6731 0.88679 1.1891 1.0964 1.1901 Arf cell part;cytoplasmic part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleotide binding;pyrophosphatase activity cellular process;ER to Golgi vesicle-mediated transport;establishment of protein localization;Golgi vesicle transport;intracellular protein transport;intracellular transport;protein transport;transport;vesicle-mediated transport 12 12 10 70.7 70.7 59.6 22.367 9.2896E-235 1071000000 563250000 507720000 1284 IPI:IPI00015954.1 GTP-binding protein SAR1a;COPII-associated small GTPase SAR1A;SAR1;SARA;SARA1 Q9NR31 ENST00000373238;ENST00000373239;ENST00000373241;ENST00000373242 K07953 1 0.69521 1.2067 0.67961 0.84604 0.8822 0.82284 RNase_PH;RNase_PH_C cytoplasm;exosome (RNase complex);intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;protein complex 3'-5' exonuclease activity;3'-5'-exoribonuclease activity;binding;catalytic activity;exonuclease activity;exoribonuclease activity;hydrolase activity;nuclease activity;nucleic acid binding;protein binding;ribonuclease activity;RNA binding cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 2 2 2 11.1 11.1 11.1 25.249 1.6841E-56 164630000 91055000 73574000 1285 IPI:IPI00015955.5 Exosome complex exonuclease RRP46;Ribosomal RNA-processing protein 46;Exosome component 5;p12B;Chronic myelogenous leukemia tumor antigen 28 EXOSC5;CML28;RRP46 Q9NQT4 ENST00000221233 K01149 1 0.70669 1.3748 0.19578 0.95083 0.82552 0.27404 cytoplasmic exosome (RNase complex);exosome (RNase complex);intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nuclear exosome (RNase complex);nucleolus;organelle;protein complex 3'-5' exonuclease activity;3'-5'-exoribonuclease activity;binding;catalytic activity;exonuclease activity;exoribonuclease activity;hydrolase activity;nuclease activity;nucleic acid binding;protein binding;ribonuclease activity;RNA binding cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 5 5 5 24.7 24.7 24.7 29.572 1.1203E-70 21670000 11835000 9835200 1286 IPI:IPI00015956.3 Exosome complex exonuclease RRP40;Ribosomal RNA-processing protein 40;Exosome component 3;p10 EXOSC3;RRP40;CGI-102 Q9NQT5 ENST00000327304 K03681 1 0.74427 1.541 0.71505 1.0009 0.92371 1.0197 COX6C cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part catalytic activity;cation transmembrane transporter activity;cytochrome-c oxidase activity;heme-copper terminal oxidase activity;ion transmembrane transporter activity;monovalent inorganic cation transmembrane transporter activity;transporter activity cellular metabolic process;cellular process;generation of precursor metabolites and energy;metabolic process Alzheimer's disease;Cardiac muscle contraction;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 4 4 4 50.7 50.7 50.7 8.7813 9.5637E-18 909880000 484620000 425260000 1287 IPI:IPI00015972.1 Cytochrome c oxidase subunit 6C;Cytochrome c oxidase polypeptide VIc COX6C P09669 ENST00000297564 K02268 1 0.81616 1.5412 0.76747 1.0517 0.96197 1.0039 4_1_CTD;FA;FERM_C;FERM_M;FERM_N;SAB extracellular matrix;extracellular region part;extrinsic to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;nucleus;organelle;organelle part;plasma membrane;spectrin actin binding;binding;cytoskeletal protein binding;protein binding;structural molecule activity actin cytoskeleton organization;actin filament-based process;cellular component organization;cellular process;cortical actin cytoskeleton organization;cortical cytoskeleton organization;cytoskeleton organization;organelle organization 20 20 17 23.2 23.2 21.5 112.59 9.5615E-171 925560000 464190000 461380000 1288 IPI:IPI00015973.1;IPI:IPI00024062.2;IPI:IPI00645410.2;IPI:IPI00256095.5;IPI:IPI00646098.2 Band 4.1-like protein 2;Generally expressed protein 4.1;4.1G EPB41L2 O43491 ENST00000337057;ENST00000368128 5 0.76497 1.4228 0.7201 0.95216 0.92938 0.95343 MoCF_biosynth;MoeA_C;MoeA_N cell junction;cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane part;non-membrane-bounded organelle;organelle;plasma membrane part;postsynaptic membrane;synapse part binding;catalytic activity;cation binding;ion binding;magnesium ion binding;metal ion binding;nucleotide binding biosynthetic process;cellular aromatic compound metabolic process;cellular process;coenzyme biosynthetic process;coenzyme metabolic process;metabolic process;Mo-molybdopterin cofactor biosynthetic process;nitrogen compound metabolic process 8 8 8 12.4 12.4 12.4 83.447 7.7342E-61 154270000 83158000 71113000 1290 IPI:IPI00184477.2;IPI:IPI00016006.2 Gephyrin GPHN;GPH;KIAA1385 Q9NQX3-2;Q9NQX3;Q9NQX3-1 ENST00000305960;ENST00000315266 K03750 2 0.80915 1.7947 0.94176 1.089 1.2042 1.135 NIPSNAP cell fraction;insoluble fraction;integral to membrane;integral to plasma membrane;intracellular organelle;intrinsic to membrane;intrinsic to plasma membrane;membrane fraction;membrane-bounded organelle;mitochondrion;organelle 7 6 6 22.4 22.4 22.4 33.742 1.3089E-85 347620000 163140000 184480000 1293 IPI:IPI00016077.1 Protein NipSnap homolog 2;Glioblastoma-amplified sequence GBAS;NIPSNAP2 O75323 ENST00000322090 1 1.1053 2.2714 1.0424 1.4677 1.4939 1.386 Agenet;KH_1 cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;polysome;ribonucleoprotein complex binding;nucleic acid binding;RNA binding anatomical structure development;apoptosis;cell death;cell differentiation;cellular developmental process;cellular process;death;developmental process;muscle organ development;organ development;programmed cell death 17 17 15 34.1 34.1 31.6 69.72 7.4525E-252 832850000 401110000 431740000 1295 IPI:IPI00016249.4;IPI:IPI00554715.4;IPI:IPI00479630.4 Fragile X mental retardation syndrome-related protein 1 FXR1 P51114-1;P51114;P51114-2;P51114-3 ENST00000305586;ENST00000357559;ENST00000392637;ENST00000392639 3 0.96479 1.3285 0.86692 1.1838 0.9183 1.0556 Agenet;KH_1 cell part;cytoplasmic part;cytosolic large ribosomal subunit;cytosolic part;intracellular organelle part;intracellular part;large ribosomal subunit;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit binding;nucleic acid binding;protein binding;RNA binding 8 6 5 14 11.7 9 77.071 4.5752E-50 62307000 30944000 31362000 1296 IPI:IPI00016250.6 Fragile X mental retardation syndrome-related protein 2 FXR2;FMR1L2 P51116 ENST00000250113 1 0.55054 1.6218 0.56244 0.73369 1.105 0.75398 PALP;SKI ATP binding;binding;catalytic activity;kinase activity;lipid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;shikimate kinase activity;steroid binding;threonine synthase activity;transferase activity cellular amino acid and derivative metabolic process;cellular amino acid biosynthetic process;cellular amino acid metabolic process;metabolic process;nitrogen compound metabolic process;organic acid metabolic process;threonine metabolic process 8 8 8 14.1 14.1 14.1 83.069 1.4213E-74 56424000 30117000 26308000 1297 IPI:IPI00016287.5 Threonine synthase-like 1 THNSL1 Q8IYQ7 ENST00000376356 1 0.97771 1.7193 0.96748 1.2499 1.196 1.2117 Ras cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;early endosome membrane;endosome membrane;intracellular organelle;melanosome;membrane;membrane-bounded organelle;membrane-bounded vesicle;nucleus;organelle;organelle membrane;plasma membrane;vesicle binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity cell communication;cellular process;establishment of protein localization;intracellular signaling cascade;protein transport;regulation of biological process;signal transduction;small GTPase mediated signal transduction;transport 8 8 5 44.9 44.9 30.1 23.482 2.4098E-110 723390000 368510000 354890000 1298 IPI:IPI00016339.4 Ras-related protein Rab-5C;RAB5L;L1880 RAB5C;RABL P51148 ENST00000346213;ENST00000393860 K07889 1 0.95764 1.75 0.91767 1.23 1.1724 1.2199 Ras cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;endocytic vesicle;endosome;Golgi apparatus;intracellular organelle;late endosome;lysosome;lytic vacuole;melanosome;membrane-bounded organelle;membrane-bounded vesicle;organelle;vacuole;vesicle binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity cell communication;cellular component organization;cellular process;endocytosis;intracellular signaling cascade;membrane invagination;membrane organization;protein transport;signal transduction;small GTPase mediated signal transduction;transport 15 15 15 75.4 75.4 75.4 23.489 0 2261700000 1161600000 1100100000 1299 IPI:IPI00016342.1 Ras-related protein Rab-7a RAB7A;RAB7 P51149 ENST00000265062 K07897 1 0.73529 1.6018 0.79271 0.96915 1.0375 1.053 Ala_racemase_N cell part;cytoplasm;intracellular part 11 11 11 47.6 47.6 47.6 30.344 5.2777E-171 313170000 172810000 140350000 1300 IPI:IPI00016346.1 Proline synthetase co-transcribed bacterial homolog protein PROSC O94903 ENST00000328195 K06997 1 0.78296 1.3711 0.84191 0.97402 0.95982 1.0132 Ras endoplasmic reticulum membrane;endosome;Golgi membrane;intracellular membrane-bounded organelle;intracellular organelle;late endosome;lysosome;lytic vacuole;membrane;membrane-bounded organelle;organelle;organelle membrane;plasma membrane;vacuole binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleotide binding;pyrophosphatase activity cell communication;cellular process;establishment of protein localization;intracellular signaling cascade;protein transport;regulation of biological process;signal transduction;small GTPase mediated signal transduction;transport 2 2 2 12.9 12.9 12.9 22.837 3.1397E-37 15144000 8059000 7084500 1301 IPI:IPI00016372.1 Ras-related protein Rab-9A RAB9A;RAB9 P51151 ENST00000243325 K07899 1 0.76469 2.249 0.83339 1.052 1.3729 1.2206 Ras cell projection;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;dendrite;intracellular membrane-bounded organelle;intracellular organelle;melanosome;membrane;membrane-bounded organelle;membrane-bounded vesicle;neuron projection;organelle;vesicle binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleotide binding;pyrophosphatase activity cell communication;cellular process;establishment of protein localization;intracellular signaling cascade;protein transport;regulation of biological process;signal transduction;small GTPase mediated signal transduction;transport 3 3 3 15.8 15.8 15.8 24.868 1.1546E-16 10811000 6037800 4773400 1303 IPI:IPI00016381.2;IPI:IPI00219858.6 Ras-related protein Rab-27A;GTP-binding protein Ram RAB27A;RAB27 P51159-1;P51159;P51159-2 ENST00000336787;ENST00000396304;ENST00000396307 K07885 2 0.59108 1.0945 0.59266 0.74732 0.72288 0.82471 DUF618 cell part;intracellular organelle part;intracellular part;macromolecular complex;mRNA cleavage factor complex;nuclear part;nucleoplasm part;organelle part;protein complex mRNA cleavage;nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 9 9 9 7.5 7.5 7.5 173.05 3.3524E-32 24349000 12625000 11724000 1304 IPI:IPI00016387.4 Pre-mRNA cleavage complex 2 protein Pcf11;Pre-mRNA cleavage complex II protein Pcf11 PCF11;KIAA0824 O94913 ENST00000298281 1 0.59784 1.3069 0.68954 0.8176 0.87325 0.93312 OCIA cell part;cytoplasmic part;endosome;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle 8 8 8 37.6 37.6 37.6 27.626 1.0121E-127 258290000 145430000 112850000 1305 IPI:IPI00016405.1;IPI:IPI00816371.1 OCIA domain-containing protein 1;Ovarian carcinoma immunoreactive antigen OCIAD1;OCIA Q9NX40-1;Q9NX40;Q9NX40-2 ENST00000264312;ENST00000381473;ENST00000396448 2 0.68146 1.6872 NaN 0.95065 1.1066 NaN Acyltransferase;efhand cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;Golgi apparatus part;Golgi membrane;Golgi stack;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part acetyltransferase activity;acyltransferase activity;binding;calcium ion binding;catalytic activity;O-acetyltransferase activity;O-acyltransferase activity;transferase activity;transferase activity, transferring acyl groups alcohol metabolic process;biogenic amine metabolic process;cellular amino acid and derivative metabolic process;cellular amino acid derivative metabolic process;glycerophospholipid metabolic process;lipid metabolic process;phospholipid metabolic process 4 4 4 7.2 7.2 7.2 60.207 1.3029E-16 11021000 6425900 4594700 1306 IPI:IPI00016418.3;IPI:IPI00643943.2 Lysophosphatidylcholine acyltransferase 2;1-alkylglycerophosphocholine O-acetyltransferase;Acetyl-CoA:lyso-platelet-activating factor acetyltransferase;1-acylglycerophosphocholine O-acyltransferase;Acyltransferase-like 1 LPCAT2;AYTL1 Q7L5N7-1;Q7L5N7;Q7L5N7-2 ENST00000262134 2 NaN 2.0104 0.76112 NaN 1.2905 1.0139 HCaRG binding;protein binding 2 2 2 19.7 19.7 19.7 21.09 4.3431E-27 39853000 22046000 17807000 1308 IPI:IPI00016447.5 COMM domain-containing protein 8 COMMD8;MDS022 Q9NX08 ENST00000306848;ENST00000381571 1 0.73732 1.7148 NaN 0.99882 1.1044 NaN Carn_acyltransf endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;membrane;membrane-bounded organelle;microbody;mitochondrial inner membrane;mitochondrial membrane;organelle;organelle inner membrane;organelle membrane;peroxisome acetyltransferase activity;acyltransferase activity;carnitine O-acetyltransferase activity;carnitine O-acyltransferase activity;catalytic activity;O-acetyltransferase activity;O-acyltransferase activity;transferase activity cellular process;energy derivation by oxidation of organic compounds;fatty acid metabolic process;generation of precursor metabolites and energy;lipid metabolic process;metabolic process;organic acid metabolic process;transport Alanine and aspartate metabolism 5 5 5 9.3 9.3 9.3 70.857 1.9912E-12 3275700 1801400 1474300 1310 IPI:IPI00016457.5;IPI:IPI00514595.3;IPI:IPI00029140.7 Carnitine O-acetyltransferase;Carnitine acetyltransferase CRAT;CAT1 P43155-1;P43155;P43155-2;P43155-3 ENST00000318080;ENST00000351352;ENST00000372536 K00624 3 0.82179 1.491 NaN 1.0373 1.0199 NaN DAO integral to membrane;integral to mitochondrial inner membrane;integral to mitochondrial membrane;integral to organelle membrane;intrinsic to membrane;intrinsic to mitochondrial inner membrane;intrinsic to organelle membrane;organelle part 2-hydroxyglutarate dehydrogenase activity;catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors biopolymer metabolic process;cellular biopolymer metabolic process;cellular macromolecule metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein metabolic process Butanoate metabolism 8 8 8 21.4 21.4 21.4 50.359 1.5416E-111 18034000 9520500 8513500 1311 IPI:IPI00016458.2;IPI:IPI00029239.1 L-2-hydroxyglutarate dehydrogenase, mitochondrial L2HGDH;C14orf160 Q9H9P8-1;Q9H9P8;Q9H9P8-2 ENST00000261699;ENST00000267436 K00109 2 NaN 1.1 0.9532 NaN 0.75448 1.2604 2 2 2 13.2 13.2 13.2 30.462 0.0011749 6653400 3193100 3460300 1312 IPI:IPI00016478.6;IPI:IPI00828185.1 Uncharacterized protein C1orf109 C1orf109 Q9NX04-1;Q9NX04;Q9NX04-2 ENST00000358011 2 0.85029 1.7398 0.81011 1.1315 1.1268 1.0607 Ras cell part;membrane;plasma membrane binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;protein binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cell communication;cellular process;establishment of protein localization;intracellular signaling cascade;protein transport;regulation of biological process;signal transduction;small GTPase mediated signal transduction;transport 16 14 10 68.5 62 47.5 22.541 1.7061E-131 1247400000 655900000 591460000 1313 IPI:IPI00016513.5 Ras-related protein Rab-10 RAB10 P61026 ENST00000264710 K07903 1 0.873 1.463 0.93975 1.2565 0.8905 1.2453 DUF2228 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 16 16 16 46.2 46.2 46.2 39.408 5.7348E-249 339370000 169390000 169990000 1314 IPI:IPI00016532.3;IPI:IPI00871134.1 UPF0609 protein C4orf27 C4orf27 Q9NWY4 ENST00000261511 2 0.34133 0.49743 0.34502 0.46757 0.35411 0.43269 WD40 7 7 7 13.6 13.6 13.6 69.752 6.0579E-10 32991000 19241000 13750000 1315 IPI:IPI00016542.5 WD repeat-containing protein 76 WDR76 Q9H967 ENST00000263795 1 0.76146 1.5259 0.85696 1.0025 1.079 1.0529 Ank;SOCS_box cell part;cytoplasm;intracellular part catabolic process;cell communication;cellular process;intracellular signaling cascade;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein metabolic process;proteolysis;signal transduction 3 3 3 10.9 10.9 10.9 47.135 2.7602E-24 32724000 16753000 15971000 1316 IPI:IPI00016560.3 Ankyrin repeat and SOCS box protein 6 ASB6 Q9NWX5 ENST00000277458 K10328 1 0.69239 1.3981 0.69999 0.86033 0.9701 0.89238 ADK;ADK_lid cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part adenylate kinase activity;ATP binding;binding;catalytic activity;GTP binding;kinase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups cellular metabolic process;cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;primary metabolic process Purine metabolism 4 4 4 19.7 19.7 19.7 25.268 5.8591E-35 45553000 25517000 20036000 1317 IPI:IPI00016568.1 Adenylate kinase isoenzyme 4, mitochondrial;Adenylate kinase 3-like;ATP-AMP transphosphorylase AK3L1;AK3;AK4;AK3L2 P27144 ENST00000294419;ENST00000327299;ENST00000395334 K00939 1 0.88009 1.4372 0.85337 1.0947 0.99284 1.064 LSM cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;ribonucleoprotein complex;small nuclear ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;protein binding;RNA binding cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 2 2 2 17.1 17.1 17.1 8.544 1.6918E-44 674570000 342550000 332030000 1318 IPI:IPI00745343.2;IPI:IPI00016572.1 Small nuclear ribonucleoprotein G-like protein;Small nuclear ribonucleoprotein G SNRPG;PBSCG A8MWD9;P62308 ENST00000272348 K11099 2 0.63723 0.9545 NaN 0.86761 0.63524 NaN Mis12_component chromosomal part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;MIS12/MIND type complex;nucleus;organelle;organelle part;protein complex binding;protein binding cell cycle phase;cell cycle process;cell division;cellular component organization;cellular process;chromosome segregation;mitosis;nuclear division;organelle fission;organelle organization 4 4 4 17.1 17.1 17.1 40.067 1.6069E-112 3814500 2198400 1616100 1319 IPI:IPI00016580.6;IPI:IPI00843750.1 Kinetochore-associated protein DSN1 homolog DSN1;C20orf172 Q9H410-1;Q9H410;Q9H410-2 ENST00000373733;ENST00000373745;ENST00000373750 K11544 2 1.0078 1.8441 0.97289 1.3112 1.184 1.2318 CS;DUF1872;UCH;zf-MYND binding;catalytic activity;cation binding;cysteine-type peptidase activity;hydrolase activity;hydrolase activity, acting on ester bonds;ion binding;peptidase activity;thiolester hydrolase activity;ubiquitin thiolesterase activity;zinc ion binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process 9 9 9 8.3 8.3 8.3 145.65 1.0226E-52 75637000 36439000 39198000 1320 IPI:IPI00016589.5;IPI:IPI00853489.1;IPI:IPI00797161.4;IPI:IPI00654743.2 Ubiquitin carboxyl-terminal hydrolase 19;Ubiquitin thioesterase 19;Ubiquitin-specific-processing protease 19;Deubiquitinating enzyme 19;Zinc finger MYND domain-containing protein 9 USP19;KIAA0891;ZMYND9 O94966-1;O94966;O94966-3;O94966-4 ENST00000306026;ENST00000398888;ENST00000398892;ENST00000398909 K11847 4 0.78097 1.4902 0.80057 1.0397 0.9913 1.0512 DUF866 5 5 5 45 45 45 18.048 9.6251E-52 324820000 174360000 150450000 1321 IPI:IPI00016605.3 UPF0587 protein C1orf123 C1orf123 Q9NWV4 ENST00000294360 1 0.93741 1.7718 0.84864 1.2306 1.1591 1.2561 EMP24_GP25L cell fraction;coated vesicle membrane;cytoplasmic vesicle membrane;ER-Golgi intermediate compartment;Golgi membrane;Golgi-associated vesicle membrane;insoluble fraction;integral to membrane;membrane;membrane fraction;microsome;vesicle membrane binding;protein binding cellular process;establishment of localization;establishment of protein localization;protein transport;transport;vesicle-mediated transport 4 4 4 30.8 30.8 30.8 22.761 1.9739E-33 96070000 51810000 44260000 1322 IPI:IPI00016608.1 Transmembrane emp24 domain-containing protein 2 TMED2;RNP24 Q15363 ENST00000262225 1 0.75921 1.364 0.79649 0.98369 0.89677 1.032 KH_1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;ribonucleoprotein complex binding;DNA binding;nucleic acid binding;protein binding;RNA binding;single-stranded DNA binding;structure-specific DNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 13 10 10 63.8 55.1 55.1 37.497 0 4951300000 2518600000 2432700000 1323 IPI:IPI00016610.2 Poly(rC)-binding protein 1;Alpha-CP1;Nucleic acid-binding protein SUB2.3 PCBP1 Q15365 ENST00000303577 1 0.63243 2.0848 0.75562 0.88181 1.3417 0.99186 LisH;RanBPM_CRA cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding 5 5 5 32.9 32.9 32.9 26.748 4.8557E-158 35902000 19378000 16525000 1324 IPI:IPI00016634.1 Protein C20orf11;Two hybrid-associated protein 1 with RanBPM C20orf11 Q9NWU2 ENST00000266069 1 0.82614 1.4295 0.73204 1.0231 1.0071 0.89988 ketoacyl-synt;Ketoacyl-synt_C cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle 3-oxoacyl-[acyl-carrier-protein] synthase activity;acyltransferase activity;catalytic activity;fatty-acid synthase activity;transferase activity;transferase activity, transferring acyl groups acyl-CoA metabolic process;biosynthetic process;cellular process;coenzyme metabolic process;fatty acid biosynthetic process;fatty acid metabolic process;lipid biosynthetic process;lipid metabolic process;metabolic process;organic acid metabolic process Fatty acid biosynthesis 3 3 3 10.7 10.7 10.7 48.842 1.1911E-117 5904300 3286300 2618000 1325 IPI:IPI00016637.3 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial;Beta-ketoacyl-ACP synthase OXSM Q9NWU1 ENST00000280701 K09458 1 0.52423 0.94853 0.5316 0.64357 0.53684 0.65222 C1_1;PB1;Pkinase;Pkinase_C cell cortex part;cell part;cytoplasmic part;cytosol;endosome;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;polarisome;protein complex ATP binding;binding;catalytic activity;nucleoside binding;nucleotide binding;phospholipid binding;protein binding;protein kinase activity;protein kinase C activity;protein serine/threonine kinase activity;purine nucleoside binding;zinc ion binding cell communication;intracellular protein transport;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;protein targeting;protein targeting to membrane;transport Insulin signaling pathway;Tight junction 3 3 3 8.2 8.2 8.2 68.262 6.8196E-68 18827000 11367000 7460000 1326 IPI:IPI00016639.7 Protein kinase C iota type;nPKC-iota;Atypical protein kinase C-lambda/iota PRKCI;DXS1179E P41743 ENST00000295797;ENST00000392722 K06069 1 0.78512 1.4505 0.78249 1.2995 0.91934 1.1206 Ras cell part;cytoplasmic part;cytosol;intracellular part;membrane;plasma membrane binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleotide binding;pyrophosphatase activity biological regulation;cell communication;cellular process;intracellular signaling cascade;regulation of biological process;regulation of cellular process;signal transduction;small GTPase mediated signal transduction Insulin signaling pathway;mTOR signaling pathway 6 6 6 23.4 23.4 23.4 20.497 1.1689E-22 60146000 32066000 28080000 1327 IPI:IPI00016669.1 GTP-binding protein Rheb;Ras homolog enriched in brain RHEB;RHEB2 Q15382 ENST00000262187 K07208 1 0.94197 1.7431 0.95202 1.2458 1.2218 1.2409 5 5 5 41 41 41 17.745 1.4168E-87 479830000 249010000 230820000 1328 IPI:IPI00016670.3 UPF0404 protein C11orf59 C11orf59;PP7157 Q6IAA8 ENST00000278671 1 0.64722 1.8372 0.69452 0.9519 1.0678 1.0093 MAS20 cytoplasmic part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;macromolecular complex;membrane part;mitochondrial outer membrane translocase complex;mitochondrial part;organelle part;protein complex binding;P-P-bond-hydrolysis-driven transmembrane transporter activity;primary active transmembrane transporter activity;protein binding;protein transmembrane transporter activity;protein transporter activity;transporter activity establishment of localization;establishment of localization in cell;establishment of protein localization;intracellular protein transport;intracellular transport;protein targeting;protein transport;transport 3 3 3 20.7 20.7 20.7 16.298 1.1537E-12 55025000 28835000 26190000 1329 IPI:IPI00016676.1 Mitochondrial import receptor subunit TOM20 homolog;Mitochondrial 20 kDa outer membrane protein;Outer mitochondrial membrane receptor Tom20 TOMM20;KIAA0016 Q15388 ENST00000366607 1 0.95839 1.7808 0.92379 1.3184 1.1344 1.258 PID;TBC centrosome;cytosol;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;microtubule associated complex;microtubule organizing center;non-membrane-bounded organelle;organelle;organelle part;protein complex binding;cytoskeletal protein binding;enzyme activator activity;enzyme regulator activity;GTPase activator activity;protein binding;Rab GTPase activator activity;Ras GTPase activator activity;small GTPase regulator activity;tubulin binding biological regulation;cell cycle;cellular process;regulation of catalytic activity;regulation of GTPase activity;regulation of hydrolase activity;regulation of molecular function;regulation of Rab GTPase activity;regulation of Ras GTPase activity 15 15 13 16.2 16.2 14.8 121.74 3.6441E-80 138090000 69853000 68234000 1331 IPI:IPI00016702.4;IPI:IPI00856033.1;IPI:IPI00855799.1;IPI:IPI00386898.9;IPI:IPI00465119.1;IPI:IPI00641910.1;IPI:IPI00646639.1;IPI:IPI00006648.4 Rab GTPase-activating protein 1;Rab6 GTPase-activating protein GAPCenA;GAP and centrosome-associated protein RABGAP1;HSPC094 Q9Y3P9-1;Q9Y3P9;Q9Y3P9-2;Q9Y3P9-3 ENST00000373643 8 0.65695 1.1645 0.61194 0.86765 0.74084 0.80092 FAD_binding_4 endoplasmic reticulum membrane;Golgi membrane;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intrinsic to membrane;membrane;membrane-bounded organelle;nucleus;organelle;organelle membrane;organelle part antigen binding;binding;catalytic activity;nucleoside binding;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on the CH-CH group of donors;protein binding;purine nucleoside binding alcohol metabolic process;anti-apoptosis;apoptosis;cell cycle arrest;cholesterol biosynthetic process;lipid metabolic process;metabolic process;response to oxidative stress;response to stress;steroid biosynthetic process;steroid metabolic process Biosynthesis of steroids 9 9 9 16.9 16.9 16.9 60.101 2.9553E-63 225890000 124500000 101380000 1332 IPI:IPI00016703.2 24-dehydrocholesterol reductase;3-beta-hydroxysterol delta-24-reductase;Seladin-1;Diminuto/dwarf1 homolog DHCR24;KIAA0018 Q15392 ENST00000371269 K09828 1 0.48968 0.99208 0.54475 0.67912 0.67079 0.68644 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex;transcription factor TFIIIC complex binding;catalytic activity;DNA binding;enzyme activator activity;H3/H4 histone acetyltransferase activity;histone acetyltransferase activity;lysine N-acetyltransferase activity;N-acetyltransferase activity;nucleic acid binding;protein binding nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription;transcription from RNA polymerase III promoter;transcription initiation;transcription initiation from RNA polymerase III promoter;transcription, DNA-dependent 17 17 17 23.8 23.8 23.8 91.981 5.5725E-98 168710000 96459000 72253000 1333 IPI:IPI00016725.2 General transcription factor 3C polypeptide 4;Transcription factor IIIC subunit delta;TF3C-delta;TFIIIC 90 kDa subunit GTF3C4 Q9UKN8 ENST00000372146 K11310 1 0.82813 1.5168 0.84762 1.0646 0.99124 1.0858 C2;PH;PI-PLC-X;PI-PLC-Y;SH2;SH3_1 cell part;cytoplasmic part;cytosol;intracellular part;membrane;plasma membrane binding;catalytic activity;inositol or phosphatidylinositol phosphodiesterase activity;phosphoinositide phospholipase C activity;phospholipase activity;phospholipase C activity;receptor signaling protein activity;signal transducer activity catabolic process;cell communication;cellular process;intracellular signaling cascade;lipid catabolic process;lipid metabolic process;metabolic process;phospholipid catabolic process;phospholipid metabolic process;signal transduction 24 24 24 25.2 25.2 25.2 148.53 1.1946E-276 759100000 385630000 373470000 1336 IPI:IPI00016736.1 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1;Phosphoinositide phospholipase C;Phospholipase C-gamma-1;PLC-II;PLC-148 PLCG1;PLC1 P19174 ENST00000244007;ENST00000373271 1 NaN 1.0589 NaN NaN 0.65978 NaN Mur_ligase_C cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle acid-amino acid ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleoside binding;nucleotide binding;purine nucleoside binding;tetrahydrofolylpolyglutamate synthase activity cellular aromatic compound metabolic process;coenzyme metabolic process;group transfer coenzyme metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;one-carbon metabolic process;organic acid metabolic process Folate biosynthesis 2 2 2 6.1 6.1 6.1 64.608 5.4956E-56 8366500 4213400 4153100 1337 IPI:IPI00016745.1;IPI:IPI00759584.1 Folylpolyglutamate synthase, mitochondrial;Folylpoly-gamma-glutamate synthetase;Tetrahydrofolylpolyglutamate synthase FPGS Q05932-1;Q05932;Q05932-2 ENST00000373247 K01930 2 1.1061 1.2508 0.87935 1.4549 0.84545 1.1197 CBF_beta cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;protein binding;RNA polymerase II transcription factor activity;transcription coactivator activity;transcription cofactor activity;transcription factor activity;transcription factor binding biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent 9 1 1 40.1 5.5 5.5 21.508 2.4828E-170 175220000 88973000 86249000 1338 IPI:IPI00016746.1 Core-binding factor subunit beta;Polyomavirus enhancer-binding protein 2 beta subunit;SL3-3 enhancer factor 1 subunit beta;SL3/AKV core-binding factor beta subunit CBFB Q13951-1;Q13951 ENST00000290858 1 0.79114 1.7336 0.82663 1.0606 1.1018 1.1003 Ras cell part;cell projection;cytoplasmic part;cytosol;filopodium;intracellular part;membrane;plasma membrane binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity cell communication;cytoskeleton organization;establishment or maintenance of cell polarity;intracellular signaling cascade;leukocyte differentiation;myeloid leukocyte differentiation;organelle organization;signal transduction Adherens junction;Axon guidance;Chemokine signaling pathway;Epithelial cell signaling in Helicobacter pylori infection;Focal adhesion;GnRH signaling pathway;Leukocyte transendothelial migration;MAPK signaling pathway;MAPK signaling pathway - yeast;Pancreatic cancer;Pathways in cancer;Regulation of actin cytoskeleton;Renal cell carcinoma;T cell receptor signaling pathway;Tight junction;VEGF signaling pathway 8 7 7 44 38.2 38.2 21.258 2.1584E-72 1126700000 595970000 530720000 1340 IPI:IPI00016786.1;IPI:IPI00007189.1 Cell division control protein 42 homolog;G25K GTP-binding protein CDC42 P60953-2;P60953;P60953-1 ENST00000315554;ENST00000337517;ENST00000400259 K04393 2 0.76782 1.5735 0.73522 0.99654 1.0216 0.96327 ELFV_dehydrog;ELFV_dehydrog_N cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part ATP binding;binding;catalytic activity;glutamate dehydrogenase [NAD(P)+] activity;glutamate dehydrogenase activity;GTP binding;nucleoside binding;nucleotide binding;oxidoreductase activity;purine nucleoside binding cell communication;cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;glutamate catabolic process;glutamate metabolic process;nitrogen compound metabolic process;organic acid metabolic process;signal transduction Arginine and proline metabolism;D-Glutamine and D-glutamate metabolism;Glutamate metabolism;Nitrogen metabolism 28 28 28 56.3 56.3 56.3 61.397 0 2727100000 1424400000 1302800000 1341 IPI:IPI00016801.1;IPI:IPI00027146.1 Glutamate dehydrogenase 1, mitochondrial;Glutamate dehydrogenase 2, mitochondrial GLUD1;GLUD;GLUD2;GLUDP1 P00367;P49448 ENST00000277865;ENST00000328078 K00261 2 0.726 1.445 0.69137 0.94273 0.84914 0.98278 SIR2 cytoplasm;envelope;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;nuclear body;nuclear envelope;nuclear part;nucleolus;organelle;organelle envelope;organelle part;PML body binding;catalytic activity;histone deacetylase activity;nucleotide binding;p53 binding;protein binding;protein C-terminus binding;transcription cofactor activity;transcription corepressor activity;transcription factor binding;zinc ion binding chromatin organization;chromatin remodeling;DNA metabolic process;DNA repair;DNA replication;establishment of chromatin silencing;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of chromatin assembly or disassembly 6 6 6 12 12 12 81.68 6.7826E-52 23977000 12709000 11268000 1342 IPI:IPI00016802.1 NAD-dependent deacetylase sirtuin-1;SIR2-like protein 1 SIRT1;SIR2L1 Q96EB6 ENST00000212015 K11411 1 0.78829 1.7331 0.85733 1.0846 1.1154 1.1036 Proteasome;Proteasome_A_N cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;polysome;proteasome core complex;protein complex;ribonucleoprotein complex binding;catalytic activity;endopeptidase activity;hydrolase activity;nucleic acid binding;peptidase activity;protein binding;RNA binding;threonine-type endopeptidase activity;threonine-type peptidase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Proteasome 12 12 12 51.3 51.3 51.3 30.239 0 4132400000 2173600000 1958800000 1343 IPI:IPI00472442.4;IPI:IPI00016832.1 Proteasome subunit alpha type-1;Proteasome component C2;Macropain subunit C2;Multicatalytic endopeptidase complex subunit C2;Proteasome nu chain;30 kDa prosomal protein;PROS-30 PSMA1;PROS30;PSC2 P25786-2;P25786;P25786-1 ENST00000249924;ENST00000322215;ENST00000396393 K02725 2 0.48472 1.3139 0.46288 0.65229 0.83342 0.62383 Tfb2 cell part;holo TFIIH complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex binding;DNA binding;nucleic acid binding;protein binding;RNA polymerase II transcription factor activity;transcription factor activity;transcription regulator activity DNA catabolic process;DNA metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleotide-excision repair, DNA damage removal;regulation of transcription, DNA-dependent;RNA elongation;transcription initiation Basal transcription factors;Nucleotide excision repair 3 3 3 8.9 8.9 8.9 52.186 7.3794E-23 6014600 3633000 2381600 1344 IPI:IPI00016839.1 General transcription factor IIH subunit 4;General transcription factor IIH polypeptide 4;TFIIH basal transcription factor complex p52 subunit;Basic transcription factor 2 52 kDa subunit;BTF2-p52 GTF2H4 Q92759 ENST00000259895;ENST00000376316;ENST00000376326;ENST00000383358;ENST00000400392;ENST00000400450 K03144 1 0.8326 1.3189 NaN 1.1618 0.84977 NaN BRF1;TFIIB;TFIIB_Zn_Ribbon cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex;transcription factor TFIIIB complex binding;DNA binding;nucleic acid binding;protein binding;RNA polymerase III transcription factor activity;transcription factor activity;translation factor activity, nucleic acid binding;translation initiation factor activity;zinc ion binding nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription;transcription initiation;transcription initiation from RNA polymerase III promoter;transcription, DNA-dependent 4 4 4 6.4 6.4 6.4 73.839 0.00020924 11847000 7078500 4768100 1345 IPI:IPI00016859.2;IPI:IPI00607889.1;IPI:IPI00157643.1;IPI:IPI00216075.1 Transcription factor IIIB 90 kDa subunit;B-related factor 1;TATA box-binding protein-associated factor, RNA polymerase III, subunit 2;TAF3B2 BRF1;BRF;GTF3B;TAF3B2;TAF3C Q92994-1;Q92994;Q92994-5;Q92994-3 ENST00000327359;ENST00000332890;ENST00000345053;ENST00000379937;ENST00000392557 4 0.81271 1.5654 0.73612 1.0695 1.0419 1.013 Pyr_redox;Pyr_redox_2;Pyr_redox_dim cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle binding;catalytic activity;disulfide oxidoreductase activity;electron carrier activity;glutathione-disulfide reductase activity;nucleoside binding;nucleotide binding;peptide disulfide oxidoreductase activity;purine nucleoside binding cellular amino acid and derivative metabolic process;cellular amino acid derivative metabolic process;cellular process;coenzyme metabolic process;glutathione metabolic process;metabolic process;peptide metabolic process;sulfur metabolic process Glutathione metabolism 15 15 15 44.6 44.6 44.6 56.256 1.2992E-217 1913300000 1016100000 897200000 1346 IPI:IPI00016862.1;IPI:IPI00759575.1 Glutathione reductase, mitochondrial GSR;GLUR;GRD1 P00390-1;P00390;P00390-2 ENST00000221130 K00383 2 0.35253 0.67143 0.36941 0.45315 0.46608 0.46284 Telomere_reg-2 cell part;chromosomal part;chromosome, telomeric region;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane;membrane-bounded organelle;nucleus;organelle;organelle part binding;protein binding 14 14 14 21.7 21.7 21.7 91.746 1.1859E-171 184910000 106750000 78166000 1347 IPI:IPI00016868.3 Telomere length regulation protein TEL2 homolog;Protein clk-2 homolog TELO2;KIAA0683 Q9Y4R8 ENST00000262319 K11137 1 NaN 1.8229 NaN NaN 1.1052 NaN Ras cell part;cytoplasmic part;Golgi apparatus part;Golgi membrane;intracellular organelle part;intracellular part;membrane;organelle membrane;organelle part binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleotide binding;pyrophosphatase activity cell communication;cellular process;intracellular signaling cascade;protein transport;retrograde vesicle-mediated transport, Golgi to ER;signal transduction;small GTPase mediated signal transduction;transport;vesicle-mediated transport 7 1 1 28.8 6.7 6.7 23.461 2.6178E-79 296670 179780 116890 1348 IPI:IPI00016891.1;IPI:IPI00030304.2 Ras-related protein Rab-6B RAB6B Q9NRW1 ENST00000285208 K07894 2 0.74712 1.4068 0.77053 0.97379 0.93946 0.96496 eIF-3c_N;PCI cell part;cytoplasmic part;cytosol;eukaryotic translation initiation factor 3 complex;intracellular part;macromolecular complex;protein complex binding;nucleic acid binding;protein binding;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity cellular process;translational initiation 32 32 32 32.4 32.4 32.4 105.34 0 3027600000 1583600000 1444000000 1350 IPI:IPI00016910.1 Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit 8;eIF3 p110 EIF3C;EIF3S8;EIF3CL Q99613 ENST00000331666;ENST00000395587 K03252 1 0.95134 1.7066 0.82232 1.2004 1.0836 1.1089 TPR_1 binding;protein binding;unfolded protein binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 6 6 6 24.3 24.3 24.3 33.526 3.8146E-55 464910000 238760000 226150000 1351 IPI:IPI00016912.1 Tetratricopeptide repeat protein 1 TTC1;TPR1 Q99614 ENST00000231238 1 0.74687 1.1812 0.75886 1.0019 0.80009 1.015 4 4 4 51.6 51.6 51.6 13.178 1.0307E-147 107860000 55066000 52798000 1352 IPI:IPI00016925.1 Protein C10 C12orf57;C10 Q99622 ENST00000229281 1 0.81436 1.668 0.85223 1.1275 1.1086 1.1335 DUF605 cell part;cytoplasmic part;endosomal part;endosome membrane;intracellular organelle part;intracellular part;membrane;organelle membrane;organelle part establishment of localization;establishment of protein localization;protein transport;transport 10 10 10 36.5 36.5 36.5 33.879 1.9051E-216 635200000 333230000 301970000 1354 IPI:IPI00017160.3 Vacuolar protein sorting-associated protein VTA1 homolog;Dopamine-responsive protein DRG-1;SKD1 binding protein 1;LYST-interacting protein 5 VTA1;C6orf55;HSPC228;My012 Q9NP79 ENST00000367630 K12199 1 0.59062 1.2145 0.68337 0.81739 0.78636 0.835 Dynamin_N cell part;cytoplasmic part;early endosome membrane;endosomal part;endosome membrane;intracellular organelle part;intracellular part;membrane;organelle membrane;organelle part;plasma membrane;recycling endosome membrane ATP binding;binding;calcium ion binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity 19 19 15 41.2 41.2 30.9 60.626 6.3093E-92 322510000 179340000 143170000 1355 IPI:IPI00017184.2 EH domain-containing protein 1;Testilin;hPAST1 EHD1;PAST;PAST1;CDABP0131 Q9H4M9 ENST00000320631;ENST00000359393 1 0.46586 0.88458 0.42913 0.61412 0.57255 0.57918 LRR_1 binding;protein binding biological regulation;cell communication;cellular process;regulation of biological process;regulation of cellular process;signal transduction 6 6 6 19.5 19.5 19.5 31.54 8.4307E-40 188520000 110020000 78500000 1356 IPI:IPI00017256.6 Ras suppressor protein 1 RSU1;RSP1 Q15404 ENST00000345264;ENST00000377912;ENST00000377921 1 0.80482 1.6381 0.7882 1.0659 1.0772 1.0439 Anticodon_1;tRNA-synt_1;zf-FPG_IleRS cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;isoleucine-tRNA ligase activity;ligase activity;ligase activity, forming carbon-oxygen bonds;nucleoside binding;nucleotide binding;purine nucleoside binding;zinc ion binding cellular amino acid and derivative metabolic process;isoleucyl-tRNA aminoacylation;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;tRNA aminoacylation for protein translation;tRNA metabolic process Aminoacyl-tRNA biosynthesis;Valine, leucine and isoleucine biosynthesis 28 28 28 32.6 32.6 32.6 113.79 0 960570000 502250000 458320000 1357 IPI:IPI00017283.2 Isoleucyl-tRNA synthetase, mitochondrial;Isoleucine--tRNA ligase IARS2 Q9NSE4 ENST00000302637 K01870 1 0.7343 1.419 0.69539 0.94184 0.94082 0.91042 cell part;intracellular organelle part;intracellular part;membrane;nuclear inner membrane;nuclear matrix;nuclear membrane;nuclear part;organelle inner membrane;organelle membrane;organelle part binding;cation binding;ion binding;metal ion binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding;structural molecule activity;transition metal ion binding;zinc ion binding 33 33 33 36.2 36.2 36.2 94.622 0 5613100000 2966600000 2646500000 1359 IPI:IPI00017297.1 Matrin-3 MATR3;KIAA0723 P43243 ENST00000361059;ENST00000394800;ENST00000394805 1 0.48437 1.0269 0.47891 0.64183 0.65233 0.6579 Pkinase;Pkinase_C cell part;cytoplasm;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part ATP binding;binding;catalytic activity;kinase activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cell communication;cellular process;intracellular signaling cascade;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein kinase cascade;protein modification process;signal transduction Long-term potentiation;MAPK signaling pathway;mTOR signaling pathway;Progesterone-mediated oocyte maturation 15 7 7 23.9 12.7 12.7 82.722 4.8236E-120 77425000 44683000 32742000 1361 IPI:IPI00017305.2;IPI:IPI00007123.1;IPI:IPI00914890.1;IPI:IPI00894093.2;IPI:IPI00827896.6;IPI:IPI00788168.4;IPI:IPI00027883.2 Ribosomal protein S6 kinase alpha-1;90 kDa ribosomal protein S6 kinase 1;p90-RSK 1;pp90RSK1;p90S6K;Ribosomal S6 kinase 1;MAP kinase-activated protein kinase 1a RPS6KA1;RSK1 Q15418 ENST00000374162;ENST00000374168 K04373 7 0.70568 1.4729 0.69476 0.89567 0.99287 0.90885 Band_7 integral to membrane;integral to plasma membrane;intracellular part;intrinsic to membrane;intrinsic to plasma membrane;membrane;mitochondrial inner membrane;mitochondrial membrane;nucleoplasm;organelle inner membrane;organelle membrane;organelle part binding;protein binding;transcription activator activity;transcription regulator activity;transcription repressor activity chromatin organization;DNA metabolic process;DNA replication;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;protein amino acid deacetylation;protein modification process 11 11 11 50.4 50.4 50.4 29.804 3.07E-269 1379100000 743270000 635840000 1362 IPI:IPI00017334.1 Prohibitin PHB P35232 ENST00000300408 1 0.80596 1.4665 0.83492 1.0322 0.9649 1.0457 RRM_1 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;catalytic activity;nucleic acid binding;nucleotide binding;protein binding;RNA binding;RNA splicing factor activity, transesterification mechanism nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 6 6 6 20.8 20.8 20.8 44.385 4.7307E-211 304710000 154540000 150170000 1363 IPI:IPI00017339.1 Splicing factor 3B subunit 4;Spliceosome-associated protein 49;SF3b50;Pre-mRNA-splicing factor SF3b 49 kDa subunit SF3B4;SAP49 Q15427 ENST00000271628 1 0.76649 1.5886 0.79389 1.0746 1.0041 1.0694 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;small nuclear ribonucleoprotein complex;spliceosomal complex binding;cation binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding anatomical structure formation;cellular component assembly;cellular component organization;cellular process;mRNA splice site selection;nuclear mRNA 3'-splice site recognition;ribonucleoprotein complex assembly 11 11 11 19.1 19.1 19.1 51.475 2.3148E-203 612950000 323650000 289310000 1364 IPI:IPI00017341.3 Splicing factor 3A subunit 2;Spliceosome-associated protein 62;SF3a66 SF3A2;SAP62 Q15428 ENST00000221494 1 0.8038 1.5399 0.817 1.0896 1.0298 1.0903 Ras cell part;intracellular;membrane;plasma membrane binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity cell communication;cellular process;intracellular signaling cascade;positive regulation of cell proliferation;Ras protein signal transduction;Rho protein signal transduction;signal transduction;small GTPase mediated signal transduction 11 10 10 69.1 63.4 63.4 21.308 1.7979E-278 1069600000 559500000 510110000 1365 IPI:IPI00017342.1 Rho-related GTP-binding protein RhoG RHOG;ARHG P84095 ENST00000351018;ENST00000396978;ENST00000396979 K07863 1 0.62509 2.126 1.0306 0.84594 1.3829 1.3783 Ras cell fraction;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;early endosome membrane;endosome membrane;insoluble fraction;melanosome;membrane;membrane fraction;membrane-bounded vesicle;organelle;organelle membrane;plasma membrane;vesicle binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity cell communication;cellular process;establishment of protein localization;intracellular signaling cascade;protein transport;regulation of biological process;signal transduction;small GTPase mediated signal transduction;transport 6 3 3 36.7 21.9 21.9 23.707 3.3761E-148 57274000 31661000 25612000 1366 IPI:IPI00017344.3 Ras-related protein Rab-5B RAB5B P61020 ENST00000360299 K07888 1 0.66688 1.4857 0.67465 0.88319 0.96366 0.88896 Rep_fac-A_3 cell part;chromosomal part;cytoplasm;DNA replication factor A complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear chromosome part;nuclear part;nucleoplasm;organelle part;protein complex binding;DNA binding;nucleic acid binding;single-stranded DNA binding;structure-specific DNA binding DNA catabolic process;DNA metabolic process;DNA replication;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleotide-excision repair, DNA damage removal;nucleotide-excision repair, DNA gap filling DNA replication;Homologous recombination;Mismatch repair;Nucleotide excision repair 6 6 6 66.9 66.9 66.9 13.569 2.6834E-127 153960000 84616000 69341000 1367 IPI:IPI00017373.1 Replication protein A 14 kDa subunit;Replication factor A protein 3 RPA3;REPA3;RPA14 P35244 ENST00000223129;ENST00000396682;ENST00000402771 K10740 1 0.91912 1.7954 0.90655 1.1796 1.1448 1.2063 Gelsolin;Sec23_BS;Sec23_helical;Sec23_trunk;zf-Sec23_Sec24 COPII vesicle coat;cytosol;endoplasmic reticulum membrane;intracellular part;macromolecular complex;membrane;membrane coat;membrane part;organelle membrane;organelle part;protein complex;smooth endoplasmic reticulum membrane;vesicle coat binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding cellular component organization;cellular process;ER to Golgi vesicle-mediated transport;establishment of protein localization;intracellular protein transport;membrane organization;protein transport;transport;vesicle-mediated transport 14 12 12 29.3 26.4 26.4 86.16 0 247790000 128860000 118930000 1368 IPI:IPI00017375.2 Protein transport protein Sec23A;SEC23-related protein A SEC23A Q15436 ENST00000307712 1 0.87687 1.5778 0.88297 1.185 1.1239 1.1358 Gelsolin;Sec23_BS;Sec23_helical;Sec23_trunk;zf-Sec23_Sec24 COPII vesicle coat;endoplasmic reticulum membrane;ER-Golgi intermediate compartment membrane;Golgi apparatus part;intracellular part;macromolecular complex;membrane;membrane coat;membrane part;organelle membrane;organelle part;protein complex;vesicle coat binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding cellular process;ER to Golgi vesicle-mediated transport;establishment of protein localization;Golgi vesicle transport;intracellular protein transport;intracellular transport;protein transport;transport;vesicle-mediated transport 18 18 16 29.1 29.1 26.2 86.478 0 439710000 230620000 209090000 1369 IPI:IPI00017376.2 Protein transport protein Sec23B;SEC23-related protein B SEC23B Q15437 ENST00000262544;ENST00000336714;ENST00000377465;ENST00000377475 1 0.58874 1.1078 0.64995 0.71839 0.77084 0.78254 AAA;Rep_fac_C cell part;chromosomal part;DNA replication factor C complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;protein complex ATP binding;binding;catalytic activity;DNA binding;DNA clamp loader activity;DNA-dependent ATPase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity cell communication;DNA metabolic process;DNA strand elongation during DNA replication;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleotide-excision repair, DNA gap filling;signal transduction DNA replication;Mismatch repair;Nucleotide excision repair 12 12 12 38.8 38.8 38.8 39.681 8.8081E-152 666930000 354290000 312640000 1371 IPI:IPI00017381.1 Replication factor C subunit 4;Activator 1 subunit 4;Replication factor C 37 kDa subunit;Activator 1 37 kDa subunit RFC4 P35249 ENST00000296273;ENST00000392481 K10755 1 0.61921 1.2237 0.61245 0.77572 0.8576 0.77437 AAA;Rep_fac_C cell part;chromosomal part;DNA replication factor C complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;protein complex ATP binding;binding;catalytic activity;DNA binding;DNA clamp loader activity;DNA-dependent ATPase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity biosynthetic process;DNA metabolic process;DNA replication;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleotide-excision repair, DNA gap filling DNA replication;Mismatch repair;Nucleotide excision repair 13 13 13 40.4 40.4 40.4 39.157 5.5773E-217 619900000 344890000 275010000 1372 IPI:IPI00017412.1;IPI:IPI00218280.3;IPI:REV_IPI00783559.1 Replication factor C subunit 2;Activator 1 subunit 2;Replication factor C 40 kDa subunit;Activator 1 40 kDa subunit RFC2 P35250-1;P35250;P35250-2 ENST00000055077;ENST00000352131 K10755 3 0.68886 1.2967 0.73227 0.91679 0.86791 0.9571 Ribosomal_S21e cell part;cytoplasmic part;cytosolic part;cytosolic small ribosomal subunit;intracellular organelle part;intracellular part;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit binding;protein binding;protein N-terminus binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 6 6 6 65.1 65.1 65.1 9.1113 5.2981E-243 2442200000 1284800000 1157500000 1373 IPI:IPI00017448.1 40S ribosomal protein S21 RPS21 P63220 ENST00000317311;ENST00000337102;ENST00000343986 K02971 1 0.79534 1.4029 0.77896 1.1055 0.89037 1.0445 TFIIF_alpha cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex;transcription factor TFIIF complex binding;catalytic activity;DNA binding;nucleic acid binding;protein binding;RNA polymerase II transcription factor activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile Basal transcription factors 11 11 11 26.7 26.7 26.7 58.24 2.2185E-197 277130000 142550000 134580000 1374 IPI:IPI00017450.2 General transcription factor IIF subunit 1;Transcription initiation factor IIF subunit alpha;Transcription initiation factor RAP74;General transcription factor IIF polypeptide 1 74 kDa subunit protein GTF2F1;RAP74 P35269 ENST00000394456 K03138 1 0.77543 1.498 0.79708 1.0433 0.99173 1.0551 Surp;ubiquitin cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex;U2-type spliceosomal complex binding;nucleic acid binding;protein binding;RNA binding anatomical structure formation;cellular component assembly;cellular component organization;cellular process;mRNA splice site selection;nuclear mRNA 3'-splice site recognition;ribonucleoprotein complex assembly 27 27 27 37.5 37.5 37.5 88.885 0 2514000000 1283200000 1230800000 1375 IPI:IPI00017451.1 Splicing factor 3 subunit 1;Spliceosome-associated protein 114;SF3a120 SF3A1;SAP114 Q15459 ENST00000215793 1 1.1736 2.6797 1.2039 1.5963 1.6356 1.573 adh_short cell part;cytoplasm;intracellular part aldo-keto reductase activity;binding;catalytic activity;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;sepiapterin reductase activity biosynthetic process;cellular aromatic compound metabolic process;cellular process;heterocycle biosynthetic process;metabolic process;nitric oxide biosynthetic process;nitrogen compound metabolic process;tetrahydrobiopterin biosynthetic process Folate biosynthesis 11 11 11 50.6 50.6 50.6 28.048 0 285990000 144610000 141380000 1376 IPI:IPI00017469.1;IPI:REV_IPI00290562.4 Sepiapterin reductase SPR P35270 ENST00000234454 K00072 2 0.79748 1.5041 0.79949 0.95908 1.0403 0.9552 COX2;COX2_TM cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part binding;catalytic activity;cation transmembrane transporter activity;copper ion binding;cytochrome-c oxidase activity;electron carrier activity;heme-copper terminal oxidase activity;iron ion binding;transporter activity cellular metabolic process;cellular process;electron transport chain;generation of precursor metabolites and energy;metabolic process;mitochondrial electron transport, cytochrome c to oxygen;respiratory electron transport chain;transport Alzheimer's disease;Cardiac muscle contraction;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 7 7 7 32.2 32.2 32.2 25.565 9.1358E-199 928170000 492570000 435610000 1377 IPI:IPI00017510.3 Cytochrome c oxidase subunit 2;Cytochrome c oxidase polypeptide II MT-CO2;COII;COXII;MTCO2 P00403 ENST00000361739 K02261 1 0.62753 1.574 0.62294 0.83771 0.93635 0.82508 LETM1 cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part binding;calcium ion binding;cation binding;ion binding;metal ion binding;protein binding cellular component organization;cellular process;cristae formation;inner mitochondrial membrane organization;membrane organization;mitochondrial membrane organization;mitochondrion organization;organelle organization 20 20 20 30 30 30 83.353 1.8159E-223 373590000 207030000 166560000 1380 IPI:IPI00017592.1;IPI:IPI00941510.1;IPI:IPI00941879.1 LETM1 and EF-hand domain-containing protein 1, mitochondrial;Leucine zipper-EF-hand-containing transmembrane protein 1 LETM1 O95202-1;O95202 ENST00000302787 3 0.86145 1.7581 0.90269 1.1907 1.0989 1.2473 CH;EB1 cortical cytoskeleton;cortical microtubule cytoskeleton;cytoplasmic part;cytoskeletal part;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle;organelle part binding;cytoskeletal protein binding;microtubule binding;microtubule plus-end binding;protein binding;protein C-terminus binding;tubulin binding cell proliferation;cellular process;mitosis;negative regulation of macromolecule metabolic process;negative regulation of metabolic process;negative regulation of organelle organization;nuclear division;organelle organization 17 17 15 61.6 61.6 61.6 29.999 5.7309E-272 2764400000 1439800000 1324700000 1381 IPI:IPI00017596.3 Microtubule-associated protein RP/EB family member 1;APC-binding protein EB1;End-binding protein 1 MAPRE1 Q15691 ENST00000375571 K10436 1 0.57863 1.0364 0.52408 0.75824 0.68613 0.69514 DEAD;Helicase_C;P68HR intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;ribonucleoprotein complex;spliceosomal complex ATP binding;ATP-dependent helicase activity;binding;catalytic activity;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity;RNA binding;RNA helicase activity cell growth;cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 38 28 28 52 41.9 41.9 69.147 0 6974000000 3773900000 3200100000 1382 IPI:IPI00017617.1 Probable ATP-dependent RNA helicase DDX5;DEAD box protein 5;RNA helicase p68 DDX5;G17P1;HELR;HLR1 P17844 ENST00000225792 1 0.6634 1.355 0.53012 0.86357 0.82832 0.71254 NUFIP1;zf-C2H2 cytosolic ribosome;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nuclear matrix;nucleolus;organelle;perichromatin fibrils;ribonucleoprotein complex;ribosome;transcription elongation factor complex binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;RNA binding;transition metal ion binding;zinc ion binding metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;RNA processing 2 2 2 3.8 3.8 3.8 56.299 3.7261E-13 20438000 11163000 9275000 1383 IPI:IPI00017630.6 Nuclear fragile X mental retardation-interacting protein 1;Nuclear FMRP-interacting protein 1 NUFIP1 Q9UHK0 ENST00000379161 1 0.98441 1.6203 0.85883 1.2473 1.0434 1.2098 RCSD 8 8 8 28.6 28.6 28.6 44.503 2.9593E-112 109470000 54435000 55037000 1384 IPI:IPI00017659.3;IPI:IPI00940120.1 Capz-interacting protein;Protein kinase substrate CapZIP;RCSD domain-containing protein 1 RCSD1;CAPZIP Q6JBY9-1;Q6JBY9;Q6JBY9-2 ENST00000361496;ENST00000367854;ENST00000367856 2 0.66776 1.5207 0.73368 0.91184 0.95038 0.9863 HMG_box chromatin remodeling complex;chromosome;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nuclear chromosome;organelle;SWI/SNF complex;transcriptional repressor complex acyltransferase activity;binding;catalytic activity;chromatin binding;DNA binding;N-acetyltransferase activity;nucleic acid binding;protein binding;transcription coactivator activity;transcription cofactor activity;transcription factor binding chromatin organization;negative regulation of biosynthetic process;nucleosome disassembly;organelle organization;regulation of biosynthetic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent 9 9 9 26 26 26 46.649 7.7956E-94 261970000 138200000 123770000 1385 IPI:IPI00017669.5;IPI:IPI00470489.1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1;BRG1-associated factor 57 SMARCE1;BAF57 Q969G3-1;Q969G3;Q969G3-2 ENST00000348513;ENST00000377808 K11651 2 0.71573 1.3502 0.70726 0.9152 0.91233 0.91234 PNP_UDP_1 cell part;cytoplasmic part;cytosol;intracellular part binding;catalytic activity;drug binding;nucleobase binding;nucleoside binding;purine binding;purine-nucleoside phosphorylase activity;transferase activity;transferase activity, transferring glycosyl groups immune system process;organic acid metabolic process;positive regulation of immune system process;positive regulation of leukocyte activation;regulation of immune system process;regulation of leukocyte activation Nicotinate and nicotinamide metabolism;Purine metabolism;Pyrimidine metabolism 20 20 20 78.5 78.5 78.5 32.551 0 2922400000 1571800000 1350500000 1386 IPI:IPI00017672.4;IPI:IPI00300865.4;IPI:IPI00064917.5 Purine nucleoside phosphorylase;Inosine phosphorylase NP;PNP P00491 ENST00000361505;ENST00000398059 K03783 3 0.79511 1.879 0.87279 1.1582 1.1202 1.1978 Cofilin_ADF cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle actin binding;binding;cytoskeletal protein binding;enzyme binding;protein binding 10 10 10 63.4 63.4 63.4 15.945 9.2094E-137 1632000000 850150000 781830000 1387 IPI:IPI00017704.3 Coactosin-like protein COTL1;CLP Q14019 ENST00000262428 1 0.85116 1.7351 0.82275 1.0753 1.1435 1.0455 adh_short cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;mitochondrion;organelle;plasma membrane 3-hydroxyacyl-CoA dehydrogenase activity;7-alpha-hydroxysteroid dehydrogenase activity;binding;catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;protein binding;steroid dehydrogenase activity cellular process;lipid metabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;tRNA metabolic process;tRNA processing Alzheimer's disease;Valine, leucine and isoleucine degradation 14 14 14 74.3 74.3 74.3 26.923 0 1946700000 1034900000 911830000 1388 IPI:IPI00017726.1;IPI:IPI00336094.5 3-hydroxyacyl-CoA dehydrogenase type-2;3-hydroxyacyl-CoA dehydrogenase type II;Type II HADH;3-hydroxy-2-methylbutyryl-CoA dehydrogenase;17-beta-hydroxysteroid dehydrogenase 10;Mitochondrial ribonuclease P protein 2;Endoplasmic reticulum-associated amyloid beta-peptide-binding protein;Short-chain type dehydrogenase/reductase XH98G2 HSD17B10;ERAB;HADH2;MRPP2;SCHAD;XH98G2 Q99714-1;Q99714;Q99714-2 ENST00000168216;ENST00000375304 K08683 2 0.98857 NaN NaN 1.2524 NaN NaN PB1;Pkinase catalytic activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;receptor signaling protein serine/threonine kinase activity cell communication;intracellular signaling cascade;MAPKKK cascade;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein kinase cascade;protein modification process;signal transduction GnRH signaling pathway;MAPK signaling pathway 3 2 2 5.5 4.1 4.1 74.088 0.0024926 2093500 980320 1113200 1389 IPI:IPI00181703.1;IPI:IPI00017801.3 Mitogen-activated protein kinase kinase kinase 3;MAPK/ERK kinase kinase 3 MAP3K3;MAPKKK3;MEKK3 Q99759-2;Q99759;Q99759-1 ENST00000361357;ENST00000361733 K04421 2 0.64776 1.7514 NaN 0.81589 1.1149 NaN intracellular part;macromolecular complex;membrane;mitochondrial inner membrane;mitochondrial membrane;organelle inner membrane;organelle membrane;organelle part;protein complex;proton-transporting two-sector ATPase complex, proton-transporting domain cation transmembrane transporter activity;hydrogen ion transmembrane transporter activity;ion transmembrane transporter activity;monovalent inorganic cation transmembrane transporter activity;transmembrane transporter activity;transporter activity ATP biosynthetic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;transport 2 2 2 9.3 9.3 9.3 24.882 1.1775E-08 4161300 2365200 1796100 1390 IPI:IPI00017816.2 ATP synthase subunit s, mitochondrial;ATP synthase-coupling factor B;Mitochondrial ATP synthase regulatory component factor B ATP5S;ATPW Q99766 ENST00000311459;ENST00000358473 K07554 1 0.86027 1.7688 0.94076 1.1083 1.1586 1.1875 Aconitase;Aconitase_C cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;mitochondrial matrix;mitochondrial part;nucleus;organelle;organelle part aconitate hydratase activity;binding;carbon-oxygen lyase activity;catalytic activity;cation binding;hydro-lyase activity;ion binding;iron ion binding;iron-sulfur cluster binding;lyase activity;metal ion binding;transition metal ion binding acetyl-CoA metabolic process;carboxylic acid metabolic process;catabolic process;cellular process;citrate metabolic process;coenzyme catabolic process;coenzyme metabolic process;metabolic process;organic acid metabolic process;tricarboxylic acid cycle Citrate cycle (TCA cycle);Glyoxylate and dicarboxylate metabolism;Reductive carboxylate cycle (CO2 fixation) 29 29 29 48.3 48.3 48.3 85.424 0 1809900000 945170000 864760000 1391 IPI:IPI00017855.1 Aconitate hydratase, mitochondrial;Citrate hydro-lyase ACO2 Q99798 ENST00000216254;ENST00000396512 K01681 1 0.65592 1.7312 0.7446 0.93905 1.0856 1.0035 LSM cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;ribonucleoprotein complex;small nuclear ribonucleoprotein complex;spliceosomal complex binding;protein binding anatomical structure formation;cellular component assembly;cellular component organization;cellular process;ribonucleoprotein complex assembly;ribonucleoprotein complex biogenesis;spliceosomal snRNP biogenesis;spliceosome assembly 13 13 13 68.6 68.6 68.6 13.527 8.3732E-227 2321400000 1236900000 1084500000 1394 IPI:IPI00017963.1 Small nuclear ribonucleoprotein Sm D2;snRNP core protein D2 SNRPD2;SNRPD1 P62316 ENST00000342669;ENST00000391932 K11096 1 0.77437 1.3954 0.78003 1.0379 0.95681 1.0193 LSM cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;ribonucleoprotein complex;small nuclear ribonucleoprotein complex;spliceosomal complex binding;enzyme binding;protein binding cellular component biogenesis;cellular process;ribonucleoprotein complex biogenesis;spliceosomal snRNP biogenesis Systemic lupus erythematosus 11 11 11 58.7 58.7 58.7 13.916 3.9359E-211 3351900000 1709800000 1642100000 1395 IPI:IPI00017964.1 Small nuclear ribonucleoprotein Sm D3;snRNP core protein D3 SNRPD3 P62318 ENST00000215829;ENST00000404603 K11088 1 0.66379 0.89677 1.6434 0.8363 0.6364 2.0502 IQ;RIIa cell part;membrane cAMP-dependent protein kinase regulator activity;enzyme regulator activity;kinase regulator activity;protein kinase regulator activity binding of sperm to zona pellucida;cell communication;cell recognition;cell-cell recognition;cellular process;gamete generation;male gamete generation;reproductive process;signal transduction;spermatogenesis;sperm-egg recognition 2 2 2 15.9 15.9 15.9 17.406 1.9079E-43 6764700 2849200 3915500 1396 IPI:IPI00017966.1 Sperm surface protein Sp17;Sperm autoantigenic protein 17;Sp17-1;Cancer/testis antigen 22 SPA17;SP17 Q15506 ENST00000227135 1 0.76112 1.654 0.62616 1.0477 1.0333 0.85024 DFDF;YjeF_N cell part;cytoplasmic mRNA processing body;cytoplasmic part;intracellular part;macromolecular complex;ribonucleoprotein complex binding;protein binding 5 5 5 16.9 16.9 16.9 56.077 9.4882E-49 67356000 35679000 31677000 1397 IPI:IPI00018009.2 Enhancer of mRNA-decapping protein 3;LSM16 homolog;YjeF domain-containing protein 1;YjeF N-terminal domain-containing protein 2 EDC3;LSM16;YJDC;YJEFN2;PP844 Q96F86 ENST00000315127 1 NaN 1.6181 1.0009 NaN 1.0815 1.3764 BSD 3 3 3 11.4 11.4 11.4 51.166 3.1282E-39 13094000 6876500 6217500 1398 IPI:IPI00018026.3;IPI:IPI00414093.2;IPI:IPI00844452.1;IPI:IPI00844524.1;IPI:IPI00844593.1 BSD domain-containing protein 1 BSDC1;UNQ2494/PRO5781 Q9NW68-3;Q9NW68;Q9NW68-1;Q9NW68-2;Q9NW68-5 ENST00000325745;ENST00000341071;ENST00000373520 5 0.64451 1.1813 0.63305 0.79892 0.8459 0.7687 SURF2 5 5 5 20.3 20.3 20.3 29.617 8.2023E-15 80843000 41631000 39212000 1400 IPI:IPI00018037.2 Surfeit locus protein 2 SURF2 Q15527 ENST00000371964 1 0.84663 1.5353 0.8037 1.1119 0.98244 1.0082 SURF5 cell fraction;cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;mediator complex;nuclear part;nucleoplasm part;organelle part;protein complex;soluble fraction binding;general RNA polymerase II transcription factor activity;protein binding;RNA polymerase II transcription factor activity;RNA polymerase II transcription mediator activity;transcription regulator activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 2 2 2 12.5 12.5 12.5 22.22 2.2993E-06 491440000 257180000 234260000 1401 IPI:IPI00018040.1;IPI:IPI00219228.1 Mediator of RNA polymerase II transcription subunit 22;Mediator complex subunit 22;Surfeit locus protein 5 MED22;SURF5 Q15528-1;Q15528;Q15528-2 ENST00000343730;ENST00000344469 2 0.34372 NaN NaN 0.47213 NaN NaN cell part;integral to membrane;intrinsic to membrane;membrane part 2 2 2 1.8 1.8 1.8 134.58 0.00051835 242880 140400 102480 1402 IPI:IPI00018087.5;IPI:IPI00855745.1 Uncharacterized protein C17orf68;HBV DNAPTP1-transactivated protein B C17orf68 Q2NKJ3-1;Q2NKJ3;Q2NKJ3-2 ENST00000315684 2 0.78224 1.787 0.83207 1.004 1.214 1.1108 PRP38 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 6 6 6 13.4 13.4 13.4 64.467 1.6761E-20 98330000 49608000 48722000 1403 IPI:IPI00018098.4;IPI:IPI00647851.2 Pre-mRNA-splicing factor 38B;Sarcoma antigen NY-SAR-27 PRPF38B Q5VTL8-1;Q5VTL8 ENST00000370025 2 0.65321 1.8752 0.71127 1.0538 0.98972 1.1627 apoptosis;cell death;cellular process;death;induction of apoptosis;induction of apoptosis by extracellular signals;induction of programmed cell death;positive regulation of cell death;programmed cell death;regulation of apoptosis;regulation of cell death 2 2 2 33.3 33.3 33.3 11.164 3.2937E-23 23293000 13138000 10156000 1404 IPI:IPI00018117.3 Death-associated protein 1 DAP;DAP1 P51397 ENST00000230895;ENST00000360512 1 0.60888 1.517 0.5701 0.78886 0.98551 0.74129 DAP3 intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;mitochondrial ribosome;non-membrane-bounded organelle;organellar ribosome;organelle;ribonucleoprotein complex;ribosomal subunit;ribosome;small ribosomal subunit binding;protein binding induction of apoptosis;induction of apoptosis by extracellular signals;induction of programmed cell death;positive regulation of apoptosis;positive regulation of cell death;regulation of apoptosis;regulation of cell death 19 19 19 42 42 42 45.566 3.2754E-224 301940000 169500000 132440000 1405 IPI:IPI00018120.1 28S ribosomal protein S29, mitochondrial;MRP-S29;Death-associated protein 3;Ionizing radiation resistance conferring protein DAP3;MRPS29 P51398 ENST00000343043;ENST00000368336 1 0.68457 1.4028 0.70133 0.92637 0.91015 0.9133 RRM_1 cell fraction;endoplasmic reticulum;insoluble fraction;intracellular organelle;macromolecular complex;membrane fraction;membrane-bounded organelle;microsome;nucleoplasm;organelle;ribonucleoprotein complex;spliceosomal complex;vesicular fraction binding;nucleotide binding;protein binding cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 24 17 17 37.1 28.9 28.9 69.602 0 2044800000 1112700000 932070000 1406 IPI:IPI00018140.3;IPI:IPI00402182.2;IPI:IPI00402183.2;IPI:IPI00402184.4;IPI:IPI00402185.5 Heterogeneous nuclear ribonucleoprotein Q;Synaptotagmin-binding, cytoplasmic RNA-interacting protein;Glycine- and tyrosine-rich RNA-binding protein;GRY-RBP;NS1-associated protein 1 SYNCRIP;HNRPQ;NSAP1 O60506-1;O60506;O60506-2;O60506-3;O60506-4;O60506-5 ENST00000355238;ENST00000369622 5 0.7408 1.5118 0.74551 1.0245 0.93681 0.99218 14-3-3 centrosome;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;microtubule organizing center;non-membrane-bounded organelle;nucleus;organelle;organelle part binding;protein binding;protein domain specific binding;protein N-terminus binding negative regulation of biosynthetic process;negative regulation of metabolic process;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of transcription, DNA-dependent Cell cycle 23 21 21 70.2 70.2 70.2 27.764 0 6114200000 3205100000 2909000000 1407 IPI:IPI00018146.1 14-3-3 protein theta;14-3-3 protein tau;14-3-3 protein T-cell;Protein HS1 YWHAQ P27348 ENST00000238081;ENST00000381844 K06630 1 1.4015 2.3965 1.4999 1.8036 1.6186 1.96 DUF1681 cell part;clathrin coat;clathrin vesicle coat;coated pit;cytoplasmic part;cytoplasmic vesicle part;intracellular organelle part;intracellular part;macromolecular complex;membrane coat;membrane part;organelle part;protein complex;vesicle coat cellular component organization;cellular process;endocytosis;establishment of localization;establishment of protein localization;membrane invagination;membrane organization;protein transport;transport;vesicle-mediated transport 3 3 3 19.8 19.8 19.8 28.338 4.497E-72 132630000 62007000 70624000 1408 IPI:IPI00018188.3;IPI:IPI00073436.3;IPI:IPI00386318.3 Adaptin ear-binding coat-associated protein 2;NECAP endocytosis-associated protein 2 NECAP2 Q9NVZ3-1;Q9NVZ3;Q9NVZ3-2;Q9NVZ3-3 ENST00000263498;ENST00000337132;ENST00000406746 3 0.62739 1.2977 0.69355 0.87074 0.84948 0.91159 WD40 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part 6 6 6 23.4 23.4 23.4 42.441 8.6617E-67 62462000 33991000 28471000 1409 IPI:IPI00018192.2;IPI:IPI00165237.3 WD repeat-containing protein 74;NOP seven-associated protein 1 WDR74;NSA1 Q6RFH5-1;Q6RFH5;Q6RFH5-2 ENST00000278856;ENST00000311713 2 0.69531 1.326 0.77649 0.87455 0.91674 0.99497 Pkinase cell part;cytoplasmic part;cytoskeleton;cytosol;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleoplasm;organelle;organelle part catalytic activity;MAP kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;receptor signaling protein serine/threonine kinase activity;signal transducer activity cell communication;cell cycle;intracellular signaling cascade;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;signal transduction;small GTPase mediated signal transduction 22 22 16 50.1 50.1 38.8 43.135 2.4262E-174 2172500000 951270000 1221200000 1410 IPI:IPI00018195.3 Mitogen-activated protein kinase 3;Extracellular signal-regulated kinase 1;Insulin-stimulated MAP2 kinase;MAP kinase 1;p44-ERK1;ERT2;p44-MAPK;Microtubule-associated protein 2 kinase MAPK3;ERK1;PRKM3 P27361 ENST00000263025 1 0.53924 1.0714 0.33833 0.71809 0.75149 0.42615 NLE;WD40 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part 10 10 10 27.4 27.4 27.4 53.266 6.9965E-151 191760000 106360000 85391000 1411 IPI:IPI00018196.5 Notchless protein homolog 1 NLE1;HUSSY-07 Q9NVX2 ENST00000262335;ENST00000360831 1 0.52877 0.95069 0.55269 0.65442 0.62282 0.69422 centrosome;cytoplasmic part;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;microtubule organizing center;non-membrane-bounded organelle;organelle;organelle part 3 3 3 13.6 13.6 13.6 26.933 8.8652E-13 25055000 11941000 13114000 1412 IPI:IPI00018198.3;IPI:IPI00515011.4 HAUS augmin-like complex subunit 2;Centrosomal protein of 27 kDa HAUS2;C15orf25;CEP27 Q9NVX0-1;Q9NVX0;Q9NVX0-2 ENST00000260372 2 0.78773 1.5072 0.76393 1.0251 1.0067 0.98593 Aminotran_1_2 cell part;cytoplasmic part;intracellular organelle part;intracellular part;membrane;mitochondrial matrix;mitochondrial part;organelle part;plasma membrane binding;catalytic activity;L-aspartate:2-oxoglutarate aminotransferase activity;lipid binding;pyridoxal phosphate binding;steroid binding;transaminase activity;transferase activity;transferase activity, transferring nitrogenous groups;vitamin binding aspartate catabolic process;aspartate metabolic process;cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;lipid transport;nitrogen compound metabolic process;organic acid metabolic process;transport Alanine and aspartate metabolism;Alkaloid biosynthesis I;Arginine and proline metabolism;Carbon fixation in photosynthetic organisms;Cysteine metabolism;Glutamate metabolism;Novobiocin biosynthesis;Phenylalanine metabolism;Phenylalanine, tyrosine and tryptophan biosynthesis;Tyrosine metabolism 23 23 23 60.9 60.9 60.9 47.475 0 4519400000 2282600000 2236800000 1413 IPI:IPI00018206.3 Aspartate aminotransferase, mitochondrial;mAspAT;Transaminase A;Glutamate oxaloacetate transaminase 2;Fatty acid-binding protein;FABP-1;FABPpm GOT2 P00505 ENST00000245206 K00813 1 0.91547 1.9668 0.95734 1.2705 1.1986 1.2904 TPR_2 binding 4 4 4 15.3 15.3 15.3 29.411 9.3386E-45 21762000 10878000 10884000 1414 IPI:IPI00018208.2 Tetratricopeptide repeat protein 33;Osmosis-responsive factor TTC33 Q6PID6 ENST00000337702 1 0.79407 1.3627 0.74326 0.99328 0.96288 0.92284 HLH cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;protein binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor activity;transcription factor binding;transcription regulator activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent MAPK signaling pathway;Pathways in cancer;Small cell lung cancer 2 2 2 11.9 11.9 11.9 18.275 7.0927E-08 37587000 21201000 16386000 1415 IPI:IPI00018214.1;IPI:IPI00219929.1;IPI:IPI00158128.1 Protein max;Myc-associated factor X MAX P61244-1;P61244;P61244-2;P61244-3 ENST00000358402;ENST00000358664;ENST00000394606 K04453 3 0.85718 1.7209 0.95744 1.1488 1.1401 1.2138 efhand cell part;cytoplasm;intracellular part;membrane binding;calcium ion binding;cation binding;ion binding;metal ion binding;protein binding;protein dimerization activity;protein heterodimerization activity response to calcium ion;response to chemical stimulus;response to inorganic substance;response to metal ion;response to stimulus 4 4 4 15.5 15.5 15.5 30.381 6.124E-55 145120000 73222000 71903000 1417 IPI:IPI00018235.3 Peflin;PEF protein with a long N-terminal hydrophobic domain;Penta-EF hand domain-containing protein 1 PEF1;ABP32;UNQ1845/PRO3573 Q9UBV8 ENST00000373703 1 0.85907 1.8729 0.7531 1.1314 1.1789 1.0123 NUC130_3NT;SDA1 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;protein binding cellular component biogenesis;cellular process;establishment of localization;establishment of protein localization;protein transport;ribonucleoprotein complex biogenesis;ribosome biogenesis;transport 10 10 10 16.6 16.6 16.6 79.863 2.7197E-266 157930000 82574000 75360000 1418 IPI:IPI00018240.8;IPI:IPI00797421.2 Protein SDA1 homolog;SDA1 domain-containing protein 1;Nucleolar protein 130 SDAD1;NUC130 Q9NVU7-1;Q9NVU7;Q9NVU7-2 ENST00000356260;ENST00000395711 2 0.81819 1.7052 0.80989 1.0518 1.1027 1.0362 Hexokinase_1;Hexokinase_2 cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;membrane;mitochondrial membrane;mitochondrial outer membrane;mitochondrial part;organelle membrane;organelle outer membrane;organelle part;outer membrane ATP binding;binding;catalytic activity;hexokinase activity;kinase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups alcohol metabolic process;carbohydrate metabolic process;catabolic process;cellular process;generation of precursor metabolites and energy;glucose catabolic process;glucose metabolic process;glycolysis;metabolic process;monosaccharide metabolic process Aminosugars metabolism;Fructose and mannose metabolism;Galactose metabolism;Glycolysis / Gluconeogenesis;Insulin signaling pathway;Starch and sucrose metabolism;Streptomycin biosynthesis;Type II diabetes mellitus 28 28 25 34.9 34.9 31.5 102.48 0 926650000 506130000 420520000 1419 IPI:IPI00018246.5;IPI:IPI00220665.6;IPI:IPI00220663.3;IPI:IPI00220667.3;IPI:IPI00414612.3;IPI:IPI00005118.2 Hexokinase-1;Hexokinase type I;Brain form hexokinase HK1 P19367-1;P19367;P19367-3;P19367-2;P19367-4 ENST00000298649;ENST00000356342;ENST00000359426;ENST00000360289;ENST00000404387;ENST00000405407 K00844 6 0.65849 1.2358 0.7035 0.89908 0.80745 0.92875 Arm binding;cation binding;ion binding;metal ion binding cation transport;establishment of localization;ion transport;metal ion transport;transport 6 6 6 21.3 21.3 21.3 31.28 3.4304E-31 75961000 39422000 36539000 1420 IPI:IPI00018260.1 Armadillo repeat-containing protein 1 ARMC1;ARCP Q9NVT9 ENST00000276569 1 0.81588 1.5945 0.84485 1.09 1.0807 1.0979 PNPOx_C;Pyridox_oxidase binding;catalytic activity;FMN binding;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on the CH-NH2 group of donors;pyridoxamine-phosphate oxidase activity;sugar binding biosynthetic process;cellular process;metabolic process;pyridoxine biosynthetic process;pyridoxine metabolic process;vitamin biosynthetic process;vitamin metabolic process;water-soluble vitamin biosynthetic process;water-soluble vitamin metabolic process Vitamin B6 metabolism 7 7 7 29.1 29.1 29.1 29.988 1.5682E-44 319810000 164720000 155090000 1421 IPI:IPI00018272.3 Pyridoxine-5'-phosphate oxidase;Pyridoxamine-phosphate oxidase PNPO Q9NVS9 ENST00000225573 K00275 1 0.75946 1.4172 0.76294 1.034 0.9311 0.97746 Histone cell part;chromosomal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;macromolecular complex;membrane-bounded organelle;nucleosome;nucleus;organelle;organelle part;protein-DNA complex binding;DNA binding;nucleic acid binding anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;chromatin organization;nucleosome assembly;organelle organization Systemic lupus erythematosus 6 4 4 53.9 46.9 46.9 13.553 1.6957E-112 1958600000 1028900000 929740000 1422 IPI:IPI00218448.4;IPI:IPI00018278.3 Histone H2A.Z;Histone H2A.V;H2A.F/Z H2AFZ;H2AZ;H2AFV;H2AV P0C0S5;Q71UI9 ENST00000296417;ENST00000308153 K11251 2 0.27953 0.73534 NaN 0.38346 0.44397 NaN Helicase_C;SNF2_N cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;DNA binding;DNA helicase activity;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity;RNA helicase activity cell cycle process;cellular process;DNA metabolic process;DNA recombination;metabolic process;mitotic recombination;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;reciprocal meiotic recombination Homologous recombination 3 3 3 4.3 4.3 4.3 102.97 2.2536E-14 3665500 2525600 1140000 1423 IPI:IPI00018281.1 DNA repair and recombination protein RAD54B;RAD54 homolog B RAD54B Q9Y620 ENST00000336148 K10877 1 0.61328 1.3274 0.5588 0.83812 0.84953 0.80181 RNA_pol_A_bac;RNA_pol_L cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;catalytic activity;DNA binding;DNA-directed RNA polymerase activity;nucleic acid binding;nucleotidyltransferase activity;protein binding;RNA polymerase activity;transferase activity;transferase activity, transferring phosphorus-containing groups nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile Huntington's disease;RNA polymerase 5 5 5 17.8 17.8 17.8 31.441 4.7444E-28 128940000 72696000 56248000 1424 IPI:IPI00018288.1 DNA-directed RNA polymerase II subunit RPB3;DNA-directed RNA polymerase II subunit C;DNA-directed RNA polymerase II 33 kDa polypeptide;RPB33;RPB31 POLR2C;A-152E5.7 P19387 ENST00000219252 K03011 1 0.71419 1.5295 NaN 0.89751 1.007 NaN cell fraction;cell junction;clathrin coated vesicle membrane;coated vesicle membrane;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle membrane;insoluble fraction;membrane;membrane fraction;secretory granule;synaptosome;vesicle membrane binding;protein binding;SNARE binding cellular process;exocytosis;generation of a signal involved in cell-cell signaling;intracellular protein transport;neurotransmitter secretion;neurotransmitter transport;protein transport;regulation of neurotransmitter levels;transport 3 3 3 33.1 33.1 33.1 14.874 6.7332E-125 11357000 6134600 5222300 1425 IPI:IPI00018331.3 SNARE-associated protein Snapin;Synaptosomal-associated protein 25-binding protein SNAPIN;SNAP25BP;SNAPAP O95295 ENST00000368685 1 0.53012 1.2915 NaN 0.72197 0.85361 NaN ig;I-set;Pkinase_Tyr cell part;extracellular region part;extracellular space;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part catalytic activity;nucleoside binding;nucleotide binding;protein kinase activity;protein tyrosine kinase activity;purine nucleoside binding;receptor activity;signal transducer activity;transmembrane receptor protein tyrosine kinase activity cell communication;cell surface receptor linked signal transduction;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;signal transduction Cytokine-cytokine receptor interaction;Focal adhesion 2 1 1 1.4 0.8 0.8 150.77 1.5032E-06 2635200 1423200 1212000 1426 IPI:IPI00018335.4;IPI:IPI00216043.1 Vascular endothelial growth factor receptor 1;Vascular permeability factor receptor;Tyrosine-protein kinase receptor FLT;Flt-1;Tyrosine-protein kinase FRT;Fms-like tyrosine kinase 1 FLT1;FLT;FRT P17948-1;P17948;P17948-2 ENST00000282397 K05096 2 0.61974 1.2985 0.65001 0.85622 0.83641 0.84822 MCM cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding biosynthetic process;DNA metabolic process;DNA replication initiation;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription Cell cycle;Cell cycle - yeast;DNA replication 40 40 40 52.1 52.1 52.1 96.557 0 5708500000 3024600000 2684000000 1427 IPI:IPI00018349.5;IPI:IPI00032496.2;IPI:IPI00645911.2 DNA replication licensing factor MCM4;CDC21 homolog;P1-CDC21 MCM4;CDC21 P33991 ENST00000262105;ENST00000396826 K02212 3 0.67593 1.2697 0.67731 0.89223 0.84647 0.87904 MCM cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part adenyl nucleotide binding;ATP binding;binding;DNA binding;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding biosynthetic process;DNA metabolic process;DNA replication initiation;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription Cell cycle;Cell cycle - yeast;DNA replication 39 39 39 58.3 58.3 58.3 82.285 0 4030500000 2121300000 1909300000 1428 IPI:IPI00018350.3 DNA replication licensing factor MCM5;CDC46 homolog;P1-CDC46 MCM5;CDC46 P33992 ENST00000216122 K02209 1 0.83456 1.4778 0.77025 1.0994 0.90034 0.96912 BicD cell part;cytoplasmic part;cytoskeleton;Golgi apparatus;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;non-membrane-bounded organelle;organelle binding;protein binding;structural constituent of cytoskeleton;structural molecule activity anatomical structure morphogenesis;cellular process;intracellular mRNA localization;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA localization;RNA processing;transport 5 4 4 6.2 5.4 5.4 110.75 1.5206E-26 22186000 11632000 10554000 1430 IPI:IPI00018368.2;IPI:IPI00337563.2 Protein bicaudal D homolog 1 BICD1 Q96G01-1;Q96G01;Q96G01-3 ENST00000281474 2 0.82962 1.7609 0.79806 1.1425 1.1393 1.0962 AAA cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;proteasome complex;protein complex ATP binding;binding;catalytic activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;transcription coactivator activity;transcription cofactor activity;transcription corepressor activity;transcription factor binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Proteasome 20 20 20 55.4 55.4 55.4 49.203 0 1098600000 575050000 523540000 1431 IPI:IPI00018398.4 26S protease regulatory subunit 6A;Proteasome 26S subunit ATPase 3;TAT-binding protein 1;Proteasome subunit P50 PSMC3;TBP1 P17980 ENST00000298852 K03065 1 0.54955 1.1611 0.61556 0.73846 0.77779 0.80597 CAP_GLY cell part;cytoplasm;cytoskeletal part;intracellular organelle part;intracellular part;microtubule;organelle part binding;chaperone binding;protein binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 20 20 19 46.9 46.9 45.5 59.345 0 692250000 373250000 319000000 1432 IPI:IPI00018402.1 Tubulin-specific chaperone E;Tubulin-folding cofactor E TBCE Q15813 ENST00000366601;ENST00000406207 1 1.0187 1.9421 0.96671 1.3604 1.3356 1.1952 EMP70 cytoplasmic part;endosomal part;endosome membrane;integral to membrane;integral to plasma membrane;intracellular organelle part;intracellular part;intrinsic to membrane;intrinsic to plasma membrane;membrane;membrane part;organelle membrane;organelle part establishment of localization;transport 6 6 6 11.2 11.2 11.2 75.775 2.1956E-158 183280000 91611000 91664000 1433 IPI:IPI00018415.1 Transmembrane 9 superfamily member 2;p76 TM9SF2 Q99805 ENST00000376387 1 0.90687 1.4879 1.0466 1.1538 0.94564 1.3614 UEV;Vps23_core endosome;endosome membrane;intracellular organelle;late endosome;late endosome membrane;membrane;membrane-bounded organelle;multivesicular body;non-membrane-bounded organelle;nucleolus;organelle;organelle membrane;plasma membrane binding;catalytic activity;DNA binding;ligase activity;nucleic acid binding;protein binding;transcription cofactor activity;transcription corepressor activity;transcription factor binding;transcription repressor activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;protein modification process;protein transport;proteolysis;release of virus from host;transport;ubiquitin-dependent protein catabolic process 8 8 8 21 21 21 43.944 8.9349E-57 166020000 86843000 79180000 1434 IPI:IPI00018434.1;IPI:IPI00219826.1 Tumor susceptibility gene 101 protein;ESCRT-I complex subunit TSG101 TSG101 Q99816-1;Q99816;Q99816-2 ENST00000251968;ENST00000357193 K12183 2 0.55873 0.92097 0.54893 0.70949 0.64749 0.70243 C2;Copine binding;calcium-dependent phospholipid binding;lipid binding;phosphatidylserine binding;phospholipid binding;transporter activity cellular process;establishment of localization;lipid metabolic process;metabolic process;primary metabolic process;transport;vesicle-mediated transport 10 10 10 17.5 17.5 17.5 59.058 3.9354E-94 203620000 112030000 91590000 1436 IPI:IPI00018452.3 Copine-1;Copine I CPNE1;CPN1 Q99829 ENST00000317619;ENST00000317677;ENST00000352393;ENST00000374114;ENST00000397443;ENST00000397445;ENST00000397446;ENST00000401607;ENST00000402424 1 0.92885 1.6801 0.91005 1.1929 1.1277 1.1845 Cpn60_TCP1 cell part;cytoplasm;intracellular part adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 46 46 46 83.2 83.2 83.2 59.366 0 12416000000 6435900000 5979600000 1437 IPI:IPI00018465.1 T-complex protein 1 subunit eta;CCT-eta;HIV-1 Nef-interacting protein CCT7;CCTH;NIP7-1 Q99832 ENST00000409924 K09499 1 0.66616 1.3026 NaN 0.84306 0.79664 NaN ARID cell part;cytoplasmic part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;transcription factor activity;transcription regulator activity biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 4 4 4 6.7 6.7 6.7 62.888 2.3836E-14 6494300 2660100 3834200 1438 IPI:IPI00018500.1 AT-rich interactive domain-containing protein 3A;ARID domain-containing protein 3A;Dead ringer-like protein 1;B-cell regulator of IgH transcription;E2F-binding protein 1 ARID3A;DRIL1;DRIL3;DRX;E2FBP1 Q99856 ENST00000263620 1 0.62476 1.2398 0.59499 0.84325 0.77929 0.80235 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;methyltransferase activity;N-methyltransferase activity;protein binding;transferase activity;transferase activity, transferring one-carbon groups cell communication;cell surface receptor linked signal transduction;cellular process;metabolic process;one-carbon metabolic process;protein amino acid alkylation;protein amino acid methylation;protein modification process;signal transduction 21 21 21 55.3 55.3 55.3 42.461 0 2744700000 1610500000 1134100000 1439 IPI:IPI00018522.4;IPI:IPI00215734.3;IPI:IPI00914913.1;IPI:IPI00549813.3;IPI:IPI00747005.3 Protein arginine N-methyltransferase 1;Interferon receptor 1-bound protein 4 PRMT1;HMT2;HRMT1L2;IR1B4 Q99873-1;Q99873;Q99873-2;Q99873-3 ENST00000351853;ENST00000391849;ENST00000391851;ENST00000408976 K11434 5 0.62669 1.0058 NaN 0.83678 0.65598 NaN Pkinase_Tyr;SH2 cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane part;membrane-bounded organelle;nucleus;organelle;plasma membrane part;protein complex;receptor complex;T cell receptor complex binding;catalytic activity;integrin binding;non-membrane spanning protein tyrosine kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein tyrosine kinase activity;purine nucleoside binding;receptor binding behavior;cell adhesion;cell communication;cell motion;cell surface receptor linked signal transduction;chemotaxis;immune system process;integrin-mediated signaling pathway;leukocyte adhesion;locomotory behavior;protein complex assembly;signal transduction 10 9 9 19.8 18.6 18.6 72.065 1.9497E-64 22968000 12435000 10533000 1440 IPI:IPI00018597.1;IPI:IPI00218278.1 Tyrosine-protein kinase SYK;Spleen tyrosine kinase SYK P43405-1;P43405;P43405-2 ENST00000375746;ENST00000375751;ENST00000375754 2 0.71143 1.424 0.73812 0.96068 0.94095 0.97693 Acetyltransf_1 cell part;cytoplasm;intracellular part acetyltransferase activity;acyltransferase activity;binding;catalytic activity;N-acetyltransferase activity;N-acyltransferase activity;protein binding;transferase activity;transferase activity, transferring acyl groups cellular process;metabolic process;N-terminal protein amino acid acetylation;peptide or protein amino-terminal blocking;peptidyl-amino acid modification;protein amino acid acetylation;protein metabolic process;protein modification process 14 14 14 69.8 69.8 69.8 19.398 1.0707E-154 912590000 670540000 242040000 1441 IPI:IPI00018627.3;IPI:IPI00470922.2 N-acetyltransferase 13;N-acetyltransferase 5;N-acetyltransferase san homolog NAT13;MAK3;NAT5 Q9GZZ1-1;Q9GZZ1;Q9GZZ1-2 ENST00000240922;ENST00000313396 2 1.1015 1.7934 0.89801 1.3333 1.2125 1.0896 DSPc cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;phosphatase activity;phosphoprotein phosphatase activity;phosphoric ester hydrolase activity;protein tyrosine phosphatase activity cellular biopolymer metabolic process;cellular process;dephosphorylation;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid dephosphorylation;protein metabolic process;protein modification process MAPK signaling pathway 3 3 3 21.1 21.1 21.1 20.478 9.8404E-93 61700000 32451000 29248000 1442 IPI:IPI00018671.1 Dual specificity protein phosphatase 3;Dual specificity protein phosphatase VHR DUSP3;VHR P51452 ENST00000226004 K04459 1 NaN 1.5729 0.77728 NaN 1.1124 0.96976 Ribosomal_S18 cytoplasmic part;intracellular part;macromolecular complex;mitochondrial part;mitochondrial small ribosomal subunit;organellar small ribosomal subunit;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 3 3 3 16.8 16.8 16.8 22.184 6.1518E-35 22982000 12403000 10579000 1443 IPI:IPI00018691.1 28S ribosomal protein S18a, mitochondrial;MRP-S18-a;MRP-S18-3 MRPS18A Q9NVS2 ENST00000372118;ENST00000372133 1 0.72972 2.1058 0.69663 1.0198 1.2827 0.98054 centrosome;cytoplasmic part;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;microtubule organizing center;non-membrane-bounded organelle;organelle;organelle part binding;protein binding 2 2 2 3.8 3.8 3.8 81.343 4.2292E-05 6817100 3516400 3300800 1445 IPI:IPI00043373.1;IPI:IPI00018708.1;IPI:IPI00060568.3;IPI:IPI00041779.2 Centrosomal protein of 63 kDa CEP63 Q96MT8-1;Q96MT8;Q96MT8-2;Q96MT8-3;Q96MT8-4 ENST00000332047;ENST00000337090;ENST00000354446;ENST00000383229 4 0.84287 1.7051 0.83188 1.0919 1.0801 1.0839 Translin cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;sequence-specific DNA binding cellular biopolymer metabolic process;cellular process;DNA metabolic process;DNA recombination;macromolecule metabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 15 15 15 57 57 57 26.183 5.1797E-221 1001400000 529060000 472370000 1447 IPI:IPI00018768.1 Translin TSN Q15631 ENST00000389682 1 0.71735 1.6164 0.79909 1.0396 0.96648 1.0512 Ham1p_like cell part;cytoplasm;intracellular part binding;catalytic activity;cation binding;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;ion binding;magnesium ion binding;pyrophosphatase activity cellular metabolic process;cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;nucleotide metabolic process Drug metabolism - other enzymes;Purine metabolism;Pyrimidine metabolism 7 7 7 50 50 50 21.445 2.6014E-134 95400000 50257000 45143000 1448 IPI:IPI00018783.1 Inosine triphosphate pyrophosphatase;Putative oncogene protein hlc14-06-p ITPA;C20orf37;My049;OK/SW-cl.9 Q9BY32 ENST00000380113 K01519 1 0.85744 1.5462 0.91955 1.0674 1.085 1.1371 binding;protein binding 3 3 3 5.5 5.5 5.5 79.135 2.0597E-09 46746000 25155000 21591000 1449 IPI:IPI00018786.1;IPI:IPI00855958.1;IPI:IPI00855990.1 WD repeat-containing protein C2orf44 C2orf44;PP384 Q9H6R7-1;Q9H6R7;Q9H6R7-2 ENST00000295148 3 0.86451 1.3101 1.1211 1.1091 0.8473 1.4518 DnaJ binding;heat shock protein binding;nucleic acid binding;protein binding;RNA binding;unfolded protein binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 3 3 3 13.5 13.5 13.5 34.687 5.3905E-14 25744000 11401000 14343000 1450 IPI:IPI00018798.3 DnaJ homolog subfamily C member 17 DNAJC17 Q9NVM6 ENST00000220496 K09537 1 0.74143 1.5708 0.71529 0.99347 1.0325 0.95707 PCI cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex;signalosome binding;molecular transducer activity;protein binding;signal transducer activity cell communication;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;signal transduction;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent 18 18 18 42.7 42.7 42.7 52.404 2.9441E-116 396490000 216420000 180070000 1451 IPI:IPI00018813.5;IPI:IPI00743825.1 COP9 signalosome complex subunit 2;JAB1-containing signalosome subunit 2;Thyroid receptor-interacting protein 15;Alien homolog COPS2;CSN2;TRIP15 P61201-2;P61201;P61201-1 ENST00000299259;ENST00000388901 K12176 2 NaN 0.54744 NaN NaN 0.3881 NaN CH;PH;Spectrin cell cortex part;cell part;cytoplasmic part;cytoskeletal part;intracellular organelle part;intracellular part;nuclear body;nuclear matrix;nuclear part;nucleoplasm part;organelle part;PML body;spectrin actin binding;ankyrin binding;binding;cytoskeletal protein binding;protein binding;structural constituent of cytoskeleton;structural molecule activity cellular process;cytoskeletal anchoring at plasma membrane;cytoskeleton organization;negative regulation of metabolic process;organelle organization;regulation of actin polymerization or depolymerization;transport 4 1 1 1.6 0.5 0.5 288.98 1.0619E-11 68744000 34490000 34254000 1452 IPI:IPI00018829.2;IPI:IPI00217047.4;IPI:IPI00217048.1;IPI:IPI00217044.1 Spectrin beta chain, brain 3;Spectrin, non-erythroid beta chain 3;Beta-IV spectrin SPTBN4;KIAA1642;SPTBN3 Q9H254-1;Q9H254;Q9H254-3;Q9H254-4;Q9H254-2 ENST00000338932;ENST00000344104;ENST00000352632;ENST00000392025 K06115 4 1.1915 2.5731 1.1867 1.5884 1.7007 1.5928 MHC_I anchored to membrane;cell part;cell surface;extracellular region part;extracellular space;intrinsic to membrane;macromolecular complex;membrane part;MHC class I protein complex;MHC protein complex;plasma membrane part;protein complex MHC class I receptor activity;molecular transducer activity;receptor activity;signal transducer activity;transmembrane receptor activity antigen processing and presentation;cell activation;cellular process;immune response;immune system process;leukocyte activation;lymphocyte activation;natural killer cell activation;response to stimulus Natural killer cell mediated cytotoxicity 3 3 3 16.3 16.3 16.3 27.368 1.1698E-23 19107000 9562700 9544600 1455 IPI:IPI00018860.1;IPI:IPI00152655.2;IPI:IPI00433027.1;IPI:IPI00477175.4 NKG2D ligand 2;UL16-binding protein 2;NKG2DL2;ALCAN-alpha;Retinoic acid early transcript 1H;Retinoic acid early transcript 1L protein ULBP2;N2DL2;RAET1H;UNQ463/PRO791;RAET1L Q9BZM5;Q5VY80 ENST00000367351;ENST00000286380;ENST00000367341 K07986;K07987 4 0.73425 1.4004 0.71633 0.98705 0.89413 0.971 NAPRTase cell part;cytoplasmic part;cytosol;intracellular part binding;catalytic activity;cytokine activity;nicotinamide phosphoribosyltransferase activity;protein binding;receptor binding;transferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring pentosyl groups cell communication;cell-cell signaling;cellular process;positive regulation of biological process;positive regulation of cell proliferation;positive regulation of cellular process;regulation of cell proliferation;signal transduction Nicotinate and nicotinamide metabolism 18 18 18 51.5 51.5 51.5 55.52 0 1176500000 630490000 546000000 1456 IPI:IPI00018873.1 Nicotinamide phosphoribosyltransferase;Pre-B-cell colony-enhancing factor 1;Visfatin NAMPT;PBEF;PBEF1 P43490 ENST00000222553 K03462 1 NaN 1.6105 0.82463 NaN 0.95931 1.0316 zf-C2H2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;transcription factor activity;transcription regulator activity;transition metal ion binding;zinc ion binding mesoderm development;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 3 2 2 9.2 5.3 5.3 58.023 1.8431E-22 8533300 4188200 4345100 1458 IPI:IPI00018923.2;IPI:IPI00215853.2;IPI:IPI00215854.2;IPI:IPI00215856.2;IPI:IPI00215852.2;IPI:IPI00215855.2 Zinc finger protein Aiolos;Ikaros family zinc finger protein 3 IKZF3;ZNFN1A3 Q9UKT9-1;Q9UKT9;Q9UKT9-3;Q9UKT9-4;Q9UKT9-6;Q9UKT9-2;Q9UKT9-5 ENST00000293068;ENST00000346243;ENST00000346872;ENST00000348427;ENST00000350532;ENST00000351680 K09220 6 0.89645 1.4061 0.99013 1.181 0.98845 1.2147 HMG_box cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;protein binding;transcription factor activity;transcription regulator activity biosynthetic process;chromatin organization;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;regulation of transcription, DNA-dependent;transcription 5 5 5 20.5 20.5 20.5 40.143 4.3091E-53 61205000 30768000 30437000 1459 IPI:IPI00018924.3 High mobility group protein 20A;HMG box-containing protein 20A;HMG domain-containing protein HMGX1;HMG domain-containing protein 1 HMG20A;HMGX1;HMGXB1 Q9NP66-1;Q9NP66 ENST00000336216;ENST00000381714 1 0.85522 1.5773 0.81719 1.0863 1.0407 1.0546 Vps35 cell part;cytoplasmic part;cytosol;endosome;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;organelle binding;protein binding cellular process;endosome transport;establishment of localization;establishment of protein localization;intracellular transport;protein transport;retrograde transport, endosome to Golgi;transport;vesicle-mediated transport 26 26 26 37.3 37.3 37.3 91.706 0 1927000000 913790000 1013200000 1460 IPI:IPI00018931.6 Vacuolar protein sorting-associated protein 35;Vesicle protein sorting 35;Maternal-embryonic 3 VPS35;MEM3;TCCCTA00141 Q96QK1 ENST00000299138 1 0.61898 1.3501 0.62193 0.85766 0.85327 0.80685 ThiF cell fraction;cell part;cytoplasm;insoluble fraction;intracellular part;membrane;plasma membrane binding;catalytic activity;protein binding;protein dimerization activity;protein heterodimerization activity apoptosis;cell cycle checkpoint;DNA damage checkpoint;DNA metabolic process;DNA replication;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein modification process;proteolysis Alzheimer's disease 19 19 19 47.6 47.6 47.6 60.246 0 428830000 240980000 187850000 1461 IPI:IPI00018968.2 NEDD8-activating enzyme E1 regulatory subunit;Amyloid protein-binding protein 1;Amyloid beta precursor protein-binding protein 1, 59 kDa;Proto-oncogene protein 1 NAE1;APPBP1;HPP1 Q13564 ENST00000290810;ENST00000359087 K04532 1 NaN 0.73579 NaN NaN 0.52236 NaN SPRY;zf-B_box;zf-C3HC4 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;ribonucleoprotein complex binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;RNA binding;transition metal ion binding;zinc ion binding anatomical structure formation;cellular component assembly;cellular component organization;macromolecular complex assembly;macromolecular complex subunit organization;protein complex assembly;protein oligomerization;protein trimerization Systemic lupus erythematosus 2 2 2 5.7 5.7 5.7 54.169 6.3313E-07 12857000 6635500 6221000 1462 IPI:IPI00018971.8 52 kDa Ro protein;Sjoegren syndrome type A antigen;Ro(SS-A);52 kDa ribonucleoprotein autoantigen Ro/SS-A;Tripartite motif-containing protein 21;RING finger protein 81 TRIM21;RNF81;RO52;SSA1 P19474 ENST00000254436 K10651 1 0.77145 2.1418 0.88033 1.0413 1.3738 1.2012 Sec62 cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part molecular transducer activity;protein transporter activity;receptor activity;signal transducer activity;substrate-specific transporter activity;transporter activity cellular process;cotranslational protein targeting to membrane;establishment of protein localization;intracellular protein transport;intracellular transport;protein targeting;protein targeting to membrane;protein transport;transport 4 4 4 9 9 9 45.861 7.6063E-15 120790000 61005000 59789000 1463 IPI:IPI00019004.1 Translocation protein SEC62;Translocation protein 1 SEC62;TLOC1 Q99442 ENST00000337002 K12275 1 0.61662 1.2962 0.52491 0.8468 0.88317 0.71903 ABC_membrane;ABC_tran cell fraction;insoluble fraction;integral to membrane;intrinsic to membrane;macromolecular complex;membrane;membrane fraction;mitochondrial inner membrane;mitochondrial membrane;organelle inner membrane;organelle membrane ATP binding;binding;catalytic activity;nucleoside binding;nucleotide binding;P-P-bond-hydrolysis-driven transmembrane transporter activity;primary active transmembrane transporter activity;purine nucleoside binding;transporter activity establishment of localization;transport ABC transporters 5 5 5 6.9 6.9 6.9 79.988 1.8923E-29 14489000 8252300 6236600 1464 IPI:IPI00019022.2;IPI:IPI00719730.2 ATP-binding cassette sub-family B member 8, mitochondrial;Mitochondrial ATP-binding cassette 1 ABCB8;MABC1 Q9NUT2-1;Q9NUT2;Q9NUT2-2 ENST00000297504;ENST00000358849 K05655 2 NaN 10.081 0.023758 NaN 7.1184 0.029395 Lys extracellular region part;extracellular space binding;catalytic activity;hydrolase activity;hydrolase activity, acting on glycosyl bonds;hydrolase activity, hydrolyzing O-glycosyl compounds;lysozyme activity;protein binding catabolic process;cell death;cellular process;death;defense response;inflammatory response;metabolic process;response to bacterium;response to biotic stimulus;response to external stimulus;response to stress;response to wounding 4 4 4 25.7 25.7 25.7 16.537 7.7153E-50 69162000 63472000 5690000 1465 IPI:IPI00019038.1 Lysozyme C;1,4-beta-N-acetylmuramidase C LYZ;LZM P61626 ENST00000261267 K01185 1 0.94174 1.518 0.93293 1.1804 1.0757 1.108 RRM_1;zf-CCCH cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;calcium-dependent protein binding;cation binding;ion binding;metal ion binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding;transition metal ion binding;zinc ion binding intracellular protein transport;metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein import into nucleus, translocation;RNA processing;RNA splicing;transport 8 8 8 22.4 22.4 22.4 46.895 2.6835E-88 234980000 116400000 118570000 1466 IPI:IPI00019046.4;IPI:IPI00909290.1 Pre-mRNA-splicing factor RBM22;RNA-binding motif protein 22;Zinc finger CCCH domain-containing protein 16 RBM22;ZC3H16;199G4 Q9NW64-1;Q9NW64;Q9NW64-2 ENST00000199814 2 0.8257 1.5056 0.86506 1.0665 1.0124 1.0444 TAP42 cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle binding;enzyme regulator activity;phosphatase regulator activity;protein binding;protein phosphatase regulator activity;protein phosphatase type 2A regulator activity B cell activation;cell activation;cell communication;cellular process;immune system process;leukocyte activation;lymphocyte activation;regulation of cell communication;regulation of signal transduction;response to biotic stimulus;signal transduction 10 10 10 35.7 35.7 35.7 39.221 2.7408E-41 121490000 61771000 59721000 1467 IPI:IPI00019148.1 Immunoglobulin-binding protein 1;CD79a-binding protein 1;B-cell signal transduction molecule alpha 4;Renal carcinoma antigen NY-REN-16 IGBP1;IBP1 P78318 ENST00000342206;ENST00000356413 1 0.70256 1.7525 0.7836 0.85616 1.1371 1.0817 BAR;SH3_1 cell part;cytoplasmic part;cytosol;intracellular part;membrane;plasma membrane binding;identical protein binding;lipid binding;protein binding cell communication;cellular component organization;cellular process;central nervous system development;developmental process;endocytosis;membrane invagination;membrane organization;signal transduction;transport;vesicle-mediated transport 5 5 5 11.1 11.1 11.1 39.962 3.5664E-13 62397000 33202000 29195000 1468 IPI:IPI00019171.1 Endophilin-A1;Endophilin-1;SH3 domain-containing GRB2-like protein 2;SH3 domain protein 2A;EEN-B1 SH3GL2;CNSA2;SH3D2A Q99962 ENST00000380607 K11247 1 0.95942 1.4556 0.93368 1.1614 1.0726 1.1355 Hydrolase binding;catalytic activity;cation binding;hydrolase activity;hydrolase activity, acting on ester bonds;ion binding;magnesium ion binding;phosphatase activity;phosphoric ester hydrolase activity;phosphoserine phosphatase activity;protein binding cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;L-serine biosynthetic process;L-serine metabolic process;metabolic process;nitrogen compound metabolic process;organic acid metabolic process Glycine, serine and threonine metabolism 5 5 5 24 24 24 25.007 2.1822E-32 233170000 119680000 113490000 1469 IPI:IPI00019178.2 Phosphoserine phosphatase;O-phosphoserine phosphohydrolase;L-3-phosphoserine phosphatase PSPH P78330 ENST00000275605;ENST00000395471 K01079 1 0.55798 1.2385 0.42898 0.69804 0.86489 0.52909 Ribosomal_L7Ae cell part;intracellular organelle part;intracellular part;macromolecular complex;multimeric ribonuclease P complex;nuclear part;nucleolar part;nucleolar ribonuclease P complex;organelle part;ribonuclease P complex;ribonucleoprotein complex binding;catalytic activity;endonuclease activity;endoribonuclease activity;hydrolase activity;hydrolase activity, acting on ester bonds;nuclease activity;protein binding;ribonuclease activity;ribonuclease P activity;tRNA-specific ribonuclease activity cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;tRNA metabolic process;tRNA processing 7 7 7 25.4 25.4 25.4 31.834 5.7277E-15 7831700 4331500 3500200 1470 IPI:IPI00019195.2 Ribonuclease P protein subunit p38 RPP38 P78345 ENST00000378197;ENST00000378202;ENST00000378203 K01164 1 0.60975 1.5286 0.54945 0.83497 1.0264 0.73011 RNase_P_p30 cell part;intracellular organelle part;intracellular part;macromolecular complex;multimeric ribonuclease P complex;nuclear part;nucleolar part;nucleolar ribonuclease P complex;organelle part;ribonuclease P complex;ribonucleoprotein complex binding;catalytic activity;endonuclease activity;endoribonuclease activity;hydrolase activity;hydrolase activity, acting on ester bonds;nuclease activity;protein binding;ribonuclease activity;ribonuclease P activity;tRNA-specific ribonuclease activity cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;tRNA metabolic process;tRNA processing 8 8 8 33.2 33.2 33.2 29.321 2.925E-46 120200000 66638000 53565000 1471 IPI:IPI00019196.3 Ribonuclease P protein subunit p30;RNase P subunit 2 RPP30;RNASEP2 P78346 ENST00000277882;ENST00000371703 K03539 1 0.86898 1.6491 1.0628 1.1012 1.092 1.2969 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 5 3 3 8.3 5 5 82.658 2.7226E-69 11444000 6222700 5221300 1472 IPI:IPI00019205.1 Enhanced at puberty protein 1 EAP1;C14orf4;KIAA1865;My039 Q9H1B7 ENST00000238647 1 0.69214 1.4405 0.59305 1.0131 0.88366 0.85138 PACT_coil_coil centrosome;Golgi apparatus;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;microtubule organizing center;non-membrane-bounded organelle;organelle;organelle part binding;protein binding;receptor binding biological regulation;cell communication;cell-cell signaling;cellular process;establishment of localization;regulation of biological process;regulation of cellular process;signal transduction;synaptic transmission;transport 16 16 16 5.1 5.1 5.1 455.42 3.1407E-34 145870000 81775000 64098000 1473 IPI:IPI00220628.1;IPI:IPI00019223.3;IPI:IPI00220624.2;IPI:IPI00220625.1;IPI:IPI00220627.1;IPI:IPI00793082.2 A-kinase anchor protein 9;Protein kinase A-anchoring protein 9;A-kinase anchor protein 450 kDa;A-kinase anchor protein 350 kDa;AKAP 120-like protein;Protein hyperion;Protein yotiao;Centrosome- and Golgi-localized PKN-associated protein AKAP9;AKAP350;AKAP450;KIAA0803 Q99996-6;Q99996;Q99996-1;Q99996-2;Q99996-3;Q99996-5 ENST00000356239;ENST00000358100;ENST00000359028 6 0.86989 1.5862 0.8623 1.1502 1.0633 1.084 WD40 12 12 12 52.8 52.8 52.8 33.58 0 375480000 197310000 178170000 1474 IPI:IPI00019269.3 WD repeat-containing protein 61;Meiotic recombination REC14 protein homolog WDR61 Q9GZS3 ENST00000267973 1 0.73457 1.613 0.95225 0.96681 1.0209 1.1923 PUB;UBX centrosome;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;microtubule organizing center;non-membrane-bounded organelle;nucleus;organelle;organelle part binding;protein binding catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 5 5 5 15.4 15.4 15.4 49.753 1.6594E-39 19450000 10377000 9072700 1475 IPI:IPI00019276.1;IPI:IPI00163100.1 UBX domain-containing protein 6;UBX domain-containing protein 1 UBXN6;UBXD1;UBXDC2 Q9BZV1-1;Q9BZV1;Q9BZV1-2 ENST00000301281;ENST00000394765 2 0.62885 3.814 NaN 0.83004 2.4994 NaN binding;protein binding 4 4 4 11.2 11.2 11.2 57.889 3.8341E-15 9900400 5054900 4845500 1476 IPI:IPI00019282.1 Melanoma antigen preferentially expressed in tumors;Preferentially expressed antigen of melanoma;OPA-interacting protein 4 PRAME;MAPE P78395 ENST00000358617;ENST00000398741;ENST00000398743;ENST00000402697;ENST00000405655 1 0.75844 1.5318 NaN 1.1211 0.87872 NaN Ras cell part;cytoplasmic part;cytosol;intracellular part;membrane;plasma membrane binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleotide binding;pyrophosphatase activity biological regulation;cell cycle;cellular process;negative regulation of biological process;negative regulation of cell cycle;negative regulation of cellular process;regulation of biological process;regulation of cell cycle;regulation of cellular process Chemokine signaling pathway;Focal adhesion;Leukocyte transendothelial migration;Long-term potentiation;MAPK signaling pathway;Renal cell carcinoma 8 2 2 40.8 15.2 15.2 20.987 7.2664E-111 59839000 32505000 27334000 1479 IPI:IPI00019345.1 Ras-related protein Rap-1A;GTP-binding protein smg-p21A;Ras-related protein Krev-1;C21KG;G-22K RAP1A;KREV1 P62834 ENST00000356415;ENST00000369709 K04353 1 0.78268 1.5644 0.74355 1.0308 1.0629 1.0031 DAGK_cat cell part;cytoplasmic part;intracellular organelle part;intracellular part;membrane;mitochondrial membrane;mitochondrial part;organelle membrane;organelle part ATP binding;binding;catalytic activity;diacylglycerol kinase activity;kinase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway;cell communication;cell surface receptor linked signal transduction;cellular process;G-protein coupled receptor protein signaling pathway;signal transduction Glycerolipid metabolism 10 10 10 32.2 32.2 32.2 47.137 4.0226E-130 98334000 55850000 42483000 1480 IPI:IPI00019353.4 Acylglycerol kinase, mitochondrial;Multiple substrate lipid kinase AGK;MULK Q53H12-1;Q53H12 ENST00000355413 K09881 1 0.039209 43.613 0.018211 0.05501 25.812 0.027352 Filament cell part;cytoplasm;cytoskeletal part;intermediate filament;intracellular organelle part;intracellular part;organelle part binding;protein binding;structural constituent of cytoskeleton;structural molecule activity cellular component organization;cellular process;cytoskeleton organization;developmental process;epidermis development;intermediate filament-based process;organelle organization;skin development;tissue development + 38 38 38 72.6 72.6 72.6 62.064 0 12074000000 11874000000 199980000 1481 IPI:IPI00019359.4;IPI:CON_00019359.3 Keratin, type I cytoskeletal 9;Cytokeratin-9;Keratin-9 KRT9 P35527 ENST00000246662 K07604 2 0.69332 1.4232 0.71912 0.91733 0.93959 0.93322 MIF4G;MIF4G_like;MIF4G_like_2 cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;mRNA cap binding complex;nuclear part;nucleoplasm;organelle part;protein complex;RNA cap binding complex binding;nucleic acid binding;protein binding;RNA binding;RNA cap binding metabolic process;mRNA cleavage;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;positive regulation of metabolic process;RNA processing;spliceosomal snRNP biogenesis;transport 19 19 19 31.9 31.9 31.9 91.838 0 727900000 400130000 327770000 1482 IPI:IPI00019380.1 Nuclear cap-binding protein subunit 1;80 kDa nuclear cap-binding protein;NCBP 80 kDa subunit NCBP1;CBP80;NCBP Q09161 ENST00000375147 1 0.86422 1.7687 0.76935 1.1556 1.2412 0.98231 CDC50 cell part;integral to membrane;intrinsic to membrane;membrane part 4 4 4 15 15 15 40.683 5.7759E-17 31817000 17217000 14599000 1483 IPI:IPI00019381.4;IPI:IPI00062679.4;IPI:IPI00760748.1 Cell cycle control protein 50A;Transmembrane protein 30A TMEM30A;C6orf67;CDC50A Q9NV96-1;Q9NV96;Q9NV96-2;Q9NV96-3 ENST00000230461;ENST00000370050 3 0.88219 1.535 0.8771 1.1453 0.9894 1.139 TRAP-delta cell part;cytoplasmic part;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;macromolecular complex;membrane part;organelle part;protein complex;translocon complex binding;calcium ion binding;cation binding;ion binding;metal ion binding;protein binding establishment of localization;establishment of localization in cell;establishment of protein localization;intracellular protein transport;intracellular transport;protein transport;transport 6 6 6 30.4 30.4 30.4 20.213 3.4215E-101 794600000 396350000 398250000 1484 IPI:IPI00019385.3 Translocon-associated protein subunit delta;Signal sequence receptor subunit delta SSR4;TRAPD P51571 ENST00000320857;ENST00000370086;ENST00000370087 K04571 1 0.81045 1.4764 0.77415 1.0908 0.94213 1.014 TPMT catalytic activity;methyltransferase activity;S-adenosylmethionine-dependent methyltransferase activity;S-methyltransferase activity;thiopurine S-methyltransferase activity;transferase activity;transferase activity, transferring one-carbon groups cellular metabolic process;cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;primary metabolic process Drug metabolism - other enzymes 6 6 6 22.9 22.9 22.9 28.18 1.587E-38 67394000 37808000 29586000 1485 IPI:IPI00019400.1 Thiopurine S-methyltransferase;Thiopurine methyltransferase TPMT P51580 ENST00000309983 K00569 1 0.76318 1.4776 0.74002 1.0118 0.98068 0.9627 3Beta_HSD cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part 3-beta-hydroxy-delta5-steroid dehydrogenase activity;binding;C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity;catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;steroid dehydrogenase activity alcohol metabolic process;biosynthetic process;cellular process;cholesterol biosynthetic process;cholesterol metabolic process;lipid biosynthetic process;lipid metabolic process;metabolic process;steroid biosynthetic process;steroid metabolic process Biosynthesis of steroids 11 11 11 40.5 40.5 40.5 41.9 4.7343E-173 378970000 207720000 171250000 1486 IPI:IPI00019407.1 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating;Protein H105e3 NSDHL;H105E3 Q15738 ENST00000370274 K07748 1 1.0057 2.0178 0.95637 1.3565 1.329 1.2559 Sec3 cell cortex part;cell part;cytoplasmic part;exocyst;intracellular part;macromolecular complex;protein complex cellular process;establishment of localization;establishment of localization in cell;establishment of protein localization;exocytosis;protein transport;secretion;secretion by cell;transport;vesicle-mediated transport 11 11 11 13.9 13.9 13.9 101.98 6.4346E-55 169270000 91933000 77340000 1487 IPI:IPI00019427.4;IPI:IPI00215762.7 Exocyst complex component 1;Exocyst complex component Sec3 EXOC1;SEC3;SEC3L1;BM-012 Q9NV70-1;Q9NV70;Q9NV70-2 ENST00000346134;ENST00000381295;ENST00000401442 2 0.70168 1.4939 0.68087 0.96732 0.92631 0.91647 TROVE cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;ribonucleoprotein complex binding;nucleic acid binding;protein binding;RNA binding biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription;transcription from RNA polymerase III promoter;transcription, DNA-dependent Systemic lupus erythematosus 15 15 15 28.4 28.4 28.4 60.67 4.2914E-136 323970000 178830000 145140000 1488 IPI:IPI00019450.2;IPI:IPI00219287.1 60 kDa SS-A/Ro ribonucleoprotein;Ro 60 kDa autoantigen;TROVE domain family member 2;Sjoegren syndrome type A antigen;Sjoegren syndrome antigen A2 TROVE2;RO60;SSA2 P10155-1;P10155 ENST00000367441;ENST00000367445;ENST00000367446;ENST00000400969 K11089 2 0.63981 0.98763 0.66917 0.82169 0.69658 0.83927 PP2C cell part;cytoplasmic part;cytosol;intracellular part binding;catalytic activity;enzyme activator activity;enzyme regulator activity;protein binding activation of MAPKKK activity;activation of protein kinase activity;positive regulation of kinase activity;regulation of cellular metabolic process;regulation of metabolic process;regulation of phosphate metabolic process;regulation of phosphorylation MAPK signaling pathway;Toll-like receptor signaling pathway 5 5 5 12.1 12.1 12.1 54.643 5.5371E-23 70264000 38018000 32246000 1490 IPI:IPI00019459.1 Mitogen-activated protein kinase kinase kinase 7-interacting protein 1;TGF-beta-activated kinase 1-binding protein 1 MAP3K7IP1;TAB1 Q15750 ENST00000216160 K04403 1 0.96564 1.7565 0.88197 1.3168 1.062 1.1797 dsrm;Pkinase cell part;intracellular catalytic activity;double-stranded RNA binding;nucleic acid binding;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;RNA binding interspecies interaction between organisms;negative regulation of biological process;negative regulation of cell proliferation;negative regulation of cellular process;regulation of cell proliferation;response to biotic stimulus;response to virus 21 21 21 33.4 33.4 33.4 62.094 6.4888E-162 161800000 86561000 75236000 1491 IPI:IPI00019463.3 Interferon-induced, double-stranded RNA-activated protein kinase;Interferon-inducible RNA-dependent protein kinase;Eukaryotic translation initiation factor 2-alpha kinase 2;Protein kinase RNA-activated;p68 kinase;P1/eIF-2A protein kinase EIF2AK2;PKR;PRKR P19525 ENST00000233057;ENST00000379156;ENST00000395127 K08860 1 0.58764 1.1508 0.63441 0.7236 0.7386 0.83862 SDF cell fraction;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;insoluble fraction;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;melanosome;membrane fraction;membrane-bounded vesicle;vesicle amine transmembrane transporter activity;binding;dicarboxylic acid transmembrane transporter activity;organic acid transmembrane transporter activity;organic acid:sodium symporter activity;receptor activity;signal transducer activity;transporter activity amine transport;amino acid transport;carboxylic acid transport;cellular process;dicarboxylic acid transport;establishment of localization;neutral amino acid transport;organic acid transport;transmembrane transport;transport 7 7 7 17.2 17.2 17.2 56.598 3.6736E-76 392870000 213660000 179210000 1492 IPI:IPI00019472.4 Neutral amino acid transporter B(0);Sodium-dependent neutral amino acid transporter type 2;RD114/simian type D retrovirus receptor;Baboon M7 virus receptor;Solute carrier family 1 member 5 SLC1A5;ASCT2;M7V1;RDR;RDRC Q15758 ENST00000306894 K05616 1 0.74073 1.0662 0.67102 0.88958 0.73452 0.85308 S4 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;ribonucleoprotein complex binding;nucleic acid binding;protein binding;RNA binding;rRNA binding cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 5 5 5 38 38 38 21.85 3.7062E-96 121120000 56604000 64520000 1493 IPI:IPI00019488.1 U3 small nucleolar ribonucleoprotein protein IMP3;BRMS2 IMP3;C15orf12;MRPS4 Q9NV31 ENST00000314852;ENST00000403490 1 NaN 4.1046 NaN NaN 2.7369 NaN HLH cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;protein binding;transcription factor activity;transcription regulator activity biosynthetic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription 2 2 2 4.9 4.9 4.9 61.52 6.0359E-17 1272100 790700 481390 1494 IPI:IPI00019490.2 Transcription factor E3 TFE3 P19532 ENST00000315869;ENST00000336239 K09105 1 0.80185 1.6886 0.86268 1.0772 1.1199 1.111 Tctex-1 cell part;cytoskeletal part;dynein complex;intracellular organelle part;intracellular part;macromolecular complex;microtubule;microtubule associated complex;organelle part;protein complex binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;motor activity;protein binding;pyrophosphatase activity 3 3 3 38.9 38.9 38.9 12.452 3.8291E-47 133590000 71579000 62007000 1495 IPI:IPI00019495.1 Dynein light chain Tctex-type 1;T-complex testis-specific protein 1 homolog;Protein CW-1 DYNLT1;TCTEL1;TCTEX-1;TCTEX1 P63172 ENST00000367089 K10420 1 0.58591 1.2842 0.57539 0.78564 0.82179 0.77889 IQ;Myosin_head;Myosin_N;Myosin_tail_1 actin filament bundle;actomyosin;cell division site part;cell projection;cleavage furrow;contractile ring;cytosol;intracellular organelle;macromolecular complex;membrane-bounded organelle;myosin complex;nucleus;organelle;ruffle;stress fiber;uropod actin binding;ATP binding;binding;calmodulin binding;catalytic activity;cytoskeletal protein binding;microfilament motor activity;motor activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity angiogenesis;cell motion;cytokinesis;cytoskeleton organization;immune system process;leukocyte differentiation;membrane protein ectodomain proteolysis;myeloid leukocyte differentiation;organelle organization;proteolysis;system process;transport Tight junction 138 138 117 59.5 59.5 54 226.53 0 23366000000 12917000000 10449000000 1496 IPI:IPI00019502.3;IPI:IPI00395772.5;IPI:IPI00298301.4;IPI:REV_IPI00433279.3 Myosin-9;Myosin heavy chain 9;Myosin heavy chain, non-muscle IIa;Non-muscle myosin heavy chain IIa;Cellular myosin heavy chain, type A;Non-muscle myosin heavy chain A MYH9 P35579-1;P35579;P35579-2 ENST00000216181 K10352 4 0.75696 1.1321 0.82065 0.94984 0.76154 1.1203 MH1;MH2 activin responsive factor complex;cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;receptor complex;transcription factor complex DNA binding;double-stranded DNA binding;nucleic acid binding;receptor signaling protein activity;signal transducer activity;transcription factor activity;transmembrane receptor protein serine/threonine kinase signaling protein activity embryonic axis specification;formation of primary germ layer;mesoderm formation;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regionalization;regulation of transcription, DNA-dependent;transcription Adherens junction;Cell cycle;Colorectal cancer;Pancreatic cancer;Pathways in cancer;TGF-beta signaling pathway;Wnt signaling pathway 9 9 7 19.9 19.9 14.8 52.306 1.0224E-92 198500000 97260000 101240000 1497 IPI:IPI00019548.1;IPI:IPI00220364.2;IPI:IPI00024305.1;IPI:IPI00017730.1 Mothers against decapentaplegic homolog 2;Mad-related protein 2;SMAD 2;hSMAD2;JV18-1;Mothers against decapentaplegic homolog 3;SMAD 3;hSMAD3;JV15-2 SMAD2;MADH2;MADR2;SMAD3;MADH3 Q15796-1;Q15796;Q15796-2;P84022 ENST00000262160;ENST00000356825;ENST00000402690;ENST00000327367 K04500 4 0.79169 1.4636 0.90449 1.0415 1.0584 1.1507 WD40 binding;protein binding 7 7 7 24 24 24 43.603 2.2553E-68 218010000 111370000 106640000 1498 IPI:IPI00019550.1 Protein TSSC1;Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein;Tumor-suppressing STF cDNA 1 protein TSSC1 Q53HC9 ENST00000382125;ENST00000398659 1 0.84621 1.4552 0.84714 1.0448 1.0302 1.064 UQ_con cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;protein complex;UBC13-MMS2 complex;ubiquitin conjugating enzyme complex acid-amino acid ligase activity;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;protein binding;small conjugating protein ligase activity DNA catabolic process;DNA catabolic process, exonucleolytic;DNA double-strand break processing;DNA metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein polyubiquitination;regulation of DNA repair 9 9 5 57.2 57.2 33.1 16.363 1.8908E-107 2007200000 1049300000 957920000 1499 IPI:IPI00019600.3 Ubiquitin-conjugating enzyme E2 variant 2;MMS2;Enterocyte differentiation-associated factor EDAF-1;Enterocyte differentiation-promoting factor;EDPF-1;Vitamin D3-inducible protein;DDVit 1 UBE2V2;MMS2;UEV2 Q15819 ENST00000324746 K10704 1 0.6453 1.2977 0.70643 0.86897 0.86664 0.91703 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity 18 18 18 34.3 34.3 34.3 45.476 0 992460000 527200000 465270000 1500 IPI:IPI00019640.1 Serine/threonine-protein kinase VRK1;Vaccinia-related kinase 1 VRK1 Q99986 ENST00000216639 K08816 1 0.83439 1.5283 0.84684 1.0776 1.0374 1.0923 WD40 cytoplasm;cytoskeleton;intracellular organelle;macromolecular complex;membrane;non-membrane-bounded organelle;nuclear membrane;nuclear outer membrane;nuclear pore;organelle;organelle membrane;organelle outer membrane;outer membrane binding;cytoskeletal protein binding;microtubule binding;nucleic acid binding;protein binding;RNA binding;tubulin binding intracellular transport;mRNA export from nucleus;mRNA transport;nuclear export;nucleic acid transport;nucleobase, nucleoside, nucleotide and nucleic acid transport;nucleocytoplasmic transport;RNA export from nucleus;RNA transport;transport 14 14 14 48.4 48.4 48.4 40.968 0 1078800000 536350000 542500000 1501 IPI:IPI00019733.1 mRNA export factor;mRNA-associated protein mrnp 41;Rae1 protein homolog RAE1;MRNP41 P78406 ENST00000371242;ENST00000395840;ENST00000395841 1 0.87233 1.9464 0.87376 1.1825 1.1645 1.1928 GST_C;GST_N cell part;cytoplasm;intracellular part catalytic activity;glutathione transferase activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor metabolic process Drug metabolism - cytochrome P450;Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450 17 17 17 69.7 69.7 69.7 27.566 1.864E-166 2226900000 876640000 1350300000 1502 IPI:IPI00019755.3 Glutathione S-transferase omega-1;GSTO 1-1 GSTO1;GSTTLP28 P78417 ENST00000369713 K00799 1 0.69966 1.429 0.74292 0.95245 0.97066 1.0224 Metallophos;PPP5;TPR_1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;iron ion binding;phosphatase activity;phosphoprotein phosphatase activity;protein binding;protein serine/threonine phosphatase activity;signal transducer activity nuclear division;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid dephosphorylation;protein modification process;transcription MAPK signaling pathway 18 18 17 44.3 44.3 43.1 56.878 1.2823E-241 770180000 409750000 360440000 1504 IPI:IPI00019812.1 Serine/threonine-protein phosphatase 5;Protein phosphatase T PPP5C;PPP5 P53041 ENST00000012443 K04460 1 0.53084 1.0465 0.49107 0.66436 0.68971 0.68255 fn3;Kelch_1;Kelch_2 cell part;cytoplasm;histone methyltransferase complex;intracellular organelle part;intracellular part;macromolecular complex;methyltransferase complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;DNA binding;nucleic acid binding;protein binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor activity;transcription factor binding;transcription regulator activity biosynthetic process;cell cycle;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent 27 27 27 21.2 21.2 21.2 208.73 0 849970000 481830000 368130000 1505 IPI:IPI00019848.2;IPI:IPI00219326.2;IPI:IPI00847789.1 Host cell factor;HCF-1;C1 factor;VP16 accessory protein;VCAF;CFF;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 HCFC1;HCF1;HFC1 P51610-1;P51610;P51610-2 ENST00000310441;ENST00000354233;ENST00000369984 3 0.76108 1.4131 0.72941 0.92544 0.98804 0.94848 C1-set;MHC_I endosome membrane;integral to membrane;intracellular part;intrinsic to membrane;lysosomal membrane;macromolecular complex;membrane;MHC class I protein complex;MHC protein complex;organelle membrane;organelle part;protein complex;vacuolar membrane binding;protein binding antigen processing and presentation;immune response;immune system process;response to stimulus Hematopoietic cell lineage 5 5 5 17.1 17.1 17.1 36.939 1.7134E-28 234040000 123250000 110790000 1506 IPI:IPI00019849.1;IPI:IPI00513798.3 T-cell surface glycoprotein CD1b CD1B P29016-1;P29016;P29016-2 ENST00000368168 K06448 2 0.56862 NaN 0.72122 0.77205 NaN 0.93016 C1-set;MHC_I endosome membrane;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;macromolecular complex;membrane;MHC class I protein complex;MHC protein complex;organelle membrane;organelle part;protein complex antigen processing and presentation;immune response;immune system process;response to stimulus Hematopoietic cell lineage 2 2 2 5.4 5.4 5.4 37.654 5.2745E-10 10569000 5646200 4922800 1507 IPI:IPI00019850.2 T-cell surface glycoprotein CD1c CD1C P29017 ENST00000368169;ENST00000368170 K06448 1 0.7264 1.6109 0.81117 1.0134 1.0521 1.1003 Aldedh cell fraction;cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle;soluble fraction binding;catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor;protein binding;succinate-semialdehyde dehydrogenase activity acetate metabolic process;alcohol metabolic process;carbohydrate metabolic process;glucose metabolic process;monosaccharide metabolic process;organic acid metabolic process;regulation of neurotransmitter levels Butanoate metabolism;Glutamate metabolism 12 12 12 21.5 21.5 21.5 57.214 8.9453E-92 315410000 171870000 143540000 1508 IPI:IPI00019888.1 Succinate-semialdehyde dehydrogenase, mitochondrial;NAD(+)-dependent succinic semialdehyde dehydrogenase;Aldehyde dehydrogenase family 5 member A1 ALDH5A1;SSADH P51649 ENST00000348925;ENST00000357578 K00139 1 0.32732 0.78308 0.54171 0.44435 0.51332 0.70261 FA_hydroxylase cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part;plasma membrane binding;C-4 methylsterol oxidase activity;catalytic activity;iron ion binding;monooxygenase activity;oxidoreductase activity;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen alcohol metabolic process;fatty acid biosynthetic process;fatty acid metabolic process;lipid biosynthetic process;lipid metabolic process;metabolic process;organic acid metabolic process;steroid biosynthetic process;steroid metabolic process Biosynthesis of steroids 2 2 2 7.2 7.2 7.2 35.215 2.5126E-54 57509000 31625000 25884000 1509 IPI:IPI00019899.1 C-4 methylsterol oxidase;Methylsterol monooxygenase SC4MOL;DESP4;ERG25 Q15800 ENST00000261507 K07750 1 0.94872 1.7579 0.99335 1.2951 1.1219 1.3047 Aldolase_II cytosol;F-actin capping protein complex;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane;membrane-bounded organelle;nucleus;organelle;organelle part;plasma membrane;protein complex actin binding;binding;calmodulin binding;cation binding;cytoskeletal protein binding;identical protein binding;ion binding;metal ion binding;protein binding;protein homodimerization activity;spectrin binding;transcription factor binding actin filament organization;cellular process;cytoskeleton organization;negative regulation of macromolecule metabolic process;negative regulation of metabolic process;organelle organization;regulation of actin polymerization or depolymerization 12 11 11 19.7 18.6 18.6 84.302 1.2568E-155 314490000 152320000 162170000 1510 IPI:IPI00220158.1;IPI:IPI00019901.1;IPI:IPI00253279.2 Alpha-adducin;Erythrocyte adducin subunit alpha ADD1;ADDA P35611-3;P35611;P35611-1;P35611-2 ENST00000264758;ENST00000398129 3 1.0752 1.5754 1.1417 1.2908 1.1352 1.4532 DUF28 4 4 4 21.2 21.2 21.2 32.477 1.3135E-100 127230000 60459000 66776000 1511 IPI:IPI00019903.1 Coiled-coil domain-containing protein 44 CCDC44;PRO0477 Q9BSH4 ENST00000258975 1 1.0005 1.5974 1.008 1.324 1.0847 1.2808 Aldolase_II cell part;cytoplasm;cytoskeletal part;F-actin capping protein complex;intracellular organelle part;intracellular part;macromolecular complex;membrane;organelle part;plasma membrane;protein complex actin binding;binding;calmodulin binding;cation binding;cytoskeletal protein binding;identical protein binding;ion binding;metal ion binding;protein binding;protein heterodimerization activity;protein homodimerization activity;spectrin binding actin filament organization;cellular process;cytoskeleton organization;negative regulation of macromolecule metabolic process;negative regulation of metabolic process;organelle organization;regulation of actin polymerization or depolymerization 13 13 12 18.2 18.2 17.1 80.853 4.5763E-158 550730000 333900000 216840000 1512 IPI:IPI00019904.2;IPI:IPI00220241.3;IPI:IPI00654787.4;IPI:IPI00220240.6;IPI:IPI00181921.3;IPI:IPI00479049.2;IPI:IPI00719156.3 Beta-adducin;Erythrocyte adducin subunit beta ADD2;ADDB P35612-1;P35612;P35612-3;P35612-4;P35612-2 ENST00000264436;ENST00000264439;ENST00000355733;ENST00000356565;ENST00000403045;ENST00000407644 7 0.60962 1.3855 0.67261 0.8201 0.8759 0.88087 ig cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;Golgi membrane;integral to membrane;intrinsic to membrane;melanosome;membrane;membrane-bounded organelle;membrane-bounded vesicle;organelle;organelle membrane;plasma membrane;vesicle binding;carbohydrate binding;mannose binding;monosaccharide binding;protein binding;sugar binding biological regulation;cell communication;cell surface receptor linked signal transduction;cellular process;regulation of biological process;regulation of cellular process;signal transduction 9 9 9 34.8 34.8 34.8 42.2 2.7689E-198 1047000000 552120000 494850000 1513 IPI:IPI00218019.1;IPI:IPI00019906.1 Basigin;Leukocyte activation antigen M6;Collagenase stimulatory factor;Extracellular matrix metalloproteinase inducer;5F7;Tumor cell-derived collagenase stimulatory factor;OK blood group antigen BSG;UNQ6505/PRO21383 P35613-1;P35613;P35613-2 ENST00000333511;ENST00000353555 K06535 2 0.77651 1.518 0.76667 1.0152 1.01 1.0159 adh_short;MaoC_dehydratas;SCP2 cell part;cytoplasmic part;intracellular organelle lumen;intracellular organelle part;intracellular part;membrane-enclosed lumen;microbody lumen;microbody part;organelle lumen;organelle part;peroxisomal matrix;peroxisomal part 3-hydroxyacyl-CoA dehydrogenase activity;binding;catalytic activity;estradiol 17-beta-dehydrogenase activity;lipid binding;lipid transporter activity;protein binding;steroid binding;sterol carrier activity;sterol transporter activity;transporter activity metabolic process;oxidation reduction Bile acid biosynthesis 30 30 30 47.4 47.4 47.4 79.685 0 1885600000 985330000 900290000 1514 IPI:IPI00019912.3;IPI:IPI00020830.1 Peroxisomal multifunctional enzyme type 2;D-bifunctional protein;17-beta-hydroxysteroid dehydrogenase 4;3-hydroxyacyl-CoA dehydrogenase;3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase HSD17B4;EDH17B4 P51659 ENST00000256216 K12405 2 0.79267 1.4792 0.78488 0.98364 0.96529 1.0427 DEAD;Helicase_C cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;membrane;membrane part;nuclear membrane;nuclear part;nuclear pore;organelle membrane;organelle part;pore complex;protein complex ATP binding;ATP-dependent helicase activity;binding;catalytic activity;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity;RNA binding cellular process;establishment of protein localization;intracellular protein transport;intracellular transport;mRNA transport;nucleic acid transport;nucleobase, nucleoside, nucleotide and nucleic acid transport;protein transport;RNA transport;transport Folate biosynthesis 21 21 20 45.8 45.8 43.5 53.974 3.8358E-269 744540000 386390000 358150000 1515 IPI:IPI00019918.5;IPI:IPI00008943.3;IPI:IPI00939593.1;IPI:IPI00759454.1 ATP-dependent RNA helicase DDX19A;DEAD box protein 19A;DDX19-like protein;ATP-dependent RNA helicase DDX19B;DEAD box protein 19B;DEAD box RNA helicase DEAD5 DDX19A;DDX19L;DDX19B;DBP5;DDX19 Q9NUU7;Q9UMR2-1;Q9UMR2;Q9UMR2-2 ENST00000302243;ENST00000288071;ENST00000355992 K01529 4 1.1971 1.7352 1.2897 1.4338 1.2352 1.6975 SCAN;zf-C2H2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;transcription factor activity;transcription regulator activity;transition metal ion binding;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 2 2 2 9.8 9.8 9.8 35.204 2.0053E-54 8423600 3466600 4957000 1516 IPI:IPI00019922.5;IPI:IPI00382777.1 Zinc finger protein 444;Endothelial zinc finger protein 2;Zinc finger and SCAN domain-containing protein 17 ZNF444;EZF2;ZSCAN17 Q8N0Y2-1;Q8N0Y2;Q8N0Y2-2 ENST00000337080;ENST00000391714 K09230 2 NaN 1.295 0.91278 NaN 0.91894 1.1455 TBCC cell part;cytoskeletal part;intracellular organelle part;intracellular part;microtubule;organelle part binding;chaperone binding;protein binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;post-chaperonin tubulin folding pathway;protein folding;protein metabolic process 4 4 4 11 11 11 39.22 3.5643E-05 16047000 7707900 8339400 1517 IPI:IPI00019924.1 Tubulin-specific chaperone C;Tubulin-folding cofactor C TBCC Q15814 ENST00000244625;ENST00000372876 1 0.36198 0.60498 0.32167 0.48073 0.3927 0.42488 PH;Pkinase;RGS cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;nucleus;organelle;plasma membrane ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;purine nucleoside binding;signal transducer activity;transferase activity;transferase activity, transferring phosphorus-containing groups cell communication;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process;signal transduction Chemokine signaling pathway 9 4 4 13.7 6.5 6.5 79.709 3.1411E-53 11273000 6231500 5041400 1518 IPI:IPI00019926.4 Beta-adrenergic receptor kinase 2;G-protein-coupled receptor kinase 3 ADRBK2;BARK2;GRK3 P35626 ENST00000324198 K00910 1 0.80304 1.7721 0.82371 1.0951 1.1413 1.0665 Mov34 cell part;cytoplasmic part;cytosol;intracellular part;macromolecular complex;proteasome regulatory particle;protein complex binding;protein binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Proteasome 10 10 10 36.1 36.1 36.1 37.025 0 1131000000 601720000 529280000 1519 IPI:IPI00019927.2 26S proteasome non-ATPase regulatory subunit 7;26S proteasome regulatory subunit rpn8;26S proteasome regulatory subunit S12;Proteasome subunit p40;Mov34 protein homolog PSMD7;MOV34L P51665 ENST00000219313 K03038 1 0.62408 1.2764 0.73004 0.80362 0.83969 0.9099 6 6 6 27.6 27.6 27.6 23.864 1.9283E-21 189960000 99457000 90503000 1520 IPI:IPI00019962.3 UPF0534 protein C4orf43 C4orf43 Q96EY4 ENST00000358572 1 0.97659 1.5627 0.91851 1.3097 0.98746 1.1633 4 4 4 11.8 11.8 11.8 49.967 6.1507E-133 8126000 3915000 4211000 1521 IPI:IPI00019966.5;IPI:IPI00867737.1 UPF0489 protein C5orf22 C5orf22 Q49AR2-1;Q49AR2 ENST00000325366;ENST00000355907;ENST00000397578 2 0.68217 1.4026 0.82972 0.91067 0.87695 1.0262 TFIIE_alpha cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex;transcription factor TFIIE complex binding;cation binding;ion binding;metal ion binding;protein binding;RNA polymerase II transcription factor activity;transcription regulator activity;transition metal ion binding;zinc ion binding nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;RNA elongation;transcription initiation;transcription initiation from RNA polymerase II promoter Basal transcription factors 6 6 6 15.7 15.7 15.7 49.452 1.1346E-63 70722000 36989000 33733000 1522 IPI:IPI00019977.2 General transcription factor IIE subunit 1;Transcription initiation factor IIE subunit alpha;General transcription factor IIE 56 kDa subunit GTF2E1;TF2E1 P29083 ENST00000283875 K03136 1 0.79288 1.1778 0.63462 1.0538 0.75714 0.85547 TFIIE_beta cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex;transcription factor TFIIE complex binding;DNA binding;nucleic acid binding;protein binding;RNA polymerase II transcription factor activity;transcription regulator activity nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;RNA elongation;transcription initiation;transcription initiation from RNA polymerase II promoter Basal transcription factors 5 5 5 19.6 19.6 19.6 33.043 2.0966E-15 40050000 20421000 19629000 1523 IPI:IPI00019981.1;IPI:IPI00170706.2 Transcription initiation factor IIE subunit beta;General transcription factor IIE subunit 2 GTF2E2;TF2E2 P29084 ENST00000355904 K03137 2 0.57793 1.2008 0.66054 0.80273 0.77302 0.88444 Taxilin cell part;cytoplasm;intracellular part 11 11 11 19.9 19.9 19.9 60.585 1.6639E-65 114820000 61646000 53174000 1524 IPI:IPI00019994.4 Gamma-taxilin;Lipopolysaccharide-specific response protein 5 TXLNG;CXorf15;LSR5 Q9NUQ3 ENST00000380122 1 0.7282 1.1081 0.70322 0.94276 0.76623 0.93047 L27;PDZ basolateral plasma membrane;cell fraction;cell junction;cell-cell junction;cytoskeletal part;insoluble fraction;intracellular part;membrane;membrane fraction;membrane part;organelle part;postsynaptic density;synaptosome;tight junction binding;protein binding cellular process;establishment of localization;establishment of localization in cell;establishment of protein localization;exocytosis;protein complex assembly;protein transport;secretion;secretion by cell;transport;vesicle-mediated transport 6 6 6 42.6 42.6 42.6 21.834 1.5527E-23 216450000 113670000 102790000 1525 IPI:IPI00019997.1;IPI:IPI00005824.1 Lin-7 homolog C;Mammalian lin-seven protein 3;Vertebrate lin-7 homolog 3;Lin-7 homolog A;Mammalian lin-seven protein 1;Vertebrate lin-7 homolog 1;Tax interaction protein 33 LIN7C;MALS3;VELI3;LIN7A;MALS1;VELI1 Q9NUP9;O14910 ENST00000278193;ENST00000261203 2 NaN 1.88 NaN NaN 1.3463 NaN cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 5 4 4 7.6 6.7 6.7 90.071 1.5433E-13 5420500 3307100 2113500 1526 IPI:IPI00019999.2;IPI:IPI00855810.2 Round spermatid basic protein 1 RSBN1 Q5VWQ0-1;Q5VWQ0 ENST00000261441;ENST00000369581 2 0.78161 1.0372 0.92999 1.0352 0.6853 1.1857 cell part;cytoplasm;intracellular part 2 2 2 8.8 8.8 8.8 23.351 0.00016134 7865500 4125600 3739900 1527 IPI:IPI00020002.3 Protein cappuccino homolog CNO Q9NUP1 ENST00000320776 K08366 1 0.75249 1.6361 0.65466 1.0572 1.0272 0.91953 ubiquitin cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding anatomical structure morphogenesis;catabolic process;cellular process;macromolecule catabolic process;metabolic process;protein metabolic process;protein modification process;proteolysis;ubiquitin-dependent protein catabolic process 3 3 3 39.5 39.5 39.5 9.0714 2.5292E-56 320080000 181240000 138840000 1528 IPI:IPI00020008.1 NEDD8;Ubiquitin-like protein Nedd8;Neddylin;Neural precursor cell expressed developmentally down-regulated protein 8 NEDD8 Q15843 ENST00000250495 K12158 1 0.72441 1.2676 0.72944 0.9564 0.83755 0.94241 DEK_C;SAP cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;histone binding;nucleic acid binding;protein binding;RNA polymerase II transcription factor activity;specific RNA polymerase II transcription factor activity;transcription regulator activity cell communication;cellular process;regulation of biosynthetic process;regulation of gene expression;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;signal transduction 14 14 14 29.9 29.9 29.9 42.674 4.8743E-100 934720000 524970000 409750000 1529 IPI:IPI00020021.3 Protein DEK DEK P35659 ENST00000244776;ENST00000397239 1 0.79817 1.4555 0.77602 1.0506 0.96915 0.9946 HLH cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;identical protein binding;nucleic acid binding;protein binding;RNA polymerase II transcription factor activity;transcription factor activity;transcription factor binding;transcription regulator activity positive regulation of transcription from RNA polymerase II promoter by glucose;regulation of transcription from RNA polymerase II promoter by carbon catabolites;regulation of transcription from RNA polymerase II promoter by glucose 4 4 4 14.5 14.5 14.5 36.954 1.6995E-14 133950000 99276000 34676000 1530 IPI:IPI00020037.1;IPI:IPI00216376.1;IPI:IPI00216377.1;IPI:IPI00026559.1 Upstream stimulatory factor 2;Upstream transcription factor 2;FOS-interacting protein;Major late transcription factor 2 USF2 Q15853-1;Q15853;Q15853-2;Q15853-3 ENST00000222305;ENST00000343550 K09106 4 0.77691 1.62 0.84136 1.0549 1.0649 1.088 AAA cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;proteasome complex;protein complex ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Proteasome 24 24 24 69.4 69.4 69.4 47.366 0 1522400000 814880000 707550000 1531 IPI:IPI00020042.2;IPI:IPI00216770.1 26S protease regulatory subunit 6B;Proteasome 26S subunit ATPase 4;MB67-interacting protein;MIP224;TAT-binding protein 7 PSMC4;MIP224;TBP7 P43686-1;P43686;P43686-2 ENST00000157812 K03063 2 0.53071 0.94451 NaN 0.66453 0.66159 NaN DEAD;Helicase_C cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;mitochondrial nucleoid;mitochondrial part;nucleoid;nucleus;organelle;organelle part ATP binding;ATP-dependent helicase activity;binding;catalytic activity;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity;RNA binding 3 3 3 7.6 7.6 7.6 59.55 4.0176E-43 904800 573620 331180 1532 IPI:IPI00020050.5 Probable ATP-dependent RNA helicase DDX28;Mitochondrial DEAD box protein 28 DDX28;MDDX28 Q9NUL7 ENST00000332395 1 NaN 0.83062 NaN NaN 0.5922 NaN zf-CCCH cell part;cytoplasmic part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding developmental process;multicellular organismal development;multicellular organismal process 2 1 1 5.4 3.1 3.1 38.531 0.00025029 441410 219230 222170 1533 IPI:IPI00020062.2;IPI:IPI00219790.1;IPI:IPI00219792.1;IPI:IPI00654643.1 Muscleblind-like protein 3;Muscleblind-like X-linked protein;Cys3His CCG1-required protein;Protein HCHCR MBNL3;CHCR;MBLX39;MBXL Q9NUK0-1;Q9NUK0;Q9NUK0-2;Q9NUK0-3;Q9NUK0-4 ENST00000370839;ENST00000370849;ENST00000370853;ENST00000370857;ENST00000394311 4 0.71823 1.8393 0.78086 1.0372 1.1753 1.0303 Abhydrolase_1 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle catalytic activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides;serine hydrolase activity;serine-type peptidase activity 8 8 8 39.5 39.5 39.5 33.932 9.2546E-212 312510000 157450000 155060000 1534 IPI:IPI00020075.4 Abhydrolase domain-containing protein 10, mitochondrial ABHD10 Q9NUJ1 ENST00000273359 1 0.79531 1.5407 0.71598 1.038 1.0268 0.93905 Rab5-bind;TPR_1 cell part;cytoplasmic part;cytoskeletal part;cytosol;intracellular organelle part;intracellular part;kinesin complex;macromolecular complex;microtubule;microtubule associated complex;organelle part;protein complex binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;microtubule motor activity;motor activity;protein binding;pyrophosphatase activity 12 12 6 21.9 21.9 11.4 72.397 2.0917E-64 264050000 145110000 118940000 1535 IPI:IPI00398708.3;IPI:IPI00479424.2;IPI:IPI00472303.2;IPI:IPI00394906.9;IPI:IPI00337465.6;IPI:IPI00020096.2;IPI:IPI00412642.2;IPI:IPI00921532.1;IPI:IPI00397666.2 Kinesin light chain 1 KLC1;KLC;KNS2 Q07866-9;Q07866;Q07866-4;Q07866-6;Q07866-5;Q07866-7;Q07866-1;Q07866-3;Q07866-2;Q07866-8 ENST00000246489;ENST00000334553;ENST00000347839;ENST00000348520;ENST00000380038;ENST00000389744 9 0.69799 1.4173 0.73448 0.9105 0.96186 0.96819 Histone cell part;chromosomal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;macromolecular complex;membrane-bounded organelle;nucleosome;nucleus;organelle;organelle part;protein-DNA complex binding;DNA binding;nucleic acid binding;protein binding anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;chromatin organization;nucleosome assembly;organelle organization Systemic lupus erythematosus 10 10 3 42.2 42.2 7.2 18.804 6.1361E-191 70354000000 37611000000 32743000000 1536 IPI:IPI00794461.1;IPI:IPI00419833.9;IPI:IPI00020101.9;IPI:IPI00152906.6;IPI:IPI00477495.3;IPI:IPI00303133.8;IPI:IPI00554798.2;IPI:IPI00329665.8;IPI:IPI00018534.4 Histone H2B type 1-N;H2B.d;H2B/d;Histone H2B type 1-K;HIRA-interacting protein 1;Histone H2B type 1-C/E/F/G/I;H2B.a/g/h/k/l;H2B.1 A;H2B/g;H2B/h;H2B/k;H2B/l;Histone H2B type 1-D;H2B.b;H2B/b;H2B.1 B;HIRA-interacting protein 2;Histone H2B type F-S;Histone H2B type 1-H;H2B.j;H2B/j;Histone H2B type 1-M;Histone H2B type 2-F;Histone H2B type 1-L;H2B.c;H2B/c HIST1H2BN;H2BFD;HIST1H2BK;H2BFT;HIRIP1;HIST1H2BC;H2BFL;HIST1H2BE;H2BFH;HIST1H2BF;H2BFG;HIST1H2BG;H2BFA;HIST1H2BI;H2BFK;HIST1H2BD;H2BFB;HIRIP2;H2BFS;HIST1H2BH;H2BFJ;HIST1H2BM;H2BFE;HIST2H2BF;HIST1H2BL;H2BFC Q99877;O60814;P62807;P58876;P57053;Q93079;Q99879;Q5QNW6;Q99880 ENST00000369385;ENST00000406034;ENST00000356950;ENST00000396891;ENST00000314332;ENST00000339812;ENST00000356530;ENST00000359985;ENST00000377733;ENST00000396984;ENST00000289316;ENST00000377777;ENST00000356350;ENST00000359465;ENST00000369167;ENST00000377401 K11252 9 0.98687 2.0107 0.98237 1.2861 1.433 1.2681 PI3_PI4_kinase cell part;cytoplasm;integral to membrane;integral to plasma membrane;intracellular part;intrinsic to membrane;intrinsic to plasma membrane;membrane part;membrane raft;plasma membrane part 1-phosphatidylinositol 4-kinase activity;ATP binding;binding;catalytic activity;inositol or phosphatidylinositol kinase activity;kinase activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding biosynthetic process;cellular process;glycerophospholipid metabolic process;lipid biosynthetic process;lipid metabolic process;metabolic process;phosphatidylinositol biosynthetic process;phospholipid biosynthetic process;phospholipid metabolic process 10 10 10 23.8 23.8 23.8 54.022 6.5785E-84 89595000 46401000 43195000 1537 IPI:IPI00020124.1 Phosphatidylinositol 4-kinase type 2-alpha;Phosphatidylinositol 4-kinase type II-alpha PI4K2A Q9BTU6 ENST00000370631 1 0.72657 1.4892 0.73954 0.98442 0.95049 1.005 Rep_fac-A_C;Rep-A_N;tRNA_anti cytoplasm;cytoskeleton;DNA replication factor A complex;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nuclear body;organelle;organelle part;PML body;protein complex binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;single-stranded DNA binding;structure-specific DNA binding;transition metal ion binding;zinc ion binding DNA catabolic process;DNA metabolic process;DNA replication;DNA-dependent DNA replication;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleotide-excision repair, DNA damage removal;nucleotide-excision repair, DNA gap filling DNA replication;Homologous recombination;Mismatch repair;Nucleotide excision repair 34 34 34 57.1 57.1 57.1 68.137 0 1638600000 894550000 744020000 1538 IPI:IPI00020127.1;IPI:IPI00022353.4 Replication protein A 70 kDa DNA-binding subunit;Replication factor A protein 1;Single-stranded DNA-binding protein RPA1;REPA1;RPA70 P27694 ENST00000254719 K07466 2 0.5061 0.91268 0.50063 0.68225 0.58439 0.66569 U3_assoc_6 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 7 7 7 13.7 13.7 13.7 70.193 4.7865E-107 185420000 95490000 89931000 1539 IPI:IPI00020128.2 U3 small nucleolar RNA-associated protein 6 homolog;Hepatocellular carcinoma-associated antigen 66;Multiple hat domains protein UTP6;C17orf40;HCA66;MHAT Q9NYH9 ENST00000261708 1 0.82218 1.3171 0.89583 1.1077 0.95931 1.2314 SH3_1;UIM;VHS cell part;cytoplasmic part;cytosol;early endosome membrane;endosomal part;endosome membrane;intracellular organelle part;intracellular part;membrane;organelle membrane;organelle part binding;molecular adaptor activity;molecular transducer activity;protein binding;protein binding, bridging;SH3/SH2 adaptor activity;signal transducer activity cell communication;cellular process;establishment of protein localization;intracellular protein transport;intracellular transport;protein transport;regulation of biological process;regulation of cellular process;signal transduction;transport Jak-STAT signaling pathway 5 5 3 9.4 9.4 5.9 59.179 8.3201E-47 140930000 68750000 72181000 1540 IPI:IPI00020178.1;IPI:IPI00607769.4 Signal transducing adapter molecule 1 STAM;STAM1 Q92783-1;Q92783;Q92783-2 ENST00000377524 K04705 2 0.85387 1.6593 0.89214 1.1234 1.0521 1.1946 Y_phosphatase cell part;cytoplasmic part;early endosome;endoplasmic reticulum;endosome;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;organelle;plasma membrane;spindle binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;phosphatase activity;phosphoprotein phosphatase activity;prenylated protein tyrosine phosphatase activity;protein binding;protein tyrosine phosphatase activity cellular biopolymer metabolic process;cellular process;dephosphorylation;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid dephosphorylation;protein metabolic process;protein modification process 4 4 4 34.1 34.1 34.1 19.127 2.611E-46 96217000 51005000 45212000 1542 IPI:IPI00020191.1;IPI:IPI00020164.1;IPI:IPI00040537.1 Protein tyrosine phosphatase type IVA 2;Protein-tyrosine phosphatase 4a2;Protein-tyrosine phosphatase of regenerating liver 2;PTP(CAAXII);HU-PP-1;OV-1;Protein tyrosine phosphatase type IVA 1;Protein-tyrosine phosphatase 4a1;Protein-tyrosine phosphatase of regenerating liver 1;PTP(CAAXI) PTP4A2;PRL2;PTPCAAX2;BM-008;PTP4A1;PRL1;PTPCAAX1 Q12974-1;Q12974;Q93096;Q12974-2 ENST00000344035;ENST00000356536;ENST00000370651 K01104 3 0.73976 1.3961 0.7277 1.0151 0.87262 1.0158 RRM_1;zf-RanBP cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;RNA binding;transition metal ion binding;zinc ion binding 7 5 5 15.9 15.9 15.9 61.829 7.264E-235 422870000 224350000 198520000 1543 IPI:IPI00294426.3;IPI:IPI00020194.1 TATA-binding protein-associated factor 2N;RNA-binding protein 56;TAFII68;TAF(II)68 TAF15;RBP56;TAF2N Q92804-1;Q92804;Q92804-2 ENST00000311979;ENST00000394533 2 0.29844 0.64042 0.31116 0.40362 0.44778 0.40027 Arm binding;protein binding 7 7 7 17.8 17.8 17.8 54.141 3.3978E-212 155120000 94088000 61028000 1544 IPI:IPI00020196.5 Armadillo repeat-containing protein 6 ARMC6 Q6NXE6 ENST00000392336 1 0.43829 0.93113 0.45895 0.56028 0.61423 0.59868 CNH;Pkinase catalytic activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;receptor signaling protein serine/threonine kinase activity;signal transducer activity activation of MAPK activity;activation of MAPKKK activity;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;regulation of protein amino acid phosphorylation 5 5 5 6 6 6 91.295 3.1487E-06 36036000 20091000 15945000 1545 IPI:IPI00020258.3 Mitogen-activated protein kinase kinase kinase kinase 1;MAPK/ERK kinase kinase kinase 1;Hematopoietic progenitor kinase MAP4K1;HPK1 Q92918 ENST00000221409 1 0.71962 1.6256 0.74135 0.9689 1.0907 0.99847 GCN5L1 BLOC complex;BLOC-1 complex;cell part;cytoplasmic part;cytosolic part;intracellular part;macromolecular complex;protein complex binding;protein binding cellular component organization;cellular process;melanosome organization;organelle organization;pigment granule organization;platelet dense granule organization;secretory granule organization;vesicle organization 3 3 3 19 19 19 17.262 1.7447E-19 27269000 14892000 12377000 1546 IPI:IPI00020319.2 Biogenesis of lysosome-related organelles complex 1 subunit 1;GCN5-like protein 1;Protein RT14 BLOC1S1;BLOS1;GCN5L1;RT14 P78537 ENST00000257899 1 1.0863 1.6751 NaN 1.3687 1.1285 NaN Arginase cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle arginase activity;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines;manganese ion binding arginine metabolic process;cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;metabolic process;nitric oxide biosynthetic process;nitrogen compound metabolic process;organic acid metabolic process;urea cycle Arginine and proline metabolism 2 2 2 6.5 6.5 6.5 38.577 1.3853E-26 5644500 2792600 2851900 1547 IPI:IPI00020332.1 Arginase-2, mitochondrial;Non-hepatic arginase;Kidney-type arginase ARG2 P78540 ENST00000261783 K01476 1 NaN 1.0187 NaN NaN 0.66524 NaN A_deamin;dsrm cell part;intracellular adenosine deaminase activity;binding;catalytic activity;double-stranded RNA binding;hydrolase activity;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;nucleic acid binding;RNA binding;zinc ion binding cellular biopolymer metabolic process;cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing 3 3 3 5.8 5.8 5.8 80.762 1.216E-35 4272100 2246000 2026100 1549 IPI:IPI00020368.1;IPI:IPI00184874.7;IPI:IPI00334613.1;IPI:IPI00477012.1 Double-stranded RNA-specific editase 1;dsRNA adenosine deaminase;RNA-editing deaminase 1;RNA-editing enzyme 1 ADARB1;ADAR2;DRADA2;RED1 P78563-1;P78563;P78563-4;P78563-3;P78563-2 ENST00000348831;ENST00000360697;ENST00000389860;ENST00000389861;ENST00000389862 K01506 4 0.75121 1.5653 0.72323 1.0025 1.05 0.95132 Peptidase_S8 cell part;cytoplasm;intracellular part aminopeptidase activity;catalytic activity;endopeptidase activity;exopeptidase activity;hydrolase activity;peptidase activity;serine hydrolase activity;serine-type endopeptidase activity;serine-type peptidase activity;tripeptidyl-peptidase activity biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis 45 45 45 42.8 42.8 42.8 138.35 0 1843400000 1008700000 834680000 1550 IPI:IPI00020416.8 Tripeptidyl-peptidase 2;Tripeptidyl-peptidase II;Tripeptidyl aminopeptidase TPP2 P29144 ENST00000376052;ENST00000376065 K01280 1 0.5546 1.0938 0.46563 0.72834 0.72931 0.64761 YL1;YL1_C cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;protein complex binding;DNA binding;nucleic acid binding;RNA polymerase II transcription factor activity;transcription factor activity;transcription regulator activity chromatin organization;negative regulation of transcription from RNA polymerase II promoter;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 2 2 2 6.6 6.6 6.6 40.594 0.0039106 33686000 19966000 13721000 1551 IPI:IPI00020434.1 Vacuolar protein sorting-associated protein 72 homolog;Transcription factor-like 1;Protein YL-1 VPS72;TCFL1;YL1 Q15906 ENST00000354473;ENST00000368892 K11664 1 0.91917 1.6598 0.88604 1.2199 1.0841 1.1785 Ras cell part;cytoplasmic part;endosomal part;endosome membrane;Golgi apparatus part;intracellular organelle part;intracellular part;membrane;organelle membrane;organelle part;plasma membrane;recycling endosome membrane;trans-Golgi network binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleotide binding;pyrophosphatase activity cell communication;cellular process;establishment of protein localization;intracellular signaling cascade;protein transport;regulation of biological process;signal transduction;small GTPase mediated signal transduction;transport 12 12 12 56 56 56 24.488 6.6326E-170 1518000000 779810000 738190000 1552 IPI:IPI00020436.4;IPI:IPI00941638.1;IPI:IPI00027993.2 Ras-related protein Rab-11B;GTP-binding protein YPT3;Ras-related protein Rab-11A;YL8 RAB11B;YPT3;RAB11A;RAB11 Q15907;P62491 ENST00000328024;ENST00000261890 K07905;K07904 3 0.82549 1.8033 0.81372 1.1198 1.177 1.1087 dNK cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;deoxycytidine kinase activity;kinase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;nucleotide metabolic process;pyrimidine nucleotide metabolic process Purine metabolism;Pyrimidine metabolism 10 10 10 32.3 32.3 32.3 30.518 2.5106E-61 166400000 87379000 79016000 1554 IPI:IPI00020454.1 Deoxycytidine kinase DCK P27707 ENST00000286648 K00893 1 0.83598 0.87645 NaN 1.1493 0.55676 NaN Selenoprotein_S integral to endoplasmic reticulum membrane;integral to membrane;integral to organelle membrane;intrinsic to endoplasmic reticulum membrane;intrinsic to membrane;intrinsic to organelle membrane;macromolecular complex;protein-lipid complex antioxidant activity;binding;enzyme binding;molecular transducer activity;protein binding;receptor activity;selenium binding;signal transducer activity anti-apoptosis;intracellular protein transport;misfolded or incompletely synthesized protein catabolic process;negative regulation of cytokine production;proteolysis;regulation of cytokine production;transport;ubiquitin-dependent protein catabolic process 2 2 2 6.9 6.9 6.9 21.116 0.00017642 6433100 2634300 3798800 1556 IPI:IPI00020468.4 Selenoprotein S;VCP-interacting membrane protein SELS;VIMP;AD-015;SBBI8 Q9BQE4 ENST00000398226 1 NaN 1.716 0.8346 NaN 1.1874 1.233 DUF850 cell part;integral to membrane;intrinsic to membrane;membrane part 6 6 6 28.7 28.7 28.7 29.952 2.5953E-123 17204000 8985200 8218600 1558 IPI:IPI00020472.1;IPI:IPI00607849.2 Transmembrane protein 111 TMEM111 Q9P0I2-1;Q9P0I2;Q9P0I2-2 ENST00000245046 2 0.024065 NaN NaN 0.032758 NaN NaN cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;extracellular region;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;membrane-bounded vesicle;organelle;secretory granule;vesicle binding;collagen binding;extracellular matrix binding;fibronectin binding;glycoprotein binding;growth factor activity;laminin binding;laminin-1 binding;protein binding;protein N-terminus binding;receptor binding body fluid secretion;cell communication;intracellular signaling cascade;positive regulation of protein amino acid phosphorylation;protein localization;regulation of protein amino acid phosphorylation;signal transduction;system process;transport 2 2 2 13.8 13.8 13.8 14.246 0.00011383 4215400 4204900 10503 1559 IPI:IPI00020487.1 Extracellular glycoprotein lacritin LACRT Q9GZZ8 ENST00000257867 1 0.58586 1.0736 0.63645 0.70148 0.76203 0.77361 TRM;zf-CCCH binding;catalytic activity;methyltransferase activity;N-methyltransferase activity;nucleic acid binding;RNA binding;RNA methyltransferase activity;tRNA (guanine-N2-)-methyltransferase activity;tRNA methyltransferase activity;zinc ion binding cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;tRNA metabolic process;tRNA processing 10 10 10 20.6 20.6 20.6 72.233 9.5592E-115 114960000 62991000 51970000 1562 IPI:IPI00020508.1;IPI:IPI00178861.1 N(2),N(2)-dimethylguanosine tRNA methyltransferase;tRNA(guanine-26,N(2)-N(2)) methyltransferase;tRNA 2,2-dimethylguanosine-26 methyltransferase;tRNA(m(2,2)G26)dimethyltransferase TRMT1 Q9NXH9-1;Q9NXH9;Q9NXH9-2 ENST00000221504;ENST00000357720 K00555 2 0.6893 1.4321 0.65011 0.91279 0.9415 0.8775 MitoNEET_N;zf-CDGSH cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial membrane;mitochondrial outer membrane;mitochondrial part;organelle membrane;organelle outer membrane;organelle part;outer membrane 2 iron, 2 sulfur cluster binding;binding;cation binding;ion binding;iron ion binding;iron-sulfur cluster binding;metal cluster binding;metal ion binding;transition metal ion binding 7 7 7 52.8 52.8 52.8 12.199 8.4481E-155 463330000 255110000 208220000 1563 IPI:IPI00020510.1 CDGSH iron sulfur domain-containing protein 1;MitoNEET CISD1;C10orf70;ZCD1;MDS029 Q9NZ45 ENST00000333926 1 0.77994 1.4581 0.70905 0.96304 0.9877 0.92184 Use1 cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part binding;protein binding catabolic process;cellular process;lysosomal transport;macromolecule catabolic process;metabolic process;protein catabolic process;protein metabolic process;protein transport;transport;vacuolar transport;vesicle-mediated transport SNARE interactions in vesicular transport 6 6 6 24.3 24.3 24.3 29.345 1.7522E-59 36039000 18251000 17787000 1564 IPI:IPI00020515.3;IPI:IPI00549501.1;IPI:IPI00549814.1 Vesicle transport protein USE1;USE1-like protein;Putative MAPK-activating protein PM26;Protein p31 USE1;USE1L;MDS032 Q9NZ43-1;Q9NZ43;Q9NZ43-2;Q9NZ43-3 ENST00000263897;ENST00000379776 K08507 3 1.2638 NaN NaN 1.6913 NaN NaN 2 2 2 5.6 5.6 5.6 40.514 5.0198E-11 4615200 3230500 1384700 1565 IPI:IPI00020529.2;IPI:IPI00410631.4;IPI:IPI00953673.1 Protein FAM45B;Protein FAM45A FAM45B;HT011;FAM45A Q6NSW5;Q8TCE6-1;Q8TCE6;Q8TCE6-2 ENST00000408950;ENST00000361432 3 0.76229 1.6997 0.82026 1.0051 1.1486 1.0601 4HBT acyl-CoA thioesterase activity;catalytic activity;CoA hydrolase activity;hydrolase activity;hydrolase activity, acting on ester bonds;thiolester hydrolase activity anatomical structure formation;cellular component assembly;cellular component organization;macromolecular complex subunit organization;protein complex assembly;protein homooligomerization;protein oligomerization;protein tetramerization 3 3 3 25 25 25 14.96 2.5648E-79 337650000 187980000 149670000 1566 IPI:IPI00020530.1 Acyl-coenzyme A thioesterase 13;Thioesterase superfamily member 2 ACOT13;THEM2;HT012;PNAS-27 Q9NPJ3 ENST00000230048 1 0.78027 1.6335 0.74859 0.97746 1.057 0.95625 RhoGAP cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle binding;molecular adaptor activity;molecular transducer activity;protein binding;protein binding, bridging;protein domain specific binding;SH3 domain binding;SH3/SH2 adaptor activity;signal transducer activity cell communication;cellular process;intracellular signaling cascade;Ras protein signal transduction;regulation of biological process;Rho protein signal transduction;signal transduction;small GTPase mediated signal transduction 15 15 15 38.3 38.3 38.3 50.435 7.2871E-111 384480000 207390000 177100000 1568 IPI:IPI00020567.3 Rho GTPase-activating protein 1;Rho-type GTPase-activating protein 1;Rho-related small GTPase protein activator;GTPase-activating protein rhoOGAP;p50-RhoGAP;CDC42 GTPase-activating protein ARHGAP1;CDC42GAP;RHOGAP1 Q07960 ENST00000311956 1 0.75519 1.9152 0.80305 1.0679 1.1346 1.1102 Calreticulin cytosol;endoplasmic reticulum lumen;extracellular matrix;extracellular space;macromolecular complex;membrane-enclosed lumen;MHC class I peptide loading complex;nucleus;organelle;polysome;proteinaceous extracellular matrix;ribonucleoprotein complex binding;calcium ion binding;complement binding;complement component C1q binding;DNA binding;integrin binding;mRNA binding;nucleic acid binding;opsonin binding;protein binding;receptor binding;RNA binding;sugar binding;zinc ion binding negative regulation of transcription from RNA polymerase II promoter;peptide antigen assembly with MHC class I protein complex;peptide antigen assembly with MHC protein complex;regulation of DNA replication;regulation of transcription, DNA-dependent Antigen processing and presentation 20 20 20 72.4 72.4 72.4 48.141 0 9874600000 5004700000 4869900000 1569 IPI:IPI00020599.1 Calreticulin;CRP55;Calregulin;HACBP;ERp60;grp60 CALR;CRTC P27797 ENST00000316448 K08057 1 0.86417 1.7379 0.80136 1.1463 1.0926 1.0997 Pkinase ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cell communication;cell surface receptor linked signal transduction;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;signal transduction Adherens junction;Circadian rhythm - plant;Tight junction;Wnt signaling pathway 17 16 16 54.6 52.9 52.9 41.213 3.6152E-265 983510000 508300000 475210000 1570 IPI:IPI00020602.1 Casein kinase II subunit alpha' CSNK2A2;CK2A2 P19784 ENST00000262506 K03097 1 1.0946 1.8047 1.0641 1.3041 1.1507 1.3967 Arginosuc_synth cell part;cytoplasm;intracellular part argininosuccinate synthase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding arginine biosynthetic process;arginine metabolic process;cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;metabolic process;nitrogen compound metabolic process;organic acid metabolic process;urea cycle Alanine and aspartate metabolism;Arginine and proline metabolism 21 21 21 45.1 45.1 45.1 50.817 5.8197E-303 1389900000 697670000 692260000 1571 IPI:IPI00020632.4 Argininosuccinate synthase;Citrulline--aspartate ligase ASS1;ASS P00966 ENST00000334909;ENST00000352480;ENST00000372393;ENST00000372394 K01940 1 0.76894 1.567 0.76272 1.0421 0.99077 1.0261 Peptidase_M49 cell part;cytoplasm;intracellular part aminopeptidase activity;binding;catalytic activity;cation binding;dipeptidyl-peptidase activity;exopeptidase activity;hydrolase activity;ion binding;metal ion binding;metallopeptidase activity;peptidase activity;zinc ion binding biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis 13 13 13 23.7 23.7 23.7 82.588 0 1537200000 811670000 725520000 1572 IPI:IPI00020672.4;IPI:IPI00645171.1 Dipeptidyl-peptidase 3;Dipeptidyl-peptidase III;Dipeptidyl aminopeptidase III;Dipeptidyl arylamidase III DPP3 Q9NY33-1;Q9NY33 ENST00000347422;ENST00000360510 K01277 2 0.83276 1.5947 0.78002 1.1455 1.0058 1.0436 Exonuc_X-T cell part;intracellular binding;catalytic activity;exonuclease activity;hydrolase activity;hydrolase activity, acting on ester bonds;nuclease activity;nucleic acid binding 4 4 4 11.9 11.9 11.9 37.238 1.9722E-21 71645000 38572000 33073000 1573 IPI:IPI00020701.5;IPI:IPI00888358.1;IPI:IPI00644349.3 Prion protein-interacting protein;Prion interactor 1 PRNPIP;PINT1;PRNPIP1 O43414-1;O43414;O43414-2;O43414-3 ENST00000372253;ENST00000372257;ENST00000372259 3 0.83275 1.6743 NaN 1.0812 1.1547 NaN cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial membrane;mitochondrial outer membrane;mitochondrial part;organelle membrane;organelle outer membrane;organelle part;outer membrane binding;molecular transducer activity;protein binding;signal transducer activity defense response;immune response;immune system process;positive regulation of signal transduction;regulation of protein kinase cascade;regulation of signal transduction;response to biotic stimulus;response to stress;response to virus 3 3 3 7.4 7.4 7.4 56.527 3.6922E-53 17822000 9553900 8268600 1574 IPI:IPI00020719.2;IPI:IPI00411576.1 Mitochondrial antiviral-signaling protein;Interferon-beta promoter stimulator protein 1;Virus-induced-signaling adapter;CARD adapter inducing interferon-beta;Putative NF-kappa-B-activating protein 031N MAVS;IPS1;KIAA1271;VISA Q7Z434-1;Q7Z434 ENST00000356687;ENST00000358134 2 1.0138 1.9863 1.08 1.2909 1.3378 1.4006 Synaptobrevin cytoplasmic vesicle membrane;endocytic vesicle membrane;endoplasmic reticulum membrane;endosome membrane;Golgi apparatus;integral to membrane;lysosomal membrane;membrane;secretory granule membrane;vacuolar membrane;vesicle membrane binding;protein binding cell activation;ER to Golgi vesicle-mediated transport;exocytosis;immune effector process;immune system process;membrane fusion;myeloid leukocyte activation;organelle organization;phagocytosis, engulfment;transport;vacuolar transport;vesicle fusion SNARE interactions in vesicular transport 6 6 6 28.2 28.2 28.2 24.935 4.7055E-33 119280000 59402000 59883000 1575 IPI:IPI00020887.3;IPI:IPI00401804.3;IPI:IPI00013236.3 Vesicle-associated membrane protein 7;Synaptobrevin-like protein 1;Tetanus-insensitive VAMP VAMP7;SYBL1 P51809-1;P51809;P51809-3;P51809-2 ENST00000262640;ENST00000286448;ENST00000369427 K08515 3 0.75479 1.3258 0.62176 0.99528 0.85023 0.8326 Pkinase;Pkinase_C cell part;cytoplasm;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part ATP binding;binding;catalytic activity;kinase activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cell communication;intracellular signaling cascade;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein kinase cascade;protein modification process;signal transduction;skeletal system development Long-term potentiation;MAPK signaling pathway;mTOR signaling pathway;Progesterone-mediated oocyte maturation 19 19 11 27 27 15.8 83.735 7.6478E-121 280450000 151820000 128630000 1576 IPI:IPI00020898.1;IPI:IPI00478653.2;IPI:IPI00300321.5 Ribosomal protein S6 kinase alpha-3;90 kDa ribosomal protein S6 kinase 3;p90-RSK 3;Ribosomal S6 kinase 2;pp90RSK2;Insulin-stimulated protein kinase 1;MAP kinase-activated protein kinase 1b RPS6KA3;ISPK1;RSK2 P51812 ENST00000379565 K04373 3 0.82676 1.6581 0.82559 1.1095 1.1246 1.0904 Inositol_P cell part;cytoplasm;intracellular part binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;inositol or phosphatidylinositol phosphatase activity;inositol-1(or 4)-monophosphatase activity;lithium ion binding;magnesium ion binding;phosphatase activity cell communication;glycerophospholipid metabolic process;lipid metabolic process;metabolic process;phosphate metabolic process;phosphatidylinositol biosynthetic process;phospholipid metabolic process;phosphorus metabolic process;signal transduction Inositol phosphate metabolism;Phosphatidylinositol signaling system;Streptomycin biosynthesis 9 9 9 41.5 41.5 41.5 30.188 4.3827E-118 381240000 199930000 181310000 1577 IPI:IPI00020906.1 Inositol monophosphatase;Inositol-1(or 4)-monophosphatase;Lithium-sensitive myo-inositol monophosphatase A1 IMPA1;IMPA P29218 ENST00000256108 K01092 1 0.74064 1.8105 NaN 0.93912 1.2243 NaN cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle;perinuclear region of cytoplasm binding;protein binding 3 3 3 34.6 34.6 34.6 14.649 8.955E-08 9371300 5378500 3992800 1578 IPI:IPI00020915.1;IPI:IPI00095951.3 MORF4 family-associated protein 1;Protein PGR1;Protein associated with MRG of 14 kDa MRFAP1;PAM14;PGR1 Q9Y605 ENST00000320912;ENST00000382581 2 0.65632 1.5189 0.71969 0.91484 0.97375 0.96603 HMG_box cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;mitochondrial nucleoid;mitochondrial part;nucleoid;nucleus;organelle;organelle part binding;DNA binding;nucleic acid binding;transcription factor activity;transcription regulator activity DNA metabolic process;DNA replication;DNA-dependent DNA replication;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription;transcription, DNA-dependent Huntington's disease 9 9 9 36.6 36.6 36.6 29.096 2.3068E-59 697380000 367730000 329650000 1579 IPI:IPI00020928.1 Transcription factor A, mitochondrial;mtTFA;Mitochondrial transcription factor 1;Transcription factor 6-like 2 TFAM;TCF6L2 Q00059 ENST00000373899 K11830 1 0.37289 0.55778 0.37831 0.46639 0.39145 0.48481 SQS_PSY cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part binding;catalytic activity;farnesyl-diphosphate farnesyltransferase activity;farnesyltranstransferase activity;magnesium ion binding;oxidoreductase activity;prenyltransferase activity;protein binding;transferase activity alcohol metabolic process;cholesterol biosynthetic process;cholesterol metabolic process;isoprenoid biosynthetic process;isoprenoid metabolic process;lipid metabolic process;metabolic process;steroid biosynthetic process;steroid metabolic process Biosynthesis of steroids;Terpenoid biosynthesis 16 16 16 43.4 43.4 43.4 48.115 0 1186500000 662820000 523660000 1580 IPI:IPI00020944.1 Squalene synthetase;Farnesyl-diphosphate farnesyltransferase;FPP:FPP farnesyltransferase FDFT1 P37268 ENST00000220584 K00801 1 0.85526 1.4479 0.83288 1.1609 0.98265 1.1259 PP2C;PP2C_C cell part;macromolecular complex;protein complex;protein serine/threonine phosphatase complex binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;magnesium ion binding;phosphatase activity;phosphoprotein phosphatase activity;protein serine/threonine phosphatase activity;signal transducer activity cell communication;cell surface receptor linked signal transduction;positive regulation of biosynthetic process;positive regulation of metabolic process;regulation of biosynthetic process;regulation of transcription, DNA-dependent;signal transduction MAPK signaling pathway 12 12 10 37.4 37.4 31.7 42.447 8.5801E-165 268630000 117860000 150780000 1581 IPI:IPI00020950.3;IPI:IPI00216196.1 Protein phosphatase 1A;Protein phosphatase 2C isoform alpha PPM1A;PPPM1A P35813-1;P35813;P35813-2 ENST00000325642;ENST00000325658;ENST00000395075;ENST00000395076 K04457 2 0.73766 1.7291 0.83268 1.0012 1.0498 1.1188 PWWP cell part;cytoplasm;extracellular region part;extracellular space;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;carbohydrate binding;DNA binding;glycosaminoglycan binding;growth factor activity;heparin binding;nucleic acid binding;nucleotide binding;pattern binding;polysaccharide binding;protein binding;receptor binding cell communication;cell proliferation;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;signal transduction;transcription 14 13 13 50.4 47.1 47.1 26.788 9.2279E-76 1387700000 742820000 644890000 1582 IPI:IPI00020956.1 Hepatoma-derived growth factor;High-mobility group protein 1-like 2 HDGF;HMG1L2 P51858 ENST00000357325;ENST00000368206 1 1.3411 2.2488 1.2935 1.7945 1.4249 1.7426 UQ_con cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle acid-amino acid ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleoside binding;nucleotide binding;purine nucleoside binding;ubiquitin-protein ligase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;protein metabolic process;protein modification process;protein ubiquitination;proteolysis;regulation of metabolic process;ubiquitin-dependent protein catabolic process Ubiquitin mediated proteolysis 2 2 2 16.4 16.4 16.4 20.655 8.3516E-13 22675000 11029000 11646000 1583 IPI:IPI00020965.1 Ubiquitin-conjugating enzyme E2 H;Ubiquitin-protein ligase H;Ubiquitin carrier protein H;UbcH2;E2-20K UBE2H P62256 ENST00000355621 K10576 1 0.87458 1.4634 0.80328 1.0887 1.0599 1.0656 Bromodomain;Creb_binding;DUF902;DUF906;KIX;zf-TAZ;ZZ cell part;cytoplasm;histone acetyltransferase complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex catalytic activity;DNA binding;histone acetyltransferase activity;lysine N-acetyltransferase activity;nucleic acid binding;p53 binding;transcription coactivator activity;transcription cofactor activity;transcription factor activity chromatin organization;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein amino acid acetylation;protein complex assembly;protein modification process;regulation of transcription, DNA-dependent;response to hypoxia;transcription 4 4 4 1.7 1.7 1.7 265.35 1.7203E-11 18607000 9476100 9130800 1584 IPI:IPI00023339.2;IPI:IPI00020985.4 CREB-binding protein;Histone acetyltransferase p300;E1A-associated protein p300 CREBBP;CBP;EP300;P300 Q92793;Q09472 ENST00000262367;ENST00000382070;ENST00000263253 2 0.81841 1.5845 0.80172 1.1038 1.0489 1.1564 cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;double-stranded RNA binding;nucleic acid binding;RNA binding 11 11 11 24.8 24.8 24.8 61.124 3.3489E-241 35300000 19415000 15885000 1585 IPI:IPI00020991.2 CDKN2A-interacting protein;Collaborator of ARF CDKN2AIP;CARF Q9NXV6 ENST00000302350 1 0.84583 1.6628 0.89796 1.1361 1.112 1.1791 EF_TS;UBA cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;nucleus;organelle binding;nucleic acid binding;transcription elongation regulator activity;transcription regulator activity;translation elongation factor activity;translation factor activity, nucleic acid binding;translation regulator activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation 8 8 8 28 28 28 37.656 2.1131E-113 258110000 137600000 120510000 1586 IPI:IPI00216260.1;IPI:IPI00021016.3 Elongation factor Ts, mitochondrial TSFM P43897-2;P43897;P43897-1 ENST00000323833;ENST00000350762 K02357 2 0.6844 1.0305 0.63541 0.88258 0.6709 0.821 Band_3_cyto;HCO3_cotransp apical plasma membrane;basolateral plasma membrane;cell part;cell projection;integral to membrane;intracellular part;intrinsic to membrane;membrane part;microvillus;organelle part;plasma membrane part;stereocilium anion transmembrane transporter activity;binding;cation transmembrane transporter activity;inorganic anion exchanger activity;ion transmembrane transporter activity;protein binding;sodium:bicarbonate symporter activity;transporter activity anion transport;bicarbonate transport;cation transport;establishment of localization;inorganic anion transport;ion transport;metal ion transport;monovalent inorganic cation transport;organic anion transport;sodium ion transport;transport 4 4 4 5.2 5.2 5.2 136.04 8.8445E-69 37136000 19888000 17249000 1587 IPI:IPI00328342.8;IPI:IPI00021058.2;IPI:IPI00387156.5;IPI:IPI00719704.1;IPI:IPI00719757.1 Sodium bicarbonate cotransporter 3;Sodium bicarbonate cotransporter 2;Sodium bicarbonate cotransporter 2b;Solute carrier family 4 member 7 SLC4A7;BT;NBC2;NBC2B;NBC3;SBC2;SLC4A6 Q9Y6M7-1;Q9Y6M7;Q9Y6M7-3;Q9Y6M7-2;Q9Y6M7-4;Q9Y6M7-5 ENST00000295736;ENST00000349751;ENST00000388777 5 0.79432 1.6146 0.91742 1.0641 1.0285 1.1502 Aldo_ket_red cell part;cytoplasm;integral to membrane;intracellular part;intrinsic to membrane;membrane part binding;catalytic activity;cation channel activity;cation transmembrane transporter activity;ion channel activity;potassium channel activity;transporter activity;voltage-gated ion channel activity;voltage-gated potassium channel activity cation transport;establishment of localization;ion transport;metabolic process;metal ion transport;monovalent inorganic cation transport;oxidation reduction;potassium ion transport;transport 14 14 1 49.6 49.6 3.3 41 2.2406E-169 277400000 145850000 131560000 1589 IPI:IPI00021088.1;IPI:IPI00783784.1;IPI:IPI00783814.1;IPI:IPI00221124.2 Voltage-gated potassium channel subunit beta-2;K(+) channel subunit beta-2;Kv-beta-2;HKvbeta2 KCNAB2;KCNA2B;KCNK2 Q13303-1;Q13303 ENST00000164247;ENST00000341524;ENST00000352527;ENST00000378083;ENST00000378097 K04883 4 0.50538 1.2179 0.55453 0.69539 0.77836 0.73327 cell part;chromosomal part;chromosome, centromeric region;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;nucleus;organelle;organelle part cell cycle phase;cell cycle process;cell division;cellular component organization;cellular process;mitosis;nuclear division;organelle fission;organelle organization 3 3 3 23.6 23.6 23.6 25.863 4.9966E-17 42217000 20684000 21532000 1590 IPI:IPI00021095.1 Protein Mis18-alpha;FAPP1-associated protein 1 MIS18A;C21orf45;C21orf46;FASP1 Q9NYP9 ENST00000290130 K11564 1 NaN 1.6338 0.59322 NaN 1.0382 0.82353 Endonuclease_NS cell part;cytoplasmic part;intracellular organelle part;intracellular part;membrane;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part binding;catalytic activity;cation binding;endonuclease activity;hydrolase activity;hydrolase activity, acting on ester bonds;ion binding;metal ion binding;nuclease activity;nucleic acid binding Apoptosis 3 3 3 13.3 13.3 13.3 41.084 7.3516E-99 18037000 9253100 8783600 1591 IPI:IPI00021106.4;IPI:IPI00908995.2;IPI:IPI00024713.2 Nuclease EXOG, mitochondrial;Endonuclease G-like 1 ENDOGL1;ENDOGL2;ENGL;EXOG Q9Y2C4-1;Q9Y2C4 ENST00000287675;ENST00000358249 K01173 3 0.58966 1.2447 NaN 0.81748 0.79548 NaN FGGY_C;FGGY_N ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups;xylulokinase activity alcohol metabolic process;carbohydrate metabolic process;cellular metabolic process;cellular process;D-xylose metabolic process;generation of precursor metabolites and energy;metabolic process;monosaccharide metabolic process;pentose metabolic process Pentose and glucuronate interconversions 3 3 3 8 8 8 58.382 2.587E-09 13777000 7429800 6347600 1592 IPI:IPI00021107.7 Xylulose kinase XYLB O75191 ENST00000207870 K00854 1 NaN 1.7466 0.9527 NaN 1.085 1.2659 Miro cell part;cytoplasm;intracellular part binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleotide binding;pyrophosphatase activity cell communication;cellular process;I-kappaB kinase/NF-kappaB cascade;intracellular signaling cascade;protein kinase cascade;regulation of biological process;regulation of cellular process;signal transduction;small GTPase mediated signal transduction 3 3 3 17.8 17.8 17.8 21.508 7.2069E-11 26266000 13568000 12698000 1593 IPI:IPI00021124.3;IPI:IPI00738016.1 NF-kappa-B inhibitor-interacting Ras-like protein 2;I-kappa-B-interacting Ras-like protein 2 NKIRAS2;KBRAS2 Q9NYR9-1;Q9NYR9;Q9NYR9-2 ENST00000307641;ENST00000316082;ENST00000393880;ENST00000393881;ENST00000393884;ENST00000393885 2 0.71773 1.5968 0.5166 0.99612 1.056 0.68112 Adaptin_N clathrin coated vesicle membrane;coated vesicle membrane;cytoplasmic vesicle membrane;Golgi apparatus;intracellular organelle;macromolecular complex;membrane;membrane coat;membrane-bounded organelle;organelle;organelle membrane;vesicle membrane binding;enzyme binding;phosphatase binding;protein binding;protein phosphatase binding;protein transporter activity;substrate-specific transporter activity;transporter activity cellular component organization;cellular process;endocytosis;establishment of localization;membrane invagination;membrane organization;transport;vesicle-mediated transport 7 7 3 7.9 7.9 3.1 121.32 2.0793E-35 12306000 6897100 5408700 1594 IPI:IPI00021129.5 AP-3 complex subunit beta-1;Adapter-related protein complex 3 subunit beta-1;Adaptor protein complex AP-3 beta-1 subunit;Beta3A-adaptin;Clathrin assembly protein complex 3 beta-1 large chain AP3B1;ADTB3A O00203-1;O00203 ENST00000255194 K12397 1 NaN 1.7471 NaN NaN 1.1548 NaN Prp18;PRP4 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part;ribonucleoprotein complex;spliceosomal complex cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 4 3 3 10.8 9.1 9.1 39.859 3.9141E-07 3637000 2213800 1423200 1595 IPI:IPI00021146.1 Pre-mRNA-splicing factor 18;PRP18 homolog PRPF18;HPRP18 Q99633-1;Q99633 ENST00000298451;ENST00000378572 1 0.71228 1.5451 0.74934 0.91775 1.0171 0.99172 dsrm cell part;cytoplasm;intracellular part binding;double-stranded RNA binding;enzyme activator activity;enzyme regulator activity;identical protein binding;nucleic acid binding;protein binding;protein dimerization activity;protein homodimerization activity;RNA binding immune response;immune system process;metabolic process;negative regulation of cell proliferation;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to biotic stimulus;RNA processing 10 10 10 42.5 42.5 42.5 34.404 7.3464E-145 425000000 232620000 192380000 1597 IPI:IPI00021167.3;IPI:IPI00718940.1;IPI:IPI00719567.1 Interferon-inducible double stranded RNA-dependent protein kinase activator A;Protein kinase, interferon-inducible double stranded RNA-dependent activator;Protein activator of the interferon-induced protein kinase;PKR-associated protein X;PKR-associating protein X PRKRA;PACT;RAX;HSD14;HSD-14 O75569-1;O75569;O75569-2;O75569-3 ENST00000325748 3 0.83126 NaN NaN 1.1105 NaN NaN Alpha_adaptinC2;GAT;VHS AP-type membrane coat adaptor complex;clathrin adaptor complex;endosomal part;endosome membrane;Golgi apparatus part;intracellular part;macromolecular complex;membrane;membrane part;organelle membrane;organelle part;protein complex;trans-Golgi network ADP-ribosylation factor binding;binding;enzyme binding;GTPase binding;protein binding;small GTPase binding cellular process;establishment of localization;establishment of localization in cell;establishment of protein localization;intracellular protein transport;intracellular transport;protein transport;transport;vesicle-mediated transport 3 2 2 5.7 4.7 4.7 78.314 8.1222E-22 3966300 2177600 1788800 1598 IPI:IPI00021174.1;IPI:IPI00219305.1 ADP-ribosylation factor-binding protein GGA3;Golgi-localized, gamma ear-containing, ARF-binding protein 3 GGA3;KIAA0154 Q9NZ52-1;Q9NZ52 ENST00000245541;ENST00000351904 K12404 2 0.35854 0.74653 0.35985 0.48334 0.44934 0.46784 Pkinase cell part;intracellular organelle part;intracellular part;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part binding;catalytic activity;cyclin-dependent protein kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;RNA polymerase II transcription factor activity cellular biopolymer metabolic process;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process 6 5 4 5.2 4.6 3.5 164.15 6.8794E-20 35261000 20377000 14884000 1599 IPI:IPI00021175.1;IPI:IPI00868781.2 Cell division cycle 2-related protein kinase 7;Cdc2-related kinase, arginine/serine-rich CRKRS;CRK7;KIAA0904 Q9NYV4-1;Q9NYV4;Q9NYV4-2 ENST00000300647 K08819 2 0.72845 1.5425 0.74944 0.96705 0.98953 0.96302 AAA;TIP49 cytoplasm;H4/H2A histone acetyltransferase complex;histone acetyltransferase complex;intracellular part;macromolecular complex;membrane;NuA4 histone acetyltransferase complex;nuclear matrix;nuclear part;organelle part;protein complex ATP binding;binding;catalytic activity;DNA helicase activity;helicase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity chromatin organization;DNA metabolic process;DNA recombination;nuclear division;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription Wnt signaling pathway 26 26 26 60.3 60.3 60.3 50.227 0 2565200000 1409600000 1155700000 1600 IPI:IPI00021187.4;IPI:IPI00788942.1 RuvB-like 1;49 kDa TATA box-binding protein-interacting protein;TIP49a;Pontin 52;Nuclear matrix protein 238;54 kDa erythrocyte cytosolic protein;TIP60-associated protein 54-alpha;INO80 complex subunit H RUVBL1;INO80H;NMP238;TIP49;TIP49A Q9Y265-1;Q9Y265;Q9Y265-2 ENST00000322623 K04499 2 0.57232 1.0059 0.52885 0.77082 0.66826 0.69763 Pkinase;POLO_box centrosome;cytoplasmic part;cytoskeletal part;cytosol;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;microtubule organizing center;non-membrane-bounded organelle;nuclear part;nucleoplasm;organelle;organelle part catalytic activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;receptor signaling protein serine/threonine kinase activity;signal transducer activity cell proliferation;cellular component organization;cellular process;metabolic process;mitosis;nuclear division;organelle organization;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process Cell cycle;Progesterone-mediated oocyte maturation 15 15 15 34.5 34.5 34.5 68.254 2.3686E-240 123120000 67054000 56061000 1601 IPI:IPI00021248.1 Serine/threonine-protein kinase PLK1;Polo-like kinase 1;Serine/threonine-protein kinase 13 PLK1;PLK P53350 ENST00000300093 K06631 1 0.80275 1.6578 0.98259 1.1273 1.1013 1.2098 Arfaptin cell cortex;cell part;cell projection;cytoplasmic part;intracellular part;membrane;plasma membrane;ruffle binding;enzyme binding;GTP binding;GTP-dependent protein binding;guanyl nucleotide binding;nucleotide binding;protein binding;purine nucleotide binding;Ras GTPase binding;Rho GTPase binding;ribonucleotide binding;small GTPase binding anatomical structure formation;cell communication;cell motion;cellular component organization;cellular process;cytoskeleton organization;intracellular signaling cascade;organelle organization;signal transduction;small GTPase mediated signal transduction 6 6 6 17.3 17.3 17.3 37.855 2.642E-21 22169000 10961000 11208000 1602 IPI:IPI00021257.1 Arfaptin-2;ADP-ribosylation factor-interacting protein 2;Partner of RAC1 ARFIP2;POR1 P53365 ENST00000254584;ENST00000396777 1 0.78672 1.8444 0.84424 1.0915 1.0622 1.1427 14-3-3 cell part;cytoplasmic membrane-bounded vesicle;cytoplasmic part;cytoplasmic vesicle;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;melanosome;membrane-bounded organelle;membrane-bounded vesicle;organelle;vesicle binding;protein binding;transcription factor binding anti-apoptosis;cell communication;cellular process;negative regulation of apoptosis;negative regulation of programmed cell death;regulation of apoptosis;regulation of cell death;regulation of programmed cell death;signal transduction Cell cycle 23 21 21 63.7 63.7 63.7 27.745 0 8776100000 4545100000 4231000000 1603 IPI:IPI00021263.3 14-3-3 protein zeta/delta;Protein kinase C inhibitor protein 1 YWHAZ P63104 ENST00000353245;ENST00000395948;ENST00000395951;ENST00000395953;ENST00000395956;ENST00000395957;ENST00000395958 K06630 1 0.62047 1.4877 0.62575 0.88005 0.92947 0.89439 Ribosomal_L23;Ribosomal_L23eN cell part;cytoplasmic part;cytosolic large ribosomal subunit;cytosolic part;intracellular organelle part;intracellular part;large ribosomal subunit;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding;rRNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 13 13 13 46.8 46.8 46.8 17.695 9.9195E-208 4091800000 2240900000 1850900000 1604 IPI:IPI00021266.1 60S ribosomal protein L23a RPL23A P62750 ENST00000355731;ENST00000394938 K02893 1 0.79805 1.8256 0.67834 1.1219 1.1705 0.91439 ParA ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex assembly;cellular macromolecular complex subunit organization;cellular process;protein complex assembly;septin ring assembly 3 3 3 14.7 14.7 14.7 34.534 3.2033E-11 39764000 22279000 17485000 1605 IPI:IPI00021277.2;IPI:IPI00869040.2 Nucleotide-binding protein 1 NUBP1;NBP;NBP1 P53384-1;P53384;P53384-2 ENST00000283027 2 0.81204 1.4583 0.79144 1.0719 0.94279 1.0358 CoA_binding;Ligase_CoA cell part;citrate lyase complex;cytoplasmic part;cytosol;intracellular part;macromolecular complex;protein complex ATP binding;ATP citrate synthase activity;binding;catalytic activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;succinate-CoA ligase (ADP-forming) activity;succinate-CoA ligase activity ATP catabolic process;carbohydrate metabolic process;citrate metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;purine nucleotide catabolic process;purine nucleotide metabolic process Citrate cycle (TCA cycle);Reductive carboxylate cycle (CO2 fixation) 48 48 48 48 48 48 120.84 0 6376500000 3376400000 3000000000 1606 IPI:IPI00021290.5 ATP-citrate synthase;ATP-citrate (pro-S-)-lyase;Citrate cleavage enzyme ACLY P53396 ENST00000352035;ENST00000406400 K01648 1 0.35664 0.7882 NaN 0.52434 0.50255 NaN Cyclin_N cell part;cyclin-dependent protein kinase activating kinase holoenzyme complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;protein complex binding;protein binding DNA catabolic process;DNA metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleotide-excision repair, DNA damage removal;regulation of transcription, DNA-dependent;RNA elongation;transcription initiation Cell cycle;Nucleotide excision repair 6 6 6 23.2 23.2 23.2 37.643 1.6129E-30 12316000 6840500 5475000 1607 IPI:IPI00021305.1 Cyclin-H;MO15-associated protein;p37;p34 CCNH P51946 ENST00000256897 K06634 1 0.63636 1.3983 0.60268 0.86501 0.8667 0.80064 Bin3 catalytic activity;methyltransferase activity;transferase activity;transferase activity, transferring one-carbon groups 6 6 6 9.7 9.7 9.7 74.354 2.1703E-59 48579000 27371000 21208000 1608 IPI:IPI00021320.2 7SK snRNA methylphosphate capping enzyme;Bicoid-interacting protein 3 homolog MEPCE;BCDIN3 Q7L2J0 ENST00000310512 1 0.92759 1.4628 0.9193 1.2123 0.99836 1.1693 SH2;SH3_1 cell part;cytoplasmic part;cytosol;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle binding;epidermal growth factor receptor binding;insulin receptor substrate binding;molecular adaptor activity;molecular transducer activity;protein binding;protein binding, bridging;receptor binding;SH3/SH2 adaptor activity;signal transducer activity cell communication;cell surface receptor linked signal transduction;enzyme linked receptor protein signaling pathway;epidermal growth factor receptor signaling pathway;signal transduction;transmembrane receptor protein tyrosine kinase signaling pathway Acute myeloid leukemia;B cell receptor signaling pathway;Chemokine signaling pathway;Chronic myeloid leukemia;Colorectal cancer;Dorso-ventral axis formation;Endometrial cancer;ErbB signaling pathway;Fc epsilon RI signaling pathway;Focal adhesion;Gap junction;Glioma;GnRH signaling pathway;Insulin signaling pathway;Jak-STAT signaling pathway;MAPK signaling pathway;MAPK signaling pathway - fly;Natural killer cell mediated cytotoxicity;Non-small cell lung cancer;Pathways in cancer;Prostate cancer;Renal cell carcinoma;T cell receptor signaling pathway 13 13 13 61.8 61.8 61.8 25.206 1.9704E-56 1150900000 569340000 581610000 1609 IPI:IPI00021327.3;IPI:IPI00218070.1 Growth factor receptor-bound protein 2;Adapter protein GRB2;SH2/SH3 adapter GRB2;Protein Ash GRB2;ASH P62993-1;P62993;P62993-2 ENST00000316615;ENST00000316804;ENST00000392562;ENST00000392564 K04364 2 NaN 1.2664 NaN NaN 0.83361 NaN 3 3 3 10.5 10.5 10.5 38.121 0.0022362 7282200 3904100 3378000 1610 IPI:IPI00021329.3 WD repeat domain phosphoinositide-interacting protein 3;WD repeat-containing protein 45-like;WIPI49-like protein WDR45L;WIPI3 Q5MNZ6 ENST00000392325 1 0.74921 1.6356 0.7316 0.98072 1.054 0.95943 2-oxoacid_dh;Biotin_lipoyl;E3_binding cell part;cytoplasmic part;intracellular organelle part;intracellular part;macromolecular complex;mitochondrial part;mitochondrial pyruvate dehydrogenase complex;organelle part;protein complex;pyruvate dehydrogenase complex acetyltransferase activity;acyltransferase activity;binding;catalytic activity;dihydrolipoyllysine-residue acetyltransferase activity;protein binding;S-acetyltransferase activity;S-acyltransferase activity;transferase activity acetyl-CoA biosynthetic process;acetyl-CoA metabolic process;alcohol metabolic process;carbohydrate metabolic process;glucose catabolic process;glucose metabolic process;monosaccharide metabolic process;organic acid metabolic process Citrate cycle (TCA cycle);Glycolysis / Gluconeogenesis;Pyruvate metabolism 15 15 15 23.5 23.5 23.5 68.996 5.7549E-286 821420000 451460000 369960000 1611 IPI:IPI00021338.2 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial;Pyruvate dehydrogenase complex E2 subunit;Dihydrolipoamide S-acetyltransferase component of pyruvate dehydrogenase complex;70 kDa mitochondrial autoantigen of primary biliary cirrhosis;M2 antigen complex 70 kDa subunit DLAT;DLTA P10515 ENST00000280346 K00627 1 0.72766 1.6582 0.79493 1.0443 0.97398 1.0775 UQ_con cell part;cytoplasm;intracellular part;macromolecular complex;protein complex;ubiquitin ligase complex acid-amino acid ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;ubiquitin-protein ligase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;protein metabolic process;protein modification process;protein ubiquitination;proteolysis;regulation of metabolic process;ubiquitin-dependent protein catabolic process Parkinson's disease;Ubiquitin mediated proteolysis 8 8 8 55.2 55.2 55.2 17.861 2.5261E-144 999270000 534320000 464950000 1612 IPI:IPI00021347.1 Ubiquitin-conjugating enzyme E2 L3;Ubiquitin-protein ligase L3;Ubiquitin carrier protein L3;UbcH7;E2-F1;L-UBC UBE2L3;UBCE7;UBCH7 P68036 ENST00000342192 K04552 1 0.78533 1.3114 0.84013 1.0114 0.92447 1.073 UBA;UQ_con cell part;cytoplasm;intracellular part acid-amino acid ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;ubiquitin-protein ligase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;protein metabolic process;protein modification process;proteolysis;regulation of metabolic process;ubiquitin-dependent protein catabolic process 7 7 7 38.5 38.5 38.5 22.406 1.3794E-28 285520000 154600000 130920000 1613 IPI:IPI00021370.1;IPI:IPI00019894.3 Ubiquitin-conjugating enzyme E2 K;Ubiquitin-conjugating enzyme E2-25 kDa;Ubiquitin-protein ligase;Ubiquitin carrier protein;Huntingtin-interacting protein 2 UBE2K;HIP2;LIG P61086-1;P61086;P61086-2 ENST00000261427;ENST00000295963 2 1.1813 1.8878 1.1937 1.4691 1.3626 1.4779 HMA;Sod_Cu cell fraction;cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle;soluble fraction binding;cation transmembrane transporter activity;copper ion binding;copper ion transmembrane transporter activity;ion transmembrane transporter activity;protein binding;transporter activity;zinc ion binding cation transport;cellular process;copper ion transport;intracellular copper ion transport;ion transport;metabolic process;oxygen and reactive oxygen species metabolic process;superoxide metabolic process;transition metal ion transport;transport Amyotrophic lateral sclerosis (ALS) 3 3 3 13.1 13.1 13.1 29.04 5.9866E-08 35962000 18191000 17771000 1614 IPI:IPI00021389.1 Copper chaperone for superoxide dismutase;Superoxide dismutase copper chaperone CCS O14618 ENST00000310190 K04569 1 0.7553 1.3021 0.75025 0.99332 0.88293 1.0176 SART-1 cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;positive regulation of immune system process;positive regulation of leukocyte activation;regulation of immune system process;regulation of leukocyte activation;RNA processing 19 19 19 25 25 25 90.254 0 688030000 351110000 336920000 1615 IPI:IPI00021417.3 U4/U6.U5 tri-snRNP-associated protein 1;U4/U6.U5 tri-snRNP-associated 110 kDa protein;Squamous cell carcinoma antigen recognized by T cells 1 SART1 O43290 ENST00000312397 K11984 1 0.78617 1.5515 0.78449 1.0495 1.0146 1.0255 AAA cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;proteasome complex;protein complex ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Proteasome 31 31 31 71.1 71.1 71.1 48.633 0 3186800000 1679200000 1507500000 1616 IPI:IPI00021435.3 26S protease regulatory subunit 7;Proteasome 26S subunit ATPase 2;Protein MSS1 PSMC2;MSS1 P35998 ENST00000292644 K03061 1 0.84578 1.592 0.85774 1.1069 1.0628 1.0838 Actin cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle adenyl nucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;ribonucleotide binding;structural constituent of cytoskeleton;structural molecule activity cell motion;cellular process;cognition;multicellular organismal process;neurological system process;sensory perception;sensory perception of mechanical stimulus;sensory perception of sound;system process Adherens junction;Focal adhesion;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Tight junction;Vibrio cholerae infection 45 45 1 85.3 85.3 4.5 41.792 0 175190000000 90364000000 84823000000 1617 IPI:IPI00021440.1 Actin, cytoplasmic 2;Gamma-actin;Actin, cytoplasmic 2, N-terminally processed ACTG1;ACTB;ACTG P63261 ENST00000331925 K05692 1 0.73852 1.5795 0.75927 0.99293 0.99702 0.98072 RhoGAP;SH2;SH3_1 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex;cell part;cytoplasmic part;cytosolic part;intracellular part;macromolecular complex;phosphoinositide 3-kinase complex;protein complex binding;enzyme binding;insulin receptor binding;insulin-like growth factor receptor binding;kinase regulator activity;lipid binding;peptide hormone binding;phosphatidylinositol binding;phospholipid binding;protein binding;receptor binding cell communication;cell surface receptor linked signal transduction;glycerophospholipid metabolic process;lipid metabolic process;phosphate metabolic process;phospholipid metabolic process;phosphorus metabolic process;signal transduction Acute myeloid leukemia;Apoptosis;B cell receptor signaling pathway;Chemokine signaling pathway;Chronic myeloid leukemia;Colorectal cancer;Endometrial cancer;ErbB signaling pathway;Fc epsilon RI signaling pathway;Focal adhesion;Glioma;Insulin signaling pathway;Jak-STAT signaling pathway;Leukocyte transendothelial migration;Melanoma;mTOR signaling pathway;Natural killer cell mediated cytotoxicity;Non-small cell lung cancer;Pancreatic cancer;Pathways in cancer;Phosphatidylinositol signaling system;Progesterone-mediated oocyte maturation;Prostate cancer;Regulation of actin cytoskeleton;Renal cell carcinoma;Small cell lung cancer;T cell receptor signaling pathway;Toll-like receptor signaling pathway;Type II diabetes mellitus;VEGF signaling pathway 10 10 10 16.7 16.7 16.7 84.473 1.0696E-168 94437000 49767000 44671000 1619 IPI:IPI00807573.1;IPI:IPI00021448.2;IPI:IPI00295788.11;IPI:IPI00333040.5;IPI:IPI00011736.3;IPI:IPI00513745.1;IPI:IPI00220498.1;IPI:IPI00220499.1 Phosphatidylinositol 3-kinase regulatory subunit alpha;PI3-kinase p85 subunit alpha;PtdIns-3-kinase p85-alpha PIK3R1;GRB1 P27986-4;P27986;P27986-1;P27986-2;P27986-3 ENST00000274335;ENST00000320694;ENST00000336483;ENST00000396611 K02649 8 0.71654 1.6438 0.78964 1.0257 0.99482 1.1023 MIF4G;PAM2 cell part;cytoplasm;intracellular part binding;nucleic acid binding;protein binding;RNA binding;translation activator activity;translation factor activity, nucleic acid binding;translation regulator activity cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of biosynthetic process;regulation of translation;translational initiation 6 6 6 9.4 9.4 9.4 53.524 3.2627E-35 54135000 29722000 24413000 1621 IPI:IPI00021466.5;IPI:IPI00337775.3 Polyadenylate-binding protein-interacting protein 1 PAIP1 Q9H074-1;Q9H074;Q9H074-2 ENST00000306846 2 0.90397 NaN 0.63822 1.0821 NaN 0.81511 Ras cell part;cytoplasmic part;Golgi apparatus part;Golgi membrane;intracellular organelle part;intracellular part;membrane;organelle membrane;organelle part binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cell communication;cellular process;establishment of protein localization;intracellular signaling cascade;protein transport;regulation of biological process;signal transduction;small GTPase mediated signal transduction;transport 3 2 2 14.4 9.6 9.6 25.717 0.00052415 11321000 6016200 5304400 1622 IPI:IPI00021475.1 Ras-related protein Rab-33B RAB33B Q9H082 ENST00000305626 K07920 1 0.1333 24.077 1.0291 0.18855 14.325 1.4222 efhand binding;calcium ion binding;cation binding;ion binding;metal ion binding;protein binding anatomical structure development;biological regulation;cell communication;cellular process;developmental process;epidermis development;regulation of biological process;regulation of cellular process;signal transduction;tissue development Alzheimer's disease;Calcium signaling pathway;Glioma;GnRH signaling pathway;Insulin signaling pathway;Long-term potentiation;Melanogenesis;Olfactory transduction;Phosphatidylinositol signaling system;Vascular smooth muscle contraction + 5 5 5 30.8 30.8 30.8 15.892 7.4799E-74 156050000 105360000 50698000 1624 IPI:IPI00021536.2 Calmodulin-like protein 5;Calmodulin-like skin protein CALML5;CLSP Q9NZT1 ENST00000380332 K02183 1 0.88711 1.6358 0.92552 1.1095 1.1518 1.1305 Serpin cell part;cytoplasm;intracellular part endopeptidase inhibitor activity;enzyme inhibitor activity;enzyme regulator activity;peptidase inhibitor activity;serine-type endopeptidase inhibitor activity 3 3 3 8.2 8.2 8.2 42.904 4.2355E-05 36774000 19145000 17629000 1625 IPI:IPI00021555.1 Serpin B7;Megsin;TP55 SERPINB7 O75635 ENST00000336429;ENST00000398019 1 0.68323 1.9052 0.88471 0.95123 1.1869 1.149 Gaa1 cell part;cytoplasmic part;endoplasmic reticulum part;GPI-anchor transamidase complex;intracellular organelle part;intracellular part;macromolecular complex;membrane part;organelle part;protein complex binding;cytoskeletal protein binding;protein binding;tubulin binding anatomical structure formation;attachment of GPI anchor to protein;cellular component organization;cellular process;metabolic process;protein complex assembly;protein metabolic process;protein modification process;protein retention in ER lumen Glycosylphosphatidylinositol(GPI)-anchor biosynthesis 4 4 4 7.6 7.6 7.6 67.622 1.1954E-38 58183000 33731000 24452000 1626 IPI:IPI00021594.3;IPI:IPI00400944.5 Glycosylphosphatidylinositol anchor attachment 1 protein;GAA1 protein homolog GPAA1;GAA1 O43292-1;O43292;O43292-2 ENST00000355091;ENST00000361036 K05289 2 NaN 2.1053 NaN NaN 1.4411 NaN Golgi apparatus;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part 2 2 2 4.8 4.8 4.8 58.023 3.0828E-07 251700 146920 104780 1627 IPI:IPI00021595.2 Glucocorticoid-induced transcript 1 protein GLCCI1 Q86VQ1 ENST00000223145 1 0.75786 1.3266 0.82501 1.0218 0.87033 1.0836 RRM_1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;nucleotide binding;RNA binding 5 5 5 13.5 13.5 13.5 50.413 5.474E-32 100500000 54216000 46283000 1628 IPI:IPI00021626.2;IPI:IPI00074329.2;IPI:IPI00550442.1;IPI:IPI00929470.1 RNA-binding protein 42;RNA-binding motif protein 42 RBM42 Q9BTD8-1;Q9BTD8;Q9BTD8-3;Q9BTD8-2;Q9BTD8-4 ENST00000262633;ENST00000360475 4 0.47814 1.9825 NaN 0.63309 1.2244 NaN Rab5-bind;TPR_1 cell part;cytoplasmic part;cytoskeletal part;cytosol;intracellular organelle part;intracellular part;kinesin complex;macromolecular complex;microtubule;microtubule associated complex;organelle part;protein complex binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;microtubule motor activity;motor activity;protein binding;pyrophosphatase activity 10 5 4 18.6 9 7.1 68.934 9.8327E-75 10520000 6528200 3992100 1629 IPI:IPI00021634.3 Kinesin light chain 2 KLC2 Q9H0B6 ENST00000316924;ENST00000394067 1 0.7172 1.5353 0.7386 1.0162 0.89697 0.97834 Arf cell part;cytoplasm;intracellular part;membrane binding;cation binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;ion binding;magnesium ion binding;metal ion binding;nucleotide binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cell communication;determination of bilateral symmetry;determination of left/right symmetry;determination of symmetry;intracellular signaling cascade;pattern specification process;signal transduction;small GTPase mediated signal transduction;transport 2 2 2 11.8 11.8 11.8 21.097 0.0007007 10526000 5220800 5305400 1630 IPI:IPI00021685.1 ADP-ribosylation factor-like protein 6;Bardet-Biedl syndrome 3 protein ARL6 Q9H0F7 ENST00000335979;ENST00000394206 K07951 1 0.74563 1.471 0.70135 1.0131 0.92859 0.96128 zf-CCCH cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;double-stranded RNA binding;ion binding;metal ion binding;nucleic acid binding;RNA binding;transition metal ion binding;zinc ion binding anatomical structure morphogenesis;cell differentiation;cellular process;embryonic development;embryonic development ending in birth or egg hatching;embryonic limb morphogenesis;in utero embryonic development;nervous system development 4 4 1 10.1 10.1 2.8 41.817 7.5987E-14 639420000 344700000 294710000 1631 IPI:IPI00021692.2;IPI:IPI00218263.1;IPI:IPI00410205.1 Muscleblind-like protein 1;Triplet-expansion RNA-binding protein MBNL1;EXP;KIAA0428;MBNL Q9NR56-1;Q9NR56;Q9NR56-2;Q9NR56-3 ENST00000282486;ENST00000282488;ENST00000355460 3 0.75618 1.3038 0.68226 1.0904 0.78446 0.95324 Cation_ATPase_C;Cation_ATPase_N;E1-E2_ATPase;Hydrolase cell part;cytoplasm;integral to membrane;integral to plasma membrane;intracellular part;intrinsic to membrane;intrinsic to plasma membrane;membrane;membrane part;plasma membrane;plasma membrane part ATP binding;binding;calcium ion binding;calcium-transporting ATPase activity;calmodulin binding;catalytic activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;transporter activity ATP biosynthetic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;transport Calcium signaling pathway 6 2 2 5.9 1.9 1.9 138.75 9.9809E-58 8337100 3869100 4467900 1632 IPI:IPI00021695.1;IPI:IPI00216528.1;IPI:IPI00216527.1;IPI:IPI00216530.1;IPI:IPI00216526.1;IPI:IPI00216529.1;IPI:IPI00009791.1;IPI:IPI00219296.1;IPI:IPI00219297.1 Plasma membrane calcium-transporting ATPase 1;Plasma membrane calcium pump isoform 1;Plasma membrane calcium ATPase isoform 1;Plasma membrane calcium-transporting ATPase 2;Plasma membrane calcium ATPase isoform 2;Plasma membrane calcium pump isoform 2 ATP2B1;PMCA1;ATP2B2;PMCA2 P20020-1;P20020;P20020-4;P20020-3;P20020-6;P20020-2;P20020-5;Q01814-1;Q01814;Q01814-5;Q01814-6 ENST00000261173;ENST00000348959;ENST00000359142;ENST00000393164;ENST00000342354;ENST00000343816;ENST00000352432;ENST00000360273 K05850 9 0.7172 1.3042 0.73167 0.92543 0.85456 0.94043 PCNA_C;PCNA_N cell part;chromosomal part;DNA replication factor C complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;PCNA complex;protein complex binding;catalytic activity;DNA binding;double-stranded DNA binding;hydrolase activity;mismatch base pair DNA N-glycosylase activity;nucleic acid binding;protein binding;purine-specific mismatch base pair DNA N-glycosylase activity DNA metabolic process;DNA repair;mismatch repair;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleotide-excision repair, DNA gap filling;regulation of DNA replication;response to stress Base excision repair;Cell cycle;DNA replication;Mismatch repair;Nucleotide excision repair 18 18 18 74.7 74.7 74.7 28.768 0 6465200000 3436600000 3028600000 1633 IPI:IPI00021700.3 Proliferating cell nuclear antigen;Cyclin PCNA P12004 ENST00000379143;ENST00000379160 K04802 1 0.67876 1.2262 0.67307 0.86898 0.77532 0.89222 eIF-5_eIF-2B cell part;cytoplasmic part;cytosol;eukaryotic translation initiation factor 2 complex;intracellular part;macromolecular complex;protein complex binding;cation binding;ion binding;metal ion binding;nucleic acid binding;protein binding;RNA binding;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity;zinc ion binding cellular process;translational initiation 13 13 13 34.8 34.8 34.8 38.388 3.374E-219 983280000 519190000 464090000 1634 IPI:IPI00021728.3;IPI:IPI00176637.5 Eukaryotic translation initiation factor 2 subunit 2;Eukaryotic translation initiation factor 2 subunit beta;Eukaryotic translation initiation factor 2 subunit 2-like protein EIF2S2;EIF2B P20042;A6NK07 ENST00000374980;ENST00000249480 K03238 2 0.78863 1.5774 0.84642 1.0381 1.0386 1.0578 Reticulon envelope;integral to endoplasmic reticulum membrane;integral to membrane;integral to organelle membrane;intrinsic to endoplasmic reticulum membrane;intrinsic to membrane;intrinsic to organelle membrane;nuclear envelope;organelle envelope;organelle part binding;protein binding apoptosis;cell death;cellular process;death;negative regulation of cell development;programmed cell death;regulation of cell death;regulation of cell morphogenesis involved in differentiation;regulation of neuron projection development 6 6 6 8.1 8.1 8.1 129.93 1.9545E-125 707200000 366820000 340380000 1635 IPI:IPI00021766.5;IPI:IPI00894213.1;IPI:IPI00477663.1;IPI:IPI00478442.3;IPI:IPI00298289.1;IPI:IPI00219207.1 Reticulon-4;Neurite outgrowth inhibitor;Foocen;Neuroendocrine-specific protein;Neuroendocrine-specific protein C homolog;RTN-x;Reticulon-5 RTN4;KIAA0886;NOGO;My043;SP1507 Q9NQC3-1;Q9NQC3;Q9NQC3-6;Q9NQC3-4;Q9NQC3-5;Q9NQC3-2 ENST00000317610;ENST00000337526;ENST00000354474;ENST00000394609 6 0.73714 1.5212 0.82378 0.97517 0.9928 1.1575 COX5B cell part;cytoplasmic part;intracellular organelle part;intracellular part;membrane;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part binding;catalytic activity;cation transmembrane transporter activity;cytochrome-c oxidase activity;heme-copper terminal oxidase activity;ion transmembrane transporter activity;transporter activity;zinc ion binding multicellular organismal process;respiratory gaseous exchange Alzheimer's disease;Cardiac muscle contraction;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 6 6 6 30.2 30.2 30.2 13.696 5.5133E-90 636040000 340350000 295690000 1636 IPI:IPI00021785.2 Cytochrome c oxidase subunit 5B, mitochondrial;Cytochrome c oxidase polypeptide Vb COX5B P10606 ENST00000258424 K02265 1 0.71489 0.83659 NaN 0.96365 0.56345 NaN C1_1;Pkinase;RBD cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;membrane;mitochondrial membrane;mitochondrial outer membrane;mitochondrial part;organelle membrane;organelle outer membrane;organelle part;outer membrane;plasma membrane ATP binding;binding;catalytic activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;receptor signaling protein activity;signal transducer activity apoptosis;cell communication;intracellular signaling cascade;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;signal transduction;small GTPase mediated signal transduction Acute myeloid leukemia;B cell receptor signaling pathway;Bladder cancer;Chemokine signaling pathway;Chronic myeloid leukemia;Colorectal cancer;Endometrial cancer;ErbB signaling pathway;Fc epsilon RI signaling pathway;Focal adhesion;Gap junction;Glioma;GnRH signaling pathway;Insulin signaling pathway;Long-term depression;Long-term potentiation;MAPK signaling pathway;Melanogenesis;Melanoma;mTOR signaling pathway;Natural killer cell mediated cytotoxicity;Non-small cell lung cancer;Pancreatic cancer;Pathways in cancer;Progesterone-mediated oocyte maturation;Prostate cancer;Regulation of actin cytoskeleton;Renal cell carcinoma;T cell receptor signaling pathway;Thyroid cancer;Vascular smooth muscle contraction;VEGF signaling pathway 6 2 2 10 3.4 3.4 75.394 2.399E-17 4866200 2787900 2078300 1637 IPI:IPI00900312.1;IPI:IPI00021786.1;IPI:IPI00303797.3 RAF proto-oncogene serine/threonine-protein kinase;C-RAF;Raf-1;B-Raf proto-oncogene serine/threonine-protein kinase;p94;v-Raf murine sarcoma viral oncogene homolog B1 RAF1;RAF;BRAF;BRAF1;RAFB1 P04049-2;P04049;P04049-1;P15056 ENST00000251849;ENST00000288602 K04366;K04365 3 0.74279 1.5514 0.69731 0.98754 1.0318 0.93772 Peptidase_S10 cell part;cytoplasmic part;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;lysosome;lytic vacuole;membrane-bounded organelle;organelle;vacuole binding;carboxypeptidase activity;catalytic activity;enzyme activator activity;exopeptidase activity;hydrolase activity;peptidase activity;protein binding;serine hydrolase activity;serine-type carboxypeptidase activity;serine-type peptidase activity biopolymer metabolic process;catabolic process;intracellular protein transport;macromolecule catabolic process;macromolecule metabolic process;metabolic process;protein catabolic process;protein metabolic process;protein transport;proteolysis;transport Renin-angiotensin system 4 4 4 9.2 9.2 9.2 54.465 3.0101E-14 90273000 49646000 40627000 1638 IPI:IPI00021794.8 Lysosomal protective protein;Cathepsin A;Carboxypeptidase C;Protective protein for beta-galactosidase;Lysosomal protective protein 32 kDa chain;Lysosomal protective protein 20 kDa chain CTSA;PPGB P10619 ENST00000191018;ENST00000354880;ENST00000372471;ENST00000372484 K01287 1 0.78709 1.6838 0.73541 0.98621 1.1261 0.95273 HGTP_anticodon;tRNA-synt_2b;WHEP-TRS cell part;cytoplasm;intracellular part aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;histidine-tRNA ligase activity;ligase activity;ligase activity, forming carbon-oxygen bonds;nucleoside binding;nucleotide binding;purine nucleoside binding cellular amino acid and derivative metabolic process;histidyl-tRNA aminoacylation;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;tRNA aminoacylation for protein translation;tRNA metabolic process Aminoacyl-tRNA biosynthesis;Histidine metabolism 29 29 22 57.4 57.4 43.6 57.41 0 1909100000 1040700000 868430000 1640 IPI:IPI00021808.3 Histidyl-tRNA synthetase, cytoplasmic;Histidine--tRNA ligase HARS;HRS P12081 ENST00000307633 K01892 1 0.47223 NaN 0.72001 0.75427 NaN 0.97456 CheC;PDZ cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding anatomical structure development;developmental process;nervous system development;system development 4 4 4 1 1 1 629.09 0.0019242 1101000 739160 361870 1641 IPI:IPI00021812.2 Neuroblast differentiation-associated protein AHNAK;Desmoyokin AHNAK;PM227 Q09666 ENST00000378024 1 0.94626 1.6232 0.93204 1.1528 1.1477 1.2035 Cystatin cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cysteine-type endopeptidase inhibitor activity;endopeptidase inhibitor activity;enzyme binding;enzyme inhibitor activity;enzyme regulator activity;peptidase inhibitor activity;protease binding;protein binding negative regulation of catalytic activity;negative regulation of hydrolase activity;negative regulation of molecular function;negative regulation of peptidase activity;regulation of catalytic activity;regulation of hydrolase activity 4 4 4 70.4 70.4 70.4 11.139 1.4936E-145 4597100000 2332100000 2265000000 1642 IPI:IPI00021828.1 Cystatin-B;Stefin-B;Liver thiol proteinase inhibitor;CPI-B CSTB;CST6;STFB P04080 ENST00000291568 1 1.5178 2.4362 1.4737 1.9545 1.6334 1.9727 cNMP_binding;RIIa cAMP-dependent protein kinase complex;cell part;intracellular part;macromolecular complex;protein complex AMP binding;binding;cAMP-dependent protein kinase regulator activity;kinase regulator activity;nucleoside binding;nucleotide binding;protein binding;protein kinase regulator activity;purine nucleoside binding;purine nucleotide binding cell communication;intracellular signaling cascade;regulation of protein amino acid phosphorylation;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;response to endogenous stimulus;signal transduction Apoptosis;Insulin signaling pathway 14 14 11 38.6 38.6 32.8 42.981 6.6756E-123 1143100000 638490000 504580000 1643 IPI:IPI00021831.1 cAMP-dependent protein kinase type I-alpha regulatory subunit;Tissue-specific extinguisher 1 PRKAR1A;PKR1;PRKAR1;TSE1 P10644 ENST00000358598;ENST00000392710;ENST00000392711 K04739 1 0.64692 1.3597 0.73849 0.93063 0.86254 0.97013 Ribosomal_S6e cytosolic small ribosomal subunit;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nucleolus;organelle;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit binding;protein binding;structural constituent of ribosome;structural molecule activity cell communication;intracellular signaling cascade;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA processing;rRNA processing;signal transduction;translational elongation Insulin signaling pathway;mTOR signaling pathway;Ribosome 14 14 14 35.7 35.7 35.7 28.68 0 5870100000 3123000000 2747200000 1644 IPI:IPI00021840.1 40S ribosomal protein S6;Phosphoprotein NP33 RPS6;OK/SW-cl.2 P62753 ENST00000380394 K02991 1 0.8415 1.5935 0.72473 1.1065 1.0933 0.91109 adh_short catalytic activity;estradiol 17-beta-dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;steroid dehydrogenase activity biosynthetic process;cellular process;estrogen biosynthetic process;estrogen metabolic process;lipid biosynthetic process;lipid metabolic process;metabolic process;regulation of hormone levels;steroid biosynthetic process;steroid metabolic process Androgen and estrogen metabolism 4 4 4 20.3 20.3 20.3 26.973 1.6376E-19 19486000 10209000 9276500 1645 IPI:IPI00021890.1 Estradiol 17-beta-dehydrogenase 8;Testosterone 17-beta-dehydrogenase 8;17-beta-hydroxysteroid dehydrogenase 8;Protein Ke6 HSD17B8;FABGL;HKE6;RING2 Q92506 ENST00000230236;ENST00000374662;ENST00000383080 K00044 1 0.8841 2.4854 1.1736 1.1742 1.5858 1.4682 Myelin_MBP cell part;membrane part;myelin sheath;plasma membrane part structural constituent of myelin sheath;structural molecule activity anatomical structure development;cell communication;cell-cell signaling;cellular process;central nervous system development;developmental process;immune response;immune system process;response to stimulus;synaptic transmission;system development 2 2 2 10.2 10.2 10.2 33.117 0.00076256 64049000 31590000 32460000 1646 IPI:IPI00021907.2;IPI:IPI00216474.1;IPI:IPI00216475.3;IPI:IPI00607642.1;IPI:IPI00216477.1;IPI:IPI00216478.1 Myelin basic protein;Myelin A1 protein;Myelin membrane encephalitogenic protein MBP P02686-1;P02686;P02686-2;P02686-3;P02686-4;P02686-5;P02686-6 ENST00000355994;ENST00000359645;ENST00000382582 6 0.8893 1.4167 0.87426 1.1968 0.93792 1.154 Linker_histone cell part;chromosomal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;macromolecular complex;membrane-bounded organelle;nucleosome;nucleus;organelle;organelle part;protein-DNA complex binding;DNA binding;nucleic acid binding anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;chromatin organization;nucleosome assembly;organelle organization 5 5 5 18.3 18.3 18.3 22.487 2.9121E-32 357870000 168210000 189660000 1647 IPI:IPI00021924.1 Histone H1x H1FX Q92522 ENST00000333762 K11275 1 0.9251 1.7702 0.89403 1.159 1.1957 1.1528 AAA cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;proteasome complex;protein complex ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Proteasome 19 19 19 51.2 51.2 51.2 44.172 1.9233E-270 1601500000 839670000 761780000 1648 IPI:IPI00021926.4 26S protease regulatory subunit S10B;Proteasome 26S subunit ATPase 6;Proteasome subunit p42 PSMC6;SUG2 P62333 ENST00000216407 K03064 1 0.8706 1.7663 0.82085 1.1368 1.1497 1.1127 Sec7 cell part;cytoplasmic part;Golgi apparatus part;Golgi membrane;intracellular organelle part;intracellular part;membrane;organelle membrane;organelle part ARF guanyl-nucleotide exchange factor activity;binding;enzyme regulator activity;GTPase regulator activity;guanyl-nucleotide exchange factor activity;nucleoside-triphosphatase regulator activity;protein binding;small GTPase regulator activity cellular component organization;cellular process;organelle organization;regulation of cell communication;regulation of signal transduction;retrograde vesicle-mediated transport, Golgi to ER;transport;vesicle coating;vesicle organization 25 24 24 15.5 15.2 15.2 206.44 2.2229E-99 257140000 132140000 125000000 1649 IPI:IPI00021954.1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 GBF1;KIAA0248 Q92538 ENST00000369983 1 1.1164 1.6198 0.95777 1.3752 1.1219 1.2407 PEX11 integral to membrane;integral to organelle membrane;integral to peroxisomal membrane;intracellular part;intrinsic to membrane;intrinsic to organelle membrane;intrinsic to peroxisomal membrane;membrane part;microbody part;organelle part;peroxisomal part binding;protein binding biological regulation;cell communication;cellular component organization;cellular process;organelle fission;organelle organization;peroxisome fission;regulation of biological process;regulation of cellular process;signal transduction 10 10 10 36.7 36.7 36.7 28.431 7.7691E-87 225690000 118830000 106860000 1650 IPI:IPI00021978.1 Peroxisomal membrane protein 11B;Peroxin-11B;Peroxisomal biogenesis factor 11B;PEX11beta;Pex11pbeta PEX11B O96011 ENST00000369306 1 1.0944 2.3395 0.9339 1.4204 1.6145 1.246 Nicastrin cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;endoplasmic reticulum;Golgi apparatus;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;melanosome;membrane-bounded vesicle;organelle;vesicle binding;protein binding catabolic process;cellular process;glycoprotein catabolic process;glycoprotein metabolic process;macromolecule catabolic process;membrane protein ectodomain proteolysis;metabolic process;Notch receptor processing;protein processing;proteolysis Alzheimer's disease;Notch signaling pathway 4 4 4 5.4 5.4 5.4 78.41 3.8271E-16 98516000 52444000 46073000 1651 IPI:IPI00021983.1;IPI:IPI00375688.1 Nicastrin NCSTN;KIAA0253;UNQ1874/PRO4317 Q92542-1;Q92542;Q92542-2 ENST00000294785;ENST00000392212 K06171 2 1.0824 2.1283 1.0348 1.4475 1.3456 1.3856 EMP70 cell part;integral to membrane;intrinsic to membrane;membrane part 7 7 7 13.1 13.1 13.1 74.518 1.1699E-62 100770000 48227000 52538000 1652 IPI:IPI00021985.4 Transmembrane 9 superfamily member 4 TM9SF4;KIAA0255 Q92544 ENST00000217315;ENST00000398022 1 1.0604 2.323 1.0359 1.4387 1.5976 1.4025 Glycos_transf_2 cell fraction;dolichol-phosphate-mannose synthase complex;endoplasmic reticulum membrane;insoluble fraction;intracellular part;macromolecular complex;mannosyltransferase complex;membrane;membrane fraction;organelle membrane;organelle part;protein complex binding;catalytic activity;dolichyl-phosphate beta-D-mannosyltransferase activity;dolichyl-phosphate-mannose-protein mannosyltransferase activity;mannosyltransferase activity;protein binding;transferase activity alcohol metabolic process;carbohydrate metabolic process;GPI anchor biosynthetic process;GPI anchor metabolic process;protein amino acid glycosylation;protein amino acid lipidation;protein amino acid O-linked glycosylation;protein modification process N-Glycan biosynthesis 11 11 11 42.3 42.3 42.3 29.634 6.7299E-130 742080000 356320000 385760000 1653 IPI:IPI00022018.1 Dolichol-phosphate mannosyltransferase;Dolichol-phosphate mannose synthase;Dolichyl-phosphate beta-D-mannosyltransferase;Mannose-P-dolichol synthase DPM1 O60762 ENST00000371584;ENST00000371588 K00721 1 NaN NaN 0.70064 NaN NaN 0.92834 Avl9 cell part;integral to membrane;intrinsic to membrane;membrane part 2 2 2 3.4 3.4 3.4 71.947 7.5192E-09 9023700 5002900 4020800 1657 IPI:IPI00397348.5;IPI:IPI00022042.2 Late secretory pathway protein AVL9 homolog AVL9;KIAA0241 Q8NBF6-1;Q8NBF6;Q8NBF6-2 ENST00000318709;ENST00000329714 2 0.70821 1.62 0.92801 0.96003 1.0482 1.2199 Hamartin cell cortex;cell fraction;cell part;cell projection;cytoplasmic part;cytosolic part;insoluble fraction;intracellular part;lamellipodium;macromolecular complex;membrane;membrane fraction;protein complex;TSC1-TSC2 complex binding;chaperone binding;protein binding;protein N-terminus binding cell adhesion;cell cycle;cell-matrix adhesion;nucleocytoplasmic transport;positive regulation of cell-matrix adhesion;regulation of cell-matrix adhesion;regulation of translation;RNA export from nucleus;rRNA export from nucleus;transport Insulin signaling pathway;mTOR signaling pathway 2 2 2 2.8 2.8 2.8 129.77 2.4122E-26 5260500 2861000 2399500 1658 IPI:IPI00022043.1 Hamartin;Tuberous sclerosis 1 protein TSC1;KIAA0243;TSC Q92574 ENST00000298552 K07206 1 NaN 2.4417 1.4165 NaN 1.6969 1.8012 Septin cell cortex part;cell part;cytoplasmic part;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;organelle part;protein complex;septin complex binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;protein binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cell cycle;cellular process 6 2 2 14.1 5.2 5.2 55.756 1.2952E-25 12696000 6529400 6166400 1660 IPI:IPI00549434.2;IPI:IPI00022082.7;IPI:IPI00787280.1;IPI:IPI00873459.3;IPI:IPI00374970.4 Septin-8 SEPT8;KIAA0202 Q92599-1;Q92599;Q92599-2;Q92599-3 ENST00000296873;ENST00000378721 5 0.5797 1.5752 0.57493 0.74779 1.0066 0.75759 TPR_1 centrosome;cytosol;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;microtubule;microtubule organizing center;non-membrane-bounded organelle;nuclear part;nucleoplasm;organelle;organelle part;spindle microtubule binding catabolic process;cell proliferation;macromolecule catabolic process;metabolic process;mitosis;nuclear division;organelle organization;proteolysis;regulation of mitosis;regulation of mitotic cell cycle;ubiquitin-dependent protein catabolic process Cell cycle;Cell cycle - yeast;Progesterone-mediated oocyte maturation;Ubiquitin mediated proteolysis 7 7 7 11.5 11.5 11.5 71.655 2.564E-20 36268000 20621000 15648000 1661 IPI:IPI00022091.3;IPI:IPI00376312.1;IPI:IPI00376313.1 Cell division cycle protein 16 homolog;CDC16Hs;Anaphase-promoting complex subunit 6;Cyclosome subunit 6 CDC16;ANAPC6 Q13042-1;Q13042;Q13042-2;Q13042-3 ENST00000252457;ENST00000356221;ENST00000360383;ENST00000375312 K03353 3 0.5815 1.2179 0.58324 0.75482 0.79633 0.74183 C2 cell part;integral to membrane;intrinsic to membrane;membrane part 27 27 27 32.4 32.4 32.4 124 0 866170000 480390000 385780000 1662 IPI:IPI00746655.1;IPI:IPI00022143.3 Extended synaptotagmin-1;Membrane-bound C2 domain-containing protein;Protein FAM62A FAM62A;ESYT1;KIAA0747;MBC2 Q9BSJ8-2;Q9BSJ8;Q9BSJ8-1 ENST00000267113;ENST00000394048;ENST00000402331 2 NaN NaN 1.1249 NaN NaN 1.8025 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 2 2 2 7.4 7.4 7.4 27.296 1.2326E-37 19281000 9170200 10111000 1663 IPI:IPI00022145.6;IPI:IPI00844197.1 Nuclear ubiquitous casein and cyclin-dependent kinases substrate;P1 NUCKS1;NUCKS Q9H1E3-1;Q9H1E3;Q9H1E3-2 ENST00000264531;ENST00000367141;ENST00000367142 2 0.57308 1.3434 0.7411 0.76858 0.88682 0.96059 PIP5K cell part;cytoplasmic part;endomembrane system;Golgi apparatus part;Golgi stack;intracellular organelle part;intracellular part;membrane;organelle part;plasma membrane ATP binding;binding;catalytic activity;inositol or phosphatidylinositol kinase activity;kinase activity;lipid kinase activity;nucleoside binding;nucleotide binding;phosphatidylinositol phosphate kinase activity;purine nucleoside binding cell communication;cellular process;glycerophospholipid metabolic process;lipid metabolic process;metabolic process;phosphate metabolic process;phospholipid metabolic process;phosphorus metabolic process;phosphorylation;signal transduction 6 6 3 14.2 14.2 7.8 62.633 7.1503E-67 3665000 2079500 1585500 1664 IPI:IPI00022150.1;IPI:IPI00163602.1;IPI:IPI00022149.1;IPI:IPI00029009.4;IPI:IPI00304025.2;IPI:IPI00465236.2 Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha;Phosphatidylinositol-4-phosphate 5-kinase type I alpha;68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha PIP5K1A Q99755-1;Q99755;Q99755-3;Q99755-2 ENST00000349792;ENST00000368888;ENST00000368890 6 NaN 2.4524 NaN NaN 1.5376 NaN PDZ;RGS-like;RhoGEF cell part;cytoplasm;intracellular part;membrane binding;G-protein-coupled receptor binding;GTPase activator activity;guanyl-nucleotide exchange factor activity;Ras guanyl-nucleotide exchange factor activity;receptor binding;Rho guanyl-nucleotide exchange factor activity;small GTPase regulator activity cell communication;cell surface receptor linked signal transduction;cellular process;G-protein coupled receptor protein signaling pathway;intracellular signaling cascade;regulation of signal transduction;signal transduction Axon guidance;Vascular smooth muscle contraction 3 3 3 2.6 2.6 2.6 173.23 0.00025155 337140 251330 85804 1665 IPI:IPI00022164.3;IPI:IPI00339353.3 Rho guanine nucleotide exchange factor 12;Leukemia-associated RhoGEF ARHGEF12;KIAA0382;LARG Q9NZN5-1;Q9NZN5;Q9NZN5-2 ENST00000356641;ENST00000397843 K07532 2 0.9624 1.4873 0.98734 1.1966 0.98456 1.2301 PUF cell part;cytoplasm;intracellular part binding;nucleic acid binding;protein binding;RNA binding posttranscriptional regulation of gene expression;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of metabolic process;regulation of translation 9 6 6 12.2 9 9 114.21 1.7279E-148 127910000 63466000 64442000 1666 IPI:IPI00398749.1;IPI:IPI00022184.1;IPI:IPI00398750.1 Pumilio homolog 2 PUM2;KIAA0235;PUMH2 Q8TB72-1;Q8TB72;Q8TB72-3;Q8TB72-2 ENST00000319801;ENST00000338086;ENST00000361078 3 0.74355 1.4552 0.75237 0.95237 0.97752 0.9628 Mito_carr integral to membrane;integral to plasma membrane;intracellular part;intrinsic to membrane;intrinsic to plasma membrane;membrane;membrane part;mitochondrial inner membrane;mitochondrial membrane;organelle inner membrane;organelle membrane;organelle part anion transmembrane transporter activity;binding;inorganic anion transmembrane transporter activity;ion transmembrane transporter activity;phosphate transmembrane transporter activity;transporter activity cellular metabolic process;cellular process;establishment of localization;generation of precursor metabolites and energy;metabolic process;transport 14 14 14 35.6 35.6 35.6 40.094 5.2646E-180 3596000000 1919800000 1676200000 1667 IPI:IPI00022202.3;IPI:IPI00215777.1 Phosphate carrier protein, mitochondrial;Phosphate transport protein;Solute carrier family 25 member 3 SLC25A3;PHC;OK/SW-cl.48 Q00325-1;Q00325;Q00325-2 ENST00000188376;ENST00000228318;ENST00000401722 2 NaN 4.6277 0.12405 NaN 2.8101 0.15648 Serpin cell part;cytoplasm;intracellular part binding;endopeptidase inhibitor activity;enzyme inhibitor activity;enzyme regulator activity;peptidase inhibitor activity;protein binding;serine-type endopeptidase inhibitor activity immune response;immune system process;regulation of catabolic process;regulation of cellular metabolic process;regulation of cellular protein metabolic process;regulation of metabolic process;regulation of proteolysis 9 9 9 19.7 19.7 19.7 44.564 4.0317E-64 44548000 39883000 4664400 1668 IPI:IPI00022204.2;IPI:IPI00307466.2;IPI:IPI00010303.1 Serpin B3;Squamous cell carcinoma antigen 1;Protein T4-A;Serpin B4;Squamous cell carcinoma antigen 2;Leupin SERPINB3;SCCA;SCCA1;SERPINB4;SCCA2 P29508-1;P29508;P29508-2;P48594 ENST00000341074;ENST00000356424;ENST00000283752 3 0.77965 1.2898 0.69982 1.039 0.83881 0.93075 Homeobox;zf-C2H2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;sequence-specific DNA binding;transcription factor activity;transcription regulator activity;transition metal ion binding;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 10 10 10 12.4 12.4 12.4 123.56 4.7527E-157 98743000 49125000 49617000 1669 IPI:IPI00022215.1 Activity-dependent neuroprotector homeobox protein;Activity-dependent neuroprotective protein ADNP;ADNP1;KIAA0784 Q9H2P0 ENST00000349014;ENST00000371602;ENST00000396029;ENST00000396032 1 0.83812 1.659 NaN 1.034 1.1073 NaN Cactin_mid;CactinC_cactus cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;protein binding cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 6 6 6 10.7 10.7 10.7 99.474 2.6932E-88 18786000 10409000 8377100 1670 IPI:IPI00022225.3;IPI:IPI00736681.2 Uncharacterized protein C19orf29;Renal carcinoma antigen NY-REN-24 C19orf29 Q8WUQ7-2;Q8WUQ7;Q8WUQ7-1 ENST00000221899;ENST00000248420 2 0.90105 1.5776 0.89909 1.1911 1.0534 1.1786 KH_1 cytoplasm;high-density lipoprotein particle;intracellular membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane;membrane-bounded organelle;nucleus;organelle;plasma lipoprotein particle;plasma membrane;protein-lipid complex binding;lipid binding;nucleic acid binding;protein binding;RNA binding alcohol metabolic process;biosynthetic process;cellular metabolic process;cellular process;cholesterol metabolic process;lipid metabolic process;lipid transport;metabolic process;steroid metabolic process;sterol metabolic process;transport 34 34 34 28.7 28.7 28.7 141.45 9.8808E-289 949090000 486420000 462670000 1671 IPI:IPI00022228.2 Vigilin;High density lipoprotein-binding protein HDLBP;HBP;VGL Q00341 ENST00000310931;ENST00000391975;ENST00000391976 1 1.0409 1.9827 1.1173 1.2291 1.2685 1.3596 DUF1081;DUF1943;Vitellogenin_N cell fraction;clathrin coated vesicle membrane;coated vesicle membrane;cytoplasmic vesicle membrane;endoplasmic reticulum lumen;endosome membrane;insoluble fraction;membrane;membrane fraction;microsome;plasma membrane;vesicle membrane binding;cholesterol transporter activity;glycosaminoglycan binding;heparin binding;lipid binding;lipid transporter activity;pattern binding;phospholipid binding;protein binding;receptor binding;sterol transporter activity;transporter activity alcohol metabolic process;lipid metabolic process;lipid transport;metabolic process;positive regulation of myeloid leukocyte differentiation;regulation of immune system process;regulation of myeloid leukocyte differentiation;transport 6 5 5 1.1 0.9 0.9 515.56 0.00015882 124830000 62476000 62353000 1672 IPI:IPI00022229.1;IPI:REV_IPI00217605.2 Apolipoprotein B-100;Apolipoprotein B-48 APOB P04114 ENST00000233242 2 0.77959 1.5111 0.73184 1.0381 0.99518 1.0042 Peptidase_M24 cell part;cytoplasm;intracellular part aminopeptidase activity;binding;catalytic activity;cation binding;exopeptidase activity;hydrolase activity;ion binding;metal ion binding;metalloexopeptidase activity;metallopeptidase activity;peptidase activity;protein binding;transition metal ion binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;protein modification process;proteolysis;regulation of biosynthetic process;regulation of gene expression;regulation of translation 11 11 11 42.5 42.5 42.5 43.215 1.6733E-108 603400000 326600000 276800000 1673 IPI:IPI00022239.7 Methionine aminopeptidase 1;Peptidase M 1 METAP1;KIAA0094 P53582 ENST00000296411 K01265 1 0.96889 1.4737 0.83697 1.3327 0.9438 1.1175 NifU_N cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;nucleus;organelle binding;cation binding;ion binding;iron ion binding;iron-sulfur cluster binding;metal cluster binding;metal ion binding;protein binding;protein complex scaffold;structural molecule activity;transition metal ion binding biosynthetic process;cellular biosynthetic process;cellular metabolic process;cellular process;cofactor metabolic process;iron-sulfur cluster assembly;metabolic process;metallo-sulfur cluster assembly;nitrogen compound metabolic process;nitrogen fixation 2 2 2 12 12 12 17.937 7.2635E-31 56220000 27592000 28628000 1674 IPI:IPI00022240.3;IPI:IPI00164885.1 Iron-sulfur cluster assembly enzyme ISCU, mitochondrial;NifU-like N-terminal domain-containing protein ISCU;NIFUN Q9H1K1-1;Q9H1K1;Q9H1K1-2 ENST00000311893;ENST00000338291;ENST00000392807 2 0.78916 1.5377 0.80283 1.0425 0.97438 1.0413 Autophagy_act_C;Autophagy_Cterm;Autophagy_N cell part;cytoplasmic part;cytoplasmic ubiquitin ligase complex;cytosol;intracellular part;macromolecular complex;protein complex;ubiquitin ligase complex acid-amino acid ligase activity;binding;catalytic activity;enzyme binding;ligase activity;ligase activity, forming carbon-nitrogen bonds;protein binding;small conjugating protein ligase activity autophagy;catabolic process;cellular process;macromolecule catabolic process;metabolic process;protein metabolic process;protein modification process;protein transport;protein ubiquitination;proteolysis;transport Regulation of autophagy 9 9 9 31.2 31.2 31.2 35.864 1.4612E-127 302630000 168450000 134180000 1675 IPI:IPI00022254.4;IPI:IPI00449201.2 Autophagy-related protein 3;APG3-like;Protein PC3-96 ATG3;APG3;APG3L Q9NT62-1;Q9NT62;Q9NT62-2 ENST00000283290;ENST00000402314 K08343 2 0.72818 1.4926 0.77239 0.96686 0.98677 1.0032 Adap_comp_sub AP-type membrane coat adaptor complex;clathrin adaptor complex;clathrin coat;clathrin coat of coated pit;cytosol;macromolecular complex;membrane;membrane coat;microbody;microbody membrane;organelle;organelle membrane;peroxisomal membrane binding;lipid binding;protein binding;transporter activity cellular process;intracellular protein transport;protein transport;regulation of defense response;regulation of immune effector process;regulation of immune system process;regulation of response to biotic stimulus;transport;vesicle-mediated transport Huntington's disease 8 8 8 20 20 20 49.654 1.0968E-89 453560000 260320000 193240000 1676 IPI:IPI00022256.3;IPI:IPI00619900.2 AP-2 complex subunit mu-1;Adaptin-mu2;AP-2 mu-2 chain;Plasma membrane adaptor AP-2 50 kDa protein;HA2 50 kDa subunit;Clathrin assembly protein complex 2 medium chain;Clathrin coat assembly protein AP50;Clathrin coat-associated protein AP50 AP2M1;CLAPM1;KIAA0109 Q96CW1-1;Q96CW1;Q96CW1-2 ENST00000292807;ENST00000382456 K11826 2 0.83862 1.594 1.0049 1.0289 1.1223 1.2555 DUF812 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 11 11 11 20.7 20.7 20.7 70.755 1.8126E-77 76569000 39874000 36695000 1678 IPI:IPI00022265.3 Coiled-coil domain-containing protein 22 CCDC22;CXorf37;JM1 O60826 ENST00000376227 1 0.73138 1.7206 0.79399 1.0232 1.0765 1.0359 Syja_N endoplasmic reticulum membrane;Golgi apparatus;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane;membrane-bounded organelle;organelle;organelle membrane;organelle part catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;phosphatase activity;phosphoric ester hydrolase activity 21 21 21 39 39 39 66.966 4.2721E-199 848010000 425180000 422820000 1679 IPI:IPI00022275.6 Phosphatidylinositide phosphatase SAC1;Suppressor of actin mutations 1-like protein SACM1L;KIAA0851 Q9NTJ5 ENST00000389061 1 0.76188 1.4148 0.76785 0.93624 1.0157 1.0021 MRP-S35 cytoplasmic part;intracellular part;macromolecular complex;mitochondrial part;mitochondrial small ribosomal subunit;organellar small ribosomal subunit;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit 5 5 5 31 31 31 20.843 1.0099E-21 199200000 108740000 90456000 1680 IPI:IPI00022276.3 28S ribosomal protein S28, mitochondrial;MRP-S28;MRP-S35 MRPS28;MRPS35;HSPC007 Q9Y2Q9 ENST00000276585 1 NaN 1.559 NaN NaN 1.0829 NaN ig;Pkinase_Tyr cell part;cytoplasm;extracellular region part;extracellular space;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane part;membrane-bounded organelle;nucleus;organelle catalytic activity;nucleoside binding;nucleotide binding;protein kinase activity;protein tyrosine kinase activity;purine nucleoside binding;receptor signaling protein activity;receptor signaling protein tyrosine kinase activity;signal transducer activity cell communication;cell surface receptor linked signal transduction;cellular process;enzyme linked receptor protein signaling pathway;regulation of biological process;signal transduction;transmembrane receptor protein tyrosine kinase signaling pathway Acute myeloid leukemia;Cytokine-cytokine receptor interaction;Hematopoietic cell lineage;Melanogenesis;Pathways in cancer 3 2 2 2.7 1.8 1.8 109.86 1.1535E-06 12008000 6806400 5201700 1682 IPI:IPI00022296.1;IPI:IPI00848233.1 Mast/stem cell growth factor receptor;Proto-oncogene tyrosine-protein kinase Kit KIT P10721-1;P10721;P10721-2 ENST00000288135 K05091 2 0.72338 1.3152 0.68697 0.98583 0.87148 0.89913 W2 binding;protein binding anatomical structure development;cell differentiation;cellular developmental process;cellular process;developmental process;nervous system development;system development 17 15 15 44.4 41.3 41.3 48.162 0 608970000 325930000 283040000 1683 IPI:IPI00022305.4 Basic leucine zipper and W2 domain-containing protein 2 BZW2;HSPC028;MSTP017 Q9Y6E2 ENST00000258761 1 0.65344 1.6968 0.64912 0.9064 1.0704 0.9263 Sod_Fe_C;Sod_Fe_N cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part binding;catalytic activity;cation binding;ion binding;manganese ion binding;metal ion binding;oxidoreductase activity;oxidoreductase activity, acting on superoxide radicals as acceptor;protein binding;superoxide dismutase activity age-dependent response to reactive oxygen species;circulatory system process;release of cytochrome c from mitochondria;response to oxygen radical;response to reactive oxygen species;response to superoxide;system process Huntington's disease 5 5 5 23.4 23.4 23.4 24.722 6.1438E-97 95109000 51561000 43548000 1684 IPI:IPI00022314.1 Superoxide dismutase [Mn], mitochondrial SOD2 P04179 ENST00000337404;ENST00000367055 K04564 1 0.6754 1.2889 0.69438 0.89038 0.87531 0.86237 Ribosomal_S18 cytoplasmic part;intracellular part;macromolecular complex;mitochondrial part;mitochondrial small ribosomal subunit;organellar small ribosomal subunit;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 5 5 5 25.2 25.2 25.2 29.395 1.4565E-52 119500000 62903000 56596000 1685 IPI:IPI00022316.3 28S ribosomal protein S18b, mitochondrial;MRP-S18-b;MRP-S18-2 MRPS18B;HSPC183;PTD017 Q9Y676 ENST00000259873;ENST00000327800;ENST00000383428 1 0.8172 1.385 0.85291 0.99233 0.98954 1.0233 7tm_2;GPS;HRM;TSP_1 cell junction;cell part;cell-cell junction;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part binding;brain-specific angiogenesis inhibitor activity;G-protein coupled receptor activity;molecular transducer activity;protein binding;receptor activity;signal transducer activity;transmembrane receptor activity axonogenesis;cell adhesion;cell communication;cell surface receptor linked signal transduction;G-protein coupled receptor protein signaling pathway;neuropeptide signaling pathway;peripheral nervous system development;signal transduction p53 signaling pathway 3 3 3 1.5 1.5 1.5 173.53 0.0050865 56145000 28362000 27783000 1686 IPI:IPI00022333.1 Brain-specific angiogenesis inhibitor 1 BAI1 O14514 ENST00000323289 K04596 1 0.71209 1.2651 0.7558 0.9666 0.86306 0.96853 Aminotran_3 cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part binding;catalytic activity;lipid binding;ornithine-oxo-acid transaminase activity;protein binding;pyridoxal phosphate binding;steroid binding;transaminase activity;transferase activity;transferase activity, transferring nitrogenous groups;vitamin binding cognition;multicellular organismal process;neurological system process;sensory perception;sensory perception of light stimulus;system process;visual perception Arginine and proline metabolism 21 21 21 53.5 53.5 53.5 48.534 0 1009900000 535430000 474430000 1687 IPI:IPI00022334.1 Ornithine aminotransferase, mitochondrial;Ornithine--oxo-acid aminotransferase;Ornithine aminotransferase, hepatic form;Ornithine aminotransferase, renal form OAT P04181 ENST00000368845;ENST00000405216 K00819 1 0.87812 1.4256 0.65329 1.0399 1.0386 0.78859 cell part;cytoplasmic part;cytosol;external side of plasma membrane;integral to membrane;integral to plasma membrane;intracellular part;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part binding;coreceptor activity;identical protein binding;molecular transducer activity;protein binding;receptor activity;signal transducer activity cell activation;immune system process;leukocyte differentiation;positive regulation of immune system process;regulation of cytokine production;regulation of immune system process;regulation of leukocyte activation Allograft rejection;Autoimmune thyroid disease;Cell adhesion molecules (CAMs);Graft-versus-host disease;Systemic lupus erythematosus;T cell receptor signaling pathway;Type I diabetes mellitus 2 2 2 9.1 9.1 9.1 25.066 0.0063625 48715000 27954000 20761000 1688 IPI:IPI00022339.1;IPI:IPI00215640.1;IPI:IPI00215641.1;IPI:IPI00215639.1 T-cell-specific surface glycoprotein CD28;TP44 CD28 P10747-1;P10747;P10747-3;P10747-4;P10747-2 ENST00000324106;ENST00000374481 K06470 4 0.50603 NaN 0.45163 0.71184 NaN 0.64653 MFS_1 cell part;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part molecular transducer activity;receptor activity;signal transducer activity;transporter activity establishment of localization;transport 2 2 2 5.8 5.8 5.8 59.862 2.2561E-10 3949900 2183800 1766100 1689 IPI:IPI00022344.1 Feline leukemia virus subgroup C receptor-related protein 1 FLVCR1;FLVCR Q9Y5Y0 ENST00000366971 K08220 1 0.85685 1.6719 0.76216 1.1313 1.0944 0.94157 zf-B_box;zf-C3HC4 cell fraction;cytoplasm;insoluble fraction;intracellular non-membrane-bounded organelle;intracellular organelle;membrane;non-membrane-bounded organelle;nuclear body;nuclear membrane;nucleolus;organelle;organelle membrane;organelle part;PML body binding;DNA binding;enzyme binding;identical protein binding;nucleic acid binding;protein binding;protein homodimerization activity;small conjugating protein binding;SUMO binding;SUMO polymer binding;ubiquitin protein ligase binding;zinc ion binding nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein complex assembly;regulation of cell growth;regulation of transcription, DNA-dependent;response to hypoxia;transcription Acute myeloid leukemia;Pathways in cancer;Ubiquitin mediated proteolysis 19 19 2 26 26 2.2 97.55 8.301E-251 550690000 277360000 273330000 1690 IPI:IPI00022348.2;IPI:IPI00922504.1;IPI:IPI00922350.1;IPI:IPI00304000.1;IPI:IPI00303999.1;IPI:IPI00940182.1 Probable transcription factor PML;Tripartite motif-containing protein 19;RING finger protein 71 PML;MYL;RNF71;TRIM19 P29590-1;P29590;P29590-7;P29590-6;P29590-3;P29590-2;P29590-4 ENST00000268058;ENST00000268059;ENST00000395135 K10054 6 0.61205 1.0012 0.55883 0.7518 0.70142 0.7198 NOB1_Zn_bind cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding 4 4 4 10.2 10.2 10.2 47.724 5.1132E-07 210410000 110890000 99519000 1691 IPI:IPI00022373.2 RNA-binding protein NOB1;Protein ART-4;Phosphorylation regulatory protein HP-10 NOB1;ART4;NOB1P;PSMD8BP1;MSTP158 Q9ULX3 ENST00000268802 K11883 1 0.81793 1.7621 0.81928 1.1077 1.1599 1.1042 binding;protein binding 2 2 2 8.8 8.8 8.8 26.534 4.6882E-13 44434000 23542000 20892000 1692 IPI:IPI00022386.2 Thioredoxin domain-containing protein 9;Protein 1-4;ATP-binding protein associated with cell differentiation TXNDC9;APACD O14530 ENST00000264255 1 NaN 1.5381 0.90418 NaN 1.0173 1.2147 DUF1754 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part 2 2 2 19.6 19.6 19.6 13.178 3.6026E-14 40475000 20836000 19639000 1693 IPI:IPI00022402.3 Protein FAM32A FAM32A;CGI-144 Q9Y421 ENST00000263384 1 0.807 1.4287 0.75816 1.0212 0.94003 0.9833 Ribosomal_L13 cytoplasmic part;intracellular part;large ribosomal subunit;macromolecular complex;mitochondrial large ribosomal subunit;mitochondrial part;organellar large ribosomal subunit;organelle part;ribonucleoprotein complex;ribosomal subunit structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation Ribosome 10 10 10 71.3 71.3 71.3 20.692 1.078E-43 288930000 153180000 135740000 1694 IPI:IPI00022403.1 39S ribosomal protein L13, mitochondrial MRPL13 Q9BYD1 ENST00000306185 K02871 1 0.71126 1.7531 0.76772 1.0528 1.1044 1.1141 PP-binding cytoplasmic part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;mitochondrial matrix;mitochondrial part;mitochondrial respiratory chain complex I;NADH dehydrogenase complex;organelle part;protein complex acyl carrier activity;amino acid binding;binding;calcium ion binding;catalytic activity;fatty acid binding;lipid binding;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity;oxidoreductase activity;transporter activity fatty acid biosynthetic process;fatty acid metabolic process;generation of precursor metabolites and energy;lipid metabolic process;metabolic process;mitochondrial electron transport, NADH to ubiquinone;organic acid metabolic process;transport Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 8 8 8 32.7 32.7 32.7 17.417 4.1743E-65 1552300000 828010000 724320000 1695 IPI:IPI00022442.2 Acyl carrier protein, mitochondrial;NADH-ubiquinone oxidoreductase 9.6 kDa subunit;CI-SDAP NDUFAB1 O14561 ENST00000007516 K03955 1 0.64441 2.0506 NaN 0.86182 1.3719 NaN cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part acyltransferase activity;catalytic activity;transferase activity;transferase activity, transferring acyl groups;transferase activity, transferring acyl groups other than amino-acyl groups biosynthetic process;cellular metabolic process;cellular process;lipid biosynthetic process;lipid metabolic process;metabolic process;organophosphate metabolic process;phospholipid biosynthetic process;phospholipid metabolic process 2 2 2 6.8 6.8 6.8 43.089 3.505E-16 13453000 7001300 6451400 1696 IPI:IPI00022447.3 Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 LPGAT1;FAM34A;KIAA0205 Q92604 ENST00000366996;ENST00000366997 1 0.6021 1.2127 0.59627 0.79718 0.79682 0.79052 SH3_2 cell part;cytoplasmic part;cytoskeleton;cytosol;endomembrane system;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane;non-membrane-bounded organelle;organelle binding;electron carrier activity;guanyl-nucleotide exchange factor activity;iron ion binding;protein binding;Ras guanyl-nucleotide exchange factor activity;receptor binding;Rho guanyl-nucleotide exchange factor activity;small GTPase regulator activity actin filament-based process;behavior;cell migration;cell motion;cellular component organization;cellular process;chemotaxis;cytoskeleton organization;immune system process;locomotory behavior;organelle organization;response to external stimulus Chemokine signaling pathway 59 59 59 39.5 39.5 39.5 211.95 0 1792700000 1012400000 780380000 1697 IPI:IPI00022449.6;IPI:IPI00099332.6;IPI:IPI00746684.4 Dedicator of cytokinesis protein 2 DOCK2;KIAA0209 Q92608-1;Q92608 ENST00000256935;ENST00000343291 K12367 3 0.93532 1.5161 0.71039 1.1797 1.0665 0.9623 TBC cell part;intracellular binding;enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;protein binding;Rab GTPase activator activity;Ras GTPase activator activity;small GTPase regulator activity biological regulation;regulation of catalytic activity;regulation of GTPase activity;regulation of hydrolase activity;regulation of molecular function;regulation of Rab GTPase activity;regulation of Ras GTPase activity 5 5 5 6.4 6.4 6.4 89.003 3.2898E-21 15402000 7937100 7465100 1698 IPI:IPI00022450.1 TBC1 domain family member 5 TBC1D5;KIAA0210 Q92609 ENST00000253692 1 0.70873 1.3548 0.67805 0.90851 0.90705 0.86871 PA;TFR_dimer cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;endosome;extracellular region;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;melanosome;membrane-bounded vesicle;organelle;vesicle molecular transducer activity;receptor activity;signal transducer activity;transferrin receptor activity;transmembrane receptor activity cellular cation homeostasis;cellular component organization;cellular homeostasis;cellular ion homeostasis;cellular iron ion homeostasis;cellular process;endocytosis;membrane invagination;membrane organization;transport;vesicle-mediated transport Hematopoietic cell lineage 30 30 30 45.1 45.1 45.1 84.87 0 2906900000 1585500000 1321400000 1700 IPI:IPI00022462.2 Transferrin receptor protein 1;T9;p90;Transferrin receptor protein 1, serum form TFRC P02786 ENST00000360110;ENST00000392396 K06503 1 1.0969 2.0725 NaN 1.4415 1.2955 NaN CARD CBM complex;cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;lysosome;lytic vacuole;macromolecular complex;membrane-bounded organelle;nucleus;organelle;protein complex;vacuole binding;enzyme binding;kinase binding;protein binding;protein C-terminus binding;protein kinase binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding activation of innate immune response;morphogenesis of an epithelium;neural tube closure;pattern recognition receptor signaling pathway;positive regulation of cytokine production;regulation of cytokine production;toll-like receptor signaling pathway B cell receptor signaling pathway;T cell receptor signaling pathway 2 2 2 9.9 9.9 9.9 26.251 3.4617E-07 3875100 2172100 1703000 1701 IPI:IPI00022477.1 B-cell lymphoma/leukemia 10;B-cell CLL/lymphoma 10;CED-3/ICH-1 prodomain homologous E10-like regulator;CARD-containing molecule enhancing NF-kappa-B;Cellular homolog of vCARMEN;Mammalian CARD-containing adapter molecule E10;Cellular-E10;CARD-like apoptotic protein BCL10;CIPER;CLAP O95999 ENST00000271015;ENST00000370580;ENST00000394761 K07368 1 0.42512 1.0271 0.4431 0.59592 0.66751 0.61655 C1_1;HR1;PH;Pkinase;Pkinase_C;Rho_Binding centriole;cytoskeletal part;cytosol;Golgi apparatus part;Golgi membrane;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane;non-membrane-bounded organelle;organelle;organelle membrane;organelle part ATP binding;binding;catalytic activity;kinase activity;lipid binding;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity;zinc ion binding apoptosis;cell adhesion;cell communication;cytokinesis;cytoskeleton organization;leukocyte adhesion;organelle organization;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process Axon guidance;Chemokine signaling pathway;Focal adhesion;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;TGF-beta signaling pathway;Vascular smooth muscle contraction;Wnt signaling pathway 17 17 15 11.4 11.4 9.9 158.17 1.4344E-63 119700000 70469000 49228000 1702 IPI:IPI00022542.1 Rho-associated protein kinase 1;Rho-associated, coiled-coil-containing protein kinase 1;p160 ROCK-1;Renal carcinoma antigen NY-REN-35 ROCK1 Q13464 ENST00000399799 K04514 1 0.89367 1.4209 1.0441 1.1187 0.98498 1.3024 Peptidase_C13 cell part;cytoplasmic part;endoplasmic reticulum part;GPI-anchor transamidase complex;intracellular organelle part;intracellular part;macromolecular complex;membrane part;organelle part;protein complex binding;catalytic activity;cysteine-type endopeptidase activity;cysteine-type peptidase activity;endopeptidase activity;GPI-anchor transamidase activity;hydrolase activity;peptidase activity;protein binding attachment of GPI anchor to protein;catabolic process;cellular process;macromolecule catabolic process;metabolic process;protein folding;protein metabolic process;protein modification process;protein thiol-disulfide exchange;proteolysis Glycosylphosphatidylinositol(GPI)-anchor biosynthesis 2 2 2 5.8 5.8 5.8 45.251 8.2556E-31 7625600 4198100 3427500 1703 IPI:IPI00022543.4 GPI-anchor transamidase;Phosphatidylinositol-glycan biosynthesis class K protein PIGK;GPI8 Q92643 ENST00000370812 K05290 1 0.79974 1.4996 0.87542 1.0857 1.0194 1.0729 UQ_con acid-amino acid ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;ubiquitin-protein ligase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein metabolic process;protein modification process;proteolysis;regulation of metabolic process Ubiquitin mediated proteolysis 7 7 7 31.7 31.7 31.7 20.9 5.5777E-19 523060000 260680000 262380000 1704 IPI:IPI00022597.1 NEDD8-conjugating enzyme Ubc12;Ubiquitin-conjugating enzyme E2 M;NEDD8 protein ligase;NEDD8 carrier protein UBE2M;UBC12 P61081 ENST00000253023 K10579 1 3.4102 8.0785 3.3386 4.306 4.943 4.3924 IRS;PH binding;identical protein binding;insulin receptor binding;protein binding;protein complex binding;receptor binding 7 7 7 22.6 22.6 22.6 45.378 2.5568E-77 157030000 52733000 104300000 1705 IPI:IPI00022602.2 Docking protein 2;Downstream of tyrosine kinase 2;p56(dok-2) DOK2 O60496 ENST00000276420 1 1.2344 2.1302 NaN 1.5492 1.3131 NaN fn3;Ldl_recept_a;Ldl_recept_b extracellular region part;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;low-density lipoprotein particle;macromolecular complex;membrane part;plasma lipoprotein particle;protein-lipid complex binding;lipoprotein binding;low-density lipoprotein binding;molecular transducer activity;protein binding;receptor activity;signal transducer activity;transmembrane receptor activity alcohol metabolic process;biosynthetic process;cellular process;cholesterol metabolic process;endocytosis;lipid metabolic process;lipid transport;membrane invagination;metabolic process;receptor-mediated endocytosis;steroid metabolic process;transport 4 4 4 1.8 1.8 1.8 248.44 2.1128E-09 881550 502320 379240 1706 IPI:IPI00022608.1 Sortilin-related receptor;Sorting protein-related receptor containing LDLR class A repeats;SorLA-1;Low-density lipoprotein receptor relative with 11 ligand-binding repeats SORL1 Q92673 ENST00000260197 1 0.51951 1.1153 0.53768 0.69483 0.69715 0.79087 Nop14 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;nucleic acid binding;protein binding;RNA binding;snoRNA binding cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;ribonucleoprotein complex biogenesis;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 14 14 14 16.2 16.2 16.2 97.667 5.5967E-74 309640000 170280000 139360000 1707 IPI:IPI00022613.4;IPI:IPI00743803.1 Nucleolar protein 14;Nucleolar complex protein 14 NOP14;C4orf9;NOL14;RES4-25 P78316-1;P78316;P78316-2 ENST00000314262;ENST00000398071 2 1.2638 2.6064 1.4336 1.7157 1.6356 1.8718 MAP65_ASE1 cell part;cytoplasm;cytoskeletal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;microtubule;nucleus;organelle;organelle part;spindle microtubule binding;protein binding cell cycle process;cell division;cellular process;cytokinesis;microtubule-based process;mitotic spindle elongation;spindle elongation 4 1 1 9 1.6 1.6 71.606 5.7025E-14 31970000 14988000 16983000 1708 IPI:IPI00022629.6;IPI:IPI00915034.1 Protein regulator of cytokinesis 1 PRC1 O43663-1;O43663;O43663-3 ENST00000361919;ENST00000394249 2 0.73661 1.3779 0.84636 1.0406 0.91246 1.0813 eIF-5_eIF-2B;W2 cell part;cytoplasmic part;cytosol;intracellular part binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;nucleic acid binding;nucleotide binding;pyrophosphatase activity;translation factor activity, nucleic acid binding;translation initiation factor activity cellular process;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of translation;regulation of translational initiation;translational initiation 14 14 14 34.8 34.8 34.8 49.222 0 737780000 369470000 368310000 1709 IPI:IPI00022648.2 Eukaryotic translation initiation factor 5 EIF5 P55010 ENST00000216554;ENST00000392715 K03262 1 0.70948 1.3422 0.65356 0.89418 0.94064 0.80551 AA_permease;AA_permease_N cell fraction;cell part;insoluble fraction;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane fraction;membrane part;plasma membrane part anion transmembrane transporter activity;binding;cation transmembrane transporter activity;ion transmembrane transporter activity;secondary active transmembrane transporter activity;sodium:potassium:chloride symporter activity;transporter activity ammonium transport;anion transport;cation transport;chloride transport;inorganic anion transport;ion transport;metal ion transport;monovalent inorganic cation transport;organic cation transport;potassium ion transport;sodium ion transport;transport Vibrio cholerae infection 7 7 7 8.1 8.1 8.1 131.45 4.0139E-65 44419000 23302000 21116000 1710 IPI:IPI00022649.3;IPI:IPI00220844.1 Solute carrier family 12 member 2;Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1;Basolateral Na-K-Cl symporter SLC12A2;NKCC1 P55011-1;P55011;P55011-3 ENST00000262461;ENST00000343225 K10951 2 0.48715 1.1333 0.47046 0.6321 0.76353 0.63287 LRR_1;PPTA;RabGGT_insert binding;catalytic activity;prenyltransferase activity;protein binding;protein geranylgeranyltransferase activity;protein prenyltransferase activity;Rab geranylgeranyltransferase activity;transferase activity;zinc ion binding cellular process;metabolic process;multicellular organismal process;protein amino acid lipidation;protein amino acid prenylation;protein metabolic process;protein modification process;protein prenylation;sensory perception;system process;visual perception 17 17 17 33.7 33.7 33.7 65.071 1.3293E-194 276890000 158140000 118750000 1711 IPI:IPI00022664.3 Geranylgeranyl transferase type-2 subunit alpha;Geranylgeranyl transferase type II subunit alpha;Rab geranylgeranyltransferase subunit alpha;Rab geranyl-geranyltransferase subunit alpha RABGGTA Q92696 ENST00000216840;ENST00000399409 K05956 1 0.94597 1.616 0.99355 1.2246 1.0693 1.226 UIM cell part;cytoplasmic part;cytosol;intracellular part;macromolecular complex;proteasome complex;protein complex binding;protein binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Proteasome 9 9 7 26.1 26.1 18.7 41.079 2.9741E-144 941150000 475260000 465890000 1712 IPI:IPI00216247.2;IPI:IPI00022694.3 26S proteasome non-ATPase regulatory subunit 4;26S proteasome regulatory subunit S5A;Rpn10;Multiubiquitin chain-binding protein;Antisecretory factor 1 PSMD4;MCB1 P55036-2;P55036;P55036-1 ENST00000368881;ENST00000368884 K03029 2 0.75095 1.699 0.74527 1.0207 1.0908 1.0169 MMR_HSR1;TGS cell part;cytoplasm;intracellular part binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding biological regulation;cell communication;cellular process;regulation of biological process;regulation of cellular process;signal transduction 15 15 15 46.7 46.7 46.7 40.746 1.056E-203 220260000 118920000 101340000 1713 IPI:IPI00022697.3 Developmentally-regulated GTP-binding protein 2 DRG2 P55039 ENST00000225729 1 0.67829 1.4914 0.71464 0.90346 0.97337 0.94867 CAS_CSE1;Cse1;IBN_N cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;organelle part;pore complex;protein complex binding;importin-alpha export receptor activity;nuclear export signal receptor activity;protein binding;protein transporter activity;substrate-specific transporter activity;transporter activity anatomical structure formation;apoptosis;cell death;cell proliferation;cellular component assembly;cellular component organization;cellular process;death;programmed cell death;protein complex assembly;protein import into nucleus, docking 34 34 34 40 40 40 110.42 0 35841000000 19201000000 16640000000 1714 IPI:IPI00022744.5;IPI:IPI00219994.2;IPI:IPI00219762.3 Exportin-2;Importin-alpha re-exporter;Chromosome segregation 1-like protein;Cellular apoptosis susceptibility protein CSE1L;CAS;XPO2 P55060-1;P55060;P55060-3 ENST00000262982;ENST00000396192 3 0.55742 1.0239 0.58297 0.70643 0.64496 0.7101 GHMP_kinases_C;GHMP_kinases_N cell part;cytoplasmic part;cytosol;intracellular part ATP binding;binding;catalytic activity;diphosphomevalonate decarboxylase activity;kinase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups alcohol metabolic process;cholesterol biosynthetic process;isoprenoid metabolic process;lipid metabolic process;metabolic process;phosphate metabolic process;phosphorus metabolic process;steroid biosynthetic process;steroid metabolic process Biosynthesis of steroids 5 5 5 17.8 17.8 17.8 43.404 2.1703E-52 93900000 50173000 43727000 1715 IPI:IPI00022745.1 Diphosphomevalonate decarboxylase;Mevalonate pyrophosphate decarboxylase;Mevalonate (diphospho)decarboxylase MVD;MPD P53602 ENST00000301012 K01597 1 NaN 0.6876 0.49109 NaN 0.49077 0.62048 BACK;BTB;Kelch_1 cell part;cytoplasm;cytoskeletal part;intermediate filament;intracellular organelle part;intracellular part;neurofilament;organelle part binding;protein binding catabolic process;cell death;cellular biopolymer metabolic process;cellular process;death;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 5 5 5 9 9 9 67.638 4.9315E-31 25882000 13757000 12125000 1716 IPI:IPI00022758.3 Gigaxonin;Kelch-like protein 16 GAN;GAN1;KLHL16 Q9H2C0 ENST00000248272 K10453 1 0.87053 1.5983 0.914 1.1543 1.0434 1.1212 Prenyltrans CAAX-protein geranylgeranyltransferase complex;cell part;intracellular part;macromolecular complex;protein complex binding;CAAX-protein geranylgeranyltransferase activity;catalytic activity;prenyltransferase activity;protein geranylgeranyltransferase activity;protein prenyltransferase activity;transferase activity;zinc ion binding cellular process;metabolic process;protein amino acid geranylgeranylation;protein amino acid lipidation;protein amino acid prenylation;protein geranylgeranylation;protein metabolic process;protein modification process;protein prenylation 9 9 9 22.3 22.3 22.3 42.368 5.6411E-19 130350000 69471000 60882000 1717 IPI:IPI00022759.3;IPI:IPI00549741.3 Geranylgeranyl transferase type-1 subunit beta;Geranylgeranyl transferase type I subunit beta;Type I protein geranyl-geranyltransferase subunit beta PGGT1B P53609-1;P53609;P53609-2 ENST00000296642;ENST00000379615 2 0.91147 1.7235 0.8956 1.1912 1.1338 1.1662 AAA;CDC48_2;CDC48_N cell fraction;cytoplasmic part;cytosol;endoplasmic reticulum;insoluble fraction;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane fraction;membrane-bounded organelle;microsome;nucleus;organelle;vesicular fraction ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;lipid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity DNA metabolic process;DNA repair;double-strand break repair;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein modification process;proteolysis;ubiquitin-dependent protein catabolic process 49 49 49 66.9 66.9 66.9 89.321 0 6222300000 3233700000 2988600000 1718 IPI:IPI00022774.3 Transitional endoplasmic reticulum ATPase;15S Mg(2+)-ATPase p97 subunit;Valosin-containing protein VCP P55072 ENST00000358901 1 0.79006 1.6495 0.78653 1.0612 1.0679 1.1413 MFAP1_C extracellular matrix part;extracellular region part;extracellular space;fibril;microfibril 4 4 4 13.2 13.2 13.2 51.958 4.3184E-12 88895000 44644000 44251000 1719 IPI:IPI00022790.2 Microfibrillar-associated protein 1 MFAP1 P55081 ENST00000267812 1 0.8495 1.6256 0.82466 1.0665 1.0715 1.0482 Thiolase_C;Thiolase_N cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial nucleoid;mitochondrial part;nucleoid;organelle part 3-hydroxyacyl-CoA dehydrogenase activity;acetyl-CoA C-acyltransferase activity;acyltransferase activity;C-acyltransferase activity;catalytic activity;enoyl-CoA hydratase activity;oxidoreductase activity catabolic process;cellular process;fatty acid beta-oxidation;fatty acid catabolic process;fatty acid metabolic process;lipid catabolic process;lipid metabolic process;metabolic process;organic acid catabolic process;organic acid metabolic process Benzoate degradation via hydroxylation;Fatty acid elongation in mitochondria;Fatty acid metabolism;Valine, leucine and isoleucine degradation 19 19 19 44.9 44.9 44.9 51.294 1.8883E-241 1381500000 724420000 657120000 1720 IPI:IPI00022793.5 Trifunctional enzyme subunit beta, mitochondrial;TP-beta;3-ketoacyl-CoA thiolase;Acetyl-CoA acyltransferase;Beta-ketothiolase HADHB;MSTP029 P55084 ENST00000317799 K07509 1 0.74238 1.2441 0.6987 0.96314 0.82782 0.93123 CathepsinC_exc;Peptidase_C1 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;lysosome;lytic vacuole;membrane-bounded organelle;organelle;vacuole anion binding;binding;catalytic activity;chloride ion binding;cysteine-type endopeptidase activity;cysteine-type peptidase activity;endopeptidase activity;hydrolase activity;ion binding;peptidase activity biopolymer metabolic process;catabolic process;immune response;immune system process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;protein catabolic process;protein metabolic process;proteolysis 9 9 9 23.5 23.5 23.5 51.841 1.6463E-97 569700000 302230000 267480000 1721 IPI:IPI00022810.1 Dipeptidyl-peptidase 1;Dipeptidyl-peptidase I;Cathepsin C;Cathepsin J;Dipeptidyl transferase;Dipeptidyl-peptidase 1 exclusion domain chain;Dipeptidyl-peptidase I exclusion domain chain;Dipeptidyl-peptidase 1 heavy chain;Dipeptidyl-peptidase I heavy chain;Dipeptidyl-peptidase 1 light chain;Dipeptidyl-peptidase I light chain CTSC;CPPI P53634 ENST00000227266 1 0.92987 1.4618 0.95484 1.1771 1.0055 1.2336 TFIIB;TFIIB_Zn_Ribbon cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex binding;general RNA polymerase II transcription factor activity;nucleic acid binding;protein binding;RNA polymerase II transcription factor activity;translation factor activity, nucleic acid binding;translation initiation factor activity;zinc ion binding nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;RNA elongation;transcription initiation;transcription initiation from RNA polymerase II promoter Basal transcription factors 6 6 6 24.7 24.7 24.7 34.833 3.6082E-111 171670000 84325000 87342000 1722 IPI:IPI00022820.1 Transcription initiation factor IIB;General transcription factor TFIIB;S300-II GTF2B;TF2B;TFIIB Q00403 ENST00000370500 K03124 1 0.77455 1.7109 0.78441 1.122 1.0517 1.1319 Pkinase cell part;cytoplasm;intracellular part ATP binding;binding;catalytic activity;DNA binding;kinase activity;nuclease activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity DNA metabolic process;DNA repair;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleotide-excision repair;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process 13 13 12 11.6 11.6 11.6 142.69 1.8468E-133 123720000 65171000 58553000 1724 IPI:IPI00022827.1;IPI:IPI00247439.3;IPI:REV_IPI00328306.9 STE20-like serine/threonine-protein kinase;STE20-related serine/threonine-protein kinase;Serine/threonine-protein kinase 2;CTCL tumor antigen se20-9 SLK;KIAA0204;STK2 Q9H2G2-1;Q9H2G2;Q9H2G2-2 ENST00000335753;ENST00000369755 K08836 3 0.52128 1.0602 NaN 0.70155 0.68293 NaN TBP cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex;transcription factor TFIIA complex;transcription factor TFIID complex binding;DNA binding;general RNA polymerase II transcription factor activity;nucleic acid binding;protein binding;RNA polymerase II transcription factor activity;transcription factor binding;transcription regulator activity nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;RNA elongation;transcription;transcription from RNA polymerase II promoter;transcription initiation;transcription, DNA-dependent Basal transcription factors;Huntington's disease 3 3 3 10.6 10.6 10.6 37.698 1.4937E-33 12090000 6753300 5336600 1725 IPI:IPI00022831.1;IPI:IPI00791135.1 TATA-box-binding protein;TATA-box factor;TATA-binding factor;TATA sequence-binding protein;Transcription initiation factor TFIID TBP subunit TBP;GTF2D1;TF2D;TFIID P20226 ENST00000230354;ENST00000392092 K03120 2 0.74775 1.6663 0.78506 1.0077 1.0058 1.0328 UPF0041 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle 4 4 4 30.7 30.7 30.7 14.279 3.3496E-121 136690000 75186000 61499000 1726 IPI:IPI00022832.1 Brain protein 44 BRP44 O95563 ENST00000271373;ENST00000367846 1 NaN NaN 0.95209 NaN NaN 1.3419 Clathrin;Clathrin_propel;Clathrin-link clathrin coat;clathrin coat of coated pit;clathrin coat of trans-Golgi network vesicle;clathrin vesicle coat;Golgi apparatus part;intracellular part;macromolecular complex;membrane coat;membrane part;organelle part;protein complex;vesicle coat binding;molecular transducer activity;protein binding;signal transducer activity;structural molecule activity anatomical structure morphogenesis;cellular component organization;cellular process;endocytosis;intracellular protein transport;membrane invagination;membrane organization;protein transport;receptor-mediated endocytosis;transport Huntington's disease 22 1 1 12.4 1 1 187.03 0 4242200 2139100 2103200 1728 IPI:IPI00022881.1;IPI:IPI00300446.1 Clathrin heavy chain 2;CLH-22 CLTCL1;CLH22;CLTCL;CLTD P53675-1;P53675;P53675-2 ENST00000263200;ENST00000353891 K04646 2 0.88173 1.8697 0.91915 1.1326 1.2409 1.185 DUF1692 endoplasmic reticulum membrane;endoplasmic reticulum part;ER-Golgi intermediate compartment membrane;Golgi apparatus part;Golgi membrane;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part binding;protein binding cellular process;ER to Golgi vesicle-mediated transport;establishment of localization;establishment of localization in cell;Golgi vesicle transport;intracellular transport;transport;vesicle-mediated transport 6 6 6 17.9 17.9 17.9 32.592 9.7476E-44 160330000 87404000 72924000 1729 IPI:IPI00022887.4;IPI:IPI00953445.1;IPI:IPI00021763.1 Endoplasmic reticulum-Golgi intermediate compartment protein 1;ER-Golgi intermediate compartment 32 kDa protein ERGIC1;ERGIC32;KIAA1181;HT034 Q969X5-1;Q969X5;Q969X5-2 ENST00000265089;ENST00000326654;ENST00000393784 3 0.86732 1.8223 0.92849 1.1308 1.1755 1.1544 Mito_carr integral to membrane;integral to plasma membrane;intracellular part;intrinsic to membrane;intrinsic to plasma membrane;membrane;membrane part;mitochondrial inner membrane;mitochondrial membrane;organelle inner membrane;organelle membrane;organelle part adenine transmembrane transporter activity;binding;nucleobase transmembrane transporter activity;protein binding;purine transmembrane transporter activity;transporter activity cellular component organization;cellular metabolic process;cellular process;generation of precursor metabolites and energy;metabolic process;mitochondrial genome maintenance;mitochondrion organization;organelle organization Calcium signaling pathway;Huntington's disease;Parkinson's disease 20 5 5 51.7 17.1 17.1 33.064 0 245550000 131640000 113910000 1730 IPI:IPI00022891.3 ADP/ATP translocase 1;Adenine nucleotide translocator 1;ADP,ATP carrier protein 1;Solute carrier family 25 member 4;ADP,ATP carrier protein, heart/skeletal muscle isoform T1 SLC25A4;ANT1 P12235 ENST00000281456 K05863 1 0.89221 1.538 0.73815 1.1636 1.071 0.90062 ig cell projection;endoplasmic reticulum;growth cone;integral to membrane;integral to plasma membrane;intracellular organelle;intrinsic to membrane;intrinsic to plasma membrane;membrane-bounded organelle;neuron projection;organelle;site of polarized growth binding;enzyme activator activity;GTPase activator activity;integrin binding;lipid binding;phospholipid binding;protein binding;Ras GTPase activator activity;receptor binding;Rho GTPase activator activity;small GTPase regulator activity activation of immune response;angiogenesis;immune response-activating cell surface receptor signaling pathway;immune system process;negative regulation of immune system process;regulation of immune system process Leukocyte transendothelial migration 3 3 3 24.2 24.2 24.2 17.935 1.2898E-74 52801000 22894000 29907000 1731 IPI:IPI00022892.2 Thy-1 membrane glycoprotein;Thy-1 antigen;CDw90 THY1 P04216 ENST00000284240 K06514 1 0.82901 1.4688 0.85287 1.0625 0.97803 1.0574 ITAM cell part;cytoplasm;integral to membrane;intracellular part;intrinsic to membrane;macromolecular complex;membrane part;plasma membrane part;protein complex;receptor complex;T cell receptor complex binding;molecular transducer activity;protein binding;protein dimerization activity;protein heterodimerization activity;receptor activity;signal transducer activity;transmembrane receptor activity cell communication;cell surface receptor linked signal transduction;cellular process;immune system process;positive T cell selection;positive thymic T cell selection;signal transduction;T cell selection;thymic T cell selection Hematopoietic cell lineage;Primary immunodeficiency;T cell receptor signaling pathway 8 8 7 30.4 30.4 26.9 18.929 3.9475E-49 714570000 364400000 350160000 1732 IPI:IPI00022934.1;IPI:REV_IPI00183487.1;IPI:REV_IPI00887371.1 T-cell surface glycoprotein CD3 delta chain;T-cell receptor T3 delta chain CD3D;T3D P04234 ENST00000300692 K06450 3 0.74776 1.4147 0.71136 1.0308 0.89078 0.9498 SYF2 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;protein binding cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 3 3 3 21.4 21.4 21.4 28.722 1.0932E-72 44740000 24203000 20537000 1733 IPI:IPI00022963.3 Pre-mRNA-splicing factor SYF2;CCNDBP1-interactor;p29 SYF2;CBPIN;GCIPIP O95926 ENST00000236273 1 0.28831 39.724 0.23542 0.38618 25.32 0.30004 SVA extracellular region actin binding;binding;cytoskeletal protein binding;protein binding + 9 9 8 52.7 52.7 52.7 16.572 1.8366E-73 79468000 68927000 10541000 1734 IPI:IPI00022974.1 Prolactin-inducible protein;Prolactin-induced protein;Secretory actin-binding protein;Gross cystic disease fluid protein 15;gp17 PIP;GCDFP15;GPIP4 P12273 ENST00000291009 1 NaN 1.6453 0.84927 NaN 1.1563 0.98924 MAPEG endoplasmic reticulum;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane;membrane-bounded organelle;nuclear membrane;organelle;organelle membrane;organelle part binding;carboxylic acid binding;enzyme activator activity;enzyme regulator activity;fatty acid binding;icosanoid binding;icosatetraenoic acid binding;lipid binding;monocarboxylic acid binding;protein binding;protein N-terminus binding fatty acid biosynthetic process;fatty acid metabolic process;icosanoid metabolic process;leukotriene metabolic process;lipid metabolic process;organic acid metabolic process;protein complex assembly;unsaturated fatty acid biosynthetic process 2 2 2 10.6 10.6 10.6 18.157 0.0010168 203860000 167850000 36011000 1735 IPI:IPI00022975.1 Arachidonate 5-lipoxygenase-activating protein;FLAP;MK-886-binding protein ALOX5AP;FLAP P20292 ENST00000380490 1 0.70571 1.398 0.81773 0.94107 0.9265 1.0768 DUF1075 cell part;integral to membrane;intrinsic to membrane;membrane part 6 6 6 35.1 35.1 35.1 17.342 4.2533E-96 359820000 193300000 166520000 1736 IPI:IPI00023001.2 UPF0389 protein FAM162A;E2-induced gene 5 protein FAM162A;C3orf28;E2IG5;DC16;FWP001 Q96A26 ENST00000232125 1 NaN 35.451 NaN NaN 22.36 NaN Semenogelin cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;extracellular region part;extracellular space;intracellular membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;membrane-bounded vesicle;organelle;secretory granule;vesicle structural molecule activity insemination;multicellular organismal process;reproduction;reproductive process;reproductive process in a multicellular organism;sexual reproduction 5 5 3 15.8 15.8 8.4 52.13 4.9301E-60 3603300 3603300 0 1737 IPI:IPI00023020.1;IPI:IPI00414684.7 Semenogelin-1;Semenogelin I;Alpha-inhibin-92;Alpha-inhibin-31;Seminal basic protein SEMG1;SEMG P04279-1;P04279;P04279-2 ENST00000244069;ENST00000372781;ENST00000405932 2 0.63402 1.4459 NaN 0.85025 0.93229 NaN Aa_trans cell part;integral to membrane;intrinsic to membrane;membrane;membrane part;plasma membrane amine transmembrane transporter activity;binding;cation:amino acid symporter activity;organic acid transmembrane transporter activity;organic acid:sodium symporter activity;sodium:amino acid symporter activity;transporter activity cation transport;establishment of localization;ion transport;metal ion transport;monovalent inorganic cation transport;sodium ion transport;transport 2 2 2 3.9 3.9 3.9 54.047 0.00011811 16918000 9236100 7681900 1738 IPI:IPI00023030.4 Sodium-coupled neutral amino acid transporter 1;Amino acid transporter A1;System A amino acid transporter 1;System N amino acid transporter 1;N-system amino acid transporter 2;Solute carrier family 38 member 1 SLC38A1;ATA1;NAT2;SAT1;SNAT1 Q9H2H9 ENST00000354341;ENST00000398637 1 0.72822 1.4399 0.7084 0.9257 0.95845 0.92476 EF-1_beta_acid;EF1_GNE cell part;cytoplasmic part;cytosol;eukaryotic translation elongation factor 1 complex;intracellular part;macromolecular complex;protein complex binding;molecular transducer activity;nucleic acid binding;protein binding;signal transducer activity;translation elongation factor activity;translation factor activity, nucleic acid binding;translation regulator activity biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;positive regulation of signal transduction;regulation of protein kinase cascade;regulation of signal transduction;translational elongation 14 14 1 51.2 51.2 3.2 31.121 0 8068900000 4319500000 3749400000 1739 IPI:IPI00023048.4 Elongation factor 1-delta;Antigen NY-CO-4 EEF1D;EF1D P29692-1;P29692 ENST00000337369;ENST00000356793;ENST00000395119 1 0.80517 1.6027 0.64423 1.1128 1.0437 0.86597 UPF0240 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle binding;calmodulin binding;protein binding 4 4 4 25.1 25.1 25.1 20.266 8.0897E-16 82668000 43605000 39063000 1740 IPI:IPI00023064.1 Protein HRPAP20;Hormone-regulated proliferation-associated protein of 20 kDa HRPAP20;C6orf66;HSPC125;My013 Q9P032 ENST00000316149 1 0.22734 NaN 0.70448 0.29882 NaN 0.90952 Rad51 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;DNA binding;DNA-dependent ATPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity cellular process;DNA metabolic process;DNA recombination;DNA repair;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to DNA damage stimulus;response to stress Homologous recombination 3 3 3 11.3 11.3 11.3 37.849 6.3921E-17 6479600 3383900 3095600 1741 IPI:IPI00023073.1 DNA repair protein XRCC3;X-ray repair cross-complementing protein 3 XRCC3 O43542 ENST00000352127 K10880 1 0.13188 NaN NaN 0.17621 NaN NaN anatomical structure development;developmental process;epidermis development;tissue development 3 3 3 11.6 11.6 11.6 26.238 5.1021E-05 3400000 3157500 242460 1742 IPI:IPI00023078.2 Skin-specific protein 32 XP32;C1orf68 Q5T750 ENST00000362017;ENST00000368775 1 0.70315 1.3878 0.65412 0.93866 0.98516 0.88298 Ribosomal_L15 intracellular membrane-bounded organelle;intracellular organelle;intracellular part;large ribosomal subunit;macromolecular complex;membrane-bounded organelle;mitochondrion;organelle;organelle part;ribonucleoprotein complex;ribosomal subunit structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 11 11 10 37.2 37.2 35.1 33.419 3.5661E-133 264840000 144710000 120130000 1743 IPI:IPI00023086.3 39S ribosomal protein L15, mitochondrial MRPL15;HSPC145 Q9P015 ENST00000260102 1 0.32385 0.76678 0.41389 0.3992 0.52985 0.55803 UQ_con cell part;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part acid-amino acid ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleoside binding;nucleotide binding;purine nucleoside binding;ubiquitin-protein ligase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein metabolic process;protein modification process;proteolysis;regulation of metabolic process 4 4 4 26.4 26.4 26.4 22.521 7.4353E-21 40176000 23866000 16310000 1744 IPI:IPI00023087.1 Ubiquitin-conjugating enzyme E2 T;Ubiquitin-protein ligase T;Ubiquitin carrier protein T UBE2T;HSPC150 Q9NPD8 ENST00000367274 1 0.91511 1.5393 0.90262 1.1363 1.0651 1.1351 Mlf1IP adherens junction;cell junction;cell-substrate adherens junction;cell-substrate junction;cytoplasm;focal adhesion;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding defense response;response to stimulus;response to stress 2 2 2 11.3 11.3 11.3 28.147 5.0588E-09 43189000 22255000 20935000 1745 IPI:IPI00023095.1 Myeloid leukemia factor 2;Myelodysplasia-myeloid leukemia factor 2 MLF2 Q15773 ENST00000203630 1 0.72317 1.3263 0.72879 0.98558 0.85381 1.0303 BAH;Bromodomain;HMG_box cell part;chromosome;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear chromosome;nuclear part;organelle;organelle part binding;chromatin binding;DNA binding;nucleic acid binding;protein binding chromatin organization;chromatin remodeling;mitosis;nitrogen compound metabolic process;nuclear division;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;regulation of transcription, DNA-dependent;transcription 27 27 27 18.4 18.4 18.4 192.95 2.2973E-237 377770000 189320000 188450000 1746 IPI:IPI00384176.1;IPI:IPI00910435.1;IPI:IPI00301041.4;IPI:IPI00909142.1;IPI:IPI00334894.1;IPI:IPI00873041.1;IPI:IPI00023097.1;IPI:IPI00640304.1;IPI:IPI00398781.3 Protein polybromo-1;Polybromo-1D;BRG1-associated factor 180 PBRM1;PB1 Q86U86-1;Q86U86;Q86U86-8;Q86U86-2;Q86U86-9;Q86U86-3;Q86U86-7;Q86U86-5;Q86U86-4;Q86U86-6 ENST00000296302;ENST00000337303;ENST00000356770;ENST00000394830 K11757 9 0.68618 1.5794 0.80666 0.89515 1.0945 1.0538 Rcd1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;reproductive developmental process;sex differentiation;transcription 10 10 10 36.5 36.5 36.5 33.631 3.5542E-216 320770000 171200000 149570000 1747 IPI:IPI00023101.1 Cell differentiation protein RCD1 homolog RQCD1;RCD1 Q92600 ENST00000273064 1 0.49959 0.95362 NaN 0.66833 0.5881 NaN DEP;Dishevelled;DIX;PDZ cell part;cytoplasm;intracellular part anion binding;binding;identical protein binding;ion binding;molecular transducer activity;phosphate binding;protein binding;signal transducer activity cell communication;cell surface receptor linked signal transduction;intracellular signaling cascade;morphogenesis of an epithelium;neural tube closure;pattern specification process;regionalization;segment specification;signal transduction Basal cell carcinoma;Colorectal cancer;Melanogenesis;Notch signaling pathway;Pathways in cancer;Wnt signaling pathway 3 3 3 5.7 5.7 5.7 78.947 1.5956E-05 11274000 7080700 4193000 1748 IPI:IPI00023103.1 Segment polarity protein dishevelled homolog DVL-2;DSH homolog 2 DVL2 O14641 ENST00000005340 K02353 1 NaN 1.4784 NaN NaN 0.97991 NaN LIM;PDZ cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding cell differentiation;cellular component organization;cellular process;developmental process;endocytosis;membrane invagination;membrane organization;ossification;receptor-mediated endocytosis;transport;vesicle-mediated transport 2 2 2 7 7 7 49.844 0.00028854 2376500 1340600 1035900 1749 IPI:IPI00023122.1;IPI:IPI00478185.1;IPI:IPI00060308.3;IPI:IPI00655883.1;IPI:IPI00023560.1;IPI:IPI00030835.1 PDZ and LIM domain protein 7;LIM mineralization protein;Protein enigma PDLIM7;ENIGMA Q9NR12-1;Q9NR12;Q9NR12-4;Q9NR12-6;Q9NR12-5;Q9NR12-2;Q9NR12-3 ENST00000355572;ENST00000355841;ENST00000356618;ENST00000359895;ENST00000393546 6 0.41823 0.90206 0.47277 0.56031 0.61697 0.59254 BING4CT;WD40 8 8 8 18.5 18.5 18.5 68.04 1.6482E-25 159040000 88631000 70408000 1750 IPI:IPI00023126.1 WD repeat-containing protein 46;WD repeat-containing protein BING4 WDR46;BING4;C6orf11;FP221 O15213 ENST00000383074 1 0.92573 1.9146 1.0454 1.1619 1.2604 1.2927 V-SNARE cell part;cytoplasmic part;Golgi apparatus part;Golgi membrane;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part transporter activity cellular component organization;cellular process;ER to Golgi vesicle-mediated transport;establishment of protein localization;intracellular protein transport;membrane fusion;membrane organization;protein transport;transport;vesicle-mediated transport SNARE interactions in vesicular transport 4 4 4 24.9 24.9 24.9 24.583 4.1993E-25 164830000 79392000 85440000 1751 IPI:IPI00216965.1;IPI:IPI00023135.4 Golgi SNAP receptor complex member 2;27 kDa Golgi SNARE protein;Membrin GOSR2;GS27 O14653-2;O14653;O14653-1 ENST00000225567;ENST00000393456 K08496 2 NaN NaN 0.72723 NaN NaN 0.95584 Torsin endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;membrane-enclosed lumen;organelle;organelle lumen;organelle part ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity cellular biopolymer metabolic process;cellular process;'de novo' protein folding;metabolic process;protein folding;protein metabolic process;response to biotic stimulus;response to organic substance;response to stress;response to unfolded protein 6 6 6 22 22 22 37.978 2.1034E-77 13716000 7371900 6344400 1752 IPI:IPI00023137.1 Torsin-1B;Torsin family 1 member B TOR1B;DQ1;FKSG18 O14657 ENST00000259339 1 0.61049 1.419 0.62945 0.90487 0.87449 0.7908 Ras cell projection;cell soma;cytoplasm;cytoskeletal part;endomembrane system;filamentous actin;growth cone;intracellular part;lamellipodium;macromolecular complex;membrane;neuron projection;organelle part;protein complex;site of polarized growth binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity anatomical structure formation;cell communication;cellular component organization;cellular process;cytoskeleton organization;intracellular signaling cascade;organelle organization;signal transduction;small GTPase mediated signal transduction Adherens junction;Axon guidance;B cell receptor signaling pathway;Colorectal cancer;Fc epsilon RI signaling pathway;Focal adhesion;MAPK signaling pathway;Natural killer cell mediated cytotoxicity;Pancreatic cancer;Pathways in cancer;Regulation of actin cytoskeleton;VEGF signaling pathway;Wnt signaling pathway 10 2 2 47.9 13.5 13.5 21.379 4.9455E-96 29801000 16975000 12827000 1753 IPI:IPI00023138.1 Ras-related C3 botulinum toxin substrate 3;p21-Rac3 RAC3 P60763 ENST00000306897 K07861 1 0.86387 1.3437 0.88364 1.0929 0.93494 1.0773 SNARE;Syntaxin cell fraction;Golgi membrane;insoluble fraction;integral to membrane;intracellular part;intrinsic to membrane;macromolecular complex;membrane;membrane fraction;microsome;organelle membrane;organelle part;protein complex;SNARE complex;vesicular fraction binding;protein binding;SNAP receptor activity cellular process;endosome transport;establishment of protein localization;intracellular protein transport;intra-Golgi vesicle-mediated transport;protein transport;retrograde transport, endosome to Golgi;transport;vesicle-mediated transport SNARE interactions in vesicular transport 2 2 2 7.1 7.1 7.1 37.031 8.3344E-35 16160000 8563300 7596700 1754 IPI:IPI00023149.3;IPI:IPI00220263.3;IPI:IPI00220261.5;IPI:IPI00414290.1 Syntaxin-16 STX16 O14662-1;O14662;O14662-4;O14662-2;O14662-3 ENST00000355957;ENST00000361830;ENST00000371138 K08489 4 0.78829 1.7478 0.8074 1.0836 1.1407 1.0312 intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;mitochondrion;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome 5 5 5 19 19 19 31.705 9.2625E-76 153700000 80361000 73335000 1755 IPI:IPI00023161.1 39S ribosomal protein L46, mitochondrial;P2ECSL MRPL46;C15orf4;LIECG2 Q9H2W6 ENST00000312475 1 0.72414 1.178 0.70236 0.9113 0.82298 0.91532 Epimerase_2;ROK cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle ATP binding;binding;catalytic activity;kinase activity;N-acylmannosamine kinase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;transferase activity;UDP-N-acetylglucosamine 2-epimerase activity amino sugar metabolic process;carbohydrate metabolic process;glucosamine metabolic process;monosaccharide metabolic process;N-acetylglucosamine metabolic process;polysaccharide biosynthetic process;polysaccharide metabolic process 15 15 15 27.4 27.4 27.4 79.274 1.5774E-120 170010000 87902000 82105000 1756 IPI:IPI00023162.3 Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase;UDP-GlcNAc-2-epimerase/ManAc kinase;UDP-N-acetylglucosamine 2-epimerase;Uridine diphosphate-N-acetylglucosamine-2-epimerase;UDP-GlcNAc-2-epimerase;N-acetylmannosamine kinase;ManAc kinase GNE;GLCNE Q9Y223 ENST00000339267;ENST00000377902;ENST00000396594 1 0.52413 0.92281 0.06566 0.71823 0.57119 0.087194 cell part;chromatin assembly complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex binding;chromatin binding;protein binding;unfolded protein binding chromatin assembly or disassembly;chromatin organization;DNA metabolic process;DNA repair;DNA replication;DNA replication-dependent nucleosome assembly;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleosome assembly;transcription 6 6 6 7.8 7.8 7.8 106.92 6.4676E-28 47036000 24834000 22202000 1757 IPI:IPI00023177.4;IPI:IPI00219364.2;IPI:IPI00219363.2 Chromatin assembly factor 1 subunit A;Chromatin assembly factor I p150 subunit CHAF1A;CAF;CAF1P150 Q13111-1;Q13111;Q13111-3 ENST00000301280;ENST00000344143;ENST00000394774 K10750 3 0.73143 1.335 0.7425 0.97335 0.91559 0.99957 ThiF;UBA_e1_thiolCys;UBACT cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;enzyme activator activity;enzyme regulator activity;ligase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;purine nucleotide binding;small protein activating enzyme activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;protein modification process;proteolysis Ubiquitin mediated proteolysis 15 15 15 31.4 31.4 31.4 71.223 5.9835E-131 524890000 262760000 262130000 1758 IPI:IPI00023234.3 SUMO-activating enzyme subunit 2;Ubiquitin-like 1-activating enzyme E1B;Anthracycline-associated resistance ARX UBA2;SAE2;UBLE1B;HRIHFB2115 Q9UBT2 ENST00000246548 K10685 1 0.75082 2.0239 0.67814 0.98841 1.2923 0.85393 fn3;ig;I-set;Pkinase;PPAK;Titin_Z chromosome;condensed chromosome;condensed nuclear chromosome;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;nuclear chromosome;nuclear part;organelle;organelle part;Z disc actin binding;catalytic activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;small GTPase regulator activity DNA packaging;muscle contraction;muscle system process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein complex assembly;protein modification process;striated muscle contraction;system process 14 13 13 0.4 0.4 0.4 3829.8 3.5852E-09 148700000 74575000 74124000 1759 IPI:IPI00759542.1;IPI:IPI00759754.1;IPI:IPI00023283.3;IPI:IPI00179357.2;IPI:IPI00759637.1;IPI:IPI00952748.1;IPI:IPI00455173.4 Titin;Connectin;Rhabdomyosarcoma antigen MU-RMS-40.14 TTN Q8WZ42-8;Q8WZ42;Q8WZ42-1;Q8WZ42-2;Q8WZ42-7;Q8WZ42-4;Q8WZ42-5;Q8WZ42-3 ENST00000360870;ENST00000375038 7 0.76292 1.3923 0.81456 1.0271 0.96891 1.0771 PHD;zf-C2H2 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding apoptosis;cell death;induction of apoptosis;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 5 5 5 16.9 16.9 16.9 44.155 4.4955E-48 79635000 43686000 35948000 1760 IPI:IPI00023322.1 Zinc finger protein ubi-d4;Requiem;Apoptosis response zinc finger protein;D4, zinc and double PHD fingers family 2 DPF2;REQ;UBID4 Q92785 ENST00000252268 1 0.76706 1.4521 0.70585 0.92953 1.007 0.93971 Ribosomal_L4 intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;mitochondrion;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 6 6 6 24.4 24.4 24.4 34.919 1.3673E-108 247430000 130580000 116850000 1761 IPI:IPI00023334.1;IPI:IPI00107137.1 39S ribosomal protein L4, mitochondrial;L4mt;MRP-L4 MRPL4;CDABP0091;CGI-28 Q9BYD3-1;Q9BYD3;Q9BYD3-2 ENST00000253099;ENST00000307422;ENST00000393733 2 0.57417 1.2229 0.64454 0.76615 0.78239 0.87975 HEAT cell junction;cell-cell junction;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane part;non-membrane-bounded organelle;nuclear part;nucleoplasm;organelle;organelle part;tight junction binding;protein binding biological adhesion;cell adhesion;cellular process Tight junction 29 29 29 29.4 29.4 29.4 141.15 9.1752E-283 585690000 245720000 339970000 1763 IPI:IPI00023344.2;IPI:IPI00413614.3;IPI:IPI00556574.5 Symplekin SYMPK;SPK Q92797-1;Q92797 ENST00000245934 K06100 3 0.66513 1.3823 0.67467 0.86545 0.96378 0.87539 Acyl_transf_1 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle [acyl-carrier-protein] S-malonyltransferase activity;acyltransferase activity;binding;catalytic activity;fatty-acid synthase activity;malonyltransferase activity;S-acyltransferase activity;S-malonyltransferase activity;transferase activity biosynthetic process;cellular process;fatty acid biosynthetic process;fatty acid metabolic process;lipid biosynthetic process;lipid metabolic process;metabolic process;organic acid biosynthetic process;organic acid metabolic process Fatty acid biosynthesis 8 8 8 26.4 26.4 26.4 42.961 2.3699E-184 82045000 44310000 37735000 1764 IPI:IPI00023359.1;IPI:IPI00163960.1 Malonyl CoA-acyl carrier protein transacylase, mitochondrial;Mitochondrial malonyltransferase MCAT;MT Q8IVS2-1;Q8IVS2 ENST00000290429;ENST00000327555 K00645 2 0.90544 1.5913 0.89449 1.1221 1.0933 1.1107 Cyto_heme_lyase cell part;cytoplasmic part;intracellular organelle part;intracellular part;membrane;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part binding;carbon-sulfur lyase activity;catalytic activity;cation binding;holocytochrome-c synthase activity;ion binding;iron ion binding;lyase activity;metal ion binding;transition metal ion binding anatomical structure morphogenesis;developmental process;metabolic process;organ morphogenesis;oxidation reduction Porphyrin and chlorophyll metabolism 6 6 6 23.1 23.1 23.1 30.601 9.588E-58 71725000 37236000 34489000 1765 IPI:IPI00023406.1 Cytochrome c-type heme lyase;Holocytochrome c-type synthase HCCS;CCHL P53701 ENST00000321143;ENST00000380762;ENST00000380763 K01764 1 0.65216 1.245 0.58228 0.88258 0.81924 0.76812 Nckap1 cell fraction;cell part;insoluble fraction;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane fraction;membrane part;plasma membrane part 7 7 7 7.4 7.4 7.4 128.15 8.6183E-45 235000000 130090000 104910000 1766 IPI:IPI00023407.4 Nck-associated protein 1-like;Membrane-associated protein HEM-1;Hematopoietic protein 1 NCKAP1L;HEM1 P55160 ENST00000293373 1 0.65851 2.7474 0.85101 0.91998 1.805 1.1582 Smg4_UPF3 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;nucleocytoplasmic transporter activity;nucleotide binding;protein binding;RNA binding;transporter activity nuclear mRNA splicing, via spliceosome;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 4 4 4 8.5 8.5 8.5 57.761 5.3744E-12 33315000 17408000 15907000 1767 IPI:IPI00023409.1;IPI:IPI00074183.3 Regulator of nonsense transcripts 3B;Nonsense mRNA reducing factor 3B;Up-frameshift suppressor 3 homolog B UPF3B;RENT3B;UPF3X Q9BZI7-1;Q9BZI7;Q9BZI7-2 ENST00000276201;ENST00000345865 2 0.83111 1.6572 0.84659 1.1016 1.0782 1.1285 Ras cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;early endosome membrane;endosome membrane;intracellular organelle;melanosome;membrane;membrane-bounded organelle;membrane-bounded vesicle;organelle;organelle membrane;plasma membrane;vesicle binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity cell communication;cellular component organization;cellular process;endocytosis;intracellular signaling cascade;membrane invagination;membrane organization;protein transport;signal transduction;small GTPase mediated signal transduction;transport Amyotrophic lateral sclerosis (ALS) 7 4 4 36.3 21.4 21.4 23.658 1.3042E-66 107140000 57914000 49227000 1771 IPI:IPI00023510.1 Ras-related protein Rab-5A RAB5A;RAB5 P20339 ENST00000273047 K07887 1 0.99825 1.9259 0.76547 1.3249 1.2211 1.0534 PA;zf-C3HC4 cell part;endomembrane system;integral to membrane;intrinsic to membrane;membrane part binding;catalytic activity;cation binding;ion binding;ligase activity;metal ion binding;protein binding;transition metal ion binding;zinc ion binding catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 2 2 2 5.4 5.4 5.4 38.298 0.00016062 21931000 11681000 10250000 1772 IPI:IPI00023511.1 E3 ubiquitin-protein ligase RNF167;RING finger protein 167;RING105 RNF167;LP2254 Q9H6Y7 ENST00000262482;ENST00000381350 1 0.95118 1.7658 0.93597 1.2496 1.1345 1.2401 Ras cell part;cytoplasmic part;Golgi apparatus part;Golgi membrane;intracellular organelle part;intracellular part;membrane;organelle membrane;organelle part binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity cell communication;intracellular signaling cascade;metabolic process;one-carbon metabolic process;protein amino acid methylation;protein modification process;signal transduction;small GTPase mediated signal transduction;transport 12 12 6 49.5 49.5 27.4 23.593 1.374E-118 710490000 337860000 372630000 1773 IPI:IPI00023526.4;IPI:IPI00217943.3 Ras-related protein Rab-6A RAB6A;RAB6 P20340-1;P20340;P20340-2 ENST00000310653;ENST00000336083 K07893 2 0.17889 0.33481 0.16438 0.21889 0.22783 0.20724 Pkinase cell projection;cyclin-dependent protein kinase holoenzyme complex;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;protein complex;ruffle ATP binding;binding;catalytic activity;cyclin-dependent protein kinase activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding G1 phase of mitotic cell cycle;phosphorus metabolic process;positive regulation of cell-matrix adhesion;protein amino acid phosphorylation;protein modification process;regulation of cell-matrix adhesion;regulation of immune system process Cell cycle;Chronic myeloid leukemia;Glioma;Melanoma;Non-small cell lung cancer;p53 signaling pathway;Pancreatic cancer;Pathways in cancer;Small cell lung cancer 17 16 16 57.1 54.6 54.6 36.938 0 1026000000 710350000 315670000 1774 IPI:IPI00023529.1 Cell division protein kinase 6;Serine/threonine-protein kinase PLSTIRE CDK6 Q00534 ENST00000265734 K02091 1 0.42978 0.88328 0.40806 0.59104 0.57188 0.54452 Pkinase axon;cell projection;cell soma;dendrite;growth cone;intracellular membrane-bounded organelle;intracellular organelle;lamellipodium;membrane;membrane-bounded organelle;neuromuscular junction;neuron projection;nucleus;organelle;site of polarized growth catalytic activity;cyclin-dependent protein kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;receptor signaling protein activity;signal transducer activity cell cycle;cell proliferation;cellular process;developmental process;embryonic development;positive regulation of apoptosis;positive regulation of cell death;regulation of apoptosis;regulation of cell death;regulation of programmed cell death Alzheimer's disease;Axon guidance 17 16 16 59.6 56.8 56.8 33.304 1.3379E-230 358280000 207350000 150920000 1775 IPI:IPI00023530.7 Cell division protein kinase 5;Cyclin-dependent kinase 5;Tau protein kinase II catalytic subunit;Serine/threonine-protein kinase PSSALRE CDK5 Q00535 ENST00000297518 K02090 1 0.88838 2.0238 0.87258 1.2037 1.2669 1.2009 EMP24_GP25L cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;ER-Golgi intermediate compartment;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part establishment of localization;transport 9 9 8 34 34 34 27.277 2.0382E-111 542760000 284130000 258630000 1776 IPI:IPI00023542.6 Transmembrane emp24 domain-containing protein 9;Glycoprotein 25L2 TMED9;GP25L2 Q9BVK6 ENST00000332598 1 0.88466 1.3482 0.93888 1.1089 0.94566 1.1935 Oxysterol_BP;PH binding;protein binding biosynthetic process;cellular biosynthetic process;cellular lipid metabolic process;cellular metabolic process;cellular process;lipid metabolic process;lipid transport;metabolic process;primary metabolic process;steroid metabolic process;transport 3 3 3 3.7 3.7 3.7 101.22 1.7017E-16 15003000 7833000 7170300 1778 IPI:IPI00023555.1;IPI:IPI00167053.1;IPI:IPI00162669.1;IPI:IPI00162670.1;IPI:IPI00169299.1;IPI:IPI00169296.1;IPI:IPI00375694.1;IPI:IPI00375695.1 Oxysterol-binding protein-related protein 3 OSBPL3;KIAA0704;ORP3;OSBP3 Q9H4L5-1;Q9H4L5;Q9H4L5-2;Q9H4L5-3;Q9H4L5-4 ENST00000313367;ENST00000352860;ENST00000353930 8 0.53907 1.1973 NaN 0.71711 0.73094 NaN Ssu72 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;phosphatase activity;phosphoprotein phosphatase activity;phosphoric ester hydrolase activity cellular biopolymer metabolic process;cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing 4 4 4 25.3 25.3 25.3 22.574 1.4302E-26 37400000 19272000 18128000 1779 IPI:IPI00023556.3;IPI:IPI00073512.3 RNA polymerase II subunit A C-terminal domain phosphatase SSU72 SSU72;HSPC182;PNAS-120 Q9NP77-1;Q9NP77;Q9NP77-2 ENST00000291386 2 NaN 0.98059 NaN NaN 0.6378 NaN Peptidase_C48 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle catalytic activity;cysteine-type peptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 2 2 2 2.9 2.9 2.9 126.14 0.00019381 2093200 1142200 950990 1780 IPI:IPI00023586.6;IPI:IPI00747900.2 Sentrin-specific protease 6;Sentrin/SUMO-specific protease SENP6;SUMO-1-specific protease 1 SENP6;KIAA0797;SSP1;SUSP1;FKSG6 Q9GZR1-1;Q9GZR1;Q9GZR1-2 ENST00000327284;ENST00000370014 K08595 2 0.80229 1.661 0.78638 1.0701 1.056 1.0378 PurA chromosomal part;chromosome, telomeric region;DNA replication factor A complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear chromosome part;nuclear chromosome, telomeric region;nuclear part;organelle part;protein complex DNA binding;double-stranded DNA binding;double-stranded telomeric DNA binding;nucleic acid binding;RNA polymerase II transcription factor activity;single-stranded DNA binding;transcription factor activity biosynthetic process;DNA metabolic process;DNA replication initiation;DNA unwinding during replication;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription 11 11 8 31.7 31.7 27 34.91 7.7323E-78 142370000 77185000 65181000 1781 IPI:IPI00023591.1;IPI:IPI00002534.2;IPI:IPI00383017.2 Transcriptional activator protein Pur-alpha;Purine-rich single-stranded DNA-binding protein alpha PURA;PUR1 Q00577 ENST00000331327 3 0.76011 1.5391 0.70704 1.1501 0.99415 0.9111 Tubulin;Tubulin_C cell part;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;microtubule;organelle part;protein complex binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;pyrophosphatase activity;structural molecule activity anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;microtubule-based movement;microtubule-based process;protein complex assembly Gap junction 30 8 8 69.4 18.9 18.9 49.585 0 379920000 202300000 177620000 1782 IPI:IPI00023598.2 Tubulin beta-4 chain;Tubulin 5 beta TUBB4;TUBB5 P04350 ENST00000264071 K07375 1 0.60535 1.0311 NaN 0.74023 0.66735 NaN Pkinase cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle catalytic activity;magnesium ion binding;MAP kinase kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;protein serine/threonine/tyrosine kinase activity;purine nucleoside binding cell communication;intracellular signaling cascade;MAPKKK cascade;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein kinase cascade;protein modification process;response to stress;signal transduction ErbB signaling pathway;Fc epsilon RI signaling pathway;GnRH signaling pathway;MAPK signaling pathway;T cell receptor signaling pathway;Toll-like receptor signaling pathway 5 5 5 14.7 14.7 14.7 49.07 5.0232E-09 6200100 3354400 2845700 1784 IPI:IPI00745806.3;IPI:IPI00794495.2;IPI:IPI00023636.3;IPI:IPI00302112.1 Dual specificity mitogen-activated protein kinase kinase 7;MAPK/ERK kinase 7;JNK-activating kinase 2;c-Jun N-terminal kinase kinase 2 MAP2K7;JNKK2;MEK7;MKK7;PRKMK7 O14733-3;O14733;O14733-4;O14733-1;O14733-2 ENST00000397979;ENST00000397981;ENST00000397983 K04431 4 0.78022 1.3428 0.80818 0.98141 0.89886 1.0283 dsDNA_bind binding;DNA binding;nucleic acid binding apoptosis;cell death;cellular process;death;induction of apoptosis;induction of programmed cell death;positive regulation of apoptosis;positive regulation of cell death;programmed cell death;regulation of apoptosis;regulation of cell death 6 6 6 45.6 45.6 45.6 14.285 1.026E-62 2010800000 1068200000 942530000 1785 IPI:IPI00023640.3 Programmed cell death protein 5;TF-1 cell apoptosis-related protein 19 PDCD5;TFAR19 O14737 ENST00000221784 K06875 1 0.73898 1.6495 0.72674 0.97071 1.058 0.97989 ThiF;UBA_e1_C;UBA_e1_thiolCys;UBACT cell part;cytoplasm;intracellular part adenyl nucleotide binding;ATP binding;binding;catalytic activity;ligase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;purine nucleotide binding;ribonucleotide binding;small protein activating enzyme activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;protein modification process;proteolysis Ubiquitin mediated proteolysis 18 18 18 19.6 19.6 19.6 117.97 1.1192E-156 151150000 84174000 66980000 1786 IPI:IPI00023647.4;IPI:IPI00827491.1;IPI:IPI00828006.1;IPI:IPI00827864.1 Ubiquitin-like modifier-activating enzyme 6;Ubiquitin-activating enzyme E1-like protein 2;Monocyte protein 4 UBA6;MOP4;UBE1L2 A0AVT1-1;A0AVT1;A0AVT1-2 ENST00000322244 K10699 4 0.50137 1.0933 0.5658 0.67934 0.72524 0.71428 11 11 7 8.8 8.8 5.1 154.31 4.2367E-115 71239000 40447000 30792000 1787 IPI:IPI00023649.3;IPI:IPI00879170.1;IPI:IPI00879441.1;IPI:IPI00879053.1 Protein strawberry notch homolog 1;Monocyte protein 3 SBNO1;MOP3 A3KN83-1;A3KN83;A3KN83-2;A3KN83-3;A3KN83-4 ENST00000267176 4 0.13945 0.31292 0.13937 0.20274 0.19131 0.18617 Pkinase chromosome;condensed chromosome;condensed nuclear chromosome;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;nuclear chromosome;nucleoplasm;organelle;organelle part ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cell cycle checkpoint;DNA damage checkpoint;DNA metabolic process;DNA recombination;DNA repair;DNA replication;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of cyclin-dependent protein kinase activity Cell cycle;Cell cycle - yeast;p53 signaling pathway 13 13 13 25.8 25.8 25.8 54.419 8.9789E-106 89537000 56857000 32680000 1788 IPI:IPI00023664.3 Serine/threonine-protein kinase Chk1 CHEK1;CHK1 O14757 ENST00000278916 K02216 1 1.1144 1.8384 1.2229 1.4983 1.1061 1.4811 LIM cell junction;cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane part;membrane-bounded organelle;nucleus;organelle;plasma membrane part binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding biological adhesion;cell adhesion;cellular process 5 5 5 10.9 10.9 10.9 65.746 8.2933E-26 25646000 12774000 12872000 1789 IPI:IPI00023704.1 Lipoma-preferred partner;LIM domain-containing preferred translocation partner in lipoma LPP Q93052 ENST00000312675 1 0.71573 1.8765 0.78622 0.94846 1.1363 1.0362 Peptidase_C26 cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;extracellular space;intracellular membrane-bounded organelle;intracellular organelle;lysosome;lytic vacuole;melanosome;membrane-bounded organelle;membrane-bounded vesicle;organelle;vacuole;vesicle catalytic activity;exopeptidase activity;gamma-glutamyl-peptidase activity;hydrolase activity;omega peptidase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;glutamine family amino acid metabolic process;glutamine metabolic process;metabolic process;nitrogen compound metabolic process;organic acid metabolic process Folate biosynthesis 7 7 7 27.7 27.7 27.7 35.964 1.1828E-120 595010000 128130000 466870000 1790 IPI:IPI00023728.1 Gamma-glutamyl hydrolase;Gamma-Glu-X carboxypeptidase;Conjugase;GH GGH Q92820 ENST00000260118 K01307 1 0.67051 1.3443 0.69143 0.90033 0.88397 0.91605 NAC;UBA cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nascent polypeptide-associated complex;nucleus;organelle;protein complex binding;DNA binding;nucleic acid binding biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein transport;transcription;translation;transport 4 4 4 25.6 25.6 25.6 23.384 2.4845E-185 1983000000 1046800000 936160000 1791 IPI:IPI00023748.3;IPI:IPI00012479.1 Nascent polypeptide-associated complex subunit alpha;Alpha-NAC NACA;HSD48 Q13765 ENST00000356769;ENST00000393891 K03626 2 1.0157 1.558 NaN 1.2833 1.0835 NaN Glycos_transf_2 cell part;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part binding;catalytic activity;hyaluronan synthase activity;protein binding;transferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring hexosyl groups;UDP-glycosyltransferase activity aminoglycan biosynthetic process;aminoglycan metabolic process;carbohydrate metabolic process;cell adhesion;glycosaminoglycan biosynthetic process;nitrogen compound metabolic process;polysaccharide biosynthetic process;polysaccharide metabolic process 2 2 2 5.4 5.4 5.4 64.831 0.0017662 127270000 64083000 63191000 1792 IPI:IPI00023768.2 Hyaluronan synthase 1;Hyaluronate synthase 1;Hyaluronic acid synthase 1 HAS1;HAS Q92839 ENST00000222115 K00752 1 0.85959 1.4957 0.92221 1.0216 1.0577 1.1631 CN_hydrolase cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle catalytic activity;hydrolase activity;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles;nitrilase activity metabolic process;nitrogen compound metabolic process 8 8 8 28.9 28.9 28.9 40.2 7.9696E-79 144820000 74168000 70654000 1793 IPI:IPI00456664.1;IPI:IPI00023779.1;IPI:IPI00456665.1;IPI:IPI00456663.1 Nitrilase homolog 1 NIT1 Q86X76-3;Q86X76;Q86X76-1;Q86X76-4;Q86X76-2 ENST00000368007;ENST00000368009 K01506 4 0.59403 1.7198 0.60405 0.81748 1.1361 0.80631 DnaJ cytoplasmic membrane-bounded vesicle;cytoplasmic part;cytoplasmic vesicle;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;melanosome;membrane;membrane-bounded organelle;membrane-bounded vesicle;organelle;vesicle binding;heat shock protein binding;protein binding;unfolded protein binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 2 2 2 7.6 7.6 7.6 22.149 1.3395E-14 28890000 16652000 12239000 1794 IPI:IPI00402231.1;IPI:IPI00023780.3 DnaJ homolog subfamily C member 5;Cysteine string protein DNAJC5;CSP Q9H3Z4-1;Q9H3Z4;Q9H3Z4-2 ENST00000360864;ENST00000369911 K09525 2 0.73692 1.5026 0.86352 0.91027 1.104 1.0682 cell part;integral to membrane;intrinsic to membrane;membrane;membrane part;plasma membrane defense response;response to stimulus;response to stress 3 3 3 14.1 14.1 14.1 21.196 2.139E-08 209140000 113240000 95902000 1795 IPI:IPI00023786.1 Protein tyrosine phosphatase receptor type C-associated protein;CD45-associated protein;Lymphocyte phosphatase-associated phosphoprotein PTPRCAP;LPAP Q14761 ENST00000326294 1 1.0509 1.7726 1.0905 1.3374 1.2345 1.4769 ig;PSI;Sema cell part;integral to membrane;intrinsic to membrane;membrane part binding;molecular transducer activity;protein binding;receptor activity;receptor binding;signal transducer activity anti-apoptosis;biological adhesion;cell adhesion;cellular process;immune response;immune system process;negative regulation of apoptosis;regulation of apoptosis;regulation of cell death;regulation of programmed cell death Axon guidance 5 5 5 7.8 7.8 7.8 96.149 2.0679E-09 60560000 29458000 31102000 1796 IPI:IPI00023807.3 Semaphorin-4D;BB18;A8;GR3 SEMA4D;CD100;SEMAJ Q92854 ENST00000343780;ENST00000356444 K06521 1 0.8628 1.1424 NaN 1.1621 0.71959 NaN Bromodomain;EPL1;PHD;PWWP cell part;histone acetyltransferase complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transition metal ion binding;zinc ion binding chromatin organization;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein amino acid acetylation;protein modification process;regulation of transcription, DNA-dependent;transcription 2 2 2 1.7 1.7 1.7 138.18 7.8009E-07 3525500 1819600 1705900 1798 IPI:IPI00456620.1;IPI:IPI00023856.2;IPI:IPI00926602.1;IPI:IPI00925976.1 Peregrin;Bromodomain and PHD finger-containing protein 1;BR140 protein BRPF1;BR140 P55201-2;P55201;P55201-1;P55201-3;P55201-4 ENST00000302054;ENST00000383829 4 0.68575 1.2342 0.67357 0.86887 0.81659 0.83908 NAP chromatin assembly complex;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;intracellular membrane-bounded organelle;intracellular organelle;macromolecular complex;melanosome;membrane-bounded organelle;membrane-bounded vesicle;organelle;vesicle binding;protein binding chromatin organization;DNA metabolic process;DNA replication;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleosome assembly;organelle organization 9 7 7 22.5 19.9 19.9 45.374 0 2264800000 1192700000 1072100000 1799 IPI:IPI00023860.1 Nucleosome assembly protein 1-like 1;NAP-1-related protein NAP1L1;NRP P55209 ENST00000261182;ENST00000393263 K11279 1 0.77733 1.4038 0.67839 1.0502 0.97348 0.93639 Peptidase_C14 cell part;cytoplasm;intracellular part binding;catalytic activity;cysteine-type endopeptidase activity;cysteine-type peptidase activity;endopeptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides;protein binding apoptosis;catabolic process;cell death;cellular process;induction of apoptosis;macromolecule catabolic process;metabolic process;positive regulation of cell death;programmed cell death;proteolysis;regulation of cell death Apoptosis 12 12 12 37.9 37.9 37.9 33.31 1.1625E-125 299040000 174820000 124210000 1800 IPI:IPI00023876.4;IPI:IPI00217208.1 Caspase-6;Apoptotic protease Mch-2;Caspase-6 subunit p18;Caspase-6 subunit p11 CASP6;MCH2 P55212-1;P55212 ENST00000265164;ENST00000352981 K04396 2 0.79755 1.6472 0.77515 1.027 1.0788 1.008 AAA cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;proteasome complex;protein complex ATP binding;binding;catalytic activity;G-protein-coupled receptor binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;receptor binding;transcription cofactor activity;transcription factor binding nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;proteolysis;regulation of transcription, DNA-dependent;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent Proteasome 23 23 22 62.8 62.8 59.9 45.626 0 1939200000 1040400000 898850000 1801 IPI:IPI00023919.4 26S protease regulatory subunit 8;Proteasome 26S subunit ATPase 5;Proteasome subunit p45;p45/SUG;Thyroid hormone receptor-interacting protein 1 PSMC5;SUG1 P62195 ENST00000310144 K03066 1 0.80832 1.1181 0.83477 1.0093 0.81663 1.0383 Mss4 binding;cation binding;enzyme regulator activity;GTPase regulator activity;guanyl-nucleotide exchange factor activity;ion binding;metal ion binding;nucleoside-triphosphatase regulator activity;transition metal ion binding;zinc ion binding cell communication;cellular component organization;cellular process;intracellular signaling cascade;membrane fusion;membrane organization;protein transport;signal transduction;small GTPase mediated signal transduction;transport 2 2 2 16.3 16.3 16.3 13.839 9.2664E-10 125460000 64991000 60473000 1802 IPI:IPI00023939.1 Guanine nucleotide exchange factor MSS4;Rab-interacting factor RABIF;MSS4;RASGRF3 P47224 ENST00000367262 1 0.62206 1.0545 0.57536 0.8037 0.72049 0.74203 DEAD;Helicase_C cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part ATP binding;ATP-dependent helicase activity;binding;catalytic activity;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity;RNA binding Folate biosynthesis 11 11 11 32.3 32.3 32.3 50.646 2.4559E-177 428120000 238760000 189360000 1803 IPI:IPI00023972.5 Probable ATP-dependent RNA helicase DDX47;DEAD box protein 47 DDX47 Q9H0S4 ENST00000358007 K01529 1 0.71996 1.2837 0.64007 0.88142 0.90421 0.77822 DNA_RNApol_7kD cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;catalytic activity;DNA binding;DNA-directed RNA polymerase activity;nucleic acid binding;nucleotidyltransferase activity;RNA polymerase activity;transferase activity;transferase activity, transferring phosphorus-containing groups;zinc ion binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile;transcription Huntington's disease;RNA polymerase 2 2 2 43.1 43.1 43.1 7.0041 4.6113E-05 77881000 43078000 34803000 1804 IPI:IPI00023975.1 DNA-directed RNA polymerases I, II, and III subunit RPABC4;DNA-directed RNA polymerase II subunit K;RPB10alpha;DNA-directed RNA polymerases I, II, and III 7.0 kDa polypeptide;RPB7.0;ABC10-alpha POLR2K P53803 ENST00000353107 K03009 1 0.82174 1.5138 0.80261 1.1205 1.007 1.0718 DFP acid-amino acid ligase activity;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;phosphopantothenate--cysteine ligase activity Pantothenate and CoA biosynthesis 6 6 6 19 19 19 34.005 8.3269E-19 92895000 50774000 42121000 1805 IPI:IPI00023987.5 Phosphopantothenate--cysteine ligase;Phosphopantothenoylcysteine synthetase PPCS;COAB Q9HAB8 ENST00000372561 K01922 1 0.77282 1.405 0.75067 1.02 0.93908 0.96541 HEAT;Pkinase_Tyr;WD40 cell part;cytoplasmic part;cytosol;intracellular part ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;protein tyrosine kinase activity;purine nucleoside binding;transferase activity cellular biopolymer metabolic process;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process Regulation of autophagy 9 9 9 7.4 7.4 7.4 153.1 4.3336E-103 43104000 23919000 19186000 1806 IPI:IPI00024006.3 Phosphoinositide 3-kinase regulatory subunit 4;PI3-kinase p150 subunit;Phosphoinositide 3-kinase adaptor protein PIK3R4 Q99570 ENST00000356763 K08333 1 0.78612 1.4239 NaN 0.98068 1.0651 NaN CH actin cytoskeleton;cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle actin binding;binding;cytoskeletal protein binding;protein binding;structural constituent of muscle;structural molecule activity anatomical structure development;developmental process;multicellular organismal process;muscle contraction;muscle organ development;muscle system process;organ development;smooth muscle contraction;system process 3 3 3 4 4 4 102.27 0.0026519 104580000 55127000 49455000 1807 IPI:IPI00374721.3;IPI:IPI00024007.3;IPI:IPI00219460.2;IPI:IPI00883637.1;IPI:IPI00909085.1;IPI:IPI00376001.3 Smoothelin SMTN;SMSMO P53814-6;P53814;P53814-1;P53814-3;P53814-4;P53814-5 ENST00000329852;ENST00000333137;ENST00000347557;ENST00000358743 6 1.0135 NaN 1.0167 1.2675 NaN 1.2482 Ank cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cyclin-dependent protein kinase inhibitor activity;cyclin-dependent protein kinase regulator activity;enzyme inhibitor activity;kinase inhibitor activity;kinase regulator activity;protein binding;protein kinase inhibitor activity DNA metabolic process;DNA synthesis during DNA repair;G1/S transition of mitotic cell cycle;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of cell growth;regulation of cyclin-dependent protein kinase activity Cell cycle 2 2 2 19.3 19.3 19.3 17.7 9.3958E-06 6877400 3328200 3549200 1808 IPI:IPI00024008.1 Cyclin-dependent kinase 4 inhibitor D;p19-INK4d CDKN2D P55273 ENST00000335766;ENST00000393599 K06623 1 NaN 1.4183 1.07 NaN 1.0102 1.2819 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;protein binding;RNA binding cell activation;cell communication;immune system process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;RNA processing 3 3 3 6.8 6.8 6.8 80.735 6.5067E-177 28265000 14588000 13677000 1809 IPI:IPI00024024.4;IPI:IPI00643565.1;IPI:IPI00845316.1 Splicing factor, arginine/serine-rich 17A;Protein XE7;B-lymphocyte antigen;721P SFRS17A;CXYorf3;DXYS155E;XE7 Q02040-1;Q02040;Q02040-3;Q02040-2 ENST00000313871 3 0.86992 1.6316 0.85665 1.1194 1.0786 1.0879 Clathrin;Clathrin_propel;Clathrin-link clathrin coat;clathrin coat of coated pit;clathrin coat of trans-Golgi network vesicle;clathrin vesicle coat;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;macromolecular complex;membrane coat;membrane-bounded vesicle;vesicle;vesicle coat binding;protein binding;structural molecule activity cellular process;establishment of localization;establishment of localization in cell;establishment of protein localization;intracellular protein transport;intracellular transport;protein transport;transport;vesicle-mediated transport Huntington's disease 85 85 64 52.3 52.3 41.1 191.61 0 13340000000 6908700000 6431500000 1810 IPI:IPI00024067.4;IPI:IPI00455383.4 Clathrin heavy chain 1;CLH-17 CLTC;CLH17;CLTCL2;KIAA0034 Q00610-1;Q00610;Q00610-2 ENST00000269122 K04646 2 0.76486 1.4887 0.87378 1.0643 0.96189 1.1673 HSF_DNA-bind;Vert_HS_TF cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;protein binding;sequence-specific DNA binding;transcription factor activity;transcription regulator activity biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;response to stress;transcription 5 5 5 12.3 12.3 12.3 57.26 1.8169E-29 49214000 20363000 28851000 1811 IPI:IPI00024071.1;IPI:IPI00218507.1 Heat shock factor protein 1;Heat shock transcription factor 1 HSF1;HSTF1 Q00613-1;Q00613;Q00613-2 ENST00000328245 K09414 2 0.53437 1.8442 NaN 0.67912 1.2788 NaN CBAH cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;lysosome;lytic vacuole;membrane-bounded organelle;organelle;vacuole catalytic activity;hydrolase activity lipid metabolic process;metabolic process;primary metabolic process 3 3 3 7.2 7.2 7.2 40.066 0.0013492 7211300 4018600 3192700 1812 IPI:IPI00024083.3;IPI:IPI00215844.1;IPI:IPI00028879.5 N-acylethanolamine-hydrolyzing acid amidase;N-acylsphingosine amidohydrolase-like;Acid ceramidase-like protein NAAA;ASAHL;PLT Q02083-1;Q02083;Q02083-2;Q02083-3 ENST00000286733;ENST00000399490;ENST00000399497 K01463 3 0.85476 1.2928 NaN 1.0017 0.92677 NaN Annexin cell part;cytoplasm;intracellular part binding;calcium ion binding;calcium-dependent phospholipid binding;cation binding;enzyme inhibitor activity;enzyme regulator activity;ion binding;lipid binding;phospholipase A2 inhibitor activity;phospholipase inhibitor activity;phospholipid binding biological regulation;cell communication;cellular process;regulation of biological process;regulation of cellular process;signal transduction 8 8 8 24.1 24.1 24.1 36.375 3.4639E-36 131390000 66057000 65330000 1813 IPI:IPI00024095.3 Annexin A3;Annexin-3;Annexin III;Lipocortin III;Placental anticoagulant protein III;35-alpha calcimedin;Inositol 1,2-cyclic phosphate 2-phosphohydrolase ANXA3;ANX3 P12429 ENST00000264908 K01124 1 0.50305 0.88826 0.57788 0.64046 0.56057 0.72588 WD40 cell part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;organelle part;pore complex;protein complex intracellular transport;nucleocytoplasmic transport;regulation of biological process;regulation of cellular process;regulation of intracellular transport;regulation of localization;regulation of nucleocytoplasmic transport;transport 11 11 11 27.7 27.7 27.7 59.573 2.4472E-171 227640000 130550000 97093000 1814 IPI:IPI00024143.4 Aladin;Adracalin AAAS;ADRACALA;GL003 Q9NRG9 ENST00000209873 1 0.52101 1.3954 0.53898 0.70815 0.84831 0.72099 TruB_N catalytic activity;intramolecular transferase activity;isomerase activity;pseudouridine synthase activity cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;pseudouridine synthesis;RNA modification;RNA processing;tRNA metabolic process;tRNA processing 3 3 3 10 10 10 36.694 4.2078E-07 13049000 7418400 5630700 1815 IPI:IPI00024151.3 Probable tRNA pseudouridine synthase 2 TRUB2 O95900 ENST00000372890 1 0.84448 1.8411 0.9131 1.1292 1.0994 1.1272 FKBP_C cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;cis-trans isomerase activity;drug binding;FK506 binding;isomerase activity;macrolide binding;molecular transducer activity;peptidyl-prolyl cis-trans isomerase activity;receptor activity;signal transducer activity biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 17 17 17 57.1 57.1 57.1 25.177 8.0008E-243 1641500000 846610000 794850000 1816 IPI:IPI00024157.1 FK506-binding protein 3;Peptidyl-prolyl cis-trans isomerase;25 kDa FKBP;FKBP-25;Rapamycin-selective 25 kDa immunophilin FKBP3;FKBP25 Q00688 ENST00000216330;ENST00000396062 K09570 1 0.61356 1.1226 0.65646 0.76601 0.76003 0.84724 RNA_pol_Rpb1_1;RNA_pol_Rpb1_2;RNA_pol_Rpb1_3;RNA_pol_Rpb1_4;RNA_pol_Rpb1_5 cell part;DNA-directed RNA polymerase complex;DNA-directed RNA polymerase III complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;RNA polymerase complex binding;catalytic activity;DNA binding;DNA-directed RNA polymerase activity;magnesium ion binding;nucleic acid binding;nucleotidyltransferase activity;transferase activity;transferase activity, transferring phosphorus-containing groups;zinc ion binding biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription;transcription, DNA-dependent RNA polymerase 8 7 7 7.4 6.8 6.8 155.75 3.0187E-72 48359000 27130000 21229000 1817 IPI:IPI00024163.1 DNA-directed RNA polymerase III subunit RPC1;DNA-directed RNA polymerase III subunit A;DNA-directed RNA polymerase III largest subunit;RPC155;RNA polymerase III subunit C160 POLR3A O14802 ENST00000372371 K03018 1 0.48597 1.1077 0.49935 0.68819 0.72965 0.66667 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;nucleoplasm;organelle;organelle part biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 10 10 10 12.6 12.6 12.6 98.795 5.3988E-36 63763000 37133000 26630000 1818 IPI:IPI00024167.1 ESF1 homolog;ABT1-associated protein ESF1;ABTAP;C20orf6;HDCMC28P Q9H501 ENST00000202816;ENST00000401775 1 0.85511 1.6225 0.81319 1.1205 1.0699 1.1149 Proteasome;Proteasome_A_N cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;proteasome core complex;protein complex binding;catalytic activity;endopeptidase activity;hydrolase activity;identical protein binding;peptidase activity;peptidase activity, acting on L-amino acid peptides;protein binding;threonine-type endopeptidase activity;threonine-type peptidase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Proteasome 15 15 15 56.9 56.9 56.9 27.887 0 5441000000 2856000000 2585000000 1819 IPI:IPI00024175.3;IPI:IPI00218372.1;IPI:IPI00154509.3;IPI:IPI00748423.1;IPI:IPI00219950.2 Proteasome subunit alpha type-7;Proteasome subunit RC6-1;Proteasome subunit XAPC7 PSMA7 O14818-1;O14818 ENST00000370873 K02731 5 0.64942 1.3076 0.71416 0.88262 0.85264 0.97621 Myb_DNA-binding;TRF Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;Mre11 complex;nuclear telomere cap complex;nucleoplasm;organelle;protein complex;protein-DNA complex;telomere cap complex binding;DNA binding;double-stranded DNA binding;double-stranded telomeric DNA binding;identical protein binding;nucleic acid binding;protein binding;protein C-terminus binding;protein homodimerization activity;telomeric DNA binding age-dependent telomere shortening;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;progressive alteration of chromatin during cell aging;progressive alteration of chromatin during replicative cell aging;telomere maintenance 10 10 10 26 26 26 55.55 3.7665E-59 131930000 70081000 61851000 1820 IPI:IPI00024214.1;IPI:IPI00216552.2 Telomeric repeat-binding factor 2;TTAGGG repeat-binding factor 2;Telomeric DNA-binding protein TERF2;TRBF2;TRF2 Q15554-1;Q15554;Q15554-2 ENST00000254942 K11111 2 0.91633 1.2963 0.91566 1.1534 0.94009 1.1418 G-patch;KOW cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding 8 8 8 23.7 23.7 23.7 52.228 1.5024E-171 109850000 51574000 58274000 1821 IPI:IPI00024255.2 G patch domain and KOW motifs-containing protein;G patch domain-containing protein 5;Protein MOS2 homolog;Protein T54 GPKOW;GPATC5;GPATCH5;T54 Q92917 ENST00000156109 1 0.75483 1.9466 0.77521 0.98611 1.1664 1.0502 MAPEG cell fraction;endoplasmic reticulum membrane;insoluble fraction;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane fraction;membrane part;microsome;organelle membrane;organelle part;vesicular fraction antioxidant activity;catalytic activity;glutathione transferase activity;oxidoreductase activity;oxidoreductase activity, acting on peroxide as acceptor;peroxidase activity;transferase activity biological regulation;cell communication;cellular process;lipid metabolic process;metabolic process;primary metabolic process;regulation of biological process;regulation of cellular process;signal transduction Drug metabolism - cytochrome P450;Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450 2 2 2 15.8 15.8 15.8 16.516 2.2613E-18 104400000 55063000 49338000 1823 IPI:IPI00024266.3 Microsomal glutathione S-transferase 3;Microsomal GST-III MGST3 O14880 ENST00000367883;ENST00000367884;ENST00000367885;ENST00000367886;ENST00000367889;ENST00000404549 K00799 1 0.56232 1.0957 NaN 0.7343 0.71449 NaN EGF;EGF_CA;Ldl_recept_a;Ldl_recept_b cell fraction;coated pit;insoluble fraction;integral to membrane;intrinsic to membrane;macromolecular complex;membrane fraction;plasma lipoprotein particle;protein-lipid complex;triglyceride-rich lipoprotein particle;very-low-density lipoprotein particle binding;calcium ion binding;lipoprotein binding;lipoprotein receptor activity;low-density lipoprotein binding;low-density lipoprotein receptor activity;protein binding;receptor activity;signal transducer activity;transmembrane receptor activity alcohol metabolic process;behavior;cell communication;endocytosis;learning or memory;lipid metabolic process;lipid transport;memory;metabolic process;nervous system development;signal transduction;steroid metabolic process;system process;transport 7 7 7 9.7 9.7 9.7 96.098 2.493E-66 10624000 5833900 4790400 1824 IPI:IPI00024273.1;IPI:IPI00219353.1 Very low-density lipoprotein receptor VLDLR P98155-1;P98155;P98155-2 ENST00000382099;ENST00000382100 2 0.4232 0.89915 0.46045 0.56166 0.57733 0.60431 BP28CT;HEAT cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;ribonucleoprotein complex binding;protein binding cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 42 42 42 24.4 24.4 24.4 242.37 0 333590000 192290000 141300000 1825 IPI:IPI00024279.4 HEAT repeat-containing protein 1;Protein BAP28 HEATR1;BAP28 Q9H583 ENST00000366582 1 1.0434 1.6422 0.94137 1.3315 1.1693 1.1874 Ras cell part;membrane;plasma membrane binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity cell communication;cellular process;establishment of protein localization;intracellular signaling cascade;protein transport;regulation of biological process;signal transduction;small GTPase mediated signal transduction;transport 11 5 5 56.5 30.4 30.4 23.584 2.4187E-216 172930000 87575000 85355000 1826 IPI:IPI00024282.1;IPI:IPI00060801.1;IPI:REV_IPI00045660.4 Ras-related protein Rab-8B RAB8B Q92930 ENST00000321437 K07902 3 0.88359 1.5139 0.87182 1.0817 0.98901 1.0977 Acyl-CoA_dh_1;Acyl-CoA_dh_M;Acyl-CoA_dh_N cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part acyl-CoA dehydrogenase activity;binding;catalytic activity;electron carrier activity;glutaryl-CoA dehydrogenase activity;nucleoside binding;nucleotide binding;oxidoreductase activity;protein binding;purine nucleoside binding metabolic process;oxidation reduction Benzoate degradation via CoA ligation;Fatty acid metabolism;Lysine degradation;Tryptophan metabolism 9 9 9 31.5 31.5 31.5 48.127 5.8257E-75 221110000 118420000 102700000 1828 IPI:IPI00024317.1;IPI:IPI00218112.1 Glutaryl-CoA dehydrogenase, mitochondrial GCDH Q92947-1;Q92947;Q92947-2 ENST00000222214 K00252 2 0.80632 1.5994 0.83648 1.0599 1.0839 1.065 RRM_1 binding;nucleic acid binding;nucleotide binding;RNA binding cellular biopolymer metabolic process;cellular process;macromolecule metabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing 8 8 8 58.6 58.6 58.6 17.17 8.3934E-269 1056700000 540830000 515910000 1829 IPI:IPI00024320.1 Putative RNA-binding protein 3;RNA-binding motif protein 3;RNPL RBM3;RNPL P98179 ENST00000376755;ENST00000376759 1 0.55664 1.0657 0.68103 0.71515 0.72919 0.87078 Clp1 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex;tRNA-intron endonuclease complex ATP binding;binding;catalytic activity;GTP binding;kinase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups nuclear mRNA splicing, via spliceosome;RNA splicing, via endonucleolytic cleavage and ligation;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 3 3 3 6.1 6.1 6.1 47.645 7.2892E-07 22171000 12944000 9226600 1830 IPI:IPI00024381.1 Polyribonucleotide 5'-hydroxyl-kinase Clp1;Polynucleotide kinase Clp1;Pre-mRNA cleavage complex II protein Clp1 CLP1;HEAB Q92989 ENST00000302731 1 0.59452 1.1524 0.6452 0.73504 0.7294 0.83549 UBA;UCH;zf-UBP cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;cysteine-type endopeptidase activity;cysteine-type peptidase activity;endopeptidase activity;hydrolase activity;peptidase activity;ubiquitin thiolesterase activity;ubiquitin-specific protease activity;zinc ion binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process 6 4 4 7 5.7 5.7 97.326 1.8404E-45 9921900 5154700 4767200 1831 IPI:IPI00024401.4 Ubiquitin carboxyl-terminal hydrolase 13;Ubiquitin thioesterase 13;Ubiquitin-specific-processing protease 13;Deubiquitinating enzyme 13;Isopeptidase T-3 USP13;ISOT3 Q92995 ENST00000263966 K11836 1 0.81877 1.6766 0.80612 1.0852 1.122 1.0299 C2;Copine cell part;cytoplasmic part;cytosol;intracellular part binding;calcium-dependent phospholipid binding;catalytic activity;kinase activity;lipid binding;phospholipid binding;protein kinase activity;protein serine/threonine kinase activity;transferase activity;transporter activity cellular process;establishment of localization;lipid metabolic process;metabolic process;primary metabolic process;transport;vesicle-mediated transport 15 15 14 30.2 30.2 28.5 60.13 6.4453E-149 548670000 291370000 257290000 1832 IPI:IPI00024403.1;IPI:IPI00002657.1;IPI:IPI00295469.5;IPI:IPI00219842.1;IPI:IPI00384746.2;IPI:IPI00219004.1;IPI:IPI00059186.1 Copine-3;Copine III CPNE3;CPN3;KIAA0636 O75131 ENST00000198765 7 0.76241 1.4504 0.73425 1.0409 1.0086 1.0111 ANTH;I_LWEQ clathrin coated vesicle membrane;coated pit;coated vesicle membrane;cytoplasmic part;cytoplasmic vesicle membrane;cytoplasmic vesicle part;intracellular part;membrane;membrane part;organelle membrane;organelle part;vesicle membrane actin binding;binding;cytoskeletal protein binding;lipid binding;phosphoinositide binding;phospholipid binding;protein binding cellular component organization;cellular process;endocytosis;establishment of localization;membrane invagination;membrane organization;receptor-mediated endocytosis;transport;vesicle-mediated transport 10 10 10 11.7 11.7 11.7 119.39 2.2409E-199 106510000 57644000 48863000 1833 IPI:IPI00024417.1;IPI:IPI00782965.2 Huntingtin-interacting protein 1-related protein;Hip 12 HIP1R;HIP12;KIAA0655 O75146 ENST00000253083 2 0.64363 1.3144 0.82078 0.85292 0.82946 1.0989 DHO_dh cell part;cytoplasmic part;intracellular organelle part;intracellular part;membrane;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part catalytic activity;dihydroorotate dehydrogenase activity;dihydroorotate oxidase activity;oxidoreductase activity;oxidoreductase activity, acting on the CH-CH group of donors;oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 'de novo' pyrimidine base biosynthetic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;pyrimidine base metabolic process;pyrimidine nucleoside metabolic process;pyrimidine nucleotide metabolic process Pyrimidine metabolism 3 3 3 10.4 10.4 10.4 42.867 5.1146E-129 29163000 15239000 13925000 1834 IPI:IPI00024462.3 Dihydroorotate dehydrogenase, mitochondrial;Dihydroorotate oxidase DHODH Q02127 ENST00000219240 K00254 1 0.902 1.9002 0.9516 1.1847 1.2554 1.195 UDP-g_GGTase endoplasmic reticulum;endoplasmic reticulum lumen;ER-Golgi intermediate compartment;intracellular membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;membrane-enclosed lumen;organelle;organelle lumen;organelle part binding;catalytic activity;protein binding;transferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring hexosyl groups;UDP-glucose:glycoprotein glucosyltransferase activity;UDP-glycosyltransferase activity carbohydrate metabolic process;cellular biopolymer metabolic process;cellular process;'de novo' protein folding;metabolic process;protein amino acid glycosylation;protein folding;protein metabolic process;protein modification process 33 33 32 28.6 28.6 28 177.19 0 933970000 492380000 441590000 1835 IPI:IPI00024466.2;IPI:IPI00619903.3 UDP-glucose:glycoprotein glucosyltransferase 1;UDP-glucose ceramide glucosyltransferase-like 1;UDP--Glc:glycoprotein glucosyltransferase;HUGT1 UGCGL1;GT;UGGT;UGT1;UGTR Q9NYU2-1;Q9NYU2;Q9NYU2-2 ENST00000259253 K11718 2 0.65224 NaN 0.71019 0.86205 NaN 0.93753 UBA;ubiquitin cytosol;endoplasmic reticulum membrane;endoplasmic reticulum part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane part;membrane-bounded organelle;nucleus;organelle;organelle membrane;organelle part binding;identical protein binding;protein binding 5 2 2 8.8 4.3 4.3 63.852 6.4897E-61 46960000 25208000 21751000 1836 IPI:IPI00024502.2 Ubiquilin-4;Ataxin-1 ubiquitin-like-interacting protein A1U UBQLN4;C1orf6;UBIN Q9NRR5 ENST00000368309 K04523 1 0.70391 1.5782 0.71735 0.95278 1.0449 0.95504 DnaJ cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle;perinuclear region of cytoplasm ATPase activator activity;ATPase regulator activity;binding;chaperone binding;enzyme activator activity;enzyme regulator activity;heat shock protein binding;nucleoside-triphosphatase regulator activity;protein binding cellular process;cytoskeleton organization;metabolic process;negative regulation of peptidase activity;organelle organization;protein folding;response to biotic stimulus;response to organic substance;response to stress;response to unfolded protein 2 2 2 8 8 8 36.087 7.6752E-46 6710400 3767100 2943300 1837 IPI:IPI00024523.2;IPI:IPI00556073.2;IPI:IPI00098523.1 DnaJ homolog subfamily B member 6;Heat shock protein J2;MSJ-1;HHDJ1;MRJ DNAJB6;HSJ2;MRJ;MSJ1 O75190-1;O75190;O75190-3;O75190-2 ENST00000262177 K09512 3 0.57667 0.72506 0.73838 0.73231 0.44284 0.98474 KH_1 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;nucleic acid binding;RNA binding 9 9 9 42.9 42.9 42.9 27.924 9.4282E-79 165530000 79176000 86353000 1838 IPI:IPI00024524.4 RNA-binding protein PNO1 PNO1 Q9NRX1 ENST00000263657 K11884 1 0.74834 1.2344 0.659 0.91785 0.84671 0.897 BAR;SH3_1 cell part;cytoplasm;intracellular part binding;protein binding 8 8 8 24 24 24 44.765 1.9106E-49 136940000 72761000 64182000 1839 IPI:IPI00398828.1;IPI:IPI00024540.3 Endophilin-B2;SH3 domain-containing GRB2-like protein B2 SH3GLB2;KIAA1848;PP578 Q9NR46-2;Q9NR46;Q9NR46-1 ENST00000372554;ENST00000372559;ENST00000372564 K11248 2 0.5436 1.658 0.63446 0.74715 1.0208 0.84119 DUF2246 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle 4 4 4 17.9 17.9 17.9 32.94 1.3606E-12 18798000 9960000 8838400 1840 IPI:IPI00024547.1 Methylmalonic aciduria and homocystinuria type D protein, mitochondrial MMADHC;C2orf25;CL25022;HSPC161;My011 Q9H3L0 ENST00000303319 1 0.82624 1.6282 0.78921 1.1687 1.0686 1.0775 DUF2012 cell part;cytoplasmic part;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane part;membrane-bounded organelle;mitochondrion;organelle binding;nucleotide binding;purine nucleotide binding 4 4 4 19.8 19.8 19.8 26.47 3.4002E-18 207850000 107480000 100380000 1841 IPI:IPI00024551.1 UPF0480 protein C15orf24 C15orf24;C11orf3;HT022;UNQ905/PRO1926 Q9NPA0 ENST00000256545 1 0.39374 1.0963 0.57708 0.5348 0.70031 0.76561 Nop53 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part 4 4 4 9 9 9 54.389 3.3892E-24 132900000 69506000 63395000 1842 IPI:IPI00024567.4 Glioma tumor suppressor candidate region gene 2 protein;p60 GLTSCR2 Q9NZM5 ENST00000246802 1 0.48191 1.0617 0.42031 0.64264 0.66396 0.61657 SAP;zf-C3HC4 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;cation binding;damaged DNA binding;DNA binding;ion binding;ligase activity;metal ion binding;nucleic acid binding;protein binding;transition metal ion binding;zinc ion binding catabolic process;DNA metabolic process;DNA repair;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;proteolysis;response to DNA damage stimulus;response to stress 5 5 5 13.1 13.1 13.1 56.194 5.8529E-24 24347000 14183000 10164000 1843 IPI:IPI00024579.1 E3 ubiquitin-protein ligase RAD18;Postreplication repair protein RAD18;RING finger protein 73 RAD18;RNF73 Q9NS91 ENST00000264926 K10627 1 0.78179 1.6496 NaN 1.0325 1.0776 NaN Biotin_carb_C;Biotin_lipoyl;CPSase_L_chain;CPSase_L_D2 cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part ATP binding;binding;biotin binding;catalytic activity;CoA carboxylase activity;ligase activity;ligase activity, forming carbon-carbon bonds;methylcrotonoyl-CoA carboxylase activity;nucleoside binding;nucleotide binding;purine nucleoside binding cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;leucine catabolic process;leucine metabolic process;organic acid metabolic process;vitamin metabolic process;water-soluble vitamin metabolic process Valine, leucine and isoleucine degradation 15 15 15 24.6 24.6 24.6 80.472 1.2293E-71 34032000 19900000 14132000 1844 IPI:IPI00024580.4 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial;3-methylcrotonyl-CoA carboxylase 1;3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha;3-methylcrotonyl-CoA carboxylase biotin-containing subunit MCCC1;MCCA Q96RQ3 ENST00000265594 K01968 1 NaN NaN 0.5809 NaN NaN 0.76884 DUF159 2 2 2 5.6 5.6 5.6 40.574 0.0046225 1087500 547200 540290 1845 IPI:IPI00024618.2 UPF0361 protein DC12 C3orf37;DC12 Q96FZ2 ENST00000383463;ENST00000389735 1 0.53667 1.3304 0.61061 0.8252 0.86537 0.89067 Cmc1 3 3 3 26.6 26.6 26.6 9.4598 2.969E-15 14126000 7459100 6667300 1846 IPI:IPI00024619.5 Uncharacterized protein C16orf61 C16orf61;DC13 Q9NRP2 ENST00000219400 1 0.81708 1.6692 NaN 1.1371 1.0614 NaN Acyl-CoA_dh_1;Acyl-CoA_dh_M;Acyl-CoA_dh_N cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part acyl-CoA dehydrogenase activity;binding;catalytic activity;electron carrier activity;nucleoside binding;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on the CH-CH group of donors;purine nucleoside binding carboxylic acid metabolic process;cellular ketone metabolic process;cellular process;fatty acid metabolic process;lipid metabolic process;metabolic process;monocarboxylic acid metabolic process;organic acid metabolic process;oxoacid metabolic process Fatty acid metabolism;Valine, leucine and isoleucine degradation 6 6 6 19.2 19.2 19.2 47.485 8.3853E-58 22079000 12083000 9995800 1848 IPI:IPI00024623.3 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial;2-methyl branched chain acyl-CoA dehydrogenase;2-methylbutyryl-coenzyme A dehydrogenase ACADSB P45954 ENST00000358776 K09478 1 0.74442 1.4642 0.78037 1.0163 1.0204 1.0701 DUF1682 cell part;integral to membrane;intrinsic to membrane;membrane part binding;protein binding 12 12 12 28.4 28.4 28.4 55.873 1.6798E-140 202740000 106880000 95855000 1849 IPI:IPI00024642.2;IPI:IPI00743775.1 Coiled-coil domain-containing protein 47 CCDC47;GK001;MSTP041;PSEC0077 Q96A33-1;Q96A33;Q96A33-2 ENST00000225726;ENST00000403162 2 0.65364 1.5326 0.70685 0.91199 0.90405 1.0087 MFS_1 cell fraction;cell part;insoluble fraction;integral to membrane;intrinsic to membrane;membrane;membrane fraction;membrane part;plasma membrane binding;mevalonate transmembrane transporter activity;monocarboxylic acid transmembrane transporter activity;organic acid transmembrane transporter activity;protein binding;secondary active transmembrane transporter activity;transporter activity anion transport;carboxylic acid transport;establishment of localization;ion transport;mevalonate transport;monocarboxylic acid transport;organic acid transport;organic anion transport;transport 6 6 6 7.8 7.8 7.8 53.958 3.4583E-43 283620000 150260000 133360000 1850 IPI:IPI00024650.1 Monocarboxylate transporter 1;Solute carrier family 16 member 1 SLC16A1;MCT1 P53985 ENST00000369626 K08179 1 0.90245 1.6822 0.96276 1.279 1.0586 1.2463 DUF292 cell part;cytoplasmic part;cytoplasmic vesicle;ER-Golgi intermediate compartment;intracellular organelle;intracellular part;organelle;vesicle binding;protein binding cell cycle;cell division;cellular process 8 8 8 20.2 20.2 20.2 39.978 1.068E-23 460020000 234720000 225300000 1851 IPI:IPI00939709.1;IPI:IPI00024660.1;IPI:IPI00420088.1;IPI:IPI00643007.1 IST1 homolog;Putative MAPK-activating protein PM28 KIAA0174;IST1 P53990-4;P53990;P53990-1;P53990-2;P53990-3 ENST00000329908;ENST00000378798;ENST00000378799 4 0.97048 1.7272 0.94444 1.2202 1.1522 1.1832 Gelsolin;Sec23_BS;Sec23_helical;Sec23_trunk;zf-Sec23_Sec24 COPII vesicle coat;endoplasmic reticulum membrane;endoplasmic reticulum part;Golgi apparatus part;intracellular part;macromolecular complex;membrane;membrane coat;membrane part;organelle membrane;organelle part;protein complex;vesicle coat binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding cellular component organization;cellular process;ER to Golgi vesicle-mediated transport;establishment of protein localization;intracellular protein transport;membrane organization;protein transport;transport;vesicle-mediated transport 25 24 23 30.6 30.1 28.7 118.32 0 608080000 319830000 288250000 1852 IPI:IPI00024661.5 Protein transport protein Sec24C;SEC24-related protein C SEC24C;KIAA0079 P53992 ENST00000339365;ENST00000345254 1 0.73712 1.5946 0.71827 1.0878 0.9923 1.0265 Chromo;Chromo_shadow centromeric heterochromatin;chromatin;envelope;heterochromatin;intracellular organelle;non-membrane-bounded organelle;nuclear centromeric heterochromatin;nuclear chromatin;nuclear envelope;nuclear heterochromatin;nucleolus;organelle;organelle envelope binding;chromatin binding;general transcriptional repressor activity;protein binding;transcription regulator activity;transcription repressor activity cellular process;chromatin assembly or disassembly;chromatin organization;negative regulation of biosynthetic process;negative regulation of metabolic process;organelle organization;regulation of biosynthetic process;regulation of gene expression 11 11 10 51.8 51.8 45.5 22.225 1.2686E-169 559410000 291730000 267690000 1853 IPI:IPI00024662.1 Chromobox protein homolog 5;Heterochromatin protein 1 homolog alpha;Antigen p25 CBX5;HP1A P45973 ENST00000209875 K11587 1 0.93205 1.8799 1.0091 1.2682 1.2142 1.2787 UBA;UCH;zf-UBP cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;lysosome;lytic vacuole;membrane-bounded organelle;nucleus;organelle;vacuole binding;catalytic activity;cysteine-type endopeptidase activity;cysteine-type peptidase activity;endopeptidase activity;hydrolase activity;peptidase activity;protein binding;ubiquitin thiolesterase activity;zinc ion binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process 18 18 16 28.2 28.2 26.9 95.785 0 573170000 299700000 273480000 1854 IPI:IPI00024664.1;IPI:IPI00375145.1 Ubiquitin carboxyl-terminal hydrolase 5;Ubiquitin thioesterase 5;Ubiquitin-specific-processing protease 5;Deubiquitinating enzyme 5;Isopeptidase T USP5;ISOT P45974-1;P45974;P45974-2 ENST00000229268;ENST00000389231 K11836 2 0.71768 1.6543 0.70254 0.93731 1.0882 1.0132 TB2_DP1_HVA22 cell part;integral to membrane;intrinsic to membrane;membrane part binding;protein binding 4 4 4 12.7 12.7 12.7 21.493 6.4153E-16 147420000 97794000 49629000 1855 IPI:IPI00024670.5 Receptor expression-enhancing protein 5;Polyposis locus protein 1;TB2 protein REEP5;C5orf18;DP1;TB2 Q00765 ENST00000379638 1 0.55867 2.1221 0.5253 0.78402 1.3676 0.70363 Pkinase catalytic activity;JUN kinase activity;MAP kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;receptor signaling protein serine/threonine kinase activity MAPKKK cascade;phosphorus metabolic process;positive regulation of myeloid leukocyte differentiation;protein amino acid phosphorylation;protein modification process;regulation of immune system process;regulation of myeloid leukocyte differentiation 6 5 2 15.3 13.4 5.4 48.139 6.0216E-54 31950000 19583000 12367000 1856 IPI:IPI00024673.2;IPI:IPI00303550.2;IPI:IPI00220382.2;IPI:IPI00220383.2 Mitogen-activated protein kinase 9;Stress-activated protein kinase JNK2;c-Jun N-terminal kinase 2;JNK-55 MAPK9;JNK2;PRKM9 P45984-1;P45984;P45984-4;P45984-2;P45984-3 ENST00000343111;ENST00000347470;ENST00000393360;ENST00000393362 4 0.77173 1.352 0.65313 0.99292 0.94774 0.85012 WW cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;protein binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding;transcription regulator activity biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 3 3 3 16.2 16.2 16.2 30.472 2.6052E-10 98486000 51295000 47191000 1858 IPI:IPI00024698.1;IPI:IPI00654698.1;IPI:IPI00386483.1;IPI:IPI00607824.2;IPI:IPI00030216.3;IPI:IPI00644888.1;IPI:IPI00386509.1;IPI:IPI00607789.1;IPI:IPI00654565.1 Polyglutamine-binding protein 1;Polyglutamine tract-binding protein 1;PQBP-1;38 kDa nuclear protein containing a WW domain;Npw38 PQBP1;NPW38;JM26 O60828-1;O60828;O60828-2;O60828-4;O60828-5 ENST00000218224;ENST00000376548;ENST00000376563;ENST00000376564;ENST00000376566;ENST00000396763;ENST00000396764 9 0.98989 1.6801 0.97466 1.2624 1.0851 1.1837 PH;START cell part;cytoplasmic part;endoplasmic reticulum;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle binding;catalytic activity;kinase activity;phosphotransferase activity, alcohol group as acceptor;protein binding;protein kinase activity;transferase activity;transferase activity, transferring phosphorus-containing groups cellular process;immune response;immune system process;lipid transport;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein modification process;transport 5 5 5 11.4 11.4 11.4 70.834 3.0266E-15 99429000 49086000 50344000 1859 IPI:IPI00024701.3;IPI:IPI00182914.2 Collagen type IV alpha-3-binding protein;Ceramide transfer protein;Goodpasture antigen-binding protein;StAR-related lipid transfer protein 11;START domain-containing protein 11 COL4A3BP;CERT;STARD11 Q9Y5P4-1;Q9Y5P4;Q9Y5P4-2 ENST00000261415;ENST00000357457;ENST00000380493;ENST00000380494;ENST00000405807 2 1.0275 1.5211 0.79307 1.33 1.096 1.0847 PDZ cell cortex;cell fraction;clathrin-coated vesicle;coated vesicle;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;cytosol;insoluble fraction;membrane;membrane fraction;organelle membrane;soluble fraction;synaptic vesicle;vesicle;vesicle membrane actin binding;binding;cytoskeletal protein binding;identical protein binding;myosin binding;protein binding;protein dimerization activity;protein homodimerization activity;receptor binding cell communication;cell motion;cell surface receptor linked signal transduction;generation of a signal involved in cell-cell signaling;intracellular protein transport;protein targeting;signal transduction;transport 4 4 4 16.2 16.2 16.2 36.049 1.3131E-14 61267000 31716000 29551000 1860 IPI:IPI00024705.1;IPI:IPI00021537.5;IPI:IPI00216130.8 PDZ domain-containing protein GIPC1;RGS19-interacting protein 1;GAIP C-terminus-interacting protein;RGS-GAIP-interacting protein;Tax interaction protein 2 GIPC1;C19orf3;GIPC;RGS19IP1 O14908 ENST00000345425;ENST00000393033 3 0.38097 1.0479 0.35506 0.51593 0.677 0.47497 Pkinase;ubiquitin cell part;cytoplasmic part;cytosol;intracellular part ATP binding;binding;catalytic activity;IkappaB kinase activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;regulation of biosynthetic process;regulation of gene expression Acute myeloid leukemia;Adipocytokine signaling pathway;Apoptosis;B cell receptor signaling pathway;Chemokine signaling pathway;Chronic myeloid leukemia;Epithelial cell signaling in Helicobacter pylori infection;Insulin signaling pathway;MAPK signaling pathway;Pancreatic cancer;Pathways in cancer;Prostate cancer;Small cell lung cancer;T cell receptor signaling pathway;Toll-like receptor signaling pathway;Type II diabetes mellitus 6 6 6 7.8 7.8 7.8 86.563 5.0955E-16 23246000 13476000 9770900 1861 IPI:IPI00024709.1 Inhibitor of nuclear factor kappa-B kinase subunit beta;I-kappa-B kinase 2;Nuclear factor NF-kappa-B inhibitor kinase beta IKBKB;IKKB O14920 ENST00000342222 K07209 1 0.68536 1.2706 0.68584 0.8666 0.82651 0.88454 Hat1_N cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle acetyltransferase activity;acyltransferase activity;binding;catalytic activity;histone acetyltransferase activity;lysine N-acetyltransferase activity;N-acetyltransferase activity;N-acyltransferase activity;protein binding;transferase activity chromatin organization;chromatin silencing;chromatin silencing at telomere;DNA packaging;internal protein amino acid acetylation;organelle organization;protein amino acid acetylation;protein modification process;regulation of transcription, DNA-dependent 18 18 18 54.2 54.2 54.2 49.512 4.3976E-304 1265100000 685380000 579710000 1862 IPI:IPI00024719.1 Histone acetyltransferase type B catalytic subunit HAT1 O14929 ENST00000264108 1 NaN NaN 0.9886 NaN NaN 1.2999 Ras cell part;membrane;plasma membrane binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity cell communication;cellular process;establishment of protein localization;intracellular signaling cascade;protein transport;regulation of biological process;signal transduction;small GTPase mediated signal transduction;transport 2 2 2 13.3 13.3 13.3 23.155 4.0146E-10 4109500 2142000 1967500 1865 IPI:IPI00024775.1 Ras-related protein Rab-7L1;Rab-7-like protein 1 RAB7L1 O14966 ENST00000235932;ENST00000367139;ENST00000367140 K07916 1 1.312 1.2881 1.336 1.7284 0.92122 1.7369 AMP-binding endoplasmic reticulum membrane;integral to membrane;intrinsic to membrane;membrane;membrane-bounded organelle;membrane-enclosed lumen;microbody;microbody lumen;microbody membrane;organelle;organelle membrane;peroxisomal matrix;peroxisomal membrane ATP binding;binding;catalytic activity;fatty-acid ligase activity;ligase activity;ligase activity, forming carbon-sulfur bonds;long-chain-fatty-acid-CoA ligase activity;nucleoside binding;nucleotide binding;purine nucleoside binding carboxylic acid metabolic process;cellular process;fatty acid metabolic process;lipid metabolic process;metabolic process;monocarboxylic acid metabolic process;organic acid metabolic process;very-long-chain fatty acid metabolic process PPAR signaling pathway 4 4 4 6 6 6 70.311 3.5524E-07 807830000 402710000 405120000 1866 IPI:IPI00024787.1 Very long-chain acyl-CoA synthetase;Very long-chain-fatty-acid-CoA ligase;THCA-CoA ligase;Fatty-acid-coenzyme A ligase, very long-chain 1;Long-chain-fatty-acid--CoA ligase;Fatty acid transport protein 2;Solute carrier family 27 member 2 SLC27A2;ACSVL1;FACVL1;FATP2;VLACS O14975 ENST00000267842 K08746 1 0.63575 1.1578 0.56133 0.83477 0.76252 0.74398 HEAT;Helicase_C;SNF2_N cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;DNA binding;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity;transcription factor activity negative regulation of biosynthetic process;negative regulation of metabolic process;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process 15 15 15 10.4 10.4 10.4 206.89 5.5133E-192 149350000 84167000 65181000 1867 IPI:IPI00024802.1 TATA-binding protein-associated factor 172;ATP-dependent helicase BTAF1;TBP-associated factor 172;TAF(II)170;B-TFIID transcription factor-associated 170 kDa subunit BTAF1;TAF172 O14981 ENST00000265990 1 0.85324 1.7403 NaN 1.1458 1.0831 NaN DUF800 cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial membrane;mitochondrial outer membrane;mitochondrial part;organelle membrane;organelle outer membrane;organelle part;outer membrane 4 4 4 14.6 14.6 14.6 38.464 4.6057E-15 45064000 25462000 19601000 1868 IPI:IPI00026448.2;IPI:IPI00024816.3;IPI:IPI00555826.1;IPI:IPI00031927.1;IPI:IPI00024627.1 Mitochondrial fission factor MFF;C2orf33;AD030;AD033;GL004 Q9GZY8-1;Q9GZY8;Q9GZY8-2;Q9GZY8-3;Q9GZY8-5;Q9GZY8-4 ENST00000304593;ENST00000337110;ENST00000349901;ENST00000353339;ENST00000354503;ENST00000392058;ENST00000392059 5 0.84667 1.6441 0.82452 1.0744 1.1041 1.0762 Mov34 cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;proteasome complex;protein complex binding;catalytic activity;cation binding;hydrolase activity;hydrolase activity, acting on ester bonds;ion binding;metallopeptidase activity;peptidase activity;protein binding;thiolester hydrolase activity;ubiquitin thiolesterase activity;zinc ion binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;proteasomal protein catabolic process;protein deubiquitination;protein modification process;proteolysis;ubiquitin-dependent protein catabolic process Proteasome 11 11 11 52.6 52.6 52.6 34.577 1.6314E-230 1737000000 894030000 842990000 1869 IPI:IPI00024821.1 26S proteasome non-ATPase regulatory subunit 14;26S proteasome regulatory subunit rpn11;26S proteasome-associated PAD1 homolog 1 PSMD14;POH1 O00487 ENST00000409682 K03030 1 0.76703 1.7019 0.80726 1.0639 1.1166 1.0653 CBF_beta cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;protein binding;RNA polymerase II transcription factor activity;transcription coactivator activity;transcription cofactor activity;transcription factor activity;transcription factor binding biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent 10 10 2 44.4 44.4 10.7 21.991 6.5944E-303 357060000 189740000 167310000 1870 IPI:IPI00024871.1 Core-binding factor subunit beta;Polyomavirus enhancer-binding protein 2 beta subunit;SL3-3 enhancer factor 1 subunit beta;SL3/AKV core-binding factor beta subunit CBFB Q13951-2;Q13951 ENST00000290858 1 0.29689 0.62198 NaN 0.37194 0.42924 NaN BTB;Kelch_1 binding;DNA binding;nucleic acid binding;protein binding;transcription factor activity;transcription regulator activity anatomical structure morphogenesis;developmental process 2 2 2 2.5 2.5 2.5 94.718 8.7655E-05 1018300 751820 266520 1871 IPI:IPI00024893.5 Leucine-zipper-like transcriptional regulator 1 LZTR1;TCFL2 Q8N653 ENST00000215739;ENST00000389355 1 0.77885 1.6113 0.73079 1.0126 1.0303 0.99054 ERp29;ERp29_N cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;endoplasmic reticulum;endoplasmic reticulum lumen;intracellular organelle;melanosome;membrane-bounded organelle;membrane-bounded vesicle;membrane-enclosed lumen;organelle;vesicle catalytic activity;intramolecular oxidoreductase activity;intramolecular oxidoreductase activity, interconverting keto- and enol-groups;intramolecular oxidoreductase activity, transposing S-S bonds;isomerase activity;protein disulfide isomerase activity cellular biopolymer metabolic process;cellular process;intracellular protein transport;macromolecule metabolic process;metabolic process;protein folding;protein metabolic process;protein secretion;protein transport;secretion by cell;transport 12 12 12 45.2 45.2 45.2 28.993 9.6468E-165 637400000 345010000 292390000 1872 IPI:IPI00024911.1 Endoplasmic reticulum protein ERp29;ERp31;ERp28 ERP29;C12orf8;ERP28 P30040 ENST00000261735 1 0.65571 1.9539 0.78248 0.93865 1.1759 1.0735 DJ-1_PfpI cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle 6 6 6 32.8 32.8 32.8 28.17 1.0613E-71 119890000 67924000 51962000 1873 IPI:IPI00024913.2;IPI:IPI00218482.2 ES1 protein homolog, mitochondrial;Protein KNP-I;Protein GT335 C21orf33;HES1;KNPI P30042-1;P30042;P30042-2 ENST00000291577;ENST00000348499 2 0.82639 1.645 0.84767 1.0856 1.0857 1.0921 1-cysPrx_C;AhpC-TSA cell part;cytoplasmic part;early endosome;endosome;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle alkyl hydroperoxide reductase activity;antioxidant activity;binding;catalytic activity;cysteine-type endopeptidase inhibitor activity;endopeptidase inhibitor activity;enzyme inhibitor activity;peroxidase activity;protein binding;protein C-terminus binding cellular ion homeostasis;mitochondrion organization;organelle organization;oxygen and reactive oxygen species metabolic process;response to molecule of bacterial origin;response to oxidative stress;response to reactive oxygen species;response to stress 11 11 11 41.4 41.4 41.4 27.692 0 1548700000 814160000 734590000 1874 IPI:IPI00024919.3 Thioredoxin-dependent peroxide reductase, mitochondrial;Peroxiredoxin-3;PRX III;Antioxidant protein 1;Protein MER5 homolog;HBC189 PRDX3;AOP1 P30048 ENST00000298510 K03386 1 0.67703 1.4666 0.73299 0.90508 0.9906 0.93457 ATP-synt_DE;ATP-synt_DE_N intracellular part;macromolecular complex;membrane part;mitochondrial matrix;mitochondrial proton-transporting ATP synthase complex, catalytic core F(1);organelle part;protein complex;proton-transporting two-sector ATPase complex, catalytic domain catalytic activity;cation transmembrane transporter activity;hydrogen ion transmembrane transporter activity;ion transmembrane transporter activity;monovalent inorganic cation transmembrane transporter activity;transporter activity ATP catabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide catabolic process;purine nucleotide metabolic process Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 3 3 3 17.3 17.3 17.3 17.49 4.7061E-77 660750000 369600000 291150000 1875 IPI:IPI00024920.1 ATP synthase subunit delta, mitochondrial;F-ATPase delta subunit ATP5D P30049 ENST00000215375;ENST00000395633 K02134 1 0.69721 1.3698 0.71942 0.90837 0.9135 0.91372 Ribosomal_L11;Ribosomal_L11_N cell part;cytoplasmic part;cytosol;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome binding;nucleic acid binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 9 9 9 63 63 63 17.818 0 5342200000 3022200000 2320000000 1876 IPI:IPI00024933.3;IPI:IPI00816063.1 60S ribosomal protein L12 RPL12 P30050-1;P30050;P30050-2 ENST00000361436 K02870 2 0.8454 1.6112 0.77262 1.1329 1.0349 1.0563 B12-binding;MM_CoA_mutase cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part binding;catalytic activity;cation binding;cobalamin binding;intramolecular transferase activity;ion binding;isomerase activity;metal ion binding;methylmalonyl-CoA mutase activity;tetrapyrrole binding;transition metal ion binding;vitamin binding metabolic process Propanoate metabolism;Valine, leucine and isoleucine degradation 10 10 10 18.4 18.4 18.4 83.119 1.332E-91 184960000 105420000 79539000 1877 IPI:IPI00024934.4 Methylmalonyl-CoA mutase, mitochondrial;Methylmalonyl-CoA isomerase MUT P22033 ENST00000274813 K01847 1 0.77318 1.5919 0.78112 1.0475 1.0068 1.0654 Oxysterol_BP;PH cell part;cytoplasmic part;Golgi apparatus part;Golgi membrane;intracellular organelle part;intracellular part;membrane;organelle membrane;organelle part binding;lipid binding;oxysterol binding;steroid binding;sterol binding biosynthetic process;cellular biosynthetic process;cellular lipid metabolic process;cellular metabolic process;cellular process;lipid metabolic process;lipid transport;metabolic process;primary metabolic process;steroid metabolic process;transport 18 18 18 29.4 29.4 29.4 89.42 1.4588E-204 390580000 209050000 181530000 1878 IPI:IPI00024971.1;IPI:IPI00440762.2;IPI:IPI00746936.1 Oxysterol-binding protein 1 OSBP;OSBP1 P22059-1;P22059 ENST00000263847 3 0.60163 1.1827 0.62167 0.81909 0.77093 0.82151 Kinesin centrosome;intracellular organelle;kinesin complex;macromolecular complex;microtubule;microtubule associated complex;microtubule organizing center;non-membrane-bounded organelle;organelle;plus-end kinesin complex;spindle ATP binding;binding;catalytic activity;DNA binding;hydrolase activity;microtubule motor activity;motor activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity cell cycle phase;cell cycle process;cell proliferation;cellular component organization;cellular process;microtubule-based movement;microtubule-based process;mitosis;nuclear division;organelle fission;organelle organization 14 14 14 12.9 12.9 12.9 160.16 1.0681E-294 83066000 44599000 38467000 1879 IPI:IPI00024975.2;IPI:IPI00889513.1;IPI:IPI00479255.3;IPI:IPI00794555.1;IPI:IPI00016870.1 Kinesin-like protein KIF15;Kinesin-like protein 2;Kinesin-like protein 7;Serologically defined breast cancer antigen NY-BR-62 KIF15;KLP2;KNSL7 Q9NS87-1;Q9NS87;Q9NS87-2;Q9NS87-4 ENST00000326047;ENST00000396031 K10400 5 0.79357 1.4622 0.87308 0.98169 1.0299 1.0249 IMS-faced cell fraction;insoluble fraction;integral to membrane;integral to membrane of membrane fraction;intrinsic to membrane;macromolecular complex;membrane fraction;mitochondrial outer membrane translocase complex;organelle part;protein complex binding;protein binding;protein transmembrane transporter activity;protein transporter activity;receptor activity;signal transducer activity;substrate-specific transmembrane transporter activity;transmembrane transporter activity;transporter activity anatomical structure formation;cellular component organization;cellular process;intracellular protein transport;mitochondrial transport;protein complex assembly;protein targeting;protein targeting to mitochondrion;protein transport;transport 3 3 3 33.8 33.8 33.8 15.521 2.3481E-52 303140000 155770000 147370000 1880 IPI:IPI00024976.5 Mitochondrial import receptor subunit TOM22 homolog;Translocase of outer membrane 22 kDa subunit homolog;1C9-2 TOMM22;TOM22 Q9NS69 ENST00000216034 1 1.0419 2.3589 1.1357 1.388 1.4957 1.5137 Aldedh cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle acyl-CoA binding;binding;catalytic activity;fatty acid binding;lipid binding;methylmalonate-semialdehyde dehydrogenase (acylating) activity;oxidoreductase activity cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;pyrimidine base metabolic process;valine metabolic process Inositol phosphate metabolism;Propanoate metabolism;Valine, leucine and isoleucine degradation 10 10 10 19.8 19.8 19.8 57.839 1.6332E-153 118630000 63218000 55417000 1881 IPI:IPI00024990.6 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial;Aldehyde dehydrogenase family 6 member A1 ALDH6A1;MMSDH Q02252 ENST00000350259 K00140 1 0.81295 1.7611 0.83902 1.0705 1.1479 1.0575 ECH cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part binding;carbon-oxygen lyase activity;catalytic activity;enoyl-CoA hydratase activity;hydro-lyase activity;lyase activity;protein binding catabolic process;cellular process;fatty acid beta-oxidation;fatty acid catabolic process;fatty acid metabolic process;lipid catabolic process;lipid metabolic process;metabolic process;organic acid catabolic process;organic acid metabolic process Benzoate degradation via CoA ligation;beta-Alanine metabolism;Butanoate metabolism;Caprolactam degradation;Fatty acid elongation in mitochondria;Fatty acid metabolism;Limonene and pinene degradation;Lysine degradation;Propanoate metabolism;Tryptophan metabolism;Valine, leucine and isoleucine degradation 11 11 11 45.9 45.9 45.9 31.387 0 517130000 275190000 241950000 1882 IPI:IPI00024993.4 Enoyl-CoA hydratase, mitochondrial;Short chain enoyl-CoA hydratase;Enoyl-CoA hydratase 1 ECHS1 P30084 ENST00000368547 K07511 1 0.88134 1.7656 0.89242 1.1323 1.1855 1.1309 Proteasome cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;proteasome core complex;protein complex binding;catalytic activity;endopeptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides;protein binding;threonine-type endopeptidase activity;threonine-type peptidase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Proteasome 10 10 10 43.6 43.6 43.6 26.489 0 2397100000 1240100000 1156900000 1883 IPI:IPI00025019.3 Proteasome subunit beta type-1;Proteasome component C5;Macropain subunit C5;Multicatalytic endopeptidase complex subunit C5;Proteasome gamma chain PSMB1;PSC5 P20618 ENST00000262193 K02732 1 0.7308 1.4571 0.71408 0.98666 0.93342 0.93737 Fibrillarin cell part;intracellular part;macromolecular complex;ribonucleoprotein complex binding;catalytic activity;methyltransferase activity;nucleic acid binding;protein binding;RNA binding;transferase activity;transferase activity, transferring one-carbon groups cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 19 19 19 51.7 51.7 51.7 33.784 7.1023E-298 3972800000 2143500000 1829300000 1884 IPI:IPI00025039.1;IPI:IPI00235647.8 rRNA 2'-O-methyltransferase fibrillarin;34 kDa nucleolar scleroderma antigen FBL;FIB1;FLRN P22087 ENST00000221801 2 0.99947 2.3367 1.0033 1.3216 1.6665 1.252 Man-6-P_recep cell surface;integral to membrane;integral to plasma membrane;intracellular part;intrinsic to membrane;intrinsic to plasma membrane;lysosomal membrane;membrane;membrane part;organelle membrane;organelle part;vacuolar membrane;vacuolar part binding;carbohydrate transmembrane transporter activity;mannose binding;monosaccharide transmembrane transporter activity;protein binding;receptor activity;signal transducer activity;sugar binding;transmembrane receptor activity;transporter activity carbohydrate transport;cellular process;endocytosis;endosome to lysosome transport;hexose transport;lysosomal transport;mannose transport;membrane invagination;monosaccharide transport;receptor-mediated endocytosis;transport;vacuolar transport 4 4 4 15.5 15.5 15.5 30.993 1.7943E-107 283120000 144170000 138960000 1885 IPI:IPI00025049.1 Cation-dependent mannose-6-phosphate receptor;46 kDa mannose 6-phosphate receptor;MPR 46 M6PR;MPR46;MPRD P20645 ENST00000000412 K10089 1 0.68832 1.6918 0.33491 0.95392 1.0313 0.4578 tRNA-synt_1b cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-oxygen bonds;nucleoside binding;nucleotide binding;purine nucleoside binding;tryptophan-tRNA ligase activity cellular amino acid and derivative metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;tRNA aminoacylation for protein translation;tRNA metabolic process;tryptophanyl-tRNA aminoacylation Aminoacyl-tRNA biosynthesis;Tryptophan metabolism 4 4 4 15.6 15.6 15.6 40.146 1.4818E-24 5434300 4140200 1294100 1886 IPI:IPI00025050.1 Tryptophanyl-tRNA synthetase, mitochondrial;Tryptophan--tRNA ligase;(Mt)TrpRS WARS2 Q9UGM6 ENST00000235521 K01867 1 0.75082 1.0273 0.79435 0.9123 0.72712 1.0232 Mog1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle enzyme regulator activity;GTPase regulator activity;guanyl-nucleotide exchange factor activity;nucleoside-triphosphatase regulator activity establishment of localization;establishment of protein localization;protein transport;transport 4 4 4 27.4 27.4 27.4 20.448 1.5061E-78 138750000 72348000 66401000 1888 IPI:IPI00025081.2;IPI:IPI00789985.1;IPI:IPI00790572.1;IPI:IPI00794484.1 Ran guanine nucleotide release factor;Ran-binding protein MOG1 RANGRF;MOG1;RANGNRF;HSPC165;HSPC236;MDS5 Q9HD47-1;Q9HD47;Q9HD47-2;Q9HD47-3;Q9HD47-4 ENST00000226105;ENST00000407006 4 0.6409 1.4574 0.71023 0.89353 0.95568 0.93539 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;nucleus;organelle;plasma membrane binding;calcium ion binding;calcium-dependent cysteine-type endopeptidase activity;catalytic activity;cysteine-type endopeptidase activity;cysteine-type peptidase activity;endopeptidase activity;hydrolase activity;peptidase activity;protein binding biological regulation;positive regulation of biological process;positive regulation of cell proliferation;positive regulation of cellular process;regulation of biological process;regulation of cell proliferation;regulation of cellular process 10 10 10 34.7 34.7 34.7 28.315 1.1723E-155 443850000 235390000 208460000 1889 IPI:IPI00025084.3;IPI:IPI00306986.2 Calpain small subunit 1;Calcium-dependent protease small subunit 1;Calcium-dependent protease small subunit;Calpain regulatory subunit;Calcium-activated neutral proteinase small subunit CAPNS1;CAPN4;CAPNS P04632 ENST00000246533 K08583 2 0.74827 1.5455 0.80213 0.99606 1.008 0.97561 COX5A cell part;cytoplasmic part;intracellular organelle part;intracellular part;membrane;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part binding;catalytic activity;cation transmembrane transporter activity;cytochrome-c oxidase activity;electron carrier activity;heme-copper terminal oxidase activity;ion transmembrane transporter activity;iron ion binding;transporter activity 7 7 7 52.7 52.7 52.7 16.762 8.4749E-97 1895300000 996700000 898570000 1890 IPI:IPI00025086.4 Cytochrome c oxidase subunit 5A, mitochondrial;Cytochrome c oxidase polypeptide Va COX5A P20674 ENST00000322347 1 0.74662 1.3315 0.74483 0.91675 0.92201 0.95498 Ribosomal_S17 cell part;cytoplasmic part;cytosolic part;cytosolic small ribosomal subunit;intracellular organelle part;intracellular part;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit binding;nucleic acid binding;protein binding;RNA binding;rRNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 19 19 19 69 69 69 18.431 5.7127E-108 6041500000 3157700000 2883800000 1891 IPI:IPI00025091.3 40S ribosomal protein S11 RPS11 P62280 ENST00000270625 K02949 1 0.86537 1.4622 0.83877 1.0906 0.97792 1.0972 E1_dh cytoplasmic part;intracellular organelle part;intracellular part;macromolecular complex;mitochondrial alpha-ketoglutarate dehydrogenase complex;mitochondrial part;mitochondrial tricarboxylic acid cycle enzyme complex;organelle part;protein complex 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity;alpha-ketoacid dehydrogenase activity;binding;catalytic activity;oxidoreductase activity catabolic process;cellular amino acid and derivative metabolic process;cellular amino acid catabolic process;cellular amino acid metabolic process;metabolic process;nitrogen compound metabolic process;organic acid metabolic process Valine, leucine and isoleucine degradation 6 6 6 20.9 20.9 20.9 50.47 1.3869E-72 172670000 89094000 83574000 1892 IPI:IPI00025100.1 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial;Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain BCKDHA P12694 ENST00000269980 K00166 1 0.79938 1.2987 0.74666 1.0011 0.92935 0.94163 TPR_1;U-box cell part;cytoplasm;intracellular part;macromolecular complex;protein complex;ubiquitin conjugating enzyme complex;ubiquitin ligase complex binding;enzyme binding;heat shock protein binding;Hsp70 protein binding;Hsp90 protein binding;protein binding;protein binding, bridging;protein domain specific binding;SMAD binding;TPR domain binding catabolic process;macromolecule catabolic process;metabolic process;protein folding;protein modification process;protein polyubiquitination;proteolysis;regulation of biosynthetic process;ubiquitin-dependent protein catabolic process Ubiquitin mediated proteolysis 8 8 8 26.1 26.1 26.1 34.856 1.7515E-117 152780000 77887000 74894000 1893 IPI:IPI00025156.4;IPI:IPI00645380.1 STIP1 homology and U box-containing protein 1;Carboxy terminus of Hsp70-interacting protein;E3 ubiquitin-protein ligase CHIP;CLL-associated antigen KW-8;Antigen NY-CO-7 STUB1;CHIP;PP1131 Q9UNE7-1;Q9UNE7;Q9UNE7-2 ENST00000219548 K09561 2 0.75927 1.4246 NaN 0.95815 1.0169 NaN STAG cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding cell cycle phase;cell cycle process;cell division;cellular component organization;cellular process;chromosome segregation;mitosis;nuclear division;organelle fission;organelle organization Cell cycle - yeast 4 1 1 2.8 0.7 0.7 144.43 5.1332E-07 600400 313250 287150 1894 IPI:IPI00025158.2 Cohesin subunit SA-1;Stromal antigen 1;SCC3 homolog 1 STAG1;SA1 Q8WVM7 ENST00000383202 K06671 1 2.067 1.7546 0.88056 2.7591 1.0933 1.1735 HEAT binding;molecular transducer activity;protein binding;receptor activity;signal transducer activity biological regulation;cell communication;cellular process;interspecies interaction between organisms;multi-organism process;regulation of biological process;regulation of cellular process;signal transduction 5 5 5 7 7 7 87.972 1.0261E-44 26050000 12135000 13914000 1895 IPI:IPI00025160.2 Protein VAC14 homolog;Tax1-binding protein 2 VAC14;TAX1BP2;TRX Q08AM6 ENST00000261776 1 0.9175 1.5903 0.95873 1.3129 1.0537 1.2461 Pro_isomerase catalytic activity;cis-trans isomerase activity;isomerase activity;peptidyl-prolyl cis-trans isomerase activity biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 5 5 5 20.1 20.1 20.1 53.846 6.9295E-84 116560000 59454000 57102000 1896 IPI:IPI00025174.2;IPI:IPI00879475.1 Peptidyl-prolyl cis-trans isomerase SDCCAG10;Serologically defined colon cancer antigen 10;Antigen NY-CO-10 SDCCAG10;UNQ438/PRO871 Q6UX04-1;Q6UX04;Q6UX04-2 ENST00000381070 K01802 2 0.82437 1.6459 NaN 1.1441 1.0207 NaN SMN Cajal body;cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;catalytic activity;nucleic acid binding;protein binding;RNA binding;RNA splicing factor activity, transesterification mechanism anatomical structure formation;apoptosis;cell death;cellular process;induction of apoptosis;induction of programmed cell death;positive regulation of cell death;programmed cell death;regulation of cell death;spliceosome assembly 3 3 3 18.1 18.1 18.1 26.711 8.0904E-59 62612000 35595000 27017000 1897 IPI:IPI00025176.1 Survival of motor neuron-related-splicing factor 30;SMN-related protein;30 kDa splicing factor SMNrp;Survival motor neuron domain-containing protein 1 SMNDC1;SMNR;SPF30 O75940 ENST00000369592;ENST00000369603 1 0.76533 1.4547 0.74736 1.0287 0.95224 0.98136 BCAS2 intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;ribonucleoprotein complex;spliceosomal complex binding;catalytic activity;protein binding;RNA splicing factor activity, transesterification mechanism cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 9 9 9 51.1 51.1 51.1 26.131 1.0003E-113 619420000 324790000 294630000 1898 IPI:IPI00025178.3 Pre-mRNA-splicing factor SPF27;Spliceosome-associated protein SPF 27;Breast carcinoma-amplified sequence 2;DNA amplified in mammary carcinoma 1 protein BCAS2;DAM1 O75934 ENST00000369541 1 0.74301 1.6499 0.61081 0.94713 1.0451 0.81811 Drf_FH3;Drf_GBD;FH2 cell part;cytoplasm;intracellular part actin binding;binding;cytoskeletal protein binding;enzyme binding;GTPase binding;protein binding;Ras GTPase binding;Rho GTPase binding;small GTPase binding actin cytoskeleton organization;actin filament-based process;cellular component organization;cellular process;cytoskeleton organization;organelle organization 15 15 14 17.7 17.7 16.8 122.41 1.2341E-109 230890000 124760000 106130000 1899 IPI:IPI00025202.6;IPI:IPI00163516.4 Formin-like protein 1;Leukocyte formin;CLL-associated antigen KW-13 FMNL1;C17orf1;C17orf1B;FMNL O95466-2;O95466;O95466-1 ENST00000328118;ENST00000331495 2 0.77359 1.6331 0.7545 1.0225 1.0933 1.062 Complex1_49kDa cytoplasmic part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;mitochondrial membrane part;mitochondrial part;mitochondrial respiratory chain complex I;NADH dehydrogenase complex;organelle part;protein complex binding;catalytic activity;electron carrier activity;iron ion binding;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH cellular process;electron transport chain;generation of precursor metabolites and energy;metabolic process;mitochondrial electron transport, NADH to ubiquinone;respiratory electron transport chain;response to oxidative stress;response to stress;transport Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 17 17 17 39.7 39.7 39.7 52.545 2.5022E-80 467550000 264500000 203050000 1900 IPI:IPI00025239.2 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial;NADH-ubiquinone oxidoreductase 49 kDa subunit;Complex I-49kD NDUFS2 O75306 ENST00000367993;ENST00000392179 K03935 1 0.80477 1.6039 0.91963 1.0215 1.0731 1.1549 zf-ZPR1 cell part;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding biological regulation;cell communication;cell proliferation;cellular process;regulation of biological process;regulation of cellular process;signal transduction 10 10 10 25.7 25.7 25.7 50.925 1.0959E-190 295620000 111470000 184150000 1901 IPI:IPI00025244.1 Zinc finger protein ZPR1;Zinc finger protein 259 ZNF259;ZPR1 O75312 ENST00000227322 K06874 1 0.99256 2.0154 0.94656 1.2903 1.307 1.272 Thioredoxin cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;endoplasmic reticulum;endoplasmic reticulum lumen;intracellular organelle;melanosome;membrane-bounded organelle;membrane-bounded vesicle;membrane-enclosed lumen;organelle;vesicle binding;catalytic activity;cysteine-type endopeptidase activity;endopeptidase activity;peptidase activity;phospholipase activity;phospholipase C activity;phosphoric diester hydrolase activity;protein binding;protein disulfide isomerase activity cell communication;cellular homeostasis;cellular process;intracellular protein transport;nucleocytoplasmic transport;protein import;protein import into nucleus;protein retention in ER lumen;protein targeting;protein transport;signal transduction;transport Antigen processing and presentation 34 34 34 61.6 61.6 61.6 56.782 0 10876000000 5645000000 5230700000 1902 IPI:IPI00025252.1 Protein disulfide-isomerase A3;Disulfide isomerase ER-60;ERp60;58 kDa microsomal protein;p58;ERp57;58 kDa glucose-regulated protein PDIA3;ERP57;ERP60;GRP58 P30101 ENST00000300289 K08056 1 0.63458 1.1949 0.63633 0.82522 0.78868 0.80129 AIRS;AIRS_C;Formyl_trans_N;GARS_A;GARS_C;GARS_N cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;nucleus;organelle catalytic activity;glycine hydroxymethyltransferase activity;nucleoside binding;nucleotide binding;phosphoribosylamine-glycine ligase activity;phosphoribosylformylglycinamidine cyclo-ligase activity;purine nucleoside binding 'de novo' IMP biosynthetic process;IMP biosynthetic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;purine base metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process One carbon pool by folate;Purine metabolism 42 42 42 51 51 51 107.77 0 3854100000 2165900000 1688200000 1903 IPI:IPI00025273.1;IPI:IPI00218408.1 Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Glycinamide ribonucleotide synthetase;Phosphoribosylglycinamide synthetase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosyl-aminoimidazole synthetase;AIR synthase;Phosphoribosylglycinamide formyltransferase;5'-phosphoribosylglycinamide transformylase;GAR transformylase GART;PGFT;PRGS P22102-1;P22102;P22102-2 ENST00000361093;ENST00000381815;ENST00000381831;ENST00000381839 K11787 2 0.91006 1.7936 0.93906 1.183 1.2119 1.2359 efhand cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;intracellular organelle part;intracellular part;membrane;membrane part;nuclear membrane;nuclear part;organelle membrane;organelle part binding;calcium ion binding;calcium-dependent protein binding;cation binding;ion binding;metal ion binding;protein binding apoptosis;cell death;cellular process;induction of apoptosis;induction of apoptosis by extracellular signals;positive regulation of cell death;programmed cell death;regulation of cell death;response to inorganic substance;response to metal ion 10 10 10 54.5 54.5 54.5 21.868 1.8017E-67 849390000 435190000 414210000 1904 IPI:IPI00025277.5 Programmed cell death protein 6;Apoptosis-linked gene 2 protein;Probable calcium-binding protein ALG-2 PDCD6;ALG2 O75340 ENST00000264933;ENST00000316418 1 1.0443 1.7115 1.0263 1.3112 1.1547 1.3759 V-ATPase_G cation transport;establishment of localization;hydrogen transport;ion transport;monovalent inorganic cation transport;proton transport;transport Epithelial cell signaling in Helicobacter pylori infection;Oxidative phosphorylation;Vibrio cholerae infection 6 6 6 55.9 55.9 55.9 13.757 2.8065E-80 395420000 194640000 200780000 1905 IPI:IPI00025285.3;IPI:IPI00032147.1 V-type proton ATPase subunit G 1;Vacuolar proton pump subunit G 1;V-ATPase 13 kDa subunit 1;Vacuolar proton pump subunit M16 ATP6V1G1;ATP6G;ATP6G1;ATP6J O75348 ENST00000374050 K02152 2 0.78532 1.7516 0.81286 1.0429 1.1289 1.1256 PQ-loop cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part binding;protein binding biosynthetic process;carbohydrate metabolic process;dolichol-linked oligosaccharide biosynthetic process;metabolic process;protein amino acid glycosylation;protein amino acid N-linked glycosylation;protein folding;protein modification process 5 5 5 16.2 16.2 16.2 26.638 3.3988E-75 135730000 69751000 65980000 1906 IPI:IPI00025292.2 Mannose-P-dolichol utilization defect 1 protein;Suppressor of Lec15 and Lec35 glycosylation mutation homolog MPDU1 O75352 ENST00000250124;ENST00000359822 K09660 1 NaN 1.6949 0.61836 NaN 1.0461 0.92295 zf-C2H2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;transcription factor activity;transcription regulator activity;transition metal ion binding;zinc ion binding biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription;transcription, DNA-dependent 3 3 2 3.7 3.7 3 115.27 8.403E-09 658180 367240 290940 1907 IPI:IPI00025310.1;IPI:IPI00006046.4 Zinc finger protein 217 ZNF217;ZABC1 O75362 ENST00000302342;ENST00000371471 2 0.89845 1.8594 0.98102 1.2095 1.1582 1.2757 SH3BGR cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;molecular adaptor activity;molecular transducer activity;protein binding;protein binding, bridging;protein domain specific binding;SH3 domain binding;SH3/SH2 adaptor activity;signal transducer activity 6 6 6 60.5 60.5 60.5 12.774 1.2432E-250 389740000 209160000 180580000 1908 IPI:IPI00025318.1 SH3 domain-binding glutamic acid-rich-like protein SH3BGRL O75368 ENST00000373212 1 0.68612 1.2769 0.789 0.93459 0.82529 1.0764 Ribosomal_L19e cell part;cytoplasmic part;cytosolic large ribosomal subunit;cytosolic part;intracellular organelle part;intracellular part;large ribosomal subunit;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit binding;nucleic acid binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 7 7 7 29.6 29.6 29.6 23.466 1.2073E-173 1240400000 621310000 619060000 1909 IPI:IPI00025329.1 60S ribosomal protein L19 RPL19 P84098 ENST00000225430 K02885 1 0.73902 1.4637 0.78245 1.0187 0.93982 1.054 DUF689 cell part;cytoplasm;intracellular part anti-apoptosis;apoptosis;cell death;cellular process;death;negative regulation of apoptosis;negative regulation of programmed cell death;programmed cell death;regulation of apoptosis;regulation of cell death;regulation of programmed cell death 10 10 10 40.7 40.7 40.7 33.582 8.188E-128 448370000 230720000 217650000 1910 IPI:IPI00387130.1;IPI:IPI00025333.4;IPI:IPI00513770.1 Anamorsin;Cytokine-induced apoptosis inhibitor 1 CIAPIN1;CUA001;PRO0915 Q6FI81-1;Q6FI81;Q6FI81-3;Q6FI81-2 ENST00000356811;ENST00000394391 3 0.71848 1.4183 0.74187 0.96493 0.98772 0.96681 Hydrolase cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;cation binding;hydrolase activity;hydrolase activity, acting on ester bonds;ion binding;magnesium ion binding;metal ion binding;phosphatase activity;phosphoric ester hydrolase activity;pyridoxal phosphatase activity metabolic process Vitamin B6 metabolism 8 8 8 41.6 41.6 41.6 31.698 1.1837E-222 117200000 61758000 55446000 1911 IPI:IPI00025340.3 Pyridoxal phosphate phosphatase PDXP;PLP;PLPP Q96GD0 ENST00000215904 K07758 1 0.85931 1.4732 0.88072 1.1588 0.95083 1.1247 adh_short cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part 3-hydroxybutyrate dehydrogenase activity;binding;catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor metabolic process;oxidation reduction Butanoate metabolism;Synthesis and degradation of ketone bodies 5 5 5 14.9 14.9 14.9 38.157 1.3974E-18 14780000 7823300 6956500 1912 IPI:IPI00025341.2 D-beta-hydroxybutyrate dehydrogenase, mitochondrial;3-hydroxybutyrate dehydrogenase BDH1;BDH Q02338 ENST00000358186;ENST00000392378;ENST00000392379 K00019 1 0.89439 NaN 0.85716 1.0684 NaN 1.1539 zf-CHCC cytoplasmic part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;mitochondrial membrane part;mitochondrial part;mitochondrial respiratory chain complex I;NADH dehydrogenase complex;organelle part;protein complex catalytic activity;electron carrier activity;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH cellular metabolic process;cellular process;electron transport chain;generation of precursor metabolites and energy;metabolic process;mitochondrial electron transport, NADH to ubiquinone;respiratory electron transport chain;transport Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 2 2 2 21.8 21.8 21.8 13.711 3.2663E-17 114210000 57086000 57127000 1913 IPI:IPI00025344.1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial;NADH-ubiquinone oxidoreductase 13 kDa-A subunit;Complex I-13kD-A NDUFS6 O75380 ENST00000274137 K03939 1 0.79362 2.7666 NaN 1.0643 1.7854 NaN Pex14_N integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intrinsic to membrane;macromolecular complex;membrane;membrane-bounded organelle;microbody;microbody membrane;nucleus;organelle;organelle membrane;peroxisomal membrane binding;protein binding;protein N-terminus binding;transcription cofactor activity;transcription corepressor activity;transcription factor binding;transcription regulator activity;transcription repressor activity intracellular protein transport;negative regulation of biosynthetic process;protein complex assembly;protein targeting;protein targeting to peroxisome;regulation of biosynthetic process;regulation of transcription, DNA-dependent;transport 4 4 4 20.7 20.7 20.7 41.236 6.6434E-63 45133000 29154000 15979000 1914 IPI:IPI00025346.3;IPI:IPI00922479.1 Peroxisomal membrane protein PEX14;Peroxisomal membrane anchor protein PEX14;Peroxin-14;PTS1 receptor-docking protein PEX14 O75381-1;O75381;O75381-2 ENST00000356607 2 0.73796 1.4483 0.74356 1.0081 0.95814 0.97421 EMG1 intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nucleolus;organelle;organelle part;ribonucleoprotein complex;small nucleolar ribonucleoprotein complex cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 9 9 9 49.2 49.2 49.2 26.72 1.5756E-237 329920000 167780000 162150000 1915 IPI:IPI00025347.4 Probable ribosome biogenesis protein NEP1;Nucleolar protein EMG1 homolog;Protein C2f EMG1;C2F Q92979 ENST00000261406 1 0.88138 1.7614 0.88155 1.1482 1.1682 1.1571 Citrate_synt cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part catalytic activity;citrate (Si)-synthase activity;transferase activity;transferase activity, transferring acyl groups;transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer acetyl-CoA metabolic process;carbohydrate metabolic process;catabolic process;cellular metabolic process;cellular process;coenzyme catabolic process;coenzyme metabolic process;metabolic process;primary metabolic process;tricarboxylic acid cycle Citrate cycle (TCA cycle);Glyoxylate and dicarboxylate metabolism 13 13 13 30 30 30 51.712 5.1764E-102 2904800000 1484200000 1420700000 1916 IPI:IPI00025366.4 Citrate synthase, mitochondrial CS O75390 ENST00000351328 K01647 1 0.82801 1.6867 0.82646 1.1126 1.0736 1.0639 FG-GAP;Integrin_alpha;Integrin_alpha2;VWA cell part;integrin complex;macromolecular complex;membrane part;plasma membrane part;protein complex;receptor complex binding;calcium ion binding;cation binding;cell adhesion molecule binding;ion binding;magnesium ion binding;metal ion binding;molecular transducer activity;protein binding;receptor activity;signal transducer activity cell activation;cell activation during immune response;lymphocyte activation during immune response;T cell activation during immune response;T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 6 6 6 5.7 5.7 5.7 134.43 4.3191E-176 39433000 21803000 17631000 1917 IPI:IPI00219896.2;IPI:IPI00025380.2 Integrin alpha-L;Leukocyte adhesion glycoprotein LFA-1 alpha chain;Leukocyte function-associated molecule 1 alpha chain;CD11 antigen-like family member A ITGAL;CD11A P20701-2;P20701;P20701-1 ENST00000315171;ENST00000356798 2 1.2645 2.5482 1.4526 1.6538 1.7875 1.8278 SRCR cell part;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part binding;molecular transducer activity;protein binding;receptor activity;scavenger receptor activity;signal transducer activity;transmembrane receptor activity cell proliferation;cell recognition;cellular process Hematopoietic cell lineage 11 11 11 30.3 30.3 30.3 54.624 9.9032E-231 355740000 171800000 183940000 1918 IPI:IPI00025383.1 T-cell surface glycoprotein CD5;Lymphocyte antigen T1/Leu-1 CD5;LEU1 P06127 ENST00000347785 K06455 1 0.22579 NaN NaN 0.28417 NaN NaN PH;RhoGEF cell part;intracellular enzyme regulator activity;GTPase regulator activity;guanyl-nucleotide exchange factor activity;Ras guanyl-nucleotide exchange factor activity;Rho guanyl-nucleotide exchange factor activity;small GTPase regulator activity cell death;cellular process;death;regulation of biological process;regulation of cell communication;regulation of Ras protein signal transduction;regulation of Rho protein signal transduction;regulation of signal transduction 3 2 2 2.2 1.7 1.7 130.8 5.6795E-11 640250 271220 369030 1920 IPI:IPI00025442.2;IPI:IPI00646992.1 Puratrophin-1;Pleckstrin homology domain-containing family G member 4;Purkinje cell atrophy-associated protein 1 PLEKHG4;PRTPHN1 Q58EX7-1;Q58EX7;Q58EX7-2 ENST00000360461;ENST00000379344;ENST00000393966 2 0.72487 1.3196 0.67531 0.94694 0.88235 0.91286 DEAD;Helicase_C cell part;cytoplasmic part;cytosol;eukaryotic translation initiation factor 4F complex;intracellular part;macromolecular complex;protein complex ATP binding;binding;catalytic activity;helicase activity;mRNA binding;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;RNA binding;RNA cap binding;translation initiation factor activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 38 38 23 77.6 77.6 53 46.153 0 21222000000 11272000000 9950000000 1921 IPI:IPI00025491.1 Eukaryotic initiation factor 4A-I;ATP-dependent RNA helicase eIF4A-1 EIF4A1;DDX2A;EIF4A P60842 ENST00000293831;ENST00000380512 K03257 1 3.0072 2.5408 5.1139 3.9278 1.7694 6.5392 HSP20 cell surface;cytoplasm;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle;organelle part;spindle binding;identical protein binding;protein binding anti-apoptosis;cell death;cell motion;regulation of translation;regulation of translational initiation;response to biotic stimulus;response to heat;response to stress;response to temperature stimulus;response to unfolded protein MAPK signaling pathway;VEGF signaling pathway 3 3 3 21 21 21 22.782 5.6585E-30 60456000 21497000 38959000 1922 IPI:IPI00025512.2 Heat shock protein beta-1;Heat shock 27 kDa protein;HSP 27;Stress-responsive protein 27;Estrogen-regulated 24 kDa protein;28 kDa heat shock protein HSPB1;HSP27;HSP28 P04792 ENST00000248553 K04455 1 0.47356 0.80443 0.43412 0.61158 0.55893 0.58906 DNA_pol_E_B cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;catalytic activity;DNA binding;DNA polymerase activity;DNA-directed DNA polymerase activity;nucleic acid binding;nucleotidyltransferase activity;protein binding;transferase activity;transferase activity, transferring phosphorus-containing groups biosynthetic process;DNA metabolic process;DNA replication;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleotide-excision repair, DNA gap filling DNA replication;Nucleotide excision repair 9 9 9 28.1 28.1 28.1 51.289 3.1405E-126 327240000 179100000 148140000 1923 IPI:IPI00025616.1 DNA polymerase delta subunit 2;DNA polymerase delta subunit p50 POLD2 P49005 ENST00000223361;ENST00000395803;ENST00000406581 K02328 1 NaN NaN 0.28088 NaN NaN 0.38592 zf-A20;zf-AN1 binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding 2 1 1 15.5 8.5 8.5 23.132 2.4877E-60 6615000 4249400 2365600 1924 IPI:IPI00025622.3 AN1-type zinc finger protein 5;Zinc finger A20 domain-containing protein 2;Zinc finger protein 216 ZFAND5;ZA20D2;ZNF216 O76080 ENST00000237937;ENST00000343431;ENST00000376956;ENST00000376960;ENST00000376962 1 0.73793 1.2321 0.7523 0.99025 0.84619 0.93595 Actin cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle binding;protein binding 4 4 4 7.9 7.9 7.9 70.483 1.7252E-21 31465000 17622000 13843000 1925 IPI:IPI00025646.5 Actin-related protein 8;INO80 complex subunit N ACTR8;INO80N Q9H981 ENST00000335754 K11673 1 0.66264 1.6172 0.78762 0.89145 1.0236 1.0438 F-box;YccV-like cell part;intracellular part;macromolecular complex;protein complex;ubiquitin ligase complex acid-amino acid ligase activity;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;small conjugating protein ligase activity;ubiquitin-protein ligase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process 2 2 2 3.8 3.8 3.8 72.269 9.4594E-29 5342000 2994600 2347400 1926 IPI:IPI00069507.1;IPI:IPI00025647.1 F-box only protein 21 FBXO21;FBX21;KIAA0875 O94952-2;O94952;O94952-1 ENST00000330622 K10301 2 0.93231 1.0471 0.62742 1.2827 0.68618 0.87964 TACC cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding cell cycle;cell division;cellular process 5 5 4 6.2 6.2 5.3 89.217 1.0958E-12 28286000 15262000 13023000 1927 IPI:IPI00550627.1;IPI:IPI00025683.2;IPI:IPI00939900.1;IPI:IPI00428263.1;IPI:IPI00549229.1;IPI:IPI00216765.2;IPI:IPI00332794.2;IPI:IPI00550465.1;IPI:IPI00935164.2;IPI:IPI00384450.4 Transforming acidic coiled-coil-containing protein 1;Taxin 1;Gastric cancer antigen Ga55 TACC1;KIAA1103 O75410-2;O75410;O75410-1;O75410-7;O75410-6;O75410-3;O75410-4;O75410-5;O75410-8 ENST00000276520;ENST00000317827;ENST00000330691;ENST00000348567;ENST00000379931 10 0.50834 0.96733 0.44101 0.64328 0.67253 0.60274 PGAM;SH3_1;UBA cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 10 10 10 15.1 15.1 15.1 74.122 2.6884E-83 365380000 199140000 166240000 1929 IPI:IPI00025707.1;IPI:IPI00215661.1 Ubiquitin-associated and SH3 domain-containing protein A;Suppressor of T-cell receptor signaling 2;Cbl-interacting protein 4;T-cell ubiquitin ligand UBASH3A;STS2 P57075-1;P57075;P57075-2 ENST00000291535;ENST00000319294 2 0.53566 1.2277 0.50646 0.72796 0.72041 0.6933 cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 3 3 3 16.6 16.6 16.6 33.224 6.6894E-66 68724000 39514000 29210000 1930 IPI:IPI00025710.1 Uncharacterized protein C21orf59 C21orf59;C21orf48 P57076 ENST00000290155 1 NaN 4.8256 NaN NaN 3.391 NaN Ank;Pkinase cell part;cytoplasm;intracellular part;membrane ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;receptor activity;signal transducer activity;transferase activity cellular biopolymer metabolic process;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process 3 3 3 4.6 4.6 4.6 91.61 5.3071E-09 1316700 834590 482100 1931 IPI:IPI00025714.1;IPI:IPI00215935.3 Receptor-interacting serine/threonine-protein kinase 4;Ankyrin repeat domain-containing protein 3;PKC-delta-interacting protein kinase RIPK4;ANKRD3;DIK P57078-1;P57078;P57078-2 ENST00000332512;ENST00000352483 2 0.74303 1.6303 0.78343 1.0075 1.0988 1.0598 Tom37 cell part;cytoplasmic part;intracellular organelle part;intracellular part;membrane;mitochondrial membrane;mitochondrial outer membrane;mitochondrial part;organelle membrane;organelle outer membrane;organelle part;outer membrane establishment of localization;establishment of protein localization;intracellular protein transport;intracellular transport;mitochondrial transport;protein import;protein targeting;protein targeting to mitochondrion;protein transport;transport 6 6 6 28.1 28.1 28.1 29.763 1.8154E-45 174740000 89632000 85109000 1932 IPI:IPI00025717.1 Metaxin-2;Mitochondrial outer membrane import complex protein 2 MTX2 O75431 ENST00000249442 1 0.4999 0.95875 NaN 0.67078 0.60166 NaN WD40 cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;protein binding cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA modification;RNA processing;tRNA metabolic process;tRNA modification;tRNA processing 5 5 5 18.7 18.7 18.7 45.489 7.6175E-107 15012000 8454800 6557500 1933 IPI:IPI00025718.2;IPI:IPI00929723.1;IPI:IPI00929688.1 tRNA (guanine-N(7)-)-methyltransferase subunit WDR4;WD repeat-containing protein 4 WDR4 P57081-1;P57081;P57081-2;P57081-3 ENST00000330317;ENST00000398208 3 0.69311 1.4785 0.80079 0.95725 0.97274 1.0102 PCI cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex;signalosome binding;protein binding biological regulation;cell communication;cellular process;regulation of biological process;regulation of cellular process;response to abiotic stimulus;response to light stimulus;response to radiation;response to stimulus;signal transduction 8 8 8 27.4 27.4 27.4 47.873 1.6174E-220 407230000 213860000 193380000 1934 IPI:IPI00025721.3 COP9 signalosome complex subunit 3;JAB1-containing signalosome subunit 3 COPS3;CSN3 Q9UNS2 ENST00000268717 K12177 1 0.87117 1.4685 0.91339 1.0761 0.95906 1.0887 cell part;cytoplasmic part;endoplasmic reticulum;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane part;membrane-bounded organelle;organelle binding;protein binding defense response;response to stimulus;response to stress 3 3 3 13.5 13.5 13.5 32.952 0.0050597 25991000 13273000 12719000 1935 IPI:IPI00025729.1 Calcium signal-modulating cyclophilin ligand CAMLG;CAML P49069 ENST00000297156 1 0.068902 11.322 0.078205 0.094679 7.5115 0.10097 Cadherin;Cadherin_C anchoring junction;cell junction;cell part;cell-cell junction;cytoplasmic part;cytosol;desmosome;integral to membrane;intracellular part;intrinsic to membrane;membrane part;plasma membrane part binding;calcium ion binding;cation binding;ion binding;metal ion binding;protein binding;toxin binding anatomical structure formation;biological adhesion;calcium-dependent cell-cell adhesion;cell adhesion;cell-cell adhesion;cell-cell junction assembly;cellular component assembly;cellular component organization;cellular process;homophilic cell adhesion + 15 15 15 20.7 20.7 20.7 113.71 0 91106000 88996000 2109600 1937 IPI:IPI00025753.1 Desmoglein-1;Desmosomal glycoprotein 1;Pemphigus foliaceus antigen DSG1;CDHF4 Q02413 ENST00000257192 K07596 1 0.78393 1.5203 0.76668 1.0527 1.0035 1.0245 Complex1_30kDa cytoplasmic part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;mitochondrial membrane part;mitochondrial part;mitochondrial respiratory chain complex I;NADH dehydrogenase complex;organelle part;protein complex binding;catalytic activity;electron carrier activity;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;protein binding cellular process;generation of precursor metabolites and energy;induction of apoptosis;metabolic process;mitochondrial electron transport, NADH to ubiquinone;oxygen and reactive oxygen species metabolic process;regulation of cell growth;transport Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 14 14 14 46.6 46.6 46.6 30.241 5.9523E-263 305210000 157290000 147920000 1939 IPI:IPI00025796.3 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial;NADH-ubiquinone oxidoreductase 30 kDa subunit;Complex I-30kD NDUFS3 O75489 ENST00000263774 K03936 1 0.32 1.3103 NaN 0.39063 0.91457 NaN MGAT2 cell fraction;cytoplasmic part;Golgi apparatus part;Golgi membrane;Golgi stack;insoluble fraction;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane fraction;membrane part;organelle membrane;organelle part acetylglucosaminyltransferase activity;alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity;catalytic activity;transferase activity;transferase activity, transferring glycosyl groups;UDP-glycosyltransferase activity biosynthetic process;carbohydrate biosynthetic process;carbohydrate metabolic process;metabolic process;oligosaccharide biosynthetic process;oligosaccharide metabolic process;primary metabolic process N-Glycan biosynthesis 2 2 2 6.2 6.2 6.2 52.297 8.9282E-23 2878300 1748300 1130000 1941 IPI:IPI00025809.2 Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase;Mannoside acetylglucosaminyltransferase 2;N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II;Beta-1,2-N-acetylglucosaminyltransferase II;GlcNAc-T II MGAT2 Q10469 ENST00000305386 K00736 1 0.87917 1.5378 0.82008 1.0621 0.98135 1.1044 RRM_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cytoskeletal protein binding;DNA binding;microtubule binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding;transcription factor activity;transcription regulator activity;tubulin binding mRNA processing;nuclear division;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;RNA processing;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent 8 8 8 32.2 32.2 32.2 44.991 2.123E-208 783050000 416890000 366160000 1942 IPI:IPI00025815.2 TAR DNA-binding protein 43 TARDBP;TDP43 Q13148 ENST00000240185 1 1.1363 1.7698 1.1628 1.4648 1.2762 1.4533 Cyclin_C;Cyclin_N cell part;cyclin-dependent protein kinase holoenzyme complex;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;protein complex binding;enzyme binding;kinase binding;protein binding;protein kinase binding cell cycle;cellular process;positive regulation of metabolic process;positive regulation of protein amino acid phosphorylation;regulation of cyclin-dependent protein kinase activity;regulation of protein amino acid phosphorylation 3 3 3 10.3 10.3 10.3 32.519 2.1663E-16 33430000 16878000 16552000 1943 IPI:IPI00025817.2 G1/S-specific cyclin-D3 CCND3 P30281 ENST00000372991 1 0.87976 2.038 0.98556 1.0818 1.3563 1.3304 Glycos_transf_2;Ricin_B_lectin cell part;cytoplasmic part;extracellular region;Golgi apparatus part;Golgi cisterna membrane;Golgi membrane;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part acetylgalactosaminyltransferase activity;binding;calcium ion binding;catalytic activity;polypeptide N-acetylgalactosaminyltransferase activity;sugar binding;transferase activity;UDP-glycosyltransferase activity carbohydrate metabolic process;cellular process;metabolic process;peptidyl-amino acid modification;peptidyl-serine modification;protein amino acid glycosylation;protein amino acid O-linked glycosylation;protein modification process O-Glycan biosynthesis 3 3 3 6.4 6.4 6.4 64.218 1.8832E-22 15238000 8252500 6985000 1944 IPI:IPI00025818.1 Polypeptide N-acetylgalactosaminyltransferase 1;Protein-UDP acetylgalactosaminyltransferase 1;UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1;Polypeptide GalNAc transferase 1;Polypeptide N-acetylgalactosaminyltransferase 1 soluble form GALNT1 Q10472-1;Q10472 ENST00000269195;ENST00000392829 K00710 1 NaN NaN 0.29964 NaN NaN 0.39882 Pkinase cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part catalytic activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;protein tyrosine kinase activity;purine nucleoside binding cellular component organization;cellular process;metabolic process;mitosis;nuclear division;organelle organization;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein modification process Cell cycle 2 2 2 5.9 5.9 5.9 71.597 1.6583E-36 906960 436900 470070 1945 IPI:IPI00025830.1 Wee1-like protein kinase;Wee1A kinase;WEE1hu WEE1 P30291 ENST00000299613 K06632 1 0.65568 1.5182 0.71014 0.89153 0.93703 0.95994 LRR_1 cell part;cytoplasmic part;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle;perinuclear region of cytoplasm binding;protein binding cell communication;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleocytoplasmic transport;regulation of transcription, DNA-dependent;signal transduction;transcription;transport 11 8 8 55 47.4 47.4 28.585 6.6062E-165 2319600000 1118700000 1200900000 1946 IPI:IPI00025849.1;IPI:IPI00018262.1 Acidic leucine-rich nuclear phosphoprotein 32 family member A;Potent heat-stable protein phosphatase 2A inhibitor I1PP2A;Acidic nuclear phosphoprotein pp32;Leucine-rich acidic nuclear protein;Putative HLA-DR-associated protein I;Mapmodulin ANP32A;C15orf1;LANP;MAPM;PHAP1 P39687 ENST00000409628 2 0.82335 1.6336 0.78679 1.1066 1.1505 0.99252 Melibiase cell part;cytoplasmic part;extracellular region;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;lysosome;lytic vacuole;membrane-bounded organelle;organelle;vacuole alpha-galactosidase activity;binding;catalytic activity;galactosidase activity;hydrolase activity;hydrolase activity, acting on glycosyl bonds;hydrolase activity, hydrolyzing O-glycosyl compounds;identical protein binding;protein binding;receptor binding carbohydrate metabolic process;ceramide metabolic process;glycolipid metabolic process;glycosphingolipid metabolic process;glycosylceramide metabolic process;lipid metabolic process;membrane lipid metabolic process;sphingolipid metabolic process Galactose metabolism;Glycerolipid metabolism;Glycosphingolipid biosynthesis - globo series;Sphingolipid metabolism 4 4 4 10.3 10.3 10.3 48.766 1.9274E-19 56531000 30532000 26000000 1948 IPI:IPI00025869.1 Alpha-galactosidase A;Alpha-D-galactoside galactohydrolase;Alpha-D-galactosidase A;Melibiase GLA P06280 ENST00000218516 K01189 1 0.84778 1.8247 0.86776 1.1104 1.2142 1.1196 Ribophorin_I cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;endoplasmic reticulum membrane;integral to membrane;intrinsic to membrane;membrane;oligosaccharyltransferase complex;organelle membrane;rough endoplasmic reticulum membrane;vesicle binding;catalytic activity;dolichyl-diphosphooligosaccharide-protein glycotransferase activity;oligosaccharyl transferase activity;protein binding;transferase activity;transferase activity, transferring glycosyl groups carbohydrate metabolic process;cellular process;metabolic process;peptidyl-amino acid modification;peptidyl-asparagine modification;protein amino acid glycosylation;protein amino acid N-linked glycosylation;protein modification process N-Glycan biosynthesis 30 30 30 56.5 56.5 56.5 72.777 0 3053200000 1601800000 1451400000 1949 IPI:IPI00025874.2 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1;Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit;Ribophorin-1;Ribophorin I RPN1 P04843 ENST00000296255 K00730 1 0.76921 1.4233 0.75419 1.0019 0.97874 0.92843 NatB_MDM20 binding;protein binding 17 17 17 19.7 19.7 19.7 112.29 1.7995E-193 188580000 100390000 88191000 1950 IPI:IPI00025890.4;IPI:IPI00852843.1 TPR repeat-containing protein C12orf30;p120 C12orf30;NAP1 Q14CX7-1;Q14CX7;Q14CX7-2 ENST00000261745 2 1.0859 1.8416 0.95022 1.3795 1.2077 1.2577 Snf7 cell part;cytoplasmic part;cytosol;endosomal part;endosome membrane;intracellular organelle part;intracellular part;late endosome membrane;membrane;organelle membrane;organelle part establishment of localization;establishment of protein localization;protein transport;transport 5 5 5 34.8 34.8 34.8 24.95 3.0679E-87 332300000 162560000 169750000 1951 IPI:IPI00025974.3 Charged multivesicular body protein 4b;Chromatin-modifying protein 4b;Vacuolar protein-sorting-associated protein 32-2;SNF7-2;hSnf7-2;SNF7 homolog associated with Alix 1 CHMP4B;C20orf178;SHAX1 Q9H444 ENST00000217402 K12194 1 NaN 1.9224 0.89351 NaN 1.2424 1.3053 PIG-U cell part;cytoplasmic part;endoplasmic reticulum part;GPI-anchor transamidase complex;intracellular organelle part;intracellular part;macromolecular complex;membrane;membrane part;organelle part;plasma membrane;protein complex attachment of GPI anchor to protein;cellular process;metabolic process;protein metabolic process;protein modification process;regulation of cell communication;regulation of protein kinase cascade;regulation of signal transduction Glycosylphosphatidylinositol(GPI)-anchor biosynthesis 2 2 2 2.8 2.8 2.8 50.051 4.3462E-08 39381000 18255000 21126000 1952 IPI:IPI00026044.3;IPI:IPI00402109.4 Phosphatidylinositol glycan anchor biosynthesis class U protein;GPI transamidase component PIG-U;Cell division cycle protein 91-like 1 PIGU;CDC91L1;PSEC0205;UNQ3055/PRO9875 Q9H490-1;Q9H490;Q9H490-2 ENST00000217446;ENST00000374820 K05293 2 0.90354 1.5206 0.64704 1.1994 1.0154 0.86644 endoplasmic reticulum;Golgi apparatus;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intrinsic to membrane;lysosomal membrane;membrane;membrane-bounded organelle;organelle;organelle membrane;vacuolar membrane binding;protein binding brain development;catabolic process;cellular homeostasis;cellular ion homeostasis;cellular process;developmental maturation;lysosomal lumen acidification;macromolecule catabolic process;metabolic process;protein metabolic process;regulation of pH 4 4 4 8.8 8.8 8.8 46.339 3.9051E-05 18259000 8543100 9716000 1953 IPI:IPI00026050.1 Ceroid-lipofuscinosis neuronal protein 5 CLN5 O75503 ENST00000377453;ENST00000405644 1 NaN 1.7213 NaN NaN 0.9967 NaN Pkinase cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;signal transducer activity;transferase activity cell communication;intracellular signaling cascade;MAPKKK cascade;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein kinase cascade;protein modification process;signal transduction MAPK signaling pathway;VEGF signaling pathway 6 6 4 16 16 11 45.567 1.9918E-10 42527000 23913000 18614000 1954 IPI:IPI00026054.1;IPI:IPI00215763.1 MAP kinase-activated protein kinase 2 MAPKAPK2 P49137-1;P49137;P49137-2 ENST00000294981;ENST00000367103 K04443 2 0.8466 1.8421 0.84608 1.2111 1.168 1.1477 BAF cell part;chromosome;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding cellular process;DNA integration;DNA metabolic process;DNA recombination;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to biotic stimulus;response to virus 11 11 10 71.9 71.9 71.9 10.058 1.261E-235 2578800000 1314700000 1264100000 1955 IPI:IPI00026087.1 Barrier-to-autointegration factor;Breakpoint cluster region protein 1 BANF1;BAF;BCRG1 O75531 ENST00000312175 1 0.84662 1.4455 0.86576 1.1301 0.96785 1.1558 HEAT;SF3b1 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;catalytic activity;protein binding;RNA splicing factor activity, transesterification mechanism nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 53 53 53 47.2 47.2 47.2 145.83 0 4577400000 2319400000 2258000000 1956 IPI:IPI00026089.4 Splicing factor 3B subunit 1;Pre-mRNA-splicing factor SF3b 155 kDa subunit;Spliceosome-associated protein 155 SF3B1;SAP155 O75533 ENST00000335508 1 0.79604 1.7231 0.87597 1.0898 1.0783 1.1852 SCP2;Thiolase_C;Thiolase_N cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;microbody;mitochondrion;organelle;peroxisome acyltransferase activity;binding;C-acyltransferase activity;catalytic activity;lipid binding;oxidoreductase activity;protein binding;steroid binding;sterol carrier activity;transferase activity;transferase activity, transferring acyl groups biosynthetic process;cellular metabolic process;cellular process;lipid biosynthetic process;lipid metabolic process;lipid transport;metabolic process;primary metabolic process;steroid biosynthetic process;steroid metabolic process;transport 15 15 15 27.8 27.8 27.8 58.993 0 1322800000 710750000 612060000 1957 IPI:IPI00026105.1;IPI:IPI00943320.1 Non-specific lipid-transfer protein;Propanoyl-CoA C-acyltransferase;NSL-TP;Sterol carrier protein 2;Sterol carrier protein X;SCP-chi;SCPX SCP2 P22307-1;P22307;P22307-2 ENST00000371514;ENST00000407246 2 1.0186 1.6789 1.0615 1.3138 1.2296 1.381 DUF841 cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;Golgi apparatus part;Golgi membrane;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part 3 3 3 19.7 19.7 19.7 21.175 2.012E-71 109230000 54531000 54696000 1958 IPI:IPI00026111.3;IPI:IPI00761107.1 Transmembrane and coiled-coil domain-containing protein 1;Xenogeneic cross-immune protein PCIA3;Transmembrane and coiled-coil domains protein 4 TMCO1;TMCC4;PNAS-10;PNAS-136;UNQ151/PRO177 Q9UM00-1;Q9UM00;Q9UM00-2 ENST00000367881;ENST00000392129 2 0.97312 1.9944 0.99599 1.3545 1.2689 1.3263 HS1_rep;SH3_1 DNA-directed RNA polymerase complex;DNA-directed RNA polymerase II, core complex;intracellular membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane;membrane-bounded organelle;mitochondrion;organelle;RNA polymerase complex binding;DNA binding;nucleic acid binding;transcription factor activity;transcription regulator activity cell communication;intracellular signaling cascade;positive regulation of protein amino acid phosphorylation;regulation of protein amino acid phosphorylation;regulation of transcription, DNA-dependent;signal transduction Tight junction 16 16 16 38.5 38.5 38.5 53.983 0 1781500000 884340000 897200000 1959 IPI:IPI00026156.2 Hematopoietic lineage cell-specific protein;Hematopoietic cell-specific LYN substrate 1;LckBP1;p75 HCLS1;HS1 P14317 ENST00000314583 K06106 1 0.7315 1.5449 0.75784 0.96654 1.0206 0.98911 Ribosomal_L7Ae intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 6 6 6 56.2 56.2 56.2 14.173 6.1146E-86 1153600000 618690000 534920000 1960 IPI:IPI00026167.5 NHP2-like protein 1;High mobility group-like nuclear protein 2 homolog 1;U4/U6.U5 tri-snRNP 15.5 kDa protein;OTK27;hSNU13 NHP2L1 P55769 ENST00000215956;ENST00000355257;ENST00000401959;ENST00000402458 1 0.89528 1.7115 0.9329 1.2394 1.1158 1.284 F-actin_cap_A cell part;cytoplasm;cytoskeletal part;F-actin capping protein complex;intracellular organelle part;intracellular part;macromolecular complex;organelle part;protein complex actin binding;binding;cytoskeletal protein binding;protein binding cell motion;cellular process;cytoskeleton organization;negative regulation of macromolecule metabolic process;negative regulation of metabolic process;organelle organization;protein complex assembly;regulation of actin polymerization or depolymerization 13 10 10 55.6 44.1 44.1 32.949 0 283210000 141580000 141630000 1961 IPI:IPI00026182.5 F-actin-capping protein subunit alpha-2;CapZ alpha-2 CAPZA2 P47755 ENST00000361183 K10364 1 0.78013 1.3414 0.73415 0.97745 0.8979 0.92721 Ribosomal_L18ae cell part;cytoplasmic part;cytosolic large ribosomal subunit;cytosolic part;intracellular organelle part;intracellular part;large ribosomal subunit;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit binding;nucleic acid binding;protein binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 11 11 11 50.6 50.6 50.6 20.762 1.2174E-171 2446000000 1265300000 1180700000 1962 IPI:IPI00026202.1 60S ribosomal protein L18a RPL18A Q02543 ENST00000222247 K02882 1 0.62374 1.1738 0.62134 0.84755 0.79244 0.84086 XPG_I;XPG_N cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle catalytic activity;damaged DNA binding;DNA binding;double-stranded DNA binding;endodeoxyribonuclease activity;endonuclease activity;endoribonuclease activity;exonuclease activity;nuclease activity;nucleic acid binding;ribonuclease H activity cell communication;DNA metabolic process;DNA repair;DNA replication;double-strand break repair;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to DNA damage stimulus;response to stress Base excision repair;DNA replication;Non-homologous end-joining 15 15 15 46.3 46.3 46.3 42.592 0 1321000000 710350000 610670000 1963 IPI:IPI00026215.1 Flap endonuclease 1;Flap structure-specific endonuclease 1;Maturation factor 1;DNase IV FEN1;RAD2 P39748 ENST00000305885 K04799 1 0.76219 1.4978 0.77735 1.0059 0.98547 1.0073 Peptidase_M1 cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle aminopeptidase activity;binding;catalytic activity;cation binding;exopeptidase activity;hydrolase activity;ion binding;metal ion binding;metallopeptidase activity;peptidase activity;protein binding;transition metal ion binding;zinc ion binding biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis 30 30 30 33.7 33.7 33.7 103.28 0 1281900000 637280000 644660000 1964 IPI:IPI00026216.4;IPI:IPI00455333.4;IPI:IPI00902599.1;IPI:IPI00902662.1 Puromycin-sensitive aminopeptidase NPEPPS;PSA P55786 ENST00000322157 K08776 4 0.53155 1.0073 0.50491 0.64665 0.71706 0.65935 CPSF_A cell part;intracellular organelle part;intracellular part;macromolecular complex;mRNA cleavage and polyadenylation specificity factor complex;mRNA cleavage factor complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;mRNA 3'-UTR binding;mRNA binding;nucleic acid binding;protein binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 21 21 21 16.6 16.6 16.6 160.88 8.2582E-207 307400000 167930000 139460000 1965 IPI:IPI00026219.4 Cleavage and polyadenylation specificity factor subunit 1;Cleavage and polyadenylation specificity factor 160 kDa subunit CPSF1;CPSF160 Q10570 ENST00000349769 1 0.99885 1.6064 0.95707 1.2317 1.1008 1.1813 RRM_1;zf-RNPHF cytoskeleton;heterogeneous nuclear ribonucleoprotein complex;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nucleoplasm;organelle;organelle part;ribonucleoprotein complex binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 11 5 5 30.3 15.1 15.1 49.263 0 304210000 150320000 153890000 1966 IPI:IPI00026230.1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H';FTP-3 HNRNPH2;FTP3;HNRPH2 P55795 ENST00000316594;ENST00000395130 1 0.85959 1.8333 NaN 1.1948 1.1166 NaN 2 2 2 5.4 5.4 5.4 49.618 3.1063E-15 1786500 936420 850050 1967 IPI:IPI00026233.5 Coiled-coil domain-containing protein 71 CCDC71 Q8IV32 ENST00000321895 1 0.90574 2.3154 0.97643 1.1834 1.4729 1.3108 C2;PH;RasGAP;SH2;SH3_1 cell part;cytoplasm;intracellular part auxiliary transport protein activity;binding;enzyme activator activity;glycoprotein binding;GTPase activator activity;ion channel inhibitor activity;protein binding;Ras GTPase activator activity;receptor binding;small GTPase regulator activity cell communication;cytokinesis;intracellular signaling cascade;negative regulation of cell adhesion;negative regulation of cell-matrix adhesion;regulation of cell-matrix adhesion;signal transduction;vasculogenesis Axon guidance;MAPK signaling pathway 3 3 3 2.9 2.9 2.9 116.4 2.0646E-10 6639200 3552600 3086600 1969 IPI:IPI00026262.3;IPI:IPI00220356.1 Ras GTPase-activating protein 1;Ras p21 protein activator;p120GAP RASA1;RASA P20936-1;P20936;P20936-2 ENST00000274376;ENST00000389275 K04352 2 0.89449 1.5126 0.90034 1.1767 1.0059 1.1455 WD40 catalytic activity;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;pyrophosphatase activity;signal transducer activity cell communication;cell surface receptor linked signal transduction;G-protein coupled receptor protein signaling pathway;intracellular signaling cascade;muscarinic acetylcholine receptor signaling pathway;signal transduction Chemokine signaling pathway;Taste transduction 13 13 8 48.8 48.8 30.6 37.377 0 2168500000 1115400000 1053100000 1970 IPI:IPI00026268.3 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Transducin beta chain 1 GNB1 P62873 ENST00000378609 K04536 1 0.71879 1.3532 0.72463 0.98137 0.86475 0.96447 Ribosomal_S11 cytosolic small ribosomal subunit;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nucleolus;organelle;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit binding;mRNA 5'-UTR binding;mRNA binding;nucleic acid binding;protein binding;RNA binding;structural constituent of ribosome;structural molecule activity;translation regulator activity negative regulation of transcription from RNA polymerase II promoter;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;ribosomal small subunit assembly 11 11 11 43 43 43 16.273 4.7102E-267 4203600000 2240700000 1962800000 1971 IPI:IPI00026271.5 40S ribosomal protein S14 RPS14;PRO2640 P62263 ENST00000312037;ENST00000401695;ENST00000407193 1 0.64717 1.484 0.73649 0.87443 0.97396 0.99777 Histone cell part;chromosomal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;macromolecular complex;membrane-bounded organelle;nucleosome;nucleus;organelle;organelle part;protein-DNA complex binding;DNA binding;nucleic acid binding anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;chromatin organization;nucleosome assembly;organelle organization Systemic lupus erythematosus 8 8 2 60.8 60.8 13.8 14.135 5.1345E-226 22712000000 11684000000 11029000000 1972 IPI:IPI00026272.2;IPI:IPI00216456.5;IPI:IPI00031562.3 Histone H2A type 1-B/E;H2A/m;H2A.2;H2A/a;Histone H2A type 1-C;H2A/l;Histone H2A type 3 HIST1H2AB;H2AFM;HIST1H2AE;H2AFA;HIST1H2AC;H2AFL;HIST3H2A P04908;Q93077;Q7L7L0 ENST00000259791;ENST00000303910;ENST00000314088;ENST00000377791;ENST00000396980;ENST00000366695 K11251 3 0.66627 1.3573 0.80007 0.90408 0.83209 0.98323 Ribosomal_L31e cell part;cytoplasmic part;cytosolic large ribosomal subunit;cytosolic part;intracellular organelle part;intracellular part;large ribosomal subunit;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit binding;nucleic acid binding;protein binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 10 10 10 52 52 52 14.463 2.0204E-115 2033500000 1027000000 1006500000 1973 IPI:IPI00026302.3 60S ribosomal protein L31 RPL31 P62899 ENST00000264258;ENST00000409038;ENST00000409733 K02910 1 1.0014 1.6634 0.94187 1.2688 1.0993 1.2153 WD40 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 11 11 11 23.5 23.5 23.5 65.521 4.0656E-63 101820000 49691000 52130000 1974 IPI:IPI00026307.1 Pre-mRNA-processing factor 17;PRP17 homolog;Cell division cycle 40 homolog;EH-binding protein 3 CDC40;EHB3;PRP17;PRPF17 O60508 ENST00000307731;ENST00000368932 1 0.59853 3.5484 0.60523 0.86439 2.0589 0.88059 Geminin cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;protein binding cell cycle;cellular process;negative regulation of biosynthetic process;negative regulation of DNA replication;negative regulation of metabolic process;regulation of biosynthetic process;regulation of DNA replication 3 3 3 16.7 16.7 16.7 23.565 1.3232E-13 20177000 11780000 8397500 1975 IPI:IPI00026309.3 Geminin GMNN O75496 ENST00000378059 K10749 1 0.67618 1.2805 0.69006 0.89522 0.83037 0.85987 HECT;PABP;zf-UBR cell fraction;cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle;soluble fraction acid-amino acid ligase activity;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleic acid binding;protein binding;RNA binding;ubiquitin-protein ligase activity;zinc ion binding cell communication;cell proliferation;intracellular signaling cascade;metabolic process;protein modification process;proteolysis;response to DNA damage stimulus;response to stress;signal transduction;ubiquitin-dependent protein catabolic process Ubiquitin mediated proteolysis 20 20 20 9.5 9.5 9.5 309.35 1.6016E-227 109760000 58720000 51041000 1976 IPI:IPI00026320.1 E3 ubiquitin-protein ligase UBR5;E3 ubiquitin-protein ligase, HECT domain-containing 1;Hyperplastic discs protein homolog;Progestin-induced protein UBR5;EDD;EDD1;HYD;KIAA0896 O95071 ENST00000220959 K10593 1 0.7956 1.6205 0.86408 1.0778 1.0225 1.119 endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;membrane-enclosed lumen;organelle;organelle lumen;organelle part catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on sulfur group of donors;oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor;protein-disulfide reductase (glutathione) activity biological regulation;cell redox homeostasis;cellular homeostasis;cellular process;homeostatic process;metabolic process;oxidation reduction;regulation of biological process;regulation of biological quality;regulation of cellular process Glutathione metabolism 6 6 6 36 36 36 19.206 3.6211E-216 325760000 168430000 157330000 1977 IPI:IPI00026328.3 Thioredoxin domain-containing protein 12;Thioredoxin-like protein p19;Endoplasmic reticulum protein ERp19;ERp18;hTLP19 TXNDC12;TLP19;UNQ713/PRO1376 O95881 ENST00000371626 K05360 1 0.96461 1.8492 1.0051 1.2793 1.1892 1.314 Ran_BP1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;enzyme binding;GTPase binding;protein binding;Ran GTPase binding;Ras GTPase binding;small GTPase binding establishment of localization;establishment of localization in cell;establishment of protein localization;intracellular transport;protein transport;transport 8 8 8 16.4 16.4 16.4 60.209 5.0852E-39 260120000 135460000 124660000 1978 IPI:IPI00026337.1;IPI:IPI00456728.3;IPI:IPI00456729.1;IPI:IPI00179121.4 Ran-binding protein 3 RANBP3 Q9H6Z4-1;Q9H6Z4;Q9H6Z4-2;Q9H6Z4-3 ENST00000034275;ENST00000324807;ENST00000340578 4 0.91772 1.9174 0.93829 1.2532 1.2032 1.2595 MAP1_LC3 autophagic vacuole membrane;cell fraction;cytoplasmic part;cytosol;Golgi apparatus part;Golgi membrane;insoluble fraction;intracellular part;membrane;membrane fraction;organelle membrane;organelle part;vacuolar membrane;vacuolar part ATPase binding;beta-tubulin binding;binding;cytoskeletal protein binding;enzyme binding;GABA receptor binding;microtubule binding;protein binding;receptor binding;SNARE binding;tubulin binding autophagy;catabolic process;cellular process;intra-Golgi vesicle-mediated transport;metabolic process;positive regulation of ATPase activity;positive regulation of catalytic activity;protein transport;transport;vesicle-mediated transport Regulation of autophagy 6 6 5 50.4 50.4 50.4 13.667 2.6536E-34 722440000 142500000 579930000 1979 IPI:IPI00026358.3 Gamma-aminobutyric acid receptor-associated protein-like 2;GABA(A) receptor-associated protein-like 2;Golgi-associated ATPase enhancer of 16 kDa;General protein transport factor p16;Ganglioside expression factor 2;MAP1 light chain 3-related protein GABARAPL2;FLC3A;GEF2 P60520 ENST00000037243 K08341 1 0.81664 1.4478 0.45284 1.0185 1.0174 0.63957 RNA_pol_Rpa2_4;RNA_pol_Rpb2_1;RNA_pol_Rpb2_2;RNA_pol_Rpb2_3;RNA_pol_Rpb2_5;RNA_pol_Rpb2_6;RNA_pol_Rpb2_7 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;nucleoplasm;organelle;organelle part binding;catalytic activity;DNA binding;DNA-directed RNA polymerase activity;nucleic acid binding;nucleoside binding;protein binding;transferase activity;transferase activity, transferring phosphorus-containing groups;zinc ion binding biosynthetic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription RNA polymerase 9 9 9 9.5 9.5 9.5 132.17 1.9757E-94 50501000 28215000 22286000 1980 IPI:IPI00418797.5;IPI:IPI00026445.3 DNA-directed RNA polymerase I subunit RPA2;DNA-directed RNA polymerase I 135 kDa polypeptide POLR1B Q9H9Y6-1;Q9H9Y6;Q9H9Y6-2 ENST00000263331 K03002 2 0.85645 1.5142 0.74701 1.1232 0.97543 1.0035 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding cell cycle;cellular process Cell cycle - yeast 17 17 17 7.3 7.3 7.3 316.05 2.9979E-90 247810000 131510000 116300000 1981 IPI:IPI00436632.1;IPI:IPI00026466.9;IPI:IPI00436634.4 Nipped-B-like protein;Delangin;SCC2 homolog NIPBL;IDN3 Q6KC79-1;Q6KC79;Q6KC79-2 ENST00000282516 K06672 3 0.73218 1.4315 0.68971 0.96799 0.89858 0.86924 Aminotran_1_2 acetyltransferase activity;acyltransferase activity;binding;C-acetyltransferase activity;C-acyltransferase activity;catalytic activity;glycine C-acetyltransferase activity;lipid binding;steroid binding;transferase activity amine metabolic process;biosynthetic process;cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;cellular process;metabolic process;nitrogen compound metabolic process;organic acid metabolic process Glycine, serine and threonine metabolism 3 3 3 12.4 12.4 12.4 45.285 7.7275E-64 11977000 6519300 5457800 1982 IPI:IPI00026492.3 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial;Glycine acetyltransferase;Aminoacetone synthetase GCAT;KBL O75600 ENST00000248924;ENST00000323205 K00639 1 0.75541 1.1976 0.71807 0.90209 0.8182 0.90212 Nucleoplasmin binding;nucleic acid binding 3 3 3 29.2 29.2 29.2 19.343 0 1103000000 568990000 534060000 1983 IPI:IPI00026496.3 Nucleoplasmin-3 NPM3 O75607 ENST00000370110 K11278 1 0.5984 1.0671 0.61263 0.8201 0.69022 0.87667 MMR_HSR1 cell part;intracellular binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleic acid binding;nucleotide binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding;RNA binding 4 4 4 13.5 13.5 13.5 48.349 2.9808E-11 47717000 25829000 21887000 1984 IPI:IPI00026512.2;IPI:IPI00216548.4 GTP-binding protein era homolog;ERA-W;Conserved ERA-like GTPase ERAL1;HERA O75616-1;O75616;O75616-2 ENST00000254928 2 0.73165 1.3696 0.80869 0.97567 0.94328 1.049 Rib_5-P_isom_A cell part;cytoplasmic part;cytosol;intracellular part catalytic activity;intramolecular oxidoreductase activity;intramolecular oxidoreductase activity, interconverting aldoses and ketoses;isomerase activity;ribose-5-phosphate isomerase activity alcohol metabolic process;carbohydrate metabolic process;metabolic process;monosaccharide metabolic process;pentose metabolic process;pentose-phosphate shunt, non-oxidative branch;primary metabolic process Carbon fixation in photosynthetic organisms;Pentose phosphate pathway 12 12 12 46.9 46.9 46.9 33.269 0 705610000 367910000 337700000 1985 IPI:IPI00026513.6 Ribose-5-phosphate isomerase;Phosphoriboisomerase RPIA;RPI P49247 ENST00000283646 K01807 1 0.79256 1.5868 0.76695 1.0326 1.0334 1.02 CoA_trans cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part 3-oxoacid CoA-transferase activity;binding;catalytic activity;CoA-transferase activity;identical protein binding;protein binding;protein homodimerization activity;transferase activity;transferase activity, transferring sulfur-containing groups catabolic process;cellular catabolic process;cellular ketone body metabolic process;cellular metabolic process;cellular process;ketone body catabolic process;metabolic process Butanoate metabolism;Synthesis and degradation of ketone bodies;Valine, leucine and isoleucine degradation 18 18 17 45.8 45.8 43.5 56.157 0 683760000 367790000 315970000 1986 IPI:IPI00026516.1 Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial;3-oxoacid-CoA transferase 1;Somatic-type succinyl CoA:3-oxoacid CoA-transferase OXCT1;OXCT;SCOT P55809 ENST00000196371 K01028;K01029 1 0.69577 1.4615 NaN 0.95665 0.93723 NaN Pro_isomerase cell fraction;cell part;cytoplasmic part;insoluble fraction;intracellular organelle part;intracellular part;membrane fraction;mitochondrial matrix;mitochondrial part;organelle part binding;catalytic activity;cis-trans isomerase activity;isomerase activity;peptide binding;peptidyl-prolyl cis-trans isomerase activity biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 7 6 6 31.9 28.5 28.5 22.04 1.0151E-18 90787000 49505000 41283000 1987 IPI:IPI00026519.1;IPI:IPI00457283.2 Peptidyl-prolyl cis-trans isomerase, mitochondrial;Cyclophilin F PPIF;CYP3 P30405 ENST00000225174 K09565 2 1.0244 2.1208 1.1171 1.361 1.3636 1.3958 Lectin_leg-like endoplasmic reticulum membrane;endoplasmic reticulum part;ER-Golgi intermediate compartment membrane;Golgi apparatus part;Golgi membrane;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part binding;carbohydrate binding;mannose binding;monosaccharide binding;protein binding;sugar binding;unfolded protein binding blood coagulation;cellular process;ER to Golgi vesicle-mediated transport;hemostasis;metabolic process;multicellular organismal process;protein folding;protein metabolic process;protein transport;transport;vesicle-mediated transport 13 13 12 37.5 37.5 36.3 57.548 2.1661E-136 813080000 423600000 389490000 1988 IPI:IPI00026530.4 Protein ERGIC-53;ER-Golgi intermediate compartment 53 kDa protein;Lectin mannose-binding 1;Gp58;Intracellular mannose-specific lectin MR60 LMAN1;ERGIC53;F5F8D P49257 ENST00000251047 K10080 1 0.95563 2.0776 1.0139 1.1843 1.4626 1.2628 Lipase_GDSL cell part;cytoplasm;intracellular part 1-alkyl-2-acetylglycerophosphocholine esterase activity;carboxylesterase activity;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds catabolic process;lipid catabolic process;lipid metabolic process;metabolic process;primary metabolic process Ether lipid metabolism 4 4 4 27.5 27.5 27.5 25.569 2.5898E-132 152010000 79991000 72016000 1989 IPI:IPI00026546.1 Platelet-activating factor acetylhydrolase IB subunit beta;PAF acetylhydrolase 30 kDa subunit;PAF-AH subunit beta;PAFAH subunit beta PAFAH1B2;PAFAHB P68402 ENST00000304808 K01062 1 0.81262 1.7316 0.81505 1.0841 1.1232 1.0979 COX7a cell part;cytoplasmic part;intracellular organelle part;intracellular part;membrane part;mitochondrial membrane part;mitochondrial part;mitochondrial respiratory chain;organelle part;respiratory chain catalytic activity;cation transmembrane transporter activity;cytochrome-c oxidase activity;electron carrier activity;heme-copper terminal oxidase activity;ion transmembrane transporter activity;transporter activity Alzheimer's disease;Cardiac muscle contraction;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 3 3 3 21.7 21.7 21.7 12.844 4.7334E-47 368210000 190620000 177600000 1991 IPI:IPI00026570.2 Cytochrome c oxidase polypeptide 7A2, mitochondrial;Cytochrome c oxidase polypeptide VIIa-liver/heart COX7A2;COX7AL P14406 ENST00000230459;ENST00000370081;ENST00000370089 K02270 1 0.63365 1.3636 0.7396 0.85628 0.85876 0.99575 SURF6 cell part;granular component;intracellular organelle part;intracellular part;nuclear part;nucleolar part;organelle part binding;DNA binding;nucleic acid binding;RNA binding 6 6 6 16.1 16.1 16.1 41.45 2.352E-09 129650000 68125000 61524000 1992 IPI:IPI00026606.2 Surfeit locus protein 6 SURF6;SURF-6 O75683 ENST00000372022 1 1.1302 1.6651 1.0666 1.4302 1.1501 1.4661 PP2C;PP2C_C cell part;macromolecular complex;protein complex;protein serine/threonine phosphatase complex binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;magnesium ion binding;manganese ion binding;phosphatase activity;phosphoprotein phosphatase activity;protein binding;protein serine/threonine phosphatase activity cellular biopolymer metabolic process;cellular process;dephosphorylation;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid dephosphorylation;protein metabolic process;protein modification process 6 4 4 14 9.4 9.4 52.642 1.0484E-42 14768000 6883700 7884700 1993 IPI:IPI00026612.1;IPI:IPI00743802.1 Protein phosphatase 1B;Protein phosphatase 2C isoform beta PPM1B;PP2CB O75688-1;O75688;O75688-2 ENST00000282412;ENST00000378551 2 0.62955 1.16 0.59192 0.79902 0.79231 0.76164 Nucleoporin cell part;intracellular organelle part;intracellular part;macromolecular complex;membrane;membrane part;nuclear membrane;nuclear part;nuclear pore;organelle membrane;organelle part;pore complex;protein complex structural constituent of nuclear pore;structural molecule activity;transporter activity cellular process;establishment of protein localization;intracellular protein transport;intracellular transport;nucleic acid transport;nucleobase, nucleoside, nucleotide and nucleic acid transport;nucleocytoplasmic transport;protein transport;transport 22 22 22 22.7 22.7 22.7 155.2 0 467610000 255870000 211740000 1994 IPI:IPI00026625.1;IPI:IPI00376609.1 Nuclear pore complex protein Nup155;Nucleoporin Nup155;155 kDa nucleoporin NUP155;KIAA0791 O75694-1;O75694;O75694-2 ENST00000231498;ENST00000381843 2 0.80888 1.5301 0.81061 1.0957 1.018 1.0859 TBCC cell part;membrane;plasma membrane ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleoside diphosphate kinase activity;nucleotide binding;protein binding;purine nucleoside binding;transferase activity GTP biosynthetic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;pyrimidine nucleoside metabolic process;system process 6 6 6 20.3 20.3 20.3 39.641 1.0985E-42 65637000 34119000 31518000 1995 IPI:IPI00026627.4 Protein XRP2 RP2 O75695 ENST00000218340 1 0.85012 1.5595 0.88352 1.1242 0.99475 1.1829 cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;protein binding nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein complex assembly;proteolysis;regulation of transcription, DNA-dependent;RNA elongation;RNA elongation from RNA polymerase II promoter Pathways in cancer;Renal cell carcinoma;Ubiquitin mediated proteolysis 9 9 9 52.5 52.5 52.5 13.133 3.0102E-59 760810000 393030000 367770000 1996 IPI:IPI00026670.3 Transcription elongation factor B polypeptide 2;RNA polymerase II transcription factor SIII subunit B;SIII p18;Elongin B;Elongin 18 kDa subunit TCEB2 Q15370 ENST00000262306;ENST00000409906 K03873 1 0.24265 0.52827 0.25218 0.31957 0.35116 0.32262 Pkinase cell part;cytoplasmic part;cytoskeletal part;cytosol;intracellular organelle part;intracellular part;microtubule;midbody;nuclear part;nucleoplasm;organelle part;spindle microtubule ATP binding;binding;catalytic activity;cyclin-dependent protein kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding anti-apoptosis;mitosis;nuclear division;organelle organization;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;proteolysis;ubiquitin-dependent protein catabolic process 22 22 20 73.3 73.3 67 34.778 0 2733200000 1659500000 1073700000 1997 IPI:IPI00026689.4;IPI:IPI00073536.2;IPI:IPI00414292.3;IPI:IPI00394661.4;IPI:IPI00914963.1 Cell division control protein 2 homolog;p34 protein kinase;Cyclin-dependent kinase 1 CDC2 P06493-1;P06493;P06493-2 ENST00000307250;ENST00000316629;ENST00000373811;ENST00000395284 5 0.43821 0.79758 0.44505 0.57995 0.54095 0.56952 Acyl_transf_1;adh_short;ADH_zinc_N;ketoacyl-synt;Ketoacyl-synt_C;Methyltransf_12;PP-binding;Thioesterase cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;cytosol;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;melanosome;membrane-bounded organelle;membrane-bounded vesicle;organelle;vesicle [acyl-carrier-protein] S-acetyltransferase activity;[acyl-carrier-protein] S-malonyltransferase activity;3-oxoacyl-[acyl-carrier-protein] synthase activity;acyl carrier activity;catalytic activity;fatty-acid synthase activity biosynthetic process;cellular process;fatty acid biosynthetic process;fatty acid metabolic process;lipid biosynthetic process;lipid metabolic process;metabolic process;organic acid biosynthetic process;organic acid metabolic process Fatty acid biosynthesis;Insulin signaling pathway 84 84 84 41.7 41.7 41.7 273.42 0 5609100000 3299500000 2309500000 1999 IPI:IPI00026781.3 Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase FASN;FAS P49327 ENST00000306749 K00665 1 0.35907 NaN NaN 0.50497 NaN NaN Pkinase cell part;intracellular organelle;intracellular organelle part;intracellular part;macromolecular complex;mediator complex;membrane-bounded organelle;nuclear part;nucleoplasm part;nucleus;organelle;organelle part;protein complex ATP binding;binding;catalytic activity;cyclin-dependent protein kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;regulation of transcription, DNA-dependent;transcription 4 4 4 9.1 9.1 9.1 53.283 6.3081E-08 16014000 10737000 5276100 2000 IPI:IPI00026791.1;IPI:IPI00879595.1;IPI:IPI00250316.1;IPI:IPI00170593.2 Cell division protein kinase 8;Cyclin-dependent kinase 8;Mediator of RNA polymerase II transcription subunit CDK8;Mediator complex subunit CDK8;Protein kinase K35;Cell division cycle 2-like protein kinase 6;CDC2-related protein kinase 6;Death-preventing kinase;Cyclin-dependent kinase 11 CDK8;CDC2L6;CDK11;KIAA1028 P49336-1;P49336;P49336-2;Q9BWU1-1;Q9BWU1;Q9BWU1-2 ENST00000381527;ENST00000368911 K02208 4 0.7496 1.3955 0.75796 0.94789 0.92372 0.99254 PPTA cell part;cytoplasmic part;cytosol;intracellular part binding;CAAX-protein geranylgeranyltransferase activity;catalytic activity;prenyltransferase activity;protein binding;protein farnesyltransferase activity;protein geranylgeranyltransferase activity;protein prenyltransferase activity;transferase activity cell communication;cell surface receptor linked signal transduction;enzyme linked receptor protein signaling pathway;protein amino acid lipidation;protein modification process;signal transduction 7 7 7 19.8 19.8 19.8 44.408 4.5018E-107 158200000 85413000 72785000 2001 IPI:IPI00026813.1;IPI:IPI00607601.2 Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha;CAAX farnesyltransferase subunit alpha;Ras proteins prenyltransferase subunit alpha;FTase-alpha;Type I protein geranyl-geranyltransferase subunit alpha FNTA P49354-1;P49354;P49354-2 ENST00000302279 K05955 2 0.68133 1.4464 0.64333 0.92942 0.95973 0.86129 Prenyltrans binding;catalytic activity;prenyltransferase activity;protein binding;protein farnesyltransferase activity;protein prenyltransferase activity;transferase activity;transferase activity, transferring alkyl or aryl (other than methyl) groups;zinc ion binding cellular process;metabolic process;protein amino acid farnesylation;protein amino acid lipidation;protein amino acid prenylation;protein farnesylation;protein metabolic process;protein modification process;protein prenylation 4 4 4 13.3 13.3 13.3 48.773 5.1761E-09 55499000 33545000 21954000 2002 IPI:IPI00026817.3 Protein farnesyltransferase subunit beta;CAAX farnesyltransferase subunit beta;Ras proteins prenyltransferase subunit beta FNTB P49356 ENST00000246166 K05954 1 0.56217 1.4123 0.70202 0.77048 0.88464 0.90447 Heme_oxygenase cell fraction;endoplasmic reticulum;insoluble fraction;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane fraction;membrane-bounded organelle;microsome;organelle;plasma membrane;vesicular fraction binding;catalytic activity;electron carrier activity;heme oxygenase (decyclizing) activity;iron ion binding;oxidoreductase activity;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;protein binding cellular process;heme metabolic process;heme oxidation;metabolic process;nitrogen compound metabolic process;porphyrin metabolic process;response to chemical stimulus;response to hypoxia;response to stress;tetrapyrrole metabolic process Porphyrin and chlorophyll metabolism 10 10 10 33.2 33.2 33.2 41.669 3.6225E-222 400840000 212400000 188450000 2003 IPI:IPI00026824.2 Heme oxygenase 2 HMOX2;HO2 P30519 ENST00000219700;ENST00000398595;ENST00000406590 K00510 1 0.73691 1.251 0.68752 0.97987 0.84792 0.90992 DS cell part;cytoplasmic part;cytosol;intracellular part binding;catalytic activity;deoxyhypusine synthase activity;protein binding;transferase activity;transferase activity, transferring alkyl or aryl (other than methyl) groups biogenic amine metabolic process;cellular amino acid and derivative metabolic process;cellular amino acid derivative metabolic process;polyamine catabolic process;polyamine metabolic process;protein modification process;translation 11 11 11 45 45 45 40.97 0 337390000 183990000 153400000 2004 IPI:IPI00026829.1;IPI:IPI00215771.1 Deoxyhypusine synthase DHPS;DS P49366-1;P49366;P49366-2 ENST00000210060;ENST00000351660 K00809 2 0.6742 1.2393 0.64655 0.86349 0.817 0.86589 Adenylsucc_synt cell part;cytoplasm;intracellular part adenylosuccinate synthase activity;binding;catalytic activity;GTP binding;guanyl nucleotide binding;ligase activity;ligase activity, forming carbon-nitrogen bonds;magnesium ion binding;nucleotide binding;purine nucleotide binding;ribonucleotide binding AMP biosynthetic process;immune system process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process Alanine and aspartate metabolism;Purine metabolism 20 20 20 50.7 50.7 50.7 50.097 0 900800000 482720000 418080000 2005 IPI:IPI00026833.4;IPI:IPI00167065.3;IPI:IPI00170914.1 Adenylosuccinate synthetase isozyme 2;Adenylosuccinate synthetase, acidic isozyme;IMP--aspartate ligase 2 ADSS;ADSS2 P30520 ENST00000366535 K01939 3 0.57434 1.2541 0.61607 0.74807 0.82131 0.859 Alpha-2-MRAP_C;Alpha-2-MRAP_N cell surface;cytoplasmic part;endoplasmic reticulum;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane;membrane part;membrane-bounded organelle;organelle;plasma membrane asialoglycoprotein receptor activity;binding;calcium ion binding;glycosaminoglycan binding;pattern binding;protein binding;receptor activity;receptor binding;receptor signaling protein activity;signal transducer activity;transmembrane receptor activity cell proliferation;cellular process;metabolic process;negative regulation of very-low-density lipoprotein particle clearance;protein folding;regulation of very-low-density lipoprotein particle clearance;transport 8 8 8 25.5 25.5 25.5 41.465 7.5151E-17 168670000 54903000 113770000 2006 IPI:IPI00026848.3 Alpha-2-macroglobulin receptor-associated protein;Low density lipoprotein receptor-related protein-associated protein 1 LRPAP1;A2MRAP P30533 ENST00000296325 1 0.76574 1.6114 0.77045 1.0061 1.0609 0.97847 SH2;SH3_1 cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;molecular adaptor activity;molecular transducer activity;protein binding;protein binding, bridging;SH3/SH2 adaptor activity;signal transducer activity cell communication;cell-cell signaling;cellular process;intracellular signaling cascade;Ras protein signal transduction;regulation of biological process;regulation of cellular process;signal transduction;small GTPase mediated signal transduction T cell receptor signaling pathway 14 14 14 48.8 48.8 48.8 37.909 4.4718E-117 302470000 163280000 139190000 2007 IPI:IPI00026928.3 GRB2-related adapter protein 2;Protein GADS;Growth factor receptor-binding protein;GRBLG;Grf40 adapter protein;GRB-2-like protein;GRBX;P38;Hematopoietic cell-associated adapter protein GrpL;Adapter protein GRID;SH3-SH2-SH3 adapter Mona GRAP2;GADS;GRB2L;GRID O75791 ENST00000344138;ENST00000407075 K07366 1 0.78353 1.4587 0.7963 1.0347 0.96387 1.0582 NUP50;Ran_BP1 cell part;intracellular organelle part;intracellular part;macromolecular complex;membrane;membrane part;nuclear membrane;nuclear part;nuclear pore;nucleoplasm;organelle membrane;organelle part;pore complex;protein complex binding;protein binding cellular process;establishment of protein localization;intracellular protein transport;intracellular transport;mRNA transport;nucleic acid transport;nucleobase, nucleoside, nucleotide and nucleic acid transport;protein transport;RNA transport;transport 11 11 11 32.7 32.7 32.7 50.144 2.096E-231 570670000 280290000 290370000 2008 IPI:IPI00026940.2 Nucleoporin 50 kDa;Nuclear pore-associated protein 60 kDa-like NUP50;NPAP60L;PRO1146 Q9UKX7 ENST00000347635 1 0.77651 1.6741 0.74106 1.0344 1.0798 1.0069 Band_7 cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part;plasma membrane 6 6 4 18 18 14.5 37.839 5.0757E-50 76017000 41108000 34909000 2009 IPI:IPI00026942.5;IPI:IPI00384365.2;IPI:IPI00386655.1 Erlin-2;Endoplasmic reticulum lipid raft-associated protein 2;Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2 ERLIN2;C8orf2;SPFH2;UNQ2441/PRO5003/PRO9924 O94905-1;O94905 ENST00000276461;ENST00000335171;ENST00000397228 3 0.763 1.4497 0.79863 0.97312 0.97759 0.96638 Pyr_redox_2 cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part binding;catalytic activity;electron carrier activity;ferredoxin reductase activity;ferredoxin-NADP+ reductase activity;oxidoreductase activity;oxidoreductase activity, acting on iron-sulfur proteins as donors;protein binding alcohol metabolic process;cholesterol metabolic process;generation of precursor metabolites and energy;lipid biosynthetic process;lipid metabolic process;metabolic process;steroid biosynthetic process;steroid metabolic process;transport 5 5 5 10.8 10.8 10.8 53.836 2.0272E-26 53123000 26308000 26815000 2010 IPI:IPI00026958.4;IPI:IPI00221118.2 NADPH:adrenodoxin oxidoreductase, mitochondrial;Ferredoxin--NADP(+) reductase FDXR;ADXR P22570-1;P22570;P22570-2 ENST00000293195 K00528 2 0.76467 1.3629 0.74153 0.96167 0.97449 0.93785 Rieske;Ubiq-Cytc-red_N;UCR_TM cytoplasmic part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;macromolecular complex;membrane part;mitochondrial part;mitochondrial respiratory chain complex III;organelle part;protein complex binding;catalytic activity;cation transmembrane transporter activity;electron carrier activity;ion transmembrane transporter activity;iron ion binding;transporter activity;ubiquinol-cytochrome-c reductase activity cellular metabolic process;cellular process;electron transport chain;establishment of localization;generation of precursor metabolites and energy;metabolic process;oxidation reduction;transport Alzheimer's disease;Cardiac muscle contraction;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 8 8 8 33.2 33.2 33.2 29.668 1.9219E-197 224490000 117570000 106910000 2011 IPI:IPI00026964.2;IPI:IPI00889196.2 Cytochrome b-c1 complex subunit Rieske, mitochondrial;Ubiquinol-cytochrome c reductase iron-sulfur subunit;Rieske iron-sulfur protein;Complex III subunit 5;Cytochrome b-c1 complex subunit 11;Ubiquinol-cytochrome c reductase 8 kDa protein;Complex III subunit IX;Cytochrome b-c1 complex subunit Rieske-like protein 1 UQCRFS1;UQCRFSL1 P47985;P0C7P4 ENST00000304863 K00411 2 0.81652 1.1897 0.78653 1.0996 0.79323 1.0215 UQ_con acid-amino acid ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;ubiquitin-protein ligase activity cell communication;cell surface receptor linked signal transduction;enzyme linked receptor protein signaling pathway;protein modification process;proteolysis;signal transduction;ubiquitin-dependent protein catabolic process Ubiquitin mediated proteolysis 2 2 2 14.2 14.2 14.2 16.785 2.9095E-10 445810000 237650000 208160000 2012 IPI:IPI00749013.2;IPI:IPI00026965.1;IPI:IPI00375142.2;IPI:IPI00332376.4 Ubiquitin-conjugating enzyme E2 D3;Ubiquitin-protein ligase D3;Ubiquitin carrier protein D3;Ubiquitin-conjugating enzyme E2-17 kDa 3;E2(17)KB 3;Ubiquitin-conjugating enzyme E2 D2;Ubiquitin-protein ligase D2;Ubiquitin carrier protein D2;Ubiquitin-conjugating enzyme E2-17 kDa 2;E2(17)KB 2 UBE2D3;UBCH5C;UBE2D2;UBC4;UBCH5B P61077-2;P61077;P61077-1;P61077-3;P62837 ENST00000321805;ENST00000338145;ENST00000349311;ENST00000350435;ENST00000394801;ENST00000394803;ENST00000394804;ENST00000253815;ENST00000398734 K06689 4 0.76357 1.4123 0.66996 0.97621 0.92587 0.87488 DDHD;SAM_1 coated vesicle membrane;cytoplasmic vesicle membrane;endoplasmic reticulum;ER to Golgi transport vesicle membrane;ER-Golgi intermediate compartment;Golgi membrane;Golgi-associated vesicle membrane;membrane;transport vesicle membrane;vesicle membrane binding;cation binding;ion binding;metal ion binding;protein binding cellular component organization;cellular process;establishment of localization;establishment of protein localization;Golgi organization;intracellular protein transport;intracellular transport;organelle organization;protein transport;transport 10 10 10 12.2 12.2 12.2 111.08 7.5822E-147 90198000 48654000 41544000 2013 IPI:IPI00026969.4;IPI:IPI00473012.1 SEC23-interacting protein;p125 SEC23IP;MSTP053 Q9Y6Y8-1;Q9Y6Y8;Q9Y6Y8-2 ENST00000369075 2 0.67487 1.2704 0.67614 0.90563 0.85766 0.86511 Peptidase_M24;Rtt106;SPT16 cell part;chromosome;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleoplasm;organelle;organelle part positive transcription elongation factor activity;transcription elongation regulator activity;transcription regulator activity chromatin organization;DNA metabolic process;DNA repair;DNA replication;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleosome disassembly;regulation of transcription, DNA-dependent;transcription;transcription, DNA-dependent 42 42 42 40 40 40 119.91 0 2701300000 1441600000 1259700000 2014 IPI:IPI00026970.4 FACT complex subunit SPT16;Facilitates chromatin transcription complex subunit SPT16;FACT 140 kDa subunit;FACTp140;Chromatin-specific transcription elongation factor 140 kDa subunit SUPT16H;FACT140;FACTP140 Q9Y5B9 ENST00000216297 1 0.80565 1.3007 0.81898 1.0192 0.90702 1.0591 zf-C3HC4 cell part;chromosome;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle binding;catalytic activity;cation binding;ion binding;ligase activity;metal ion binding;protein binding;transition metal ion binding;zinc ion binding catabolic process;macromolecule catabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;proteolysis;regulation of transcription, DNA-dependent;transcription 7 7 5 22 22 17.6 37.655 9.1966E-71 78360000 40291000 38070000 2015 IPI:IPI00026993.1 E3 ubiquitin-protein ligase RING2;RING finger protein 2;RING finger protein 1B;RING finger protein BAP-1;DinG protein;Huntingtin-interacting protein 2-interacting protein 3 RNF2;BAP1;DING;HIPI3;RING1B Q99496 ENST00000367510 K10695 1 0.87678 1.5819 1.1636 1.0835 1.1069 1.4394 PRA1 cell part;cytoplasmic part;endosomal part;endosome membrane;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part acidic amino acid transport;amine transport;amino acid transport;carboxylic acid transport;cellular process;establishment of localization;establishment of protein localization;L-glutamate transport;organic acid transport;protein transport;transport 3 3 3 23 23 23 19.258 1.6811E-65 171960000 81020000 90944000 2016 IPI:IPI00026994.3 PRA1 family protein 2 PRAF2;JM4 O60831 ENST00000376390 1 0.7835 1.4527 0.80002 1.0554 0.96414 1.0596 FCH;SH3_1 cell part;cytoplasmic part;cytoplasmic vesicle;intracellular organelle;intracellular part;organelle;vesicle transporter activity actin cytoskeleton organization;actin filament-based process;cellular component organization;cellular process;cytoskeleton organization;endocytosis;membrane invagination;membrane organization;organelle organization;transport;vesicle-mediated transport 10 10 10 22.4 22.4 22.4 55.738 1.009E-78 257250000 135050000 122200000 2017 IPI:IPI00027009.2;IPI:IPI00221111.1 Protein kinase C and casein kinase substrate in neurons protein 2 PACSIN2 Q9UNF0-1;Q9UNF0;Q9UNF0-2 ENST00000263246;ENST00000337959;ENST00000402229;ENST00000403744 2 0.87815 1.6146 0.86732 1.1291 1.0592 1.0985 Dynactin_p22 centrosome;condensed chromosome kinetochore;dynactin complex;intracellular organelle;kinetochore;macromolecular complex;microtubule associated complex;microtubule organizing center;non-membrane-bounded organelle;organelle;spindle binding;protein binding;structural molecule activity cell cycle phase;cell cycle process;cell division;cellular component organization;cellular process;cytokinesis;mitosis;nuclear division;organelle fission;organelle organization 7 7 7 38.2 38.2 38.2 21.119 1.7202E-43 159520000 87224000 72297000 2018 IPI:IPI00027014.1;IPI:IPI00514971.2;IPI:IPI00013654.1;IPI:REV_IPI00220308.1;IPI:REV_IPI00414431.2;IPI:REV_IPI00304755.2;IPI:REV_IPI00220314.1;IPI:REV_IPI00220311.1;IPI:REV_IPI00220312.1;IPI:REV_IPI00220310.1;IPI:REV_IPI00414202.2;IPI:REV_IPI00216128.1;IPI:REV_IPI00220315.1 Dynactin subunit 3;Dynactin complex subunit 22 kDa subunit DCTN3;DCTN22 O75935-1;O75935;O75935-3;O75935-2 ENST00000259632;ENST00000341694;ENST00000378911;ENST00000378916 K10425 13 0.4947 0.93947 NaN 0.65969 0.59286 NaN Retrotrans_gag cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;protein binding 3 2 2 5.5 3.8 3.8 41.509 0.0014066 3896000 2456600 1439400 2021 IPI:IPI00027028.1 Paraneoplastic antigen Ma2;Onconeuronal antigen Ma2;Paraneoplastic neuronal antigen MM2;40 kDa neuronal protein PNMA2;KIAA0883;MA2 Q9UL42 ENST00000305426 1 0.83463 1.6603 0.77402 1.0597 1.1153 0.98148 Abhydrolase_2 cell part;cytoplasm;intracellular part catalytic activity;hydrolase activity carboxylic acid metabolic process;cellular ketone metabolic process;cellular process;fatty acid metabolic process;lipid metabolic process;metabolic process;monocarboxylic acid metabolic process;organic acid metabolic process;oxoacid metabolic process Glycerophospholipid metabolism 4 4 4 30.3 30.3 30.3 24.737 3.3723E-153 135370000 73585000 61790000 2022 IPI:IPI00027032.1 Acyl-protein thioesterase 2;Lysophospholipase II LYPLA2 O95372 ENST00000374514 K06130 1 0.75713 1.686 0.9977 0.99592 1.1148 1.3205 SGT1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding;transcription regulator activity nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of carbohydrate metabolic process;regulation of glycolysis;regulation of transcription, DNA-dependent;transcription;transcription, DNA-dependent 7 7 7 12.7 12.7 12.7 72.757 1.2898E-15 19789000 11297000 8491800 2023 IPI:IPI00027034.1 Protein SGT1;Protein ecdysoneless homolog;Suppressor of GCR2 ECD;SGT1 O95905 ENST00000372979 1 0.80756 1.3047 0.752 1.0334 0.90889 0.967 Peptidase_M14 cell fraction;cell part;insoluble fraction;integral to membrane;intrinsic to membrane;membrane fraction;membrane part binding;carboxypeptidase activity;catalytic activity;exopeptidase activity;metallocarboxypeptidase activity;metalloexopeptidase activity;metallopeptidase activity;peptidase activity;serine-type carboxypeptidase activity;serine-type peptidase activity biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis 7 7 7 5.8 5.8 5.8 152.93 1.4803E-96 17795000 9688700 8106100 2024 IPI:IPI00027078.3 Carboxypeptidase D;Metallocarboxypeptidase D;gp180 CPD O75976 ENST00000225719 K07752 1 0.77251 1.3304 0.77149 0.95775 0.92307 0.97065 intracellular membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane;membrane-bounded organelle;mitochondrion;non-membrane-bounded organelle;nuclear membrane;organelle;organelle membrane;ribonucleoprotein complex;ribosome structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 6 6 6 24.3 24.3 24.3 33.535 1.5676E-20 123420000 68185000 55233000 2025 IPI:IPI00027096.2 39S ribosomal protein L19, mitochondrial;MRP-L15 MRPL19;KIAA0104;MRPL15 P49406 ENST00000393909;ENST00000409374 1 0.72855 1.4921 0.72835 0.96195 0.98745 0.95682 GTP_EFTU;GTP_EFTU_D2;GTP_EFTU_D3 cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial nucleoid;mitochondrial part;nucleoid;organelle part binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;nucleic acid binding;nucleotide binding;protein binding;pyrophosphatase activity;translation elongation factor activity;translation factor activity, nucleic acid binding biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation 29 29 29 58.5 58.5 58.5 49.874 0 4815000000 2593900000 2221100000 2026 IPI:IPI00027107.5 Elongation factor Tu, mitochondrial;P43 TUFM P49411 ENST00000313511 K02358 1 0.71509 1.8497 NaN 0.96065 1.2333 NaN UQ_con cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle acid-amino acid ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;ubiquitin-protein ligase activity DNA metabolic process;DNA replication initiation;G1/S transition of mitotic cell cycle;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein modification process;proteolysis Ubiquitin mediated proteolysis 4 3 3 16.5 13.1 13.1 26.736 3.7896E-13 3294600 1875900 1418700 2027 IPI:IPI00027120.1 Ubiquitin-conjugating enzyme E2 R1;Ubiquitin-protein ligase R1;Ubiquitin-conjugating enzyme E2-32 kDa complementing;E2-CDC34 CDC34;UBE2R1 P49427 ENST00000215574 K02207 1 0.45171 1.2445 NaN 0.62372 0.77474 NaN Alba cell part;intracellular organelle part;intracellular part;macromolecular complex;multimeric ribonuclease P complex;nuclear part;nucleolar part;nucleolar ribonuclease P complex;organelle part;ribonuclease P complex;ribonucleoprotein complex binding;catalytic activity;endonuclease activity;endoribonuclease activity;hydrolase activity;nuclease activity;nucleic acid binding;protein binding;ribonuclease activity;ribonuclease P activity;tRNA-specific ribonuclease activity cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;tRNA metabolic process;tRNA processing 3 3 3 32.1 32.1 32.1 15.651 5.5052E-49 27528000 15117000 12411000 2028 IPI:IPI00027142.2 Ribonuclease P protein subunit p20 POP7;RPP20 O75817 ENST00000303151 K01164 1 NaN 1.5723 0.77756 NaN 1.0541 0.99452 PK;PK_C ATP binding;binding;catalytic activity;kinase activity;magnesium ion binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyruvate kinase activity;transferase activity;transferase activity, transferring phosphorus-containing groups alcohol metabolic process;carbohydrate metabolic process;catabolic process;cellular process;generation of precursor metabolites and energy;glucose catabolic process;glucose metabolic process;glycolysis;metabolic process;monosaccharide metabolic process Glycolysis / Gluconeogenesis;Insulin signaling pathway;Maturity onset diabetes of the young;Purine metabolism;Pyruvate metabolism;Type II diabetes mellitus 4 1 1 5.2 2.3 2.3 61.829 1.9996E-12 23316000 12491000 10825000 2030 IPI:IPI00027165.3;IPI:IPI00941093.1 Pyruvate kinase isozymes R/L;R-type/L-type pyruvate kinase;Red cell/liver pyruvate kinase;Pyruvate kinase 1 PKLR;PK1;PKL P30613-1;P30613;P30613-2 ENST00000271946;ENST00000342741;ENST00000392414 K12406 2 0.85617 1.5989 0.97098 1.121 1.0794 1.2187 efhand cell part;cytoplasm;intracellular part auxiliary transport protein activity;binding;calcium channel regulator activity;calcium ion binding;cation binding;channel regulator activity;ion binding;metal ion binding;protein binding;receptor binding cell communication;cellular ion homeostasis;heart development;intracellular sequestering of iron ion;regulation of action potential;regulation of muscle contraction;regulation of striated muscle contraction;signal transduction;transport 13 13 13 67.2 67.2 67.2 21.676 4.528E-171 1700100000 869290000 830800000 2031 IPI:IPI00027175.1 Sorcin;22 kDa protein;CP-22;V19 SRI P30626 ENST00000265729;ENST00000394641 1 NaN 0.85167 NaN NaN 0.60671 NaN Adaptin_N;Alpha_adaptinC2 AP-1 adaptor complex;AP-type membrane coat adaptor complex;clathrin adaptor complex;endosome membrane;Golgi apparatus part;intracellular part;macromolecular complex;membrane;membrane part;organelle membrane;organelle part;plasma membrane;protein complex binding;protein binding;protein transporter activity;substrate-specific transporter activity;transporter activity cellular process;establishment of localization;establishment of protein localization;interspecies interaction between organisms;intracellular protein transport;intracellular transport;protein transport;transport;vesicle-mediated transport 2 2 2 2.4 2.4 2.4 87.116 9.1528E-06 2774300 1415600 1358700 2032 IPI:IPI00027178.1 AP-1 complex subunit gamma-like 2;Gamma2-adaptin AP1G2 O75843 ENST00000308724;ENST00000397120 1 0.79769 1.7936 0.73236 1.1061 1.1108 1.0759 Peptidase_M48 cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;Golgi apparatus part;Golgi membrane;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part binding;catalytic activity;cation binding;endopeptidase activity;exopeptidase activity;hydrolase activity;ion binding;metalloendopeptidase activity;metalloexopeptidase activity;metallopeptidase activity;peptidase activity;zinc ion binding biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis 7 7 7 18.5 18.5 18.5 54.812 1.1736E-43 69181000 36355000 32826000 2033 IPI:IPI00027180.1 CAAX prenyl protease 1 homolog;Prenyl protein-specific endoprotease 1;Farnesylated proteins-converting enzyme 1;Zinc metalloproteinase Ste24 homolog ZMPSTE24;FACE1;STE24 O75844 ENST00000372759 K06013 1 0.83249 1.6179 0.82203 1.0762 1.0595 1.0993 Syntaxin-18_N cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;Golgi apparatus part;Golgi membrane;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part binding;protein binding;SNAP receptor activity cellular process;ER to Golgi vesicle-mediated transport;establishment of protein localization;Golgi vesicle transport;intracellular protein transport;intracellular transport;protein transport;transport;vesicle-mediated transport SNARE interactions in vesicular transport 8 8 8 25.1 25.1 25.1 38.673 1.2694E-38 105120000 54877000 50245000 2034 IPI:IPI00027194.1 Syntaxin-18;Cell growth-inhibiting gene 9 protein STX18;GIG9 Q9P2W9 ENST00000306200 K08492 1 0.78573 1.6647 0.73961 1.0669 1.0779 1.003 Iso_dh cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;microbody;organelle;peroxisome binding;catalytic activity;isocitrate dehydrogenase (NADP+) activity;isocitrate dehydrogenase activity;magnesium ion binding;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors acetyl-CoA metabolic process;carbohydrate metabolic process;cellular aldehyde metabolic process;coenzyme metabolic process;glyoxylate cycle;isocitrate metabolic process;metabolic process;organic acid metabolic process;tricarboxylic acid cycle Citrate cycle (TCA cycle);Glutathione metabolism;Reductive carboxylate cycle (CO2 fixation) 16 15 15 40.8 38.6 38.6 46.659 2.426E-201 339250000 196930000 142320000 2035 IPI:IPI00027223.2 Isocitrate dehydrogenase [NADP] cytoplasmic;Cytosolic NADP-isocitrate dehydrogenase;Oxalosuccinate decarboxylase;NADP(+)-specific ICDH;IDP IDH1;PICD O75874 ENST00000345146 K00031 1 0.85145 1.2503 0.9181 1.0709 0.88473 1.1549 GatB;GatB_N;GatB_Yqey cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;translation factor activity, nucleic acid binding biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 4 4 4 8.1 8.1 8.1 61.863 3.5648E-31 96434000 49304000 47129000 2036 IPI:IPI00027228.1 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial;Cytochrome oxidase assembly factor PET112 homolog PET112L;PET112;HSPC199 O75879 ENST00000263985 1 1.2854 2.5109 1.2843 1.7006 1.6565 1.7028 HATPase_c;HSP90 cell fraction;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;cytosol;endoplasmic reticulum lumen;endoplasmic reticulum membrane;insoluble fraction;membrane;membrane fraction;membrane-enclosed lumen;microsome;organelle membrane;vesicle adenyl nucleotide binding;ATP binding;binding;calcium ion binding;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;receptor binding;ribonucleotide binding;RNA binding anti-apoptosis;cellular biopolymer metabolic process;cellular process;metabolic process;protein folding;protein metabolic process;protein transport;regulation of cell death;response to chemical stimulus;response to hypoxia;response to stress;transport Pathways in cancer;Prostate cancer 47 44 44 51.3 49.6 49.6 92.468 0 10338000000 4883700000 5454200000 2037 IPI:IPI00027230.3;IPI:IPI00556538.1 Endoplasmin;Heat shock protein 90 kDa beta member 1;94 kDa glucose-regulated protein;gp96 homolog;Tumor rejection antigen 1 HSP90B1;TRA1 P14625 ENST00000299767 K09487 2 0.74315 1.2685 0.74666 0.99371 0.86394 0.96396 SCO1-SenC cell part;cytoplasmic part;intracellular organelle part;intracellular part;membrane;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part binding;cation binding;copper ion binding;ion binding;metal ion binding;transition metal ion binding cation transport;cellular copper ion homeostasis;cellular ion homeostasis;copper ion transport;generation of precursor metabolites and energy;ion transport;metabolic process;protein complex assembly;transition metal ion transport;transport 4 4 4 16.3 16.3 16.3 33.814 3.3633E-25 184290000 91758000 92536000 2038 IPI:IPI00027233.3 Protein SCO1 homolog, mitochondrial SCO1;SCOD1 O75880 ENST00000255390 K07152 1 0.37104 0.78747 0.48477 0.5059 0.50245 0.62297 Pkinase;Pkinase_C cell part;cytoplasm;histone methyltransferase complex;intracellular organelle part;intracellular part;macromolecular complex;methyltransferase complex;nuclear part;nucleoplasm part;organelle part;protein complex ATP binding;binding;catalytic activity;kinase activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cell communication;cellular process;intracellular signaling cascade;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein kinase cascade;protein modification process;signal transduction 12 12 10 31.8 31.8 27.7 54.19 2.9855E-54 58701000 32808000 25893000 2040 IPI:IPI00027251.1 Serine/threonine-protein kinase 38;NDR1 protein kinase;Nuclear Dbf2-related kinase 1 STK38;NDR1 Q15208 ENST00000229812;ENST00000407753 K08790 1 0.7655 1.4348 0.7703 0.96098 0.99757 0.95002 Band_7 intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;mitochondrial inner membrane;mitochondrial membrane;nucleus;organelle;organelle inner membrane;organelle membrane;organelle part binding;estrogen receptor binding;nuclear hormone receptor binding;protein binding;receptor activity;receptor binding;signal transducer activity;specific transcriptional repressor activity;transcription regulator activity;transcription repressor activity biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 18 18 18 62.2 62.2 62.2 33.296 0 2556400000 1351000000 1205500000 2041 IPI:IPI00027252.6 Prohibitin-2;B-cell receptor-associated protein BAP37;Repressor of estrogen receptor activity;D-prohibitin PHB2;BAP;REA Q99623 ENST00000399433 1 0.92759 1.6606 NaN 1.3721 1.0068 NaN MAP1_LC3 autophagic vacuole membrane;cytoplasmic part;cytoskeletal part;Golgi apparatus part;Golgi membrane;intracellular organelle part;intracellular part;membrane;microtubule;organelle membrane;organelle part;plasma membrane;vacuolar membrane;vacuolar part beta-tubulin binding;binding;cytoskeletal protein binding;GABA receptor binding;protein binding;receptor binding;tubulin binding cell communication;cell-cell signaling;cellular process;establishment of localization;establishment of protein localization;intracellular protein transport;intracellular transport;protein targeting;protein transport;synaptic transmission;transport Regulation of autophagy 2 1 1 18.8 9.4 9.4 13.918 1.5138E-08 100950000 49889000 51057000 2042 IPI:IPI00027253.3;IPI:IPI00027733.1 Gamma-aminobutyric acid receptor-associated protein;GABA(A) receptor-associated protein;MM46;Gamma-aminobutyric acid receptor-associated protein-like 1;GABA(A) receptor-associated protein-like 1;Glandular epithelial cell protein 1;Early estrogen-regulated protein GABARAP;FLC3B;HT004;GABARAPL1;GEC1 O95166;Q9H0R8 ENST00000302386;ENST00000266458 K08341 2 0.93773 1.7247 0.84875 1.262 1.0916 1.1152 Cbl_N;Cbl_N2;Cbl_N3;UBA;zf-C3HC4 cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;calcium ion binding;catalytic activity;DNA binding;ligase activity;nucleic acid binding;protein binding;signal transducer activity;transcription factor activity;ubiquitin-protein ligase activity;zinc ion binding cell communication;cell surface receptor linked signal transduction;enzyme linked receptor protein signaling pathway;protein modification process;proteolysis;signal transduction;transmembrane receptor protein tyrosine kinase signaling pathway Chronic myeloid leukemia;ErbB signaling pathway;Insulin signaling pathway;Jak-STAT signaling pathway;Pathways in cancer;T cell receptor signaling pathway;Ubiquitin mediated proteolysis 11 11 11 17.7 17.7 17.7 99.632 9.8412E-81 177200000 89478000 87723000 2044 IPI:IPI00027269.2;IPI:IPI00292856.4;IPI:IPI00382825.3;IPI:IPI00914020.1 E3 ubiquitin-protein ligase CBL;Signal transduction protein CBL;Proto-oncogene c-CBL;Casitas B-lineage lymphoma proto-oncogene;RING finger protein 55 CBL;CBL2;RNF55 P22681 ENST00000264033 K04707 4 0.73725 1.3377 0.69687 0.95379 0.89201 0.93752 KOW cell part;cytoplasmic part;cytosolic large ribosomal subunit;cytosolic part;intracellular organelle part;intracellular part;large ribosomal subunit;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit binding;nucleic acid binding;protein binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA processing;rRNA processing;translational elongation Ribosome 10 10 2 46.9 46.9 13.8 17.258 1.2446E-74 3580600000 1872500000 1708000000 2045 IPI:IPI00027270.1 60S ribosomal protein L26 RPL26 P61254 ENST00000293842;ENST00000334048 K02898 1 0.684 1.2733 0.61946 0.91111 0.82685 0.78642 DNA_gyraseB;DNA_topoisoIV;DTHCT;HATPase_c cell part;chromosome;cytoplasmic part;cytosol;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;nucleoplasm;organelle;organelle part binding;catalytic activity;chromatin binding;DNA binding;DNA topoisomerase (ATP-hydrolyzing) activity;DNA topoisomerase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;protein kinase C binding;purine nucleoside binding cellular biopolymer metabolic process;cellular process;DNA metabolic process;DNA topological change;macromolecule metabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 29 18 18 20.3 13.5 13.5 183.26 0 174980000 94266000 80712000 2046 IPI:IPI00027280.2;IPI:IPI00217709.1 DNA topoisomerase 2-beta;DNA topoisomerase II, beta isozyme TOP2B Q02880-1;Q02880;Q02880-2 ENST00000264331 K03164 2 0.82261 1.3619 0.78975 1.0253 0.9321 0.98532 LSM cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;ribonucleoprotein complex;small nuclear ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;protein binding;RNA binding cellular component biogenesis;cellular process;ribonucleoprotein complex biogenesis;spliceosomal snRNP biogenesis Systemic lupus erythematosus 10 10 1 33.9 33.9 4.8 30.032 2.8047E-205 2343700000 1243500000 1100200000 2047 IPI:IPI00329512.3;IPI:IPI00027285.1;IPI:IPI00395674.1 Small nuclear ribonucleoprotein-associated proteins B and B';Sm-B/Sm-B' SNRPB;COD;SNRPB1 P14678-3;P14678;P14678-1;P14678-2 ENST00000303103;ENST00000336808;ENST00000381342 K11086 3 0.83825 1.5504 0.84112 1.0675 1.0514 1.0775 Gelsolin cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;F-actin capping protein complex;intracellular organelle;macromolecular complex;melanosome;membrane-bounded organelle;membrane-bounded vesicle;nucleus;organelle;vesicle actin binding;binding;cytoskeletal protein binding;protein binding anatomical structure formation;negative regulation of macromolecule metabolic process;negative regulation of metabolic process;negative regulation of organelle organization;protein complex assembly;regulation of actin polymerization or depolymerization 16 16 16 48.6 48.6 48.6 38.517 1.9364E-290 3802600000 1994200000 1808400000 2048 IPI:IPI00027341.1 Macrophage-capping protein;Actin regulatory protein CAP-G CAPG;AFCP;MCP P40121 ENST00000263867;ENST00000409670;ENST00000409724 1 0.77131 1.6614 0.77749 1.0144 1.0933 1.053 1-cysPrx_C;AhpC-TSA cell part;cytoplasm;intracellular part antioxidant activity;catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on peroxide as acceptor;peroxidase activity;peroxiredoxin activity;thioredoxin peroxidase activity anti-apoptosis;cellular homeostasis;cellular process;homeostatic process;metabolic process;negative regulation of apoptosis;regulation of apoptosis;regulation of cell death;response to chemical stimulus;response to oxidative stress;response to stress 16 15 15 58.1 52.5 52.5 21.892 0 3885800000 2090400000 1795300000 2049 IPI:IPI00027350.3 Peroxiredoxin-2;Thioredoxin peroxidase 1;Thioredoxin-dependent peroxide reductase 1;Thiol-specific antioxidant protein;PRP;Natural killer cell-enhancing factor B PRDX2;NKEFB;TDPX1 P32119 ENST00000301522 K03386 1 0.88721 1.4171 0.90078 1.1138 1.0113 1.1254 UBA;UBX cell part;cytoplasm;intracellular part ATPase binding;binding;enzyme binding;polyubiquitin binding;protein binding;small conjugating protein binding;ubiquitin binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process 8 8 8 30 30 30 33.325 5.3296E-110 323500000 133020000 190480000 2050 IPI:IPI00027378.5;IPI:IPI00396563.2 UBX domain-containing protein 1;SAPK substrate protein 1;UBA/UBX 33.3 kDa protein UBXN1;SAKS1 Q04323-1;Q04323;Q04323-2 ENST00000294119;ENST00000301935 2 0.57038 1.1853 0.66401 0.73768 0.76504 0.88718 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 7 7 7 56.8 56.8 56.8 20.063 1.4455E-113 290900000 156490000 134400000 2052 IPI:IPI00027397.3;IPI:IPI00607884.1 Hematological and neurological expressed 1-like protein HN1L;C16orf34;L11 Q9H910-1;Q9H910;Q9H910-2 ENST00000248098 2 0.59373 0.9751 0.61876 0.79117 0.64174 0.75408 DEAD;DUF1605;HA2;Helicase_C cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;ATP-dependent helicase activity;binding;catalytic activity;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity 18 18 18 22.3 22.3 22.3 114.77 3.8596E-137 313210000 168080000 145120000 2053 IPI:IPI00027415.2;IPI:IPI00784170.1;IPI:IPI00217760.2 Probable ATP-dependent RNA helicase DHX36;DEAH box protein 36;MLE-like protein 1;RNA helicase associated with AU-rich element ARE DHX36;DDX36;KIAA1488;MLEL1;RHAU Q9H2U1-1;Q9H2U1;Q9H2U1-2;Q9H2U1-3 ENST00000308361;ENST00000329463;ENST00000392856 3 0.71825 1.3419 0.60126 0.96914 0.88013 0.79931 FGGY_C;FGGY_N cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;membrane;mitochondrial membrane;mitochondrial outer membrane;mitochondrial part;organelle membrane;organelle outer membrane;organelle part;outer membrane ATP binding;binding;catalytic activity;glycerol kinase activity;kinase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups alcohol metabolic process;alditol metabolic process;carbohydrate metabolic process;cellular process;glycerol metabolic process;glycerol-3-phosphate metabolic process;metabolic process;phosphate metabolic process;phosphorus metabolic process Glycerolipid metabolism;PPAR signaling pathway 4 4 4 9.5 9.5 9.5 61.244 1.3017E-30 24029000 13847000 10182000 2054 IPI:IPI00216067.1;IPI:IPI00216066.1;IPI:IPI00030811.2;IPI:IPI00027424.3;IPI:IPI00419234.4 Glycerol kinase;ATP:glycerol 3-phosphotransferase;Glycerokinase;Putative glycerol kinase 3;Glycerol kinase, testis specific 1;Glycerol kinase 2;Glycerol kinase, testis specific 2 GK;GK3P;GKP3;GKTB;GK2;GKP2;GKTA P32189-3;P32189;P32189-2;Q14409;P32189-1;Q14410 ENST00000378943;ENST00000378945;ENST00000378948;ENST00000397531;ENST00000358842 K00864 5 0.62279 1.2472 0.59805 0.81543 0.81569 0.80593 cell part;extracellular region part;extracellular space;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part bacterial binding;binding;molecular transducer activity;receptor activity;signal transducer activity;transmembrane receptor activity behavior;cellular defense response;chemotaxis;defense response;establishment or maintenance of cell polarity;immune response;immune system process;negative regulation of cell adhesion;regulation of cytokine production;response to stress Cell adhesion molecules (CAMs) 2 2 2 3 3 3 40.321 3.4543E-19 249510000 138750000 110760000 2055 IPI:IPI00027430.1 Leukosialin;Leukocyte sialoglycoprotein;Sialophorin;Galactoglycoprotein SPN;CD43 P16150 ENST00000360121;ENST00000395389 K06477 1 NaN 1.4031 0.86681 NaN 0.89898 1.1612 Ras cell part;intracellular;membrane;plasma membrane binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity;signal transducer activity cell communication;cellular process;intracellular signaling cascade;positive regulation of signal transduction;regulation of protein kinase cascade;regulation of signal transduction;signal transduction;small GTPase mediated signal transduction 8 1 1 56 6.2 6.2 22.006 3.4413E-157 119090000 61823000 57271000 2056 IPI:IPI00027434.1;IPI:IPI00000041.1 Rho-related GTP-binding protein RhoC;H9 RHOC;ARH9;ARHC P08134 ENST00000285735;ENST00000339083;ENST00000369632;ENST00000369633;ENST00000369636;ENST00000369637;ENST00000369638;ENST00000369642 K07857 2 0.99136 1.7239 0.90441 1.286 1.1793 1.1728 Band_7 centriolar satellite;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;Golgi apparatus;integral to membrane;intracellular organelle;intrinsic to membrane;melanosome;membrane-bounded organelle;membrane-bounded vesicle;organelle;vesicle binding;protein binding Insulin signaling pathway 11 11 11 28.6 28.6 28.6 47.355 4.8103E-157 174550000 87917000 86635000 2057 IPI:IPI00027438.2 Flotillin-1 FLOT1 O75955 ENST00000376389;ENST00000383382;ENST00000383562 K07192 1 0.85644 1.6684 0.90495 1.1442 1.0877 1.1838 DHHA1;tRNA_SAD;tRNA-synt_2c cell fraction;cell part;cytoplasm;intracellular part;soluble fraction alanine-tRNA ligase activity;aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;ligase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;RNA binding;tRNA binding alanyl-tRNA aminoacylation;cellular amino acid and derivative metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;tRNA aminoacylation for protein translation;tRNA metabolic process Alanine and aspartate metabolism;Aminoacyl-tRNA biosynthesis 40 40 40 52.4 52.4 52.4 106.81 0 3855300000 1991400000 1863900000 2058 IPI:IPI00027442.4 Alanyl-tRNA synthetase, cytoplasmic;Alanine--tRNA ligase;Renal carcinoma antigen NY-REN-42 AARS P49588 ENST00000261772 K01872 1 0.85595 1.5381 0.3936 1.0424 1.0693 0.61041 HGTP_anticodon;tRNA-synt_2b cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;histidine-tRNA ligase activity;ligase activity;ligase activity, forming carbon-oxygen bonds;nucleoside binding;nucleotide binding;purine nucleoside binding cellular amino acid and derivative metabolic process;histidyl-tRNA aminoacylation;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;tRNA aminoacylation for protein translation;tRNA metabolic process Aminoacyl-tRNA biosynthesis;Histidine metabolism 18 11 11 38.7 24.9 24.9 56.888 5.4839E-151 60479000 32500000 27978000 2059 IPI:IPI00027445.1 Probable histidyl-tRNA synthetase, mitochondrial;Histidine--tRNA ligase;Histidine--tRNA ligase-like HARS2;HARSL;HARSR;HO3 P49590 ENST00000230771 K01892 1 0.82446 1.6025 0.83695 0.98611 1.1179 0.98948 ATP-synt_G intracellular part;macromolecular complex;membrane part;mitochondrial proton-transporting ATP synthase complex, coupling factor F(o);organelle part;protein complex;proton-transporting two-sector ATPase complex, proton-transporting domain binding;cation transmembrane transporter activity;hydrogen ion transmembrane transporter activity;ion transmembrane transporter activity;monovalent inorganic cation transmembrane transporter activity;protein binding;transporter activity ATP biosynthetic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;transport Oxidative phosphorylation 4 4 4 38.8 38.8 38.8 11.428 4.9914E-12 629570000 334390000 295180000 2060 IPI:IPI00027448.3 ATP synthase subunit g, mitochondrial ATP5L O75964 ENST00000300688 K02140 1 0.020254 16.317 0.39994 0.026714 10.559 0.5841 efhand;S_100 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;calcium ion binding;cation binding;ion binding;metal ion binding;molecular transducer activity;protein binding;signal transducer activity cell communication;cell-cell signaling;cellular process;defense response;inflammatory response;response to external stimulus;response to stimulus;response to stress;response to wounding + 7 7 7 36 36 36 13.242 1.3588E-48 164270000 157090000 7179600 2061 IPI:IPI00027462.1 Protein S100-A9;S100 calcium-binding protein A9;Calgranulin-B;Migration inhibitory factor-related protein 14;Leukocyte L1 complex heavy chain;Calprotectin L1H subunit S100A9;CAGB;CFAG;MRP14 P06702 ENST00000368738 1 0.64239 1.7675 0.61902 0.93243 1.0558 0.89236 efhand calcineurin complex;cell part;cytoplasmic part;cytosol;intracellular part;macromolecular complex;protein complex;protein serine/threonine phosphatase complex binding;calcium ion binding;calcium-dependent protein serine/threonine phosphatase activity;calmodulin binding;catalytic activity;hydrolase activity;phosphoprotein phosphatase activity;protein binding;protein serine/threonine phosphatase activity activation of pro-apoptotic gene products;positive regulation of apoptosis;positive regulation of cell death;positive regulation of programmed cell death;regulation of apoptosis;regulation of cell death;regulation of programmed cell death Alzheimer's disease;Amyotrophic lateral sclerosis (ALS);Apoptosis;Axon guidance;B cell receptor signaling pathway;Calcium signaling pathway;Long-term potentiation;MAPK signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;VEGF signaling pathway;Wnt signaling pathway 2 2 2 10.6 10.6 10.6 19.3 4.3822E-34 18754000 10286000 8468200 2062 IPI:IPI00027464.8 Calcineurin subunit B type 1;Protein phosphatase 2B regulatory subunit 1;Protein phosphatase 3 regulatory subunit B alpha isoform 1 PPP3R1;CNA2;CNB P63098 ENST00000406334;ENST00000409752 K06268 1 0.69651 1.247 0.67162 0.89677 0.82434 0.87985 IF4E cell part;cytoplasmic part;cytosol;eukaryotic translation initiation factor 4F complex;intracellular part;macromolecular complex;protein complex binding;nucleic acid binding;protein binding;RNA binding;RNA cap binding;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity cellular process;posttranscriptional regulation of gene expression;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of translation;translational initiation 6 6 6 22.6 22.6 22.6 25.097 1.1868E-41 760540000 470730000 289810000 2063 IPI:IPI00027485.3;IPI:IPI00852709.1 Eukaryotic translation initiation factor 4E;mRNA cap-binding protein;eIF-4F 25 kDa subunit EIF4E;EIF4EL1;EIF4F P06730 ENST00000280892;ENST00000394918 2 0.91444 1.7929 0.96983 1.2037 1.1928 1.2645 Alpha-amylase apical plasma membrane;cell surface;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;integral to membrane;intracellular organelle;intrinsic to membrane;melanosome;membrane-bounded organelle;membrane-bounded vesicle;organelle;vesicle amine transmembrane transporter activity;binding;calcium:sodium antiporter activity;catalytic activity;cation transmembrane transporter activity;organic acid transmembrane transporter activity;protein binding;transporter activity amino acid transport;aromatic amino acid transport;calcium ion transport;carbohydrate metabolic process;cation transport;cellular process;di-, tri-valent inorganic cation transport;ion transport;metabolic process;transport 24 24 24 40.7 40.7 40.7 71.122 0 7188700000 3598500000 3590200000 2064 IPI:IPI00554481.1;IPI:IPI00604710.2;IPI:IPI00554722.1;IPI:IPI00027493.1 4F2 cell-surface antigen heavy chain;Lymphocyte activation antigen 4F2 large subunit;4F2 heavy chain antigen SLC3A2;MDU1 P08195-4;P08195;P08195-1;P08195-3;P08195-2 ENST00000338663;ENST00000377889;ENST00000377890;ENST00000377891;ENST00000377892 K06519 4 0.72703 1.4111 0.71587 0.98461 0.90593 0.96394 PGI cell part;cytoplasm;extracellular region part;extracellular space;intracellular part binding;catalytic activity;cytokine activity;glucose-6-phosphate isomerase activity;growth factor activity;intramolecular oxidoreductase activity;isomerase activity;protein binding;receptor binding alcohol metabolic process;angiogenesis;carbohydrate metabolic process;glucose catabolic process;glucose metabolic process;immune system process;monosaccharide metabolic process;organic acid metabolic process;pyruvate metabolic process Glycolysis / Gluconeogenesis;Pentose phosphate pathway;Starch and sucrose metabolism 28 28 28 55.7 55.7 55.7 63.146 0 7414600000 3978900000 3435700000 2065 IPI:IPI00027497.5;IPI:CON_00714446.3 Glucose-6-phosphate isomerase;Phosphoglucose isomerase;Phosphohexose isomerase;Autocrine motility factor;Neuroleukin;Sperm antigen 36 GPI P06744 ENST00000356487 K01810 2 0.59615 0.85521 0.60935 0.75641 0.60104 0.74459 FG-GAP;Integrin_alpha;Integrin_alpha2 adherens junction;cell junction;cell part;cell-substrate adherens junction;cell-substrate junction;cytoplasm;focal adhesion;integrin complex;intracellular part;macromolecular complex;membrane part;plasma membrane part;protein complex;receptor complex binding;calcium ion binding;cation binding;ion binding;metal ion binding;molecular transducer activity;protein binding;receptor activity;signal transducer activity cell adhesion;cell communication;cell-matrix adhesion;negative regulation of myeloid leukocyte differentiation;regulation of immune system process;regulation of myeloid leukocyte differentiation;signal transduction Cell adhesion molecules (CAMs);ECM-receptor interaction;Focal adhesion;Pathways in cancer;Regulation of actin cytoskeleton;Small cell lung cancer 2 2 2 1.8 1.8 1.8 116.04 0.0008981 1643200 881630 761590 2066 IPI:IPI00027505.2;IPI:IPI00555991.2 Integrin alpha-V;Vitronectin receptor subunit alpha;Integrin alpha-V heavy chain;Integrin alpha-V light chain ITGAV;MSK8;VNRA P06756-1;P06756;P06756-2 ENST00000261023;ENST00000374907 K06487 2 0.14904 35.358 0.055088 0.21491 20.625 0.074757 extracellular region binding;cation binding;ion binding;manganese ion binding;metal ion binding;protein binding;transition metal ion binding cellular metabolic process;cellular process;defense response;defense response to bacterium;defense response to fungus;metabolic process;response to bacterium;response to biotic stimulus;response to fungus;response to stress;xenobiotic metabolic process + 6 6 6 47.3 47.3 47.3 11.284 3.8411E-49 246130000 237220000 8910800 2067 IPI:IPI00027547.2 Dermcidin;Preproteolysin;Survival-promoting peptide;DCD-1 DCD;AIDD;DSEP P81605 ENST00000293371 1 0.9144 1.7264 0.91135 1.1846 1.1498 1.1665 Cpn60_TCP1 adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 31 31 27 58.9 58.9 53.3 58.024 0 10633000000 5498100000 5134700000 2070 IPI:IPI00027626.3 T-complex protein 1 subunit zeta;CCT-zeta;CCT-zeta-1;Tcp20;HTR3;Acute morphine dependence-related protein 2 CCT6A;CCT6;CCTZ P40227 ENST00000275603 1 0.61766 1.5135 NaN 0.85926 0.95614 NaN PHD;SAND;Sp100 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding 2 1 1 3.4 1.6 1.6 67.005 4.2375E-13 599950000 332440000 267500000 2071 IPI:IPI00027693.4;IPI:IPI00719187.3;IPI:IPI00884908.1 Nuclear body protein SP140-like protein SP140L Q9H930-1;Q9H930;Q9H930-2;Q9H930-3 ENST00000243810;ENST00000396563 3 1.0139 1.8775 0.91347 1.3836 1.2721 1.2168 Acyl-CoA_dh_1;Acyl-CoA_dh_M;Acyl-CoA_dh_N cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part acyl-CoA dehydrogenase activity;binding;butyryl-CoA dehydrogenase activity;catalytic activity;electron carrier activity;nucleoside binding;nucleotide binding;oxidoreductase activity;purine nucleoside binding catabolic process;cellular process;fatty acid beta-oxidation;fatty acid catabolic process;fatty acid metabolic process;lipid catabolic process;lipid metabolic process;metabolic process;organic acid catabolic process;organic acid metabolic process Butanoate metabolism;Fatty acid metabolism;Valine, leucine and isoleucine degradation 13 13 13 41.5 41.5 41.5 44.297 1.1912E-92 144390000 98559000 45835000 2072 IPI:IPI00027701.3 Short-chain specific acyl-CoA dehydrogenase, mitochondrial;Butyryl-CoA dehydrogenase ACADS P16219 ENST00000242592 K00248 1 0.38847 0.84218 0.42719 0.53772 0.52507 0.61296 DNA_primase_S alpha DNA polymerase:primase complex;cell part;chromosomal part;intracellular organelle part;intracellular part;macromolecular complex;nuclear chromosome part;nuclear part;nucleoplasm;organelle part;protein complex binding;catalytic activity;DNA primase activity;DNA-directed RNA polymerase activity;ion binding;nucleotidyltransferase activity;RNA polymerase activity;transferase activity;transferase activity, transferring phosphorus-containing groups;zinc ion binding biosynthetic process;DNA metabolic process;DNA replication, synthesis of RNA primer;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription DNA replication 10 10 10 26.2 26.2 26.2 49.901 2.2715E-32 59984000 34678000 25306000 2073 IPI:IPI00027704.5 DNA primase small subunit;DNA primase 49 kDa subunit PRIM1 P49642 ENST00000338193 K02684 1 1.228 1.9835 0.40019 1.7827 1.2208 0.54598 DNA_primase_lrg alpha DNA polymerase:primase complex;cell part;chromosomal part;intracellular organelle part;intracellular part;macromolecular complex;nuclear chromosome part;nuclear part;nucleoplasm;organelle part;protein complex binding;catalytic activity;DNA binding;DNA primase activity;DNA-directed RNA polymerase activity;iron ion binding;nucleic acid binding;nucleotidyltransferase activity;transferase activity;transferase activity, transferring phosphorus-containing groups biosynthetic process;DNA metabolic process;DNA replication, synthesis of RNA primer;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription DNA replication 9 9 9 19.6 19.6 19.6 58.805 1.1175E-62 23596000 14411000 9184500 2074 IPI:IPI00027705.2;IPI:IPI00644817.1 DNA primase large subunit;DNA primase 58 kDa subunit PRIM2;PRIM2A P49643-1;P49643 ENST00000389488 K02685 2 0.73627 1.3592 0.76505 0.99867 0.87587 1.0259 bZIP_1;pKID cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;DNA binding;nucleic acid binding;protein binding;protein dimerization activity;sequence-specific DNA binding;transcription cofactor activity;transcription factor activity;transcription factor binding;transcription regulator activity nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein modification process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription;transcription, DNA-dependent Antigen processing and presentation;Huntington's disease;Melanogenesis;Prostate cancer 3 3 3 14.7 14.7 14.7 36.688 3.2183E-07 50102000 26339000 23763000 2075 IPI:IPI00027713.1;IPI:IPI00218334.1;IPI:IPI00748922.3;IPI:IPI00375605.4;IPI:IPI00002501.1;IPI:IPI00847200.1;IPI:IPI00337364.3 Cyclic AMP-responsive element-binding protein 1 CREB1 P16220-1;P16220;P16220-2 ENST00000236996;ENST00000353267 K05870 7 0.42733 0.82888 0.46453 0.56897 0.56688 0.62895 Cajal body;cytosol;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nuclear body;nucleolus;organelle;ribonucleoprotein complex;small nuclear ribonucleoprotein complex;spliceosomal complex binding;protein binding cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing;spliceosomal snRNP biogenesis 16 16 16 16.6 16.6 16.6 119.99 2.6062E-108 357310000 189740000 167570000 2076 IPI:IPI00027717.1 Component of gems 4;Gemin-4;p97 GEMIN4 P57678 ENST00000319004 1 NaN NaN 0.85621 NaN NaN 1.1588 ig;I-set;Pkinase_Tyr cell part;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part catalytic activity;nucleoside binding;nucleotide binding;protein kinase activity;protein tyrosine kinase activity;purine nucleoside binding;receptor activity;signal transducer activity;transmembrane receptor protein tyrosine kinase activity cell activation;cell communication;cell surface receptor linked signal transduction;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;regulation of DNA replication;signal transduction Calcium signaling pathway;Colorectal cancer;Cytokine-cytokine receptor interaction;Focal adhesion;Gap junction;Glioma;MAPK signaling pathway;Melanoma;Pathways in cancer;Prostate cancer;Regulation of actin cytoskeleton 2 1 1 1.3 0.6 0.6 122.67 2.4745E-06 13888000 7291300 6596800 2077 IPI:IPI00027721.1 Alpha-type platelet-derived growth factor receptor;PDGF-R-alpha;CD140 antigen-like family member A;CD140a antigen PDGFRA P16234-1;P16234 ENST00000257290 K04363 1 0.81124 1.2954 0.89937 1.0341 0.93994 1.1041 AA_permease cell part;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part molecular transducer activity;receptor activity;signal transducer activity 4 4 4 8.1 8.1 8.1 67.638 5.8002E-90 241670000 114010000 127660000 2078 IPI:IPI00027728.1;IPI:IPI00930563.1;IPI:IPI00003819.4 High affinity cationic amino acid transporter 1;System Y+ basic amino acid transporter;Solute carrier family 7 member 1;Ecotropic retroviral leukemia receptor homolog;Ecotropic retrovirus receptor homolog SLC7A1;ATRC1;ERR;REC1L P30825 ENST00000380752 3 0.41171 0.91894 0.40796 0.54971 0.66345 0.55242 Pkinase cell part;cytoplasm;intracellular part ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity DNA metabolic process;DNA repair;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process Circadian rhythm - mammal;Hedgehog signaling pathway;Wnt signaling pathway 4 4 2 13.5 13.5 7 47.315 5.0901E-18 16792000 10417000 6374400 2079 IPI:IPI00027729.1 Casein kinase I isoform epsilon CSNK1E P49674 ENST00000359867;ENST00000396832;ENST00000400206;ENST00000402865;ENST00000403904 K08960 1 0.70729 1.3758 0.78335 0.91293 0.94857 1.0617 ubiquitin cell part;cytoplasm;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane part;membrane-bounded organelle;nucleus;organelle 3 3 3 13.4 13.4 13.4 26.261 4.7193E-11 32243000 13304000 18939000 2080 IPI:IPI00027773.3 Transmembrane and ubiquitin-like domain-containing protein 1;Hepatocyte odd protein shuttling protein;Ubiquitin-like protein SB144;Ubiquitin-like protein DULP TMUB1;C7orf21;DULP;HOPS;SB144;UNQ763/PRO1555 Q9BVT8 ENST00000297533;ENST00000392818 1 0.95517 1.8305 0.93894 1.2292 1.1775 1.2386 Ferrochelatase cell part;cytoplasmic part;intracellular organelle part;intracellular part;membrane;mitochondrial inner membrane;mitochondrial matrix;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part 2 iron, 2 sulfur cluster binding;binding;catalytic activity;cation binding;ferrochelatase activity;ferrous iron binding;ion binding;iron ion binding;iron-sulfur cluster binding;lyase activity;metal ion binding;protein binding;transition metal ion binding biosynthetic process;cellular aromatic compound metabolic process;generation of precursor metabolites and energy;heme biosynthetic process;metabolic process;nitrogen compound metabolic process;porphyrin biosynthetic process;porphyrin metabolic process Porphyrin and chlorophyll metabolism 20 20 20 53.7 53.7 53.7 47.862 0 389520000 200380000 189140000 2081 IPI:IPI00027776.6 Ferrochelatase, mitochondrial;Protoheme ferro-lyase;Heme synthetase FECH P22830 ENST00000262093;ENST00000382873 K01772 1 0.85513 1.432 0.79249 1.072 0.9968 1.1399 4 4 4 32.2 32.2 32.2 14.381 1.9023E-13 60886000 30989000 29897000 2082 IPI:IPI00027798.1 Protein FAM103A1 FAM103A1;C15orf18 Q9BTL3 ENST00000304191 1 0.81628 1.7989 1.0548 1.2168 1.1266 1.448 DUF1151 3 3 3 8.5 8.5 8.5 34.759 0.00010122 47457000 24493000 22964000 2083 IPI:IPI00027799.2;IPI:IPI00871831.1 Protein FAM107B FAM107B;C10orf45 Q9H098-2;Q9H098;Q9H098-1 ENST00000181796;ENST00000378458;ENST00000378461;ENST00000378462;ENST00000378465;ENST00000378467;ENST00000378470 2 0.62522 1.1062 0.64006 0.79313 0.7724 0.86027 RNA_pol_Rpb2_1;RNA_pol_Rpb2_2;RNA_pol_Rpb2_3;RNA_pol_Rpb2_4;RNA_pol_Rpb2_5;RNA_pol_Rpb2_6;RNA_pol_Rpb2_7 cell part;DNA-directed RNA polymerase complex;DNA-directed RNA polymerase II, core complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;RNA polymerase complex binding;catalytic activity;DNA binding;DNA-directed RNA polymerase activity;magnesium ion binding;nucleic acid binding;nucleoside binding;protein binding;transferase activity;transferase activity, transferring phosphorus-containing groups;zinc ion binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile Huntington's disease;RNA polymerase 29 29 29 33 33 33 133.9 0 754540000 449110000 305430000 2084 IPI:IPI00027808.1 DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase II subunit B;RNA polymerase II subunit B2;RNA polymerase II subunit 2;DNA-directed RNA polymerase II 140 kDa polypeptide POLR2B P30876 ENST00000314595;ENST00000381227 K03010 1 0.83524 1.5444 NaN 1.1257 0.99975 NaN Homeobox;Pou cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;protein binding;sequence-specific DNA binding;transcription factor activity;transcription regulator activity biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 2 2 2 3.6 3.6 3.6 77.869 3.5278E-11 7188500 3998400 3190000 2085 IPI:IPI00219171.3;IPI:IPI00027828.4;IPI:IPI00555806.1;IPI:IPI00555623.1;IPI:IPI00888702.1;IPI:IPI00012533.3;IPI:IPI00002666.3;IPI:IPI00221055.2;IPI:IPI00748827.2;IPI:IPI00335926.5 POU domain, class 2, transcription factor 1;Octamer-binding transcription factor 1;POU domain, class 2, transcription factor 2;Octamer-binding transcription factor 2;Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2;POU domain, class 2, transcription factor 3;Octamer-binding transcription factor 11;Transcription factor Skn-1;PLA-1 protein POU2F1;OCT1;OTF1;POU2F2;OCT2;OTF2;POU2F3;OTF11;PLA1 P14859-2;P14859;P14859-1;P14859-3;P14859-4;P09086-5;P09086;P09086-1;P09086-3;P09086-2;Q9UKI9;P09086-4 ENST00000271411;ENST00000367862;ENST00000367866;ENST00000292077;ENST00000389341;ENST00000260264 K09364 10 0.71896 1.5009 0.71016 0.9387 1.0032 0.91526 WD40 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part 8 8 8 26.5 26.5 26.5 49.419 1.4086E-245 313690000 168700000 145000000 2086 IPI:IPI00027831.1 Glutamate-rich WD repeat-containing protein 1 GRWD1;GRWD;KIAA1942;WDR28 Q9BQ67 ENST00000253237 1 0.83961 1.6545 0.82851 1.1123 1.0721 1.0939 RRM_1 cell part;heterogeneous nuclear ribonucleoprotein complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;ribonucleoprotein complex binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 21 21 20 58.2 58.2 57 64.132 0 5657300000 2890900000 2766400000 2087 IPI:IPI00027834.3 Heterogeneous nuclear ribonucleoprotein L HNRNPL;HNRPL;P/OKcl.14 P14866 ENST00000221419 1 0.60298 NaN NaN 0.72936 NaN NaN RRM_1;zf-CCHC cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;cation binding;ion binding;metal ion binding;nucleic acid binding;nucleotide binding;RNA binding;transition metal ion binding;zinc ion binding cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 13 1 1 35.9 4.5 4.5 40.149 4.5289E-94 1615800 986820 629000 2088 IPI:IPI00027838.1 RNA-binding protein 4B;RNA-binding motif protein 4B;RNA-binding protein 30;RNA-binding motif protein 30 RBM4B;RBM30 Q9BQ04 ENST00000310046 1 0.48826 0.8753 0.57007 0.59998 0.62606 0.70639 3 3 3 15.7 15.7 15.7 25.456 1.852E-31 43172000 23987000 19185000 2090 IPI:IPI00027898.3;IPI:IPI00217294.1 Uncharacterized protein C21orf70 C21orf70;PRED56 Q9NSI2-1;Q9NSI2;Q9NSI2-2 ENST00000291634 2 NaN 1.8982 NaN NaN 1.2111 NaN Proteasome cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;proteasome core complex;protein complex catalytic activity;endopeptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides;threonine-type endopeptidase activity;threonine-type peptidase activity catabolic process;cellular process;humoral immune response;immune response;immune system process;macromolecule catabolic process;metabolic process;proteasomal protein catabolic process;proteolysis;ubiquitin-dependent protein catabolic process Proteasome 2 2 2 8.4 8.4 8.4 28.936 0.003712 5551200 3450400 2100700 2091 IPI:IPI00027933.3 Proteasome subunit beta type-10;Proteasome subunit beta-2i;Proteasome MECl-1;Macropain subunit MECl-1;Multicatalytic endopeptidase complex subunit MECl-1 PSMB10;MECL1 P40306 ENST00000358514 K02733 1 0.7984 1.4821 0.75404 1.0355 0.95903 0.977 KH_1 cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;ribonucleoprotein complex binding;DNA binding;nucleic acid binding;RNA binding cellular biopolymer metabolic process;cellular process;macromolecule metabolic process;metabolic process;mRNA metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process 4 1 1 15.4 3.2 3.2 39.465 2.8523E-124 83975000 44923000 39052000 2093 IPI:IPI00027970.5;IPI:IPI00410587.2;IPI:IPI00167750.5;IPI:IPI00101278.7;IPI:IPI00410586.1 Poly(rC)-binding protein 3;Alpha-CP3 PCBP3 P57721-1;P57721;P57721-4;P57721-5;P57721-2;P57721-3 ENST00000400304;ENST00000400314 5 0.88076 1.5374 0.94228 1.1738 1.0247 1.1409 zf-C2H2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;protein binding;RNA polymerase II transcription factor activity;transcription cofactor activity;transcription corepressor activity;transcription factor activity;transcription factor binding;zinc ion binding negative regulation of transcription from RNA polymerase II promoter;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 13 13 13 18.8 18.8 18.8 82.785 4.2922E-138 287550000 142640000 144910000 2094 IPI:IPI00027988.1 Transcriptional repressor CTCF;CCCTC-binding factor;CTCFL paralog;11-zinc finger protein CTCF P49711 ENST00000264010 1 0.6799 1.2844 0.73962 0.88119 0.85463 0.92565 DUF1900;WD40 cell fraction;cytoplasmic vesicle;cytosol;Golgi membrane;insoluble fraction;integral to membrane of membrane fraction;intracellular organelle;membrane;membrane fraction;organelle;organelle membrane;organelle part;soluble fraction;vesicle 14 14 14 23.6 23.6 23.6 100.6 0 196530000 107820000 88705000 2095 IPI:IPI00027996.2;IPI:IPI00940326.1 Coronin-7;70 kDa WD repeat tumor rejection antigen homolog CORO7 P57737-1;P57737;P57737-2 ENST00000251166 2 0.85369 1.721 0.79566 1.1514 1.1197 1.0849 Proteasome cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;proteasome core complex;protein complex binding;catalytic activity;endopeptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides;protein binding;threonine-type endopeptidase activity;threonine-type peptidase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Proteasome 11 11 11 51.7 51.7 51.7 22.949 0 1552200000 843050000 709110000 2096 IPI:IPI00028004.2 Proteasome subunit beta type-3;Proteasome theta chain;Proteasome chain 13;Proteasome component C10-II PSMB3 P49720 ENST00000225426 K02735 1 0.63179 1.2172 0.63391 0.79672 0.78089 0.80643 Nup84_Nup100 condensed chromosome kinetochore;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;kinetochore;macromolecular complex;membrane part;non-membrane-bounded organelle;nuclear pore;organelle;organelle part;protein complex binding;nucleocytoplasmic transporter activity;protein binding;transporter activity cellular process;establishment of protein localization;intracellular protein transport;mRNA export from nucleus;nucleobase, nucleoside, nucleotide and nucleic acid transport;nucleocytoplasmic transport;protein transport;RNA export from nucleus;transport 15 15 15 19.1 19.1 19.1 106.37 5.8433E-213 266350000 146820000 119530000 2097 IPI:IPI00028005.1 Nuclear pore complex protein Nup107;Nucleoporin Nup107;107 kDa nucleoporin NUP107 P57740 ENST00000229179 1 0.90295 1.6291 0.85843 1.152 1.1343 1.1366 Proteasome cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;proteasome core complex;protein complex catalytic activity;endopeptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides;threonine-type endopeptidase activity;threonine-type peptidase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Proteasome 10 10 10 39.3 39.3 39.3 22.836 6.7278E-173 2995000000 1546200000 1448800000 2098 IPI:IPI00028006.1 Proteasome subunit beta type-2;Proteasome component C7-I;Macropain subunit C7-I;Multicatalytic endopeptidase complex subunit C7-I PSMB2 P49721 ENST00000373237;ENST00000373240 K02734 1 1.2402 1.8572 NaN 1.5555 1.2534 NaN cell part;extracellular region;integral to membrane;intrinsic to membrane;membrane;membrane part;plasma membrane binding;molecular transducer activity;protein binding;receptor activity;signal transducer activity immune response;immune system process;response to stimulus 2 2 2 7.7 7.7 7.7 31.412 1.1634E-09 7624500 3684800 3939600 2099 IPI:IPI00433028.2;IPI:IPI00028015.2;IPI:IPI00657756.2;IPI:IPI00788236.1;IPI:IPI00032545.2;IPI:IPI00010137.2 Leukocyte-associated immunoglobulin-like receptor 1;Leukocyte-associated immunoglobulin-like receptor 2 LAIR1;CD305;LAIR2;CD306 Q6GTX8-1;Q6GTX8;Q6GTX8-2;Q6GTX8-3;Q6GTX8-4;Q6ISS4-1;Q6ISS4;Q6ISS4-2 ENST00000348231;ENST00000391742;ENST00000301202;ENST00000351841 K06725 6 0.76741 1.4792 0.87899 0.94604 0.97656 1.0794 Gasdermin 4 4 4 14.3 14.3 14.3 52.8 1.4965E-09 69937000 35388000 34549000 2100 IPI:IPI00028027.3 Gasdermin-D;Gasdermin domain-containing protein 1 GSDMD;DFNA5L;GSDMDC1;FKSG10 P57764 ENST00000262580 1 0.6703 1.4186 0.66136 0.88968 0.96532 0.87147 GTP_EFTU;GTP_EFTU_D2 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;nucleic acid binding;nucleotide binding;pyrophosphatase activity;translation elongation factor activity;translation factor activity, nucleic acid binding 13 13 13 25.7 25.7 25.7 65.304 5.4518E-40 115490000 61649000 53841000 2101 IPI:IPI00028050.3 Selenocysteine-specific elongation factor;Elongation factor sec;Eukaryotic elongation factor, selenocysteine-tRNA-specific EEFSEC;SELB P57772 ENST00000254730 1 NaN NaN 0.66231 NaN NaN 0.85203 Clathrin binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding cellular process;establishment of localization;establishment of localization in cell;establishment of protein localization;intracellular protein transport;intracellular transport;protein transport;transport;vesicle-mediated transport 3 3 3 3.4 3.4 3.4 98.565 7.3868E-26 11483000 6091800 5391100 2102 IPI:IPI00028051.2;IPI:IPI00215972.2 Vacuolar protein sorting-associated protein 41 homolog;S53 VPS41 P49754-1;P49754;P49754-2 ENST00000310301 2 0.8634 1.8634 0.83816 1.1729 1.153 1.1397 EMP24_GP25L cell fraction;cis-Golgi network;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle membrane;ER-Golgi intermediate compartment;Golgi membrane;insoluble fraction;integral to membrane;membrane;membrane fraction;microsome;vesicle membrane binding;protein binding cellular process;establishment of protein localization;exocytosis;protein transport;regulated secretory pathway;secretion;secretion by cell;transport;vesicle targeting;vesicle targeting, to, from or within Golgi;vesicle-mediated transport 7 7 7 31.1 31.1 31.1 24.976 4.5107E-139 1409700000 743890000 665830000 2103 IPI:IPI00028055.4 Transmembrane emp24 domain-containing protein 10;21 kDa transmembrane-trafficking protein;Transmembrane protein Tmp21;Tmp-21-I;p24delta;S31III125 TMED10;TMP21 P49755 ENST00000303575 1 0.23173 0.64449 0.2756 0.28992 0.41192 0.34791 Trypsin cell part;cell surface binding;catalytic activity;endopeptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides;protein binding;serine hydrolase activity;serine-type endopeptidase activity;serine-type peptidase activity catabolic process;defense response;immune response;immune system process;macromolecule catabolic process;metabolic process;protein catabolic process;protein metabolic process;proteolysis;response to bacterium;response to biotic stimulus;response to stress Neuroactive ligand-receptor interaction;Renin-angiotensin system;Systemic lupus erythematosus 3 3 3 18.8 18.8 18.8 28.837 2.6077E-05 5500600 3091300 2409300 2104 IPI:IPI00028064.1 Cathepsin G CTSG P08311 ENST00000216336 K01319 1 NaN 1.6057 0.82343 NaN 0.86479 1.1085 SH2;SH3_1 cell part;cytoplasmic part;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle binding;cytoskeletal adaptor activity;cytoskeletal protein binding;molecular adaptor activity;protein binding;protein complex scaffold;receptor binding;receptor signaling complex scaffold activity;structural molecule activity cell activation;immune system process;positive regulation of immune system process;positive regulation of leukocyte activation;protein complex assembly;regulation of immune system process;regulation of leukocyte activation;regulation of translation ErbB signaling pathway;T cell receptor signaling pathway 5 5 4 14.3 14.3 12.2 42.864 4.8575E-18 62096000 33568000 28528000 2105 IPI:IPI00028065.1 Cytoplasmic protein NCK1;NCK adaptor protein 1;SH2/SH3 adaptor protein NCK-alpha NCK1;NCK P16333 ENST00000288986 K07365 1 0.52821 1.3034 0.64412 0.70248 0.88414 0.81055 Mito_carr cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part binding;nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity;nucleotide transmembrane transporter activity;substrate-specific transmembrane transporter activity;transmembrane transporter activity;transporter activity deoxynucleotide transport;establishment of localization;nucleobase, nucleoside, nucleotide and nucleic acid transport;nucleotide transport;transport 5 5 5 16.2 16.2 16.2 35.511 7.0616E-20 31103000 18560000 12543000 2106 IPI:IPI00028068.3 Mitochondrial thiamine pyrophosphate carrier;Solute carrier family 25 member 19;Mitochondrial uncoupling protein 1 SLC25A19;DNC;MUP1 Q9HC21 ENST00000320362;ENST00000402418 1 0.66613 1.6586 0.72226 0.85098 1.0554 0.94684 IF-2B cell part;cytoplasmic part;eukaryotic translation initiation factor 2B complex;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;protein complex ATP binding;binding;GTP binding;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;translation factor activity, nucleic acid binding;translation initiation factor activity axon ensheathment;ensheathment of neurons;ovarian follicle development;regulation of translation;regulation of translational initiation;response to heat;response to stress;response to temperature stimulus;translational initiation 9 9 9 24.5 24.5 24.5 38.989 9.6022E-117 306280000 166460000 139820000 2108 IPI:IPI00028083.1 Translation initiation factor eIF-2B subunit beta;eIF-2B GDP-GTP exchange factor subunit beta;S20I15;S20III15 EIF2B2;EIF2BB P49770 ENST00000266126 K03754 1 1.0052 2.0004 0.99141 1.3389 1.3155 1.32 Actin Arp2/3 protein complex;cell part;cytoplasm;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;organelle part;protein complex actin binding;adenyl nucleotide binding;ATP binding;binding;cytoskeletal protein binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cell motion;cellular process;regulation of actin filament length;regulation of actin filament polymerization;regulation of actin polymerization or depolymerization;regulation of cellular metabolic process;regulation of metabolic process 27 27 27 61.5 61.5 61.5 47.371 0 3134900000 1576800000 1558100000 2109 IPI:IPI00028091.3;IPI:IPI00007068.1;IPI:IPI00892652.1;IPI:IPI00946655.1 Actin-related protein 3;Actin-like protein 3 ACTR3;ARP3 P61158 ENST00000263238 4 0.75627 1.4489 0.87636 0.91002 1.0341 1.0673 Dpy-30 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;identical protein binding;protein binding 2 2 2 25.3 25.3 25.3 11.25 5.8073E-10 105410000 56033000 49375000 2110 IPI:IPI00028109.1 Protein dpy-30 homolog;Dpy-30-like protein DPY30 Q9C005 ENST00000295066;ENST00000342166 1 0.68264 1.5485 0.71757 0.98248 0.93631 1.0458 PWWP cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding biosynthetic process;DNA metabolic process;DNA recombination;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 15 15 14 30.4 30.4 28.9 60.103 2.8348E-224 860600000 455600000 405000000 2111 IPI:IPI00028122.1;IPI:IPI00333317.4 PC4 and SFRS1-interacting protein;Lens epithelium-derived growth factor;Transcriptional coactivator p75/p52;Dense fine speckles 70 kDa protein;CLL-associated antigen KW-7 PSIP1;DFS70;LEDGF;PSIP2 O75475-1;O75475;O75475-2 ENST00000380716;ENST00000380733;ENST00000380738 2 0.40119 1.0318 0.55846 0.54381 0.65803 0.81562 Ets;SAM_PNT cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;protein binding;sequence-specific DNA binding;transcription factor activity;transcription factor binding;transcription regulator activity immune system process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of immune system process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription Dorso-ventral axis formation;MAPK signaling pathway - fly 4 4 4 14.5 14.5 14.5 50.407 1.1633E-89 63865000 34209000 29656000 2112 IPI:IPI00028127.1;IPI:IPI00218351.1;IPI:IPI00009756.1 Protein C-ets-1;p54 ETS1;EWSR2 P14921-1;P14921;P14921-2 ENST00000319397;ENST00000345075;ENST00000392668 K02678 3 0.7444 1.3773 0.74604 0.91487 0.88579 1.0055 Porphobil_deam;Porphobil_deamC cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle catalytic activity;hydroxymethylbilane synthase activity;transferase activity;transferase activity, transferring alkyl or aryl (other than methyl) groups biosynthetic process;cellular process;heme biosynthetic process;heterocycle biosynthetic process;metabolic process;nitrogen compound metabolic process;porphyrin biosynthetic process;porphyrin metabolic process;tetrapyrrole metabolic process Porphyrin and chlorophyll metabolism 10 10 10 41.3 41.3 41.3 39.33 7.0002E-166 341100000 189810000 151280000 2113 IPI:IPI00028160.1;IPI:IPI00219877.1 Porphobilinogen deaminase;Pre-uroporphyrinogen synthase;Hydroxymethylbilane synthase HMBS;PBGD;UPS P08397-1;P08397;P08397-2 ENST00000278715;ENST00000392841 K01749 2 0.7519 NaN NaN 0.94603 NaN NaN DHH;DHHA2 adherens junction;cell junction;cell-substrate adherens junction;cell-substrate junction;cytoplasm;focal adhesion;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;inorganic diphosphatase activity;protein binding;pyrophosphatase activity Purine metabolism 2 2 2 5.3 5.3 5.3 50.199 2.2403E-18 2998000 1731300 1266700 2114 IPI:IPI00166931.5;IPI:IPI00028177.5;IPI:IPI00155261.5;IPI:IPI00895854.2;IPI:IPI00895809.2;IPI:IPI00929544.1;IPI:IPI00645747.1 Protein prune homolog;Drosophila-related expressed sequence 17;HTcD37 PRUNE Q86TP1-1;Q86TP1;Q86TP1-5;Q86TP1-2;Q86TP1-3;Q86TP1-4;Q86TP1-7;Q86TP1-6 ENST00000271619;ENST00000271620;ENST00000302413 K01514 7 0.55777 NaN 0.56678 0.74669 NaN 0.76221 SIN1 cell part;cytoplasmic part;cytoplasmic vesicle;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;nucleus;organelle;plasma membrane;vesicle binding;enzyme binding;GTPase binding;protein binding;Ras GTPase binding;small GTPase binding 2 2 2 4.8 4.8 4.8 59.122 1.3988E-78 4792200 2861500 1930800 2115 IPI:IPI00028195.1;IPI:IPI00216277.1;IPI:IPI00550208.1;IPI:IPI00890691.1;IPI:IPI00549186.1;IPI:IPI00549688.1 Target of rapamycin complex 2 subunit MAPKAP1;Mitogen-activated protein kinase 2-associated protein 1;Stress-activated map kinase-interacting protein 1 MAPKAP1;MIP1;SIN1 Q9BPZ7-1;Q9BPZ7;Q9BPZ7-2;Q9BPZ7-3;Q9BPZ7-6;Q9BPZ7-5;Q9BPZ7-4 ENST00000265960;ENST00000350766;ENST00000373498;ENST00000373503;ENST00000373505;ENST00000373511;ENST00000394057;ENST00000394063 6 0.75921 1.4943 0.70388 1.0132 0.94804 0.94551 PH;Vps51 cell part;cell projection;cytoplasm;growth cone;intracellular part;neuron projection;site of polarized growth binding;protein binding cellular process;establishment of localization;establishment of localization in cell;establishment of protein localization;exocytosis;protein transport;secretion;secretion by cell;transport;vesicle-mediated transport 9 9 9 15.2 15.2 15.2 81.798 1.0484E-148 78380000 42919000 35461000 2116 IPI:IPI00028264.3 Exocyst complex component 8;Exocyst complex 84 kDa subunit EXOC8 Q8IYI6 ENST00000360394 1 0.59561 1.2416 0.64393 0.79601 0.80715 0.8461 Cyclin_C;Cyclin_N cytoskeleton;cytosol;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;microtubule cytoskeleton;non-membrane-bounded organelle;nucleus;organelle binding;protein binding cell cycle phase;cell cycle process;cell division;cellular component organization;cellular process;mitosis;nuclear division;organelle fission;organelle organization Cell cycle;p53 signaling pathway;Progesterone-mediated oocyte maturation 5 5 5 15.8 15.8 15.8 45.281 2.0289E-29 31015000 17771000 13244000 2117 IPI:IPI00028266.1 G2/mitotic-specific cyclin-B2 CCNB2 O95067 ENST00000288207 K05868 1 0.92198 1.755 0.9548 1.2514 1.137 1.2469 HEAT centrosome;cytoplasmic part;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;microtubule organizing center;non-membrane-bounded organelle;organelle;organelle part binding;protein binding cellular process;cytoskeleton organization;microtubule cytoskeleton organization;microtubule-based process;mitosis;nuclear division;nucleobase, nucleoside, nucleotide and nucleic acid transport;organelle organization;transport 68 68 68 35.8 35.8 35.8 226.25 0 2603600000 1172700000 1430900000 2118 IPI:IPI00921422.1;IPI:IPI00028275.2;IPI:IPI00472887.3 Cytoskeleton-associated protein 5;Colonic and hepatic tumor over-expressed protein;Ch-TOG protein CKAP5;KIAA0097 Q14008-3;Q14008;Q14008-1;Q14008-2 ENST00000354558 3 NaN 1.5381 1.2433 NaN 0.92203 1.6746 zf-CCCH binding;cation binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transition metal ion binding;zinc ion binding 4 4 4 6.3 6.3 6.3 96.495 2.3123E-26 13301000 6126400 7174300 2119 IPI:IPI00028276.5 RING finger protein unkempt homolog;Zinc finger CCCH domain-containing protein 5 UNK;KIAA1753;ZC3H5;ZC3HDC5 Q9C0B0 ENST00000293218 1 0.87167 1.5855 0.90992 1.163 1.0223 1.2211 anatomical structure morphogenesis;appendage morphogenesis;determination of bilateral symmetry;determination of left/right symmetry;determination of symmetry;developmental process;embryonic limb morphogenesis;pattern specification process 8 8 8 18.8 18.8 18.8 58.281 7.8886E-125 72351000 37678000 34673000 2120 IPI:IPI00028277.8;IPI:IPI00845477.1;IPI:IPI00845501.1;IPI:IPI00845224.1 Protein fto;Fat mass and obesity-associated protein FTO;KIAA1752 Q9C0B1-1;Q9C0B1 ENST00000268349;ENST00000394644;ENST00000394645;ENST00000394647 4 0.77637 1.4474 0.92266 0.98431 1.0271 1.1396 NAP cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;chromatin organization;nucleosome assembly;organelle organization 5 5 5 18.5 18.5 18.5 45.143 1.9741E-21 170370000 90893000 79480000 2121 IPI:IPI00028279.5 Testis-specific Y-encoded-like protein 5 TSPYL5;KIAA1750 Q86VY4 ENST00000322128 K11288 1 0.7614 1.6504 0.69502 1.0146 1.0943 0.89829 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding establishment of localization;establishment of protein localization;protein transport;transport 8 8 8 9 9 9 130.14 2.8714E-52 60611000 34735000 25876000 2122 IPI:IPI00028357.2 Exportin-4 XPO4;KIAA1721 Q9C0E2 ENST00000255305;ENST00000400602 1 0.80016 1.427 0.81884 1.0462 0.97961 1.0861 MORN;SET cell part;chromosome;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle binding;catalytic activity;lysine N-methyltransferase activity;methyltransferase activity;N-methyltransferase activity;protein binding;protein methyltransferase activity;S-adenosylmethionine-dependent methyltransferase activity biosynthetic process;chromatin organization;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;regulation of transcription, DNA-dependent;transcription Lysine degradation 2 2 2 7.4 7.4 7.4 40.72 5.3546E-91 11127000 5971800 5155300 2124 IPI:IPI00028366.2 Histone-lysine N-methyltransferase SETD7;Histone H3-K4 methyltransferase SETD7;H3-K4-HMTase SETD7;SET domain-containing protein 7;SET7/9;Lysine N-methyltransferase 7 SETD7;KIAA1717;KMT7;SET7;SET9 Q8WTS6 ENST00000274031 K11431 1 0.79292 1.9282 0.93205 1.0699 1.2329 1.2033 DUF2296 cell part;integral to membrane;intrinsic to membrane;membrane part binding;protein binding anatomical structure development;appendage development;developmental process;limb development 6 6 6 18.5 18.5 18.5 47.739 3.728E-28 30569000 16463000 14106000 2125 IPI:IPI00028369.6;IPI:IPI00785171.1;IPI:IPI00784901.1 Protein lunapark LNP;KIAA1715 Q9C0E8-1;Q9C0E8;Q9C0E8-2;Q9C0E8-3 ENST00000272748;ENST00000392540 3 0.63496 1.3143 0.71991 0.81775 0.88131 0.90098 zf-Tim10_DDP intracellular part;macromolecular complex;membrane;mitochondrial inner membrane;mitochondrial intermembrane space protein transporter complex;mitochondrial membrane;organelle inner membrane;organelle membrane;organelle part;protein complex binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding intracellular protein transport;mitochondrial membrane organization;mitochondrial transport;mitochondrion organization;organelle organization;protein targeting;protein targeting to membrane;protein targeting to mitochondrion;system process;transport 5 5 5 55.7 55.7 55.7 10.998 2.8386E-38 113220000 60104000 53118000 2126 IPI:IPI00028376.1 Mitochondrial import inner membrane translocase subunit Tim8 A;Deafness dystonia protein 1;X-linked deafness dystonia protein TIMM8A;DDP;DDP1;TIM8A O60220 ENST00000372902 1 0.88261 1.714 0.88742 1.1011 1.2061 1.137 DDRGK extracellular region binding;protein binding 5 5 5 24.2 24.2 24.2 35.61 1.3906E-136 125530000 62622000 62911000 2127 IPI:IPI00028387.3;IPI:IPI00375407.1 DDRGK domain-containing protein 1 DDRGK1;C20orf116 Q96HY6-1;Q96HY6;Q96HY6-2 ENST00000354488;ENST00000380213 2 0.8375 1.5523 0.88138 1.0402 1.1104 1.0424 Auto_anti-p27 cell cycle phase;cell cycle process;cell division;cellular component organization;cellular process;mitosis;nuclear division;organelle fission;organelle organization 4 4 4 30.7 30.7 30.7 21.474 2.0992E-64 120610000 57413000 63201000 2128 IPI:IPI00028412.1 Sjoegren syndrome/scleroderma autoantigen 1;Autoantigen p27 SSSCA1 O60232 ENST00000309328 1 0.67881 1.4881 0.80445 0.90127 0.9439 1.0676 Cofilin_ADF cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;nucleus;organelle actin binding;binding;cytoskeletal protein binding;enzyme activator activity;enzyme inhibitor activity;growth factor activity;kinase inhibitor activity;kinase regulator activity;protein binding;protein kinase inhibitor activity;receptor binding cellular biopolymer metabolic process;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process 10 10 9 52.1 52.1 52.1 16.801 6.539E-84 1112000000 580050000 531940000 2129 IPI:IPI00028414.3 Glia maturation factor gamma GMFG O60234 ENST00000253054 1 0.81542 1.0354 NaN 1.0266 0.72779 NaN Motile_Sperm cell part;integral to membrane;intrinsic to membrane;membrane part structural molecule activity 2 2 2 11.5 11.5 11.5 25.518 8.62E-11 749240 366120 383120 2130 IPI:IPI00028431.1;IPI:IPI00604514.1;IPI:IPI00382548.1 Motile sperm domain-containing protein 3 MOSPD3 O75425-1;O75425;O75425-2;O75425-3 ENST00000223054;ENST00000379527;ENST00000393950;ENST00000393953 3 0.81501 1.6479 0.88761 1.0946 1.0794 1.21 Ras cell part;cell projection;cilium;membrane;nonmotile primary cilium;plasma membrane binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;protein binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cell communication;cellular process;intracellular signaling cascade;membrane fusion;organelle organization;signal transduction;small GTPase mediated signal transduction;transport;vesicle docking during exocytosis;vesicle fusion 11 7 4 51.2 36.7 22.2 23.668 1.5318E-219 393860000 152840000 241030000 2131 IPI:IPI00028481.1 Ras-related protein Rab-8A;Oncogene c-mel RAB8A;MEL;RAB8 P61006 ENST00000300935 K07901 1 0.5123 1.3354 NaN 0.65142 0.95821 NaN Acyltransferase cell part;cytoplasmic part;cytosol;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane part;membrane-bounded organelle;mitochondrion;organelle 1-acylglycerol-3-phosphate O-acyltransferase activity;acetyltransferase activity;acylglycerol O-acyltransferase activity;acyltransferase activity;catalytic activity;N-acetyltransferase activity;N-acyltransferase activity;O-acyltransferase activity biosynthetic process;cellular metabolic process;cellular process;lipid biosynthetic process;lipid metabolic process;metabolic process;organophosphate metabolic process;phospholipid biosynthetic process;phospholipid metabolic process 2 2 2 5.8 5.8 5.8 42.072 2.9123E-23 11826000 7189100 4636700 2132 IPI:IPI00028491.4 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon;1-acylglycerol-3-phosphate O-acyltransferase 5;Lysophosphatidic acid acyltransferase epsilon AGPAT5 Q9NUQ2 ENST00000285518 1 0.37858 0.76448 NaN 0.5165 0.51864 NaN Rap_GAP;Tuberin cell fraction;Golgi apparatus;insoluble fraction;intracellular membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane;membrane fraction;membrane-bounded organelle;nucleus;organelle;protein complex;TSC1-TSC2 complex binding;enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;identical protein binding;protein binding;protein dimerization activity;protein homodimerization activity cell cycle;chemotaxis;endocytosis;intracellular protein transport;morphogenesis of an epithelium;negative regulation of protein kinase activity;neural tube closure;nucleocytoplasmic transport;protein import into nucleus;protein targeting;transport 6 6 6 3.4 3.4 3.4 200.61 7.859E-38 8627100 5298000 3329100 2133 IPI:IPI00028493.4;IPI:IPI00218883.2;IPI:IPI00218881.2;IPI:IPI00952929.2;IPI:IPI00879496.1;IPI:IPI00954095.1 Tuberin;Tuberous sclerosis 2 protein TSC2;TSC4 P49815-1;P49815;P49815-4;P49815-2;P49815-3;P49815-5;P49815-6 ENST00000219476;ENST00000350773;ENST00000353929 6 0.62203 0.98529 0.5648 0.80342 0.65711 0.72988 Ras cell part;membrane;plasma membrane binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleotide binding;pyrophosphatase activity cell communication;cellular process;establishment of protein localization;intracellular signaling cascade;protein transport;regulation of biological process;signal transduction;small GTPase mediated signal transduction;transport 5 5 4 26.2 26.2 21.5 26.592 7.211E-34 85040000 48336000 36704000 2134 IPI:IPI00028517.1 Ras-related protein Rab-33A;Small GTP-binding protein S10 RAB33A;RABS10 Q14088 ENST00000257017 K07919 1 0.79729 1.3881 0.81715 1.0157 0.90349 1.0192 Complex1_51K;NADH_4Fe-4S;SLBB cytoplasmic part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;mitochondrial membrane part;mitochondrial part;mitochondrial respiratory chain complex I;NADH dehydrogenase complex;organelle part;protein complex binding;catalytic activity;FMN binding;iron ion binding;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;sugar binding cellular metabolic process;cellular process;electron transport chain;generation of precursor metabolites and energy;metabolic process;mitochondrial electron transport, NADH to ubiquinone;respiratory electron transport chain;transport Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 15 15 15 35.6 35.6 35.6 50.817 7.7212E-103 281610000 150010000 131600000 2135 IPI:IPI00028520.2;IPI:IPI00221298.1 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial;NADH-ubiquinone oxidoreductase 51 kDa subunit;Complex I-51kD;NADH dehydrogenase flavoprotein 1 NDUFV1;UQOR1 P49821-1;P49821;P49821-2 ENST00000322776 K03942 2 0.81892 1.8241 0.92409 1.1061 1.1424 1.2366 GBP;GBP_C cell part;membrane;plasma membrane binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleotide binding;pyrophosphatase activity immune response;immune system process;response to stimulus 6 6 5 8.4 8.4 8.4 67.902 1.1734E-07 56579000 29591000 26988000 2136 IPI:IPI00028564.1 Interferon-induced guanylate-binding protein 1;Guanine nucleotide-binding protein 1;GTP-binding protein 1 GBP1 P32455 ENST00000370473 1 0.50961 1.0977 0.57951 0.7314 0.64329 0.6963 Pkinase Axin-APC-beta-catenin-GSK3B complex;beta-catenin destruction complex;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;protein complex ATP binding;beta-catenin binding;binding;catalytic activity;glycogen synthase kinase 3 activity;nucleoside binding;nucleotide binding;p53 binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding carbohydrate metabolic process;cellular glucan metabolic process;energy reserve metabolic process;generation of precursor metabolites and energy;glycogen metabolic process;polysaccharide metabolic process;protein modification process Alzheimer's disease;Axon guidance;B cell receptor signaling pathway;Basal cell carcinoma;Cell cycle;Chemokine signaling pathway;Circadian rhythm - fly;Colorectal cancer;Endometrial cancer;ErbB signaling pathway;Focal adhesion;Hedgehog signaling pathway;Insulin signaling pathway;Melanogenesis;Pathways in cancer;Prostate cancer;T cell receptor signaling pathway;Wnt signaling pathway 8 8 6 22.2 22.2 18.7 48.033 3.5141E-39 77815000 41220000 36595000 2137 IPI:IPI00216190.1;IPI:IPI00028570.2 Glycogen synthase kinase-3 beta GSK3B P49841-2;P49841;P49841-1 ENST00000264235;ENST00000316626 K03083 2 0.71018 1.5007 0.75357 0.95876 1.0754 0.97072 DUF1546;TAF cytoplasm;histone acetyltransferase complex;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex;transcription factor complex;transcription factor TFIID complex;transcription factor TFTC complex binding;DNA binding;general RNA polymerase II transcription factor activity;nucleic acid binding;protein binding;RNA polymerase II transcription factor activity;transcription initiation factor activity;transcription regulator activity nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;RNA elongation;transcription initiation;transcription initiation from RNA polymerase II promoter Basal transcription factors 4 4 4 8 8 8 72.668 6.2315E-21 55286000 29805000 25481000 2138 IPI:IPI00028579.3;IPI:IPI00376952.1 Transcription initiation factor TFIID subunit 6;Transcription initiation factor TFIID 70 kDa subunit;TAFII-80;RNA polymerase II TBP-associated factor subunit E TAF6;TAF2E;TAFII70 P49848-1;P49848;P49848-2 ENST00000344095 K03131 2 0.86121 1.6845 0.90072 1.1235 1.1306 1.1572 Ribophorin_II cell part;cytoplasmic part;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;macromolecular complex;membrane part;oligosaccharyltransferase complex;organelle part;protein complex binding;catalytic activity;dolichyl-diphosphooligosaccharide-protein glycotransferase activity;oligosaccharyl transferase activity;protein binding;transferase activity;transferase activity, transferring glycosyl groups carbohydrate metabolic process;cellular process;metabolic process;peptidyl-amino acid modification;peptidyl-asparagine modification;protein amino acid glycosylation;protein amino acid N-linked glycosylation;protein modification process 21 21 21 45.2 45.2 45.2 69.283 0 2004400000 1036700000 967730000 2140 IPI:IPI00028635.5 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2;Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit;Ribophorin-2;Ribophorin II;RIBIIR RPN2 P04844 ENST00000237530;ENST00000373632 1 NaN 1.4458 0.83054 NaN 0.89081 1.0704 NDUF_B8 endoplasmic reticulum;integral to membrane;intracellular organelle;intrinsic to membrane;macromolecular complex;membrane-bounded organelle;mitochondrial respiratory chain complex I;NADH dehydrogenase complex;organelle catalytic activity;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor cellular metabolic process;cellular process;electron transport chain;generation of precursor metabolites and energy;metabolic process;mitochondrial electron transport, NADH to ubiquinone;respiratory electron transport chain;transport Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 2 2 2 14.5 14.5 14.5 21.766 0.0038225 69226000 36380000 32846000 2141 IPI:IPI00028883.1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial;NADH-ubiquinone oxidoreductase ASHI subunit;Complex I-ASHI NDUFB8 O95169 ENST00000299166 K03964 1 0.73996 1.5454 0.68832 1.0057 0.97054 0.97875 CBFNT;RRM_1 chromosome;heterogeneous nuclear ribonucleoprotein complex;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;organelle;organelle part;ribonucleoprotein complex binding;DNA binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding;sequence-specific DNA binding;telomeric DNA binding;transcription activator activity;transcription regulator activity nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile;transcription 22 22 21 39.2 39.2 39.2 38.434 0 9787000000 5190300000 4596600000 2142 IPI:IPI00028888.1;IPI:IPI00220684.1;IPI:IPI00220683.1;IPI:IPI00220685.1 Heterogeneous nuclear ribonucleoprotein D0;AU-rich element RNA-binding protein 1 HNRNPD;AUF1;HNRPD Q14103-1;Q14103;Q14103-3;Q14103-2;Q14103-4 ENST00000313899;ENST00000352301;ENST00000353341 4 NaN NaN 0.92971 NaN NaN 1.4765 zf-C2H2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;RNA polymerase II transcription factor activity;specific RNA polymerase II transcription factor activity;transcription regulator activity;zinc ion binding nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;response to stress;transcription 2 2 2 6.9 6.9 6.9 56.931 3.8017E-26 1192600 594870 597690 2143 IPI:IPI00028912.2 Vascular endothelial zinc finger 1;Zinc finger protein 161;Putative transcription factor DB1 VEZF1;DB1;ZNF161 Q14119 ENST00000258963 1 0.79088 1.7415 1.3221 0.98742 1.2173 1.6167 Cadherin anchoring junction;cell junction;cell part;cell-cell junction;desmosome;integral to membrane;intrinsic to membrane;membrane part;plasma membrane part binding;calcium ion binding;cation binding;ion binding;metal ion binding;protein binding biological adhesion;cell adhesion;cell-cell adhesion;cellular process;homophilic cell adhesion 10 10 10 10.5 10.5 10.5 122.29 1.2339E-45 46802000 22413000 24389000 2144 IPI:IPI00028931.2 Desmoglein-2;HDGC DSG2;CDHF5 Q14126 ENST00000261590 K07597 1 0.90928 1.3067 NaN 1.1163 0.88855 NaN SAC3_GANP cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding DNA metabolic process;DNA replication;intracellular protein transport;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein import into nucleus;protein targeting;transport 3 3 3 2.4 2.4 2.4 218.4 2.7639E-07 7249600 3687100 3562500 2145 IPI:IPI00028954.1 80 kDa MCM3-associated protein;Protein GANP MCM3AP;GANP;KIAA0572;MAP80 O60318 ENST00000291688;ENST00000397708 1 0.56303 1.074 0.56205 0.74146 0.75206 0.69721 BOP1NT;WD40 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleolar part;nucleoplasm;organelle part;PeBoW complex;protein complex binding;protein binding maturation of LSU-rRNA;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA processing;rRNA processing 18 18 18 37.7 37.7 37.7 83.629 1.0583E-275 543950000 299710000 244230000 2146 IPI:IPI00028955.4 Ribosome biogenesis protein BOP1;Block of proliferation 1 protein BOP1;KIAA0124 Q14137 ENST00000307404 1 0.90627 1.6436 0.961 1.1464 1.1236 1.2873 U-box;Ufd2P_core cell part;intracellular part;macromolecular complex;protein complex;ubiquitin ligase complex binding;protein binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Ubiquitin mediated proteolysis 12 12 12 14.5 14.5 14.5 123.52 6.31E-219 185040000 94961000 90076000 2147 IPI:IPI00028957.2;IPI:IPI00556075.1 Ubiquitin conjugation factor E4 A UBE4A;KIAA0126 Q14139-2;Q14139;Q14139-1 ENST00000252108 K10596 2 0.49409 0.93511 0.4526 0.64816 0.60158 0.60826 Urb2 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part 18 18 18 13.6 13.6 13.6 170.54 8.5398E-192 51570000 29072000 22498000 2148 IPI:IPI00028980.2 Unhealthy ribosome biogenesis protein 2 homolog URB2;KIAA0133 Q14146 ENST00000258243 1 1.2083 1.6423 NaN 1.5693 1.0217 NaN FHA;Kinesin;PH cytoplasmic vesicle membrane;intracellular membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane;membrane-bounded organelle;microtubule;microtubule associated complex;mitochondrion;organelle;organelle membrane;vesicle membrane ATP binding;binding;catalytic activity;cytoskeletal protein binding;hydrolase activity;microtubule motor activity;motor activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity anterograde axon cargo transport;axon cargo transport;cell communication;cell-cell signaling;microtubule-based movement;microtubule-based process;nerve-nerve synaptic transmission;neuromuscular synaptic transmission;synaptic transmission;transport 4 4 2 2.1 2.1 1 205.14 9.1013E-10 1424200 900280 523900 2149 IPI:IPI00397383.2;IPI:IPI00029011.5;IPI:IPI00216252.5;IPI:IPI00411763.2 Kinesin-like protein KIF1B KIF1B;KIAA0591;KIAA1448 O60333-4;O60333;O60333-1;O60333-2 ENST00000263934;ENST00000355249;ENST00000377081;ENST00000377086;ENST00000377093 K10392 4 0.77598 1.4254 0.77913 0.98963 0.96603 1.0109 PCI cell part;cytoplasmic part;cytosol;eukaryotic translation initiation factor 3 complex;intracellular part;macromolecular complex;protein complex binding;nucleic acid binding;protein binding;structural molecule activity;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;formation of translation initiation complex;ribonucleoprotein complex assembly 50 50 50 33.1 33.1 33.1 166.57 0 4106700000 2162900000 1943800000 2150 IPI:IPI00029012.1 Eukaryotic translation initiation factor 3 subunit A;Eukaryotic translation initiation factor 3 subunit 10;eIF-3-theta;eIF3 p167;eIF3 p180;eIF3 p185 EIF3A;EIF3S10;KIAA0139 Q14152 ENST00000369144 K03254 1 0.76179 1.6225 0.62748 1.1049 1.0498 0.90035 adh_short cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;extracellular region part;extracellular space;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part 3-dehydrosphinganine reductase activity;binding;catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor metabolic process;oxidation reduction Sphingolipid metabolism 2 2 2 9 9 9 36.187 1.4717E-15 21985000 12687000 9298000 2151 IPI:IPI00029015.1 3-ketodihydrosphingosine reductase;3-dehydrosphinganine reductase;Follicular variant translocation protein 1 KDSR;FVT1 Q06136 ENST00000326575;ENST00000406396 K04708 1 0.7967 1.4989 0.79386 1.0849 0.97 1.052 UBA binding;protein binding 13 13 13 18 18 18 114.53 0 650310000 337620000 312690000 2152 IPI:IPI00514856.4;IPI:IPI00181306.3;IPI:IPI00029019.7;IPI:IPI00946257.1 Ubiquitin-associated protein 2-like;Protein NICE-4 UBAP2L;KIAA0144;NICE4 Q14157-2;Q14157;Q14157-3;Q14157-1;Q14157-4 ENST00000271877;ENST00000361546 4 0.8096 1.9753 0.87492 1.1061 1.2223 1.1988 cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part binding;carbohydrate binding carbohydrate metabolic process;metabolic process;primary metabolic process 12 12 12 46.2 46.2 46.2 32.233 0 441460000 231770000 209690000 2153 IPI:IPI00029046.1 Malectin MLEC;KIAA0152 Q14165 ENST00000228506 1 0.62888 1.2819 0.64085 0.81893 0.84997 0.80757 TTL acid-amino acid ligase activity;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;tubulin-tyrosine ligase activity biopolymer metabolic process;biopolymer modification;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;protein metabolic process;protein modification process 24 24 24 53.6 53.6 53.6 74.403 0 1192900000 637220000 555650000 2154 IPI:IPI00029048.2 Tubulin--tyrosine ligase-like protein 12 TTLL12;KIAA0153 Q14166 ENST00000216129 1 0.62428 1.5059 0.79602 0.87357 0.94714 1.0042 5_nucleotid cell part;cytoplasmic part;cytosol;intracellular part 5'-nucleotidase activity;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;ion binding;magnesium ion binding;nucleotidase activity;nucleotide binding;phosphatase activity;phosphoric ester hydrolase activity cellular metabolic process;cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;nucleotide metabolic process Nicotinate and nicotinamide metabolism;Purine metabolism;Pyrimidine metabolism 13 13 13 28.9 28.9 28.9 64.969 9.0965E-89 103880000 64657000 39219000 2155 IPI:IPI00029054.1 Cytosolic purine 5'-nucleotidase;5'-nucleotidase cytosolic II NT5C2;NT5B;NT5CP;PNT5 P49902 ENST00000343289;ENST00000404739 K01081 1 0.86266 1.5274 0.791 1.1155 1.0428 1.0096 AIRS;AIRS_C ATP binding;binding;catalytic activity;GTP binding;kinase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;selenide, water dikinase activity;selenium binding;transferase activity biopolymer metabolic process;biopolymer modification;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;protein metabolic process;protein modification process Selenoamino acid metabolism 8 8 8 33.7 33.7 33.7 42.91 5.2483E-227 251170000 127540000 123630000 2156 IPI:IPI00029056.2 Selenide, water dikinase 1;Selenophosphate synthetase 1;Selenium donor protein 1 SEPHS1;SELD;SPS;SPS1 P49903 ENST00000327347 K01008 1 0.61608 1.2009 0.60382 0.83548 0.78441 0.80437 ExsB;GATase;GMP_synt_C cell part;cytoplasm;intracellular part ATP binding;binding;catalytic activity;GMP synthase (glutamine-hydrolyzing) activity;GMP synthase activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleoside binding;nucleotide binding;purine nucleoside binding GMP biosynthetic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;purine base metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process Drug metabolism - other enzymes;Glutamate metabolism;Purine metabolism 38 38 38 62.9 62.9 62.9 76.715 0 3603200000 2030800000 1572500000 2157 IPI:IPI00029079.5 GMP synthase [glutamine-hydrolyzing];Glutamine amidotransferase;GMP synthetase GMPS P49915 ENST00000295920 K01951 1 0.8045 1.3967 0.7525 1.0372 0.93194 1.0089 DNA_ligase_A_C;DNA_ligase_A_M;DNA_ligase_A_N;zf-PARP cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part ATP binding;binding;catalytic activity;DNA binding;DNA ligase (ATP) activity;DNA ligase activity;ligase activity;magnesium ion binding;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;zinc ion binding DNA metabolic process;DNA recombination;DNA repair;DNA replication;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to DNA damage stimulus;response to stress Base excision repair 12 12 12 12.5 12.5 12.5 112.91 1.8535E-59 205300000 110070000 95227000 2158 IPI:IPI00029081.3;IPI:IPI00000156.3 DNA ligase 3;DNA ligase III;Polydeoxyribonucleotide synthase [ATP] 3 LIG3 P49916-1;P49916;P49916-2 ENST00000262327;ENST00000378526 K10776 2 NaN NaN 0.57037 NaN NaN 0.79855 DP;E2F_TDP cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex binding;DNA binding;nucleic acid binding;protein binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor activity;transcription factor binding;transcription regulator activity cell cycle;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription Cell cycle;TGF-beta signaling pathway 2 2 2 10 10 10 45.07 0.00024652 81796000 42401000 39395000 2159 IPI:IPI00029095.1 Transcription factor Dp-1;E2F dimerization partner 1;DRTF1-polypeptide 1 TFDP1;DP1 Q14186 ENST00000375370 K04683 1 0.34018 NaN 0.51672 0.45564 NaN 0.68381 3_5_exonuc;DEAD;Helicase_C;HRDC;RQC centrosome;cytoplasmic part;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;microtubule organizing center;non-membrane-bounded organelle;nuclear part;nucleolus;nucleoplasm;organelle;organelle part ATP-dependent DNA helicase activity;bubble DNA binding;catalytic activity;DNA binding;DNA helicase activity;DNA secondary structure binding;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;Y-form DNA binding base-excision repair;DNA metabolic process;DNA recombination;DNA repair;DNA replication;DNA synthesis during DNA repair;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;telomere maintenance 3 3 3 2.4 2.4 2.4 162.49 3.0567E-12 519470 460520 58947 2160 IPI:IPI00029107.1 Werner syndrome ATP-dependent helicase WRN;RECQ3;RECQL2 Q14191 ENST00000298139 K10900 1 0.80776 1.6467 0.74713 0.98714 1.1575 0.93148 RF-1 binding;nucleic acid binding;translation factor activity, nucleic acid binding;translation regulator activity;translation release factor activity;translation termination factor activity cellular component disassembly;cellular component organization;cellular macromolecular complex disassembly;cellular macromolecular complex subunit organization;cellular process;macromolecular complex disassembly;translational termination 3 3 3 16.5 16.5 16.5 23.63 1.2847E-15 102020000 53435000 48586000 2161 IPI:IPI00029114.1 Immature colon carcinoma transcript 1 protein;Digestion substraction 1 ICT1;DS1 Q14197 ENST00000301585 1 0.72849 1.7215 0.80581 0.93529 1.0985 1.0307 Mt_ATP-synt_B intracellular part;macromolecular complex;mitochondrial matrix;mitochondrial proton-transporting ATP synthase complex, coupling factor F(o);organelle part;protein complex;proton-transporting two-sector ATPase complex, proton-transporting domain binding;cation transmembrane transporter activity;hydrogen ion transmembrane transporter activity;ion transmembrane transporter activity;monovalent inorganic cation transmembrane transporter activity;protein binding;transporter activity ATP biosynthetic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;transport Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 18 18 18 52.7 52.7 52.7 28.908 2.7854E-203 1277800000 681240000 596590000 2162 IPI:IPI00029133.4 ATP synthase subunit b, mitochondrial ATP5F1 P24539 ENST00000369722 K02127 1 0.73266 1.3911 0.71369 0.92919 0.97742 0.89195 Strumpellin cell death;cellular process;death 11 11 11 13.1 13.1 13.1 134.28 2.5563E-242 41972000 22617000 19355000 2163 IPI:IPI00029175.5 Strumpellin KIAA0196 Q12768 ENST00000318410;ENST00000377985 1 NaN 1.1207 NaN NaN 0.69798 NaN C1_1;Pkinase;Pkinase_C cell part;intracellular ATP binding;binding;catalytic activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein kinase C activity;protein serine/threonine kinase activity;purine nucleoside binding;zinc ion binding cell communication;membrane protein ectodomain proteolysis;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;proteolysis;regulation of cell growth;signal transduction Tight junction;Vascular smooth muscle contraction 2 2 2 4.1 4.1 4.1 81.864 2.0122E-15 1081600 506270 575300 2164 IPI:IPI00029196.6;IPI:IPI00470691.2 Protein kinase C theta type;nPKC-theta PRKCQ;PRKCT Q04759-1;Q04759;Q04759-2 ENST00000263125;ENST00000397176;ENST00000397178 K06068 2 0.27616 0.39739 11.015 0.37674 0.24391 14.03 FCH;Pkinase_Tyr;SH2 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;kinase activity;non-membrane spanning protein tyrosine kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein tyrosine kinase activity;purine nucleoside binding cell communication;cellular process;intracellular signaling cascade;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein modification process;signal transduction 6 6 6 6.7 6.7 6.7 94.637 3.7914E-22 144520000 16424000 128100000 2166 IPI:IPI00029263.2;IPI:IPI00294344.2 Proto-oncogene tyrosine-protein kinase FER;p94-FER;Tyrosine kinase 3 FER;TYK3 P16591 ENST00000281092 K08889 2 0.70594 1.4353 0.71716 0.90494 0.99499 0.87668 Cytochrom_C1 cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part binding;cation binding;electron carrier activity;electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity;heme binding;ion binding;iron ion binding;metal ion binding cellular metabolic process;cellular process;electron transport chain;establishment of localization;generation of precursor metabolites and energy;metabolic process;oxidation reduction;transport Alzheimer's disease;Cardiac muscle contraction;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 7 7 7 27.4 27.4 27.4 35.39 9.525E-64 467620000 321480000 146140000 2167 IPI:IPI00029264.3 Cytochrome c1, heme protein, mitochondrial;Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit;Cytochrome b-c1 complex subunit 4;Complex III subunit 4;Complex III subunit IV CYC1 P08574 ENST00000318911 K00413 1 0.76603 1.5263 0.85627 1.0177 0.96381 1.1138 LSM cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;ribonucleoprotein complex;small nuclear ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;protein binding;RNA binding anatomical structure formation;cellular component assembly;cellular component organization;cellular process;ribonucleoprotein complex assembly;ribonucleoprotein complex biogenesis;spliceosomal snRNP biogenesis;spliceosome assembly 3 3 3 56.5 56.5 56.5 10.803 1.352E-169 539230000 284360000 254870000 2168 IPI:IPI00029266.1;IPI:IPI00068430.1 Small nuclear ribonucleoprotein E;Putative small nuclear ribonucleoprotein polypeptide E-like protein 1 SNRPE;SNRPEL1 P62304;Q5VYJ4 ENST00000338402 K11097 2 0.80915 1.4903 0.863 1.0473 0.98237 1.1672 RRM_1 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;small nuclear ribonucleoprotein complex;U2 snRNP binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 6 4 4 28.9 22.2 22.2 25.486 4.0888E-38 328690000 164840000 163850000 2169 IPI:IPI00029267.1 U2 small nuclear ribonucleoprotein B'' SNRPB2 P08579 ENST00000246071;ENST00000377943 K11094 1 0.53819 1.2479 0.53353 0.75139 0.76867 0.71934 4 4 4 7.1 7.1 7.1 69.65 1.9156E-11 17135000 9530300 7604300 2171 IPI:IPI00029372.2 HAUS augmin-like complex subunit 3 HAUS3;C4orf15 Q68CZ6 ENST00000243706 1 0.65866 1.465 0.78828 0.87978 0.97387 1.055 zf-RanBP cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;RNA binding;transcription factor activity;transcription regulator activity;transition metal ion binding;zinc ion binding cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 3 3 3 9.4 9.4 9.4 37.404 3.8561E-15 166340000 85250000 81094000 2172 IPI:IPI00029400.2;IPI:IPI00219866.2 Zinc finger Ran-binding domain-containing protein 2;Zinc finger protein 265;Zinc finger, splicing ZRANB2;ZIS;ZNF265 O95218-1;O95218;O95218-2 ENST00000254821;ENST00000340681;ENST00000370920 2 0.59177 1.7122 NaN 0.74315 1.2022 NaN PX cell part;cytoplasm;intracellular part binding;lipid binding;phosphoinositide binding;phospholipid binding;protein binding cell communication;cellular component organization;cellular process;endocytosis;establishment of localization;establishment of protein localization;membrane invagination;membrane organization;protein transport;transport;vesicle-mediated transport 2 2 2 4.2 4.2 4.2 51.908 9.1339E-06 2666700 1172600 1494100 2173 IPI:IPI00029403.1 Sorting nexin-4 SNX4 O95219 ENST00000251775 1 1.0269 1.9261 1.0131 1.3621 1.3772 1.2838 Kinesin cytoplasmic part;cytoskeletal part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;microtubule;nuclear part;nucleoplasm;organelle;organelle part ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;microtubule motor activity;motor activity;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity;transporter activity cellular process;establishment of localization;establishment of protein localization;microtubule-based movement;microtubule-based process;protein transport;transport;vesicle-mediated transport 7 7 7 9.9 9.9 9.9 100.28 1.1316E-23 23025000 12393000 10631000 2174 IPI:IPI00029422.1 Kinesin-like protein KIF20A;Rabkinesin-6;Rab6-interacting kinesin-like protein;GG10_2 KIF20A;RAB6KIFL O95235 ENST00000230902;ENST00000394894 K10402 1 0.74513 1.382 0.75494 0.90628 0.97333 0.9094 UPF0160 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;nucleus;organelle pigmentation 11 11 11 33 33 33 42.445 2.9881E-133 1022600000 531600000 491050000 2175 IPI:IPI00029444.1 UPF0160 protein MYG1, mitochondrial C12orf10 Q9HB07 ENST00000267103 1 1.0158 2.2596 1.1274 1.3864 1.3601 1.5674 V-SNARE cytoplasmic part;Golgi apparatus part;Golgi membrane;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;macromolecular complex;membrane;membrane part;organelle membrane;organelle part;protein complex;SNARE complex binding;protein binding;SNAP receptor activity cellular process;endosome transport;establishment of protein localization;intracellular protein transport;intra-Golgi vesicle-mediated transport;protein transport;retrograde transport, endosome to Golgi;transport;vesicle-mediated transport SNARE interactions in vesicular transport 4 4 4 21.2 21.2 21.2 28.612 5.2848E-13 110400000 56499000 53905000 2176 IPI:IPI00029447.5 Golgi SNAP receptor complex member 1;28 kDa Golgi SNARE protein;28 kDa cis-Golgi SNARE p28 GOSR1;GS28 O95249 ENST00000225724 K08495 1 0.82097 1.6655 0.80225 1.0869 1.1086 1.0567 Actin centrosome;dynactin complex;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;microtubule associated complex;microtubule organizing center;non-membrane-bounded organelle;organelle;organelle part;protein complex adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cellular process;establishment of localization;transport;vesicle-mediated transport 17 17 12 56.4 56.4 40.7 42.613 0 1200600000 624060000 576540000 2177 IPI:IPI00029468.1 Alpha-centractin;Centrosome-associated actin homolog;Actin-RPV;ARP1 ACTR1A;CTRN1 P61163 ENST00000369905 1 NaN NaN 0.94775 NaN NaN 1.1718 Actin centrosome;dynactin complex;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;microtubule associated complex;microtubule organizing center;non-membrane-bounded organelle;organelle;organelle part;protein complex adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding 7 2 2 24.2 8.5 8.5 42.293 7.6597E-75 6501400 2478400 4022900 2178 IPI:IPI00029469.1 Beta-centractin;Actin-related protein 1B ACTR1B;CTRN2 P42025 ENST00000289228 1 0.78198 1.6198 NaN 1.0914 0.99804 NaN cell part;cytoplasmic part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle gamete generation;male gamete generation;reproductive process;spermatogenesis 7 7 6 16.2 16.2 14.6 44.621 1.8159E-77 54607000 30513000 24094000 2179 IPI:IPI00029473.5 Protein Njmu-R1 C17orf75 Q9HAS0 ENST00000225805 1 0.31963 0.59247 0.28882 0.40695 0.42173 0.35631 zf-FCS cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding developmental process;multicellular organismal development;multicellular organismal process 2 1 1 1.9 1.2 1.2 152.38 4.5596E-30 6197500 3591200 2606200 2180 IPI:IPI00029484.1;IPI:IPI00219027.1 Zinc finger MYM-type protein 3;Zinc finger protein 261 ZMYM3;DXS6673E;KIAA0385;ZNF261 Q14202-1;Q14202;Q14202-2 ENST00000314425;ENST00000353904;ENST00000373988 2 0.8719 1.5824 0.91573 1.1432 1.0591 1.1818 CAP_GLY cell part;cytoplasm;cytoskeletal part;dynein complex;intracellular organelle part;intracellular part;macromolecular complex;microtubule;microtubule associated complex;organelle part;protein complex;spindle pole binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;motor activity;protein binding;pyrophosphatase activity cell cycle phase;cell cycle process;cell death;cellular component organization;cellular process;death;developmental process;mitosis;nervous system development;nuclear division;organelle fission;organelle organization;system development 36 36 35 34.7 34.7 34.3 141.69 0 1129800000 590790000 538990000 2181 IPI:IPI00029485.2;IPI:IPI00219114.1 Dynactin subunit 1;150 kDa dynein-associated polypeptide;DAP-150;p150-glued;p135 DCTN1 Q14203-1;Q14203;Q14203-2 ENST00000361874;ENST00000394003 2 0.59783 1.1967 0.62208 0.76531 0.76771 0.80933 NUC153 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part 15 15 15 28.3 28.3 28.3 80.301 1.0637E-163 174570000 93538000 81037000 2182 IPI:IPI00029513.1;IPI:IPI00016494.2;IPI:IPI00640783.1 Nucleolar protein 10 NOL10 Q9BSC4-1;Q9BSC4;Q9BSC4-2 ENST00000263836;ENST00000345985;ENST00000381685 3 NaN 1.8163 NaN NaN 1.1605 NaN PH;WW binding;lipid binding;phosphatidylinositol binding;phosphoinositide binding;phospholipid binding;protein binding 2 2 2 2.1 2.1 2.1 134.59 4.8839E-05 826770 548200 278570 2183 IPI:IPI00409582.1;IPI:IPI00169401.2;IPI:IPI00029515.3;IPI:IPI00409583.1;IPI:IPI00409581.1 Pleckstrin homology domain-containing family A member 5;Phosphoinositol 3-phosphate-binding protein 2;PEPP-2 PLEKHA5;KIAA1686;PEPP2 Q9HAU0-4;Q9HAU0;Q9HAU0-2;Q9HAU0-1;Q9HAU0-5;Q9HAU0-3 ENST00000299275;ENST00000309364;ENST00000317589;ENST00000355397;ENST00000359180 5 0.51609 0.93962 0.51869 0.6954 0.62126 0.66173 GATase_2;Pribosyltran amidophosphoribosyltransferase activity;binding;catalytic activity;cation binding;ion binding;iron ion binding;magnesium ion binding;transferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring pentosyl groups nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;purine base metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process Glutamate metabolism;Purine metabolism 20 20 20 37.5 37.5 37.5 57.398 2.4406E-263 917160000 502560000 414600000 2184 IPI:IPI00029534.1 Amidophosphoribosyltransferase;Glutamine phosphoribosylpyrophosphate amidotransferase PPAT;GPAT Q06203 ENST00000264220 K00764 1 0.64558 1.5033 0.6591 0.93064 0.90284 0.88313 GrpE cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part adenyl nucleotide binding;adenyl-nucleotide exchange factor activity;binding;enzyme regulator activity;identical protein binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding cellular process;intracellular protein transport;metabolic process;mitochondrial transport;protein folding;protein import;protein metabolic process;protein targeting;protein targeting to mitochondrion;protein transport;transport 12 12 12 63.1 63.1 63.1 24.279 4.6032E-214 942800000 512390000 430410000 2185 IPI:IPI00029557.3 GrpE protein homolog 1, mitochondrial;Mt-GrpE#1;HMGE GRPEL1;GREPEL1 Q9HAV7 ENST00000264954 K03687 1 0.8432 1.5855 0.96783 1.1582 0.99227 1.1721 dNK cytoplasmic part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;mitochondrial matrix;mitochondrial part;mitochondrial respiratory chain complex I;NADH dehydrogenase complex;organelle part;protein complex ATP binding;binding;catalytic activity;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity;nucleoside binding;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;purine nucleoside binding cellular process;generation of precursor metabolites and energy;metabolic process;mitochondrial electron transport, NADH to ubiquinone;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transport Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 13 13 13 32.1 32.1 32.1 40.75 1.3826E-85 329520000 167900000 161620000 2186 IPI:IPI00029561.1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial;NADH-ubiquinone oxidoreductase 42 kDa subunit;Complex I-42kD NDUFA10 O95299 ENST00000252711;ENST00000307300 K03954 1 0.89692 1.6005 0.89503 1.1362 1.0685 1.1083 Proteasome;Proteasome_A_N cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;mitochondrion;nucleus;organelle;proteasome core complex;protein complex binding;catalytic activity;endopeptidase activity;hydrolase activity;nucleic acid binding;peptidase activity;protein binding;RNA binding;threonine-type endopeptidase activity;threonine-type peptidase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Proteasome 10 10 10 48.8 48.8 48.8 27.399 1.4074E-203 3245600000 1713900000 1531700000 2187 IPI:IPI00029623.1 Proteasome subunit alpha type-6;Proteasome iota chain;Macropain iota chain;Multicatalytic endopeptidase complex iota chain;27 kDa prosomal protein;PROS-27;p27K PSMA6;PROS27 P60900 ENST00000261479 K02730 1 0.84391 1.5353 0.98832 1.0624 1.0856 1.2456 efhand endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;membrane-enclosed lumen;organelle;organelle lumen;organelle part binding;calcium ion binding;cation binding;ion binding;metal ion binding;protein binding 2 2 2 7.3 7.3 7.3 36.876 7.6485E-07 50514000 25204000 25310000 2188 IPI:IPI00029628.1 Reticulocalbin-2;Calcium-binding protein ERC-55;E6-binding protein RCN2;ERC55 Q14257 ENST00000320963;ENST00000394885 1 0.69379 1.3618 0.6415 0.94071 0.8581 0.85761 SPRY;zf-C3HC4 adherens junction;cell junction;cell-substrate adherens junction;cell-substrate junction;cytoplasm;focal adhesion;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transcription factor activity;transcription regulator activity;transition metal ion binding;zinc ion binding 17 17 17 34.6 34.6 34.6 70.989 0 338120000 189660000 148460000 2189 IPI:IPI00029629.3 Tripartite motif-containing protein 25;Zinc finger protein 147;Estrogen-responsive finger protein;RING finger protein 147 TRIM25;EFP;RNF147;ZNF147 Q14258 ENST00000316881 K10652 1 0.84747 1.5377 0.91283 1.0736 1.0097 1.1857 ER cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding cell cycle;cellular metabolic process;cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside metabolic process;pyrimidine nucleoside metabolic process 4 4 4 47.1 47.1 47.1 12.259 2.4713E-103 2050600000 1057300000 993300000 2190 IPI:IPI00029631.1 Enhancer of rudimentary homolog ERH P84090 ENST00000216520 1 0.47459 0.81716 NaN 0.6 0.58248 NaN Pkinase_Tyr;SAM_2 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle catalytic activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;receptor signaling protein serine/threonine kinase activity activation of MAPK activity;activation of MAPKK activity;cell cycle checkpoint;DNA damage checkpoint;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;regulation of protein amino acid phosphorylation MAPK signaling pathway;Tight junction 10 10 2 22.9 22.9 5.7 51.582 1.6038E-60 37815000 20749000 17065000 2191 IPI:IPI00029643.3 Mitogen-activated protein kinase kinase kinase MLT;MLK-like mitogen-activated protein triple kinase;Sterile alpha motif- and leucine zipper-containing kinase AZK;Leucine zipper- and sterile alpha motif-containing kinase;Mixed lineage kinase-related kinase;Cervical cancer suppressor gene 4 protein;HCCS-4 MLTK;ZAK;HCCS4 Q9NYL2-2;Q9NYL2 ENST00000338983;ENST00000375213;ENST00000409176 K04424 1 0.81227 1.1573 0.72011 1.0367 0.82953 0.88551 Cob_adeno_trans cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle ATP binding;binding;catalytic activity;cob(I)yrinic acid a,c-diamide adenosyltransferase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;transferase activity biosynthetic process;metabolic process;nitrogen compound metabolic process;porphyrin biosynthetic process;porphyrin metabolic process;vitamin biosynthetic process;vitamin metabolic process;water-soluble vitamin metabolic process Porphyrin and chlorophyll metabolism 2 2 2 7.6 7.6 7.6 27.388 3.6909E-06 22946000 11827000 11119000 2193 IPI:IPI00029665.8 Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial;Cob(I)alamin adenosyltransferase;Methylmalonic aciduria type B protein MMAB Q96EY8 ENST00000266839 K00798 1 1.9324 3.8804 1.6967 2.4262 2.4465 2.1407 cell part;cytoplasm;intracellular part binding;protein binding biological adhesion;cell adhesion;cellular process 5 5 5 9.6 9.6 9.6 83.856 1.1488E-68 11676000 4729400 6946400 2194 IPI:IPI00029680.3 Trophinin-associated protein;Trophinin-assisting protein TROAP Q12815 ENST00000257909 1 NaN 0.3249 NaN NaN 0.19978 NaN MAGE cell part;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part binding;protein binding biological adhesion;cell adhesion;cell-cell adhesion;cellular process;developmental process;embryo implantation;homophilic cell adhesion 4 2 2 2 1.3 1.3 143.71 2.9956E-10 2060700 333330 1727300 2195 IPI:IPI00029683.3 Trophinin;MAGE-D3 antigen TRO;KIAA1114;MAGED3 Q12816 ENST00000173898 1 0.85426 1.3649 NaN 1.0487 0.95447 NaN SNF5 chromatin remodeling complex;chromosome;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nuclear chromosome;organelle;organelle part;protein complex;SWI/SNF complex binding;p53 binding;protein binding chromatin organization;chromatin remodeling;DNA metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 4 4 4 14.3 14.3 14.3 44.141 6.9018E-45 55954000 28306000 27648000 2196 IPI:IPI00029695.2;IPI:IPI00745019.1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;Integrase interactor 1 protein;BAF47 SMARCB1;INI1;SNF5L1 Q12824-1;Q12824;Q12824-2 ENST00000263121;ENST00000344921 K11648 2 0.62635 1.1518 0.64725 0.82294 0.77715 0.81763 RNase_PH;RNase_PH_C cytoplasm;exosome (RNase complex);intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nuclear exosome (RNase complex);nucleolus;organelle;organelle part;protein complex 3'-5' exonuclease activity;3'-5'-exoribonuclease activity;binding;catalytic activity;exonuclease activity;exoribonuclease activity;hydrolase activity;nuclease activity;nucleic acid binding;protein binding;ribonuclease activity;RNA binding cellular process;immune response;immune system process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 5 5 5 13.6 13.6 13.6 50.803 1.4568E-81 229730000 125810000 103920000 2197 IPI:IPI00029697.3;IPI:IPI00654592.3;IPI:IPI00845426.1;IPI:IPI00607722.2 Exosome complex exonuclease RRP45;Exosome component 9;Polymyositis/scleroderma autoantigen 1;Autoantigen PM/Scl 1;Polymyositis/scleroderma autoantigen 75 kDa;P75 polymyositis-scleroderma overlap syndrome-associated autoantigen EXOSC9;PMSCL1 Q06265-2;Q06265;Q06265-1;Q06265-4;Q06265-3 ENST00000243498;ENST00000379663 K03678 4 0.40935 NaN NaN 0.60687 NaN NaN FERM_M;Focal_AT;Pkinase_Tyr adherens junction;cell junction;cell-substrate adherens junction;cell-substrate junction;cytoplasm;cytoskeleton;focal adhesion;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle binding;catalytic activity;non-membrane spanning protein tyrosine kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein tyrosine kinase activity;purine nucleoside binding;signal transducer activity apoptosis;cell death;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein complex assembly;protein modification process;response to stress;signal complex assembly Calcium signaling pathway;Chemokine signaling pathway;GnRH signaling pathway;Leukocyte transendothelial migration;Natural killer cell mediated cytotoxicity 4 4 4 6.5 6.5 6.5 115.87 8.7705E-09 5911800 3541100 2370700 2199 IPI:IPI00029702.1;IPI:IPI00216435.1 Protein tyrosine kinase 2 beta;Focal adhesion kinase 2;Proline-rich tyrosine kinase 2;Cell adhesion kinase beta;Calcium-dependent tyrosine kinase;Related adhesion focal tyrosine kinase PTK2B;FAK2;PYK2;RAFTK Q14289-1;Q14289;Q14289-2 ENST00000346049;ENST00000397501 K05871 2 0.59978 1.3529 0.57258 0.81822 0.85533 0.74824 Spc97_Spc98 centrosome;cytoplasmic microtubule;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;microtubule;microtubule organizing center;non-membrane-bounded organelle;organelle;organelle part;spindle pole anatomical structure formation;cellular component organization;cellular process;cytoskeleton organization;microtubule cytoskeleton organization;microtubule nucleation;microtubule-based process;organelle organization;protein complex assembly 16 16 16 23.6 23.6 23.6 102.53 1.0056E-115 119700000 60871000 58826000 2200 IPI:IPI00029705.2 Gamma-tubulin complex component 2;Spindle pole body protein Spc97 homolog TUBGCP2;GCP2 Q9BSJ2 ENST00000252936;ENST00000368563 1 0.55857 1.0718 0.60333 0.6866 0.71958 0.7648 DEAD_2;DUF1227 cell part;holo TFIIH complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex ATP-dependent DNA helicase activity;binding;catalytic activity;DNA binding;DNA helicase activity;helicase activity;iron ion binding;magnesium ion binding;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding cell cycle checkpoint;DNA catabolic process, endonucleolytic;DNA metabolic process;DNA repair;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleotide-excision repair, DNA damage removal;system process Nucleotide excision repair 9 9 9 13.7 13.7 13.7 86.908 9.3615E-52 50201000 27889000 22312000 2202 IPI:IPI00029728.3 TFIIH basal transcription factor complex helicase subunit;DNA repair protein complementing XP-D cells;Xeroderma pigmentosum group D-complementing protein;CXPD;DNA excision repair protein ERCC-2 ERCC2;XPD;XPDC P18074 ENST00000221481;ENST00000391945 K10844 1 0.6363 1.6072 0.71648 0.86033 1.0393 0.9354 SNARE;Syntaxin basolateral plasma membrane;cytosol;extracellular matrix;extracellular region part;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane-bounded organelle;organelle;vacuole binding;protein binding;SNAP receptor activity cellular process;establishment of localization;establishment of protein localization;intracellular protein transport;intracellular transport;neurotransmitter transport;protein transport;transport;vesicle-mediated transport SNARE interactions in vesicular transport 3 3 3 12.8 12.8 12.8 34.18 5.0624E-11 53060000 27884000 25175000 2203 IPI:IPI00029730.1 Syntaxin-4;Renal carcinoma antigen NY-REN-31 STX4;STX4A Q12846 ENST00000313843 K08486 1 0.73174 1.3124 0.77416 0.99194 0.91486 0.99358 Ribosomal_L35Ae cell part;cytoplasmic part;cytosol;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome binding;nucleic acid binding;protein binding;RNA binding;structural constituent of ribosome;structural molecule activity;tRNA binding biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA processing;rRNA processing;translational elongation Ribosome 7 7 7 29.1 29.1 29.1 12.538 2.1806E-40 1960300000 1033000000 927310000 2204 IPI:IPI00029731.8 60S ribosomal protein L35a;Cell growth-inhibiting gene 33 protein RPL35A;GIG33 P18077 ENST00000329092 K02917 1 0.67743 1.2324 0.63077 0.89491 0.79234 0.84793 AMP-binding cell fraction;endoplasmic reticulum membrane;insoluble fraction;integral to membrane;intrinsic to membrane;membrane;membrane fraction;microsome;mitochondrial outer membrane;organelle membrane;outer membrane;peroxisomal membrane;plasma membrane ATP binding;binding;catalytic activity;fatty-acid ligase activity;ligase activity;ligase activity, forming carbon-sulfur bonds;long-chain-fatty-acid-CoA ligase activity;magnesium ion binding;nucleoside binding;nucleotide binding;purine nucleoside binding behavior;carboxylic acid metabolic process;cellular process;fatty acid metabolic process;learning or memory;lipid metabolic process;metabolic process;multicellular organismal process;organic acid metabolic process;system process Adipocytokine signaling pathway;Fatty acid metabolism;PPAR signaling pathway 17 14 14 27.7 22.8 22.8 79.187 1.5626E-204 261590000 143970000 117620000 2206 IPI:IPI00029737.1;IPI:IPI00219897.1 Long-chain-fatty-acid--CoA ligase 4;Long-chain acyl-CoA synthetase 4 ACSL4;ACS4;FACL4;LACS4 O60488-1;O60488;O60488-2 ENST00000340800;ENST00000348502;ENST00000372078;ENST00000407441 K01897 2 0.8093 1.6292 0.82719 1.0777 1.0499 1.0706 SSB cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial nucleoid;mitochondrial part;nucleoid;organelle part binding;DNA binding;nucleic acid binding;single-stranded DNA binding;structure-specific DNA binding biosynthetic process;cellular process;DNA metabolic process;DNA replication;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process DNA replication;Homologous recombination;Mismatch repair 8 8 8 50.7 50.7 50.7 17.259 2.2079E-192 1533600000 826540000 707080000 2207 IPI:IPI00029744.1 Single-stranded DNA-binding protein, mitochondrial;PWP1-interacting protein 17 SSBP1;SSBP Q04837 ENST00000265304 K03111 1 0.7174 1.3434 0.70366 0.95213 0.8789 0.93914 Ribosomal_S24e cytosolic small ribosomal subunit;intracellular membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;nucleus;organelle;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit binding;nucleotide binding;protein binding;structural constituent of ribosome;structural molecule activity;translation initiation factor binding biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA processing;rRNA processing;translational elongation Ribosome 6 6 6 36.1 36.1 36.1 15.423 2.5659E-99 1776100000 937380000 838760000 2208 IPI:IPI00029750.1;IPI:IPI00847986.1 40S ribosomal protein S24 RPS24 P62847-1;P62847;P62847-2 ENST00000360830;ENST00000372360;ENST00000401656 K02974 2 0.50607 0.73953 0.44424 0.63612 0.50671 0.6281 DNA_mis_repair;HATPase_c cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle adenyl nucleotide binding;ATP binding;binding;DNA binding;double-stranded DNA binding;mismatched DNA binding;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding cell cycle;cellular process;DNA metabolic process;DNA repair;metabolic process;mismatch repair;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to DNA damage stimulus;response to stress Colorectal cancer;Endometrial cancer;Mismatch repair;Pathways in cancer 6 6 6 9.5 9.5 9.5 84.6 2.0408E-38 17557000 9963200 7593700 2209 IPI:IPI00029754.1 DNA mismatch repair protein Mlh1;MutL protein homolog 1 MLH1;COCA2 P40692 ENST00000231790 K08734 1 0.76504 1.505 0.76545 0.99955 0.96374 1.0208 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;catalytic activity;cation binding;ion binding;metal ion binding;nucleic acid binding;protein binding;RNA splicing factor activity, transesterification mechanism;transition metal ion binding;zinc ion binding anatomical structure formation;cellular component assembly;cellular component organization;cellular process;mRNA splice site selection;nuclear mRNA 3'-splice site recognition;ribonucleoprotein complex assembly 16 16 16 46.7 46.7 46.7 58.848 2.6101E-131 1515700000 793560000 722180000 2210 IPI:IPI00029764.1 Splicing factor 3A subunit 3;Spliceosome-associated protein 61;SF3a60 SF3A3;SAP61 Q12874 ENST00000373019 1 0.60041 0.79871 0.47968 0.75451 0.5378 0.61742 DHO_dh;Fer4;Pyr_redox_2 cell part;cytoplasmic part;cytosol;intracellular part binding;catalytic activity;dihydroorotate dehydrogenase activity;dihydroorotate oxidase activity;dihydrouracil dehydrogenase (NAD+) activity;iron ion binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding 'de novo' pyrimidine base biosynthetic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;purine base catabolic process;purine base metabolic process;pyrimidine base catabolic process;pyrimidine base metabolic process beta-Alanine metabolism;Drug metabolism - other enzymes;Pantothenate and CoA biosynthesis;Pyrimidine metabolism 3 3 3 3 3 3 111.4 9.818E-06 6299900 3601200 2698700 2211 IPI:IPI00029772.2 Dihydropyrimidine dehydrogenase [NADP+];Dihydrouracil dehydrogenase;Dihydrothymine dehydrogenase DPYD Q12882 ENST00000370192 K00207 1 0.84298 1.4858 1.0042 1.0039 1.0437 1.2401 RHD;TIG cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;protein binding;transcription factor activity;transcription regulator activity biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 5 5 5 9.2 9.2 9.2 68.519 2.3877E-12 46841000 25844000 20997000 2212 IPI:IPI00029773.1 C-Rel proto-oncogene protein REL Q04864 ENST00000295025 K09254 1 0.47952 0.99614 0.41998 0.67784 0.69702 0.56905 53-BP1_Tudor;BRCT condensed chromosome kinetochore;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;kinetochore;macromolecular complex;non-membrane-bounded organelle;nucleoplasm;organelle;organelle part;protein complex binding;protein binding;transcription activator activity;transcription regulator activity DNA metabolic process;DNA repair;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;response to DNA damage stimulus;response to stress;transcription 7 7 7 4.9 4.9 4.9 214.11 6.4115E-41 28106000 15894000 12211000 2213 IPI:IPI00742743.1;IPI:IPI00029778.3 Tumor suppressor p53-binding protein 1 TP53BP1 Q12888-2;Q12888;Q12888-1 ENST00000263801;ENST00000382044;ENST00000404183 2 NaN 1.2271 NaN NaN 0.7852 NaN MMR_HSR1 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding 2 2 2 6 6 6 37.236 0.00013829 10977000 6024800 4951900 2214 IPI:IPI00029803.5;IPI:IPI00396222.4 Mitochondrial GTPase 1;GTP-binding protein 7 MTG1;GTPBP7 Q9BT17-1;Q9BT17;Q9BT17-2 ENST00000317502 2 0.54699 1.1065 0.53766 0.73956 0.72055 0.72124 Mnd1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding cell cycle phase;cell cycle process;cellular process;DNA metabolic process;DNA recombination;meiosis;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 4 4 4 20 20 20 23.753 8.6856E-13 28266000 15123000 13143000 2215 IPI:IPI00029810.1 Meiotic nuclear division protein 1 homolog MND1;GAJ Q9BWT6 ENST00000240488 1 0.25056 0.43831 0.23166 0.31063 0.29474 0.28772 WD40 4 4 4 17.4 17.4 17.4 35.891 5.619E-68 56537000 35106000 21431000 2216 IPI:IPI00029811.5 WD repeat-containing protein 54 WDR54 Q9H977 ENST00000348227;ENST00000393990 1 0.71938 1.395 NaN 1.0047 0.92447 NaN cytoplasmic vesicle;intracellular organelle;intracellular part;lysosomal lumen;lysosomal membrane;membrane;membrane-enclosed lumen;organelle;organelle lumen;organelle membrane;organelle part;plasma membrane;vacuolar lumen;vacuolar membrane;vesicle alpha-sialidase activity;binding;catalytic activity;exo-alpha-sialidase activity;hydrolase activity;hydrolase activity, acting on glycosyl bonds;hydrolase activity, hydrolyzing O-glycosyl compounds;protein binding metabolic process Other glycan degradation;Sphingolipid metabolism 2 2 2 6 6 6 45.467 0.0026722 3860800 2195600 1665200 2217 IPI:IPI00029817.1 Sialidase-1;Lysosomal sialidase;N-acetyl-alpha-neuraminidase 1;Acetylneuraminyl hydrolase;G9 sialidase NEU1;NANH Q99519 ENST00000229725;ENST00000375631;ENST00000383183 K01186 1 0.81424 1.6174 0.8154 1.0084 1.1052 1.0215 Glucosamine_iso 6-phosphogluconolactonase activity;carboxylesterase activity;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds alcohol metabolic process;carbohydrate metabolic process;glucose catabolic process;glucose metabolic process;monosaccharide metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;pentose-phosphate shunt Pentose phosphate pathway 13 13 13 63.2 63.2 63.2 27.547 1.6787E-209 1714200000 838730000 875470000 2219 IPI:IPI00029997.1 6-phosphogluconolactonase PGLS O95336 ENST00000252603 K01057 1 0.43998 1.2938 0.53463 0.63508 0.81072 0.74183 Choline_kinase cell part;cytoplasm;intracellular part ATP binding;binding;catalytic activity;ethanolamine kinase activity;kinase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups alcohol metabolic process;biogenic amine metabolic process;cellular amino acid and derivative metabolic process;cellular amino acid derivative metabolic process;ethanolamine metabolic process;lipid metabolic process;phospholipid metabolic process Glycerophospholipid metabolism 8 8 8 17.9 17.9 17.9 50.968 3.3371E-33 131400000 77499000 53901000 2221 IPI:IPI00030090.1 Ethanolamine kinase 1 ETNK1;EKI1 Q9HBU6 ENST00000266517 K00894 1 0.75613 1.2356 0.73274 1.0807 0.79571 1.0412 XAP5 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle gamete generation;male gamete generation;reproductive process;spermatogenesis 8 8 8 20.9 20.9 20.9 40.241 1.5861E-36 247930000 127430000 120510000 2222 IPI:IPI00030098.5;IPI:IPI00015912.1 Protein FAM50A;Protein XAP-5;Protein HXC-26 FAM50A;DXS9928E;HXC26;XAP5 Q14320 ENST00000158526;ENST00000393600 2 0.7291 1.5402 0.80108 0.96145 1.0378 1.0044 LEM;Thymopoietin chromosome;integral to membrane;intracellular organelle;intrinsic to membrane;membrane;non-membrane-bounded organelle;nuclear inner membrane;nuclear membrane;organelle;organelle inner membrane;organelle membrane binding;DNA binding;lamin binding;nucleic acid binding;protein binding 20 10 10 43 20.9 20.9 50.67 0 959250000 499730000 459520000 2223 IPI:IPI00030131.3;IPI:IPI00181409.6 Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin, isoforms beta/gamma;Thymopoietin-related peptide isoforms beta/gamma;Thymopoietin;Splenin;Thymopentin;TP5 TMPO;LAP2 P42167-1;P42167;P42167-2 ENST00000261210;ENST00000266732;ENST00000343315;ENST00000393053 2 0.65577 1.1453 0.60411 0.83464 0.75219 0.75584 Beta-trefoil;LAG1-DNAbind;TIG cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;catalytic activity;DNA binding;nucleic acid binding;protein binding;recombinase activity;transcription factor activity;transcription regulator activity cell communication;DNA metabolic process;DNA recombination;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;signal transduction;transcription Notch signaling pathway 8 8 8 14.6 14.6 14.6 55.663 1.3622E-32 98403000 54512000 43890000 2224 IPI:IPI00030177.2;IPI:IPI00402156.2;IPI:IPI00419892.2;IPI:IPI00807402.1;IPI:IPI00218576.2;IPI:IPI00218578.2 Recombining binding protein suppressor of hairless;J kappa-recombination signal-binding protein;RBP-J kappa;CBF-1;Renal carcinoma antigen NY-REN-30 RBPJ;IGKJRB;IGKJRB1;RBPJK;RBPSUH Q06330-1;Q06330;Q06330-6;Q06330-4;Q06330-5;Q06330-2;Q06330-3 ENST00000342295;ENST00000345843;ENST00000348160;ENST00000355476;ENST00000361572 K06053 6 0.7215 1.2852 0.79463 0.96829 0.84727 1.0674 Ribosomal_L30;Ribosomal_L30_N cell part;cytoplasmic part;cytosolic large ribosomal subunit;cytosolic part;intracellular organelle part;intracellular part;large ribosomal subunit;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit binding;DNA binding;identical protein binding;mRNA binding;nucleic acid binding;protein binding;protein homodimerization activity;RNA binding;structural constituent of ribosome;structural molecule activity;transcription regulator activity biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA processing;rRNA processing;translational elongation Ribosome 19 18 18 53.2 50.8 50.8 29.225 0 11841000000 6170700000 5670100000 2225 IPI:IPI00030179.3 60S ribosomal protein L7 RPL7 P18124 ENST00000352983;ENST00000396470 K02937 1 0.78631 1.5201 0.82607 1.0429 0.9948 1.0946 cell part;cytoplasmic part;cytosol;intracellular part catalytic activity;guanidinoacetate N-methyltransferase activity;methyltransferase activity;S-adenosylmethionine-dependent methyltransferase activity;transferase activity;transferase activity, transferring one-carbon groups cellular amino acid and derivative metabolic process;cellular amino acid derivative metabolic process;creatine biosynthetic process;creatine metabolic process;muscle system process;organic acid metabolic process;phosphagen metabolic process;system process Arginine and proline metabolism;Glycine, serine and threonine metabolism 5 5 5 27.5 27.5 27.5 26.318 2.268E-211 51224000 28808000 22416000 2226 IPI:IPI00030182.1 Guanidinoacetate N-methyltransferase GAMT Q14353 ENST00000252288 K00542 1 0.63906 1.3095 0.59656 0.88179 0.8603 0.81552 Epimerase cell part;cytoplasm;intracellular part binding;carbon-oxygen lyase activity;catalytic activity;coenzyme binding;cofactor binding;GDP-mannose 4,6-dehydratase activity;hydro-lyase activity;lyase activity alcohol metabolic process;carbohydrate metabolic process;fucose metabolic process;L-fucose biosynthetic process;mannose metabolic process;monosaccharide metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Fructose and mannose metabolism 11 11 11 38.7 38.7 38.7 41.949 6.7184E-226 287810000 160760000 127050000 2227 IPI:IPI00030207.1 GDP-mannose 4,6 dehydratase;GDP-D-mannose dehydratase GMDS O60547 ENST00000380815 K01711 1 0.69759 1.4002 0.69059 0.92242 0.90429 0.955 PA28_alpha;PA28_beta cell part;cytoplasmic part;cytosol;intracellular part;macromolecular complex;proteasome activator complex;protein complex binding;identical protein binding;proteasome activator activity;proteasome regulator activity;protein binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Antigen processing and presentation;Proteasome 16 16 16 51.3 51.3 51.3 30.886 9.5519E-290 1901300000 1002900000 898370000 2228 IPI:IPI00219445.1;IPI:IPI00030243.1 Proteasome activator complex subunit 3;Proteasome activator 28 subunit gamma;Activator of multicatalytic protease subunit 3;11S regulator complex subunit gamma;Ki nuclear autoantigen PSME3 P61289-2;P61289;P61289-1 ENST00000293362 K06698 2 0.63857 1.3482 0.69782 0.84101 0.88443 0.89018 Cyclin_N cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;DNA binding;nucleic acid binding;protein binding nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of cyclin-dependent protein kinase activity;regulation of transcription, DNA-dependent;transcription;transcription, DNA-dependent 6 6 6 11.6 11.6 11.6 80.684 3.4135E-62 78589000 44312000 34277000 2229 IPI:IPI00030247.1 Cyclin-T1 CCNT1 O60563 ENST00000261900 1 NaN NaN 0.55493 NaN NaN 0.67604 DUF2305 5 5 5 17.8 17.8 17.8 37.318 1.2351E-30 28710000 14218000 14492000 2230 IPI:IPI00030257.3 UPF0554 protein C2orf43 C2orf43 Q9H6V9 ENST00000237822;ENST00000381090 1 0.68841 1.2798 0.67804 0.87994 0.8832 0.87939 HATPase_c;HSP90 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle adenyl nucleotide binding;ATP binding;binding;cytokine receptor binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;receptor binding;tumor necrosis factor receptor binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process;response to stress 29 29 29 48.9 48.9 48.9 80.109 0 2104900000 1119900000 984940000 2232 IPI:IPI00030275.5 Heat shock protein 75 kDa, mitochondrial;Tumor necrosis factor type 1 receptor-associated protein;TNFR-associated protein 1 TRAP1;HSP75 Q12931 ENST00000246957 K09488 1 0.35615 1.4095 NaN 0.59714 0.90326 NaN MATH;zf-C3HC4;zf-TRAF cell part;cytoplasmic part;cytosol;intracellular part binding;cation binding;ion binding;metal ion binding;molecular transducer activity;protein binding;signal transducer activity;transition metal ion binding;zinc ion binding positive regulation of cytokine production;positive regulation of immune system process;positive regulation of leukocyte activation;regulation of cytokine production;regulation of immune system process;regulation of leukocyte activation Adipocytokine signaling pathway;Apoptosis;MAPK signaling pathway;Pathways in cancer;Small cell lung cancer 3 3 3 7.6 7.6 7.6 61.383 4.1838E-07 4239600 2348100 1891500 2233 IPI:IPI00292635.1;IPI:IPI00030278.4 TNF receptor-associated factor 2;Tumor necrosis factor type 2 receptor-associated protein 3 TRAF2;TRAP3 Q12933-2;Q12933;Q12933-1 ENST00000247668 K03173 2 0.64661 1.085 0.25319 0.84451 0.75072 0.34017 DUF1605;HA2;Helicase_C cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex ATP binding;ATP-dependent helicase activity;binding;catalytic activity;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 3 3 3 4.6 4.6 4.6 78.909 4.8344E-34 18895000 11465000 7430400 2234 IPI:IPI00030288.2 Probable ATP-dependent RNA helicase DHX35;DEAH box protein 35 DHX35;C20orf15;DDX35 Q9H5Z1 ENST00000252011 1 0.79194 1.4314 0.80559 1.051 0.95957 1.0314 DEAD;Helicase_C cell part;cytoplasmic mRNA processing body;cytoplasmic part;intracellular part;macromolecular complex;ribonucleoprotein complex;stress granule ATP binding;ATP-dependent helicase activity;binding;catalytic activity;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity;RNA binding;RNA helicase activity 18 18 18 46.4 46.4 46.4 54.416 0 981740000 503810000 477920000 2235 IPI:IPI00030320.4 Probable ATP-dependent RNA helicase DDX6;DEAD box protein 6;ATP-dependent RNA helicase p54;Oncogene RCK DDX6;HLR2;RCK P26196 ENST00000264018 1 0.74562 1.4105 NaN 0.93775 0.97349 NaN Gua_kin_assoc_C;Guanylate_kin;L27_1;MAGUK_N_PEST;PDZ;PDZ_assoc;SH3_1 basolateral plasma membrane;cell junction;cell-cell junction;cytoskeletal part;endoplasmic reticulum membrane;intracellular part;membrane;membrane part;organelle membrane;organelle part;plasma membrane;postsynaptic density;sarcolemma auxiliary transport protein activity;binding;catalytic activity;cytoskeletal protein binding;guanylate kinase activity;phosphoprotein phosphatase activity;potassium channel regulator activity;protein binding;protein C-terminus binding actin filament organization;cell adhesion;cell cycle checkpoint;cytoskeleton organization;endothelial cell proliferation;establishment or maintenance of cell polarity;mitotic cell cycle checkpoint;organelle organization;regulation of mitotic cell cycle T cell receptor signaling pathway 2 2 2 2.1 2.1 2.1 103.32 0.000155 12737000 6577700 6159000 2236 IPI:IPI00218729.4;IPI:IPI00552376.2;IPI:IPI00030351.2;IPI:IPI00552511.2;IPI:IPI00552213.2;IPI:IPI00553029.2;IPI:IPI00552682.2 Disks large homolog 1;Synapse-associated protein 97;hDlg DLG1 Q12959-2;Q12959;Q12959-7;Q12959-1;Q12959-4;Q12959-6;Q12959-3;Q12959-5 ENST00000314062;ENST00000346964;ENST00000357674;ENST00000359922;ENST00000381807;ENST00000392382 K12076 7 NaN 2.0266 0.78031 NaN 1.2262 1.0558 PPI_Ypi1 cell fraction;cell part;soluble fraction binding;enzyme inhibitor activity;enzyme regulator activity;phosphatase inhibitor activity;phosphatase regulator activity;phosphoprotein phosphatase inhibitor activity;protein binding;protein phosphatase regulator activity 2 2 2 13.5 13.5 13.5 13.952 2.6147E-37 15020000 7241900 7777800 2238 IPI:IPI00030355.1 Protein phosphatase 1 regulatory subunit 11;Protein phosphatase inhibitor 3;Hemochromatosis candidate protein V;HCG V;HCG-V PPP1R11;HCGV;TCTE5 O60927 ENST00000230260;ENST00000376772;ENST00000383612 1 0.32702 0.67962 0.33092 0.44571 0.45609 0.44119 DHFR_1 binding;catalytic activity;dihydrofolate reductase activity;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on the CH-NH group of donors;oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;glycine biosynthetic process;glycine metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process Folate biosynthesis;One carbon pool by folate 7 7 7 46.5 46.5 46.5 21.452 4.5956E-80 163010000 89464000 73549000 2240 IPI:IPI00030357.7;IPI:IPI00219558.3 Dihydrofolate reductase DHFR;DHFRP1 P00374 ENST00000342938 K00287 2 0.70169 1.6366 NaN 0.88163 1.1694 NaN MARVEL cell fraction;endoplasmic reticulum membrane;endoplasmic reticulum part;insoluble fraction;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane fraction;membrane part;organelle membrane;organelle part;plasma membrane binding;chemokine binding;cytokine binding;ion transmembrane transporter activity;protein binding;substrate-specific transmembrane transporter activity;substrate-specific transporter activity;transmembrane transporter activity;transporter activity behavior;cell communication;cell surface receptor linked signal transduction;cellular process;chemotaxis;cytokine-mediated signaling pathway;ion transport;locomotion;locomotory behavior;response to external stimulus;signal transduction;transport 2 2 2 18.4 18.4 18.4 16.691 9.8192E-19 19945000 9751900 10193000 2241 IPI:IPI00030362.1 Proteolipid protein 2;Intestinal membrane A4 protein;Differentiation-dependent protein A4 PLP2;A4 Q04941 ENST00000376327 1 0.77346 1.6102 0.7829 1.0225 1.0366 1.0293 Thiolase_C;Thiolase_N cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part acetyl-CoA C-acetyltransferase activity;acetyltransferase activity;acyltransferase activity;binding;C-acetyltransferase activity;C-acyltransferase activity;catalytic activity;protein binding;transferase activity metabolic process Benzoate degradation via CoA ligation;Butanoate metabolism;Fatty acid metabolism;Lysine degradation;Propanoate metabolism;Pyruvate metabolism;Synthesis and degradation of ketone bodies;Tryptophan metabolism;Two-component system;Valine, leucine and isoleucine degradation 18 18 18 47.8 47.8 47.8 45.199 0 871460000 473400000 398060000 2242 IPI:IPI00030363.1 Acetyl-CoA acetyltransferase, mitochondrial;Acetoacetyl-CoA thiolase;T2 ACAT1;ACAT;MAT P24752 ENST00000265838 K00626 1 0.51533 1.3321 0.74271 0.72468 0.81353 0.98116 BSD;TFIIH_BTF_p62_N cell part;holo TFIIH complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex binding;catalytic activity;protein binding;protein kinase activity;protein serine/threonine kinase activity;RNA polymerase II carboxy-terminal domain kinase activity;RNA polymerase II transcription factor activity DNA catabolic process;DNA metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleotide-excision repair, DNA damage removal;regulation of cyclin-dependent protein kinase activity;RNA elongation;transcription initiation Basal transcription factors;Nucleotide excision repair 4 4 4 8.6 8.6 8.6 62.031 2.0083E-70 7678600 4245300 3433300 2244 IPI:IPI00030380.1 General transcription factor IIH subunit 1;General transcription factor IIH polypeptide 1;TFIIH basal transcription factor complex p62 subunit;Basic transcription factor 2 62 kDa subunit;BTF2-p62 GTF2H1;BTF2 P32780 ENST00000265963 K03141 1 0.88217 1.6373 0.79484 1.1297 1.1272 1.0647 FHA cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part;ribonucleoprotein complex;spliceosomal complex catalytic activity;DNA binding;endonuclease activity;enzyme inhibitor activity;magnesium ion binding;nuclease activity;nucleic acid binding;phosphoprotein phosphatase inhibitor activity;ribonuclease activity;RNA binding metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;RNA catabolic process;RNA processing;RNA splicing;transcription 8 8 8 25.9 25.9 25.9 38.478 2.7657E-80 129630000 67214000 62418000 2245 IPI:IPI00030383.1;IPI:IPI00142629.1;IPI:IPI00218794.1 Nuclear inhibitor of protein phosphatase 1;Protein phosphatase 1 regulatory inhibitor subunit 8;Activator of RNA decay;ARD-1 PPP1R8;ARD1;NIPP1 Q12972-1;Q12972;Q12972-2 ENST00000236412;ENST00000311772;ENST00000359986;ENST00000399116 K01128 3 NaN 1.4557 NaN NaN 0.90442 NaN C2;PH;RhoGAP;RhoGEF cell part;intracellular binding;enzyme activator activity;GTPase activator activity;guanyl-nucleotide exchange factor activity;protein binding;Ras guanyl-nucleotide exchange factor activity;Rho guanyl-nucleotide exchange factor activity;small GTPase regulator activity cell communication;cellular process;intracellular signaling cascade;regulation of cell communication;regulation of Rho protein signal transduction;regulation of signal transduction;signal transduction;small GTPase mediated signal transduction 3 2 2 4.5 3.4 3.4 97.696 6.0905E-11 1067100 601330 465750 2246 IPI:IPI00030389.1;IPI:IPI00298955.1 Active breakpoint cluster region-related protein ABR Q12979-1;Q12979;Q12979-2 ENST00000291107;ENST00000302538 2 0.36223 1.1079 0.61258 0.50587 0.6955 0.75172 Ank;Chromo cell part;chromatin;chromosomal part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;nucleus;organelle;organelle part binding;chromatin binding cell cycle;cellular component organization;cellular process;chromatin assembly or disassembly;chromatin organization;chromosome organization;organelle organization 4 4 4 6.1 6.1 6.1 97.635 1.0694E-93 39338000 20131000 19206000 2247 IPI:IPI00885104.1;IPI:IPI00030408.2 M-phase phosphoprotein 8;Two hybrid-associated protein 3 with RanBPM MPHOSPH8;MPP8 Q99549-2;Q99549;Q99549-1 ENST00000361479 2 0.8726 1.7878 NaN 1.126 1.1958 NaN Tmemb_55A cytoplasmic part;endosomal part;endosome membrane;integral to membrane;intracellular part;intrinsic to membrane;late endosome membrane;lysosomal membrane;membrane;membrane part;organelle membrane;organelle part;vacuolar membrane;vacuolar part catalytic activity;hydrolase activity 4 4 3 19 19 15.5 30.185 1.4802E-71 26961000 14783000 12178000 2248 IPI:IPI00332278.1;IPI:IPI00030530.6 Transmembrane protein 55B;Type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase;PtdIns-4,5-P2 4-Ptase I TMEM55B;C14orf9 Q86T03-2;Q86T03;Q86T03-1 ENST00000250489;ENST00000398020 2 0.83577 1.9115 0.72296 1.1417 1.2247 0.96669 FHA;Prefoldin_2 endoplasmic reticulum;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;macromolecular complex;membrane;organelle;plasma membrane;prefoldin complex;sarcolemma;smooth endoplasmic reticulum binding;protein binding;unfolded protein binding cellular biopolymer metabolic process;cellular process;macromolecule metabolic process;metabolic process;multicellular organismal process;muscle contraction;muscle system process;protein folding;protein metabolic process;system process 5 5 3 7 7 4.2 95.197 1.2946E-26 13645000 7493600 6151300 2249 IPI:IPI00791574.1;IPI:IPI00030531.4;IPI:IPI00794566.1;IPI:IPI00446339.2;IPI:IPI00432472.2;IPI:IPI00794462.1;IPI:IPI00795406.1 Sarcolemmal membrane-associated protein SLMAP;KIAA1601;SLAP;UNQ1847/PRO3577 Q14BN4-1;Q14BN4;Q14BN4-3;Q14BN4-2;Q14BN4-6;Q14BN4-7 ENST00000295951;ENST00000295952;ENST00000383718 7 0.75723 1.5329 0.77778 1.0619 0.95639 1.0984 SAPS cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;enzyme binding;phosphatase binding;protein binding;protein phosphatase binding regulation of cellular metabolic process;regulation of dephosphorylation;regulation of metabolic process;regulation of phosphatase activity;regulation of phosphate metabolic process;regulation of phosphoprotein phosphatase activity 11 11 11 17.3 17.3 17.3 98.484 3.5729E-128 280540000 145210000 135330000 2252 IPI:IPI00719725.1;IPI:IPI00719821.1;IPI:IPI00719553.1;IPI:IPI00030624.5;IPI:IPI00019540.1;IPI:IPI00719345.1 Serine/threonine-protein phosphatase 6 regulatory subunit 3;SAPS domain family member 3;Sporulation-induced transcript 4-associated protein SAPL SAPS3;C11orf23;KIAA1558;PP6R3;SAPL Q5H9R7-5;Q5H9R7;Q5H9R7-1;Q5H9R7-2;Q5H9R7-6;Q5H9R7-4;Q5H9R7-3 ENST00000265636;ENST00000265637;ENST00000393799;ENST00000393800;ENST00000393801 6 0.83252 1.2762 NaN 1.1074 0.88941 NaN BAG cell part;cytoplasm;intracellular part molecular transducer activity;receptor signaling protein activity;signal transducer activity anti-apoptosis;apoptosis;cell death;cellular biopolymer metabolic process;cellular process;death;metabolic process;programmed cell death;protein folding;protein metabolic process;regulation of apoptosis;regulation of cell death 2 2 2 5.3 5.3 5.3 49.593 8.2806E-14 1756900 958290 798610 2254 IPI:IPI00030695.1 BAG family molecular chaperone regulator 4;Bcl-2-associated athanogene 4;Silencer of death domains BAG4;SODD O95429 ENST00000287322 K09558 1 0.75274 1.5991 0.76454 1.0038 1.0681 0.96236 Iso_dh cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part binding;catalytic activity;isocitrate dehydrogenase (NAD+) activity;isocitrate dehydrogenase activity;magnesium ion binding;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors acetyl-CoA metabolic process;carbohydrate metabolic process;catabolic process;cellular metabolic process;cellular process;coenzyme catabolic process;coenzyme metabolic process;metabolic process;primary metabolic process;tricarboxylic acid cycle Citrate cycle (TCA cycle) 13 13 13 34.2 34.2 34.2 39.591 1.1419E-59 1064900000 570060000 494840000 2255 IPI:IPI00030702.1;IPI:IPI00792971.2 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial;Isocitric dehydrogenase;NAD(+)-specific ICDH IDH3A P50213-1;P50213;P50213-2 ENST00000299518 K00030 2 1.5954 3.0377 1.6736 2.0543 1.9761 2.1742 Aha1_N;AHSA1 cell part;cytoplasmic part;cytosol;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle ATPase activator activity;ATPase regulator activity;binding;chaperone binding;enzyme activator activity;enzyme regulator activity;nucleoside-triphosphatase regulator activity;protein binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process;response to stress 19 19 19 55.9 55.9 55.9 38.274 0 4048800000 1784000000 2264800000 2256 IPI:IPI00030706.1 Activator of 90 kDa heat shock protein ATPase homolog 1;p38 AHSA1;C14orf3;HSPC322 O95433 ENST00000216479 1 0.70528 1.4508 0.64472 0.91226 0.91434 0.85046 cell part;cytoplasmic part;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle binding;protein binding anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex assembly;cellular macromolecular complex subunit organization;cellular process;proteasome assembly;protein complex assembly 11 11 11 50 50 50 32.854 1.1164E-164 345280000 189730000 155550000 2257 IPI:IPI00030770.1;IPI:IPI00401072.1 Proteasome assembly chaperone 1;Down syndrome critical region protein 2;Chromosome 21 leucine-rich protein PSMG1;C21LRP;DSCR2;PAC1 O95456-1;O95456;O95456-2 ENST00000331573;ENST00000380900 K11875 2 0.90075 1.5417 0.84457 1.1911 1.0205 1.0832 SH2;STAT_alpha;STAT_bind;STAT_int cell part;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;calcium ion binding;DNA binding;hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity;nucleic acid binding;receptor signaling protein activity;signal transducer activity;transcription factor activity nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein modification process;regulation of transcription, DNA-dependent;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent Chemokine signaling pathway;Jak-STAT signaling pathway;Pancreatic cancer;Pathways in cancer;Toll-like receptor signaling pathway 24 24 24 36.1 36.1 36.1 87.334 0 797870000 423960000 373910000 2258 IPI:IPI00030781.1;IPI:IPI00218188.1 Signal transducer and activator of transcription 1-alpha/beta;Transcription factor ISGF-3 components p91/p84 STAT1 P42224-1;P42224;P42224-2 ENST00000361099;ENST00000409465 K11220 2 0.75067 1.1499 0.71734 0.94962 0.78714 0.96729 SH2;STAT_alpha;STAT_bind;STAT_int cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;calcium ion binding;cation binding;DNA binding;ion binding;metal ion binding;molecular transducer activity;nucleic acid binding;protein binding;signal transducer activity;transcription factor activity;transcription regulator activity biosynthetic process;cell communication;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;signal transduction;transcription Jak-STAT signaling pathway 6 6 6 7.7 7.7 7.7 94.134 1.0754E-31 41304000 22380000 18924000 2259 IPI:IPI00030782.1;IPI:IPI00792907.2 Signal transducer and activator of transcription 6;IL-4 Stat STAT6 P42226-1;P42226;P42226-2 ENST00000300134 K11225 2 0.74623 1.5307 0.73062 0.9841 0.95964 0.96629 MRP-L47 intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;mitochondrial ribosome;non-membrane-bounded organelle;organellar ribosome;organelle;organelle part;ribonucleoprotein complex;ribosome structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 5 5 5 20.4 20.4 20.4 29.45 2.7058E-15 64058000 36211000 27847000 2260 IPI:IPI00030820.2;IPI:IPI00794978.1;IPI:IPI00375687.6 39S ribosomal protein L47, mitochondrial;Nasopharyngeal carcinoma metastasis-related protein 1 MRPL47;NCM1;CGI-204 Q9HD33-1;Q9HD33;Q9HD33-2 ENST00000259038 3 0.51099 0.71872 0.72919 0.69293 0.51919 0.91215 Homeobox cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;sequence-specific DNA binding;transcription factor activity;transcription regulator activity anatomical structure morphogenesis;organ morphogenesis;regulation of biosynthetic process;regulation of gene expression;regulation of transcription, DNA-dependent;sensory perception;system process;visual perception 5 5 5 28.9 28.9 28.9 27.687 2.3897E-52 55421000 32745000 22675000 2261 IPI:IPI00030821.4;IPI:IPI00030013.1 Homeobox protein SIX6;Sine oculis homeobox homolog 6;Optic homeobox 2;Homeodomain protein OPTX2 SIX6;OPTX2;SIX9 O95475 ENST00000327720;ENST00000381716 2 0.8896 1.93 0.90907 1.1956 1.2524 1.239 EMP70 cell part;integral to membrane;intrinsic to membrane;membrane part binding 10 10 10 20.2 20.2 20.2 67.887 8.5909E-73 295150000 155330000 139820000 2262 IPI:IPI00030847.3 Transmembrane 9 superfamily member 3;SM-11044-binding protein;EP70-P-iso TM9SF3;SMBP;UNQ245/PRO282 Q9HD45 ENST00000371142 1 0.86768 1.4636 3.3996 1.1528 1.0043 4.3891 Gelsolin;Sec23_BS;Sec23_helical;Sec23_trunk;zf-Sec23_Sec24 COPII vesicle coat;endoplasmic reticulum membrane;endoplasmic reticulum part;Golgi apparatus part;intracellular part;macromolecular complex;membrane;membrane coat;membrane part;organelle membrane;organelle part;protein complex;vesicle coat binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;transporter activity;zinc ion binding cellular component organization;cellular process;ER to Golgi vesicle-mediated transport;establishment of protein localization;intracellular protein transport;membrane organization;protein transport;transport;vesicle-mediated transport 12 12 12 10.9 10.9 10.9 140.42 2.9976E-119 43870000 23564000 20306000 2263 IPI:IPI00030851.3;IPI:IPI00785208.1 Protein transport protein Sec24B;SEC24-related protein B SEC24B O95487-1;O95487;O95487-2 ENST00000265175 2 0.7152 1.9855 0.96326 0.93769 1.4098 1.1802 Sep15_SelM endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;membrane-enclosed lumen;organelle;organelle lumen;organelle part binding;selenium binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;'de novo' protein folding;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 2 2 2 16.4 16.4 16.4 18.045 0.0028728 34719000 16899000 17820000 2264 IPI:IPI00030877.2;IPI:IPI00409574.3 15 kDa selenoprotein SEP15 O60613-1;O60613;O60613-2 ENST00000331835 2 0.76564 1.9002 0.93737 0.99209 1.2565 1.2704 DUF1873;Rhodanese;UCH cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;cysteine-type endopeptidase activity;cysteine-type peptidase activity;endopeptidase activity;hydrolase activity;peptidase activity;protein binding;ubiquitin thiolesterase activity;ubiquitin-specific protease activity catabolic process;cell proliferation;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process 9 9 9 10.3 10.3 10.3 127.52 1.338E-138 61337000 33339000 27999000 2266 IPI:IPI00030915.1 Ubiquitin carboxyl-terminal hydrolase 8;Ubiquitin thioesterase 8;Ubiquitin-specific-processing protease 8;Deubiquitinating enzyme 8 USP8;KIAA0055;UBPY P40818 ENST00000307179;ENST00000396444 K11839 1 1.2546 1.9954 1.2957 1.6128 1.3367 1.6585 MAPKK1_Int cell part;cytoplasmic part;endosomal part;endosome membrane;intracellular organelle part;intracellular part;late endosome membrane;membrane;organelle membrane;organelle part binding;protein binding MAPK signaling pathway 2 2 2 26.6 26.6 26.6 13.623 0.0036269 31147000 16607000 14540000 2267 IPI:IPI00030919.3 Mitogen-activated protein kinase scaffold protein 1;Mitogen-activated protein kinase kinase 1-interacting protein 1;MEK-binding partner 1 MAPKSP1;MAP2K1IP1;PRO2783 Q9UHA4 ENST00000226522 K04370 1 0.85377 1.6299 0.73397 1.0375 1.0453 0.94512 3 3 3 17.6 17.6 17.6 21.639 3.8124E-51 54618000 29197000 25422000 2268 IPI:IPI00030968.4 Uncharacterized protein C9orf142 C9orf142 Q9BUH6-1;Q9BUH6 ENST00000371620 1 0.85184 1.3762 1.3861 1.0758 0.95815 1.7154 DUF59 3 3 3 21.2 21.2 21.2 18.355 2.4539E-48 40193000 15450000 24743000 2269 IPI:IPI00030985.1 UPF0195 protein FAM96A FAM96A Q9H5X1 ENST00000300030 1 0.90695 1.4571 NaN 1.1988 0.91653 NaN Pkinase_Tyr cell part;integral to membrane;intrinsic to membrane;membrane part ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein tyrosine kinase activity;purine nucleoside binding;transferase activity cellular biopolymer metabolic process;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process 2 2 2 6.6 6.6 6.6 40.05 7.1676E-05 8784100 4243700 4540300 2271 IPI:IPI00031005.3 Protein kinase-like protein SgK196;Sugen kinase 196 SGK196 Q9H5K3 ENST00000331373 1 0.16262 NaN 0.11113 0.2255 NaN 0.16396 cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;ribonucleoprotein complex binding;mRNA binding;nucleic acid binding;RNA binding cellular process;histone mRNA 3'-end processing;histone mRNA metabolic process;metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing 4 4 4 14.1 14.1 14.1 31.285 6.5534E-13 32105000 19607000 12498000 2272 IPI:IPI00031015.1 Histone RNA hairpin-binding protein;Histone stem-loop-binding protein SLBP;HBP Q14493 ENST00000318386 1 0.55643 1.1569 0.56541 0.7155 0.76835 0.72568 Gelsolin;LRR_1 centrosome;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;microtubule organizing center;non-membrane-bounded organelle;nucleus;organelle;organelle part actin binding;binding;cytoskeletal protein binding;protein binding multicellular organismal development;muscle contraction;muscle system process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;system process;transcription 22 22 22 21.3 21.3 21.3 144.75 8.0504E-242 494540000 310900000 183640000 2273 IPI:IPI00031023.1 Protein flightless-1 homolog FLII;FLIL Q13045 ENST00000327031 1 0.60476 NaN 0.64543 0.91623 NaN 0.8701 A4_EXTRA;APP_amyloid;Kunitz_BPTI cell part;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane;membrane part;membrane-bounded organelle;nucleus;organelle;plasma membrane binding;DNA binding;endopeptidase inhibitor activity;enzyme inhibitor activity;enzyme regulator activity;identical protein binding;nucleic acid binding;peptidase inhibitor activity;protein binding;serine-type endopeptidase inhibitor activity biological regulation;cell communication;cell surface receptor linked signal transduction;cellular process;G-protein coupled receptor protein signaling pathway;regulation of biological process;regulation of cellular process;signal transduction 3 3 3 5.2 5.2 5.2 86.955 5.77E-17 5994500 3392300 2602200 2274 IPI:IPI00031030.1;IPI:IPI00220978.3;IPI:IPI00220977.1;IPI:IPI00884988.1;IPI:IPI00334946.4 Amyloid-like protein 2;Amyloid protein homolog;APPH;CDEI box-binding protein APLP2;APPL2 Q06481-1;Q06481;Q06481-3;Q06481-2;Q06481-4;Q06481-5 ENST00000263574;ENST00000278756;ENST00000338167;ENST00000345598 K08117 5 0.64445 1.9865 0.84883 0.86444 1.2856 1.077 DUF1370 cell part;cytoplasmic part;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane part;membrane-bounded organelle;mitochondrion;organelle 7 7 7 33.3 33.3 33.3 21.527 9.4836E-10 69603000 40697000 28907000 2275 IPI:IPI00031064.1 Transmembrane protein 126A TMEM126A Q9H061 ENST00000304511 1 NaN 0.65451 NaN NaN 0.45269 NaN Cyclin_N cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 4 4 4 14.1 14.1 14.1 33.242 9.7395E-12 551250 263040 288210 2276 IPI:IPI00031076.4 Cyclin-C;SRB11 homolog CCNC P24863 ENST00000326298;ENST00000369220 1 0.69674 1.8579 1.0363 0.90507 1.2436 1.3571 efhand binding;calcium ion binding;cation binding;ion binding;metal ion binding;protein binding 4 2 2 17.6 8.8 8.8 26.927 3.8094E-15 21322000 10558000 10764000 2277 IPI:IPI00031091.3 EF-hand domain-containing protein D1;EF-hand domain-containing protein 1;Swiprosin-2 EFHD1;SWS2;PP3051 Q9BUP0 ENST00000264059 1 0.69243 1.5739 0.7939 0.90906 1.0256 1.0537 DUF2372 4 4 4 42.6 42.6 42.6 13.104 1.2678E-65 127840000 68277000 59559000 2279 IPI:IPI00031106.1 Proteasome assembly chaperone 3 PSMG3;C7orf48;PAC3 Q9BT73 ENST00000252329;ENST00000288607;ENST00000404674 K11877 1 0.69291 1.6131 0.6554 0.97052 0.95933 0.92131 adh_short;SCP2 binding;catalytic activity;lipid binding;oxidoreductase activity;steroid binding;sterol binding;sterol carrier activity metabolic process;oxidation reduction 5 5 5 17.9 17.9 17.9 45.394 5.8208E-143 159260000 88194000 71066000 2280 IPI:IPI00414384.1;IPI:IPI00031107.1 Hydroxysteroid dehydrogenase-like protein 2 HSDL2 Q6YN16-1;Q6YN16;Q6YN16-2 ENST00000398805 2 0.68479 1.2602 0.63957 0.96982 0.80386 0.83778 NDUFA12 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;mitochondrion;organelle catalytic activity;electron carrier activity;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH 6 6 6 45.6 45.6 45.6 19.856 2.652E-33 106740000 57913000 48822000 2281 IPI:IPI00031109.4 Mimitin, mitochondrial;Myc-induced mitochondrial protein;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2;B17.2-like;NDUFA12-like protein NDUFAF2;NDUFA12L Q8N183 ENST00000296597 1 0.93714 1.933 1.0237 1.2593 1.2241 1.3784 Yip1 cell part;cytoplasmic part;endoplasmic reticulum;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane part;membrane-bounded organelle;organelle 2 2 2 9 9 9 27.082 7.3036E-07 10404000 5369800 5033900 2283 IPI:IPI00031127.1 Protein YIPF4;YIP1 family member 4 YIPF4;Nbla11189 Q9BSR8 ENST00000238831 1 0.81956 1.9349 0.85094 1.1241 1.2368 1.1551 Str_synth cell part;cell surface;integral to membrane;intrinsic to membrane;membrane part amine-lyase activity;arylesterase activity;carbon-nitrogen lyase activity;carboxylesterase activity;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;lyase activity;strictosidine synthase activity biosynthetic process;metabolic process 14 14 13 34.9 34.9 33.2 46.48 1.8037E-84 814080000 420270000 393800000 2284 IPI:IPI00031131.4;IPI:IPI00929530.1 Adipocyte plasma membrane-associated protein;Protein BSCv APMAP;C20orf3;UNQ1869/PRO4305 Q9HDC9-1;Q9HDC9;Q9HDC9-2 ENST00000217456 2 0.63188 1.3491 NaN 0.77825 0.96125 NaN Mito_carr cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part binding;transporter activity establishment of localization;response to chemical stimulus;response to endogenous stimulus;response to estradiol stimulus;response to estrogen stimulus;response to hormone stimulus;response to organic substance;transport 2 2 2 8.4 8.4 8.4 35.375 2.1714E-15 2549500 1502900 1046600 2285 IPI:IPI00031133.1;IPI:IPI00301303.4;IPI:IPI00848033.1;IPI:IPI00795271.2 Solute carrier family 25 member 33;Bone marrow stromal cell mitochondrial carrier protein;HuBMSC-MCP;Protein PNC1;Solute carrier family 25 member 36 SLC25A33;SLC25A36 Q9BSK2;Q96CQ1-1;Q96CQ1;Q96CQ1-3;Q96CQ1-2 ENST00000302692;ENST00000324194;ENST00000393015 4 0.85493 1.7571 0.89036 1.1518 1.1581 1.1622 Ras cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;endoplasmic reticulum membrane;ER-Golgi intermediate compartment membrane;Golgi membrane;melanosome;membrane;membrane-bounded organelle;membrane-bounded vesicle;organelle;organelle membrane;vesicle binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleotide binding;pyrophosphatase activity cell communication;cellular process;ER to Golgi vesicle-mediated transport;intracellular signaling cascade;protein transport;signal transduction;small GTPase mediated signal transduction;transport;vesicle-mediated transport 12 5 5 59.9 31.1 31.1 23.545 2.8295E-255 318900000 168670000 150230000 2287 IPI:IPI00031169.1 Ras-related protein Rab-2A RAB2A;RAB2 P61019 ENST00000262646;ENST00000396697 K07877 1 NaN 1.6485 NaN NaN 1.1591 NaN Strabismus cell part;integral to membrane;intrinsic to membrane;membrane part binding;protein binding developmental process;multicellular organismal development;multicellular organismal process Wnt signaling pathway 2 2 2 4.4 4.4 4.4 59.974 5.6288E-63 514480 87510 426970 2288 IPI:IPI00031195.5;IPI:IPI00386349.1 Vang-like protein 1;Van Gogh-like protein 1;Strabismus 2;Loop-tail protein 2 homolog VANGL1;STB2 Q8TAA9-1;Q8TAA9;Q8TAA9-2 ENST00000310260;ENST00000355485;ENST00000369509 K04510 2 0.68974 1.3411 0.745 0.91255 0.86505 0.99124 AMP-binding cell fraction;endoplasmic reticulum membrane;insoluble fraction;integral to membrane;intrinsic to membrane;membrane;membrane fraction;microbody membrane;microsome;mitochondrial outer membrane;organelle membrane;outer membrane;peroxisomal membrane acyltransferase activity;ATP binding;binding;catalytic activity;fatty-acyl-CoA synthase activity;long-chain-fatty-acid-CoA ligase activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding carboxylic acid metabolic process;cellular ketone metabolic process;cellular process;fatty acid metabolic process;lipid metabolic process;metabolic process;monocarboxylic acid metabolic process;organic acid metabolic process;oxoacid metabolic process Adipocytokine signaling pathway;Fatty acid metabolism;PPAR signaling pathway 22 22 19 35.8 35.8 31 80.419 0 698910000 383440000 315470000 2290 IPI:IPI00031397.3 Long-chain-fatty-acid--CoA ligase 3;Long-chain acyl-CoA synthetase 3 ACSL3;ACS3;FACL3;LACS3 O95573 ENST00000357430;ENST00000392066 K01897 1 0.61795 1.1812 0.59088 0.83329 0.7616 0.76375 FAT;FATC;PI3_PI4_kinase;Rapamycin_bind cell part;cytoplasmic part;cytosolic part;intracellular part;macromolecular complex;membrane;phosphoinositide 3-kinase complex;protein complex;TORC1 complex;TORC2 complex binding;catalytic activity;kinase activity;protein binding;protein kinase activity;protein serine/threonine kinase activity;transferase activity;transferase activity, transferring phosphorus-containing groups catabolic process;cell communication;macromolecule catabolic process;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;response to nutrient;signal transduction Acute myeloid leukemia;Adipocytokine signaling pathway;ErbB signaling pathway;Glioma;Insulin signaling pathway;mTOR signaling pathway;Pathways in cancer;Prostate cancer;Type II diabetes mellitus 16 16 16 8.1 8.1 8.1 288.89 8.1057E-182 84948000 47411000 37538000 2291 IPI:IPI00031410.1 Serine/threonine-protein kinase mTOR;Mammalian target of rapamycin;FKBP12-rapamycin complex-associated protein;FK506-binding protein 12-rapamycin complex-associated protein 1;Rapamycin target protein;RAPT1 FRAP1;FRAP;FRAP2 P42345 ENST00000361445 K07203 1 0.94932 2.1059 0.96468 1.2614 1.3832 1.2391 UDPG_MGDP_dh;UDPG_MGDP_dh_C;UDPG_MGDP_dh_N binding;catalytic activity;electron carrier activity;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;UDP-glucose 6-dehydrogenase activity aminoglycan biosynthetic process;aminoglycan metabolic process;carbohydrate metabolic process;glucose metabolic process;monosaccharide metabolic process;polysaccharide biosynthetic process;polysaccharide metabolic process;UDP-glucose metabolic process Ascorbate and aldarate metabolism;Nucleotide sugars metabolism;Pentose and glucuronate interconversions;Starch and sucrose metabolism 6 6 6 15.6 15.6 15.6 55.023 2.0907E-55 36525000 12019000 24507000 2292 IPI:IPI00031420.3 UDP-glucose 6-dehydrogenase UGDH O60701 ENST00000316423 K00012 1 0.88476 1.5054 0.67344 1.1735 0.95982 0.96886 Thioredoxin endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;membrane-enclosed lumen;organelle;organelle lumen;organelle part catalytic activity;intramolecular oxidoreductase activity;intramolecular oxidoreductase activity, interconverting keto- and enol-groups;isomerase activity;oxidoreductase activity;protein disulfide isomerase activity biopolymer metabolic process;cellular biopolymer metabolic process;cellular homeostasis;cellular process;homeostatic process;macromolecule metabolic process;metabolic process;protein folding;protein metabolic process;response to stress 6 6 6 12.7 12.7 12.7 59.594 1.2342E-16 92449000 49180000 43269000 2294 IPI:IPI00031479.1 Protein disulfide-isomerase A5;Protein disulfide isomerase-related protein PDIA5;PDIR Q14554 ENST00000316218 K09583 1 0.67173 1.3095 0.73516 0.89033 0.85749 0.94874 3 3 3 21.6 21.6 21.6 12.266 4.4931E-24 99833000 55211000 44622000 2295 IPI:IPI00031485.1 Ribosomal protein 63, mitochondrial;hMRP63 MRP63 Q9BQC6 ENST00000309594 1 0.89516 1.7002 0.9288 1.243 1.0874 1.2559 DUF1605;HA2;Helicase_C;S1 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex ATP binding;ATP-dependent helicase activity;ATP-dependent RNA helicase activity;binding;catalytic activity;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;RNA binding;RNA helicase activity cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 13 12 12 14.8 14.1 14.1 139.31 1.4367E-91 74999000 37744000 37255000 2296 IPI:IPI00031508.1 ATP-dependent RNA helicase DHX8;DEAH box protein 8;RNA helicase HRH1 DHX8;DDX8 Q14562 ENST00000262415 1 0.66199 1.1619 0.5931 0.83796 0.78543 0.82131 AAA;Rep_fac_C cell part;chromosomal part;DNA replication factor C complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;protein complex ATP binding;binding;catalytic activity;DNA binding;DNA clamp loader activity;DNA-dependent ATPase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity biosynthetic process;DNA metabolic process;DNA replication;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleotide-excision repair, DNA gap filling DNA replication;Mismatch repair;Nucleotide excision repair 11 11 11 40.3 40.3 40.3 38.496 7.6793E-147 260810000 142820000 117990000 2297 IPI:IPI00031514.1 Replication factor C subunit 5;Activator 1 subunit 5;Replication factor C 36 kDa subunit;Activator 1 36 kDa subunit RFC5 P40937 ENST00000229043 K10756 1 0.69641 1.2463 0.70515 0.91078 0.84292 0.90314 MCM cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cell cycle;DNA metabolic process;DNA replication initiation;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription Cell cycle;Cell cycle - yeast;DNA replication 38 38 38 44.7 44.7 44.7 92.888 0 5499200000 2899600000 2599600000 2298 IPI:IPI00031517.1 DNA replication licensing factor MCM6;p105MCM MCM6 Q14566 ENST00000264156 K02542 1 0.62144 1.1778 0.68866 0.81405 0.82736 0.8805 RFC-E_C cell part;chromosomal part;DNA replication factor C complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;protein complex binding;catalytic activity;DNA binding;DNA clamp loader activity;DNA-dependent ATPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleic acid binding;nucleotide binding;protein binding;pyrophosphatase activity DNA metabolic process;DNA replication;DNA strand elongation during DNA replication;DNA synthesis during DNA repair;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleotide-excision repair, DNA gap filling DNA replication;Mismatch repair;Nucleotide excision repair 17 17 17 44.4 44.4 44.4 40.556 1.5637E-243 375480000 199670000 175810000 2299 IPI:IPI00031521.1 Replication factor C subunit 3;Activator 1 subunit 3;Replication factor C 38 kDa subunit;Activator 1 38 kDa subunit RFC3 P40938 ENST00000380071 K10756 1 0.86653 1.5387 0.79436 1.142 1.0026 1.0533 3HCDH;3HCDH_N;ECH cell part;cytoplasmic part;fatty acid beta-oxidation multienzyme complex;intracellular organelle part;intracellular part;macromolecular complex;mitochondrial nucleoid;mitochondrial part;nucleoid;organelle part;protein complex 3-hydroxyacyl-CoA dehydrogenase activity;acetyl-CoA C-acetyltransferase activity;acetyltransferase activity;acyltransferase activity;C-acetyltransferase activity;C-acyltransferase activity;catalytic activity;enoyl-CoA hydratase activity metabolic process;oxidation reduction Benzoate degradation via CoA ligation;beta-Alanine metabolism;Biosynthesis of unsaturated fatty acids;Butanoate metabolism;Caprolactam degradation;Fatty acid elongation in mitochondria;Fatty acid metabolism;Limonene and pinene degradation;Lysine degradation;Propanoate metabolism;Tryptophan metabolism;Valine, leucine and isoleucine degradation 29 29 29 50.1 50.1 50.1 82.999 0 1481100000 771010000 710070000 2300 IPI:IPI00031522.2 Trifunctional enzyme subunit alpha, mitochondrial;TP-alpha;78 kDa gastrin-binding protein;Long-chain enoyl-CoA hydratase;Long chain 3-hydroxyacyl-CoA dehydrogenase HADHA;HADH P40939 ENST00000380649 K07510;K07515 1 0.61529 1.545 0.60023 0.90713 0.90794 0.9839 6 6 6 31.8 31.8 31.8 18.419 2.8027E-31 308240000 160790000 147450000 2301 IPI:IPI00031526.3 Uncharacterized protein C19orf43 C19orf43 Q9BQ61 ENST00000242784 1 NaN 1.1977 NaN NaN 0.72175 NaN Mis12 chromosomal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;macromolecular complex;membrane-bounded organelle;MIS12/MIND type complex;nucleus;organelle;organelle part;protein complex binding;protein binding anatomical structure formation;cell cycle phase;cell cycle process;cellular component assembly;cellular component organization;cellular process;chromosome segregation;mitosis;nuclear division;organelle organization;protein complex assembly 2 2 2 15.6 15.6 15.6 24.14 6.9825E-10 1464000 834980 629060 2302 IPI:IPI00031527.1 Protein MIS12 homolog MIS12 Q9H081 ENST00000381165;ENST00000406705 K11543 1 0.61707 1.3659 0.45545 0.81092 0.98012 0.60295 Ins145_P3_rec;Ion_trans;MIR;RIH_assoc;RYDR_ITPR cell fraction;endoplasmic reticulum membrane;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part;plasma membrane enriched fraction;sarcoplasmic reticulum membrane calcium channel activity;cation channel activity;inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity;intracellular ligand-gated ion channel activity;ion channel activity;receptor activity;signal transducer activity;transporter activity calcium ion transport;cation transport;cell communication;cellular process;di-, tri-valent inorganic cation transport;ion transport;metal ion transport;response to chemical stimulus;response to hypoxia;response to stress;signal transduction;transport Alzheimer's disease;Calcium signaling pathway;Gap junction;GnRH signaling pathway;Long-term depression;Long-term potentiation;Phosphatidylinositol signaling system;Vascular smooth muscle contraction 5 5 3 2.2 2.2 1.3 308.06 4.9278E-32 8222000 4838300 3383700 2303 IPI:IPI00031545.4;IPI:IPI00218668.1 Inositol 1,4,5-trisphosphate receptor type 2;Type 2 inositol 1,4,5-trisphosphate receptor;Type 2 InsP3 receptor;IP3 receptor isoform 2;InsP3R2 ITPR2 Q14571-1;Q14571 ENST00000242737;ENST00000381340 K04959 2 NaN NaN 0.76658 NaN NaN 1.1241 Cadherin;Cadherin_pro anchoring junction;cell fraction;cell junction;cell part;cell-cell junction;desmosome;insoluble fraction;integral to membrane;intrinsic to membrane;membrane fraction;membrane part;plasma membrane part binding;calcium ion binding;cation binding;ion binding;metal ion binding;protein binding biological adhesion;cell adhesion;cell-cell adhesion;cellular process;homophilic cell adhesion 3 3 3 3.8 3.8 3.8 99.968 3.9131E-18 1078900 614140 464790 2304 IPI:IPI00031549.5;IPI:IPI00218928.2 Desmocollin-3;Desmocollin-4;HT-CP DSC3;CDHF3;DSC4 Q14574-1;Q14574;Q14574-2 ENST00000360428;ENST00000389543 K07602 2 0.75487 1.3364 0.80668 1.0112 0.86163 1.0507 DEAD;GUCT;Helicase_C cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part ATP binding;ATP-dependent helicase activity;binding;catalytic activity;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity;RNA binding Folate biosynthesis 21 19 19 34.7 33.1 33.1 82.564 3.7325E-171 398730000 208270000 190460000 2305 IPI:IPI00031554.1 ATP-dependent RNA helicase DDX50;DEAD box protein 50;Nucleolar protein Gu2;Gu-beta DDX50 Q9BQ39 ENST00000373585 K01529 1 0.80732 1.6749 0.7934 1.0755 1.1035 1.0461 RRM_1 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 11 11 11 38.5 38.5 38.5 53.5 0 1384000000 739490000 644530000 2306 IPI:IPI00031556.7;IPI:IPI00830039.1 Splicing factor U2AF 65 kDa subunit;U2 auxiliary factor 65 kDa subunit;U2 snRNP auxiliary factor large subunit U2AF2;U2AF65 P26368-1;P26368;P26368-2 ENST00000308924 2 0.64198 1.5205 0.64888 0.86272 0.99066 0.87178 Cys_Met_Meta_PP cell part;cytoplasm;intracellular part binding;carbon-sulfur lyase activity;catalytic activity;cofactor binding;cystathionine gamma-lyase activity;lipid binding;lyase activity;pyridoxal phosphate binding;steroid binding;vitamin B6 binding;vitamin binding cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;cysteine metabolic process;organic acid metabolic process;sulfur amino acid biosynthetic process;sulfur amino acid metabolic process;sulfur metabolic process Cysteine metabolism;Glycine, serine and threonine metabolism;Methionine metabolism;Nitrogen metabolism;Selenoamino acid metabolism 7 7 7 21.7 21.7 21.7 44.508 3.8382E-131 105870000 57528000 48343000 2307 IPI:IPI00031557.2;IPI:IPI00221301.1 Cystathionine gamma-lyase;Gamma-cystathionase CTH P32929-1;P32929;P32929-2 ENST00000346806;ENST00000370938 K01758 2 1.7896 3.2944 1.8925 2.2641 2.1839 2.2744 NUDIX cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle binding;calcium activated cation channel activity;catalytic activity;cation channel activity;cation transmembrane transporter activity;channel activity;ion channel activity;ion transmembrane transporter activity;magnesium ion binding;transporter activity cation transport;establishment of localization;ion transport;transport Purine metabolism 5 5 5 16.9 16.9 16.9 39.125 3.8662E-19 55952000 24902000 31050000 2308 IPI:IPI00031558.3;IPI:IPI00415040.1 ADP-ribose pyrophosphatase, mitochondrial;ADP-ribose diphosphatase;Adenosine diphosphoribose pyrophosphatase;ADP-ribose phosphohydrolase;Nucleoside diphosphate-linked moiety X motif 9 NUDT9;NUDT10;PSEC0099;UNQ3012/PRO9771 Q9BW91-1;Q9BW91;Q9BW91-2 ENST00000302174;ENST00000358033 K01515 2 0.60987 1.4906 0.57905 0.77219 1.0247 0.75256 AIG2 cell part;cytoplasmic part;cytosol;intracellular part acyltransferase activity;binding;catalytic activity;gamma-glutamylcyclotransferase activity;protein binding;transferase activity;transferase activity, transferring acyl groups;transferase activity, transferring acyl groups other than amino-acyl groups apoptotic mitochondrial changes;cellular component organization;cellular process;mitochondrion organization;organelle organization;release of cytochrome c from mitochondria Glutathione metabolism 7 7 7 45.7 45.7 45.7 21.007 6.1196E-64 187510000 106360000 81146000 2310 IPI:IPI00031564.1;IPI:IPI00020301.1 Gamma-glutamylcyclotransferase;Cytochrome c-releasing factor 21 GGCT;C7orf24;CRF21 O75223-1;O75223 ENST00000275428 K00682 2 0.85664 1.5295 0.79292 1.0757 1.0196 1.0732 DUF265 ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity;transferase activity 8 8 8 58.9 58.9 58.9 20.713 5.429E-246 366570000 190330000 176240000 2311 IPI:IPI00031570.1 Nucleoside-triphosphatase C1orf57;Nucleoside triphosphate phosphohydrolase C1orf57 Q9BSD7 ENST00000366627;ENST00000366628 1 0.70178 1.5975 0.61834 0.89071 1.061 0.82105 AAA cell part;cytoplasm;intracellular part ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity 6 6 6 11.4 11.4 11.4 80.681 9.5255E-147 132390000 70599000 61789000 2312 IPI:IPI00031608.3;IPI:IPI00890778.1;IPI:IPI00386906.2 Spermatogenesis-associated protein 5-like protein 1 SPATA5L1 Q9BVQ7-1;Q9BVQ7;Q9BVQ7-2 ENST00000305560;ENST00000396655 3 0.77167 1.2146 0.6212 0.98665 0.86609 0.83165 Fcf1 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 3 3 3 18.5 18.5 18.5 28.43 5.0271E-32 19719000 10789000 8930000 2313 IPI:IPI00031612.3;IPI:IPI00163111.5 rRNA-processing protein UTP23 homolog UTP23;C8orf53 Q9BRU9-1;Q9BRU9;Q9BRU9-2 ENST00000309822;ENST00000357148 2 0.58593 1.1818 0.59874 0.81774 0.74994 0.80012 Sld5 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle biosynthetic process;cellular process;DNA metabolic process;DNA replication;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 7 7 7 36.3 36.3 36.3 26.047 7.099E-21 100270000 51428000 48844000 2314 IPI:IPI00031614.2;IPI:IPI00792990.1 DNA replication complex GINS protein SLD5;GINS complex subunit 4 GINS4;SLD5 Q9BRT9-1;Q9BRT9 ENST00000276533 K10735 2 0.78336 1.7713 0.99322 0.96826 0.90773 1.221 Laps 3 3 3 29.5 29.5 29.5 15.225 1.0984E-23 46281000 19666000 26616000 2315 IPI:IPI00031615.3 Protein LLP homolog;Protein LAPS18-like LLPH;C12orf31 Q9BRT6 ENST00000266604 1 0.66828 1.4032 0.84763 0.83766 0.98146 1.0396 2 2 2 15.9 15.9 15.9 14.875 5.0117E-05 18334000 8688400 9645200 2316 IPI:IPI00031617.3 Uncharacterized protein C6orf125;Breast cancer-associated protein SGA-81M C6orf125 Q9BRT2 ENST00000374231 1 0.79245 1.4321 0.73858 1.0193 0.96863 0.95692 Asp_protease;ubiquitin aspartic-type endopeptidase activity;aspartic-type peptidase activity;catalytic activity;endopeptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis 7 7 7 22.9 22.9 22.9 46.571 8.3589E-94 307320000 159330000 147990000 2317 IPI:IPI00031618.3;IPI:IPI00845258.1;IPI:IPI00796836.2 Protein DDI1 homolog 2 DDI2 Q5TDH0-3;Q5TDH0;Q5TDH0-1;Q5TDH0-2 ENST00000320153;ENST00000406234 K11885 3 0.84713 1.8903 0.85263 1.0793 1.2842 1.1398 ICAM_N;ig cell part;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part binding;integrin binding;protein binding;protein complex binding;receptor binding biological adhesion;cell adhesion;cell-cell adhesion;cellular process Cell adhesion molecules (CAMs) 4 4 4 6.4 6.4 6.4 59.54 1.9431E-06 49474000 27270000 22204000 2318 IPI:IPI00031620.2 Intercellular adhesion molecule 3;ICAM-R;CDw50 ICAM3 P32942 ENST00000160262 K06486 1 1.3194 2.452 1.3325 1.8205 1.504 1.7754 CHCH;DUF737 4 4 4 26 26 26 26.457 1.555E-40 109470000 50835000 58631000 2319 IPI:IPI00031622.3 Coiled-coil-helix-coiled-coil-helix domain-containing protein 6 CHCHD6 Q9BRQ6 ENST00000290913;ENST00000393418 1 0.62688 1.0971 0.60402 0.81157 0.71439 0.78623 RNA_pol_Rpb1_1;RNA_pol_Rpb1_2;RNA_pol_Rpb1_3;RNA_pol_Rpb1_4;RNA_pol_Rpb1_5;RNA_pol_Rpb1_6;RNA_pol_Rpb1_7;RNA_pol_Rpb1_R cell part;DNA-directed RNA polymerase complex;DNA-directed RNA polymerase II, core complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;RNA polymerase complex binding;catalytic activity;DNA binding;DNA-directed RNA polymerase activity;magnesium ion binding;nucleic acid binding;protein binding;RNA-directed RNA polymerase activity;transferase activity;zinc ion binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile Huntington's disease;RNA polymerase 42 42 42 25 25 25 217.17 0 709090000 382820000 326270000 2320 IPI:IPI00031627.4 DNA-directed RNA polymerase II subunit RPB1;DNA-directed RNA polymerase II subunit A;DNA-directed RNA polymerase III largest subunit;RNA-directed RNA polymerase II subunit RPB1 POLR2A P24928 ENST00000322644 K03006 1 0.76128 1.6083 NaN 1.1274 1.1352 NaN Phosducin cell part;cytoplasm;intracellular part binding;protein binding apoptosis;cell death;cellular process;death;interspecies interaction between organisms;multi-organism process;programmed cell death 4 4 4 28.9 28.9 28.9 27.614 8.9204E-23 24146000 13309000 10837000 2321 IPI:IPI00031629.1 Phosducin-like protein 3;PhPL3;Viral IAP-associated factor 1;HTPHLP PDCL3;VIAF1 Q9H2J4 ENST00000264254;ENST00000393429 1 NaN 1.2517 NaN NaN 0.81215 NaN 2 2 2 4.9 4.9 4.9 50.046 2.7069E-07 5487400 2809500 2677900 2322 IPI:IPI00043294.1;IPI:IPI00031632.1 Uncharacterized protein C7orf26 C7orf26 Q96N11-1;Q96N11;Q96N11-2 ENST00000344417;ENST00000359073 2 0.33078 0.81069 0.31566 0.43748 0.5304 0.38954 PDCD2_C cell part;cytoplasm;intracellular part 2 2 2 7.5 7.5 7.5 39.416 1.2191E-28 15064000 9414900 5648900 2324 IPI:IPI00031647.2 Programmed cell death protein 2-like PDCD2L Q9BRP1 ENST00000246535 1 0.62875 1.2661 0.57815 0.80574 0.85609 0.76335 cell part;cytoplasm;intracellular part 7 7 7 43.6 43.6 43.6 23.338 2.2383E-119 110300000 63184000 47115000 2325 IPI:IPI00031650.3;IPI:IPI00168009.1;IPI:IPI00783497.2 Protein syndesmos;NUDT16-like protein 1 NUDT16L1;SDOS Q9BRJ7-1;Q9BRJ7 ENST00000304301;ENST00000405142 3 0.58237 1.5947 0.715 0.73137 1.1258 0.89815 DUF2373 3 3 3 18 18 18 22.083 7.1409E-07 52254000 27918000 24336000 2326 IPI:IPI00031651.1 Uncharacterized protein C7orf50 C7orf50;FP15621 Q9BRJ6 ENST00000357429;ENST00000397098;ENST00000397100 1 0.89656 1.5266 0.42376 1.1098 1.0763 0.52529 ESCRT-II cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription;transport 6 6 6 30.7 30.7 30.7 20.747 4.886E-24 49204000 24388000 24816000 2327 IPI:IPI00031655.1 Vacuolar protein-sorting-associated protein 25;ESCRT-II complex subunit VPS25;ELL-associated protein of 20 kDa;Dermal papilla-derived protein 9 VPS25;DERP9;EAP20 Q9BRG1 ENST00000253794 K12189 1 0.55868 1.0929 0.53461 0.72365 0.71263 0.72606 CBF integral to membrane;intracellular organelle;intrinsic to membrane;macromolecular complex;membrane;non-membrane-bounded organelle;nuclear membrane;nucleolus;organelle;organelle membrane;ribonucleoprotein complex;small nucleolar ribonucleoprotein complex binding;protein binding 17 17 17 39.9 39.9 39.9 58.467 6.7042E-131 538140000 289810000 248330000 2328 IPI:IPI00031661.1 Nucleolar complex protein 4 homolog;NOC4-like protein;Nucleolar complex-associated protein 4-like protein NOC4L Q9BVI4 ENST00000330579 1 NaN 1.2982 NaN NaN 0.90862 NaN UPF0061 binding;selenium binding 5 5 5 9.1 9.1 9.1 73.442 3.068E-30 4824300 2251900 2572400 2329 IPI:IPI00031666.6 Selenoprotein O SELO Q9BVL4 ENST00000380903 1 0.45219 0.67358 NaN 0.57375 0.47966 NaN 2 2 2 2.7 2.7 2.7 57.485 9.2377E-24 1369900 700020 669840 2331 IPI:IPI00031678.2 Coiled-coil domain-containing protein 77 CCDC77 Q9BR77 ENST00000239830 1 0.5812 1.1754 0.63482 0.78861 0.77942 0.82806 10 10 10 34.8 34.8 34.8 31.884 9.9779E-40 371770000 212890000 158880000 2332 IPI:IPI00031679.2 Uncharacterized protein C3orf26 C3orf26 Q9BQ75 ENST00000333147 1 0.78025 1.2105 0.72916 0.95996 0.78467 0.89193 ACBP;Ank cell part;cytoplasm;intracellular part acyl-CoA binding;binding;carboxylic acid binding;coenzyme binding;cofactor binding;fatty acid binding;lipid binding;monocarboxylic acid binding 4 4 4 16 16 16 31.15 1.0335E-12 19745000 10458000 9287400 2333 IPI:IPI00031680.3 Acyl-CoA-binding domain-containing protein 6 ACBD6 Q9BR61 ENST00000367595 1 0.70384 1.3322 0.68288 0.96445 0.86972 0.91933 Pkinase cell part;cyclin-dependent protein kinase holoenzyme complex;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;protein complex ATP binding;binding;catalytic activity;cyclin-dependent protein kinase activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding DNA metabolic process;DNA replication;G2/M transition of mitotic cell cycle;nuclear division;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein modification process;regulation of DNA replication Cell cycle;p53 signaling pathway;Pathways in cancer;Progesterone-mediated oocyte maturation;Prostate cancer;Small cell lung cancer 20 18 16 60.4 54 50 33.929 1.7893E-195 236100000 126890000 109200000 2334 IPI:IPI00031681.1 Cell division protein kinase 2;p33 protein kinase CDK2 P24941 ENST00000266970 K02206 1 0.72834 1.4574 0.6737 0.95751 0.96133 0.87182 Ribosomal_L6 cytoplasmic part;cytosol;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;ribonucleoprotein complex;ribosome binding;nucleic acid binding;RNA binding;rRNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 12 12 12 62 62 62 21.863 6.8597E-150 13947000000 10950000000 2997400000 2335 IPI:IPI00031691.1;IPI:REV_IPI00026555.1;IPI:REV_IPI00514782.1;IPI:REV_IPI00909385.1 60S ribosomal protein L9 RPL9;OK/SW-cl.103;RPL9P7;RPL9P8;RPL9P9 P32969 ENST00000295955;ENST00000330965 K02940 4 1.299 1.0503 0.82065 1.6914 0.72963 1.0969 DUF1669;FAST_1;FAST_2;RAP ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups apoptosis;cell death;cellular process;death;programmed cell death + 2 2 2 2.4 2.4 2.4 75.716 0.0065449 7239800 3702000 3537800 2336 IPI:IPI00031696.4;IPI:REV_IPI00304527.4 FAST kinase domain-containing protein 3;Protein FAM83B FASTKD3;FAM83B;C6orf143 Q14CZ7;Q5T0W9 ENST00000264669;ENST00000306858 2 0.94959 1.7788 0.65708 1.2004 1.083 0.83492 4 4 4 37.1 37.1 37.1 25.858 2.7959E-16 36242000 14938000 21305000 2338 IPI:IPI00031698.4 Ashwin C2orf49 Q9BVC5 ENST00000258457 1 0.7738 1.5226 0.73651 0.96738 1.0248 0.99141 DUF1969;FAA_hydrolase cell part;cytoplasmic part;cytosol;intracellular part binding;calcium ion binding;catalytic activity;fumarylacetoacetase activity;hydrolase activity;hydrolase activity, acting on acid carbon-carbon bonds;hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances;magnesium ion binding cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;L-phenylalanine catabolic process;L-phenylalanine metabolic process;organic acid metabolic process;tyrosine catabolic process;tyrosine metabolic process Styrene degradation;Tyrosine metabolism 9 9 9 26.7 26.7 26.7 46.374 3.8417E-227 297810000 159500000 138320000 2339 IPI:IPI00031708.1 Fumarylacetoacetase;Fumarylacetoacetate hydrolase;Beta-diketonase FAH P16930 ENST00000261755;ENST00000407106 K01555 1 0.85489 1.6447 0.59671 1.0865 1.1125 0.78017 Abi cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;integral to plasma membrane;intracellular part;intrinsic to membrane;intrinsic to plasma membrane;membrane;membrane part;organelle membrane;organelle part catalytic activity;endopeptidase activity;hydrolase activity;metalloendopeptidase activity;metallopeptidase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis 2 2 2 8.2 8.2 8.2 35.832 7.1826E-30 11045000 5803600 5241000 2341 IPI:IPI00031755.1 CAAX prenyl protease 2;Prenyl protein-specific endoprotease 2;Farnesylated proteins-converting enzyme 2;RCE1 homolog RCE1;FACE2;RCE1A;RCE1B Q9Y256 ENST00000309657 K08658 1 0.88721 1.6929 NaN 1.1317 1.0625 NaN HOOK cell part;cis-Golgi network;cytoplasmic part;cytoskeletal part;Golgi apparatus part;intracellular organelle part;intracellular part;microtubule;organelle part binding;cytoskeletal protein binding;microtubule binding;protein binding;tubulin binding cellular component organization;cellular process;cytoplasmic microtubule organization;cytoskeleton organization;localization;microtubule cytoskeleton organization;microtubule-based process;organelle localization;organelle organization 5 5 5 9.6 9.6 9.6 83.125 1.8083E-49 22078000 11612000 10466000 2343 IPI:IPI00031768.1 Protein Hook homolog 3 HOOK3 Q86VS8 ENST00000307602 1 0.54212 1.0621 0.65502 0.72762 0.68894 0.88227 CSD cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;double-stranded DNA binding;nucleic acid binding;protein binding;RNA polymerase II transcription factor activity;transcription cofactor activity;transcription corepressor activity;transcription factor activity negative regulation of transcription from RNA polymerase II promoter;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription Tight junction 12 4 2 29.8 18.8 6.7 40.089 0 257400000 135500000 121900000 2344 IPI:IPI00031801.4;IPI:IPI00219148.2 DNA-binding protein A;Cold shock domain-containing protein A;Single-strand DNA-binding protein NF-GMB CSDA;DBPA P16989-1;P16989;P16989-3 ENST00000228251;ENST00000279550 K06099 2 0.79634 1.5183 0.79419 1.0538 1.0141 1.0601 Porin_3 cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial membrane;mitochondrial outer membrane;mitochondrial part;organelle membrane;organelle outer membrane;organelle part;outer membrane anion channel activity;anion transmembrane transporter activity;binding;ion channel activity;nucleotide binding;protein binding;transporter activity;voltage-gated anion channel activity;voltage-gated ion channel activity adenine transport;anion transport;establishment of localization;ion transport;nucleobase transport;nucleobase, nucleoside, nucleotide and nucleic acid transport;purine transport;transport Calcium signaling pathway;Huntington's disease;Parkinson's disease 13 13 13 50.5 50.5 50.5 30.658 5.547E-208 2006600000 1044000000 962630000 2345 IPI:IPI00031804.1;IPI:IPI00294779.1 Voltage-dependent anion-selective channel protein 3;Outer mitochondrial membrane protein porin 3 VDAC3 Q9Y277-1;Q9Y277;Q9Y277-2 ENST00000022615 K05862 2 0.62675 1.3682 0.71166 0.91696 0.86694 0.95385 CSD cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;double-stranded DNA binding;nucleic acid binding;protein binding;RNA binding;single-stranded DNA binding;structure-specific DNA binding;transcription factor activity;transcription regulator activity;transcription repressor activity nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile;transcription 14 14 6 50.3 50.3 37.7 35.924 0 5999800000 3198400000 2801400000 2346 IPI:IPI00031812.3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 1;Y-box transcription factor;YB-1;CCAAT-binding transcription factor I subunit A;Enhancer factor I subunit A;DNA-binding protein B YBX1;NSEP1;YB1 P67809 ENST00000321358 K09276 1 0.61263 1.0835 0.60019 0.77365 0.73895 0.77018 tRNA-synt_2d cell fraction;cell part;cytoplasm;intracellular part;soluble fraction aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-oxygen bonds;nucleoside binding;nucleotide binding;phenylalanine-tRNA ligase activity;purine nucleoside binding cellular amino acid and derivative metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;phenylalanyl-tRNA aminoacylation;tRNA aminoacylation for protein translation;tRNA metabolic process Aminoacyl-tRNA biosynthesis;Phenylalanine, tyrosine and tryptophan biosynthesis 16 16 16 41.7 41.7 41.7 57.563 0 1457700000 789330000 668370000 2347 IPI:IPI00031820.3 Phenylalanyl-tRNA synthetase alpha chain;Phenylalanine--tRNA ligase alpha chain;CML33 FARSA;FARS;FARSL;FARSLA Q9Y285 ENST00000314606 K01889 1 0.67319 1.3773 NaN 0.92563 0.91342 NaN SSF cell fraction;cell part;insoluble fraction;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane fraction;membrane part;plasma membrane part binding;cation transmembrane transporter activity;ion transmembrane transporter activity;secondary active transmembrane transporter activity;sodium-dependent multivitamin transmembrane transporter activity;symporter activity;transporter activity cation transport;establishment of localization;ion transport;metal ion transport;monovalent inorganic cation transport;sodium ion transport;transport 3 3 3 6.5 6.5 6.5 68.641 1.1699E-19 22180000 12203000 9976800 2348 IPI:IPI00031822.2 Sodium-dependent multivitamin transporter;Na(+)-dependent multivitamin transporter;Solute carrier family 5 member 6 SLC5A6;SMVT Q9Y289 ENST00000310574;ENST00000408041 1 0.75101 1.3132 0.65946 0.98483 0.87124 0.85444 MMR_HSR1;TGS cell part;cytoplasm;cytoskeleton;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;protein binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding;transcription factor binding biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;multicellular organismal development;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription 18 18 18 46 46 46 40.542 0 901360000 478790000 422570000 2349 IPI:IPI00031836.3 Developmentally-regulated GTP-binding protein 1;Neural precursor cell expressed developmentally down-regulated protein 3 DRG1;NEDD3 Q9Y295 ENST00000331457 1 0.56193 1.0809 0.49656 0.69734 0.72716 0.67206 RNA_pol_Rpb1_1;RNA_pol_Rpb1_2;RNA_pol_Rpb1_3;RNA_pol_Rpb1_4;RNA_pol_Rpb1_5 cell part;DNA-directed RNA polymerase complex;DNA-directed RNA polymerase I complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleolar part;nucleoplasm;organelle part;protein complex;RNA polymerase complex binding;catalytic activity;DNA binding;DNA-directed RNA polymerase activity;magnesium ion binding;nucleic acid binding;protein binding;transferase activity;transferase activity, transferring phosphorus-containing groups;zinc ion binding biosynthetic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription RNA polymerase 19 19 18 12.6 12.6 12 194.81 1.1808E-146 212160000 123420000 88743000 2350 IPI:IPI00031960.2 DNA-directed RNA polymerase I subunit RPA1;DNA-directed RNA polymerase I subunit A;DNA-directed RNA polymerase I largest subunit;RNA polymerase I 194 kDa subunit;A190 POLR1A O95602 ENST00000263857 K02999 1 0.84159 NaN 0.79227 1.0576 NaN 1.0289 LEM endoplasmic reticulum;integral to membrane;intracellular organelle;intrinsic to membrane;membrane;membrane-bounded organelle;nuclear inner membrane;nuclear membrane;organelle;organelle inner membrane;organelle membrane binding;protein binding anatomical structure development;developmental process;multicellular organismal process;muscle contraction;muscle organ development;muscle system process;organ development;system process 6 6 6 26 26 26 28.994 5.5814E-34 314800000 177580000 137220000 2351 IPI:IPI00032003.1 Emerin EMD;EDMD;STA P50402 ENST00000369842 1 0.66 1.2041 0.63173 0.84576 0.83405 0.79578 Carn_acyltransf cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial membrane;mitochondrial outer membrane;mitochondrial part;organelle membrane;organelle outer membrane;organelle part;outer membrane acyltransferase activity;carnitine O-acyltransferase activity;carnitine O-palmitoyltransferase activity;catalytic activity;O-acyltransferase activity;O-palmitoyltransferase activity;palmitoyltransferase activity;transferase activity catabolic process;cellular process;fatty acid beta-oxidation;fatty acid catabolic process;fatty acid metabolic process;lipid catabolic process;lipid metabolic process;metabolic process;organic acid metabolic process;transport Adipocytokine signaling pathway;Fatty acid metabolism;PPAR signaling pathway 21 21 21 29.4 29.4 29.4 88.367 3.3465E-222 794190000 426120000 368070000 2352 IPI:IPI00032038.4;IPI:IPI00479108.1 Carnitine O-palmitoyltransferase 1, liver isoform;Carnitine O-palmitoyltransferase I, liver isoform;Carnitine palmitoyltransferase 1A CPT1A;CPT1 P50416-1;P50416;P50416-2 ENST00000265641;ENST00000376618 K08765 2 0.80933 1.5845 1.0031 1.1283 0.93465 1.3174 GRAM;WWbp binding;protein binding 3 3 3 11.1 11.1 11.1 28.087 1.7324E-55 104620000 53814000 50805000 2353 IPI:IPI00032050.4 WW domain-binding protein 2 WBP2 Q969T9 ENST00000254806 1 NaN 1.5711 NaN NaN 1.0113 NaN C1-set;V-set cell part;integral to membrane;intrinsic to membrane;membrane;membrane part;plasma membrane binding;protein binding cell adhesion;cell communication;intracellular signaling cascade;positive regulation of immune system process;positive regulation of leukocyte activation;regulation of immune system process;regulation of leukocyte activation;signal transduction 3 3 3 11.4 11.4 11.4 42.497 3.3858E-22 3036000 1877700 1158300 2354 IPI:IPI00032061.3;IPI:IPI00783247.2;IPI:IPI00550753.1;IPI:IPI00218601.1 Signal-regulatory protein gamma;Signal-regulatory protein beta-2;CD172 antigen-like family member B SIRPG;SIRPB2 Q9P1W8-1;Q9P1W8;Q9P1W8-2;Q9P1W8-4 ENST00000303415;ENST00000344103;ENST00000381583 K06551 4 NaN NaN 0.81206 NaN NaN 1.0431 RII_binding_1 binding;enzyme binding;protein binding 2 2 2 1.9 1.9 1.9 122.07 0.0010156 9352800 4918700 4434100 2355 IPI:IPI00032064.1;IPI:IPI00816415.1;IPI:IPI00942356.1;IPI:IPI00914995.1;IPI:IPI00171217.2 A-kinase anchor protein 2;Protein kinase A-anchoring protein 2;AKAP-KL AKAP2;KIAA0920;PRKA2 Q9Y2D5-4;Q9Y2D5;Q9Y2D5-6;Q9Y2D5-7;Q9Y2D5-5;Q9Y2D5-3 ENST00000302798;ENST00000374525;ENST00000374530 5 0.97439 NaN NaN 1.1974 NaN NaN AMP-binding;DMAP_binding cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;protein binding;transcription factor binding metabolic process 2 1 1 1.2 0.5 0.5 170.77 2.4015E-10 10049000 3335000 6713500 2357 IPI:IPI00032087.4 Disco-interacting protein 2 homolog C DIP2C;KIAA0934 Q9Y2E4 ENST00000280886 1 0.85772 1.8186 1.8526 1.0586 1.2434 2.2508 Serpin cell part;cytoplasmic part;cytosol;intracellular part binding;endopeptidase inhibitor activity;enzyme inhibitor activity;enzyme regulator activity;peptidase inhibitor activity;protein binding;serine-type endopeptidase inhibitor activity 13 13 13 38 38 38 42.766 1.933E-185 266800000 146130000 120670000 2358 IPI:IPI00032134.2;IPI:IPI00032139.1;IPI:IPI00006640.3;IPI:IPI00027444.1;IPI:IPI00749398.1 Serpin B8;Cytoplasmic antiproteinase 2;Proteinase inhibitor 8 SERPINB8;PI8 P50452 ENST00000353706;ENST00000397985 5 NaN NaN 1.0342 NaN NaN 1.4436 O-FucT cell part;cytoplasmic part;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle catalytic activity;fucosyltransferase activity;peptide-O-fucosyltransferase activity;transferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring hexosyl groups alcohol metabolic process;carbohydrate metabolic process;fucose metabolic process;hexose metabolic process;metabolic process;monosaccharide metabolic process;primary metabolic process 2 2 2 5.6 5.6 5.6 49.975 4.5169E-27 727360 359580 367770 2359 IPI:IPI00218349.2;IPI:IPI00032138.4;IPI:IPI00218348.3 GDP-fucose protein O-fucosyltransferase 2;Peptide-O-fucosyltransferase 2 POFUT2;C21orf80;FUT13;KIAA0958 Q9Y2G5-3;Q9Y2G5;Q9Y2G5-1;Q9Y2G5-2 ENST00000331343;ENST00000334538;ENST00000349485 K03691 3 4.6387 8.3608 5.0412 6.0432 5.7339 6.2177 Serpin endoplasmic reticulum;endoplasmic reticulum lumen;ER-Golgi intermediate compartment;intracellular membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;membrane-enclosed lumen;organelle;organelle lumen;organelle part binding;collagen binding;endopeptidase inhibitor activity;enzyme inhibitor activity;enzyme regulator activity;peptidase inhibitor activity;protein binding;serine-type endopeptidase inhibitor activity response to biotic stimulus;response to chemical stimulus;response to organic substance;response to protein stimulus;response to stimulus;response to stress;response to unfolded protein 17 17 17 51.9 51.9 51.9 46.44 0 461300000 153680000 307610000 2360 IPI:IPI00032140.4 Serpin H1;Collagen-binding protein;47 kDa heat shock protein;Rheumatoid arthritis-related antigen RA-A47;Arsenic-transactivated protein 3;Cell proliferation-inducing gene 14 protein SERPINH1;CBP1;CBP2;HSP47;SERPINH2;PIG14 P50454 ENST00000358171 K09501 1 NaN 1.3711 NaN NaN 0.82997 NaN TPR_2 cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex binding;protein binding angiogenesis;N-terminal protein amino acid acetylation;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein amino acid acetylation;protein modification process;regulation of transcription, DNA-dependent;transcription 40 2 2 46.4 1.8 1.8 101.2 0 1982300 1139100 843140 2361 IPI:IPI00032158.3;IPI:IPI00413165.1 NMDA receptor-regulated protein 1;N-terminal acetyltransferase;Protein tubedown-1;Tbdn100;Gastric cancer antigen Ga19 NARG1;GA19;NATH;TBDN100 Q9BXJ9-4;Q9BXJ9 ENST00000296543 2 0.47745 0.89024 NaN 0.59482 0.61499 NaN LRR_1;PX cell part;cytoplasmic part;early endosome;endosome;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;organelle;plasma membrane;recycling endosome binding;lipid binding;phosphoinositide binding;phospholipid binding apoptosis;cell death;cellular process;death;programmed cell death 4 4 4 2.8 2.8 2.8 166.64 4.8831E-14 4012800 2089100 1923700 2362 IPI:IPI00032187.5;IPI:IPI00792206.1;IPI:IPI00795420.2;IPI:IPI00902963.1 Nischarin;Imidazoline receptor 1;Imidazoline-1 receptor;Imidazoline receptor antisera-selected protein;Imidazoline-1 receptor candidate protein NISCH;IRAS;KIAA0975 Q9Y2I1-1;Q9Y2I1;Q9Y2I1-2;Q9Y2I1-3;Q9Y2I1-4 ENST00000345716 4 0.91145 1.8549 0.82442 1.1639 1.2209 1.0531 Bromodomain;EPL1;PHD cell part;histone acetyltransferase complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding cellular component organization;cellular process;chromatin modification;chromatin organization;covalent chromatin modification;histone modification;metabolic process;organelle organization;protein amino acid acetylation;protein modification process 6 6 6 5.4 5.4 5.4 119.52 9.6548E-10 38512000 19111000 19402000 2364 IPI:IPI00032214.1 Bromodomain-containing protein 1;BR140-like protein BRD1;BRL;BRPF2 O95696 ENST00000216267;ENST00000404034;ENST00000404760 K11349 1 0.76107 1.5463 0.78154 1.0674 0.96524 1.0189 CH;efhand cell part;cytoplasm;intracellular part actin binding;actin filament binding;binding;calcium ion binding;cation binding;cytoskeletal protein binding;ion binding;metal ion binding;protein binding;structural constituent of cytoskeleton;structural molecule activity 13 11 9 24.5 21.1 17 70.253 2.3839E-96 119360000 68765000 50593000 2367 IPI:IPI00032304.2 Plastin-1;Intestine-specific plastin PLS1 Q14651 ENST00000337777 1 0.75178 NaN 0.64404 0.9189 NaN 0.7892 Pcc1 binding;protein binding 2 2 2 32.9 32.9 32.9 14.804 5.0642E-54 63200000 34047000 29154000 2368 IPI:IPI00032314.2 L antigen family member 3;Protein ITBA2;Protein ESO-3 LAGE3;DXS9879E;ESO3;ITBA2 Q14657 ENST00000357360 1 NaN NaN 0.059349 NaN NaN 0.078101 Cystatin cornified envelope;cytoplasm;cytoskeleton;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle binding;cysteine-type endopeptidase inhibitor activity;endopeptidase inhibitor activity;enzyme binding;enzyme inhibitor activity;enzyme regulator activity;peptidase inhibitor activity;protease binding;protein binding;structural molecule activity cell differentiation;cellular process;epidermal cell differentiation;keratinocyte differentiation;metabolic process;negative regulation of peptidase activity;peptide cross-linking;protein metabolic process;protein modification process 5 5 5 66.3 66.3 66.3 11.006 9.9594E-50 26269000 20549000 5719000 2369 IPI:IPI00032325.1 Cystatin-A;Cystatin-AS;Stefin-A CSTA;STF1;STFA P01040 ENST00000264474 1 0.67128 NaN 0.70755 1.0967 NaN 0.99847 cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;intracellular part;macromolecular complex;membrane;membrane part;nuclear membrane;nuclear part;nuclear pore;organelle membrane;organelle part;protein complex cellular process;establishment of protein localization;intracellular protein transport;intracellular transport;mRNA transport;nucleic acid transport;nucleobase, nucleoside, nucleotide and nucleic acid transport;protein transport;RNA transport;transport 2 2 1 3 3 2.1 125.06 1.32E-06 10582000 5659900 4922500 2370 IPI:IPI00032358.4 Nuclear envelope pore membrane protein POM 121C;Pore membrane protein of 121 kDa;Nuclear pore membrane protein 121-2 POM121C A8CG34 ENST00000257665 1 0.66796 1.419 0.71581 0.9161 0.90609 0.998 Alg6_Alg8 cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part alpha-1,3-mannosyltransferase activity;catalytic activity;mannosyltransferase activity;transferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring hexosyl groups carbohydrate metabolic process;cellular biopolymer metabolic process;cellular process;metabolic process;protein amino acid glycosylation;protein amino acid N-linked glycosylation;protein metabolic process;protein modification process 3 3 3 7.4 7.4 7.4 60.087 1.885E-08 46235000 24507000 21727000 2371 IPI:IPI00032370.5 Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase;Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase;Asparagine-linked glycosylation protein 8 ALG8;HUSSY-02 Q9BVK2 ENST00000299626 1 0.73464 0.33537 0.71779 1.0199 0.21467 1.0338 FCH;SH3_1;WW cell part;cytoplasm;intracellular part binding;DNA binding;nucleic acid binding;protein binding;transcription factor activity;transcription regulator activity anatomical structure development;cell cycle arrest;cell cycle process;cell differentiation;cellular developmental process;cellular process;developmental process;nervous system development;system development 3 3 3 6.9 6.9 6.9 54.371 1.0743E-12 26113000 8164100 17949000 2372 IPI:IPI00398632.2;IPI:IPI00032371.3;IPI:IPI00216089.1 Growth arrest-specific protein 7 GAS7;KIAA0394 O60861-3;O60861;O60861-1;O60861-2 ENST00000323816;ENST00000396115 3 0.5732 1.1856 0.64956 0.79441 0.82358 0.7868 Psf1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle biosynthetic process;cellular process;DNA metabolic process;DNA replication;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 6 6 6 36.2 36.2 36.2 22.988 6.7903E-75 44774000 27033000 17742000 2373 IPI:IPI00032387.1 DNA replication complex GINS protein PSF1;GINS complex subunit 1 GINS1;KIAA0186;PSF1 Q14691 ENST00000262460 K10732 1 1.632 2.835 1.4717 2.2087 1.821 1.9454 Lipin_N;LNS2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 3 3 3 4.8 4.8 4.8 99.442 4.0402E-23 9729900 4440200 5289700 2374 IPI:IPI00032388.5 Lipin-1 LPIN1;KIAA0188 Q14693 ENST00000256720;ENST00000396099 1 0.84598 1.5745 0.85382 1.1507 1.0245 1.147 SH2 cell part;cytoplasm;intracellular part binding;molecular adaptor activity;molecular transducer activity;protein binding;protein binding, bridging;SH3/SH2 adaptor activity;signal transducer activity cell communication;cell-cell signaling;cellular defense response;cellular process;defense response;response to stimulus;response to stress Natural killer cell mediated cytotoxicity 7 7 7 67.2 67.2 67.2 14.187 1.0483E-174 1047300000 537880000 509390000 2375 IPI:IPI00032401.1;IPI:IPI00216637.1;IPI:IPI00873008.1;IPI:IPI00216635.1;IPI:IPI00216639.1;IPI:IPI00216636.1 SH2 domain-containing protein 1A;Signaling lymphocytic activation molecule-associated protein;T-cell signal transduction molecule SAP;Duncan disease SH2-protein SH2D1A;DSHP;SAP O60880-1;O60880;O60880-4 ENST00000371139;ENST00000394476 K07990 6 0.77672 1.6247 0.79654 1.0508 1.0057 1.0555 DnaJ;DnaJ_C;DnaJ_CXXCXGXG cell part;membrane binding;cation binding;heat shock protein binding;ion binding;metal ion binding;protein binding;transition metal ion binding;unfolded protein binding;zinc ion binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular process;macromolecule metabolic process;metabolic process;positive regulation of cell proliferation;protein folding;protein metabolic process;regulation of cell proliferation 10 10 10 38.8 38.8 38.8 45.745 3.1724E-61 792290000 412790000 379500000 2376 IPI:IPI00032406.1 DnaJ homolog subfamily A member 2;HIRA-interacting protein 4;Cell cycle progression restoration gene 3 protein;Dnj3;Renal carcinoma antigen NY-REN-14 DNAJA2;CPR3;HIRIP4 O60884 ENST00000317089 K09503 1 0.85061 2.0223 0.88141 1.1083 1.338 1.1808 Robl_LC7 cell part;cytoplasmic part;endosomal part;endosome membrane;intracellular organelle part;intracellular part;late endosome membrane;lysosomal membrane;membrane;organelle membrane;organelle part;vacuolar membrane;vacuolar part 3 3 3 22 22 22 15.609 2.7832E-19 55739000 29421000 26318000 2377 IPI:IPI00477441.1;IPI:IPI00032409.1 Mitogen-activated protein-binding protein-interacting protein;Late endosomal/lysosomal Mp1-interacting protein;Roadblock domain-containing protein 3;Endosomal adaptor protein p14 ROBLD3;MAPBPIP;HSPC003 Q9Y2Q5-2;Q9Y2Q5;Q9Y2Q5-1 ENST00000368302;ENST00000368305 2 0.5177 1.0367 0.46025 0.67973 0.67778 0.61455 DEAD;Helicase_C cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part ATP binding;ATP-dependent helicase activity;binding;catalytic activity;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity;RNA binding Folate biosynthesis 10 10 10 20.2 20.2 20.2 67.465 3.6987E-114 147970000 81631000 66334000 2378 IPI:IPI00032423.2 Probable ATP-dependent RNA helicase DDX52;DEAD box protein 52;ATP-dependent RNA helicase ROK1-like DDX52;ROK1;HUSSY-19 Q9Y2R4 ENST00000349699 K01529 1 0.82391 2.3262 0.77888 1.0077 1.5571 0.95324 Memo cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 5 5 5 20.9 20.9 20.9 33.733 4.9126E-70 54394000 29745000 24649000 2379 IPI:IPI00032426.1 Protein MEMO1;Mediator of ErbB2-driven cell motility 1;Hepatitis C virus NS5A-transactivated protein 7;C21orf19-like protein MEMO1;C2orf4;NS5ATP7;CGI-27 Q9Y316 ENST00000295065;ENST00000379383;ENST00000404530 1 0.56567 1.0671 0.66378 0.75171 0.75385 0.78048 RNA_pol_L cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;catalytic activity;DNA binding;DNA-directed RNA polymerase activity;nucleic acid binding;nucleotidyltransferase activity;protein binding;RNA polymerase activity;transferase activity;transferase activity, transferring phosphorus-containing groups biosynthetic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription RNA polymerase 4 4 3 39.1 39.1 31.6 15.237 1.8185E-59 87090000 48815000 38275000 2380 IPI:IPI00032439.1 DNA-directed RNA polymerases I and III subunit RPAC2;DNA-directed RNA polymerase I 16 kDa polypeptide;RPC16;hRPA19;AC19 POLR1D Q9Y2S0-1;Q9Y2S0 ENST00000302979;ENST00000399696;ENST00000399697 K03020 1 0.84371 1.6398 0.85313 1.0981 1.1207 1.0532 Adap_comp_sub;Clat_adaptor_s AP-type membrane coat adaptor complex;clathrin adaptor complex;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;lysosome;lytic vacuole;macromolecular complex;membrane-bounded organelle;organelle;protein complex;vacuole binding;protein binding cellular process;intracellular protein transport;lysosomal transport;protein targeting;protein targeting to lysosome;protein targeting to vacuole;protein transport;transport;vacuolar transport;vesicle-mediated transport 3 3 3 7.2 7.2 7.2 46.939 1.4416E-05 33130000 17271000 15859000 2381 IPI:IPI00032459.1;IPI:IPI00022883.1 AP-3 complex subunit mu-1;Adapter-related protein complex 3 mu-1 subunit;AP-3 adapter complex mu3A subunit;Mu-adaptin 3A;Mu3A-adaptin AP3M1 Q9Y2T2 ENST00000355264;ENST00000372745 K12398 2 0.74312 1.7162 0.7637 1.022 1.0959 1.0162 LSM cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;RNA binding;snRNA binding;U6 snRNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 8 8 8 82.1 82.1 82.1 10.834 2.8732E-203 864690000 416030000 448660000 2382 IPI:IPI00032460.3 U6 snRNA-associated Sm-like protein LSm2;snRNP core Sm-like protein Sm-x5;Small nuclear ribonuclear protein D homolog;Protein G7b LSM2;C6orf28;G7B Q9Y333 ENST00000229715;ENST00000375661;ENST00000383391 1 0.62161 1.6397 NaN 0.8936 1.0066 NaN Pro_isomerase cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;catalytic activity;cis-trans isomerase activity;isomerase activity;peptidyl-prolyl cis-trans isomerase activity;protein binding cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein folding;RNA metabolic process;RNA processing;RNA splicing 4 4 4 31.5 31.5 31.5 18.627 7.9043E-14 46447000 26534000 19913000 2383 IPI:IPI00032473.1;IPI:IPI00300952.3 Peptidyl-prolyl cis-trans isomerase-like 3;Cyclophilin-like protein PPIL3;Cyclophilin J PPIL3 Q9H2H8-2;Q9H2H8;Q9H2H8-1 ENST00000234288;ENST00000286175;ENST00000392283;ENST00000409264 K01802 2 0.66592 1.3061 0.88047 0.8374 0.92572 1.1352 LEM;MAN1_C cell fraction;insoluble fraction;integral to membrane;integral to nuclear inner membrane;integral to organelle membrane;intrinsic to membrane;intrinsic to nuclear inner membrane;intrinsic to organelle membrane;membrane fraction;organelle part binding;DNA binding;nucleic acid binding;nucleotide binding 5 5 5 7.2 7.2 7.2 99.996 5.132E-17 41832000 23302000 18529000 2384 IPI:IPI00032491.1 Inner nuclear membrane protein Man1;LEM domain-containing protein 3 LEMD3;MAN1 Q9Y2U8 ENST00000308330 1 0.88077 1.9144 NaN 1.1764 1.2688 NaN Hexapep cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle catalytic activity;transferase activity 3 3 3 17.6 17.6 17.6 20.126 4.0518E-54 27995000 15645000 12350000 2385 IPI:IPI00032498.1 Dynactin subunit 5;Dynactin subunit p25 DCTN5 Q9BTE1 ENST00000300087 K10427 1 0.60246 1.5033 0.49204 0.85962 0.91003 0.69364 2 2 2 34 34 34 10.859 7.6599E-49 89585000 49210000 40375000 2386 IPI:IPI00032506.2 Uncharacterized protein C14orf142 C14orf142 Q9BXV9 ENST00000306954 1 0.88186 1.6074 0.85073 1.1002 1.0883 1.0336 Adap_comp_sub AP-type membrane coat adaptor complex;clathrin adaptor complex;clathrin coated vesicle membrane;coated vesicle membrane;cytoplasmic vesicle membrane;cytosol;Golgi apparatus;macromolecular complex;membrane;organelle;organelle membrane;vesicle membrane binding;protein binding cellular process;establishment of localization;establishment of localization in cell;establishment of protein localization;intracellular protein transport;intracellular transport;protein transport;transport;vesicle-mediated transport 16 16 16 48.5 48.5 48.5 48.586 5.0428E-164 555660000 297660000 258000000 2387 IPI:IPI00032516.5;IPI:IPI00219794.5;IPI:IPI00002552.2 AP-1 complex subunit mu-1;Adaptor-related protein complex 1 mu-1 subunit;Adaptor protein complex AP-1 mu-1 subunit;Golgi adaptor HA1/AP1 adaptin mu-1 subunit;Mu-adaptin 1;AP-mu chain family member mu1A;Mu1A-adaptin;Clathrin assembly protein complex 1 medium chain 1;Clathrin coat assembly protein AP47;Clathrin coat-associated protein AP47 AP1M1;CLTNM Q9BXS5 ENST00000291439 3 0.52443 1.0191 0.45417 0.66525 0.69884 0.60502 WD40 8 8 8 20.8 20.8 20.8 47.405 1.4331E-32 77213000 46194000 31019000 2388 IPI:IPI00032533.3 WD repeat-containing protein 18 WDR18 Q9BV38 ENST00000251289 1 0.75598 1.4293 0.81792 1.0341 0.84999 1.1252 CIA30 cytoplasmic part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;mitochondrial membrane part;mitochondrial part;mitochondrial respiratory chain complex I;NADH dehydrogenase complex;organelle part;protein complex binding;protein binding;unfolded protein binding anatomical structure formation;cellular component assembly;cellular component organization;cellular process;generation of precursor metabolites and energy;metabolic process;mitochondrial electron transport, NADH to ubiquinone;protein complex assembly 3 3 3 10.1 10.1 10.1 37.763 2.4728E-23 18072000 9501000 8570900 2389 IPI:IPI00032560.2 Complex I intermediate-associated protein 30, mitochondrial;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 1 NDUFAF1;CIA30;CGI-65 Q9Y375 ENST00000260361 1 0.86146 1.6731 0.89125 1.1002 1.1199 1.1836 Mo25 cell part;cytoplasm;intracellular part binding;protein binding mTOR signaling pathway 11 11 11 31.7 31.7 31.7 39.869 6.6942E-48 254100000 128470000 125630000 2390 IPI:IPI00032561.1;IPI:IPI00026359.4 Calcium-binding protein 39;Protein Mo25 CAB39;MO25;CGI-66 Q9Y376 ENST00000258418;ENST00000409788;ENST00000410084 K08272 2 0.6272 NaN 0.75948 0.8606 NaN 1.013 zf-C2H2 cell part;DNA-directed RNA polymerase complex;DNA-directed RNA polymerase II, core complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;RNA polymerase complex binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;RNA polymerase II transcription factor activity;specific RNA polymerase II transcription factor activity;transcription regulator activity;zinc ion binding negative regulation of transcription from RNA polymerase II promoter;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 3 3 3 5.5 5.5 5.5 96.914 8.1537E-45 2014300 998620 1015600 2391 IPI:IPI00032563.3 Zinc finger protein 281;Zinc finger DNA-binding protein 99;Transcription factor ZBP-99;GC-box-binding zinc finger protein 1 ZNF281;GZP1;ZBP99 Q9Y2X9 ENST00000294740;ENST00000367353 1 0.75983 1.6936 0.78169 1.0147 1.1043 1.0473 Glyoxalase cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle 16 16 16 50.5 50.5 50.5 34.793 1.0366E-241 1102900000 608840000 494100000 2392 IPI:IPI00032575.3;IPI:IPI00745272.3;IPI:IPI00792035.1 Glyoxalase domain-containing protein 4 GLOD4;C17orf25;CGI-150;My027 Q9HC38-1;Q9HC38;Q9HC38-2;Q9HC38-3 ENST00000301328;ENST00000301329;ENST00000397393 3 0.81405 1.8093 0.80898 1.1282 1.1596 1.0436 RRM_1 binding;nucleic acid binding;nucleotide binding;RNA binding 3 3 3 10.2 10.2 10.2 37.335 3.2767E-26 40352000 19697000 20655000 2393 IPI:IPI00032597.2 RNA-binding motif protein, X-linked 2 RBMX2;CGI-79 Q9Y388 ENST00000257020;ENST00000305536 1 0.4546 NaN NaN 0.54445 NaN NaN GIDA cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle adenyl nucleotide binding;binding;coenzyme binding;cofactor binding;FAD binding;nucleoside binding;nucleotide binding;purine nucleoside binding;purine nucleotide binding cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;tRNA metabolic process;tRNA processing 3 3 3 4.7 4.7 4.7 79.963 1.3321E-06 10321000 5343600 4977800 2394 IPI:IPI00032630.2;IPI:IPI00215953.1;IPI:IPI00215954.1;IPI:IPI00180380.2;IPI:IPI00233661.1 Protein MTO1 homolog, mitochondrial MTO1;CGI-02 Q9Y2Z2-1;Q9Y2Z2;Q9Y2Z2-4;Q9Y2Z2-5;Q9Y2Z2-2 ENST00000357845;ENST00000370300;ENST00000370308 K03495 5 0.68964 1.5035 0.7036 0.90602 0.96466 0.9353 FAD_binding_3 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle binding;catalytic activity;monooxygenase activity;nucleoside binding;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;purine nucleoside binding biosynthetic process;cellular ketone metabolic process;cellular process;coenzyme biosynthetic process;coenzyme metabolic process;metabolic process;oxidoreduction coenzyme metabolic process;ubiquinone biosynthetic process;ubiquinone metabolic process Ubiquinone and menaquinone biosynthesis 2 2 2 4.7 4.7 4.7 50.869 6.2976E-06 14810000000 8268200000 6541400000 2395 IPI:IPI00032633.4 Ubiquinone biosynthesis monooxygenase COQ6 COQ6;CGI-10 Q9Y2Z9 ENST00000334571 K06126 1 0.69349 1.3599 0.62604 0.96931 0.84907 0.91921 DFDF;FFD_TFG 4 4 4 11.4 11.4 11.4 42.07 2.3488E-19 39661000 21849000 17812000 2396 IPI:IPI00032635.1;IPI:IPI00448024.2 Protein LSM14 homolog B;Protein FAM61B LSM14B;C20orf40;FAM61B Q9BX40-1;Q9BX40;Q9BX40-2 ENST00000253001;ENST00000279068 2 0.66275 1.3196 0.66067 0.91494 0.88775 0.78595 UPF0086 intracellular part;macromolecular complex;multimeric ribonuclease P complex;nuclear part;nucleolar ribonuclease P complex;organelle part;ribonuclease MRP complex;ribonuclease P complex;ribonucleoprotein complex;small nucleolar ribonucleoprotein complex binding;catalytic activity;endonuclease activity;endoribonuclease activity;hydrolase activity;nuclease activity;nucleic acid binding;protein binding;ribonuclease activity;ribonuclease P activity;RNA binding;tRNA-specific ribonuclease activity cellular process;metabolic process;mRNA cleavage;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA processing;rRNA processing;tRNA metabolic process;tRNA processing 4 4 4 19.5 19.5 19.5 25.424 8.377E-11 29132000 15848000 13284000 2397 IPI:IPI00032791.4 Ribonuclease P protein subunit p29 POP4;RPP29 O95707 ENST00000221770 K03538 1 0.86405 1.8397 0.99643 1.1603 1.1636 1.333 Ras cell part;clathrin-coated vesicle;coated vesicle;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;intracellular organelle;membrane;membrane-bounded organelle;membrane-bounded vesicle;organelle;plasma membrane;synaptic vesicle;vesicle binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity cell communication;cellular process;establishment of protein localization;exocytosis;intracellular signaling cascade;protein transport;secretion by cell;signal transduction;small GTPase mediated signal transduction;transport;vesicle-mediated transport 7 4 4 27.9 18.3 18.3 24.267 2.7365E-67 77473000 38882000 38591000 2398 IPI:IPI00032808.1;IPI:IPI00023504.1;IPI:IPI00061114.1;IPI:IPI00300562.2 Ras-related protein Rab-3D;Ras-related protein Rab-3A;Ras-related protein Rab-3C RAB3D;GOV;RAB16;RAB3A;RAB3C O95716;P20336;Q96E17 ENST00000222120;ENST00000222256;ENST00000282878 K07884;K07882;K07883 4 0.74141 1.1427 0.76108 0.96674 0.81447 0.93283 EXOSC1 exosome (RNase complex);intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;protein complex binding;catalytic activity;exonuclease activity;hydrolase activity;hydrolase activity, acting on ester bonds;nuclease activity;nucleic acid binding;protein binding;RNA binding cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 4 4 4 26.2 26.2 26.2 21.452 1.143E-134 78198000 40396000 37802000 2399 IPI:IPI00032823.1 3'-5' exoribonuclease CSL4 homolog;Exosome component 1 EXOSC1;CSL4;CGI-108 Q9Y3B2 ENST00000370902 1 0.96912 1.9098 0.94078 1.232 1.3359 1.2482 EMP24_GP25L cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part establishment of localization;transport 5 5 5 29 29 29 25.171 6.1161E-28 292510000 150250000 142260000 2400 IPI:IPI00032825.2 Transmembrane emp24 domain-containing protein 7 TMED7;CGI-109 Q9Y3B3 ENST00000282382;ENST00000408996 1 1.1104 2.2098 1.1519 1.4563 1.4273 1.5138 TPR_1 cell part;cytoplasm;intracellular part binding;protein binding;protein binding, bridging biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 16 16 16 33.3 33.3 33.3 41.331 0 5829100000 2924100000 2905000000 2401 IPI:IPI00032826.1;IPI:IPI00168839.1;IPI:IPI00218038.1 Hsc70-interacting protein;Suppression of tumorigenicity protein 13;Putative tumor suppressor ST13;Protein FAM10A1;Progesterone receptor-associated p48 protein;Renal carcinoma antigen NY-REN-33;Protein FAM10A5;Protein FAM10A4 ST13;FAM10A1;HIP;SNC6;FAM10A5;FAM10A4 P50502;Q8NFI4;Q8IZP2 ENST00000216218;ENST00000391478 K09560 3 0.84699 1.4386 0.88152 1.0922 0.95156 1.1455 RRM_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 6 6 6 52 52 52 14.585 3.3386E-140 357620000 186200000 171420000 2402 IPI:IPI00032827.1 Pre-mRNA branch site protein p14;SF3B 14 kDa subunit SF3B14;CGI-110;HSPC175;HT006 Q9Y3B4 ENST00000233468 1 0.74974 1.513 0.68144 1.0159 0.95355 0.92889 Exonuc_X-T cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;nucleus;organelle 3'-5' exonuclease activity;binding;catalytic activity;cation binding;exonuclease activity;hydrolase activity;hydrolase activity, acting on ester bonds;ion binding;manganese ion binding;metal ion binding;nuclease activity;nucleic acid binding cellular metabolic process;cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;nucleotide metabolic process 11 11 11 38 38 38 26.832 6.5738E-123 458910000 247180000 211730000 2403 IPI:IPI00032830.2;IPI:IPI00217330.2 Oligoribonuclease, mitochondrial;Small fragment nuclease;RNA exonuclease 2 homolog REXO2;SFN;SMFN;CGI-114 Q9Y3B8-1;Q9Y3B8;Q9Y3B8-2 ENST00000265881 2 0.74547 1.3881 0.85943 1.0397 0.8994 1.1307 SNAP-25;SNARE cell fraction;cell junction;cell part;cytoplasm;insoluble fraction;intracellular part;membrane fraction;membrane part;plasma membrane part;synapse;synaptosome binding;protein binding;SNAP receptor activity cellular component organization;cellular process;establishment of protein localization;exocytosis;membrane fusion;membrane organization;protein transport;secretion;secretion by cell;transport;vesicle targeting;vesicle-mediated transport SNARE interactions in vesicular transport 8 8 8 30.2 30.2 30.2 28.97 2.9882E-68 121480000 61600000 59881000 2404 IPI:IPI00032831.4 Synaptosomal-associated protein 29;Vesicle-membrane fusion protein SNAP-29;Soluble 29 kDa NSF attachment protein SNAP29 O95721 ENST00000215730 K08509 1 0.68477 1.3171 0.77406 0.93992 0.87983 1.0596 DUF2360 3 3 3 17 17 17 21.172 2.5938E-32 12880000 7152300 5727900 2405 IPI:IPI00032848.1 Coiled-coil domain-containing protein 53 CCDC53;AD-016;CGI-116;x0009 Q9Y3C0 ENST00000240079 1 0.46812 1.1952 0.64419 0.64249 0.74324 0.8659 Nop16 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part 7 7 7 43.3 43.3 43.3 21.188 6.9617E-150 240050000 131960000 108080000 2406 IPI:IPI00032849.2 Nucleolar protein 16;HBV pre-S2 trans-regulated protein 3 NOP16;CGI-117;HSPC111 Q9Y3C1 ENST00000341213;ENST00000389158 1 0.98555 1.985 0.95458 1.3671 1.246 1.3219 Clat_adaptor_s cell part;COPI vesicle coat;cytoplasmic part;cytoplasmic vesicle part;cytosol;Golgi apparatus part;intracellular organelle part;intracellular part;macromolecular complex;membrane coat;membrane part;organelle part;protein complex;vesicle coat binding;protein binding cellular component organization;cellular process;intracellular protein transport;intra-Golgi vesicle-mediated transport;organelle organization;protein transport;retrograde vesicle-mediated transport, Golgi to ER;transport;vesicle coating 6 6 6 36.7 36.7 36.7 20.198 3.7403E-29 407130000 208900000 198230000 2407 IPI:IPI00032851.1 Coatomer subunit zeta-1;Zeta-1-coat protein COPZ1;COPZ;CGI-120;HSPC181 P61923 ENST00000262061 1 0.59929 1.3788 0.58127 0.74247 0.85307 0.84085 Nop10p Cajal body;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nuclear body;nucleolus;organelle;organelle part;ribonucleoprotein complex;small nucleolar ribonucleoprotein complex binding;protein binding cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;pseudouridine synthesis;RNA metabolic process;RNA modification;RNA processing;rRNA processing 3 3 3 42.2 42.2 42.2 7.7059 1.5005E-22 171250000 93086000 78165000 2408 IPI:IPI00032853.1 H/ACA ribonucleoprotein complex subunit 3;snoRNP protein NOP10;Nucleolar protein 10;Nucleolar protein family A member 3 NOP10;NOLA3 Q9NPE3 ENST00000328848 K11130 1 0.61709 1.5176 0.6292 0.86746 0.92968 0.92057 Ribosomal_S16 cytoplasmic part;intracellular part;macromolecular complex;mitochondrial part;mitochondrial small ribosomal subunit;organellar small ribosomal subunit;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 3 3 3 29.9 29.9 29.9 15.345 1.3783E-38 95175000 51582000 43593000 2409 IPI:IPI00032872.3 28S ribosomal protein S16, mitochondrial;MRP-S16 MRPS16;RPMS16;CGI-132 Q9Y3D3 ENST00000372945 1 0.68064 1.4046 0.75584 0.90323 0.94714 0.98188 ETF_QO;Pyr_redox_2 cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part binding;catalytic activity;electron carrier activity;electron-transferring-flavoprotein dehydrogenase activity;iron ion binding;oxidoreductase activity;oxidoreductase activity, acting on the CH-NH group of donors cellular metabolic process;cellular process;electron transport chain;establishment of localization;generation of precursor metabolites and energy;metabolic process;oxidation reduction;transport 7 7 7 13.6 13.6 13.6 68.507 6.7963E-45 89068000 46770000 42299000 2410 IPI:IPI00032875.1 Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial;Electron-transferring-flavoprotein dehydrogenase ETFDH Q16134 ENST00000307738;ENST00000355672 K00311 1 0.78585 1.2656 0.75239 1.0008 0.8562 0.97977 AAA cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle adenylate kinase activity;ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups Basal transcription factors 5 5 5 33.7 33.7 33.7 20.061 9.3845E-72 139440000 72012000 67425000 2411 IPI:IPI00032879.1 Adenylate kinase isoenzyme 6;ATP-AMP transphosphorylase 6 AK6;AD-004;CGI-137 Q9Y3D8 ENST00000380822 K03133 1 0.68937 1.3798 0.67807 0.87276 0.95552 0.90183 MRP-S23 intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;mitochondrion;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome 5 5 5 27.4 27.4 27.4 21.77 1.334E-28 150790000 79765000 71029000 2412 IPI:IPI00032881.2 28S ribosomal protein S23, mitochondrial;MRP-S23 MRPS23;CGI-138;HSPC329 Q9Y3D9 ENST00000313608 1 0.63468 1.5317 NaN 0.84819 0.98392 NaN polyprenyl_synt cell fraction;cell part;cytoplasm;intracellular part;soluble fraction catalytic activity;dimethylallyltranstransferase activity;farnesyltranstransferase activity;geranyltranstransferase activity;prenyltransferase activity;transferase activity;transferase activity, transferring alkyl or aryl (other than methyl) groups biosynthetic process;cellular biosynthetic process;cellular metabolic process;cellular process;isoprenoid biosynthetic process;isoprenoid metabolic process;lipid biosynthetic process;lipid metabolic process;metabolic process;primary metabolic process Biosynthesis of steroids;Terpenoid biosynthesis 2 2 2 7.3 7.3 7.3 34.87 1.2575E-05 18736000 10827000 7909200 2413 IPI:IPI00032892.1 Geranylgeranyl pyrophosphate synthetase;Geranylgeranyl diphosphate synthase;Dimethylallyltranstransferase;Geranyltranstransferase;Farnesyltranstransferase GGPS1 O95749 ENST00000282841;ENST00000358966 K00787;K00795;K00804 1 0.57184 1.0427 0.69874 0.78151 0.66397 0.83456 BolA cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding 5 5 5 57.7 57.7 57.7 14.289 4.0974E-224 117350000 64240000 53111000 2414 IPI:IPI00032900.1 BolA-like protein 1 BOLA1;CGI-143 Q9Y3E2 ENST00000369150;ENST00000369152;ENST00000369153 1 0.60979 1.3322 0.65961 0.81414 0.84086 0.91835 PTH2 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle aminoacyl-tRNA hydrolase activity;carboxylesterase activity;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds apoptosis;biosynthetic process;cell death;cellular macromolecule biosynthetic process;cellular process;death;macromolecule biosynthetic process;metabolic process;programmed cell death;protein metabolic process;translation 5 5 5 37.4 37.4 37.4 19.193 1.6593E-252 78246000 43168000 35078000 2415 IPI:IPI00032903.3 Peptidyl-tRNA hydrolase 2, mitochondrial;Bcl-2 inhibitor of transcription 1 PTRH2;BIT1;PTH2;CGI-147 Q9Y3E5 ENST00000311824;ENST00000393038;ENST00000409433 K04794 1 0.82287 1.6856 0.83993 1.0806 1.073 1.0954 Sec1 cell part;cytoplasmic part;endosomal part;endosome membrane;intracellular organelle part;intracellular part;late endosome membrane;lysosomal membrane;membrane;organelle membrane;organelle part;vacuolar membrane;vacuolar part cellular process;establishment of localization;establishment of protein localization;membrane docking;protein transport;transport;vesicle docking;vesicle docking during exocytosis 15 15 15 29.7 29.7 29.7 70.615 1.0328E-216 135580000 75552000 60027000 2416 IPI:IPI00032905.2 Vacuolar protein sorting-associated protein 33B VPS33B Q9H267 ENST00000333371 1 0.81583 1.3564 0.81481 1.0457 0.86543 1.053 TBP cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex;transcription factor TFIID complex binding;DNA binding;nucleic acid binding;protein binding;RNA polymerase II transcription factor activity;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding cellular process;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of transcription, DNA-dependent;transcription initiation;transcription initiation from RNA polymerase II promoter Basal transcription factors;Huntington's disease 6 6 6 43.5 43.5 43.5 20.886 3.6175E-95 30524000 16268000 14256000 2417 IPI:IPI00032911.3;IPI:IPI00165008.2;IPI:IPI00869301.1 TATA box-binding protein-like protein 1;TATA box-binding protein-related factor 2;TBP-related protein;TBP-like factor;21 kDa TBP-like protein;Second TBP of unique DNA protein TBPL1;TLF;TLP;TLP21;TRF2;TRP P62380 ENST00000237264 K03120 3 0.78166 1.4755 0.81251 1.0299 0.9615 1.0635 zf-C3HC4 cell part;intracellular binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding cell differentiation;cellular developmental process;cellular process;developmental process;gamete generation;male gamete generation;multicellular organismal development;multicellular organismal process;reproductive process;spermatogenesis 4 4 4 17.1 17.1 17.1 25.694 1.0413E-31 140580000 71712000 68867000 2418 IPI:IPI00032955.1;IPI:IPI00908327.1 RING finger protein 114;Zinc finger protein 313 RNF114;ZNF228;ZNF313 Q9Y508-1;Q9Y508;Q9Y508-2 ENST00000244061 2 0.79115 1.4799 0.87455 1.0708 0.95155 1.1811 UQ_con cell part;chromosomal part;intracellular organelle part;intracellular part;nuclear body;nuclear chromosome part;nuclear part;nucleoplasm part;organelle part;PML body;synaptonemal complex ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleoside binding;nucleotide binding;purine nucleoside binding;specific transcriptional repressor activity;transcription repressor activity catabolic process;chromosome segregation;metabolic process;mitosis;nuclear division;organelle organization;protein modification process;proteolysis;regulation of transcription, DNA-dependent;ubiquitin-dependent protein catabolic process Ubiquitin mediated proteolysis 9 9 9 60.8 60.8 60.8 18.007 3.8636E-154 1504500000 778420000 726120000 2419 IPI:IPI00032957.1 SUMO-conjugating enzyme UBC9;SUMO-protein ligase;Ubiquitin-conjugating enzyme E2 I;Ubiquitin-protein ligase I;Ubiquitin carrier protein I;Ubiquitin carrier protein 9;p18 UBE2I;UBC9;UBCE9 P63279 ENST00000325437;ENST00000355803;ENST00000397514;ENST00000397515;ENST00000402301;ENST00000403747;ENST00000406620 K10577 1 1.755 3.5324 1.6875 2.4782 2.2803 2.2198 PH cell division site part;contractile ring;cytoplasmic part;cytoskeletal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;nucleus;organelle;organelle part actin binding;binding;cytoskeletal protein binding;protein binding cellular process;cytokinesis;mitosis;nuclear division;organelle organization;protein complex assembly;regulation of cell cycle process;regulation of exit from mitosis;regulation of mitosis;regulation of mitotic cell cycle;septin ring assembly 14 14 14 15.9 15.9 15.9 124.2 3.8622E-68 69029000 31879000 37150000 2420 IPI:IPI00657687.1;IPI:IPI00032958.3 Actin-binding protein anillin ANLN Q9NQW6-1;Q9NQW6;Q9NQW6-2 ENST00000265748;ENST00000396068 2 0.70991 1.8867 0.69615 0.93121 1.2197 0.93033 NAD_Gly3P_dh_C;NAD_Gly3P_dh_N cell part;cytoplasmic part;glycerol-3-phosphate dehydrogenase complex;intracellular part;macromolecular complex;protein complex binding;catalytic activity;glycerol-3-phosphate dehydrogenase (NAD+) activity;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;protein binding alcohol metabolic process;carbohydrate metabolic process;catabolic process;glycerol metabolic process;glycerol-3-phosphate metabolic process;macromolecule catabolic process;metabolic process;phosphate metabolic process;phosphorus metabolic process Glycerophospholipid metabolism 10 10 10 28.5 28.5 28.5 38.418 5.4822E-76 69500000 35806000 33694000 2421 IPI:IPI00032959.3 Glycerol-3-phosphate dehydrogenase 1-like protein GPD1L;KIAA0089 Q8N335 ENST00000282541 K00006 1 0.6495 1.5618 0.70785 0.9183 0.9792 0.92095 Oxysterol_BP;PH biosynthetic process;cellular biosynthetic process;cellular lipid metabolic process;cellular metabolic process;cellular process;lipid metabolic process;lipid transport;metabolic process;primary metabolic process;steroid metabolic process;transport 8 8 8 15.5 15.5 15.5 83.642 1.3585E-46 43090000 23583000 19507000 2423 IPI:IPI00032970.2;IPI:IPI00032971.2 Oxysterol-binding protein-related protein 11 OSBPL11;ORP11;OSBP12 Q9BXB4 ENST00000296220 2 0.74484 1.9274 0.89023 0.98431 1.2316 1.2124 LANC_like cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;nucleus;organelle;plasma membrane adenyl nucleotide binding;ATP binding;binding;catalytic activity;GTP binding;guanyl nucleotide binding;nucleoside binding;nucleotide binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding negative regulation of biosynthetic process;negative regulation of metabolic process;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process 5 5 5 13.1 13.1 13.1 50.854 4.2707E-22 30687000 16542000 14145000 2424 IPI:IPI00032995.1 LanC-like protein 2;Testis-specific adriamycin sensitivity protein LANCL2;GPR69B;TASP Q9NS86 ENST00000254770 1 0.82366 0.72078 0.1542 0.9858 0.46487 0.22176 HLH;Myc_N;Myc-LZ binding;DNA binding;nucleic acid binding;protein binding;transcription factor activity;transcription regulator activity cell cycle arrest;cell proliferation;cellular ion homeostasis;cellular iron ion homeostasis;cellular process;positive regulation of cell proliferation;regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Acute myeloid leukemia;Bladder cancer;Chronic myeloid leukemia;Colorectal cancer;Endometrial cancer;ErbB signaling pathway;Jak-STAT signaling pathway;MAPK signaling pathway;Pathways in cancer;Small cell lung cancer;TGF-beta signaling pathway;Thyroid cancer;Wnt signaling pathway 3 3 3 4 4 4 50.564 0.0055939 19160000 12998000 6161600 2425 IPI:IPI00033016.2;IPI:IPI00935431.1 Myc proto-oncogene protein;c-Myc;Transcription factor p64 MYC P01106-2;P01106;P01106-1 ENST00000377970 K04377 2 0.77514 1.499 0.76622 1.0071 0.9839 0.99191 Dynamin_M;Dynamin_N;GED;PH cell junction;cell part;cytoplasm;cytoskeletal part;intracellular organelle part;intracellular part;membrane;membrane part;microtubule;organelle part;plasma membrane part;postsynaptic density;postsynaptic membrane;synapse part binding;catalytic activity;cytoskeletal protein binding;GTP binding;GTPase activity;hydrolase activity;microtubule binding;motor activity;nucleotide binding;protein binding;pyrophosphatase activity;transcription activator activity;tubulin binding cell communication;cellular process;endocytosis;G2/M transition of mitotic cell cycle;membrane invagination;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;signal transduction;transport 25 25 19 28.6 28.6 22.5 98.063 9.1265E-218 770730000 418010000 352720000 2426 IPI:IPI00033022.2;IPI:IPI00218889.3;IPI:IPI00413140.4;IPI:IPI00887273.1;IPI:IPI00888758.1;IPI:IPI00657691.2;IPI:IPI00816287.3 Dynamin-2 DNM2;DYN2 P50570-1;P50570;P50570-2 ENST00000355667;ENST00000359692;ENST00000389253 K01528 7 0.84609 1.6026 0.88548 1.0953 1.0371 1.1237 ARM_1 cell fraction;cytosol;insoluble fraction;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;macromolecular complex;membrane fraction;membrane-bounded organelle;nucleus;organelle;proteasome complex proteasome activator activity;proteasome regulator activity cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein complex assembly;RNA elongation;RNA elongation from RNA polymerase II promoter 4 4 4 11.3 11.3 11.3 42.153 2.5646E-48 103760000 52283000 51473000 2427 IPI:IPI00033030.2 Proteasomal ubiquitin receptor ADRM1;Adhesion-regulating molecule 1;110 kDa cell membrane glycoprotein;Rpn13 homolog;Proteasome regulatory particle non-ATPase 13 ADRM1;GP110 Q16186 ENST00000253003 1 0.74336 1.2364 0.692 0.98612 0.84569 0.89234 Peptidase_M24 cell part;cytoplasm;intracellular part aminopeptidase activity;binding;catalytic activity;cation binding;exopeptidase activity;hydrolase activity;ion binding;metal ion binding;metalloexopeptidase activity;metallopeptidase activity;peptidase activity;transition metal ion binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;peptidyl-amino acid modification;peptidyl-methionine modification;protein metabolic process;protein modification process;protein processing;proteolysis 9 9 9 23.2 23.2 23.2 52.891 2.8059E-158 198900000 106880000 92017000 2428 IPI:IPI00033036.1 Methionine aminopeptidase 2;Peptidase M 2;Initiation factor 2-associated 67 kDa glycoprotein;p67eIF2 METAP2;MNPEP;P67EIF2 P50579 ENST00000323666 K01265 1 0.56532 1.2361 NaN 0.76586 0.78756 NaN NIF catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;phosphatase activity;phosphoprotein phosphatase activity;phosphoric ester hydrolase activity 2 2 2 6.4 6.4 6.4 52.998 2.582E-08 2466700 1389200 1077500 2429 IPI:IPI00033054.5;IPI:IPI00871437.1 CTD small phosphatase-like protein 2 CTDSPL2;HSPC058;HSPC129 Q05D32-1;Q05D32;Q05D32-2 ENST00000260327;ENST00000396780 2 0.89228 1.5837 0.90053 1.1063 1.0883 1.1414 Abhydrolase_1 cell part;integral to membrane;intrinsic to membrane;membrane part 9 9 9 17.6 17.6 17.6 63.243 1.0584E-44 148400000 78310000 70093000 2430 IPI:IPI00033075.3 Protein BAT5;HLA-B-associated transcript 5;Protein G5 BAT5;G5;NG26;PP199 O95870 ENST00000293664;ENST00000375842;ENST00000383422;ENST00000395952 1 0.7981 1.5362 0.8201 1.057 1.001 1.0724 ThiF cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP-dependent protein binding;binding;catalytic activity;enzyme activator activity;enzyme regulator activity;ligase activity;protein binding;protein C-terminus binding;small protein activating enzyme activity;ubiquitin activating enzyme activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;protein modification process;protein ubiquitination;proteolysis Ubiquitin mediated proteolysis 13 13 13 46 46 46 38.449 3.9661E-211 588620000 312550000 276070000 2431 IPI:IPI00033130.3 SUMO-activating enzyme subunit 1;Ubiquitin-like 1-activating enzyme E1A SAE1;AOS1;SUA1;UBLE1A Q9UBE0 ENST00000270225 K10684 1 0.9464 1.6273 0.83474 1.1689 1.1604 1.0222 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle acid-amino acid ligase activity;binding;catalytic activity;copper ion binding;ion binding;ligase activity;ligase activity, forming carbon-nitrogen bonds;NEDD8 ligase activity;protein binding;small conjugating protein ligase activity;zinc ion binding anti-apoptosis;induction of apoptosis;induction of apoptosis by intracellular signals;metabolic process;protein modification process;proteolysis;redox signal response;response to oxidative stress;response to stress Ubiquitin mediated proteolysis 2 2 2 18.6 18.6 18.6 12.683 1.0061E-20 37566000 18371000 19195000 2432 IPI:IPI00033132.3 RING-box protein 2;RING finger protein 7;Regulator of cullins 2;CKII beta-binding protein 1;Sensitive to apoptosis gene protein RNF7;RBX2;ROC2;SAG Q9UBF6-1;Q9UBF6 ENST00000273480;ENST00000392999 K10611 1 0.78173 1.4086 0.77292 0.98716 0.97538 1.0096 SAC3_GANP cell part;cytoplasmic part;cytosol;eukaryotic translation initiation factor 3 complex;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;protein complex binding;nucleic acid binding;protein binding;ribonucleoprotein binding;ribosome binding;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity cellular process;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of translation;regulation of translational initiation;translational initiation 10 10 10 57.3 57.3 57.3 25.059 0 695360000 359720000 335640000 2433 IPI:IPI00033143.1 Eukaryotic translation initiation factor 3 subunit K;Eukaryotic translation initiation factor 3 subunit 12;eIF-3 p25;eIF-3 p28;Muscle-specific gene M9 protein;PLAC-24 EIF3K;EIF3S12;ARG134;HSPC029;MSTP001;PTD001 Q9UBQ5 ENST00000248342 1 0.67305 1.4082 0.65667 0.90037 0.908 0.85437 LRR_1;NTF2;TAP_C;Tap-RNA_bind cell part;cytoplasm;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;nucleotide binding;protein binding interspecies interaction between organisms;multi-organism process 12 12 12 22.3 22.3 22.3 70.182 1.1141E-136 112380000 57384000 54993000 2434 IPI:IPI00033153.1 Nuclear RNA export factor 1;Tip-associating protein;Tip-associated protein;mRNA export factor TAP NXF1;TAP Q9UBU9 ENST00000294172 1 0.60868 1.8581 0.70694 0.81552 1.3191 0.89473 AlaDh_PNT_C;AlaDh_PNT_N;Saccharop_dh cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle binding;catalytic activity;electron carrier activity;oxidoreductase activity;oxidoreductase activity, acting on the CH-NH group of donors;saccharopine dehydrogenase activity anatomical structure formation;cellular component assembly;cellular component organization;macromolecular complex subunit organization;metabolic process;oxidation reduction;protein complex assembly;protein oligomerization;protein tetramerization Lysine biosynthesis;Lysine degradation 2 2 2 2.7 2.7 2.7 102.13 8.164E-12 6719000 4021400 2697600 2435 IPI:IPI00033217.3 Alpha-aminoadipic semialdehyde synthase, mitochondrial;LKR/SDH;Lysine ketoglutarate reductase;Saccharopine dehydrogenase AASS Q9UDR5 ENST00000358954;ENST00000393376 K00290;K00291;K00292 1 0.50272 0.94967 0.46715 0.62772 0.66079 0.56658 WD40 endoplasmic reticulum membrane;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane;membrane-bounded organelle;nucleus;organelle;organelle membrane;organelle part binding;DNA binding;nucleic acid binding biosynthetic process;ER to Golgi vesicle-mediated transport;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription;transport 8 8 8 29.3 29.3 29.3 45.468 1.5579E-147 126180000 74004000 52179000 2436 IPI:IPI00033349.3 Prolactin regulatory element-binding protein;Mammalian guanine nucleotide exchange factor mSec12 PREB;SEC12 Q9HCU5 ENST00000260643 1 0.67611 NaN NaN 0.9034 NaN NaN HGTP_anticodon chromosome;cytoplasmic chromosome;cytoplasmic part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;mitochondrial chromosome;mitochondrial part;non-membrane-bounded organelle;organelle;organelle part aminoacyl-tRNA ligase activity;binding;catalytic activity;DNA binding;DNA-directed DNA polymerase activity;glycine-tRNA ligase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;single-stranded DNA binding DNA metabolic process;DNA repair;DNA replication;DNA-dependent DNA replication;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;tRNA aminoacylation for protein translation;tRNA metabolic process 2 2 2 4.1 4.1 4.1 54.91 2.232E-06 550970 294250 256710 2438 IPI:IPI00033486.2 DNA polymerase subunit gamma-2, mitochondrial;Mitochondrial DNA polymerase accessory subunit;PolG-beta;MtPolB;DNA polymerase gamma accessory 55 kDa subunit POLG2;MTPOLB Q9UHN1 ENST00000322670 K02333 1 0.61445 1.1565 0.67157 0.76704 0.81014 0.81633 efhand cell part;contractile fiber part;cytoplasmic part;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;muscle myosin complex;myosin complex;myosin II complex;organelle part;protein complex binding;calcium ion binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;motor activity;pyrophosphatase activity biological regulation;regulation of biological process;regulation of multicellular organismal process;regulation of muscle contraction;regulation of system process Focal adhesion;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Tight junction 11 11 11 54.7 54.7 54.7 19.779 1.0059E-208 1957300000 1052000000 905290000 2439 IPI:IPI00033494.3;IPI:IPI00220573.4;IPI:IPI00220278.5 Myosin regulatory light chain 12B;Myosin regulatory light chain MRLC2;Myosin regulatory light chain 2-B, smooth muscle isoform;MLC-2A;SHUJUN-1;Myosin regulatory light chain 20 kDa;Myosin regulatory light chain 12A;Myosin regulatory light chain MRLC3;Myosin regulatory light chain 2, nonsarcomeric;Myosin RLC;MLC-2B;Myosin regulatory light polypeptide 9;Myosin regulatory light chain 9;Myosin regulatory light chain MRLC1;Myosin regulatory light chain 2, smooth muscle isoform;MLC-2C;LC20 MYL12B;MRLC2;MYLC2B;MYL12A;MLCB;MRLC3;RLC;MYL9;MLC2;MRLC1;MYRL2 O14950;P19105;P24844 ENST00000237500;ENST00000400174;ENST00000400175;ENST00000400177;ENST00000217652;ENST00000279022 K10351 3 0.56142 1.4011 0.59692 0.7486 0.91686 0.77294 Spc97_Spc98 centriole;cytoplasmic part;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;microtubule;non-membrane-bounded organelle;organelle;organelle part;polar microtubule;spindle microtubule binding;cytoskeletal protein binding;gamma-tubulin binding;protein binding;structural constituent of cytoskeleton;structural molecule activity;tubulin binding cellular component organization;cellular process;cytoskeleton organization;microtubule cytoskeleton organization;microtubule nucleation;microtubule-based process;organelle organization 15 15 15 21.4 21.4 21.4 103.57 4.9702E-61 111190000 62646000 48545000 2440 IPI:IPI00033516.1;IPI:IPI00399300.1;IPI:IPI00221175.4 Gamma-tubulin complex component 3;Spindle pole body protein Spc98 homolog TUBGCP3;GCP3 Q96CW5-1;Q96CW5;Q96CW5-2 ENST00000261965;ENST00000375669 3 0.78582 1.5104 0.86313 1.0027 1.0012 1.0683 RRM_1 cell part;cytoplasm;intracellular organelle part;intracellular part;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding nuclear mRNA splicing, via spliceosome;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 6 6 6 24.6 24.6 24.6 34.208 4.8786E-135 523350000 279030000 244320000 2441 IPI:IPI00033561.3;IPI:IPI00479871.1;IPI:IPI00783594.3 RNA-binding protein with serine-rich domain 1;SR-related protein LDC2 RNPS1;LDC2 Q15287-1;Q15287;Q15287-2;Q15287-3 ENST00000320225;ENST00000397086 3 1.0672 1.7378 0.93044 1.3768 1.1638 1.4637 RUN cell part;cell projection;filopodium;growth cone;neuron projection;site of polarized growth negative regulation of cell development;regulation of anatomical structure morphogenesis;regulation of cell morphogenesis;regulation of cell morphogenesis involved in differentiation;regulation of neuron projection development 7 6 6 16.8 15.2 15.2 55.874 1.7141E-28 181150000 106340000 74815000 2442 IPI:IPI00908586.1;IPI:IPI00033573.4;IPI:IPI00760675.1;IPI:IPI00465048.7 Protein RUFY3;Rap2-interacting protein x;Single axon-regulated protein RUFY3;KIAA0871 Q7L099-2;Q7L099;Q7L099-1 ENST00000226328;ENST00000381006 4 0.50595 1.0506 0.49917 0.66405 0.71312 0.65828 LRR_1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;enzyme regulator activity;phosphatase regulator activity;protein binding;protein phosphatase regulator activity;protein phosphatase type 1 regulator activity 15 15 15 41.4 41.4 41.4 41.564 0 683160000 394360000 288800000 2444 IPI:IPI00033600.1;IPI:IPI00395771.1;IPI:IPI00759705.1;IPI:IPI00759816.1 Protein phosphatase 1 regulatory subunit 7;Protein phosphatase 1 regulatory subunit 22 PPP1R7;SDS22 Q15435-1;Q15435;Q15435-2;Q15435-3;Q15435-4 ENST00000234038;ENST00000272983;ENST00000407025 4 1.1622 2.584 NaN 1.5639 1.6293 NaN Pkinase cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cellular biopolymer metabolic process;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process 3 1 1 3.5 1.9 1.9 129.17 5.2171E-19 456190 322300 133880 2445 IPI:IPI00337426.1;IPI:IPI00033606.5;IPI:IPI00412057.2 BMP-2-inducible protein kinase BMP2K;BIKE;HRIHFB2017 Q9NSY1-1;Q9NSY1;Q9NSY1-3;Q9NSY1-2 ENST00000264889;ENST00000335016;ENST00000389010 K08854 3 0.45868 0.79952 0.637 0.60251 0.55886 0.77158 PC_rep cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part catabolic process;cellular process;macromolecule catabolic process;metabolic process;mitosis;nuclear division;organelle organization;proteasomal protein catabolic process;proteolysis;ubiquitin-dependent protein catabolic process Cell cycle;Cell cycle - yeast;Progesterone-mediated oocyte maturation;Ubiquitin mediated proteolysis 9 9 9 5.2 5.2 5.2 216.5 1.1027E-64 69791000 37274000 32517000 2446 IPI:IPI00033907.1 Anaphase-promoting complex subunit 1;Cyclosome subunit 1;Testis-specific gene 24 protein;Mitotic checkpoint regulator ANAPC1;TSG24 Q9H1A4 ENST00000341068 K03348 1 0.56467 1.4304 0.66018 0.80354 0.90124 0.906 BRO1;Y_phosphatase cell part;cytoplasmic part;cytoplasmic vesicle;intracellular organelle;intracellular part;organelle;vesicle catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;phosphatase activity;phosphoprotein phosphatase activity;phosphoric ester hydrolase activity;protein tyrosine phosphatase activity cellular biopolymer metabolic process;cellular process;dephosphorylation;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid dephosphorylation;protein metabolic process;protein modification process 19 19 19 16 16 16 178.97 3.288E-217 94158000 53479000 40679000 2448 IPI:IPI00034006.1 Tyrosine-protein phosphatase non-receptor type 23;His domain-containing protein tyrosine phosphatase;Protein tyrosine phosphatase TD14 PTPN23;KIAA1471 Q9H3S7 ENST00000265562 K01104 1 0.64342 1.8458 0.62576 0.92754 1.045 0.92131 RWD binding;protein binding 4 4 4 8.6 8.6 8.6 27.939 1.9775E-30 32090000 17539000 14551000 2449 IPI:IPI00034010.3 RWD domain-containing protein 1;DRG family-regulatory protein 2 RWDD1;DFRP2;CGI-24;PTD013 Q9H446 ENST00000368590 1 0.82894 1.5206 0.7848 1.0962 1.0133 1.0219 RRM_1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;ribonucleoprotein complex binding;BRE binding;mRNA binding;nucleic acid binding;nucleotide binding;RNA binding;translation factor activity, nucleic acid binding;translation regulator activity;translation repressor activity;translation repressor activity, nucleic acid binding cellular process;embryonic development;germ cell development;mRNA splice site selection;negative regulation of macromolecule metabolic process;negative regulation of metabolic process;regulation of gene expression 8 6 6 17.6 13.7 13.7 55 8.2217E-89 159060000 82428000 76635000 2450 IPI:IPI00853009.1;IPI:IPI00034015.1;IPI:IPI00218389.1;IPI:IPI00218388.1 CUG-BP- and ETR-3-like factor 1;Bruno-like protein 2;RNA-binding protein BRUNOL-2;CUG triplet repeat RNA-binding protein 1;Deadenylation factor CUG-BP;50 kDa nuclear polyadenylated RNA-binding protein;Embryo deadenylation element-binding protein homolog CUGBP1;BRUNOL2;CELF1;CUGBP;NAB50 Q92879-4;Q92879;Q92879-1;Q92879-3;Q92879-2 ENST00000310513;ENST00000358597;ENST00000361904;ENST00000395290;ENST00000395292 4 0.78525 1.5204 0.82711 1.0481 0.98023 1.0538 ResIII;UPF1_Zn_bind cell part;chromatin;chromosomal part;cytoplasm;intracellular organelle part;intracellular part;organelle part ATP-dependent RNA helicase activity;binding;catalytic activity;chromatin binding;DNA binding;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;RNA binding;RNA helicase activity DNA metabolic process;DNA repair;DNA replication;nuclear-transcribed mRNA catabolic process;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA catabolic process 37 37 37 39 39 39 124.34 0 1210200000 635220000 574970000 2451 IPI:IPI00034049.1;IPI:IPI00399170.1 Regulator of nonsense transcripts 1;ATP-dependent helicase RENT1;Nonsense mRNA reducing factor 1;Up-frameshift suppressor 1 homolog UPF1;KIAA0221;RENT1 Q92900-1;Q92900;Q92900-2 ENST00000262803 2 0.53757 1.3649 0.52458 0.72676 0.87645 0.67087 RrnaAD cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial nucleoid;mitochondrial part;nucleoid;organelle part binding;catalytic activity;methyltransferase activity;N-methyltransferase activity;protein binding;RNA methyltransferase activity;rRNA (adenine-N6,N6-)-dimethyltransferase activity;transcription cofactor activity;transcription factor binding nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;RNA methylation;rRNA modification;rRNA processing;transcription;transcription from mitochondrial promoter;transcription, DNA-dependent 5 5 5 11.4 11.4 11.4 45.348 2.0469E-23 15160000 8335300 6824600 2452 IPI:IPI00034069.1 Dimethyladenosine transferase 2, mitochondrial;S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2;Mitochondrial 12S rRNA dimethylase 2;Mitochondrial transcription factor B2;Hepatitis C virus NS5A-transactivated protein 5 TFB2M;NS5ATP5 Q9H5Q4 ENST00000366514 1 0.95026 1.7282 0.90429 1.2088 1.1528 1.1646 vATP-synt_AC39 macromolecular complex;proton-transporting two-sector ATPase complex;proton-transporting two-sector ATPase complex, proton-transporting domain;proton-transporting V-type ATPase complex;vacuolar proton-transporting V-type ATPase complex binding;protein binding ATP biosynthetic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;transport Epithelial cell signaling in Helicobacter pylori infection;Oxidative phosphorylation;Vibrio cholerae infection 10 10 10 30.8 30.8 30.8 40.329 6.3828E-93 267810000 137710000 130100000 2453 IPI:IPI00034159.1 V-type proton ATPase subunit d 1;Vacuolar proton pump subunit d 1;V-ATPase AC39 subunit;V-ATPase 40 kDa accessory protein;P39;32 kDa accessory protein ATP6V0D1;ATP6D;VPATPD P61421 ENST00000290949 K02146 1 NaN 0.90277 NaN NaN 0.62718 NaN DUF2411;DUF2435;HEAT cell part;integral to membrane;intrinsic to membrane;membrane part binding 2 2 2 2.2 2.2 2.2 120.75 8.361E-07 912330 564880 347450 2454 IPI:IPI00034201.5 Transmembrane and coiled-coil domain-containing protein 7 TMCO7;KIAA1746 Q9C0B7 ENST00000261778 1 0.69435 1.2349 0.71307 0.92142 0.84762 0.9087 E1-E2_ATPase;Hydrolase cell part;integral to membrane;intrinsic to membrane;membrane part ATP binding;binding;catalytic activity;ion transmembrane transporter activity;magnesium ion binding;nucleoside binding;nucleotide binding;primary active transmembrane transporter activity;purine nucleoside binding;transporter activity ATP biosynthetic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;transport 12 12 9 13.5 13.5 10.3 132.95 6.2239E-104 142740000 75326000 67417000 2456 IPI:IPI00034277.1;IPI:IPI00218353.3 Probable cation-transporting ATPase 13A1 ATP13A1;ATP13A;KIAA1825;CGI-152 Q9HD20-1;Q9HD20;Q9HD20-2 ENST00000357324 K01552 2 0.69282 1.4882 0.84827 1.0064 0.88626 1.0314 CutA1 cell part;membrane binding;enzyme binding;protein binding localization;macromolecule localization;protein localization;response to chemical stimulus;response to inorganic substance;response to metal ion;response to stimulus 4 4 4 30.8 30.8 30.8 20.925 2.4397E-167 148820000 75126000 73693000 2458 IPI:IPI00034319.2;IPI:IPI00554634.1;IPI:IPI00554556.1 Protein CutA;Brain acetylcholinesterase putative membrane anchor;Acetylcholinesterase-associated protein CUTA;ACHAP;C6orf82 O60888-2;O60888;O60888-1;O60888-3 ENST00000374484;ENST00000374485;ENST00000374486;ENST00000374496;ENST00000374500 K03926 3 0.79925 1.3861 0.72022 1.0554 0.95351 0.92958 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 17 17 17 11.6 11.6 11.6 202.02 5.5281E-166 109370000 59661000 49710000 2459 IPI:IPI00036742.6;IPI:IPI00789281.2;IPI:IPI00868931.1;IPI:IPI00337420.3 Protein virilizer homolog KIAA1429;MSTP054 Q69YN4-1;Q69YN4;Q69YN4-3;Q69YN4-2;Q69YN4-4 ENST00000297591 4 0.82106 1.6018 0.78846 1.0663 1.0986 1.019 Dynamin_M;Dynamin_N;GED cis-Golgi network;cytoplasmic part;cytosol;endomembrane system;endoplasmic reticulum;Golgi apparatus part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;organelle;organelle part binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity apoptotic mitochondrial changes;cell communication;cellular component organization;cellular process;membrane organization;mitochondrial membrane organization;mitochondrion organization;multicellular organismal development;organelle organization 23 23 23 40.5 40.5 40.5 81.876 0 527780000 267650000 260130000 2460 IPI:IPI00146935.4;IPI:IPI00555883.2;IPI:IPI00037283.3;IPI:IPI00942042.1;IPI:IPI00473085.3 Dynamin-1-like protein;Dynamin-like protein;Dnm1p/Vps1p-like protein;Dynamin family member proline-rich carboxyl-terminal domain less;Dynamin-related protein 1;Dynamin-like protein 4;Dynamin-like protein IV;HdynIV DNM1L;DLP1;DRP1 O00429-1;O00429;O00429-2;O00429-5;O00429-3;O00429-4 ENST00000266479;ENST00000266481;ENST00000358214;ENST00000381000 5 0.38995 1.3453 0.62968 0.50495 0.94418 0.85227 WD40 cell part;intracellular organelle part;intracellular part;macromolecular complex;mediator complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;protein binding;receptor activity;receptor binding;receptor signaling protein activity;signal transducer activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding cell communication;intracellular signaling cascade;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;signal transduction;transcription initiation;transcription initiation from RNA polymerase II promoter 5 5 5 5.9 5.9 5.9 96.792 7.9045E-19 23623000 14368000 9255300 2461 IPI:IPI00037401.4;IPI:IPI00157783.7;IPI:IPI00556603.1;IPI:IPI00063274.4;IPI:IPI00869327.1 Mediator of RNA polymerase II transcription subunit 16;Mediator complex subunit 16;Thyroid hormone receptor-associated protein complex 95 kDa component;Vitamin D3 receptor-interacting protein complex component DRIP92 MED16;DRIP92;THRAP5 Q9Y2X0-1;Q9Y2X0;Q9Y2X0-3;Q9Y2X0-2 ENST00000269814;ENST00000312090;ENST00000325464;ENST00000395808 5 0.74344 1.6135 0.74496 0.9878 1.0446 1.0083 2-Hacid_dh;2-Hacid_dh_C cell part;cytoplasm;intracellular part binding;catalytic activity;glycerate dehydrogenase activity;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;protein binding establishment of localization;excretion;metabolic process;multicellular organismal process;oxidation reduction;secretion;system process;transport Glyoxylate and dicarboxylate metabolism;Pyruvate metabolism 13 13 13 56.4 56.4 56.4 35.668 0 638380000 348330000 290050000 2462 IPI:IPI00037448.3 Glyoxylate reductase/hydroxypyruvate reductase GRHPR;GLXR;MSTP035 Q9UBQ7 ENST00000318158;ENST00000377824 K00015;K00049 1 0.77599 1.5451 0.70925 1.0526 0.97074 0.95257 Hydrolase binding;catalytic activity;cation binding;hydrolase activity;hydrolase activity, acting on ester bonds;ion binding;magnesium ion binding;phosphatase activity;phosphoglycolate phosphatase activity;phosphoric ester hydrolase activity cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;methionine metabolic process;organic acid metabolic process;sulfur amino acid biosynthetic process;sulfur amino acid metabolic process;sulfur metabolic process Methionine metabolism 6 6 6 31 31 31 28.932 1.4236E-102 131360000 70744000 60611000 2463 IPI:IPI00038378.5;IPI:IPI00795241.1 Enolase-phosphatase E1;2,3-diketo-5-methylthio-1-phosphopentane phosphatase;MASA homolog ENOPH1;MASA;MSTP145 Q9UHY7-1;Q9UHY7;Q9UHY7-2 ENST00000273920 K09880 2 0.80927 1.5326 0.74398 1.0494 1.0166 0.95328 cell part;cytoplasm;intracellular part;membrane;plasma membrane binding;nucleic acid binding;RNA binding 23 23 23 25.5 25.5 25.5 125.27 4.421E-199 449720000 238300000 211420000 2464 IPI:IPI00384265.5;IPI:IPI00472054.2;IPI:IPI00039626.3;IPI:IPI00719085.3;IPI:IPI00220935.1;IPI:IPI00394751.1;IPI:IPI00515110.1 Constitutive coactivator of PPAR-gamma-like protein 1;Oxidative stress-associated Src activator;Protein FAM120A FAM120A;C9orf10;KIAA0183;OSSA Q9NZB2-6;Q9NZB2;Q9NZB2-1;Q9NZB2-4 ENST00000277165;ENST00000340893 7 0.74644 1.4328 1.3031 0.94293 0.91645 1.7401 RanBPM_CRA;SPRY 7 5 5 19.2 12.4 12.4 67.256 3.667E-20 10381000 5582200 4799100 2465 IPI:IPI00039864.5 Ran-binding protein 10 RANBP10;KIAA1464 Q6VN20 ENST00000317506 1 0.57201 1.3255 0.99454 0.71749 0.84325 1.2593 ASF1_hist_chap cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle chromatin organization;multicellular organismal development;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;regulation of transcription, DNA-dependent;transcription 3 2 2 18.3 14.4 14.4 22.433 7.5606E-12 16837000 9385300 7452100 2466 IPI:IPI00041127.6 Histone chaperone ASF1B;Anti-silencing function protein 1 homolog B;CCG1-interacting factor A-II ASF1B Q9NVP2 ENST00000263382 K10753 1 0.56084 1.3183 0.47182 0.71245 0.80333 0.63685 Ribosomal_L7Ae Cajal body;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nuclear body;nucleolus;organelle;organelle part;ribonucleoprotein complex;small nucleolar ribonucleoprotein complex binding;nucleic acid binding;RNA binding;snoRNA binding cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;pseudouridine synthesis;RNA metabolic process;RNA modification;RNA processing;rRNA modification;rRNA processing 4 4 4 37.9 37.9 37.9 17.201 1.1789E-201 149750000 83035000 66714000 2467 IPI:IPI00041325.1 H/ACA ribonucleoprotein complex subunit 2;snoRNP protein NHP2;Nucleolar protein family A member 2 NHP2;NOLA2;HSPC286 Q9NX24 ENST00000274606 1 0.67573 1.6472 0.75131 0.92927 0.96307 0.91788 ApoO high-density lipoprotein particle;integral to membrane;intrinsic to membrane;low-density lipoprotein particle;macromolecular complex;mitochondrion;plasma lipoprotein particle;protein-lipid complex;very-low-density lipoprotein particle establishment of localization;lipid transport;transport 4 4 4 28.8 28.8 28.8 22.284 3.6957E-21 96861000 50761000 46100000 2469 IPI:IPI00042580.4;IPI:IPI00797546.2 Apolipoprotein O;Protein FAM121B APOO;FAM121B;My025;UNQ1866/PRO4302 Q9BUR5-1;Q9BUR5;Q9BUR5-2 ENST00000379220;ENST00000379226 2 0.55107 NaN NaN 0.71328 NaN NaN 2 2 2 35 35 35 17.828 9.7377E-64 14390000 7798300 6592100 2470 IPI:IPI00042604.3 Uncharacterized protein C16orf14 C16orf14 Q9BUT9-1;Q9BUT9 ENST00000307650;ENST00000397658 1 0.64742 1.3546 0.6393 0.78745 0.95209 0.88194 zf-C2H2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 2 2 2 7.1 7.1 7.1 67.832 5.2967E-06 10019000 5680900 4337900 2472 IPI:IPI00043494.6 Zinc finger protein 48;Zinc finger protein 553 ZNF48;ZNF553 Q96MX3 ENST00000320159 1 NaN NaN 0.35787 NaN NaN 0.50961 zf-C2H2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 2 2 2 1.4 1.4 1.4 247.36 3.5092E-40 4045400 2962500 1083000 2473 IPI:IPI00043516.6;IPI:IPI00869072.1;IPI:IPI00302008.2 Zinc finger protein 407 ZNF407;KIAA1703 Q9C0G0-1;Q9C0G0;Q9C0G0-2;Q9C0G0-3 ENST00000299687 3 0.65643 NaN NaN 0.86897 NaN NaN cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding cell cycle phase;cell cycle process;cell division;cellular component organization;cellular process;mitosis;nuclear division;organelle fission;organelle organization 2 2 2 6.5 6.5 6.5 41.989 0.00033209 4376900 2101500 2275400 2475 IPI:IPI00043565.3 Zinc finger protein 830;Coiled-coil domain-containing protein 16 ZNF830;CCDC16 Q96NB3 ENST00000361952 1 NaN 1.2237 0.76484 NaN 0.72949 1.0076 cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part 4 4 4 10.1 10.1 10.1 43.083 2.9977E-16 29177000 16661000 12516000 2476 IPI:IPI00043598.2;IPI:IPI00797136.2 Inhibitor of nuclear factor kappa-B kinase-interacting protein IKIP Q70UQ0-4;Q70UQ0;Q70UQ0-1 ENST00000299157;ENST00000342502;ENST00000393042 2 0.40528 0.84374 0.41048 0.52765 0.56873 0.5024 DEAD;Helicase_C cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part ATP binding;ATP-dependent helicase activity;binding;catalytic activity;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity;RNA binding 9 9 9 13.3 13.3 13.3 94.086 3.3052E-69 56361000 32530000 23830000 2477 IPI:IPI00043990.3;IPI:IPI00291296.3;IPI:IPI00552716.4;IPI:IPI00552374.1 Probable ATP-dependent RNA helicase DDX31;DEAD box protein 31;Helicain DDX31 Q9H8H2-1;Q9H8H2;Q9H8H2-2;Q9H8H2-4 ENST00000372151;ENST00000372153;ENST00000372159 4 0.38097 1.1905 0.71635 0.47843 0.71902 0.8768 catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;inositol or phosphatidylinositol phosphatase activity;phosphatase activity;phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity biological regulation;cell communication;cellular process;regulation of biological process;regulation of cellular process;signal transduction Inositol phosphate metabolism;Phosphatidylinositol signaling system 5 5 5 7.4 7.4 7.4 109.95 9.0841E-32 22209000 12758000 9450800 2479 IPI:IPI00645392.1;IPI:IPI00044388.3;IPI:IPI00916254.1;IPI:IPI00215830.1 Type I inositol-3,4-bisphosphate 4-phosphatase;Inositol polyphosphate 4-phosphatase type I INPP4A Q96PE3-1;Q96PE3;Q96PE3-3;Q96PE3-2;Q96PE3-4 ENST00000074304;ENST00000319270;ENST00000376935 K01109 4 0.69076 1.0733 0.58951 0.92629 0.73034 0.84133 PHD;ubiquitin;YDG_SRA;zf-C3HC4 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle acid-amino acid ligase activity;binding;catalytic activity;DNA binding;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleic acid binding;protein binding;ubiquitin-protein ligase activity;zinc ion binding catabolic process;cell cycle;cell proliferation;cellular process;macromolecule catabolic process;metabolic process;protein metabolic process;protein modification process;protein ubiquitination;proteolysis;ubiquitin-dependent protein catabolic process 6 5 5 10.6 9.4 9.4 89.984 4.1771E-41 17997000 9671000 8326200 2481 IPI:IPI00044681.1;IPI:IPI00395464.3 E3 ubiquitin-protein ligase UHRF2;Ubiquitin-like PHD and RING finger domain-containing protein 2;Ubiquitin-like-containing PHD and RING finger domains protein 2;Np95/ICBP90-like RING finger protein;Nuclear zinc finger protein Np97;RING finger protein 107 UHRF2;NIRF;RNF107 Q96PU4-1;Q96PU4;Q96PU4-2 ENST00000276893 2 0.55455 1.002 0.52903 0.77219 0.67321 0.70924 TruD binding;catalytic activity;intramolecular transferase activity;isomerase activity;nucleic acid binding;pseudouridine synthase activity;RNA binding cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;pseudouridine synthesis;RNA modification;RNA processing;tRNA metabolic process;tRNA modification;tRNA processing 13 13 13 21.5 21.5 21.5 75.035 2.518E-78 119130000 60215000 58910000 2483 IPI:IPI00044761.4 Pseudouridylate synthase 7 homolog PUS7;KIAA1897 Q96PZ0 ENST00000356362 K01855 1 0.5912 NaN 0.5881 0.92251 NaN 0.87766 2 2 2 7.2 7.2 7.2 38.677 0.00078001 8536200 4797100 3739100 2484 IPI:IPI00395014.1;IPI:IPI00044960.1 Arginine/serine-rich coiled-coil protein 1 RSRC1;BM-011 Q96IZ7-1;Q96IZ7;Q96IZ7-2 ENST00000295930;ENST00000312179 2 NaN 0.64296 0.60371 NaN 0.3893 0.85886 PurA cell part;chromosomal part;DNA replication factor A complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear chromosome part;nuclear part;organelle part;protein complex binding;DNA binding;mRNA binding;nucleic acid binding;protein binding;RNA binding;single-stranded DNA binding;structure-specific DNA binding;transcription factor binding biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of immune system process;transcription 6 3 3 13.1 8.3 8.3 33.24 3.4114E-22 13727000 7497400 6229200 2485 IPI:IPI00045051.3 Transcriptional activator protein Pur-beta;Purine-rich element-binding protein B PURB Q96QR8 ENST00000395699 1 0.86006 1.3826 0.95329 1.0775 0.93269 1.182 BEN;BTB cell part;cytoplasm;intracellular organelle part;intracellular part;nuclear body;nuclear part;nucleoplasm part;organelle part binding;protein binding;specific transcriptional repressor activity;transcription regulator activity;transcription repressor activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;positive regulation of cell proliferation;protein complex assembly;regulation of transcription, DNA-dependent;transcription 5 5 4 11.4 11.4 9.1 57.258 4.4558E-23 62202000 30533000 31669000 2486 IPI:IPI00045207.2 Nucleus accumbens-associated protein 1;BTB/POZ domain-containing protein 14B;Nucleus accumbens-1 NACC1;BTBD14B;NAC1 Q96RE7 ENST00000292431 K10486 1 0.37578 NaN NaN 0.4721 NaN NaN BAR_3_WASP_bdg;PX;SH3_2 cell part;endomembrane system;membrane binding;lipid binding;phosphoinositide binding;phospholipid binding;protein binding cell communication;cellular process;establishment of localization;establishment of protein localization;protein transport;transport 4 4 4 7.2 7.2 7.2 68.894 7.0141E-24 7012000 4182000 2830000 2487 IPI:IPI00045219.2;IPI:IPI00657938.1 Sorting nexin-18;Sorting nexin-associated Golgi protein 1;SH3 and PX domain-containing protein 3B SNX18;SH3PXD3B;SNAG1 Q96RF0-1;Q96RF0;Q96RF0-2 ENST00000326277 2 0.60003 3.1106 NaN 0.88339 1.8059 NaN efhand cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;endoplasmic reticulum lumen;extracellular region;Golgi apparatus;melanosome;membrane-bounded organelle;membrane-bounded vesicle;membrane-enclosed lumen;organelle;sarcoplasmic reticulum lumen;vesicle binding;calcium ion binding;cation binding;ion binding;metal ion binding 4 1 1 17.5 3.8 3.8 37.134 7.8958E-13 1730800 1108100 622670 2488 IPI:IPI00045396.1 Calumenin;Crocalbin;IEF SSP 9302 CALU O43852-2;O43852 ENST00000249364;ENST00000342367 1 NaN 1.1296 1.1785 NaN 0.78551 1.5121 PDZ cell cortex;cell junction;cell part;cell-cell junction;cytoplasmic part;endomembrane system;intracellular part;membrane part;occluding junction;plasma membrane part;tight junction binding;protein binding cell communication;cell cycle;cell surface receptor linked signal transduction;establishment or maintenance of cell polarity;G-protein coupled receptor protein signaling pathway;protein complex assembly;signal transduction Adherens junction;Chemokine signaling pathway;Neuroactive ligand-receptor interaction;Tight junction 2 2 2 1.4 1.4 1.4 151.42 0.0017189 8475000 3545500 4929500 2489 IPI:IPI00154915.1;IPI:IPI00301595.1;IPI:IPI00179063.1;IPI:IPI00163607.1;IPI:IPI00301597.2;IPI:IPI00045423.1;IPI:IPI00163608.1;IPI:IPI00165621.1;IPI:IPI00294934.2;IPI:IPI00301605.1 Partitioning defective 3 homolog;Atypical PKC isotype-specific-interacting protein;CTCL tumor antigen se2-5;PAR3-alpha PARD3;PAR3;PAR3A Q8TEW0-1;Q8TEW0;Q8TEW0-2;Q8TEW0-4;Q8TEW0-6;Q8TEW0-3;Q8TEW0-7;Q8TEW0-5;Q8TEW0-8;Q8TEW0-10;Q8TEW0-9 ENST00000340077;ENST00000346874;ENST00000350537;ENST00000374789;ENST00000374794 K04237 10 0.69097 1.6406 NaN 0.86254 1.0481 NaN MCLC cell part;cytoplasmic part;endoplasmic reticulum;Golgi apparatus;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane part;membrane-bounded organelle;nucleus;organelle 5 5 5 10 10 10 62.022 6.5666E-12 2140700 1237800 902840 2492 IPI:IPI00045511.1;IPI:IPI00396547.1;IPI:IPI00103757.1;IPI:IPI00103756.1 Chloride channel CLIC-like protein 1;Mid-1-related chloride channel protein 1 CLCC1;KIAA0761;MCLC Q96S66-1;Q96S66;Q96S66-2;Q96S66-3;Q96S66-4 ENST00000356970;ENST00000369968;ENST00000369969;ENST00000369970;ENST00000369971 4 0.89715 1.5392 0.73631 1.1889 1.0026 0.9767 Glyco_hydro_18 cell part;cytoplasmic part;extracellular region;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;lysosome;lytic vacuole;membrane-bounded organelle;organelle;vacuole binding;catalytic activity;cation binding;chitinase activity;hydrolase activity;hydrolase activity, acting on glycosyl bonds;hydrolase activity, hydrolyzing O-glycosyl compounds;ion binding aminoglycan catabolic process;aminoglycan metabolic process;carbohydrate metabolic process;chitin catabolic process;chitin metabolic process;monosaccharide metabolic process;polysaccharide catabolic process;polysaccharide metabolic process 7 7 7 20.3 20.3 20.3 47.615 1.5661E-106 75524000 39654000 35870000 2493 IPI:IPI00301185.2;IPI:IPI00940998.1;IPI:IPI00045536.2 Chitinase domain-containing protein 1;Stabilin-1-interacting chitinase-like protein CHID1;GL008;PSEC0104;SB139 Q9BWS9-2;Q9BWS9;Q9BWS9-1;Q9BWS9-3 ENST00000323541;ENST00000323578;ENST00000336845 3 0.83425 1.8025 0.80721 1.1489 1.1735 1.1258 PDZ cell junction;cytoskeleton;dendritic spine;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nucleoplasm;organelle;protein phosphatase type 1 complex;protein serine/threonine phosphatase complex actin binding;binding;cytoskeletal protein binding;enzyme inhibitor activity;phosphatase inhibitor activity;phosphatase regulator activity;phosphoprotein phosphatase inhibitor activity;protein binding;protein phosphatase 1 binding cell cycle arrest;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of cell growth;regulation of cell growth by extracellular stimulus;regulation of mitosis;RNA processing 3 3 3 5.8 5.8 5.8 89.333 7.7794E-23 41519000 21805000 19714000 2494 IPI:IPI00045550.4 Neurabin-2;Neurabin-II;Spinophilin;Protein phosphatase 1 regulatory subunit 9B PPP1R9B;PPP1R6 Q96SB3 ENST00000316878 1 0.81713 1.5495 0.57956 1.0598 0.95989 0.848 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle catalytic activity;cation transmembrane transporter activity;cytochrome-c oxidase activity;heme-copper terminal oxidase activity;ion transmembrane transporter activity;monovalent inorganic cation transmembrane transporter activity;transporter activity 5 5 5 26.9 26.9 26.9 18.094 4.7973E-21 106990000 50988000 56002000 2495 IPI:IPI00830136.1;IPI:IPI00045660.4;IPI:IPI00646750.2 Uncharacterized protein C1orf31 C1orf31 Q5JTJ3-2;Q5JTJ3;Q5JTJ3-1;Q5JTJ3-3 ENST00000366613;ENST00000366615 3 NaN 1.6669 NaN NaN 1.1574 NaN CytochromB561_N cell part;integral to membrane;intrinsic to membrane;membrane part 3 3 3 7.3 7.3 7.3 62.921 4.0746E-34 9444000 5560100 3883800 2496 IPI:IPI00045764.3;IPI:IPI00890756.1;IPI:IPI00447589.2;IPI:IPI00382802.3 Transmembrane protein 209 TMEM209 Q96SK2-1;Q96SK2;Q96SK2-2;Q96SK2-3 ENST00000336804;ENST00000397622 4 0.81426 1.4437 0.71334 1.0867 0.94824 0.90284 2OG-FeII_Oxy endoplasmic reticulum;extracellular matrix;extracellular region part;extracellular space;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle;proteinaceous extracellular matrix binding;catalytic activity;iron ion binding;oxidoreductase activity;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen metabolic process;negative regulation of biological process;negative regulation of cell proliferation;negative regulation of cellular process;regulation of biological process;regulation of cell proliferation;regulation of cellular process 10 10 10 14.7 14.7 14.7 90.615 1.2949E-78 47650000 27674000 19976000 2497 IPI:IPI00045839.3;IPI:IPI00163381.4;IPI:IPI00761114.3 Prolyl 3-hydroxylase 1;Leucine- and proline-enriched proteoglycan 1;Growth suppressor 1 LEPRE1;GROS1;P3H1;PSEC0109 Q32P28-3;Q32P28;Q32P28-1 ENST00000236040;ENST00000296388;ENST00000397054 K08134 3 0.55182 0.97101 0.62159 0.73491 0.69134 0.78944 RRM_1;SPOC cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;nucleotide binding;RNA binding cell communication;cell surface receptor linked signal transduction;metabolic process;nitrogen compound metabolic process;Notch signaling pathway;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;signal transduction;transcription 13 13 13 5.2 5.2 5.2 402.24 1.4368E-133 44981000 18543000 26439000 2498 IPI:IPI00045914.1 Msx2-interacting protein;SPEN homolog;SMART/HDAC1-associated repressor protein SPEN;KIAA0929;MINT;SHARP Q96T58 ENST00000375759 1 0.8022 1.2511 NaN 1.0622 0.85707 NaN LON cell part;cytoplasm;intracellular part;membrane ATP-dependent peptidase activity;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;peptidase activity;pyrophosphatase activity biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis 3 3 3 6.3 6.3 6.3 50.545 1.923E-11 9076600 5674900 3401800 2499 IPI:IPI00045917.3;IPI:IPI00641620.1 Protein cereblon CRBN;AD-006 Q96SW2-1;Q96SW2;Q96SW2-2 ENST00000231948 K11793 2 0.83269 1.225 NaN 1.1059 0.78161 NaN DUF1637 binding;catalytic activity;iron ion binding;oxidoreductase activity;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen metabolic process;oxidation reduction Taurine and hypotaurine metabolism 3 3 3 15.9 15.9 15.9 29.751 1.3619E-22 7603900 3997000 3606900 2500 IPI:IPI00045939.4 2-aminoethanethiol dioxygenase;Cysteamine dioxygenase ADO;C10orf22 Q96SZ5 ENST00000373783 K10712 1 0.75376 1.5153 0.67891 0.9979 0.98883 0.90663 AAA;Peptidase_M41 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;mitochondrion;organelle ATP binding;binding;catalytic activity;endopeptidase activity;metalloendopeptidase activity;metallopeptidase activity;nucleoside binding;nucleotide binding;peptidase activity;purine nucleoside binding;pyrophosphatase activity;zinc ion binding biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis 7 7 7 13.5 13.5 13.5 86.454 1.7836E-160 138100000 73014000 65090000 2501 IPI:IPI00045946.4;IPI:IPI00099529.3 ATP-dependent metalloprotease YME1L1;YME1-like protein 1;ATP-dependent metalloprotease FtsH1;Meg-4;Presenilin-associated metalloprotease YME1L1;FTSH1;YME1L;UNQ1868/PRO4304 Q96TA2-1;Q96TA2;Q96TA2-2 ENST00000326799;ENST00000376016 K08955 2 0.73548 1.5486 0.84323 0.97778 1.0425 1.1078 Cid2 4 4 4 34.7 34.7 34.7 16.62 5.3455E-98 343050000 179950000 163100000 2503 IPI:IPI00046828.4 Coiled-coil domain-containing protein 58 CCDC58 Q4VC31 ENST00000291458 1 0.68028 1.7163 0.73112 0.85612 1.1888 0.92563 Pept_tRNA_hydro aminoacyl-tRNA hydrolase activity;carboxylesterase activity;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 2 2 2 15 15 15 24.026 0.00013156 14705000 8288100 6417000 2504 IPI:IPI00048572.5 Probable peptidyl-tRNA hydrolase PTRH1;C9orf115 Q86Y79 ENST00000335223 K01056 1 0.73856 1.5323 0.75935 0.9812 0.962 1.0032 GTF2I cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;general RNA polymerase II transcription factor activity;nucleic acid binding;protein binding;RNA polymerase II transcription factor activity;transcription factor activity;transcription regulator activity cell communication;cellular process;regulation of biosynthetic process;regulation of gene expression;regulation of transcription, DNA-dependent;signal transduction;transcription initiation;transcription initiation from RNA polymerase II promoter Basal transcription factors 16 16 16 16.8 16.8 16.8 112.42 4.2037E-76 233350000 118570000 114790000 2506 IPI:IPI00054042.1;IPI:IPI00217449.1;IPI:IPI00217450.1;IPI:IPI00293242.1 General transcription factor II-I;Bruton tyrosine kinase-associated protein 135;SRF-Phox1-interacting protein;Williams-Beuren syndrome chromosomal region 6 protein GTF2I;BAP135;WBSCR6 P78347-1;P78347;P78347-3;P78347-4;P78347-2 ENST00000324896;ENST00000346152;ENST00000353920 K03121 4 0.77942 1.2183 0.55756 0.97602 0.84841 0.75158 Formyl_trans_C;Formyl_trans_N cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle catalytic activity;glycine hydroxymethyltransferase activity;methionyl-tRNA formyltransferase activity;methyltransferase activity;transferase activity;transferase activity, transferring one-carbon groups biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation Aminoacyl-tRNA biosynthesis;Methionine metabolism;One carbon pool by folate 6 6 6 18.8 18.8 18.8 43.832 1.3797E-34 24168000 6641700 17526000 2507 IPI:IPI00055753.6 Methionyl-tRNA formyltransferase, mitochondrial MTFMT;FMT;FMT1 Q96DP5 ENST00000220058 K00604 1 0.89808 1.8894 0.98322 1.2059 1.1468 1.2938 UPF0556 cell part;cytoplasmic part;ER-Golgi intermediate compartment;extracellular region;intracellular part 4 4 4 30.6 30.6 30.6 18.795 1.6377E-55 618660000 318810000 299850000 2509 IPI:IPI00056357.3 UPF0556 protein C19orf10;Stromal cell-derived growth factor SF20;Interleukin-25 C19orf10;IL25 Q969H8 ENST00000262947 1 0.65247 1.0831 0.6397 0.81742 0.7363 0.77521 V-set cell part;integral to membrane;intrinsic to membrane;membrane part binding;protein binding cell motion;cell proliferation;cellular process;developmental process;fertilization;nervous system development;reproductive process;single fertilization;skeletal muscle tissue development;striated muscle tissue development;tissue development 10 10 10 20.4 20.4 20.4 65.033 9.1881E-25 86537000 45462000 41075000 2511 IPI:IPI00056478.1;IPI:IPI00186736.3;IPI:IPI00386532.6 Immunoglobulin superfamily member 8;CD81 partner 3;Glu-Trp-Ile EWI motif-containing protein 2;Keratinocytes-associated transmembrane protein 4;LIR-D1 IGSF8;CD81P3;EWI2;KCT4 Q969P0-1;Q969P0;Q969P0-3 ENST00000314485;ENST00000358475;ENST00000368086 K06730 3 0.61765 1.1497 0.83099 0.79484 0.76678 1.0517 Ribosomal_L44 cell part;cytoplasmic part;cytosol;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome binding;protein binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 3 3 3 24.5 24.5 24.5 12.441 1.7075E-15 252840000 124610000 128230000 2512 IPI:IPI00220344.9;IPI:IPI00056494.5 60S ribosomal protein L36a;60S ribosomal protein L44;Cell migration-inducing gene 6 protein;60S ribosomal protein L36a-like RPL36A;RPL44;MIG6;RPL36AL P83881;Q969Q0 ENST00000316594;ENST00000372849;ENST00000298289 K02929 2 0.86361 1.9534 0.75851 1.2088 1.1972 1.0215 Ras cell part;cytoplasmic part;cytosol;intracellular part;membrane binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding autophagy;catabolic process;cell communication;cellular metabolic process;cellular process;intracellular signaling cascade;metabolic process;protein transport;signal transduction;small GTPase mediated signal transduction;transport 2 2 2 12.3 12.3 12.3 23.124 2.5129E-12 13685000 7802900 5882000 2513 IPI:IPI00056496.1 Ras-related protein Rab-24 RAB24 Q969Q5 ENST00000303251;ENST00000393611 K07912 1 0.96011 1.3383 0.83724 1.2274 0.93805 1.075 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding 10 10 10 27.3 27.3 27.3 54.271 2.1832E-133 226730000 113050000 113680000 2514 IPI:IPI00056499.1 Zinc finger protein 622;Zinc finger-like protein 9 ZNF622;ZPR9 Q969S3 ENST00000308683 1 NaN 1.6567 0.76731 NaN 1.0783 1.0279 zf-C2H2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 2 2 2 7.3 7.3 7.3 40.543 2.5724E-07 30995000 17270000 13725000 2516 IPI:IPI00056880.7 Zinc finger protein 787;TTF-I-interacting peptide 20 ZNF787 Q6DD87 ENST00000270459 1 0.83126 1.7275 0.68669 1.1212 1.0449 0.91809 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 4 4 4 14.9 14.9 14.9 37.013 2.9028E-112 14972000 8008900 6963300 2518 IPI:IPI00057097.3 Deoxynucleotidyltransferase terminal-interacting protein 1;Terminal deoxynucleotidyltransferase-interacting factor 1 DNTTIP1;C20orf167;TDIF1 Q9H147 ENST00000372622 K08707 1 0.76892 1.4513 0.88129 0.99138 0.96147 1.1896 O-FucT cell part;cytoplasmic part;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;organelle binding;catalytic activity;cation binding;fucosyltransferase activity;ion binding;manganese ion binding;metal ion binding;transferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring hexosyl groups alcohol metabolic process;carbohydrate metabolic process;cell communication;fucose metabolic process;monosaccharide metabolic process;protein amino acid glycosylation;protein amino acid O-linked glycosylation;protein modification process 6 6 6 20.9 20.9 20.9 43.955 6.9352E-159 73134000 37450000 35684000 2519 IPI:IPI00058192.1;IPI:IPI00218176.3 GDP-fucose protein O-fucosyltransferase 1;Peptide-O-fucosyltransferase 1 POFUT1;FUT12;KIAA0180 Q9H488-1;Q9H488;Q9H488-2 ENST00000375730;ENST00000375749 K03691 2 0.76511 1.7185 0.79231 1.1471 1.0119 1.0955 BSD Golgi apparatus;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part 6 6 6 16.8 16.8 16.8 39.933 1.6293E-82 60830000 32507000 28323000 2520 IPI:IPI00059242.3 Synapse-associated protein 1 SYAP1;PRO3113 Q96A49 ENST00000380155 1 0.88155 1.4573 0.86448 1.1077 0.96309 1.0947 Vps26 cell part;cytoplasmic part;cytosol;intracellular part;macromolecular complex;membrane part;protein complex;retromer complex binding;protein binding establishment of localization;establishment of localization in cell;establishment of protein localization;intracellular transport;protein transport;transport;vacuolar transport 9 8 8 33.3 31.2 31.2 39.154 7.7215E-173 340430000 151490000 188940000 2521 IPI:IPI00059264.3 Vacuolar protein sorting-associated protein 26B;Vesicle protein sorting 26B VPS26B Q4G0F5 ENST00000281187 1 0.82419 1.9062 0.8283 1.0791 1.2949 1.0417 Sec8_exocyst cell cortex part;cell part;cytoplasmic part;exocyst;intracellular part;macromolecular complex;protein complex binding;protein binding cellular process;establishment of localization;establishment of protein localization;membrane docking;protein transport;transport;vesicle docking;vesicle docking during exocytosis 16 16 16 19.3 19.3 19.3 110.5 3.6017E-213 81283000 43692000 37591000 2522 IPI:IPI00059279.5 Exocyst complex component 4;Exocyst complex component Sec8 EXOC4;KIAA1699;SEC8;SEC8L1 Q96A65 ENST00000253861 1 0.79373 1.6334 0.78213 1.0928 1.0042 1.0811 Mago_nashi cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;RNA binding cellular process;metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA processing;RNA splicing;transport 14 14 1 85.1 85.1 6.1 17.276 2.1363E-205 1550100000 808210000 741840000 2523 IPI:IPI00059292.3;IPI:IPI00872105.1 Protein mago nashi homolog 2 MAGOHB;MAGOH2 Q96A72 ENST00000320756 2 0.7729 1.5934 0.74901 1.0091 1.0413 0.97256 Histone;Macro Barr body;chromatin;chromosome;heterochromatin;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nuclear chromatin;nuclear heterochromatin;nucleosome;organelle;protein-DNA complex;sex chromatin;sex chromosome;X chromosome binding;DNA binding;nucleic acid binding anatomical structure formation;cellular component organization;cellular process;chromatin modification;chromatin organization;dosage compensation;nucleosome assembly;organelle organization;regulation of gene expression;regulation of metabolic process Systemic lupus erythematosus 16 16 16 50.3 50.3 50.3 39.617 0 2596400000 1405200000 1191200000 2524 IPI:IPI00304171.6;IPI:IPI00059366.4;IPI:IPI00744148.2;IPI:IPI00220994.3 Core histone macro-H2A.1;H2A.y;H2A/y;Medulloblastoma antigen MU-MB-50.205 H2AFY;MACROH2A1 O75367-1;O75367;O75367-3;O75367-2 ENST00000312469;ENST00000360597 K11251 4 0.78373 1.5551 0.86481 0.98549 1.1127 1.1217 Rft-1 cell part;integral to membrane;intrinsic to membrane;membrane part carbohydrate transmembrane transporter activity;cation transmembrane transporter activity;cation:sugar symporter activity;ion transmembrane transporter activity;lipid transporter activity;sugar:hydrogen symporter activity;transporter activity carbohydrate transport;establishment of localization;lipid transport;transport N-Glycan biosynthesis 3 3 3 4.6 4.6 4.6 60.335 7.9449E-05 37402000 20113000 17289000 2525 IPI:IPI00059368.2 Protein RFT1 homolog RFT1 Q96AA3 ENST00000296292 K06316 1 0.81917 1.6168 0.77375 1.0119 1.0861 0.96368 Abhydrolase_2 cell part;cytoplasm;intracellular part carboxylesterase activity;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;lipase activity;lysophospholipase activity;phospholipase activity 10 10 10 48.1 48.1 48.1 26.316 2.1853E-213 459960000 254790000 205170000 2527 IPI:IPI00059762.5;IPI:IPI00642838.3;IPI:REV_IPI00464954.1;IPI:REV_IPI00002277.2;IPI:REV_IPI00030829.4;IPI:REV_IPI00791856.2 Lysophospholipase-like protein 1 LYPLAL1 Q5VWZ2-1;Q5VWZ2;Q5VWZ2-2 ENST00000366928 K06999 6 0.94855 1.8801 0.96576 1.1825 1.3662 1.2449 cell part;intracellular binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding 4 4 4 32.4 32.4 32.4 20.48 8.9612E-173 84223000 42664000 41559000 2528 IPI:IPI00059764.4;IPI:IPI00877152.1 Zinc finger protein 428;Enzyme-like protein PIT13 ZNF428;C19orf37 Q96B54-1;Q96B54 ENST00000300811;ENST00000391964 2 NaN NaN 0.73091 NaN NaN 0.87528 Ank;MIB_HERC2;ZZ cell part;cytoplasmic part;endosome;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle actin binding;binding;catalytic activity;cytoskeletal protein binding;ligase activity;ligase activity, forming carbon-nitrogen bonds;protein binding;signal transducer activity;ubiquitin-protein ligase activity;zinc ion binding catabolic process;cell communication;cell surface receptor linked signal transduction;macromolecule catabolic process;metabolic process;Notch signaling pathway;protein modification process;proteolysis;regulation of signal transduction;signal transduction 2 1 1 1.7 1.1 1.1 114.39 0.0049624 30014000 15686000 14328000 2529 IPI:IPI00477349.4;IPI:IPI00383255.3;IPI:IPI00059796.6;IPI:IPI00414714.4;IPI:IPI00607637.2;IPI:IPI00386276.4;IPI:IPI00914032.1;IPI:IPI00914018.1;IPI:IPI00914066.1 E3 ubiquitin-protein ligase MIB2;Mind bomb homolog 2;Zinc finger ZZ type with ankyrin repeat domain protein 1;Skeletrophin;Novel zinc finger protein;Putative NF-kappa-B-activating protein 002N MIB2;SKD;ZZANK1 Q96AX9-1;Q96AX9;Q96AX9-3;Q96AX9-2;Q96AX9-5;Q96AX9-6;Q96AX9-4;Q96AX9-7;Q96AX9-8;Q96AX9-9 ENST00000355826;ENST00000357882;ENST00000360522;ENST00000378710 K10645 9 0.42988 1.1444 NaN 0.57971 0.69928 NaN DUF1395 cell part;chromosomal part;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;microtubule;organelle part;outer kinetochore of condensed chromosome;protein complex;spindle microtubule binding;cytoskeletal protein binding;microtubule binding;protein binding;tubulin binding cell cycle phase;cell cycle process;cellular process;chromosome segregation;mitotic anaphase;regulation of microtubule polymerization or depolymerization;regulation of microtubule-based process;regulation of organelle organization 2 2 2 7.8 7.8 7.8 29.484 2.8555E-15 7052100 4333000 2719100 2530 IPI:IPI00059912.1;IPI:IPI00645447.3 Spindle and kinetochore-associated protein 1 SKA1;C18orf24 Q96BD8-1;Q96BD8;Q96BD8-2 ENST00000285116;ENST00000398452 2 NaN 1.3596 NaN NaN 0.83716 NaN BEN;BTB cell part;intracellular organelle part;intracellular part;nuclear body;nuclear part;nucleoplasm part;organelle part binding;protein binding;specific transcriptional repressor activity;transcription regulator activity;transcription repressor activity negative regulation of biosynthetic process;negative regulation of metabolic process;positive regulation of cell proliferation;protein complex assembly;regulation of biosynthetic process;regulation of gene expression 2 1 1 6.5 4.4 4.4 62.836 1.2931E-05 931620 501690 429930 2531 IPI:IPI00059930.1 Nucleus accumbens-associated protein 2;BTB/POZ domain-containing protein 14A NACC2;BTBD14A Q96BF6 ENST00000277554;ENST00000371753 K10486 1 NaN 1.824 0.77075 NaN 1.176 1.0213 RWD;zf-C3HC4 binding;catalytic activity;cation binding;ion binding;ligase activity;metal ion binding;protein binding;transition metal ion binding;zinc ion binding catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 2 2 2 6.3 6.3 6.3 51.218 1.1828E-47 9313400 5070300 4243100 2532 IPI:IPI00059944.3 E3 ubiquitin-protein ligase RNF25;RING finger protein 25 RNF25 Q96BH1 ENST00000295704 K10640 1 NaN 2.8556 NaN NaN 1.615 NaN Arf cell part;cytoplasmic part;cytoskeletal part;endosomal part;endosome membrane;intracellular organelle part;intracellular part;late endosome membrane;lysosomal membrane;membrane;midbody;organelle membrane;organelle part;vacuolar membrane;vacuolar part binding;catalytic activity;cytoskeletal protein binding;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity;tubulin binding biological regulation;cell communication;cellular process;chromosome segregation;intracellular signaling cascade;regulation of biological process;regulation of cellular process;signal transduction;small GTPase mediated signal transduction 4 1 1 26.9 7.5 7.5 21.416 5.9782E-20 18501000 10348000 8153100 2533 IPI:IPI00060031.3 ADP-ribosylation factor-like protein 8A;ADP-ribosylation factor-like protein 10B;Novel small G protein indispensable for equal chromosome segregation 2 ARL8A;ARL10B;GIE2 Q96BM9 ENST00000272217 K07955 1 0.88809 1.3414 0.81983 1.1683 0.83909 1.0976 Coil_helix cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 4 4 4 32.2 32.2 32.2 13.475 5.5515E-23 50055000 24022000 26033000 2534 IPI:IPI00060107.3 Coiled-coil-helix-coiled-coil-helix domain-containing protein 1;C2360 CHCHD1;C10orf34 Q96BP2 ENST00000372833 1 0.93856 1.887 1.0561 1.1692 1.2087 1.4005 2 2 2 8.5 8.5 8.5 30.834 3.9793E-22 11738000 5940300 5798000 2535 IPI:IPI00060148.3 Coiled-coil domain-containing protein 127 CCDC127 Q96BQ5 ENST00000296824 1 0.82448 1.7298 0.78162 1.0813 1.1228 1.0857 efhand binding;calcium ion binding;cation binding;ion binding;metal ion binding 14 14 12 35.8 35.8 27.1 26.697 1.8446E-127 845680000 438520000 407160000 2536 IPI:IPI00060181.1 EF-hand domain-containing protein D2;Swiprosin-1 EFHD2;SWS1 Q96C19 ENST00000375980 1 0.74232 0.85081 0.79632 0.9997 0.54021 1.0846 Mmp37 cell part;cytoplasmic part;extrinsic to membrane;extrinsic to mitochondrial inner membrane;extrinsic to organelle membrane;intracellular organelle part;intracellular part;membrane part;mitochondrial membrane part;mitochondrial part;organelle part cellular process;establishment of protein localization;intracellular protein transport;mitochondrial transport;protein import;protein import into mitochondrial matrix;protein targeting;protein targeting to mitochondrion;protein transport;transport 4 4 4 16.1 16.1 16.1 35.907 7.4932E-112 54021000 29951000 24070000 2537 IPI:IPI00060287.3 MMP37-like protein, mitochondrial C3orf31 Q96BW9 ENST00000273037 1 0.16342 NaN 0.07017 0.20229 NaN 0.093235 FHA binding;protein binding 3 3 3 15.8 15.8 15.8 21.445 0.0017846 9222000 7401700 1820400 2539 IPI:IPI00060419.3 TRAF-interacting protein with FHA domain-containing protein A;TRAF2-binding protein;Putative MAPK-activating protein PM14;Putative NF-kappa-B-activating protein 20 TIFA;T2BP Q96CG3 ENST00000361717 1 0.60781 1.7115 0.80615 0.86437 1.0649 1.1076 2 2 2 22.1 22.1 22.1 14.563 0.00017458 22258000 11906000 10352000 2540 IPI:IPI00060521.1 FLYWCH family member 2 FLYWCH2 Q96CP2 ENST00000293981;ENST00000396958 1 0.76013 1.6671 0.81961 1.0838 1.1063 1.168 DUF1014 9 9 9 36.3 36.3 36.3 25.835 1.0702E-40 601390000 294890000 306500000 2542 IPI:IPI00060627.2 Coiled-coil domain-containing protein 124 CCDC124 Q96CT7 ENST00000262801 1 0.70031 1.1695 NaN 0.86837 0.75254 NaN K_tetra cation channel complex;cell part;ion channel complex;macromolecular complex;membrane part;plasma membrane part;potassium channel complex;protein complex;voltage-gated potassium channel complex binding;cation channel activity;cation transmembrane transporter activity;ion channel activity;potassium channel activity;protein binding;transporter activity;voltage-gated ion channel activity;voltage-gated potassium channel activity cation transport;establishment of localization;ion transport;metal ion transport;monovalent inorganic cation transport;potassium ion transport;transport 6 6 6 19.1 19.1 19.1 35.7 1.173E-19 17006000 8940200 8065900 2545 IPI:IPI00060715.1;IPI:IPI00002354.4 BTB/POZ domain-containing protein KCTD12;Pfetin;Predominantly fetal expressed T1 domain KCTD12;C13orf2;KIAA1778;PFET1 Q96CX2 ENST00000317765;ENST00000377474 2 0.73033 1.1907 0.10407 0.94581 0.82172 0.15355 cell part;integral to membrane;intrinsic to membrane;membrane part catalytic activity;molecular transducer activity;receptor activity;signal transducer activity;transferase activity;transferase activity, transferring alkyl or aryl (other than methyl) groups anatomical structure formation;anatomical structure formation involved in morphogenesis;angiogenesis;cell differentiation;cellular developmental process;cellular process;developmental process 2 2 2 6.5 6.5 6.5 33.224 9.2936E-18 1577400 1420800 156670 2547 IPI:IPI00061142.3 Nogo-B receptor;Nuclear undecaprenyl pyrophosphate synthase 1 homolog NUS1;C6orf68;NGBR Q96E22 ENST00000368494 1 0.8994 1.2394 NaN 1.2075 0.76757 NaN Ank 3 3 3 14.9 14.9 14.9 41.088 2.7689E-17 2668200 1294100 1374100 2548 IPI:IPI00061168.3 Ankyrin repeat domain-containing protein 40 ANKRD40 Q6AI12 ENST00000285243 1 0.64056 1.5062 0.72257 0.8755 0.95301 0.94232 Ribosomal_S10 intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;mitochondrion;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 2 2 2 13.4 13.4 13.4 22.999 8.0759E-56 52688000 29704000 22984000 2549 IPI:IPI00061245.4 28S ribosomal protein S10, mitochondrial;MRP-S10 MRPS10;MSTP040 P82664 ENST00000053468 1 0.58148 1.2888 NaN 0.69592 0.9126 NaN Myotub-related cell part;cytoplasm;intracellular part catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;phosphatase activity;phosphoric ester hydrolase activity cellular metabolic process;cellular process;dephosphorylation;metabolic process;phosphate metabolic process;phosphorus metabolic process 2 2 2 4.6 4.6 4.6 86.147 2.1611E-39 4070100 2348400 1721700 2550 IPI:IPI00061280.7;IPI:IPI00448020.1;IPI:IPI00301793.4 Myotubularin-related protein 12;Phosphatidylinositol-3 phosphate 3-phosphatase adapter subunit MTMR12;KIAA1682;PIP3AP Q9C0I1-1;Q9C0I1;Q9C0I1-2;Q9C0I1-3 ENST00000264934;ENST00000280285;ENST00000382142 3 1.1187 2.8136 1.1064 1.5551 1.763 1.5416 4 4 4 6.8 6.8 6.8 70.119 3.0819E-19 18876000 9363200 9513000 2551 IPI:IPI00061356.3;IPI:IPI00030845.4 Coiled-coil domain-containing protein 99;Rrhabdomyosarcoma antigen protein MU-RMS-40.4A;Arsenite-related gene 1 protein CCDC99 Q96EA4-1;Q96EA4;Q96EA4-2 ENST00000265295;ENST00000274631 2 0.81253 NaN NaN 1.0222 NaN NaN PAXNEB cytoplasm;DNA-directed RNA polymerase II, holoenzyme;Elongator holoenzyme complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription elongation factor complex enzyme regulator activity;kinase regulator activity;phosphorylase kinase regulator activity;protein kinase regulator activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 4 4 3 7.8 7.8 6.4 46.587 0.005157 1747000 862130 884900 2552 IPI:IPI00061376.5;IPI:IPI00784483.3 Elongator complex protein 4;PAX6 neighbor gene protein ELP4;C11orf19;PAXNEB Q96EB1-1;Q96EB1;Q96EB1-2 ENST00000265650;ENST00000350638;ENST00000379163 K11375 2 NaN NaN 1.0546 NaN NaN 1.3615 Yip1 endoplasmic reticulum;integral to membrane;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intrinsic to membrane;membrane-bounded organelle;non-membrane-bounded organelle;nucleolus;organelle 2 2 2 9.3 9.3 9.3 26.256 0.0014565 23329000 9341900 13987000 2553 IPI:IPI00061403.4 Protein YIPF6;YIP1 family member 6 YIPF6 Q96EC8 ENST00000374643 1 0.44882 0.85205 NaN 0.58616 0.61376 NaN THAP cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;identical protein binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transition metal ion binding;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 3 3 3 10.8 10.8 10.8 34.455 1.1616E-12 4063500 2350100 1713400 2555 IPI:IPI00061523.4 THAP domain-containing protein 11 THAP11;HRIHFB2206 Q96EK4 ENST00000303596 1 0.68561 1.4871 0.73808 0.93479 0.93192 0.98484 Acetyltransf_1 cell part;cytoplasmic part;endosomal part;endosome membrane;Golgi apparatus part;Golgi membrane;intracellular organelle part;intracellular part;membrane;organelle membrane;organelle part acetyltransferase activity;acyltransferase activity;catalytic activity;glucosamine 6-phosphate N-acetyltransferase activity;N-acetyltransferase activity;N-acyltransferase activity;transferase activity;transferase activity, transferring acyl groups metabolic process Aminosugars metabolism 8 8 8 58.2 58.2 58.2 20.749 1.0843E-181 95099000 51622000 43477000 2556 IPI:IPI00061525.3 Glucosamine 6-phosphate N-acetyltransferase;Phosphoglucosamine transacetylase GNPNAT1;GNA1 Q96EK6 ENST00000216410 K00621 1 0.83871 1.339 0.72059 1.1108 0.83995 0.95711 KTI12 adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding 3 3 3 9.6 9.6 9.6 38.615 5.6512E-44 25159000 13994000 11165000 2557 IPI:IPI00061528.3 Protein KTI12 homolog KTI12;SBBI81 Q96EK9 ENST00000371614 1 0.77505 1.2796 0.74351 0.97894 0.89646 0.94963 MRP_L53 intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;mitochondrion;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome 3 3 3 35.7 35.7 35.7 12.107 8.0039E-113 108730000 61403000 47328000 2558 IPI:IPI00061531.4 39S ribosomal protein L53, mitochondrial MRPL53 Q96EL3 ENST00000258105 1 0.96489 2.0706 0.98875 1.3071 1.2268 1.4229 TPR_1 binding 2 2 2 12.2 12.2 12.2 33.429 2.4276E-26 25273000 12421000 12852000 2559 IPI:IPI00061623.1 Small glutamine-rich tetratricopeptide repeat-containing protein beta;Beta-SGT;Small glutamine-rich protein with tetratricopeptide repeats 2 SGTB;SGT2 Q96EQ0 ENST00000381007 1 0.53611 1.0791 0.58296 0.72851 0.69663 0.84269 DUF1325 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 2 2 2 8.5 8.5 8.5 33.238 0.00050837 9172700 5473700 3699000 2560 IPI:IPI00061680.1 SAGA-associated factor 29 homolog;Coiled-coil domain-containing protein 101 CCDC101;SGF29 Q96ES7 ENST00000317058 1 0.76343 1.6214 0.74833 1.0171 1.0643 1.0131 DUF2052 7 7 7 26.5 26.5 26.5 38.946 2.2862E-101 123600000 66317000 57281000 2561 IPI:IPI00061777.4 Coiled-coil domain-containing protein 97 CCDC97 Q96F63 ENST00000269967 1 0.79026 1.2995 0.86901 1.006 0.88453 1.0871 C2;HECT;WW cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle acid-amino acid ligase activity;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;protein binding;small conjugating protein ligase activity;ubiquitin-protein ligase activity catabolic process;defense response;inflammatory response;macromolecule catabolic process;metabolic process;protein modification process;proteolysis;regulation of cell growth;response to stress;ubiquitin-dependent protein catabolic process Ubiquitin mediated proteolysis 7 7 5 9.2 9.2 7.2 102.8 4.0484E-37 53063000 27560000 25503000 2562 IPI:IPI00061780.1;IPI:IPI00176010.1;IPI:IPI00013009.1;IPI:IPI00328377.1;IPI:IPI00328378.1 E3 ubiquitin-protein ligase Itchy homolog;Atrophin-1-interacting protein 4;NFE2-associated polypeptide 1 ITCH Q96J02-1;Q96J02;Q96J02-2 ENST00000262650;ENST00000374864 K05632 5 0.84696 1.614 NaN 1.041 1.1467 NaN Sororin cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;chromatin binding;protein binding cell cycle process;cellular component organization;cellular process;chromosome condensation;DNA packaging;G1/S transition of mitotic cell cycle;mitotic chromosome condensation;mitotic metaphase plate congression;organelle organization 2 2 2 11.9 11.9 11.9 27.6 4.5692E-05 11603000 5631600 5971000 2563 IPI:IPI00061989.3 Sororin;Cell division cycle-associated protein 5;p35 CDCA5 Q96FF9 ENST00000275517;ENST00000404147 1 0.84659 1.7901 0.83049 1.0066 1.1394 1.0536 Dynein_light cell part;cytoplasmic part;cytoskeletal part;cytosol;dynein complex;intracellular organelle part;intracellular part;macromolecular complex;membrane;microtubule;microtubule associated complex;myosin complex;organelle part;plasma membrane;protein complex binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;microtubule motor activity;motor activity;protein binding;pyrophosphatase activity cellular process;microtubule-based process 5 5 3 39.3 39.3 14.6 10.35 2.9723E-24 398020000 204830000 193200000 2564 IPI:IPI00062037.1 Dynein light chain 2, cytoplasmic;Dynein light chain LC8-type 2 DYNLL2;DLC2 Q96FJ2 ENST00000240343 K10418 1 0.20969 2.3802 0.48703 0.30778 1.3552 0.64087 WD40 cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle 3 3 3 12.4 12.4 12.4 43.214 6.9951E-32 6575500 3534400 3041100 2565 IPI:IPI00062040.1 WD repeat-containing protein 89 WDR89;C14orf150;MSTP050 Q96FK6 ENST00000267522;ENST00000394942 1 0.77966 1.6129 0.68626 1.0459 1.0088 0.90945 HEAT centrosome;cis-Golgi network;COPI vesicle coat;ER-Golgi intermediate compartment;macromolecular complex;membrane coat;membrane-bounded organelle;microtubule organizing center;non-membrane-bounded organelle;nucleus;organelle;vesicle coat ATP binding;binding;catalytic activity;DNA binding;kinase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein tyrosine kinase activity;purine nucleoside binding;transferase activity nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;regulation of transcription, DNA-dependent;transcription 6 6 6 11.5 11.5 11.5 89.63 7.3285E-78 48863000 25427000 23436000 2566 IPI:IPI00102059.2;IPI:IPI00787009.1;IPI:IPI00186969.2;IPI:IPI00062264.4;IPI:IPI00788043.1;IPI:IPI00788089.1 N-terminal kinase-like protein;SCY1-like protein 1;Teratoma-associated tyrosine kinase;Telomerase transcriptional element-interacting factor;Telomerase regulation-associated protein SCYL1;GKLP;NTKL;TAPK;TEIF;TRAP;HT019 Q96KG9-1;Q96KG9;Q96KG9-2;Q96KG9-6;Q96KG9-4;Q96KG9-3;Q96KG9-5 ENST00000270176;ENST00000279270;ENST00000349495 K08876 6 0.67281 1.212 NaN 0.83082 0.84823 NaN DUF618 5 3 3 15.7 10.6 10.6 35.719 4.8023E-104 62380000 30195000 32185000 2567 IPI:IPI00102425.1;IPI:IPI00062336.1;IPI:IPI00385260.1 Regulation of nuclear pre-mRNA domain-containing protein 1A;Cyclin-dependent kinase inhibitor 2B-related protein;p15INK4B-related protein RPRD1A;P15RS Q96P16-1;Q96P16;Q96P16-2;Q96P16-3 ENST00000319040;ENST00000337059;ENST00000357384;ENST00000399022 3 0.65677 1.2893 0.57424 0.81948 0.84472 0.74119 tRNA-synt_1g cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-oxygen bonds;methionine-tRNA ligase activity;nucleoside binding;nucleotide binding;purine nucleoside binding cellular amino acid and derivative metabolic process;methionyl-tRNA aminoacylation;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;tRNA aminoacylation for protein translation;tRNA metabolic process Aminoacyl-tRNA biosynthesis;Methionine metabolism;Selenoamino acid metabolism 8 8 8 17.4 17.4 17.4 66.59 6.9091E-72 60847000 36081000 24766000 2569 IPI:IPI00062839.4 Methionyl-tRNA synthetase, mitochondrial;Mitochondrial methionine--tRNA ligase;Methionine--tRNA ligase 2 MARS2 Q96GW9 ENST00000282276 K01874 1 0.6322 1.2839 0.67527 0.82291 0.8785 0.87355 11 11 11 49.3 49.3 49.3 32.944 4.9042E-142 185880000 99279000 86597000 2570 IPI:IPI00062866.3;IPI:IPI00477731.2 Zinc finger CCCH-type antiviral protein 1-like ZC3HAV1L;C7orf39 Q96H79-1;Q96H79 ENST00000275766;ENST00000358573 2 0.79854 1.254 0.91751 0.99021 0.90829 1.0906 ATP_bind_3 cell part;cytoplasmic part;cytosol;intracellular part adenyl nucleotide binding;ATP binding;binding;catalytic activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;RNA binding;transferase activity;tRNA binding nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA processing;tRNA metabolic process;tRNA modification;tRNA processing;tRNA wobble base modification;tRNA wobble uridine modification 3 3 3 11.2 11.2 11.2 36.45 1.6697E-27 6032000000 2949200000 3082900000 2572 IPI:IPI00062882.4;IPI:IPI00643550.2 Cytoplasmic tRNA 2-thiolation protein 1;Cytoplasmic tRNA adenylyltransferase 1;ATP-binding domain-containing protein 3;Cancer-associated gene protein ATPBD3;CTU1;NCS6 Q7Z7A3 ENST00000270637 2 0.78553 1.7079 0.92567 0.95639 1.205 1.2157 cell part;integral to membrane;intrinsic to membrane;membrane part 4 4 4 16.9 16.9 16.9 21.198 1.1451E-65 188340000 99888000 88452000 2573 IPI:IPI00063130.2 Transmembrane protein 205 TMEM205;UNQ501/PRO1018 Q6UW68 ENST00000222124;ENST00000354882 1 0.60924 1.0035 0.59983 0.74768 0.71389 0.78683 2 2 2 17.2 17.2 17.2 13.196 0.00019719 31812000 17422000 14390000 2574 IPI:IPI00063181.4;IPI:IPI00887796.1 CDKN2AIP N-terminal-like protein;CDKN2A-interacting protein N-terminal-like protein CDKN2AIPNL Q96HQ2-1;Q96HQ2;Q96HQ2-2 ENST00000274516;ENST00000395009 2 0.73528 1.4035 NaN 0.89997 0.99526 NaN cell part;intracellular organelle part;intracellular part;macromolecular complex;mediator complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;protein binding;receptor activity;receptor binding;RNA polymerase II transcription factor activity;signal transducer activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding cell communication;cellular process;intracellular signaling cascade;regulation of biosynthetic process;regulation of transcription, DNA-dependent;signal transduction;transcription initiation;transcription initiation from RNA polymerase II promoter 2 2 2 11.8 11.8 11.8 20.277 1.6066E-29 13814000 7441800 6372500 2575 IPI:IPI00063213.1 Mediator of RNA polymerase II transcription subunit 30;Mediator complex subunit 30;Thyroid hormone receptor-associated protein 6;Thyroid hormone receptor-associated protein complex 25 kDa component;TRAP/Mediator complex component TRAP25 MED30;THRAP6;TRAP25 Q96HR3 ENST00000297347 1 NaN 2.4517 0.58739 NaN 1.5544 0.74895 SNARE_assoc cell part;integral to membrane;intrinsic to membrane;membrane part 2 2 2 6.4 6.4 6.4 29.665 0.0060873 9156600 5559700 3596900 2577 IPI:IPI00063334.3 Transmembrane protein 41A TMEM41A;UNQ168/PRO194 Q96HV5 ENST00000296254;ENST00000382227 1 0.43856 0.72258 0.35154 0.57629 0.47085 0.45132 Lactamase_B;RMMBL cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle catalytic activity;hydrolase activity 6 6 6 9.7 9.7 9.7 67.662 3.5358E-26 49951000 29016000 20935000 2578 IPI:IPI00063404.8;IPI:IPI00514973.4;IPI:IPI00306882.4 Integrator complex subunit 11;Cleavage and polyadenylation-specific factor 3-like protein;Protein related to CPSF subunits of 68 kDa CPSF3L;INTS11;RC68 Q5TA45-1;Q5TA45;Q5TA45-3;Q5TA45-2 ENST00000323275 3 NaN 1.3656 NaN NaN 0.91048 NaN PHD binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding 2 2 2 6.2 6.2 6.2 43.818 9.7673E-05 9521400 5226800 4294500 2579 IPI:IPI00063434.2;IPI:IPI00884059.1 PHD finger protein 23;PDH-containing protein JUNE-1 PHF23 Q9BUL5-1;Q9BUL5;Q9BUL5-2 ENST00000043410;ENST00000320316 2 0.8769 1.6094 NaN 1.0724 1.1346 NaN YIF1 cell part;integral to membrane;intrinsic to membrane;membrane part 3 3 3 16.6 16.6 16.6 34.435 2.1188E-110 26346000 13529000 12817000 2580 IPI:IPI00736813.1;IPI:IPI00063544.4;IPI:IPI00060144.3;IPI:IPI00869035.1;IPI:IPI00395508.2 Protein YIF1B;YIP1-interacting factor homolog B YIF1B;PP4519;UNQ3073/PRO9905 Q5BJH7-1;Q5BJH7;Q5BJH7-3;Q5BJH7-5;Q5BJH7-4 ENST00000329420;ENST00000337679;ENST00000339413;ENST00000392124;ENST00000404021 5 0.68851 NaN 0.67045 0.88253 NaN 0.90225 Isy1 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 6 6 6 19.6 19.6 19.6 37.566 5.1343E-44 99249000 51901000 47348000 2581 IPI:IPI00744858.1;IPI:IPI00063673.1;IPI:IPI00552736.1 Pre-mRNA-splicing factor ISY1 homolog ISY1;KIAA1160 Q9ULR0-1;Q9ULR0;Q9ULR0-2;Q9ULR0-3 ENST00000273541;ENST00000393295 3 0.81652 1.3601 0.85146 1.0437 0.90283 1.0453 WD40 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;RNA binding cellular process;metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA processing;RNA splicing;transport 5 5 5 16.4 16.4 16.4 41.582 1.2397E-42 252410000 125800000 126610000 2582 IPI:IPI00063729.4 THO complex subunit 3;TEX1 homolog THOC3 Q96J01 ENST00000265097 1 1.0388 2.0291 1.0209 1.2995 1.4219 1.3033 V-SNARE cell part;endomembrane system;integral to membrane;intrinsic to membrane;membrane part cell proliferation;cellular component organization;cellular process;establishment of protein localization;intracellular protein transport;membrane docking;membrane fusion;membrane organization;protein transport;transport;vesicle docking during exocytosis SNARE interactions in vesicular transport 3 3 3 15.9 15.9 15.9 26.688 1.0841E-20 73275000 36192000 37084000 2583 IPI:IPI00063784.3;IPI:IPI00386818.4 Vesicle transport through interaction with t-SNAREs homolog 1B;Vesicle transport v-SNARE protein Vti1-like 1;Vti1-rp1 VTI1B;VTI1;VTI1L;VTI1L1;VTI2 Q9UEU0-1;Q9UEU0 ENST00000216456 K08493 2 0.79795 1.3896 0.89397 1.0111 0.95473 1.1005 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle catalytic activity;hydrolase activity 6 6 6 39.5 39.5 39.5 22.345 4.0123E-69 317300000 158190000 159110000 2584 IPI:IPI00063827.1;IPI:IPI00167615.1 Abhydrolase domain-containing protein 14B;CCG1-interacting factor B ABHD14B;CIB Q96IU4-1;Q96IU4 ENST00000315851;ENST00000361143;ENST00000395008 2 0.79394 1.4554 0.77668 1.0255 0.92521 0.95139 cell part;integral to membrane;intrinsic to membrane;membrane part 3 3 3 44.8 44.8 44.8 6.4575 7.875E-92 153440000 69560000 83881000 2586 IPI:IPI00063903.5 Up-regulated during skeletal muscle growth protein 5;HCV F-transactivated protein 2 USMG5;HCVFTP2;PD04912 Q96IX5 ENST00000309579;ENST00000337003;ENST00000369811;ENST00000369815;ENST00000369825 1 1.2275 2.4221 NaN 1.5676 1.6082 NaN binding;protein binding 2 2 2 5.4 5.4 5.4 23.239 2.4741E-07 2785900 1559900 1226000 2587 IPI:IPI00063962.5 Protein DPCD DPCD Q9BVM2 ENST00000370151 1 0.66334 1.4185 NaN 0.89806 0.90752 NaN OTU cell part;cytoplasmic part;endoplasmic reticulum;Golgi apparatus part;Golgi stack;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;organelle;organelle part catalytic activity;cysteine-type peptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides;small conjugating protein-specific protease activity;ubiquitin-specific protease activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;protein modification process;protein ubiquitination;proteolysis 9 9 9 10.7 10.7 10.7 134.32 1.621E-118 20417000 13214000 7203700 2588 IPI:IPI00064162.4 Deubiquitinating protein VCIP135;Valosin-containing protein p97/p47 complex-interacting protein p135;Valosin-containing protein p97/p47 complex-interacting protein 1 VCPIP1;KIAA1850;VCIP135 Q96JH7 ENST00000310421 K11861 1 0.94615 1.9652 NaN 1.3394 1.3546 NaN Thioredoxin cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part catalytic activity;intramolecular oxidoreductase activity;intramolecular oxidoreductase activity, interconverting keto- and enol-groups;intramolecular oxidoreductase activity, transposing S-S bonds;isomerase activity;protein disulfide isomerase activity biological regulation;cell redox homeostasis;cellular homeostasis;cellular process;homeostatic process;regulation of biological process;regulation of biological quality;regulation of cellular process 4 4 4 10.1 10.1 10.1 51.871 2.5781E-16 6039400 3215100 2824300 2589 IPI:IPI00064193.3;IPI:IPI00555585.1 Protein disulfide-isomerase TMX3;Thioredoxin-related transmembrane protein 3;Thioredoxin domain-containing protein 10 TMX3;KIAA1830;TXNDC10 Q96JJ7-1;Q96JJ7;Q96JJ7-2 ENST00000299608 K09585 2 0.67935 1.3774 0.69142 0.8959 0.90474 0.86383 zf-C2H2 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding 8 8 8 11 11 11 89.098 3.1299E-26 776420000 408840000 367580000 2590 IPI:IPI00064212.2 Zinc finger protein 828 ZNF828;C13orf8;KIAA1802 Q96JM3 ENST00000361283 1 0.71814 1.4771 NaN 0.89644 0.9743 NaN BAR;RhoGAP cell junction;cell part;cell-cell junction;cytoplasm;intracellular part;membrane part;occluding junction;plasma membrane part;tight junction binding;enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity;protein binding;protein domain specific binding;SH3 domain binding biological regulation;cell communication;cellular process;regulation of biological process;regulation of cellular process;signal transduction 5 5 5 9 9 9 95.436 2.217E-17 347770000 195380000 152390000 2591 IPI:IPI00064767.3;IPI:IPI00386947.4;IPI:IPI00829657.1;IPI:IPI00830043.1;IPI:IPI00168527.2;IPI:IPI00830020.1;IPI:IPI00829687.1 Rho GTPase-activating protein 17;Rho-type GTPase-activating protein 17;RhoGAP interacting with CIP4 homologs protein 1 ARHGAP17;RICH1;MSTP066;MSTP110 Q68EM7-1;Q68EM7;Q68EM7-2;Q68EM7-5;Q68EM7-6;Q68EM7-3 ENST00000289968;ENST00000303665 7 0.58959 0.91636 0.50044 0.72016 0.64595 0.62734 Helicase_C;HSA;SNF2_N cell part;H4/H2A histone acetyltransferase complex;histone acetyltransferase complex;intracellular organelle part;intracellular part;macromolecular complex;NuA4 histone acetyltransferase complex;nuclear part;nucleoplasm part;organelle part;protein complex ATP binding;binding;catalytic activity;DNA binding;helicase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity cellular component organization;cellular process;chromatin modification;chromatin organization;covalent chromatin modification;histone modification;metabolic process;organelle organization;protein amino acid acetylation;protein modification process 8 8 8 2.9 2.9 2.9 343.61 3.7295E-37 31292000 16638000 14654000 2592 IPI:IPI00167535.6;IPI:IPI00064931.3;IPI:IPI00783692.2;IPI:IPI00798339.3 E1A-binding protein p400;p400 kDa SWI2/SNF2-related protein;Domino homolog;CAG repeat protein 32;Trinucleotide repeat-containing gene 12 protein EP400;CAGH32;KIAA1498;KIAA1818;TNRC12 Q96L91-1;Q96L91;Q96L91-2;Q96L91-3;Q96L91-4 ENST00000330386;ENST00000332482;ENST00000333577;ENST00000389561 K11320 4 0.67058 1.7005 0.85517 0.9378 1.1643 1.0992 UBX cell part;endomembrane system;membrane binding;protein binding 6 6 6 13.9 13.9 13.9 69.989 3.6839E-32 15871000 8837900 7033300 2593 IPI:IPI00065276.2;IPI:IPI00332071.4;IPI:IPI00787285.1;IPI:IPI00385430.5 Tether containing UBX domain for GLUT4;Alveolar soft part sarcoma chromosomal region candidate gene 1 protein;Alveolar soft part sarcoma locus;Renal papillary cell carcinoma protein 17;UBX domain-containing protein 9 ASPSCR1;ASPL;RCC17;TUG;UBXD9;UBXN9 Q9BZE9-2;Q9BZE9;Q9BZE9-1;Q9BZE9-3;Q9BZE9-4 ENST00000306729;ENST00000306739;ENST00000344865 4 NaN NaN 0.88434 NaN NaN 1.1066 Bromo_TP;TAF8_C cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex;transcription factor TFIID complex binding;DNA binding;nucleic acid binding;protein binding;transcription activator activity;transcription regulator activity biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 2 2 2 9.8 9.8 9.8 37.411 3.4764E-06 7512400 3747000 3765400 2594 IPI:IPI00879798.1;IPI:IPI00065313.2;IPI:IPI00878968.1 Transcription initiation factor TFIID subunit 8;TBP-associated factor 8;Transcription initiation factor TFIID 43 kDa subunit;TBP-associated factor 43 kDa;Protein taube nuss TAF8;TAFII43;TBN Q7Z7C8-4;Q7Z7C8;Q7Z7C8-2;Q7Z7C8-1 ENST00000372977;ENST00000372982 3 0.34254 1.4442 NaN 0.44767 0.95054 NaN 2 2 2 3.5 3.5 3.5 76.218 0.00087013 8843000 5112200 3730800 2595 IPI:IPI00065415.2;IPI:IPI00847886.1 Coiled-coil domain-containing protein 138 CCDC138 Q96M89-1;Q96M89;Q96M89-2 ENST00000295124 2 0.77303 1.7616 0.76494 1.2086 1.2269 1.0309 BRO1 cell part;membrane 4 4 4 13.6 13.6 13.6 46.476 1.3701E-31 26211000 14309000 11903000 2596 IPI:IPI00065500.3 BRO1 domain-containing protein BROX BROX;BROFTI;C1orf58 Q5VW32 ENST00000340934 1 0.80597 1.7417 0.59933 1.0038 1.2214 0.72518 Acyltransferase cell part;integral to membrane;intrinsic to membrane;membrane part acyltransferase activity;catalytic activity;transferase activity;transferase activity, transferring acyl groups;transferase activity, transferring acyl groups other than amino-acyl groups metabolic process 2 2 2 6.8 6.8 6.8 37.424 5.0051E-20 5006300 3059500 1946800 2597 IPI:IPI00470401.3;IPI:IPI00065510.2 Transmembrane protein 68 TMEM68 Q96MH6-1;Q96MH6;Q96MH6-2 ENST00000334667 2 0.61464 0.9854 0.55397 0.76608 0.62247 0.68954 PRK cell part;cytoplasmic part;cytosol;intracellular part ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups;uridine kinase activity metabolic process Drug metabolism - other enzymes;Pyrimidine metabolism 8 8 8 29.5 29.5 29.5 29.299 1.1853E-52 154880000 83554000 71328000 2598 IPI:IPI00065671.1;IPI:IPI00607810.1;IPI:IPI00027771.3 Uridine-cytidine kinase 2;Uridine monophosphokinase 2;Cytidine monophosphokinase 2 UCK2;TSA903;UMPK Q9BZX2-1;Q9BZX2;Q9BZX2-2 ENST00000367879 K00876 3 0.80404 2.0489 NaN 1.1197 1.2941 NaN C1_1;PH;RhoGEF;RII_binding_1 cell fraction;cell part;cytoplasm;insoluble fraction;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane fraction;membrane-bounded organelle;nucleus;organelle cAMP-dependent protein kinase activity;catalytic activity;cyclic nucleotide-dependent protein kinase activity;protein kinase activity;protein serine/threonine kinase activity;signal transducer activity;small GTPase regulator activity cell communication;cellular process;intracellular signaling cascade;regulation of cell communication;regulation of Ras protein signal transduction;regulation of Rho protein signal transduction;regulation of signal transduction;signal transduction 2 2 2 0.9 0.9 0.9 307.84 7.2765E-17 1275900 793790 482110 2599 IPI:IPI00065931.4;IPI:IPI00329783.10;IPI:IPI00829774.1;IPI:IPI00829717.1;IPI:IPI00375281.8 A-kinase anchor protein 13;Protein kinase A-anchoring protein 13;Breast cancer nuclear receptor-binding auxiliary protein;Human thyroid-anchoring protein 31;Guanine nucleotide exchange factor Lbc;AKAP-Lbc;P47;Lymphoid blast crisis oncogene;Non-oncogenic Rho GTPase-specific GTP exchange factor AKAP13;BRX;HT31;LBC Q12802-2;Q12802;Q12802-1;Q12802-4;Q12802-3;Q12802-7 ENST00000361243;ENST00000394510;ENST00000394516;ENST00000394518 5 NaN 1.9599 NaN NaN 1.2521 NaN Cyclin_N cell part;intracellular organelle part;intracellular part;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 2 2 2 7.9 7.9 7.9 58.147 3.5775E-83 576620 355660 220960 2600 IPI:IPI00066458.1;IPI:IPI00787908.2;IPI:IPI00478642.4 Cyclin-L2;Paneth cell-enhanced expression protein CCNL2;SB138 Q96S94-1;Q96S94;Q96S94-3;Q96S94-2 ENST00000400809;ENST00000400810;ENST00000408952 3 0.48643 0.93344 0.54273 0.63001 0.66391 0.68008 FAT;FATC;PI3_PI4_kinase H4/H2A histone acetyltransferase complex;histone acetyltransferase complex;macromolecular complex;NuA4 histone acetyltransferase complex;PCAF complex;protein complex;STAGA complex;transcription factor complex;transcription factor TFTC complex binding;catalytic activity;phosphotransferase activity, alcohol group as acceptor;protein binding;transcription cofactor activity;transcription factor binding;transferase activity;transferase activity, transferring phosphorus-containing groups chromatin organization;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein amino acid acetylation;protein modification process;regulation of transcription, DNA-dependent;transcription 23 23 22 7.4 7.4 7.2 437.6 4.2229E-289 789950000 223420000 566530000 2602 IPI:IPI00069084.2;IPI:IPI00879277.2 Transformation/transcription domain-associated protein;350/400 kDa PCAF-associated factor;PAF350/400;STAF40;Tra1 homolog TRRAP;PAF400 Q9Y4A5-1;Q9Y4A5;Q9Y4A5-2 ENST00000355540;ENST00000359863 K08874 2 0.55286 0.83252 0.40782 0.71732 0.56824 0.5424 LRR_1;WD40 binding;protein binding 7 7 7 13.8 13.8 13.8 79.807 4.9094E-80 88300000 50794000 37506000 2604 IPI:IPI00069309.5 Leucine-rich repeat and WD repeat-containing protein 1 LRWD1 Q9UFC0 ENST00000292616 1 NaN 1.864 0.82256 NaN 1.1803 1.205 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding 3 3 3 11.1 11.1 11.1 23.612 3.9987E-05 25168000 13022000 12146000 2605 IPI:IPI00069734.2 Zinc finger matrin-type protein 2 ZMAT2 Q96NC0 ENST00000274712 1 0.70859 1.3703 0.70853 0.94615 0.91861 0.91206 Bromodomain;PHD;WAC_Acf1_DNA_bd cell part;chromatin remodeling complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex binding;catalytic activity;chromatin binding;DNA binding;kinase activity;nucleic acid binding;protein binding;protein kinase activity;protein tyrosine kinase activity;transcription factor activity;transferase activity;zinc ion binding chromatin organization;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;regulation of transcription, DNA-dependent;transcription 21 21 21 17.6 17.6 17.6 170.9 8.8573E-152 443080000 236890000 206190000 2606 IPI:IPI00069817.2;IPI:IPI00216695.1 Tyrosine-protein kinase BAZ1B;Bromodomain adjacent to zinc finger domain protein 1B;Williams-Beuren syndrome chromosomal region 9 protein;Williams syndrome transcription factor BAZ1B;WBSC10;WBSCR10;WBSCR9;WSTF Q9UIG0-1;Q9UIG0;Q9UIG0-2 ENST00000339594;ENST00000404251 K11658 2 0.79766 1.4148 0.8088 1.0699 0.97266 1.0478 UBX CD95 death-inducing signaling complex;cell part;cytoplasmic part;cytosol;death-inducing signaling complex;intracellular part;macromolecular complex;membrane part;perinuclear region of cytoplasm;plasma membrane part;protein complex binding;enzyme binding;enzyme regulator activity;heat shock protein binding;kinase binding;kinase regulator activity;NF-kappaB binding;protein binding;protein kinase binding;protein kinase regulator activity;transcription factor binding apoptosis;catabolic process;cell death;cellular process;cytoplasmic sequestering of NF-kappaB;macromolecule catabolic process;metabolic process;proteolysis;regulation of catabolic process;ubiquitin-dependent protein catabolic process 15 15 15 19.7 19.7 19.7 73.953 3.9373E-123 407650000 208190000 199460000 2607 IPI:IPI00070643.6;IPI:IPI00219265.3 FAS-associated factor 1;UBX domain-containing protein 3A;UBX domain-containing protein 12 FAF1;UBXD12;UBXN3A;CGI-03 Q9UNN5-1;Q9UNN5;Q9UNN5-2 ENST00000345470;ENST00000396153 2 0.41548 NaN NaN 0.55411 NaN NaN PI3_PI4_kinase;PI3Ka cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;Golgi-associated vesicle;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;membrane-bounded vesicle;organelle;organelle part;vesicle 1-phosphatidylinositol 4-kinase activity;ATP binding;binding;catalytic activity;inositol or phosphatidylinositol kinase activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;transferase activity cell communication;glycerophospholipid metabolic process;lipid metabolic process;phosphate metabolic process;phosphatidylinositol biosynthetic process;phospholipid metabolic process;phosphorus metabolic process;signal transduction Inositol phosphate metabolism;Phosphatidylinositol signaling system 5 5 5 3.1 3.1 3.1 231.32 3.2735E-25 2481800 1475300 1006400 2608 IPI:IPI00070943.4;IPI:IPI00031424.1;IPI:IPI00456476.3;IPI:IPI00871913.2;IPI:IPI00885008.1 Phosphatidylinositol 4-kinase alpha PI4KA;PIK4;PIK4CA P42356-1;P42356 ENST00000255882 K00888 5 0.31487 0.7544 0.34749 0.43809 0.49644 0.43948 Pkinase cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;cyclin-dependent protein kinase activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding apoptosis;mitosis;nuclear division;organelle organization;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;regulation of cell growth;regulation of transcription, DNA-dependent 14 14 14 17.5 17.5 17.5 92.706 2.8886E-64 261280000 164810000 96475000 2609 IPI:IPI00215999.1;IPI:IPI00071185.1;IPI:IPI00376979.1;IPI:IPI00376983.1;IPI:IPI00071188.1;IPI:IPI00395687.3;IPI:IPI00099746.4;IPI:IPI00070809.2;IPI:IPI00219508.2;IPI:IPI00641338.1;IPI:IPI00334381.2;IPI:IPI00736011.3;IPI:IPI00337617.1;IPI:IPI00376980.1;IPI:IPI00759690.1;IPI:IPI00024414.1;IPI:IPI00294006.2;IPI:IPI00024413.2;IPI:IPI00015927.1 PITSLRE serine/threonine-protein kinase CDC2L1;Cell division cycle 2-like protein kinase 1;p58 CLK-1;Galactosyltransferase-associated protein kinase p58/GTA;CDK11;PITSLRE serine/threonine-protein kinase CDC2L2;Cell division cycle 2-like protein kinase 2 CDC2L1;PITSLREA;PK58;CDC2L2;CDC2L3;PITSLREB P21127-1;P21127;P21127-2;P21127-3;P21127-8;P21127-9;P21127-6;Q9UQ88-1;Q9UQ88;Q9UQ88-2;Q9UQ88-3;Q9UQ88-10;Q9UQ88-4;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-5 ENST00000340677;ENST00000341028;ENST00000341832;ENST00000356937;ENST00000378630;ENST00000378633;ENST00000407249;ENST00000317673 K08818 19 0.93443 1.3514 0.94107 1.1471 0.96099 1.1588 LUC7 binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding 11 7 7 28.8 24.3 24.3 43.727 1.2396E-123 263620000 126070000 137550000 2610 IPI:IPI00071318.1;IPI:IPI00410026.1;IPI:IPI00410027.1 Putative RNA-binding protein Luc7-like 1;SR+89;Putative SR protein LUC7B1 LUC7L;LUC7L1 Q9NQ29-1;Q9NQ29;Q9NQ29-2;Q9NQ29-3 ENST00000293872;ENST00000337351 3 NaN 1.8769 NaN NaN 1.1858 NaN CASP_C;CUT;Homeobox cell part;integral to Golgi membrane;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to Golgi membrane;intrinsic to membrane;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;RNA polymerase II transcription factor activity;sequence-specific DNA binding;transcription factor activity;transcription regulator activity negative regulation of transcription from RNA polymerase II promoter;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 2 2 2 1.5 1.5 1.5 165.69 2.1145E-05 1707800 1034400 673360 2611 IPI:IPI00419894.1;IPI:IPI00071696.2;IPI:IPI00026673.4;IPI:IPI00022370.7;IPI:IPI00472247.2;IPI:IPI00742111.1;IPI:IPI00736943.1;IPI:IPI00741668.2 Homeobox protein cut-like 1;CCAAT displacement protein;Protein CASP;Homeobox protein cut-like 2;Homeobox protein Cux-2 CUX1;CUTL1;CUX2;CUTL2;KIAA0293 P39880-3;P39880;Q13948;P39880-1;O14529;P39880-2;P39880-5;P39880-4;P39880-6 ENST00000292535;ENST00000338990;ENST00000360264;ENST00000393824;ENST00000292538;ENST00000261726 K09313 8 0.69096 1.4306 0.70242 0.93508 0.89366 0.88833 CBFD_NFYB_HMF CCAAT-binding factor complex;cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex binding;DNA binding;nucleic acid binding;protein binding;RNA polymerase II transcription factor activity;transcription coactivator activity;transcription cofactor activity;transcription factor activity;transcription factor binding nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein folding;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription Antigen processing and presentation 4 4 4 9 9 9 50.302 1.6659E-11 45354000 22440000 22914000 2612 IPI:IPI00071697.1;IPI:IPI00216407.1;IPI:IPI00911001.2 Nuclear transcription factor Y subunit gamma;Nuclear transcription factor Y subunit C;CAAT-box DNA-binding protein subunit C;Transactivator HSM-1/2 NFYC Q13952-1;Q13952;Q13952-3;Q13952-2 ENST00000308733;ENST00000372657;ENST00000372669 K08066 3 1.0832 1.7751 1.3498 1.3749 1.2055 1.6692 EFG_C;EFG_IV;GTP_EFTU;GTP_EFTU_D2 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;nucleic acid binding;nucleotide binding;pyrophosphatase activity;translation elongation factor activity;translation factor activity, nucleic acid binding biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 3 3 3 4.9 4.9 4.9 90.505 4.2861E-79 56838000 27600000 29238000 2613 IPI:IPI00071703.2;IPI:IPI00945410.1;IPI:IPI00216419.1;IPI:IPI00946969.1;IPI:IPI00172648.1 Elongation factor G 2, mitochondrial;mEF-G 2;Elongation factor G2 GFM2;EFG2;MSTP027 Q969S9-1;Q969S9;Q969S9-3;Q969S9-2;Q969S9-4;Q969S9-5 ENST00000296805;ENST00000345239 K02355 5 0.92184 3.063 0.8624 1.1653 1.9739 1.0904 cell part;cytoplasm;cytoskeletal part;intracellular organelle part;intracellular part;microtubule;organelle part apoptosis;cell cycle;cell death;cellular process;death;programmed cell death 4 4 4 6.6 6.6 6.6 76.986 1.2033E-30 46898000 25458000 21439000 2614 IPI:IPI00071824.3;IPI:IPI00946815.1;IPI:IPI00640794.4 Cytoskeleton-associated protein 2;Tumor- and microtubule-associated protein;CTCL tumor antigen se20-10 CKAP2;LB1;TMAP Q8WWK9-1;Q8WWK9;Q8WWK9-2 ENST00000258607;ENST00000378037 3 0.66001 1.5113 0.80953 0.82435 1.0788 1.0559 DUF1907 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;cation binding;hydrolase activity;hydrolase activity, acting on ester bonds;ion binding;metal ion binding;transition metal ion binding;zinc ion binding 4 4 4 15.6 15.6 15.6 35.117 8.3843E-49 19216000 10199000 9017000 2615 IPI:IPI00072044.3;IPI:IPI00761072.1;IPI:IPI00061507.2;IPI:IPI00760666.1 Ester hydrolase C11orf54 C11orf54;LP4947;PTD012 Q9H0W9-1;Q9H0W9;Q9H0W9-2;Q9H0W9-3;Q9H0W9-4 ENST00000331239;ENST00000354421 4 0.66266 1.4438 0.77647 0.88395 0.93868 1.0167 NAP cell part;cytoplasmic part;cytosol;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;nuclear part;nucleoplasm;organelle;organelle part binding;enzyme inhibitor activity;phosphatase inhibitor activity;phosphatase regulator activity;phosphoprotein phosphatase inhibitor activity;protein binding;protein phosphatase regulator activity;protein phosphatase type 2A regulator activity chromatin organization;DNA metabolic process;DNA replication;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleocytoplasmic transport;nucleosome assembly;nucleosome disassembly;transport 7 7 7 22.1 22.1 22.1 33.488 1.6852E-125 2535800000 1349500000 1186300000 2617 IPI:IPI00072377.1;IPI:IPI00301311.1 Protein SET;Phosphatase 2A inhibitor I2PP2A;Template-activating factor I;HLA-DR-associated protein II;PHAPII;Inhibitor of granzyme A-activated DNase SET Q01105-1;Q01105;Q01105-2 ENST00000372686;ENST00000372692 K11290 2 NaN 1.9305 NaN NaN 1.1901 NaN TPR_1;TPR_2 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle;perinuclear region of cytoplasm binding;protein binding anatomical structure development;cell differentiation;cellular developmental process;cellular process;developmental process;muscle organ development;organ development 25 1 1 29.1 1.5 1.5 103.08 0 583060 374950 208100 2618 IPI:IPI00072534.2;IPI:IPI00788016.1 Protein unc-45 homolog A;GCUNC-45;Smooth muscle cell-associated protein 1 UNC45A;SMAP1 Q9H3U1-1;Q9H3U1 ENST00000268159;ENST00000394275 2 0.5468 1.0438 0.63212 0.68978 0.71973 0.79726 Sec1 cell part;cytoplasmic part;endosomal part;endosome membrane;intracellular organelle part;intracellular part;late endosome membrane;lysosomal membrane;membrane;organelle membrane;organelle part;vacuolar membrane;vacuolar part cellular process;establishment of localization;establishment of protein localization;membrane docking;protein transport;transport;vesicle docking;vesicle docking during exocytosis 9 9 9 14.8 14.8 14.8 67.61 7.5945E-53 257420000 136090000 121320000 2619 IPI:IPI00073179.1 Vacuolar protein sorting-associated protein 33A VPS33A Q96AX1 ENST00000267199 1 0.71496 1.4235 0.7757 0.89907 1.0169 0.97393 Ras cell part;cytoplasmic part;cytoplasmic vesicle;ER-Golgi intermediate compartment;Golgi apparatus part;Golgi membrane;intracellular organelle;intracellular organelle part;intracellular part;membrane;organelle;organelle membrane;organelle part;vesicle binding;catalytic activity;GTP binding;GTPase activity;guanyl nucleotide binding;guanyl ribonucleotide binding;hydrolase activity;nucleotide binding;purine nucleotide binding;purine ribonucleotide binding;pyrophosphatase activity;ribonucleotide binding cell communication;cellular process;establishment of protein localization;intracellular signaling cascade;protein transport;regulation of biological process;signal transduction;small GTPase mediated signal transduction;transport 2 1 1 9.4 4.5 4.5 24.815 3.6893E-13 11891000 6392100 5499200 2620 IPI:IPI00073180.8;IPI:IPI00419932.5;IPI:IPI00302030.2 Ras-related protein Rab-37;Putative Ras-related protein Rab-12;Ras-related protein Rab-30 RAB37;RAB12;RAB30 Q96AX2;Q6IQ22;Q15771 ENST00000392613;ENST00000392614;ENST00000402449;ENST00000329286;ENST00000260056 K07914;K07907;K07917 3 0.75142 1.3359 0.67112 0.91638 0.9379 0.81562 RNase_PH cytoplasm;exosome (RNase complex);intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;protein complex 3'-5' exonuclease activity;3'-5'-exoribonuclease activity;binding;catalytic activity;exonuclease activity;exoribonuclease activity;hydrolase activity;nuclease activity;nucleic acid binding;ribonuclease activity;RNA binding cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 5 5 5 15.4 15.4 15.4 28.235 1.9416E-91 122680000 66758000 55919000 2624 IPI:IPI00073602.1 Exosome complex exonuclease MTR3;mRNA transport regulator 3 homolog;Exosome component 6;p11 EXOSC6;MTR3 Q5RKV6 ENST00000288063 1 0.83054 1.6777 0.83401 1.1179 1.0952 1.1063 RRM_1 cell part;cytoplasm;intracellular part binding;nucleic acid binding;nucleotide binding;RNA binding 3 3 3 13.1 13.1 13.1 35.196 4.8153E-120 71664000 37099000 34565000 2625 IPI:IPI00073713.3;IPI:IPI00167806.3;IPI:IPI00455161.1;IPI:IPI00001007.1 RNA-binding protein Musashi homolog 2 MSI2 Q96DH6-1;Q96DH6;Q96DH6-2;Q96DH6-3 ENST00000284073;ENST00000322684 4 0.59207 1.6668 0.68928 0.85534 0.99101 0.90622 MRP-S28 cytoplasmic part;intracellular part;macromolecular complex;mitochondrial part;mitochondrial small ribosomal subunit;organellar small ribosomal subunit;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit biosynthetic process;cellular metabolic process;cellular process;DNA damage response, detection of DNA damage;metabolic process;peptide biosynthetic process;peptide metabolic process;response to DNA damage stimulus;response to stress 6 6 6 19.5 19.5 19.5 36.844 5.1335E-26 65883000 36140000 29743000 2626 IPI:IPI00073779.1;IPI:IPI00168292.3 28S ribosomal protein S35, mitochondrial;MRP-S35;Mitochondrial ribosomal protein S28 MRPS35;MRPS28;HDCMD11P;MDS023;PSEC0213 P82673-1;P82673;P82673-2 ENST00000081029;ENST00000321446 2 0.52504 NaN 0.96114 0.70776 NaN 1.2621 cell part;chromosomal part;chromosome, centromeric region;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;nucleus;organelle;organelle part 2 2 2 9.7 9.7 9.7 31.655 2.7042E-11 128350000 60243000 68103000 2627 IPI:IPI00074020.3 Centromere protein K;Interphase centromere complex protein 37;Protein AF-5alpha;p33 CENPK;ICEN37;FKSG14 Q9BS16 ENST00000242872;ENST00000396679 K11503 1 NaN NaN 0.19729 NaN NaN 0.24756 Pkinase ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cellular biopolymer metabolic process;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process 4 3 3 6 5.1 5.1 97.318 6.1585E-14 2742400 2044600 697830 2628 IPI:IPI00074258.3;IPI:IPI00550863.2;IPI:IPI00396230.2 Microtubule-associated serine/threonine-protein kinase-like MASTL;THC2 Q96GX5-1;Q96GX5;Q96GX5-3;Q96GX5-2 ENST00000342386;ENST00000375940;ENST00000375946 K08282 3 0.74616 1.5248 0.66877 0.94607 0.99965 0.86395 FKBP12 cell part;intracellular binding;growth factor receptor binding;hepatocyte growth factor receptor binding;protein binding;receptor binding negative regulation of cell proliferation;negative regulation of immune system process;negative regulation of leukocyte activation;regulation of cytokine production;regulation of immune system process;regulation of leukocyte activation;vasculogenesis 9 9 9 15.7 15.7 15.7 68.207 1.2763E-108 88778000 47322000 41456000 2629 IPI:IPI00074604.1;IPI:IPI00218838.1 Glomulin;FKBP-associated protein;FK506-binding protein-associated protein GLMN;FAP48;FAP68;VMGLOM Q92990-1;Q92990;Q92990-2 ENST00000370360;ENST00000394498 2 0.61943 1.0521 0.7264 0.82917 0.74346 0.88162 DUF750;PUB;Transglut_core cell part;cytoplasm;intracellular part binding;catalytic activity;hydrolase activity;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity;protein binding;zinc ion binding biopolymer catabolic process;biopolymer metabolic process;catabolic process;cellular process;glycoprotein catabolic process;glycoprotein metabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process 5 5 5 9.5 9.5 9.5 74.389 5.5872E-49 10550000 6365500 4184200 2630 IPI:IPI00074605.2;IPI:IPI00165496.2;IPI:IPI00784922.1 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase;Peptide:N-glycanase;N-glycanase 1 NGLY1;PNG1 Q96IV0-1;Q96IV0;Q96IV0-2;Q96IV0-3 ENST00000280700;ENST00000308710;ENST00000396649 K01456 3 0.7458 1.5002 NaN 1.1104 0.92732 NaN zf-C2H2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 2 2 2 3.9 3.9 3.9 97.263 2.3906E-30 1819100 915560 903560 2631 IPI:IPI00074893.1 Zinc finger protein 512B ZNF512B;KIAA1196 Q96KM6 ENST00000217130;ENST00000369888 1 0.6911 NaN 0.64554 0.87916 NaN 0.79637 Ank;Oxysterol_BP cell part;intracellular binding;lipid binding;phospholipid binding alcohol metabolic process;biosynthetic process;cellular process;cholesterol metabolic process;lipid metabolic process;lipid transport;metabolic process;steroid metabolic process;sterol metabolic process;transport;vesicle-mediated transport 2 2 2 2.5 2.5 2.5 108.47 1.8277E-06 24399000 8233600 16165000 2632 IPI:IPI00075080.2;IPI:IPI00233796.2;IPI:IPI00219941.1 Oxysterol-binding protein-related protein 1 OSBPL1A;ORP1;OSBP8;OSBPL1;OSBPL1B Q9BXW6-1;Q9BXW6;Q9BXW6-3;Q9BXW6-2 ENST00000319481;ENST00000357041;ENST00000399443 3 0.33717 0.66417 0.35317 0.45542 0.44079 0.45922 cell part;chromosome;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle binding;protein binding cell cycle;DNA metabolic process;DNA repair;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to DNA damage stimulus;response to radiation;response to stress 6 6 6 4 4 4 166.46 1.1278E-56 31906000 20001000 11906000 2633 IPI:IPI00075081.1;IPI:IPI00604399.1;IPI:IPI00604576.1;IPI:IPI00604753.1 Fanconi anemia group D2 protein FANCD2;FACD Q9BXW9-1;Q9BXW9;Q9BXW9-2;Q9BXW9-3 ENST00000287647;ENST00000383806;ENST00000383807 K10891 4 0.79673 1.6373 0.82723 1.0639 1.0855 1.1431 efhand centrosome;cytosol;intracellular non-membrane-bounded organelle;intracellular organelle;membrane;microtubule;microtubule organizing center;non-membrane-bounded organelle;organelle;organelle part;plasma membrane;spindle microtubule;spindle pole binding;calcium ion binding;cation binding;cytoskeletal protein binding;ion binding;metal ion binding;N-terminal myristoylation domain binding;protein binding;protein domain specific binding;protein N-terminus binding;titin binding cell communication;cell surface receptor linked signal transduction;cellular process;G-protein coupled receptor protein signaling pathway;response to inorganic substance;response to metal ion;signal transduction Alzheimer's disease;Calcium signaling pathway;Glioma;GnRH signaling pathway;Insulin signaling pathway;Long-term potentiation;Melanogenesis;Olfactory transduction;Phosphatidylinositol signaling system;Vascular smooth muscle contraction 8 8 7 40.9 40.9 40.9 16.837 3.7682E-145 2334400000 1243600000 1090700000 2634 IPI:IPI00075248.11 Calmodulin CALM1;CALM;CAM;CAM1;CALM2;CAM2;CAMB;CALM3;CALML2;CAM3;CAMC;CAMIII P62158 ENST00000272298;ENST00000291295;ENST00000356978;ENST00000391918;ENST00000409563 K02183 1 NaN 1.3893 0.74004 NaN 0.96456 1.0175 AIG1 cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial membrane;mitochondrial outer membrane;mitochondrial part;organelle membrane;organelle outer membrane;organelle part;outer membrane binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding 2 2 2 8.1 8.1 8.1 39.584 4.2264E-05 4181500 2116100 2065400 2635 IPI:IPI00075561.1;IPI:IPI00940072.1 GTPase IMAP family member 5;Immunity-associated nucleotide 4-like 1 protein;Immunity-associated protein 3;IAN-5 GIMAP5;IAN4L1;IMAP3 Q96F15-2;Q96F15;Q96F15-1 ENST00000358647 2 0.82594 1.3028 0.60245 1.0336 0.89395 0.9575 cell part;cytoplasm;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;catalytic activity;damaged DNA binding;DNA binding;iron ion binding;nucleic acid binding;oxidoreductase activity;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen cellular process;cellular response to stress;DNA metabolic process;DNA repair;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to DNA damage stimulus;response to stress 4 4 4 20.6 20.6 20.6 33.374 6.4796E-42 4199800 2246500 1953200 2636 IPI:IPI00076597.3 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3;Alkylated DNA repair protein alkB homolog 3;Prostate cancer antigen 1;DEPC-1 ALKBH3;ABH3;DEPC1 Q96Q83-1;Q96Q83 ENST00000302708;ENST00000378840 K10860 1 1.0672 1.4999 0.90608 1.3948 0.97133 1.1528 Oxysterol_BP;PH biosynthetic process;cellular biosynthetic process;cellular lipid metabolic process;cellular metabolic process;cellular process;lipid metabolic process;lipid transport;metabolic process;primary metabolic process;steroid metabolic process;transport 7 7 7 12.8 12.8 12.8 83.785 3.6316E-14 65259000 30288000 34971000 2637 IPI:IPI00218449.4;IPI:IPI00077853.5;IPI:IPI00843808.1;IPI:IPI00746470.2;IPI:IPI00478893.2 Oxysterol-binding protein-related protein 9 OSBPL9;ORP9;OSBP4 Q96SU4-2;Q96SU4;Q96SU4-1;Q96SU4-3;Q96SU4-4;Q96SU4-5 ENST00000337809;ENST00000371710 5 0.74593 1.4955 0.5941 0.96125 1.0197 0.79044 Y_phosphatase cell part;cytoplasm;intracellular part binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;phosphatase activity;phosphoprotein phosphatase activity;phosphoric ester hydrolase activity;protein binding;protein tyrosine phosphatase activity cellular biopolymer metabolic process;cellular process;dephosphorylation;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid dephosphorylation;protein metabolic process;protein modification process MAPK signaling pathway 8 8 8 24.1 24.1 24.1 45.002 1.1353E-140 101600000 56377000 45227000 2638 IPI:IPI00081833.1;IPI:IPI00946771.1 Tyrosine-protein phosphatase non-receptor type 7;Protein-tyrosine phosphatase LC-PTP;Hematopoietic protein-tyrosine phosphatase PTPN7 P35236-2;P35236;P35236-1 ENST00000308986;ENST00000309017;ENST00000367279 K04458 2 0.73082 1.4261 0.67921 1.0003 0.87423 0.95271 BAT2_N 20 20 20 9.8 9.8 9.8 317.2 3.8354E-156 243640000 129360000 114290000 2640 IPI:IPI00083708.3;IPI:IPI00902898.1;IPI:IPI00852708.4;IPI:IPI00902809.1;IPI:IPI00148247.4;IPI:IPI00941970.1;IPI:IPI00902970.1 BAT2 domain-containing protein 1;HBxAg transactivated protein 2 BAT2D1;KIAA1096;XTP2 Q9Y520-7;Q9Y520;Q9Y520-1;Q9Y520-4;Q9Y520-5;Q9Y520-6;Q9Y520-3;Q9Y520-2 ENST00000392080 7 0.81485 1.4975 0.73098 1.0513 1.0164 1.0126 TGS intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;mitochondrial ribosome;non-membrane-bounded organelle;organellar ribosome;organelle;organelle part;ribonucleoprotein complex;ribosome binding;nucleotide binding 9 9 9 28.3 28.3 28.3 40.468 1.9532E-84 317700000 166200000 151500000 2641 IPI:IPI00084571.4;IPI:IPI00295427.4 39S ribosomal protein L39, mitochondrial;39S ribosomal protein L5, mitochondrial MRPL39;C21orf92;MRPL5;RPML5;MSTP003;PRED22 Q9NYK5-2;Q9NYK5;Q9NYK5-1 ENST00000307301;ENST00000352957 2 0.76977 1.2147 0.869 1.0149 0.84336 1.2053 Sec1 cell part;membrane cellular process;establishment of localization;establishment of protein localization;membrane docking;protein transport;transport;vesicle docking;vesicle docking during exocytosis 13 13 13 32.8 32.8 32.8 67.568 3.3427E-173 188810000 100560000 88248000 2642 IPI:IPI00084828.1;IPI:IPI00046057.1 Syntaxin-binding protein 1;Unc-18 homolog;Unc-18-1;Unc-18A;N-Sec1;p67 STXBP1;UNC18A P61764-1;P61764;P61764-2 ENST00000373299;ENST00000373302 2 0.56194 0.72783 0.56474 0.68913 0.51505 0.69585 Exonuc_X-T cell part;envelope;intracellular organelle part;intracellular part;nuclear envelope;nuclear part;organelle envelope;organelle part binding;catalytic activity;deoxyribonuclease activity;DNA binding;exodeoxyribonuclease activity;exonuclease activity;magnesium ion binding;nuclease activity;nucleic acid binding;protein binding;single-stranded DNA binding DNA metabolic process;DNA recombination;DNA repair;metabolic process;mismatch repair;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to DNA damage stimulus;response to stress 3 3 3 11.7 11.7 11.7 38.923 1.1918E-15 13608000 5121200 8486700 2643 IPI:IPI00220019.1;IPI:IPI00085084.1;IPI:IPI00411455.1 Three prime repair exonuclease 1;3'-5' exonuclease TREX1;DNase III TREX1 Q9NSU2-1;Q9NSU2;Q9NSU2-3;Q9NSU2-2 ENST00000296443;ENST00000395677 K10790 3 0.66879 1.3595 0.77285 0.88698 0.93903 0.97138 Sec1 cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;endosome membrane;Golgi membrane;Golgi-associated vesicle;lysosome;lytic vacuole;membrane;membrane-bounded organelle;membrane-bounded vesicle;organelle;organelle membrane;vacuole;vesicle cellular process;defense response;inflammatory response;intracellular protein transport;membrane docking;protein transport;response to external stimulus;response to stress;response to wounding;transport;vesicle docking during exocytosis 8 8 8 15.4 15.4 15.4 65.076 1.052E-55 21946000 11709000 10237000 2644 IPI:IPI00090327.1 Vacuolar protein sorting-associated protein 45 VPS45;VPS45A;VPS45B Q9NRW7 ENST00000369130 1 0.85778 1.5197 0.85128 1.1198 0.96823 1.0899 Amidase ATP binding;binding;carbon-nitrogen ligase activity, with glutamine as amido-N-donor;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleoside binding;nucleotide binding;purine nucleoside binding biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 6 6 6 13.1 13.1 13.1 57.46 8.6636E-43 262320000 135600000 126720000 2645 IPI:IPI00090720.4;IPI:IPI00386916.2 Glutamyl-tRNA(Gln) amidotransferase subunit A homolog;Glutaminyl-tRNA synthase-like protein 1 QRSL1 Q9H0R6-1;Q9H0R6;Q9H0R6-2 ENST00000369046 2 0.89884 1.7858 0.95996 1.1962 1.195 1.2205 Coprogen_oxidas cell part;cytoplasmic part;intracellular organelle part;intracellular part;membrane-enclosed lumen;mitochondrial intermembrane space;mitochondrial part;organelle envelope lumen;organelle part catalytic activity;coproporphyrinogen oxidase activity;oxidoreductase activity;oxidoreductase activity, acting on the CH-CH group of donors;oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor biosynthetic process;cellular process;heme biosynthetic process;heterocycle biosynthetic process;metabolic process;nitrogen compound metabolic process;porphyrin biosynthetic process;porphyrin metabolic process;tetrapyrrole metabolic process Porphyrin and chlorophyll metabolism 13 13 13 37.7 37.7 37.7 50.151 1.7968E-130 314450000 162420000 152040000 2646 IPI:IPI00093057.6 Coproporphyrinogen-III oxidase, mitochondrial CPOX;CPO;CPX P36551 ENST00000264193 K00228 1 0.9216 1.7591 0.96823 1.1284 1.1924 1.2052 PUB;zf-RanBP cell part;intracellular binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding 5 5 5 6.8 6.8 6.8 119.65 7.245E-92 11831000 6306000 5525000 2647 IPI:IPI00094740.1;IPI:IPI00409629.5;IPI:IPI00604409.1 RING finger protein 31;Zinc in-between-RING-finger ubiquitin-associated domain protein RNF31;ZIBRA Q96EP0-1;Q96EP0;Q96EP0-2 ENST00000324103;ENST00000382682;ENST00000382687 K11974 3 0.88143 1.7172 0.85027 1.1752 1.1232 1.1138 ATP-grasp_2;Ligase_CoA cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part ATP binding;binding;catalytic activity;CoA-ligase activity;GTP binding;ligase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;succinate-CoA ligase (GDP-forming) activity;succinate-CoA ligase activity acetyl-CoA metabolic process;catabolic process;cellular catabolic process;cellular metabolic process;cellular process;coenzyme catabolic process;coenzyme metabolic process;metabolic process;succinyl-CoA metabolic process;tricarboxylic acid cycle Citrate cycle (TCA cycle);Propanoate metabolism 15 15 15 35.4 35.4 35.4 46.51 8.2201E-180 503550000 268740000 234810000 2648 IPI:IPI00096066.2 Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial;GTP-specific succinyl-CoA synthetase subunit beta;Succinyl-CoA synthetase beta-G chain SUCLG2 Q96I99 ENST00000307227 K01900 1 0.81162 1.5156 1.0416 0.97184 1.062 1.2455 Ank;Pre-SET;SET cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;lysine N-methyltransferase activity;methyltransferase activity;N-methyltransferase activity;protein binding;protein methyltransferase activity;S-adenosylmethionine-dependent methyltransferase activity;zinc ion binding cellular component organization;cellular process;chromatin modification;chromatin organization;chromosome organization;organelle organization Lysine degradation 2 2 2 2.4 2.4 2.4 132.37 3.6913E-14 124100000 63531000 60568000 2649 IPI:IPI00096972.5;IPI:IPI00220795.4 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3;Histone H3-K9 methyltransferase 3;H3-K9-HMTase 3;Euchromatic histone-lysine N-methyltransferase 2;HLA-B-associated transcript 8;Protein G9a;Lysine N-methyltransferase 1C EHMT2;BAT8;C6orf30;G9A;KMT1C;NG36 Q96KQ7-1;Q96KQ7;Q96KQ7-2 ENST00000259865;ENST00000375530;ENST00000375537;ENST00000383373;ENST00000395728;ENST00000399895;ENST00000400006 K11420 2 1.6591 2.6055 NaN 2.3717 1.5928 NaN Shugoshin_C;Shugoshin_N cell part;chromosomal part;cohesin complex;intracellular organelle part;intracellular part;macromolecular complex;mitotic cohesin complex;organelle part;protein complex binding;protein binding cell cycle phase;cell cycle process;cell division;cellular component organization;cellular process;chromosome segregation;meiotic chromosome segregation;mitosis;nuclear division;organelle fission;organelle organization 2 2 2 5.9 5.9 5.9 64.189 1.6121E-54 2173100 1246800 926240 2650 IPI:IPI00554824.1;IPI:IPI00097163.4;IPI:IPI00554467.1;IPI:IPI00103154.1;IPI:IPI00554450.1;IPI:IPI00554496.1;IPI:IPI00555687.1 Shugoshin-like 1;Serologically defined breast cancer antigen NY-BR-85 SGOL1;SGO1 Q5FBB7-1;Q5FBB7;Q5FBB7-6;Q5FBB7-2;Q5FBB7-3;Q5FBB7-4;Q5FBB7-5;Q5FBB7-7 ENST00000263753;ENST00000306698;ENST00000383774 K11580 7 0.83051 2.0025 0.78542 1.094 1.2568 1.1126 zf-C2H2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 10 10 10 23.8 23.8 23.8 64.681 1.9877E-163 535910000 416310000 119600000 2651 IPI:IPI00097492.4 Zinc finger protein 512 ZNF512;KIAA1805 Q96ME7 ENST00000355467 1 NaN 1.4999 NaN NaN 0.96746 NaN F5_F8_type_C biological adhesion;cell adhesion;cellular process;response to stimulus;response to stress 3 3 3 36.1 36.1 36.1 16.297 1.6684E-33 16387000 9470600 6916100 2652 IPI:IPI00098827.1 Heat shock protein beta-11;Placental protein 25 HSPB11;C1orf41;HSPC034 Q9Y547 ENST00000194214;ENST00000371378 1 0.66822 1.3631 0.74936 0.87888 0.90569 0.94101 E1_dh;Transket_pyr cell part;cytoplasmic part;intracellular organelle part;intracellular part;membrane;mitochondrial matrix;mitochondrial membrane;mitochondrial part;organelle membrane;organelle part binding;catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor;oxoglutarate dehydrogenase (succinyl-transferring) activity alcohol metabolic process;carbohydrate metabolic process;catabolic process;cellular process;generation of precursor metabolites and energy;glucose catabolic process;glucose metabolic process;glycolysis;metabolic process;monosaccharide metabolic process Citrate cycle (TCA cycle);Lysine degradation;Tryptophan metabolism 22 22 22 27.4 27.4 27.4 115.93 0 386640000 210240000 176400000 2653 IPI:IPI00098902.4;IPI:IPI00643720.3 2-oxoglutarate dehydrogenase E1 component, mitochondrial;Alpha-ketoglutarate dehydrogenase OGDH Q02218 ENST00000222673 K00164 2 0.78004 1.4438 0.058681 1.0524 0.94048 0.077721 TPR_1;zf-CCCH cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transition metal ion binding;zinc ion binding interspecies interaction between organisms;multi-organism process 6 5 5 7.7 6 6 111.58 1.2922E-18 8454800 5822400 2632400 2655 IPI:IPI00099131.1;IPI:IPI00216361.1 Zinc finger CCCH domain-containing protein 7B;Rotavirus 'X'-associated non-structural protein ZC3H7B;KIAA1031 Q9UGR2-1;Q9UGR2;Q9UGR2-2 ENST00000351589;ENST00000352645 2 0.47542 0.92306 0.47897 0.64445 0.65432 0.60902 Gcd10p cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;protein binding;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of translation;regulation of translational initiation;RNA processing;translational initiation;tRNA metabolic process;tRNA processing 14 14 14 33.8 33.8 33.8 55.799 4.1629E-243 357070000 194740000 162330000 2656 IPI:IPI00099311.3;IPI:IPI00155747.4;IPI:IPI00885131.1 tRNA (adenine-N(1)-)-methyltransferase non-catalytic subunit TRM6;tRNA(m1A58)-methyltransferase subunit TRM6 TRMT6;KIAA1153;TRM6;CGI-09 Q9UJA5-1;Q9UJA5;Q9UJA5-2;Q9UJA5-3 ENST00000203001 K03256 3 0.81021 NaN NaN 1.0273 NaN NaN MOZ_SAS;PHD cell part;chromosomal part;histone acetyltransferase complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;nucleosome;organelle part;protein complex;protein-DNA complex binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transcription activator activity;transcription factor binding;transcription regulator activity;transcription repressor activity;zinc ion binding chromatin organization;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleosome assembly;protein amino acid acetylation;protein modification process;regulation of transcription, DNA-dependent;transcription 3 2 2 1.7 1.2 1.2 231.38 4.5639E-10 19733000 10672000 9060900 2657 IPI:IPI00099433.7;IPI:IPI00384388.4;IPI:IPI00607795.4 Histone acetyltransferase MYST4;MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4;Histone acetyltransferase MOZ2;Monocytic leukemia zinc finger protein-related factor;Histone acetyltransferase MORF MYST4;KIAA0383;MORF;MOZ2 Q8WYB5-1;Q8WYB5;Q8WYB5-2;Q8WYB5-3 ENST00000287239 K11306 3 0.59106 1.0868 0.43398 0.78344 0.7093 0.63371 Pyridoxal_deC integral to endoplasmic reticulum membrane;integral to membrane;integral to organelle membrane;intracellular part;intrinsic to endoplasmic reticulum membrane;intrinsic to membrane;intrinsic to organelle membrane;membrane part;organelle part aldehyde-lyase activity;binding;carbon-carbon lyase activity;carboxy-lyase activity;catalytic activity;cofactor binding;lipid binding;lyase activity;pyridoxal phosphate binding;sphinganine-1-phosphate aldolase activity;steroid binding;vitamin binding apoptosis;catabolic process;cell death;cellular process;ceramide metabolic process;lipid metabolic process;membrane lipid metabolic process;metabolic process;organic acid metabolic process;programmed cell death;sphingolipid metabolic process Sphingolipid metabolism 9 9 9 20.6 20.6 20.6 63.523 1.3931E-22 16900000 9996200 6903800 2658 IPI:IPI00099463.2 Sphingosine-1-phosphate lyase 1;Sphingosine-1-phosphate aldolase SGPL1;KIAA1252 O95470 ENST00000299297;ENST00000373202;ENST00000409118 K01634 1 NaN 1.1862 NaN NaN 0.77507 NaN bZIP_Maf cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;sequence-specific DNA binding;transcription factor activity;transcription regulator activity nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent 2 2 2 23.8 23.8 23.8 17.76 3.4332E-17 216600 95024 121580 2659 IPI:IPI00099497.2 Transcription factor MafF;V-maf musculoaponeurotic fibrosarcoma oncogene homolog F MAFF Q9ULX9 ENST00000338483;ENST00000407965 K09037 1 1.0309 1.7305 1.0105 1.2654 1.2119 1.2224 UBA;ubiquitin cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;perinuclear region of cytoplasm;protein complex binding;enzyme binding;kinase binding;protein binding 12 12 7 32.9 32.9 25.8 62.518 0 1859200000 924960000 934260000 2660 IPI:IPI00099550.1;IPI:IPI00071180.1 Ubiquilin-1;Protein linking IAP with cytoskeleton 1 UBQLN1;DA41;PLIC1 Q9UMX0-1;Q9UMX0;Q9UMX0-2 ENST00000257468;ENST00000376395 K04523 2 0.65488 1.6296 NaN 0.79086 1.0742 NaN Sulfotransfer_2 cell part;cytoplasmic part;Golgi apparatus part;Golgi membrane;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part catalytic activity;chondroitin 4-sulfotransferase activity;chondroitin sulfotransferase activity;N-acetylgalactosamine 4-O-sulfotransferase activity;sulfotransferase activity;transferase activity;transferase activity, transferring sulfur-containing groups aminoglycan biosynthetic process;aminoglycan metabolic process;carbohydrate metabolic process;glycosaminoglycan biosynthetic process;polysaccharide biosynthetic process;polysaccharide metabolic process;sulfur metabolic process Chondroitin sulfate biosynthesis;Sulfur metabolism 3 3 3 11.4 11.4 11.4 41.554 1.7044E-07 13478000 7174900 6302900 2661 IPI:IPI00099831.1;IPI:IPI00554485.1 Carbohydrate sulfotransferase 11;Chondroitin 4-O-sulfotransferase 1;Chondroitin 4-sulfotransferase 1 CHST11 Q9NPF2-1;Q9NPF2;Q9NPF2-2 ENST00000303694 K01017 2 1.7599 1.0861 NaN 2.5203 0.70834 NaN cell junction;cell part;cell-cell junction;intracellular organelle part;intracellular part;membrane part;nuclear part;nucleoplasm;occluding junction;organelle part;plasma membrane part;tight junction binding;DNA binding;nucleic acid binding;transcription factor activity;transcription regulator activity cellular process;chromatin organization;organelle organization;regulation of biosynthetic process;regulation of gene expression;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent 2 2 2 3 3 3 121.52 6.4891E-06 6121900 2613600 3508300 2662 IPI:IPI00099834.4;IPI:IPI00929172.1 Ubinuclein-1;Ubiquitously expressed nuclear protein;HIRA-binding protein;Protein VT4 UBN1 Q9NPG3-1;Q9NPG3;Q9NPG3-2 ENST00000262376;ENST00000396658 2 0.75829 1.6795 0.65609 1.1059 0.97011 0.93657 MRP-L28 intracellular membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;mitochondrial ribosome;non-membrane-bounded organelle;nucleus;organellar ribosome;organelle;ribonucleoprotein complex;ribosome anatomical structure morphogenesis;developmental process 5 5 5 19.9 19.9 19.9 24.49 1.5539E-07 51908000 26233000 25674000 2664 IPI:IPI00099871.1 39S ribosomal protein L40, mitochondrial;Nuclear localization signal-containing protein deleted in velocardiofacial syndrome;Up-regulated in metastasis MRPL40;NLVCF;URIM Q9NQ50 ENST00000333130 1 0.80545 1.615 0.8353 1.0532 1.0487 1.1038 Fructosamin_kin catalytic activity;kinase activity;transferase activity;transferase activity, transferring phosphorus-containing groups 8 8 8 24.3 24.3 24.3 34.412 3.7444E-64 152240000 82896000 69346000 2665 IPI:IPI00099986.5 Ketosamine-3-kinase;Fructosamine-3-kinase-related protein FN3KRP Q9HA64 ENST00000269373 1 0.68984 1.3964 0.65233 0.90759 0.91457 0.85635 tRNA_m1G_MT cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle binding;catalytic activity;methyltransferase activity;protein binding;transferase activity;transferase activity, transferring one-carbon groups cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;tRNA metabolic process;tRNA processing 13 13 13 36 36 36 47.346 5.1045E-62 169070000 95402000 73670000 2666 IPI:IPI00099996.2 Mitochondrial ribonuclease P protein 1;RNA (guanine-9-)-methyltransferase domain-containing protein 1;Renal carcinoma antigen NY-REN-49;HBV pre-S2 trans-regulated protein 2 RG9MTD1;MRPP1 Q7L0Y3 ENST00000309922 1 1.0388 1.7695 0.8831 1.3156 1.1908 1.1942 Gpi16 cell part;cytoplasmic part;endoplasmic reticulum part;GPI-anchor transamidase complex;intracellular organelle part;intracellular part;macromolecular complex;membrane part;organelle part;protein complex binding;protein binding attachment of GPI anchor to protein;biopolymer metabolic process;biopolymer modification;cellular biopolymer metabolic process;cellular process;macromolecule metabolic process;metabolic process;protein metabolic process;protein modification process Glycosylphosphatidylinositol(GPI)-anchor biosynthesis 8 8 8 14.4 14.4 14.4 65.699 6.8742E-41 90897000 46975000 43922000 2667 IPI:IPI00100030.1;IPI:IPI00401043.1;IPI:IPI00401041.1;IPI:IPI00385011.1 GPI transamidase component PIG-T;Phosphatidylinositol-glycan biosynthesis class T protein PIGT;CGI-06;PSEC0163;UNQ716/PRO1379 Q969N2-1;Q969N2;Q969N2-4;Q969N2-2;Q969N2-3 ENST00000279035;ENST00000279036;ENST00000341555;ENST00000372689 K05292 4 0.67017 1.4492 0.68198 0.8899 0.95582 0.89053 Ric8 cell part;cytoplasm;intracellular part enzyme regulator activity;GTPase regulator activity;guanyl-nucleotide exchange factor activity;nucleoside-triphosphatase regulator activity 11 11 10 22.7 22.7 20.1 60.372 2.3514E-231 326560000 179640000 146920000 2668 IPI:IPI00100106.1;IPI:IPI00746360.1;IPI:IPI00749304.1 Synembryn-A;Protein Ric-8A RIC8A Q9NPQ8-3;Q9NPQ8;Q9NPQ8-1;Q9NPQ8-2 ENST00000325207 3 0.66972 1.1942 0.61078 0.88937 0.79178 0.81473 XRN_N cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part 5'-3' exonuclease activity;5'-3' exoribonuclease activity;binding;catalytic activity;exonuclease activity;exoribonuclease activity;hydrolase activity;nuclease activity;nucleic acid binding;protein binding;ribonuclease activity;zinc ion binding DNA catabolic process;DNA catabolic process, exonucleolytic;DNA metabolic process;mRNA processing;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;RNA processing;transcription termination 21 21 21 27.6 27.6 27.6 108.58 3.5086E-211 1852900000 1220000000 632920000 2669 IPI:IPI00100151.4;IPI:IPI00788157.1 5'-3' exoribonuclease 2;DHM1-like protein XRN2 Q9H0D6-1;Q9H0D6;Q9H0D6-2 ENST00000377191 K01146 2 1.0299 1.8166 0.97882 1.2997 1.2217 1.2655 C2;CUE cell part;cytoplasm;interleukin-1 receptor complex;interleukin-18 receptor complex;intracellular part;macromolecular complex;membrane part;plasma membrane part;protein complex;receptor complex binding;molecular transducer activity;protein binding;receptor binding;signal transducer activity;Toll binding cell activation;cell communication;defense response;immune response;immune system process;inflammatory response;intracellular signaling cascade;phosphate metabolic process;phosphorus metabolic process;response to stress;signal transduction Toll-like receptor signaling pathway 4 4 4 19 19 19 30.281 1.2894E-93 166960000 86734000 80223000 2670 IPI:IPI00100154.1 Toll-interacting protein TOLLIP Q9H0E2 ENST00000317204;ENST00000382211 K05402 1 0.70698 1.5093 0.75721 0.92681 0.99429 0.9779 HEAT;TIP120 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;protein complex;ubiquitin ligase complex binding;protein binding biosynthetic process;catabolic process;macromolecule catabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein modification process;proteolysis;transcription 46 46 44 40.5 40.5 39.3 136.37 0 5624200000 3005700000 2618500000 2671 IPI:IPI00100160.3;IPI:IPI00604431.1;IPI:IPI00915424.1 Cullin-associated NEDD8-dissociated protein 1;Cullin-associated and neddylation-dissociated protein 1;p120 CAND1;TBP-interacting protein TIP120A;TBP-interacting protein of 120 kDa A CAND1;KIAA0829;TIP120;TIP120A Q86VP6-1;Q86VP6;Q86VP6-2 ENST00000299218;ENST00000393557 3 0.86538 1.586 0.89112 1.1808 1.0185 1.1902 Adaptin_binding cell part;cytoplasm;intracellular part establishment of localization;establishment of protein localization;protein transport;transport 2 2 2 7.3 7.3 7.3 34.593 3.1423E-30 26719000 14133000 12585000 2672 IPI:IPI00100193.4 Alpha- and gamma-adaptin-binding protein p34 Q6PD74 ENST00000261880 1 0.94267 1.7534 1.0521 1.2097 1.1724 1.3643 SEP;UBX cell part;cytoplasmic part;Golgi apparatus part;Golgi stack;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;nucleus;organelle;organelle part binding;lipid binding;protein binding 10 10 10 37.1 37.1 37.1 40.816 3.9434E-141 363230000 184860000 178380000 2673 IPI:IPI00397571.1;IPI:IPI00100197.3;IPI:IPI00022830.3 NSFL1 cofactor p47;p97 cofactor p47;UBX domain-containing protein 2C NSFL1C;UBXN2C Q9UNZ2-5;Q9UNZ2;Q9UNZ2-1;Q9UNZ2-4 ENST00000216879;ENST00000353088;ENST00000381673 3 0.94678 2.3533 NaN 1.1991 1.609 NaN Ribonuc_red_sm cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;ion binding;iron ion binding;oxidoreductase activity;oxidoreductase activity, acting on CH or CH2 groups;oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor;ribonucleoside-diphosphate reductase activity DNA metabolic process;DNA repair;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;response to DNA damage stimulus;response to stress Glutathione metabolism;p53 signaling pathway;Purine metabolism;Pyrimidine metabolism 4 1 1 11.7 3.1 3.1 40.736 6.0465E-35 2944500 1611600 1332900 2674 IPI:IPI00100213.2;IPI:IPI00741117.1 Ribonucleoside-diphosphate reductase subunit M2 B;TP53-inducible ribonucleotide reductase M2 B;p53-inducible ribonucleotide reductase small subunit 2-like protein RRM2B;P53R2 Q7LG56-1;Q7LG56;Q7LG56-2 ENST00000251810;ENST00000395910;ENST00000395912 K10808 2 0.79199 1.5948 0.83159 1.0314 1.0889 1.0528 RNA_pol_Rpc34 cell part;DNA-directed RNA polymerase complex;DNA-directed RNA polymerase III complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;RNA polymerase complex binding;catalytic activity;DNA binding;DNA-directed RNA polymerase activity;nucleic acid binding;nucleotidyltransferase activity;protein binding;RNA polymerase activity;transferase activity;transferase activity, transferring phosphorus-containing groups metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase III promoter;regulation of transcription, DNA-dependent;transcription RNA polymerase 5 5 5 17.4 17.4 17.4 35.684 1.2755E-16 67249000 35071000 32177000 2676 IPI:IPI00100245.1 DNA-directed RNA polymerase III subunit RPC6;DNA-directed RNA polymerase III subunit F;DNA-directed RNA polymerase III 39 kDa polypeptide;RPC39 POLR3F Q9H1D9 ENST00000377603 K03025 1 NaN 1.3628 NaN NaN 0.93052 NaN Thioredoxin cell part;cytoplasmic part;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane part;membrane-bounded organelle;mitochondrion;organelle cell redox homeostasis;cellular homeostasis;cellular metabolic process;cellular process;electron transport chain;generation of precursor metabolites and energy;homeostatic process;metabolic process;regulation of biological process;transport 3 3 3 12 12 12 38.952 5.9965E-34 5988100 2983800 3004300 2677 IPI:IPI00100247.3 Thioredoxin-related transmembrane protein 4;Thioredoxin domain-containing protein 13 TMX4;KIAA1162;TXNDC13;PSEC0095;UNQ475/PRO938 Q9H1E5 ENST00000246024 1 NaN NaN 0.89346 NaN NaN 1.203 Ins134_P3_kin cell part;intracellular ATP binding;binding;catalytic activity;inositol or phosphatidylinositol kinase activity;kinase activity;magnesium ion binding;nucleoside binding;nucleotide binding;purine nucleoside binding;transferase activity alcohol metabolic process;cell communication;cellular process;inositol metabolic process;inositol phosphate metabolic process;inositol trisphosphate metabolic process;metabolic process;polyol metabolic process;signal transduction Inositol phosphate metabolism;Phosphatidylinositol signaling system 2 2 2 5.6 5.6 5.6 45.621 4.0744E-06 1409800 705940 703840 2678 IPI:IPI00100329.7;IPI:IPI00953716.1 Inositol-tetrakisphosphate 1-kinase;Inositol-triphosphate 5/6-kinase;Inositol 1,3,4-trisphosphate 5/6-kinase;Ins(1,3,4)P(3) 5/6-kinase ITPK1 Q13572-1;Q13572;Q13572-2 ENST00000267615;ENST00000311458;ENST00000354313;ENST00000405174 K00913;K01765 2 0.59902 1.1217 0.57424 0.85035 0.78759 0.74647 GAD;tRNA_anti;tRNA-synt_2 cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part aminoacyl-tRNA ligase activity;aspartate-tRNA ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-oxygen bonds;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding aspartyl-tRNA aminoacylation;cellular amino acid and derivative metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;tRNA aminoacylation for protein translation;tRNA metabolic process Alanine and aspartate metabolism;Aminoacyl-tRNA biosynthesis 8 8 8 13.8 13.8 13.8 73.562 3.4263E-13 22917000 12868000 10049000 2679 IPI:IPI00100460.2 Aspartyl-tRNA synthetase, mitochondrial;Aspartate--tRNA ligase DARS2 Q6PI48 ENST00000361951 K01876 1 NaN 1.8509 NaN NaN 1.1312 NaN zf-HIT binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding 3 3 3 6 6 6 53.918 0.0017027 1008100 774610 233440 2680 IPI:IPI00100468.4 Zinc finger HIT domain-containing protein 6;Serologically defined breast cancer antigen NY-BR-75 ZNHIT6;C1orf181 Q9NWK9 ENST00000370574 1 0.66784 1.1949 0.084938 0.85143 0.85582 0.11269 YEATS cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;RNA polymerase II transcription factor activity;transcription regulator activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent 2 2 2 4.3 4.3 4.3 62.055 7.591E-06 52800000 29134000 23665000 2681 IPI:IPI00100630.6 Protein ENL;YEATS domain-containing protein 1 MLLT1;ENL;LTG19;YEATS1 Q03111 ENST00000252674 1 0.84257 1.4527 0.7549 1.0666 1.0124 1.0337 Steroid_dh cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on the CH-CH group of donors biosynthetic process;cellular biosynthetic process;cellular metabolic process;cellular process;lipid biosynthetic process;lipid metabolic process;metabolic process;primary metabolic process;steroid biosynthetic process;steroid metabolic process Biosynthesis of unsaturated fatty acids 8 8 8 25.6 25.6 25.6 36.034 1.7094E-39 431430000 233550000 197880000 2682 IPI:IPI00100656.3;IPI:IPI00301279.3 Synaptic glycoprotein SC2;Trans-2,3-enoyl-CoA reductase GPSN2;SC2 Q9NZ01-1;Q9NZ01 ENST00000215567 K10258 2 0.92663 1.7913 1.0688 1.2637 1.0715 1.5666 TB2_DP1_HVA22 cell part;integral to membrane;intrinsic to membrane;membrane part 3 3 3 12.1 12.1 12.1 29.395 9.3701E-14 22599000 11963000 10636000 2684 IPI:IPI00100674.1;IPI:IPI00384331.1 Receptor expression-enhancing protein 4 REEP4;C8orf20;PP432 Q9H6H4-1;Q9H6H4;Q9H6H4-2 ENST00000306306;ENST00000334530 2 0.83892 1.5332 0.89801 1.0444 1.0559 1.1507 binding;enzyme inhibitor activity;enzyme regulator activity;protein binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 9 9 9 29.4 29.4 29.4 44.483 3.0894E-52 208330000 102810000 105520000 2685 IPI:IPI00100748.4;IPI:IPI00442503.1 Hsp70-binding protein 1;Heat shock protein-binding protein 1 HSPBP1;HSPBP;PP1845 Q9NZL4-1;Q9NZL4 ENST00000255631;ENST00000376343 K09562 2 0.89455 2.1976 1.0326 1.0991 1.5679 1.3238 DUF498 3 3 3 29.5 29.5 29.5 13.332 1.386E-06 60228000 30965000 29263000 2686 IPI:IPI00100775.1;IPI:IPI00022308.1;IPI:IPI00748229.1 UPF0366 protein C11orf67 C11orf67;PTD015 Q9H7C9-1;Q9H7C9;Q9H7C9-2;Q9H7C9-3 ENST00000263301;ENST00000304716;ENST00000393427 K09008 3 NaN 0.30086 NaN NaN 0.21289 NaN Tfb4 carboxy-terminal domain protein kinase complex;cell part;core TFIIH complex;holo TFIIH complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex binding;damaged DNA binding;DNA binding;nucleic acid binding;protein binding;RNA polymerase II transcription factor activity;transcription factor activity;translation factor activity, nucleic acid binding;zinc ion binding DNA catabolic process;DNA metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleotide-excision repair, DNA damage removal;regulation of transcription, DNA-dependent;RNA elongation;transcription initiation Basal transcription factors;Nucleotide excision repair 3 3 3 14.3 14.3 14.3 34.378 8.3566E-07 6538700 2944500 3594200 2687 IPI:IPI00100791.3 General transcription factor IIH subunit 3;General transcription factor IIH polypeptide 3;TFIIH basal transcription factor complex p34 subunit;Basic transcription factor 2 34 kDa subunit;BTF2-p34 GTF2H3 Q13889 ENST00000228955 K03143 1 0.85027 1.742 0.84842 1.2394 1.0643 1.1219 Snf7 cell part;cytoplasmic part;cytosol;endosomal part;endosome membrane;intracellular organelle part;intracellular part;membrane;organelle membrane;organelle part binding;protein binding establishment of localization;establishment of protein localization;protein transport;transport 4 4 4 22.8 22.8 22.8 24.57 2.3054E-68 266420000 143420000 123000000 2688 IPI:IPI00100796.4 Charged multivesicular body protein 5;Chromatin-modifying protein 5;Vacuolar protein-sorting-associated protein 60;SNF7 domain-containing protein 2 CHMP5;C9orf83;SNF7DC2;CGI-34;HSPC177;PNAS-2;PNAS-114 Q9NZZ3 ENST00000223500 K12198 1 0.7386 1.2671 0.70714 0.97107 0.91469 0.94969 PTE binding;catalytic activity;cation binding;hydrolase activity;hydrolase activity, acting on ester bonds;ion binding;metal ion binding;transition metal ion binding;zinc ion binding catabolic process;metabolic process 7 7 7 23.2 23.2 23.2 39.017 1.4912E-36 82145000 45094000 37051000 2689 IPI:IPI00100933.1;IPI:IPI00903152.1 Phosphotriesterase-related protein;Parathion hydrolase-related protein;HPHRP PTER Q96BW5-1;Q96BW5;Q96BW5-2 ENST00000298942;ENST00000343656;ENST00000378000 K07048 2 NaN 1.1728 0.81725 NaN 0.81773 1.0632 2 2 2 10.2 10.2 10.2 30.529 5.5373E-12 5840300 3049600 2790700 2690 IPI:IPI00100947.3 Leukocyte receptor cluster member 1 LENG1 Q96BZ8 ENST00000222224 1 0.72185 1.345 0.73663 0.96696 0.91563 0.98213 binding 7 7 7 10.6 10.6 10.6 74.582 1.2658E-39 69182000 38099000 31083000 2691 IPI:IPI00100984.4;IPI:IPI00155577.1;IPI:IPI00409555.1 HEAT repeat-containing protein 3 HEATR3 Q7Z4Q2-1;Q7Z4Q2;Q7Z4Q2-2 ENST00000299192;ENST00000401635;ENST00000405152 3 0.62044 1.1926 0.64311 0.8355 0.77407 0.86386 4 4 4 31.6 31.6 31.6 19.291 6.2552E-23 100640000 55955000 44689000 2692 IPI:IPI00101095.3 UPF0687 protein C20orf27 C20orf27 Q9GZN8 ENST00000379765;ENST00000379772;ENST00000399672 1 1.0441 1.7702 1.1937 1.2508 1.289 1.4441 HCaRG cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding 3 3 3 21.4 21.4 21.4 24.67 8.3008E-42 37444000 18853000 18591000 2693 IPI:IPI00101106.3 COMM domain-containing protein 5;Hypertension-related calcium-regulated gene protein COMMD5;HT002 Q9GZQ3 ENST00000305103;ENST00000402718 1 0.38855 1.0957 NaN 0.48259 0.78094 NaN mTERF cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;nucleus;organelle 4 4 4 10.8 10.8 10.8 47.971 6.9188E-34 7958500 3706300 4252200 2694 IPI:IPI00101163.5;IPI:IPI00798150.1 mTERF domain-containing protein 1, mitochondrial MTERFD1;CGI-12 Q96E29-1;Q96E29;Q96E29-2 ENST00000287025 2 0.46625 0.89319 0.4777 0.63649 0.57752 0.61555 NUC173 integral to membrane;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane;membrane part;non-membrane-bounded organelle;nuclear membrane;nucleolus;organelle;organelle membrane;organelle part binding;protein binding 24 24 24 24.5 24.5 24.5 143.7 0 877570000 505720000 371850000 2695 IPI:IPI00101186.6;IPI:IPI00940901.1 RRP12-like protein RRP12;KIAA0690 Q5JTH9-1;Q5JTH9;Q5JTH9-2 ENST00000315563;ENST00000370992 2 0.75321 1.711 0.73741 1.0232 1.0632 0.98309 large ribosomal subunit;macromolecular complex;mitochondrial large ribosomal subunit;mitochondrial small ribosomal subunit;organellar large ribosomal subunit;organellar small ribosomal subunit;ribonucleoprotein complex;small ribosomal subunit binding;protein binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 6 6 6 29.9 29.9 29.9 19.015 4.6376E-20 39136000 20861000 18275000 2696 IPI:IPI00101258.1 28S ribosomal protein S24, mitochondrial;MRP-S24;bMRP-47 MRPS24;HSPC335 Q96EL2 ENST00000317534 1 0.76385 1.6061 0.97849 0.96511 1.0851 1.2035 EMP70 cell part;integral to membrane;intrinsic to membrane;membrane part 4 4 1 5.5 5.5 1.3 92.485 3.8359E-77 134740000 67202000 67537000 2697 IPI:IPI00101374.6 Transmembrane 9 superfamily member 1 TM9SF1 O15321 ENST00000261789 1 NaN 1.9444 NaN NaN 1.23 NaN EAP30 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle RNA polymerase II transcription factor activity;transcription regulator activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription;transport 3 3 3 15.1 15.1 15.1 28.864 6.599E-38 9077700 5673200 3404500 2698 IPI:IPI00101524.3;IPI:IPI00640699.1 Vacuolar-sorting protein SNF8;ESCRT-II complex subunit VPS22;ELL-associated protein of 30 kDa SNF8;EAP30 Q96H20-1;Q96H20;Q96H20-2 ENST00000290330 K12188 2 0.68776 1.0169 0.56627 0.89851 0.65207 0.71499 centriole;cytoplasmic part;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;microtubule organizing center part;non-membrane-bounded organelle;organelle;organelle part cell cycle phase;cell cycle process;cell division;cellular component organization;cellular process;mitosis;nuclear division;organelle fission;organelle organization 6 6 6 15.7 15.7 15.7 54.124 7.4183E-116 56382000 31959000 24423000 2699 IPI:IPI00101532.5;IPI:IPI00478943.3 Centrosomal protein of 55 kDa;Up-regulated in colon cancer 6 CEP55;C10orf3;URCC6 Q53EZ4-1;Q53EZ4;Q53EZ4-2 ENST00000358339;ENST00000371485 2 0.52126 1.0424 0.48686 0.69511 0.65859 0.65106 CwfJ_C_1;CwfJ_C_2 catalytic activity 15 15 15 31.2 31.2 31.2 60.618 3.6156E-186 299280000 172550000 126740000 2700 IPI:IPI00101600.5;IPI:IPI00478313.2;IPI:IPI00386343.1 CWF19-like protein 1 CWF19L1 Q69YN2-1;Q69YN2;Q69YN2-3 ENST00000354105 3 NaN NaN 0.91647 NaN NaN 1.1091 AdoHcyase;AdoHcyase_NAD adenosylhomocysteinase activity;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ether bonds;trialkylsulfonium hydrolase activity cellular metabolic process;cellular process;metabolic process;one-carbon metabolic process Methionine metabolism;Selenoamino acid metabolism 10 2 2 13.9 3.3 3.3 66.72 1.212E-56 11059000 5724900 5334100 2701 IPI:IPI00101645.3 Putative adenosylhomocysteinase 3;S-adenosyl-L-homocysteine hydrolase 3;S-adenosylhomocysteine hydrolase-like protein 2 AHCYL2;KIAA0828 Q96HN2 ENST00000325006 K01251 1 0.59519 1.1386 0.63657 0.73507 0.81081 0.85544 Aminotran_5 cell part;cytoplasmic part;cytosol;intracellular part binding;carbon-sulfur lyase activity;catalytic activity;cofactor binding;lipid binding;lyase activity;pyridoxal phosphate binding;selenocysteine lyase activity;steroid binding;transferase activity;vitamin B6 binding;vitamin binding metabolic process Selenoamino acid metabolism 9 9 9 34.4 34.4 34.4 48.148 1.1916E-80 75936000 40755000 35182000 2702 IPI:IPI00101652.4;IPI:IPI00884890.1 Selenocysteine lyase SCLY;SCL Q96I15-1;Q96I15;Q96I15-2 ENST00000254663 K01763 2 0.44258 0.73742 0.3924 0.54767 0.48956 0.51615 Nol1_Nop2_Fmu catalytic activity;methyltransferase activity;transferase activity;transferase activity, transferring one-carbon groups 14 14 14 36.1 36.1 36.1 50.41 3.9444E-93 153620000 89880000 63737000 2703 IPI:IPI00101659.6;IPI:IPI00164154.3;IPI:IPI00470560.4;IPI:IPI00807665.1;IPI:IPI00807644.1;IPI:IPI00807345.2;IPI:IPI00167076.2;IPI:IPI00807411.1;IPI:IPI00807684.1;IPI:IPI00167075.3 Putative methyltransferase NSUN5;NOL1/NOP2/Sun domain family member 5;Williams-Beuren syndrome chromosomal region 20A protein NSUN5;WBSCR20;WBSCR20A Q96P11-2;Q96P11;Q96P11-1 ENST00000252594;ENST00000310326 10 0.79953 1.6283 0.63923 1.0197 1.0883 0.81305 tRNA_anti;tRNA-synt_2 cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part aminoacyl-tRNA ligase activity;asparagine-tRNA ligase activity;aspartate-tRNA ligase activity;ATP binding;binding;catalytic activity;ligase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding asparaginyl-tRNA aminoacylation;aspartyl-tRNA aminoacylation;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;tRNA aminoacylation for protein translation;tRNA metabolic process Alanine and aspartate metabolism;Aminoacyl-tRNA biosynthesis 6 6 6 12.4 12.4 12.4 54.076 1.1872E-59 37653000 19838000 17815000 2704 IPI:IPI00101664.2 Probable asparaginyl-tRNA synthetase, mitochondrial;Asparagine--tRNA ligase NARS2 Q96I59 ENST00000281038 K01893 1 1.1382 2.2094 1.0098 1.5668 1.5794 1.4902 6 6 6 19.6 19.6 19.6 40.262 4.1079E-16 91727000 46369000 45358000 2705 IPI:IPI00101734.5 Protein FAM105B FAM105B Q96BN8 ENST00000284274 1 0.61594 NaN 0.68291 0.77023 NaN 0.87133 Hexapep;NTP_transferase binding;catalytic activity;GTP binding;mannose-1-phosphate guanylyltransferase activity;mannose-phosphate guanylyltransferase activity;nucleotide binding;transferase activity;transferase activity, transferring phosphorus-containing groups biosynthetic process;metabolic process Fructose and mannose metabolism 4 4 4 12.9 12.9 12.9 52.017 3.0912E-67 24616000 13787000 10828000 2706 IPI:IPI00657888.1;IPI:IPI00101782.3 Mannose-1-phosphate guanyltransferase alpha;GTP-mannose-1-phosphate guanylyltransferase alpha;GDP-mannose pyrophosphorylase A GMPPA Q96IJ6-2;Q96IJ6;Q96IJ6-1 ENST00000313597;ENST00000341142;ENST00000358215;ENST00000373908;ENST00000373917 K00971 2 0.98833 1.6842 0.91344 1.1964 1.191 1.1046 DUF6;TPT cell part;integral to membrane;intrinsic to membrane;membrane part establishment of localization;transport 7 7 7 22.7 22.7 22.7 44.772 0 106620000 53908000 52708000 2707 IPI:IPI00101952.5;IPI:IPI00410697.3 Solute carrier family 35 member E1 SLC35E1;PSEC0038 Q96K37-1;Q96K37;Q96K37-2 ENST00000248069;ENST00000355538;ENST00000409648 2 0.78823 1.4858 0.84818 1.0373 0.98611 1.0824 Cofilin_ADF;SH3_1 cell cortex;cell part;cell projection;cytoplasmic part;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;lamellipodium;non-membrane-bounded organelle;organelle binding;enzyme activator activity;enzyme regulator activity;identical protein binding;protein binding activation of MAPK activity;endocytosis;immune system process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;regulation of protein amino acid phosphorylation;transport 8 8 8 24.6 24.6 24.6 49.042 8.4708E-92 503820000 252260000 251560000 2708 IPI:IPI00101968.3;IPI:IPI00396437.3;IPI:IPI00456925.3 Drebrin-like protein;Drebrin-F;SH3 domain-containing protein 7;Cervical SH3P7;HPK1-interacting protein of 55 kDa;Cervical mucin-associated protein DBNL;CMAP;SH3P7;PP5423 Q9UJU6-3;Q9UJU6;Q9UJU6-2;Q9UJU6-1 ENST00000258780;ENST00000389369 3 0.67432 1.3157 0.70969 0.90836 0.83587 0.92981 PCI cell part;cytoplasmic part;eukaryotic translation initiation factor 3 complex;intracellular part;macromolecular complex;protein complex binding;nucleic acid binding;protein binding;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity cellular process;translational initiation 18 18 18 44.9 44.9 44.9 42.502 0 1363300000 729720000 633600000 2710 IPI:IPI00102069.5 Eukaryotic translation initiation factor 3 subunit M;PCI domain-containing protein 1;Fetal lung protein B5 EIF3M;HFLB5;PCID1;GA17;PNAS-125 Q7L2H7 ENST00000323213 1 NaN 1.5229 0.88655 NaN 1.0019 1.2671 UQ_con cell part;cytoplasm;cytoplasmic part;cytosol;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;nucleoplasm;organelle;organelle part acid-amino acid ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleoside binding;nucleotide binding;purine nucleoside binding;ubiquitin-protein ligase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein metabolic process;protein modification process;proteolysis;regulation of metabolic process Ubiquitin mediated proteolysis 3 3 3 16.9 16.9 16.9 22.255 6.9406E-06 15253000 8211300 7041500 2712 IPI:IPI00102173.3;IPI:IPI00056504.1;IPI:IPI00021346.1 Ubiquitin-conjugating enzyme E2 E2;Ubiquitin-protein ligase E2;Ubiquitin carrier protein E2;UbcH8;Ubiquitin-conjugating enzyme E2 E3;Ubiquitin-protein ligase E3;Ubiquitin carrier protein E3;Ubiquitin-conjugating enzyme E2-23 kDa;UbcH9;UbcM2;Ubiquitin-conjugating enzyme E2 E1;Ubiquitin-protein ligase E1;Ubiquitin carrier protein E1;UbcH6 UBE2E2;UBCH8;UBE2E3;UBCE4;UBCH9;UBE2E1;UBCH6 Q96LR5;Q969T4;P51965 ENST00000335798;ENST00000396703;ENST00000305934;ENST00000392415;ENST00000409247;ENST00000410062;ENST00000410114;ENST00000306627 K06689 3 0.87543 1.4351 0.83237 1.1053 0.89721 1.1146 SRA1 cell part;cytoplasm;intracellular part;macromolecular complex;ribonucleoprotein complex molecular transducer activity;receptor activity;signal transducer activity apoptosis;biosynthetic process;cell death;cell proliferation;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription 8 8 8 40.5 40.5 40.5 25.843 8.7827E-23 45010000 22013000 22997000 2713 IPI:IPI00102313.3 Steroid receptor RNA activator 1;Steroid receptor RNA activator protein SRA1;PP7684 Q9HD15 ENST00000336283 1 0.39469 1.2832 0.38536 0.58765 0.80214 0.51291 Aa_trans cell part;integral to membrane;intrinsic to membrane;membrane;membrane part;plasma membrane 3 3 3 9.1 9.1 9.1 51.457 0.0011987 18480000 10647000 7833500 2714 IPI:IPI00102509.4;IPI:IPI00641465.1 Sodium-coupled neutral amino acid transporter 5;System N transporter 2;Solute carrier family 38 member 5 SLC38A5;JM24;SN2;SNAT5;PP7194 Q8WUX1-1;Q8WUX1 ENST00000376876 2 NaN 1.2809 NaN NaN 0.85571 NaN Myotub-related cell part;cytoplasm;intracellular part catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;phosphatase activity;phosphoric ester hydrolase activity cellular metabolic process;cellular process;dephosphorylation;metabolic process;phosphate metabolic process;phosphorus metabolic process 2 2 2 3.8 3.8 3.8 63.461 7.9067E-08 4030000 2314200 1715800 2715 IPI:IPI00102580.1 Myotubularin-related protein 9 MTMR9;C8orf9;MTMR8 Q96QG7 ENST00000221086 1 NaN 0.88718 NaN NaN 0.63498 NaN cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial nucleoid;mitochondrial part;nucleoid;organelle part ATP binding;binding;catalytic activity;DNA helicase activity;helicase activity;hydrolase activity;nucleoside binding;nucleotide binding;protease binding;protein binding;purine nucleoside binding;pyrophosphatase activity biosynthetic process;cell death;cellular process;death;DNA metabolic process;DNA replication;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2 2 2 4.2 4.2 4.2 77.153 5.0005E-07 307060 152040 155020 2716 IPI:IPI00102660.1;IPI:IPI00640641.1;IPI:IPI00654621.1 Twinkle protein, mitochondrial;T7 gp4-like protein with intramitochondrial nucleoid localization;T7-like mitochondrial DNA helicase;Progressive external ophthalmoplegia 1 protein PEO1;C10orf2 Q96RR1-1;Q96RR1;Q96RR1-2;Q96RR1-3 ENST00000311916 3 0.7635 1.4264 0.7112 1.0409 0.89617 0.94919 FCH;SH3_1 cell cortex;cytoplasmic vesicle;cytoskeleton;intracellular membrane-bounded organelle;intracellular organelle;lysosome;lytic vacuole;membrane;membrane-bounded organelle;non-membrane-bounded organelle;organelle;plasma membrane;vacuole;vesicle binding;identical protein binding;lipid binding;protein binding cellular component organization;cellular process;endocytosis;establishment of localization;membrane invagination;membrane organization;transport;vesicle-mediated transport 12 12 12 20.6 20.6 20.6 71.306 5.2586E-73 259020000 134800000 124220000 2717 IPI:IPI00807625.1;IPI:IPI00102670.5;IPI:IPI00647034.2;IPI:IPI00807407.1 Formin-binding protein 1;Formin-binding protein 17 FNBP1;FBP17;KIAA0554 Q96RU3-1;Q96RU3;Q96RU3-2;Q96RU3-3;Q96RU3-4 ENST00000335141;ENST00000372416;ENST00000398551 4 0.74319 1.6751 0.77038 1.0379 1.1061 1.0007 RRM_1;SPOC cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of metabolic process;regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 10 10 10 14.5 14.5 14.5 107.19 3.0646E-41 60691000 33270000 27421000 2719 IPI:IPI00102752.2;IPI:IPI00220717.2;IPI:IPI00220716.2 Putative RNA-binding protein 15;RNA-binding motif protein 15;One-twenty two protein 1 RBM15;OTT;OTT1 Q96T37-1;Q96T37;Q96T37-3;Q96T37-2 ENST00000294837;ENST00000369784 3 0.64203 1.4499 0.68218 0.89982 0.89129 0.96512 CBF;NOC3p cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear body;nuclear part;nuclear speck;nucleolus;nucleoplasm part;organelle;organelle part 17 17 17 25.2 25.2 25.2 92.547 1.935E-248 462330000 259740000 202590000 2720 IPI:IPI00102815.1 Nucleolar complex protein 3 homolog;NOC3-like protein;Nucleolar complex-associated protein 3-like protein;Factor for adipocyte differentiation 24 NOC3L;AD24;C10orf117;FAD24 Q8WTT2 ENST00000371361 1 0.93534 1.5915 1.0555 1.1723 1.0725 1.2528 cell part;cytoplasm;extracellular region;intracellular part apoptosis;cell death;cellular process;death;programmed cell death 8 8 8 68.8 68.8 68.8 20.694 5.5466E-281 1751600000 845290000 906320000 2721 IPI:IPI00102821.4;IPI:IPI00885163.2;IPI:IPI00382735.1;IPI:IPI00952710.1 Proapoptotic caspase adapter protein PACAP;HSPC190 Q8WU39-1;Q8WU39 ENST00000302125 4 0.55565 1.6428 NaN 0.72526 1.14 NaN ArfGap cell part;cytoplasm;intracellular part ARF GTPase activator activity;binding;cation binding;enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;ion binding;metal ion binding;small GTPase regulator activity;zinc ion binding biological regulation;regulation of ARF GTPase activity;regulation of catalytic activity;regulation of GTPase activity;regulation of hydrolase activity;regulation of molecular function;regulation of Ras GTPase activity 3 3 3 10 10 10 46.785 2.1957E-52 8176800 4363300 3813500 2722 IPI:IPI00102856.3;IPI:IPI00645261.1 Stromal membrane-associated protein 2;Stromal membrane-associated protein 1-like SMAP2;SMAP1L Q8WU79-1;Q8WU79;Q8WU79-2 ENST00000372718 2 0.71124 1.3291 0.62492 0.88733 0.85299 0.83929 Hexokinase_1;Hexokinase_2 cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;membrane;mitochondrial membrane;mitochondrial outer membrane;mitochondrial part;organelle membrane;organelle outer membrane;organelle part;outer membrane ATP binding;binding;catalytic activity;hexokinase activity;kinase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups alcohol metabolic process;carbohydrate metabolic process;catabolic process;cellular process;generation of precursor metabolites and energy;glucose catabolic process;glucose metabolic process;glycolysis;metabolic process;monosaccharide metabolic process Aminosugars metabolism;Fructose and mannose metabolism;Galactose metabolism;Glycolysis / Gluconeogenesis;Insulin signaling pathway;Starch and sucrose metabolism;Streptomycin biosynthesis;Type II diabetes mellitus 24 21 21 31.8 28.5 28.5 102.38 0 436730000 237390000 199330000 2723 IPI:IPI00102864.3 Hexokinase-2;Hexokinase type II;Muscle form hexokinase HK2 P52789 ENST00000290573 K00844 1 0.95154 1.863 0.97644 1.232 1.2271 1.2006 Ras cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;Golgi apparatus part;Golgi membrane;intracellular organelle part;intracellular part;membrane;membrane part;organelle membrane;organelle part;plasma membrane binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cell communication;cellular process;establishment of protein localization;intracellular signaling cascade;protein transport;regulation of biological process;signal transduction;small GTPase mediated signal transduction;transport;vesicle-mediated transport 13 13 6 60.6 60.6 32.4 24.214 1.9192E-177 587900000 301510000 286390000 2724 IPI:IPI00102896.1 Ras-related protein Rab-2B RAB2B Q8WUD1 ENST00000304034;ENST00000397762 K07878 1 0.35634 NaN NaN 0.446 NaN NaN cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;catalytic activity;kinase activity;protein binding;protein kinase activity;protein serine/threonine kinase activity;transferase activity;transferase activity, transferring phosphorus-containing groups cell cycle checkpoint;DNA damage checkpoint;DNA metabolic process;DNA repair;DNA replication;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to DNA damage stimulus;response to stress 4 4 4 8.2 8.2 8.2 85.837 2.5035E-15 4784000 3059500 1724600 2726 IPI:IPI00103517.1;IPI:IPI00102918.1;IPI:IPI00413576.1 ATR-interacting protein;ATM and Rad3-related-interacting protein ATRIP;AGS1 Q8WXE1-1;Q8WXE1;Q8WXE1-2;Q8WXE1-3 ENST00000320211;ENST00000346691 K10905 3 NaN 1.74 NaN NaN 1.0957 NaN cell junction;clathrin-coated vesicle;coated vesicle;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;intracellular organelle;membrane-bounded organelle;membrane-bounded vesicle;organelle;secretory granule;synaptic vesicle;vesicle 2 2 2 12.9 12.9 12.9 30.211 6.2552E-05 1413600 328270 1085300 2727 IPI:IPI00413578.4;IPI:IPI00102976.4 Tumor protein p63-regulated gene 1-like protein;Mossy fiber terminal-associated vertebrate-specific presynaptic protein;Protein FAM79A TPRG1L;FAM79A;MOVER Q5T0D9-1;Q5T0D9;Q5T0D9-2 ENST00000344579;ENST00000378344 2 0.70221 1.2946 0.68617 0.89711 0.84673 0.87965 AAA cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;DNA binding;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity biosynthetic process;DNA metabolic process;DNA replication;DNA synthesis during DNA repair;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of DNA replication 9 9 9 17.4 17.4 17.4 72.132 2.8643E-76 204070000 75778000 128290000 2728 IPI:IPI00290314.7;IPI:IPI00102997.1;IPI:IPI00645459.1;IPI:IPI00642533.1 ATPase WRNIP1;Werner helicase-interacting protein 1 WRNIP1;WHIP Q96S55-1;Q96S55;Q96S55-2;Q96S55-3;Q96S55-4 ENST00000380771;ENST00000380773 4 1.329 2.8711 1.3556 1.8338 1.7396 1.8365 DUF1387 4 4 4 8.4 8.4 8.4 61.728 7.2669E-85 24580000 12557000 12023000 2729 IPI:IPI00916831.1;IPI:IPI00103027.4 SPATS2-like protein;DNA polymerase-transactivated protein 6 SPATS2L;DNAPTP6;SP1224 Q9NUQ6-1;Q9NUQ6;Q9NUQ6-2 ENST00000360760;ENST00000409140;ENST00000409151;ENST00000409718;ENST00000409755;ENST00000409988 2 0.71444 1.6352 NaN 0.94244 1.0657 NaN Amidohydro_1 catalytic activity;hydrolase activity;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides;N-acetylglucosamine-6-phosphate deacetylase activity alcohol metabolic process;amino sugar metabolic process;carbohydrate metabolic process;glucosamine metabolic process;metabolic process;monosaccharide metabolic process;N-acetylglucosamine metabolic process;primary metabolic process Aminosugars metabolism 6 6 6 15.9 15.9 15.9 46.913 7.1622E-39 9770300 4890800 4879500 2730 IPI:IPI00103028.3;IPI:IPI00477702.4 Putative N-acetylglucosamine-6-phosphate deacetylase;GlcNAc 6-P deacetylase;Amidohydrolase domain-containing protein 2 AMDHD2;CGI-14 Q9Y303-2;Q9Y303;Q9Y303-1 ENST00000293971;ENST00000302956 K01443 2 0.69866 1.3402 0.62607 0.96296 0.84027 0.82465 Adap_comp_sub;Clat_adaptor_s AP-type membrane coat adaptor complex;clathrin adaptor complex;coated pit;Golgi apparatus part;Golgi cisterna;Golgi trans cisterna;intracellular part;macromolecular complex;membrane part;organelle part;organelle subcompartment;protein complex binding;protein binding;transporter activity cellular process;establishment of localization;establishment of localization in cell;establishment of protein localization;intracellular protein transport;intracellular transport;protein transport;transport;vesicle-mediated transport 3 3 3 7.1 7.1 7.1 49.976 0.00010781 111350000 68480000 42874000 2731 IPI:IPI00103040.5 AP-4 complex subunit mu-1;Adapter-related protein complex 4 mu-1 subunit;AP-4 adapter complex mu subunit;Mu subunit of AP-4;Mu4-adaptin;Mu-adaptin-related protein 2 AP4M1;MUARP2 O00189 ENST00000359593 K12402 1 0.83884 1.4772 0.64358 1.0683 0.98439 0.84379 ChaC 4 4 4 25 25 25 20.874 3.2894E-148 56758000 29996000 26761000 2732 IPI:IPI00103047.1 Cation transport regulator-like protein 2 CHAC2 Q8WUX2 ENST00000295304 1 NaN 1.67 0.68669 NaN 1.1351 0.90921 cell part;integral to membrane;intrinsic to membrane;membrane part 3 3 3 30 30 30 14.669 1.5762E-33 33635000 18376000 15259000 2733 IPI:IPI00103057.2;IPI:IPI00607610.1 Protein FAM36A FAM36A Q5RI15-2;Q5RI15;Q5RI15-1 ENST00000366528;ENST00000366529 2 0.79035 1.7182 0.83127 1.0524 1.1727 1.0939 Exo70 cell cortex part;centriolar satellite;cytoplasmic part;cytoskeletal part;cytosol;exocyst;intracellular organelle part;intracellular part;macromolecular complex;membrane;microtubule organizing center part;organelle part;plasma membrane;protein complex cellular process;establishment of localization;establishment of localization in cell;establishment of protein localization;exocytosis;protein transport;secretion;secretion by cell;transport;vesicle-mediated transport Insulin signaling pathway 8 8 8 12.8 12.8 12.8 83.381 1.6302E-54 81817000 63878000 17939000 2734 IPI:IPI00103064.4;IPI:IPI00172532.1;IPI:IPI00641168.1;IPI:IPI00394717.3 Exocyst complex component 7;Exocyst complex component Exo70 EXOC7;EXO70;KIAA1067 Q9UPT5-3;Q9UPT5;Q9UPT5-1;Q9UPT5-2;Q9UPT5-4 ENST00000332065;ENST00000335146;ENST00000357231 K07195 4 1.0851 1.6982 1.0598 1.4021 1.0759 1.429 MIT cell part;cytoplasmic part;endosomal part;endosome membrane;intracellular organelle part;intracellular part;late endosome membrane;membrane;organelle membrane;organelle part establishment of localization;establishment of protein localization;protein transport;transport 3 3 3 12.9 12.9 12.9 29.314 8.3734E-08 11891000 6050700 5840700 2735 IPI:IPI00103065.4 MIT domain-containing protein 1 MITD1 Q8WV92 ENST00000289359 1 NaN NaN 0.70265 NaN NaN 0.87008 Gemin6 Cajal body;cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;nuclear body;nuclear part;nucleoplasm part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;protein binding anatomical structure formation;cellular component assembly;cellular component organization;cellular process;ribonucleoprotein complex assembly;ribonucleoprotein complex biogenesis;spliceosomal snRNP biogenesis;spliceosome assembly 2 2 2 15.6 15.6 15.6 18.824 4.481E-15 24566000 12654000 11912000 2736 IPI:IPI00103087.2 Gem-associated protein 6;SIP2 GEMIN6 Q8WXD5 ENST00000281950 1 0.76096 1.57 0.81085 1.0313 1.0287 1.0201 Leo1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 7 7 7 11.4 11.4 11.4 75.403 4.622E-21 180110000 98750000 81355000 2737 IPI:IPI00103090.2;IPI:IPI00154162.5 RNA polymerase-associated protein LEO1;Replicative senescence down-regulated leo1-like protein LEO1;RDL Q8WVC0-1;Q8WVC0;Q8WVC0-2 ENST00000299601;ENST00000315141 2 0.69659 NaN 0.70965 0.90497 NaN 0.87315 CS cell part;intracellular 3 3 3 24.8 24.8 24.8 17.676 9.0579E-16 161620000 88466000 73153000 2738 IPI:IPI00103142.1 NudC domain-containing protein 2 NUDCD2 Q8WVJ2 ENST00000302764 1 1.0529 2.1836 0.99643 1.3166 1.4432 1.2566 Apyrase cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;Golgi apparatus part;Golgi cisterna membrane;Golgi membrane;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part binding;calcium ion binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;pyrophosphatase activity;signal transducer activity positive regulation of cell communication;positive regulation of protein kinase cascade;positive regulation of signal transduction;regulation of cell communication;regulation of protein kinase cascade;regulation of signal transduction Purine metabolism;Pyrimidine metabolism 3 3 3 8 8 8 44.839 2.0113E-13 5782100 3112100 2670000 2740 IPI:IPI00103175.1;IPI:IPI00413533.2 Soluble calcium-activated nucleotidase 1;Apyrase homolog;Putative MAPK-activating protein PM09;Putative NF-kappa-B-activating protein 107 CANT1;SHAPY Q8WVQ1-1;Q8WVQ1;Q8WVQ1-2 ENST00000302345;ENST00000339300;ENST00000392446 K12304 2 0.77057 0.9725 0.52094 0.92285 0.63766 0.63742 RRM_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;ribonucleoprotein complex binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding cellular biopolymer metabolic process;cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing 10 9 5 24 22.7 12 60.082 3.7794E-45 103980000 57208000 46775000 2741 IPI:IPI00103247.1;IPI:IPI00470410.2 Heterogeneous nuclear ribonucleoprotein L-like;Stromal RNA-regulating factor HNRPLL;SRRF;BLOCK24 Q8WVV9-1;Q8WVV9;Q8WVV9-4 ENST00000272249;ENST00000358367;ENST00000378908 2 0.64381 1.266 0.63788 0.8669 0.82018 0.85297 RWD 2 2 2 15.4 15.4 15.4 21.25 1.2354E-05 14711000 7765100 6946300 2742 IPI:IPI00103252.4 RWD domain-containing protein 4A;Protein FAM28A RWDD4A;FAM28A Q6NW29 ENST00000327570 1 0.72738 1.314 0.86211 0.99342 0.902 1.0165 TruB_N catalytic activity;intramolecular transferase activity;isomerase activity;pseudouridine synthase activity cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;pseudouridine synthesis;RNA modification;RNA processing;tRNA metabolic process;tRNA modification;tRNA processing 4 4 4 15.2 15.2 15.2 37.252 5.4337E-30 52863000 25103000 27760000 2743 IPI:IPI00103341.3 Probable tRNA pseudouridine synthase 1 TRUB1;PUS4 Q8WWH5 ENST00000298746 K03177 1 1.0104 1.382 2.6282 1.277 0.89846 3.2453 AIG1 cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding 2 2 2 9.4 9.4 9.4 41.905 1.4332E-26 52114000 15683000 36431000 2745 IPI:IPI00103387.5 GTPase IMAP family member 1;Immunity-associated protein 1 GIMAP1;IMAP1 Q8WWP7 ENST00000307194 1 0.94539 1.7485 NaN 1.2729 1.0687 NaN SH2;STAT_alpha;STAT_bind;STAT_int cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;calcium ion binding;DNA binding;glucocorticoid receptor binding;nuclear hormone receptor binding;nucleic acid binding;protein binding;receptor binding;steroid hormone receptor binding;transcription factor activity;transcription regulator activity 2-oxoglutarate metabolic process;allantoin metabolic process;citrate metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;oxaloacetate metabolic process;succinate metabolic process Acute myeloid leukemia;Chemokine signaling pathway;Chronic myeloid leukemia;ErbB signaling pathway;Jak-STAT signaling pathway;Pathways in cancer 5 5 5 9.9 9.9 9.9 89.865 5.9712E-44 5584000 3267100 2316900 2746 IPI:IPI00103415.1;IPI:IPI00030783.1 Signal transducer and activator of transcription 5B;Signal transducer and activator of transcription 5A STAT5B;STAT5A;STAT5 P51692;P42229 ENST00000293328;ENST00000345506 K11224;K11223 2 0.65635 1.4101 0.69067 0.89334 0.89734 0.93544 G-patch;Surp cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 5 5 5 8.4 8.4 8.4 72.47 3.1803E-29 10572000 5509600 5062100 2747 IPI:IPI00103419.4;IPI:IPI00337787.1 Splicing factor 4;RNA-binding protein RBP SF4 Q8IWZ8-1;Q8IWZ8 ENST00000247001;ENST00000334782 2 0.74971 1.4293 0.7482 0.90867 0.90936 0.94504 Aldedh cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part aldehyde dehydrogenase (NAD) activity;catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on the aldehyde or oxo group of donors;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor carbohydrate metabolic process;metabolic process;oxidation reduction;primary metabolic process 1,2-Dichloroethane degradation;3-Chloroacrylic acid degradation;Arginine and proline metabolism;Ascorbate and aldarate metabolism;beta-Alanine metabolism;Butanoate metabolism;Fatty acid metabolism;Glycerolipid metabolism;Glycolysis / Gluconeogenesis;Histidine metabolism;Limonene and pinene degradation;Lysine degradation;Propanoate metabolism;Pyruvate metabolism;Tryptophan metabolism;Valine, leucine and isoleucine degradation 8 8 8 15.9 15.9 15.9 57.238 2.3184E-105 54553000 28823000 25730000 2748 IPI:IPI00103467.4 Aldehyde dehydrogenase X, mitochondrial;Aldehyde dehydrogenase family 1 member B1;Aldehyde dehydrogenase 5 ALDH1B1;ALDH5;ALDHX P30837 ENST00000377698 K00128 1 0.70617 1.8462 0.77657 0.98948 1.1963 0.96397 COBRA1 cell part;cytoplasm;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;protein binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 14 14 14 29.8 29.8 29.8 65.697 1.4833E-104 184090000 97588000 86503000 2749 IPI:IPI00103483.1 Negative elongation factor B;Cofactor of BRCA1 COBRA1;KIAA1182;NELFB Q8WX92 ENST00000343053 1 0.80679 1.4553 0.7372 1.0731 0.94708 1.0158 NOPS;RRM_1 cell part;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear matrix;nuclear part;nucleolus;organelle;organelle part binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 13 12 12 30.2 29.1 29.1 58.743 0 959320000 504460000 454870000 2750 IPI:IPI00103525.1;IPI:IPI00395775.6 Paraspeckle component 1;Paraspeckle protein 1 PSPC1;PSP1 Q8WXF1-1;Q8WXF1;Q8WXF1-2 ENST00000335781;ENST00000338910 2 0.87524 1.9153 0.98677 1.1525 1.1967 1.3494 C1_1;RA cell part;cytoplasm;cytoskeletal part;intracellular organelle part;intracellular part;microtubule;organelle part binding;cation binding;diacylglycerol binding;ion binding;lipid binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding apoptosis;cell communication;cell cycle;cell death;cellular process;death;intracellular signaling cascade;negative regulation of biological process;negative regulation of cell cycle;programmed cell death;signal transduction Leukocyte transendothelial migration;Non-small cell lung cancer;Pathways in cancer 7 7 7 16.5 16.5 16.5 47.09 1.0897E-37 44451000 22590000 21862000 2751 IPI:IPI00332633.2;IPI:IPI00183637.4;IPI:IPI00103528.2;IPI:IPI00179101.2 Ras association domain-containing protein 5;New ras effector 1;Regulator for cell adhesion and polarization enriched in lymphoid tissues RASSF5;NORE1;RAPL Q8WWW0-1;Q8WWW0;Q8WWW0-4;Q8WWW0-2;Q8WWW0-3 ENST00000304534;ENST00000355294;ENST00000367117 K08015 4 5.6283 NaN NaN 9.2662 NaN NaN GBP cell part;cytoplasmic part;Golgi apparatus part;Golgi membrane;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleotide binding;pyrophosphatase activity cell death;cellular process;death 2 1 1 4.1 2.2 2.2 63.543 4.3527E-06 125320 3458.7 121860 2752 IPI:IPI00103530.1 Atlastin-1;Guanine nucleotide-binding protein 3;GTP-binding protein 3;Brain-specific GTP-binding protein ATL1;GBP3;SPG3A Q8WXF7 ENST00000357032 1 0.91329 1.4041 NaN 1.1583 0.94305 NaN GATA cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;sequence-specific DNA binding;transcription factor activity;transcription regulator activity;transition metal ion binding;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 6 5 5 13.8 12 12 65.26 2.8671E-71 40502000 21121000 19380000 2753 IPI:IPI00103554.1 Transcriptional repressor p66-beta;p66/p68;GATA zinc finger domain-containing protein 2B GATAD2B;KIAA1150 Q8WXI9 ENST00000368655 1 1.0417 1.4324 0.99028 1.2741 0.9389 1.2324 CAP_GLY centrosome;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;microtubule organizing center;non-membrane-bounded organelle;nucleus;organelle;organelle part;spindle 3 3 3 1.3 1.3 1.3 350.93 1.5591E-05 63345000 34307000 29038000 2754 IPI:IPI00103595.2 Centrosome-associated protein 350;Centrosome-associated protein of 350 kDa CEP350;CAP350;KIAA0480;GM133 Q5VT06 ENST00000367607 1 0.63266 1.3697 0.63536 0.80218 0.95067 0.81887 cell part;integral to membrane;intrinsic to membrane;membrane part 4 4 3 19.5 19.5 16.7 27.835 9.9112E-87 95820000 49560000 46260000 2755 IPI:IPI00103599.1 BRI3-binding protein;Cervical cancer 1 proto-oncogene-binding protein KG19;HCCR-1 BRI3BP;KG19 Q8WY22 ENST00000341446 1 0.82229 1.2888 0.72513 1.0221 0.93519 0.90958 PP2C cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;protein complex;protein serine/threonine phosphatase complex binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;magnesium ion binding;manganese ion binding;phosphatase activity;phosphoprotein phosphatase activity;protein serine/threonine phosphatase activity cellular biopolymer metabolic process;cellular process;dephosphorylation;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid dephosphorylation;protein metabolic process;protein modification process 2 2 2 2.7 2.7 2.7 85.241 1.3502E-15 2479900 1220200 1259700 2756 IPI:IPI00845240.1;IPI:IPI00845435.1;IPI:IPI00103630.2 Protein phosphatase 1E;Ca(2+)/calmodulin-dependent protein kinase phosphatase N;CaMKP-nucleus;Partner of PIX 1;Partner of PIX-alpha PPM1E;CAMKN;KIAA1072;POPX1 Q8WY54-1;Q8WY54;Q8WY54-3;Q8WY54-2 ENST00000308249 K01090 3 0.79394 1.5881 0.88119 1.1335 0.96439 1.2064 PPP4R2 centrosome;cytoplasmic part;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;microtubule organizing center;non-membrane-bounded organelle;organelle;organelle part binding;protein binding cellular process;metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein modification process;RNA metabolic process;RNA processing;RNA splicing 10 10 10 26.6 26.6 26.6 46.898 3.6235E-145 263380000 137900000 125480000 2757 IPI:IPI00103654.2;IPI:IPI00856016.1;IPI:IPI00746062.1 Serine/threonine-protein phosphatase 4 regulatory subunit 2 PPP4R2;SBBI57 Q9NY27-1;Q9NY27;Q9NY27-3;Q9NY27-2 ENST00000295862;ENST00000356692;ENST00000394284 3 NaN 1.9162 NaN NaN 1.2474 NaN FYVE cell part;cytoplasmic part;endoplasmic reticulum;Golgi apparatus part;Golgi stack;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;organelle;organelle part binding;cation binding;ion binding;lipid binding;metal ion binding;phosphatidylinositol binding;phosphatidylinositol-3,4,5-trisphosphate binding;phosphatidylinositol-3,4-bisphosphate binding;phosphoinositide binding;phospholipid binding;zinc ion binding 3 3 3 4.9 4.9 4.9 87.175 4.2491E-25 2196500 1366700 829840 2758 IPI:IPI00103874.7;IPI:IPI00186917.3 Zinc finger FYVE domain-containing protein 1;Double FYVE-containing protein 1;Tandem FYVE fingers-1;SR3 ZFYVE1;DFCP1;KIAA1589;TAFF1;ZNFN2A1;PP10436 Q9HBF4-1;Q9HBF4 ENST00000318876;ENST00000394207 2 0.83502 1.4487 0.66215 1.0498 1.0268 0.84564 FSH1 cell part;cytoplasm;intracellular part catalytic activity;hydrolase activity response to chemical stimulus;response to external stimulus;response to extracellular stimulus;response to nutrient;response to nutrient levels;response to retinoic acid;response to stimulus;response to vitamin;response to vitamin A 5 5 5 30.4 30.4 30.4 24.418 1.1117E-126 29844000 16543000 13301000 2759 IPI:IPI00103884.3 Ovarian cancer-associated gene 2 protein OVCA2 Q8WZ82 ENST00000263084 1 0.81668 1.5361 0.79294 1.0513 1.0753 0.9636 binding;protein binding 7 7 7 13.3 13.3 13.3 62.717 3.0615E-25 105400000 55226000 50177000 2760 IPI:IPI00103925.2 Immunity-related GTPase family Q protein IRGQ;IRGQ1;FKSG27 Q8WZA9 ENST00000300809 1 0.73132 1.3808 0.72569 0.95305 0.90027 0.95171 Anticodon_1;tRNA-synt_1g cell part;cytoplasm;intracellular part aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;leucine-tRNA ligase activity;ligase activity;ligase activity, forming carbon-oxygen bonds;nucleoside binding;nucleotide binding;purine nucleoside binding cellular amino acid and derivative metabolic process;leucyl-tRNA aminoacylation;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;tRNA aminoacylation for protein translation;tRNA metabolic process Aminoacyl-tRNA biosynthesis;Valine, leucine and isoleucine biosynthesis 51 51 51 48.5 48.5 48.5 134.46 0 3249400000 1810900000 1438500000 2761 IPI:IPI00103994.4 Leucyl-tRNA synthetase, cytoplasmic;Leucine--tRNA ligase LARS;KIAA1352 Q9P2J5 ENST00000394434 K01869 1 0.67755 1.5055 0.76573 0.99798 0.97013 1.0698 cell part;intracellular organelle part;intracellular part;macromolecular complex;mediator complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;nucleoside binding;nucleotide binding;purine nucleoside binding;receptor activity;receptor binding;RNA polymerase II transcription factor activity;signal transducer activity;transcription coactivator activity;transcription cofactor activity cell communication;intracellular signaling cascade;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;signal transduction;transcription initiation;transcription initiation from RNA polymerase II promoter 17 17 17 18.6 18.6 18.6 108.66 1.1567E-279 1106200000 583590000 522570000 2762 IPI:IPI00104050.3 Thyroid hormone receptor-associated protein 3;Thyroid hormone receptor-associated protein complex 150 kDa component THRAP3;TRAP150 Q9Y2W1 ENST00000354618 1 0.77385 1.5876 0.85561 0.95687 1.1376 1.0347 Peptidase_S24 cell fraction;endoplasmic reticulum membrane;insoluble fraction;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane fraction;membrane part;microsome;organelle membrane;organelle part;vesicular fraction binding;catalytic activity;hydrolase activity;peptidase activity;protein binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;peptide metabolic process;protein catabolic process;protein metabolic process;protein processing;proteolysis;signal peptide processing Protein export 4 4 4 19.6 19.6 19.6 20.625 3.9263E-11 139730000 73885000 65842000 2763 IPI:IPI00104128.3 Signal peptidase complex catalytic subunit SEC11A;SEC11 homolog A;SEC11-like protein 1;Microsomal signal peptidase 18 kDa subunit;SPC18;Endopeptidase SP18 SEC11A;SEC11L1;SPC18;SPCS4A P67812 ENST00000268220 K03100 1 0.85161 1.6601 0.85435 1.1288 1.0779 1.1097 PCI cell part;cytoplasmic part;cytosol;intracellular part;macromolecular complex;proteasome complex;protein complex binding;protein binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Proteasome 33 33 33 63.8 63.8 63.8 47.534 0 3274600000 1720500000 1554100000 2764 IPI:IPI00105598.3 26S proteasome non-ATPase regulatory subunit 11;26S proteasome regulatory subunit S9;26S proteasome regulatory subunit p44.5 PSMD11 O00231 ENST00000261712 K03036 1 0.76207 1.3879 0.89186 0.94434 0.98726 1.1079 Gtr1_RagA cell part;cytoplasmic part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;identical protein binding;nucleotide binding;protein binding;protein homodimerization activity;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding apoptosis;biological regulation;cell communication;cell death;cell surface receptor linked signal transduction;cellular process;regulation of biological process;regulation of cell death;regulation of cellular process;signal transduction 5 5 5 13 13 13 40.172 3.66E-24 38360000 20755000 17605000 2765 IPI:IPI00296554.1;IPI:IPI00105620.2;IPI:IPI00010317.4 Ras-related GTP-binding protein B;Ras-related GTP-binding protein A;Adenovirus E3 14.7 kDa-interacting protein 1;FIP-1 RRAGB;RRAGA Q5VZM2-2;Q5VZM2;Q7L523;Q5VZM2-1 ENST00000262850;ENST00000374941;ENST00000380527 3 NaN NaN 0.65899 NaN NaN 0.8588 DIE2_ALG10 cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part;plasma membrane catalytic activity;transferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring hexosyl groups N-Glycan biosynthesis 2 2 2 5.9 5.9 5.9 55.605 1.6696E-06 16752000 8655800 8096000 2766 IPI:IPI00414597.4;IPI:IPI00105827.4 Alpha-1,2-glucosyltransferase ALG10-A;Alpha-2-glucosyltransferase ALG10-A;Asparagine-linked glycosylation protein 10 homolog A;Putative alpha-1,2-glucosyltransferase ALG10-B;Asparagine-linked glycosylation protein 10 homolog B;Potassium channel regulator 1 ALG10;ALG10A;ALG10B;KCR1 Q5BKT4;Q5I7T1 ENST00000266483;ENST00000308742 K03850 2 0.57869 1.2997 0.63 0.81058 0.82761 0.86028 Ribosomal_L10 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part cellular component biogenesis;cellular process;ribonucleoprotein complex biogenesis;ribosome biogenesis 15 15 15 52.7 52.7 52.7 27.56 4.0285E-88 1192000000 649700000 542280000 2767 IPI:IPI00106491.3 mRNA turnover protein 4 homolog MRTO4;C1orf33;MRT4 Q9UKD2 ENST00000330263 1 0.66905 1.1637 0.67334 0.87616 0.7708 0.86624 chromosomal part;condensin complex;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;organelle part;protein complex binding;protein binding cell cycle process;cell division;cellular component organization;cellular process;chromosome condensation;chromosome organization;DNA packaging;mitotic chromosome condensation;organelle organization Cell cycle - yeast 24 24 24 28.4 28.4 28.4 114.33 0 522730000 280500000 242230000 2768 IPI:IPI00106495.1 Condensin complex subunit 3;Non-SMC condensin I complex subunit G;Chromosome-associated protein G;Condensin subunit CAP-G;XCAP-G homolog;Antigen NY-MEL-3 NCAPG;CAPG;NYMEL3 Q9BPX3 ENST00000251496 K06678 1 NaN 1.3974 NaN NaN 0.94808 NaN BACK;BTB;Kelch_1 centrosome;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;microtubule organizing center;non-membrane-bounded organelle;nucleus;organelle;organelle part biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription Ubiquitin mediated proteolysis 4 4 4 6.2 6.2 6.2 69.666 8.8424E-05 7078600 4288800 2789800 2769 IPI:IPI00106502.5 Kelch-like ECH-associated protein 1;Cytosolic inhibitor of Nrf2;Kelch-like protein 19 KEAP1;INRF2;KIAA0132;KLHL19 Q14145 ENST00000171111;ENST00000393623 K10456 1 0.82601 4.3405 0.8652 1.1019 2.7859 1.1566 CALCOCO1 cell part;intracellular binding;cation binding;identical protein binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding anti-apoptosis;apoptosis;cell death;cellular process;death;negative regulation of apoptosis;negative regulation of programmed cell death;programmed cell death;regulation of apoptosis;regulation of cell death;regulation of programmed cell death 6 6 6 8.1 8.1 8.1 90.876 1.6968E-41 52071000 26757000 25314000 2772 IPI:IPI00657950.1;IPI:IPI00106559.3;IPI:IPI00747530.1 Tax1-binding protein 1;TRAF6-binding protein TAX1BP1;T6BP;PRO0105 Q86VP1-1;Q86VP1;Q86VP1-2;Q86VP1-3 ENST00000396319;ENST00000409980 3 0.58904 1.0154 0.56722 0.74367 0.73075 0.69808 Collagen;WD40 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding DNA metabolic process;DNA repair;gamete generation;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;postreplication repair;response to DNA damage stimulus;response to stress;spermatogenesis 5 5 5 5.2 5.2 5.2 145.89 5.8961E-13 28722000 16073000 12649000 2773 IPI:IPI00106567.2 WD repeat-containing protein 33;WD repeat-containing protein WDC146 WDR33;WDC146 Q9C0J8 ENST00000322313 1 0.64585 1.6838 NaN 0.86856 1.0788 NaN Methyltransf_11 cell part;cytoplasmic part;intracellular organelle part;intracellular part;membrane;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part catalytic activity;methyltransferase activity;transferase activity;transferase activity, transferring one-carbon groups metabolic process 4 4 4 12.5 12.5 12.5 38.918 1.8272E-28 4888200 2872900 2015300 2774 IPI:IPI00106573.6;IPI:IPI00644146.1 Probable methyltransferase C20orf7, mitochondrial C20orf7 Q5TEU4-1;Q5TEU4;Q5TEU4-2 ENST00000378081;ENST00000378106 2 0.95444 2.2802 0.90092 1.2645 1.4947 1.1791 MIR endoplasmic reticulum;endoplasmic reticulum lumen;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;membrane-enclosed lumen;organelle;organelle lumen;organelle part 18 3 3 43.5 8.2 8.2 67.017 0 74721000 38450000 36270000 2775 IPI:IPI00106642.4;IPI:IPI00414123.4;IPI:IPI00872788.1 Stromal cell-derived factor 2-like protein 1;PWP1-interacting protein 8 SDF2L1;UNQ1941/PRO4424 Q9HCN8 ENST00000248958 3 0.97279 1.5981 0.87213 1.3043 1.0016 1.1837 cell fraction;endosome;Golgi lumen;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;late endosome;membrane-bounded organelle;membrane-enclosed lumen;organelle;organelle lumen;organelle part;soluble fraction binding;calcium ion binding;cation binding;ion binding;metal ion binding cell differentiation;cellular process;cerebellum development;developmental process;response to abiotic stimulus;response to chemical stimulus;response to light stimulus;response to organic substance;response to radiation;response to UV;UV protection 4 4 4 14.1 14.1 14.1 41.806 7.7408E-11 48855000 24298000 24557000 2776 IPI:IPI00106646.1;IPI:IPI00009794.1;IPI:IPI00930668.1;IPI:IPI00930709.1;IPI:IPI00930387.1 45 kDa calcium-binding protein;Cab45;Stromal cell-derived factor 4 SDF4;CAB45;PSEC0034 Q9BRK5-1;Q9BRK5;Q9BRK5-4;Q9BRK5-3;Q9BRK5-2 ENST00000403997 5 0.68299 1.3849 0.69201 0.86402 0.89545 0.89144 eRF1_1;eRF1_2;eRF1_3 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;cation binding;endonuclease activity;hydrolase activity;hydrolase activity, acting on ester bonds;ion binding;metal ion binding;nuclease activity;protein binding biosynthetic process;cell cycle;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 11 11 10 27.3 27.3 27.3 43.377 5.3857E-61 124180000 67919000 56261000 2777 IPI:IPI00106698.1 Protein pelota homolog PELO;CGI-17 Q9BRX2 ENST00000274311;ENST00000381463 K06965 1 0.66693 1.7568 0.82039 0.8786 1.2167 1.0146 adh_short cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;microbody;mitochondrion;organelle;peroxisome binding;carbonyl reductase (NADPH) activity;catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor metabolic process;oxidation reduction Retinol metabolism 4 4 4 14.4 14.4 14.4 29.537 2.9612E-11 170950000 95059000 75895000 2779 IPI:IPI00106913.4;IPI:IPI00885050.1;IPI:IPI00152403.2;IPI:IPI00719360.3;IPI:IPI00454647.2;IPI:IPI00376623.2 Dehydrogenase/reductase SDR family member 4;Short-chain dehydrogenase/reductase family member 4;NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase;Peroxisomal short-chain alcohol dehydrogenase;NADPH-dependent retinol dehydrogenase/reductase;SCAD-SRL DHRS4;UNQ851/PRO1800 Q9BTZ2-1;Q9BTZ2;Q9BTZ2-4 ENST00000313250;ENST00000382761;ENST00000397073;ENST00000397074;ENST00000397075 K11147 6 1.5231 3.0461 1.3545 2.0882 1.9801 1.8457 4 4 4 12.9 12.9 12.9 41.036 8.678E-19 35626000 16011000 19615000 2780 IPI:IPI00106955.3 Uncharacterized protein C11orf84 C11orf84 Q9BUA3 ENST00000294244 1 0.60418 1.2529 0.56024 0.81221 0.86259 0.74187 DUF1301 integral to membrane;integral to mitochondrial membrane;integral to organelle membrane;intracellular part;intrinsic to membrane;intrinsic to organelle membrane;membrane;membrane part;mitochondrial membrane;organelle membrane;organelle part anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;mitochondrial proton-transporting ATP synthase complex assembly;protein complex assembly 4 4 4 19.2 19.2 19.2 28.969 5.4003E-09 33634000 20350000 13284000 2781 IPI:IPI00106966.4;IPI:IPI00787239.1 Transmembrane protein 70, mitochondrial TMEM70 Q9BUB7-1;Q9BUB7;Q9BUB7-2 ENST00000312184 2 0.94781 1.7883 0.7296 1.1828 1.1301 0.94016 SWIB cell part;chromatin remodeling complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex;SWI/SNF complex;SWI/SNF-type complex binding;nuclear hormone receptor binding;protein binding;receptor binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding;transcription regulator activity chromatin organization;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 7 2 2 16.4 5.3 5.3 53.687 2.8864E-30 26359000 14408000 11951000 2782 IPI:IPI00106988.1;IPI:IPI00456146.1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3;60 kDa BRG-1/Brm-associated factor subunit C;BRG1-associated factor 60C SMARCD3;BAF60C Q6STE5-2;Q6STE5;Q6STE5-1 ENST00000262188;ENST00000356800;ENST00000392811 K11650 2 0.45439 0.83091 0.40132 0.63163 0.5225 0.56569 Utp14 intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;preribosome;ribonucleoprotein complex;small-subunit processome binding;protein binding cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 16 16 16 25.2 25.2 25.2 87.977 9.5154E-154 125480000 69112000 56368000 2783 IPI:IPI00107113.3;IPI:IPI00940505.1;IPI:IPI00550793.3 U3 small nucleolar RNA-associated protein 14 homolog A;Serologically defined colon cancer antigen 16;Antigen NY-CO-16 UTP14A;SDCCAG16 Q9BVJ6-1;Q9BVJ6;Q9BVJ6-2 ENST00000371042;ENST00000371051;ENST00000394422 3 NaN 1.5105 0.61253 NaN 0.90714 0.8789 cell part;intracellular organelle part;intracellular part;macromolecular complex;membrane;membrane part;nuclear membrane;nuclear part;nuclear pore;organelle membrane;organelle part;pore complex;protein complex cellular process;establishment of protein localization;intracellular protein transport;intracellular transport;mRNA transport;nucleic acid transport;nucleobase, nucleoside, nucleotide and nucleic acid transport;protein transport;RNA transport;transport 4 4 4 8.8 8.8 8.8 60.896 1.1225E-70 15845000 8542300 7302600 2784 IPI:IPI00107122.1;IPI:IPI00938163.1 Nucleoporin p58/p45;Nucleoporin-like 1 NUPL1;KIAA0410 Q9BVL2-1;Q9BVL2;Q9BVL2-2 ENST00000381736 2 0.881 1.8418 NaN 1.1792 1.2464 NaN MMR_HSR1 cell part;intracellular binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding 3 3 3 11.3 11.3 11.3 32.146 2.1949E-11 1942400 1145300 797070 2785 IPI:IPI00107246.4;IPI:IPI00292183.2;IPI:IPI00514066.4 GTP-binding protein 8 GTPBP8 Q8N3Z3-1;Q8N3Z3;Q8N3Z3-2;Q8N3Z3-3 ENST00000295864;ENST00000305485;ENST00000383677;ENST00000383678 3 0.7757 1.4396 0.7967 0.97461 0.98767 0.99985 WD40 cell part;internal side of plasma membrane;membrane part;plasma membrane part cell communication;cell surface receptor linked signal transduction;cellular process;G-protein coupled receptor protein signaling pathway;intracellular signaling cascade;regulation of biological process;regulation of cellular process;signal transduction 4 4 4 11.3 11.3 11.3 35.618 1.3655E-41 16624000 8507900 8116100 2786 IPI:IPI00107339.4;IPI:IPI00218734.1 Guanine nucleotide-binding protein subunit beta-like protein 1;WD40 repeat-containing protein deleted in VCFS;WD repeat-containing protein 14;DGCRK3 GNB1L;GY2;KIAA1645;WDR14;FKSG1 Q9BYB4-1;Q9BYB4;Q9BYB4-2 ENST00000329517;ENST00000403325 2 0.91651 1.436 0.98376 1.1849 1.0152 1.2703 CLPTM1 cell part;external side of plasma membrane;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part cell differentiation;cellular process;developmental process;multicellular organismal development;multicellular organismal process;regulation of immune system process;regulation of leukocyte activation;regulation of T cell differentiation in the thymus 5 5 5 9.3 9.3 9.3 77.958 0 256080000 87833000 168240000 2787 IPI:IPI00107357.7;IPI:IPI00396411.4 Cleft lip and palate transmembrane protein 1 CLPTM1 O96005-2;O96005;O96005-1 ENST00000337392;ENST00000347493 2 1.4209 1.3208 0.64102 1.79 0.8435 0.88548 Rad50_zn_hook;SMC_N cell part;chromosomal part;chromosome, telomeric region;intracellular organelle part;intracellular part;macromolecular complex;Mre11 complex;nuclear chromosome part;nuclear chromosome, telomeric region;nuclear part;organelle part;protein complex ATP binding;binding;catalytic activity;DNA binding;hydrolase activity;hydrolase activity, acting on ester bonds;nuclease activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;zinc ion binding DNA metabolic process;DNA repair;DNA replication;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of DNA recombination;regulation of mitotic recombination;RNA-dependent DNA replication;telomere maintenance Homologous recombination;Non-homologous end-joining 8 8 8 6.4 6.4 6.4 154.59 1.5775E-70 39035000 22231000 16805000 2788 IPI:IPI00549205.1;IPI:IPI00305282.2;IPI:IPI00107531.1 DNA repair protein RAD50 RAD50 Q92878-2;Q92878;Q92878-1;Q92878-3 ENST00000265335;ENST00000378823 K10866 3 0.78947 1.9063 0.75184 0.94158 1.3464 0.93472 ARC105_Med_act cytoplasmic part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;mediator complex;membrane-bounded organelle;nuclear part;organelle;organelle part;protein complex binding;general RNA polymerase II transcription factor activity;protein binding;RNA polymerase II transcription factor activity;RNA polymerase II transcription mediator activity;transcription regulator activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 3 3 3 5.3 5.3 5.3 86.753 8.0069E-12 47197000 24217000 22979000 2789 IPI:IPI00107693.4;IPI:IPI00220307.5;IPI:IPI00554734.1 Mediator of RNA polymerase II transcription subunit 15;Mediator complex subunit 15;Positive cofactor 2 glutamine/Q-rich-associated protein;TPA-inducible gene 1 protein;Activator-recruited cofactor 105 kDa component;CTG repeat protein 7a;Trinucleotide repeat-containing gene 7 protein MED15;ARC105;CTG7A;PCQAP;TIG1;TNRC7 Q96RN5-1;Q96RN5;Q96RN5-2;Q96RN5-3 ENST00000263205;ENST00000292733;ENST00000382974 3 0.67291 1.0335 0.63696 0.8277 0.69908 0.81173 Glyoxalase cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle catalytic activity;isomerase activity;methylmalonyl-CoA epimerase activity;racemase and epimerase activity cellular metabolic process;cellular process;coenzyme metabolic process;cofactor metabolic process;L-methylmalonyl-CoA metabolic process;metabolic process Propanoate metabolism;Valine, leucine and isoleucine degradation 3 3 3 18.2 18.2 18.2 18.749 1.9644E-06 34241000 17992000 16249000 2791 IPI:IPI00107722.6 Methylmalonyl-CoA epimerase, mitochondrial;DL-methylmalonyl-CoA racemase MCEE Q96PE7 ENST00000244217 K05606 1 0.7008 1.3739 0.63789 0.88255 0.91723 0.82503 LUC7 cell part;intracellular organelle part;intracellular part;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part binding;DNA binding;mRNA binding;nucleic acid binding;protein binding;RNA binding apoptosis;cell death;cellular process;metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;programmed cell death;response to stress;RNA processing;RNA splicing 9 9 9 20.6 20.6 20.6 51.466 0 542100000 283900000 258200000 2792 IPI:IPI00107745.3;IPI:IPI00448519.1 Cisplatin resistance-associated overexpressed protein;cAMP regulatory element-associated protein 1;Luc7A;Okadaic acid-inducible phosphoprotein OA48-18 CROP;CREAP1;O48 O95232-1;O95232 ENST00000240304;ENST00000311571;ENST00000393227 2 0.43383 1.2499 NaN 0.59004 0.84749 NaN dDENN;DENN;uDENN cell part;cytoplasm;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;plasma membrane binding;cytokine receptor binding;death receptor binding;enzyme activator activity;guanyl-nucleotide exchange factor activity;protein binding;Ras guanyl-nucleotide exchange factor activity;receptor binding;small GTPase regulator activity activation of MAPK activity;apoptosis;cell communication;cell surface receptor linked signal transduction;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;signal transduction 2 2 2 1.2 1.2 1.2 178.56 6.7025E-06 3589300 2116700 1472600 2793 IPI:IPI00292095.7;IPI:IPI00107844.5;IPI:IPI00292094.4;IPI:IPI00237706.4;IPI:IPI00788877.2;IPI:IPI00103536.4;IPI:IPI00107843.6 MAP kinase-activating death domain protein;Differentially expressed in normal and neoplastic cells;Insulinoma glucagonoma clone 20;Rab3 GDP/GTP exchange factor MADD;DENN;IG20;KIAA0358 Q8WXG6-2;Q8WXG6;Q8WXG6-3;Q8WXG6-4;Q8WXG6-5;Q8WXG6-6;Q8WXG6-1;Q8WXG6-7 ENST00000311027;ENST00000349238;ENST00000395336;ENST00000395342;ENST00000395349 7 0.72378 1.1378 NaN 0.9784 0.74985 NaN adh_short;WW cell part;cytoplasmic part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;nucleus;organelle binding;catalytic activity;coenzyme binding;cofactor binding;oxidoreductase activity;protein binding;protein dimerization activity biosynthetic process;cell cycle;cellular biosynthetic process;cellular lipid metabolic process;cellular metabolic process;cellular process;lipid metabolic process;metabolic process;primary metabolic process;steroid metabolic process 3 3 3 9.4 9.4 9.4 46.676 6.0646E-05 4029100 2286000 1743100 2794 IPI:IPI00299802.2;IPI:IPI00107869.2 WW domain-containing oxidoreductase;Fragile site FRA16D oxidoreductase WWOX;FOR;WOX1 Q9NZC7-1;Q9NZC7;Q9NZC7-2 ENST00000329729;ENST00000355860;ENST00000402655;ENST00000402759;ENST00000406884;ENST00000408984 2 3.2934 0.79659 NaN 4.1396 0.54696 NaN Dor1 cell part;cytoplasmic part;Golgi apparatus part;Golgi membrane;Golgi transport complex;intracellular organelle part;intracellular part;macromolecular complex;membrane;organelle membrane;organelle part;protein complex establishment of localization;establishment of protein localization;protein transport;transport 3 3 3 5.9 5.9 5.9 71.208 4.1925E-63 2491700 968250 1523500 2795 IPI:IPI00140201.4 Conserved oligomeric Golgi complex subunit 8;Component of oligomeric Golgi complex 8 COG8 Q96MW5 ENST00000306875;ENST00000401849 1 0.74334 1.2646 0.72438 0.94249 0.85219 0.93199 SNase;TUDOR cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;Golgi apparatus;macromolecular complex;melanosome;membrane-bounded vesicle;nucleus;organelle;ribonucleoprotein complex;RNAi effector complex;RNA-induced silencing complex;vesicle binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;nuclease activity;nucleic acid binding;protein binding;transcription cofactor activity;transcription factor binding;transcription regulator activity biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 44 44 44 61 61 61 102 0 4489000000 2373200000 2115800000 2796 IPI:IPI00140420.4 Staphylococcal nuclease domain-containing protein 1;p100 co-activator;100 kDa coactivator;EBNA2 coactivator p100;Tudor domain-containing protein 11 SND1;TDRD11 Q7KZF4 ENST00000354725 1 NaN NaN 0.64086 NaN NaN 0.94925 cell fraction;cell part;cytoplasmic part;ER-Golgi intermediate compartment membrane;insoluble fraction;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane fraction;membrane part;organelle membrane;organelle part 4 4 4 9 9 9 66.022 2.6246E-21 9871200 5158400 4712800 2797 IPI:IPI00141318.2;IPI:IPI00604713.3 Cytoskeleton-associated protein 4;63 kDa membrane protein;p63 CKAP4 Q07065-1;Q07065;Q07065-2 ENST00000258512;ENST00000378026 2 1.2949 1.7899 0.8634 1.6167 1.2434 1.0843 Vps51 cell part;cytoplasmic part;Golgi apparatus part;Golgi membrane;Golgi transport complex;intracellular organelle part;intracellular part;macromolecular complex;membrane;organelle membrane;organelle part;protein complex binding;protein binding cellular component organization;cellular process;establishment of protein localization;Golgi organization;intracellular transport;intra-Golgi vesicle-mediated transport;organelle organization;protein transport;transport;vesicle-mediated transport 9 9 9 11 11 11 108.98 3.5862E-30 23410000 11347000 12063000 2798 IPI:IPI00141561.3 Conserved oligomeric Golgi complex subunit 1;Component of oligomeric Golgi complex 1 COG1;KIAA1381;LDLB Q8WTW3 ENST00000299886 1 0.63561 1.3535 0.69789 0.85146 0.94736 0.87589 Sec1 cellular process;establishment of localization;establishment of protein localization;membrane docking;protein transport;transport;vesicle docking;vesicle docking during exocytosis 10 10 10 17.5 17.5 17.5 75.126 4.2153E-113 115090000 60737000 54358000 2799 IPI:IPI00419891.3;IPI:IPI00141564.8 Sec1 family domain-containing protein 2;Syntaxin-binding protein 1-like 1 SCFD2;STXBP1L1 Q8WU76-1;Q8WU76;Q8WU76-2 ENST00000388940;ENST00000401642 2 0.84871 1.5745 0.85874 1.1287 1.0642 1.128 Mad3_BUB1_I anaphase-promoting complex;cell part;cytoplasmic part;cytoskeletal part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nuclear ubiquitin ligase complex;organelle part;protein complex;ubiquitin ligase complex ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity apoptosis;cell cycle checkpoint;cytoskeleton organization;microtubule cytoskeleton organization;microtubule-based process;mitotic cell cycle checkpoint;organelle organization;proteolysis;spindle organization;ubiquitin-dependent protein catabolic process Cell cycle 10 10 10 10.6 10.6 10.6 121.38 1.3971E-65 35495000 17109000 18386000 2800 IPI:IPI00921844.1;IPI:IPI00141933.3;IPI:IPI00922915.1 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta;MAD3/BUB1-related protein kinase;Mitotic checkpoint kinase MAD3L;Protein SSK1 BUB1B;BUBR1;MAD3L;SSK1 O60566-3;O60566;O60566-1;O60566-2 ENST00000287598 K06637 3 0.83859 1.0911 0.61604 1.0252 0.73959 0.80325 cell part;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;nucleoplasm;organelle;organelle part ATP binding;binding;catalytic activity;DNA binding;DNA helicase activity;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity DNA metabolic process;DNA repair;double-strand break repair;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to DNA damage stimulus;response to stress;RNA processing 3 3 3 1.1 1.1 1.1 306.44 0.00040922 277210000 125800000 151410000 2801 IPI:IPI00646645.3;IPI:IPI00719643.3;IPI:IPI00142538.4 Probable helicase senataxin;SEN1 homolog;Amyotrophic lateral sclerosis 4 protein SETX;ALS4;KIAA0625;SCAR1 Q7Z333-4;Q7Z333;Q7Z333-3;Q7Z333-1 ENST00000224140;ENST00000393220 K10706 3 0.69889 1.4183 0.74244 0.92881 0.94736 0.95894 RRM_1;Surp binding;nucleic acid binding;nucleotide binding;RNA binding cellular biopolymer metabolic process;cellular process;macromolecule metabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing 24 24 24 29.3 29.3 29.3 118.29 0 689120000 370770000 318350000 2802 IPI:IPI00143753.6;IPI:IPI00829908.1;IPI:IPI00790699.3 U2-associated protein SR140;140 kDa Ser/Arg-rich domain protein SR140;KIAA0332 O15042-1;O15042;O15042-2;O15042-3 ENST00000319822;ENST00000397933 3 0.6936 1.6736 0.86641 0.98109 1.1047 1.1974 YTH cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 5 5 5 7.4 7.4 7.4 84.699 7.401E-18 78890000 41024000 37866000 2803 IPI:IPI00144293.4;IPI:IPI00376222.1 YTH domain-containing protein 1;Putative splicing factor YT521 YTHDC1;KIAA1966;YT521 Q96MU7-1;Q96MU7;Q96MU7-2 ENST00000344157;ENST00000355665 2 0.8038 NaN 0.74022 0.96252 NaN 0.89815 GCV_T;GCV_T_C cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle aminomethyltransferase activity;catalytic activity;methyltransferase activity;transferase activity;transferase activity, transferring one-carbon groups catabolic process;cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;glycine catabolic process;glycine metabolic process;metabolic process;nitrogen compound metabolic process;organic acid metabolic process 3 3 3 10.1 10.1 10.1 38.155 1.5106E-05 20228000 10321000 9906600 2804 IPI:IPI00145260.3 Putative transferase C1orf69, mitochondrial C1orf69 Q5T440 ENST00000366711 K06980 1 0.48417 NaN 0.49177 0.67692 NaN 0.70578 MA3;MIF4G cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;protein binding cellular biopolymer metabolic process;cellular process;macromolecule metabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process 5 5 5 8.1 8.1 8.1 96.256 6.1335E-37 21911000 13156000 8754500 2805 IPI:IPI00145593.7 Nucleolar MIF4G domain-containing protein 1;SGD1 homolog NOM1;C7orf3 Q5C9Z4 ENST00000275820 1 0.7162 1.1581 NaN 0.88874 0.81774 NaN CNH;Pkinase ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;small GTPase regulator activity;transferase activity cell communication;intracellular signaling cascade;MAPKKK cascade;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein kinase cascade;protein modification process;response to stress;signal transduction 6 1 1 4.6 0.7 0.7 154.94 8.9084E-59 3608300 1557900 2050400 2806 IPI:IPI00145805.1;IPI:IPI00514275.3;IPI:IPI00218901.1;IPI:IPI00218905.4;IPI:IPI00218902.1;IPI:IPI00218906.4;IPI:IPI00218904.1;IPI:IPI00218907.1 TRAF2 and NCK-interacting protein kinase TNIK;KIAA0551 Q9UKE5-1;Q9UKE5;Q9UKE5-4;Q9UKE5-2;Q9UKE5-6;Q9UKE5-3;Q9UKE5-7;Q9UKE5-5;Q9UKE5-8 ENST00000284483;ENST00000341852;ENST00000357327 K08840 8 0.63345 1.2405 0.60125 0.85762 0.82373 0.79975 NeuB;SAF catalytic activity;N-acylneuraminate cytidylyltransferase activity;transferase activity;transferase activity, transferring alkyl or aryl (other than methyl) groups;transferase activity, transferring phosphorus-containing groups biosynthetic process;carbohydrate metabolic process;lipid biosynthetic process;lipid metabolic process;lipopolysaccharide metabolic process;metabolic process;polysaccharide biosynthetic process;polysaccharide metabolic process Aminosugars metabolism 9 9 9 34.5 34.5 34.5 40.307 7.0949E-114 244030000 133630000 110390000 2808 IPI:IPI00147874.1 Sialic acid synthase;N-acetylneuraminate synthase;N-acetylneuraminic acid synthase;N-acetylneuraminate-9-phosphate synthase;N-acetylneuraminic acid phosphate synthase NANS;SAS Q9NR45 ENST00000210444 K01654;K05304 1 0.78597 NaN 0.78191 0.97071 NaN 0.97119 Ldh_1_C;Ldh_1_N cell part;cytoplasm;intracellular part binding;catalytic activity;lactate dehydrogenase activity;L-lactate dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors alcohol metabolic process;carbohydrate metabolic process;catabolic process;cellular process;generation of precursor metabolites and energy;glucose catabolic process;glucose metabolic process;glycolysis;metabolic process;monosaccharide metabolic process Cysteine metabolism;Glycolysis / Gluconeogenesis;Propanoate metabolism;Pyruvate metabolism 3 1 1 6 1.8 1.8 36.507 1.1413E-70 23938000 15046000 8892000 2809 IPI:IPI00148061.3 L-lactate dehydrogenase A-like 6A LDHAL6A;LDHL2 Q6ZMR3 ENST00000280706;ENST00000396213 K00016 1 NaN 1.539 0.58911 NaN 0.94132 0.69867 SOUL circadian rhythm;rhythmic process 2 2 2 13.2 13.2 13.2 21.097 1.2403E-15 32166000 16116000 16049000 2810 IPI:IPI00148063.1 Heme-binding protein 1;p22HBP HEBP1;HBP Q9NRV9 ENST00000014930 1 NaN 1.8962 NaN NaN 1.1958 NaN PH actin cytoskeleton;cytoplasm;cytoskeleton;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle actin binding;binding;cytoskeletal protein binding;enzyme binding;GTPase binding;GTP-Rho binding;myosin binding;myosin II binding;protein binding;Ras GTPase binding;Rho GTPase binding;small GTPase binding cytoskeleton organization;metabolic process;negative regulation of metabolic process;organelle organization;protein modification process;regulation of actin polymerization or depolymerization;sensory perception;sensory perception of sound;system process 2 2 2 1 1 1 261.37 1.083E-05 596160 333810 262350 2811 IPI:IPI00413160.4;IPI:IPI00736522.1;IPI:IPI00741684.1;IPI:IPI00148768.4 TRIO and F-actin-binding protein;Protein Tara;Trio-associated repeat on actin TRIOBP;KIAA1662;TARA;HRIHFB2122 Q9H2D6-1;Q9H2D6;Q9H2D6-2;Q9H2D6-3;Q9H2D6-5 ENST00000344404;ENST00000396963;ENST00000396964;ENST00000406386 4 0.20729 0.5526 0.22933 0.28262 0.35947 0.30689 CNH;Pkinase basolateral plasma membrane;cell fraction;cell part;cytoplasmic part;Golgi apparatus part;Golgi membrane;intracellular organelle part;intracellular part;membrane;membrane part;organelle membrane;organelle part;plasma membrane part;soluble fraction ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;small GTPase regulator activity;transferase activity cell communication;immune response;immune system process;MAPKKK cascade;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;response to stress;signal transduction;vesicle targeting MAPK signaling pathway 3 3 3 3.8 3.8 3.8 91.555 4.1262E-06 15679000 9776700 5902500 2812 IPI:IPI00149094.4 Mitogen-activated protein kinase kinase kinase kinase 2;MAPK/ERK kinase kinase kinase 2;Germinal center kinase;Rab8-interacting protein;B lymphocyte serine/threonine-protein kinase MAP4K2;GCK;RAB8IP Q12851 ENST00000294066 K04414 1 0.88548 1.4165 0.82682 1.0788 1.0037 0.99789 BRE BRCA1-A complex;BRISC complex;cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nuclear ubiquitin ligase complex;organelle part;protein complex;ubiquitin ligase complex binding;cytokine receptor binding;peroxisome targeting sequence binding;polyubiquitin binding;protein binding;receptor binding;signal sequence binding;small conjugating protein binding;tumor necrosis factor receptor binding cell cycle checkpoint;chromatin organization;DNA damage checkpoint;DNA metabolic process;DNA repair;double-strand break repair;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of DNA repair 6 6 6 18.1 18.1 18.1 46.974 1.6834E-75 67068000 36018000 31050000 2813 IPI:IPI00149276.1;IPI:IPI00164724.1;IPI:IPI00719447.1;IPI:IPI00446802.8 BRCA1-A complex subunit BRE;Brain and reproductive organ-expressed protein;BRCA1/BRCA2-containing complex subunit 45 BRE;BRCC45 Q9NXR7-1;Q9NXR7;Q9NXR7-2;Q9NXR7-3;Q9NXR7-4 ENST00000342045;ENST00000344773;ENST00000379623;ENST00000379629 K12173 4 0.72825 1.0459 NaN 0.97728 0.69414 NaN RAI16-like 3 2 1 2.5 1.9 1 107.08 0.00022051 5044000 2591000 2453000 2814 IPI:IPI00149375.3;IPI:IPI00798104.2 UPF0518 protein FAM160A2;FTS and Hook-interacting protein FAM160A2;C11orf56;KIAA1759 Q8N612-2;Q8N612;Q8N612-1 ENST00000265978 2 0.44976 0.98593 0.50174 0.62136 0.65365 0.67411 Pro_isomerase;WD40 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex catalytic activity;cis-trans isomerase activity;isomerase activity;peptidyl-prolyl cis-trans isomerase activity cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein folding;RNA metabolic process;RNA processing;RNA splicing 12 12 11 19.2 19.2 18.3 73.574 1.6201E-42 112840000 63608000 49236000 2815 IPI:IPI00149650.3 Peptidylprolyl isomerase domain and WD repeat-containing protein 1 PPWD1;KIAA0073 Q96BP3 ENST00000261308 K01802 1 0.64346 1.3099 NaN 0.84321 0.83355 NaN Mic1 6 6 6 11.9 11.9 11.9 74.974 7.1244E-25 11308000 6439500 4868400 2816 IPI:IPI00149964.6 Uncharacterized protein C18orf8;Colon cancer-associated protein Mic1 C18orf8;MIC1 Q96DM3 ENST00000269221 1 0.82747 1.7547 0.93118 1.1054 1.1438 1.1481 Myb_DNA-binding;SWIRM cell part;chromatin;chromatin remodeling complex;chromosomal part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex;SWI/SNF complex;SWI/SNF-type complex binding;chromatin binding;DNA binding;nucleic acid binding;protein binding;protein C-terminus binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding chromatin assembly or disassembly;chromatin organization;chromatin remodeling;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 15 5 5 11.4 4.7 4.7 132.88 4.7955E-102 77915000 40541000 37375000 2817 IPI:IPI00216047.3;IPI:IPI00150057.6 SWI/SNF complex subunit SMARCC2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2;SWI/SNF complex 170 kDa subunit;BRG1-associated factor 170 SMARCC2;BAF170 Q8TAQ2-1;Q8TAQ2;Q8TAQ2-2 ENST00000267064;ENST00000347471 2 0.73813 1.5335 0.76652 1.0055 0.97725 1.0433 PRP4;WD40 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part;ribonucleoprotein complex;spliceosomal complex catalytic activity;RNA splicing factor activity, transesterification mechanism nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 20 20 20 42.3 42.3 42.3 58.449 1.009E-225 805290000 416720000 388570000 2818 IPI:IPI00150269.1;IPI:IPI00218435.1 U4/U6 small nuclear ribonucleoprotein Prp4;U4/U6 snRNP 60 kDa protein;WD splicing factor Prp4;PRP4 homolog PRPF4;PRP4 O43172-1;O43172;O43172-2 ENST00000374198 K08827 2 0.63127 1.3117 0.69102 0.83915 0.92271 0.89483 PseudoU_synth_2 binding;catalytic activity;intramolecular transferase activity;isomerase activity;nucleic acid binding;protein binding;pseudouridine synthase activity;RNA binding cellular biopolymer metabolic process;cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;pseudouridine synthesis;RNA metabolic process;RNA modification 7 7 7 15 15 15 61.311 1.2701E-31 113830000 62901000 50925000 2819 IPI:IPI00150963.3 RNA pseudouridylate synthase domain-containing protein 2 RPUSD2;C15orf19 Q8IZ73 ENST00000315616 1 0.67887 NaN 0.68457 0.927 NaN 0.8801 Pkinase cell part;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;organelle;organelle part;spindle ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;protein tyrosine kinase activity;purine nucleoside binding;transferase activity cell cycle checkpoint;microtubule cytoskeleton organization;positive regulation of protein amino acid phosphorylation;protein amino acid phosphorylation;protein modification process;regulation of protein amino acid phosphorylation Cell cycle - yeast 2 2 2 2.5 2.5 2.5 97.071 1.4688E-08 4327200 2327600 1999600 2820 IPI:IPI00151170.4 Dual specificity protein kinase TTK;Phosphotyrosine picked threonine-protein kinase TTK;MPS1L1 P33981 ENST00000230510 K08866 1 0.7064 1.5129 0.79846 1.0043 1.0235 1.0703 CLPTM1 cell part;integral to membrane;intrinsic to membrane;membrane part apoptosis;cell death;cellular process;death;programmed cell death 6 6 6 16.5 16.5 16.5 62.228 1.3116E-114 95776000 51233000 44543000 2821 IPI:IPI00151358.2;IPI:IPI00186429.8 Cleft lip and palate transmembrane protein 1-like protein;Cisplatin resistance-related protein 9;CRR9p CLPTM1L;CRR9 Q96KA5-1;Q96KA5;Q96KA5-2 ENST00000320895;ENST00000320927 2 1.2479 2.2702 1.2182 1.613 1.4481 1.5112 MAP1_LC3 autophagic vacuole membrane;cytoplasmic part;cytoplasmic vesicle;cytoskeletal part;endomembrane system;intracellular organelle;intracellular part;membrane;microtubule;organelle;organelle membrane;organelle part;vacuolar membrane;vacuolar part;vesicle binding;protein binding autophagy;catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 4 4 4 29.6 29.6 29.6 14.628 4.6108E-10 283270000 129460000 153810000 2822 IPI:IPI00151462.3;IPI:IPI00220482.8;IPI:IPI00015423.1;IPI:IPI00415014.3 Microtubule-associated proteins 1A/1B light chain 3 beta 2;Microtubule-associated proteins 1A/1B light chain 3B-like;Microtubule-associated proteins 1A/1B light chain 3B;Microtubule-associated protein 1 light chain 3 beta;MAP1A/1B light chain 3 B;MAP1A/MAP1B LC3 B;MAP1 light chain 3-like protein 2;Autophagy-related protein LC3 B;Autophagy-related ubiquitin-like modifier LC3 B MAP1LC3B2;MAP1LC3B;MAP1ALC3 A6NCE7;Q9GZQ8 ENST00000306985;ENST00000268607 K10435 4 NaN NaN 0.50395 NaN NaN 0.62607 WD40 cell part;extrinsic to membrane;extrinsic to plasma membrane;heterotrimeric G-protein complex;macromolecular complex;membrane part;plasma membrane part;protein complex catalytic activity;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;pyrophosphatase activity;signal transducer activity Chemokine signaling pathway 2 2 2 3.5 3.5 3.5 43.566 2.0393E-07 1212700 772800 439860 2823 IPI:IPI00151607.1;IPI:IPI00745232.1 Guanine nucleotide-binding protein subunit beta-5;Transducin beta chain 5;Gbeta5 GNB5 O14775-1;O14775;O14775-2 ENST00000261837;ENST00000358784 K04539 2 1.0656 1.6678 1.0544 1.3473 1.1982 1.3606 DUF590 cell part;integral to membrane;intrinsic to membrane;membrane part anion channel activity;anion transmembrane transporter activity;binding;calcium ion binding;channel activity;chloride channel activity;ion channel activity;ion transmembrane transporter activity;transporter activity establishment of localization;ion transport;transport 3 3 3 4.2 4.2 4.2 106.16 1.7085E-15 16286000 8147300 8138800 2824 IPI:IPI00151710.8 Anoctamin-6;Transmembrane protein 16F ANO6;TMEM16F Q4KMQ2 ENST00000320560 1 0.52968 0.90785 0.52953 0.65203 0.63457 0.64983 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 3 3 3 30.7 30.7 30.7 19.147 1.3442E-115 25712000 15204000 10508000 2826 IPI:IPI00152083.3 TTD non-photosensitive 1 protein TTDN1;C7orf11 Q8TAP9 ENST00000306984 1 0.83356 1.5747 0.92627 1.0272 1.019 1.2474 7 7 7 22.9 22.9 22.9 36.67 6.975E-22 86702000 45459000 41243000 2827 IPI:IPI00152089.3;IPI:IPI00552646.1;IPI:IPI00607830.1 Uncharacterized protein CXorf38 CXorf38 Q8TB03-1;Q8TB03;Q8TB03-3 ENST00000327877;ENST00000378418 3 0.59646 1.1564 0.47608 0.71458 0.83763 0.63258 Kelch_1;Kelch_2 5 5 5 14.4 14.4 14.4 57.891 1.1107E-17 31832000 16998000 14834000 2828 IPI:IPI00152182.1;IPI:IPI00642250.1;IPI:IPI00304958.2 Kelch domain-containing protein 4 KLHDC4 Q8TBB5-1;Q8TBB5;Q8TBB5-2;Q8TBB5-3 ENST00000270583;ENST00000347925;ENST00000353170 3 0.68267 1.1268 0.69965 0.89662 0.7225 0.90925 Hydrolase binding;catalytic activity;cation binding;hydrolase activity;hydrolase activity, acting on ester bonds;ion binding;magnesium ion binding;metal ion binding;phosphatase activity;phosphoglycolate phosphatase activity;phosphoric ester hydrolase activity alcohol metabolic process;amino sugar metabolic process;biosynthetic process;carbohydrate metabolic process;cellular process;metabolic process;monosaccharide metabolic process;N-acetylneuraminate metabolic process;organic acid metabolic process Aminosugars metabolism 5 5 5 25.8 25.8 25.8 27.813 3.8049E-17 58798000 32524000 26274000 2829 IPI:IPI00152196.3 N-acylneuraminate-9-phosphatase;Neu5Ac-9-Pase;Haloacid dehalogenase-like hydrolase domain-containing protein 4 NANP;C20orf147;HDHD4 Q8TBE9 ENST00000304788 K01097 1 NaN NaN 1.0072 NaN NaN 1.2463 DUF1242 cell part;integral to membrane;intrinsic to membrane;membrane part 2 2 2 25 25 25 8.0598 0.00015446 43321000 19223000 24098000 2830 IPI:IPI00152240.3 Transmembrane protein 167A TMEM167A;TMEM167 Q8TBQ9 ENST00000308489 1 NaN 0.74664 NaN NaN 0.44238 NaN WD40 2 1 1 5.4 3.6 3.6 53.667 0.0013556 563260 225710 337540 2831 IPI:IPI00152269.3 WD repeat-containing protein 51B WDR51B Q8TC44 ENST00000313546 1 0.83765 1.9563 NaN 1.0805 1.3472 NaN PIP5K cell part;cytoplasm;intracellular part;membrane ATP binding;binding;catalytic activity;inositol or phosphatidylinositol kinase activity;kinase activity;lipid kinase activity;nucleoside binding;nucleotide binding;phosphatidylinositol phosphate kinase activity;protein binding;purine nucleoside binding cellular metabolic process;cellular process;glycerophospholipid metabolic process;lipid metabolic process;metabolic process;organophosphate metabolic process;phosphoinositide metabolic process;phospholipid metabolic process;primary metabolic process Inositol phosphate metabolism;Phosphatidylinositol signaling system;Regulation of actin cytoskeleton 7 7 7 19.5 19.5 19.5 47.285 1.8924E-88 18558000 10338000 8220700 2832 IPI:IPI00152303.7 Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma;Phosphatidylinositol-5-phosphate 4-kinase type II gamma PIP4K2C;PIP5K2C Q8TBX8 ENST00000354947 K00920 1 NaN 1.7064 NaN NaN 1.1134 NaN tRNA_m1G_MT catalytic activity;methyltransferase activity;transferase activity;transferase activity, transferring one-carbon groups 4 4 4 16.8 16.8 16.8 39.718 5.8082E-08 5539200 2901700 2637500 2833 IPI:IPI00152325.2 RNA (guanine-9-)-methyltransferase domain-containing protein 2 RG9MTD2 Q8TBZ6 ENST00000273962;ENST00000394876;ENST00000394877 1 0.47773 0.94342 0.52224 0.61298 0.68054 0.69508 LRR_1 binding;protein binding 6 6 6 31.5 31.5 31.5 20.509 5.9868E-13 88403000 49512000 38891000 2834 IPI:IPI00152330.1;IPI:IPI00410486.2;IPI:IPI00018929.1 Leucine-rich repeat-containing protein 20 LRRC20;UNQ2429/PRO4989 Q8TCA0-1;Q8TCA0;Q8TCA0-2;Q8TCA0-3 ENST00000355790;ENST00000358141;ENST00000373224;ENST00000395010;ENST00000395011 3 0.79996 1.582 0.80912 1.0405 1.0915 1.0318 STT3 cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part binding;catalytic activity;dolichyl-diphosphooligosaccharide-protein glycotransferase activity;oligosaccharyl transferase activity;protein binding;transferase activity;transferase activity, transferring glycosyl groups biopolymer metabolic process;carbohydrate metabolic process;cellular biopolymer metabolic process;cellular process;macromolecule metabolic process;metabolic process;protein amino acid glycosylation;protein metabolic process;protein modification process N-Glycan biosynthesis 10 9 9 12.6 11.9 11.9 93.673 5.4453E-110 364890000 191770000 173130000 2835 IPI:IPI00152377.1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B;Source of immunodominant MHC-associated peptides homolog STT3B;SIMP Q8TCJ2 ENST00000295770 K00730 1 0.69093 1.6317 NaN 0.9486 1.0708 NaN 3 3 3 14.3 14.3 14.3 37.048 1.082E-08 22476000 12148000 10328000 2836 IPI:IPI00152407.3;IPI:IPI00059687.1 Uncharacterized protein C18orf25 C18orf25 Q96B23-2;Q96B23;Q96B23-1 ENST00000282059;ENST00000321319 2 0.76639 1.4455 0.56919 1.0515 0.95908 0.74812 Aminotran_1_2 binding;catalytic activity;L-alanine:2-oxoglutarate aminotransferase activity;lipid binding;pyridoxal phosphate binding;steroid binding;transaminase activity;transferase activity;transferase activity, transferring nitrogenous groups;vitamin binding biosynthetic process;metabolic process Alanine and aspartate metabolism;Carbon fixation in photosynthetic organisms;Glutamate metabolism 8 8 8 20.1 20.1 20.1 57.903 6.0758E-82 16022000 8987400 7035000 2837 IPI:IPI00152432.2;IPI:IPI00784445.1 Alanine aminotransferase 2;Glutamic--pyruvic transaminase 2;Glutamate pyruvate transaminase 2;Glutamic--alanine transaminase 2 GPT2;AAT2;ALT2 Q8TD30-1;Q8TD30;Q8TD30-2 ENST00000340124 K00814 2 0.78108 1.66 0.79352 1.0137 1.0268 0.99498 Peptidase_A22B cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part aspartic-type endopeptidase activity;aspartic-type peptidase activity;binding;catalytic activity;endopeptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides;protein binding 5 5 5 14.6 14.6 14.6 41.488 4.0669E-102 180140000 96468000 83672000 2838 IPI:IPI00152441.3;IPI:IPI00552772.2;IPI:IPI00220687.1;IPI:IPI00329296.1 Minor histocompatibility antigen H13;Signal peptide peptidase;Presenilin-like protein 3;Protein hIMP1 HM13;H13;IMP1;PSL3;SPP;MSTP086 Q8TCT9-1;Q8TCT9;Q8TCT9-5;Q8TCT9-2;Q8TCT9-4 ENST00000335574;ENST00000340852;ENST00000344042;ENST00000376127;ENST00000398164;ENST00000398174 K09595 4 0.27629 0.74428 NaN 0.34026 0.50213 NaN WD40 cell junction;clathrin coated vesicle membrane;coated vesicle membrane;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;cytoplasmic vesicle membrane;membrane;organelle membrane;secretory granule;synaptic vesicle membrane;vesicle;vesicle membrane binding;enzyme binding;enzyme regulator activity;GTPase binding;GTPase regulator activity;nucleoside-triphosphatase regulator activity;protein binding;Rab GTPase binding;Ras GTPase binding;small GTPase binding;small GTPase regulator activity 4 4 4 1.7 1.7 1.7 339.71 4.7559E-14 6057200 3081400 2975800 2840 IPI:IPI00152542.2 DmX-like protein 2;Rabconnectin-3 DMXL2;KIAA0856 Q8TDJ6 ENST00000251076 1 NaN NaN 0.54766 NaN NaN 0.79011 OTU 2 2 2 4.5 4.5 4.5 33.3 0.0064992 9214700 5107700 4107000 2841 IPI:IPI00152599.3 OTU domain-containing protein 6A;DUBA-2 OTUD6A;DUBA2 Q7L8S5 ENST00000338352 1 0.77991 1.4825 0.80758 1.0669 0.99768 1.049 Pkinase cell part;cytoplasm;intracellular part ATP binding;binding;catalytic activity;kinase activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;protein tyrosine kinase activity;purine nucleoside binding cellular biopolymer metabolic process;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process 18 18 18 59.3 59.3 59.3 34.551 1.62E-234 715480000 355120000 360350000 2842 IPI:IPI00152658.1;IPI:IPI00550738.4 Serine/threonine-protein kinase Nek7;NimA-related protein kinase 7 NEK7 Q8TDX7 ENST00000367385;ENST00000391974 K08857 2 0.85712 1.8017 0.91631 1.1153 1.1387 1.1052 9 9 9 12.4 12.4 12.4 93.908 8.9413E-79 69175000 36251000 32924000 2843 IPI:IPI00152671.7 Protein FAM91A1 FAM91A1 Q658Y4 ENST00000334705 1 0.46702 1.0484 0.50084 0.62064 0.67484 0.67512 TPR_1 binding 2 2 2 3.5 3.5 3.5 79.374 3.0394E-76 7331200 4521000 2810300 2844 IPI:IPI00152685.10 Tetratricopeptide repeat protein 15 TTC15;CGI-87 Q8WVT3 ENST00000324266;ENST00000382110 1 0.49758 NaN NaN 0.61493 NaN NaN Nol1_Nop2_Fmu;PUA binding;catalytic activity;methyltransferase activity;nucleic acid binding;RNA binding;transferase activity;transferase activity, transferring one-carbon groups 4 4 4 9.2 9.2 9.2 51.77 2.0359E-35 2384000 1306000 1078000 2845 IPI:IPI00152688.1 Putative methyltransferase NSUN6;NOL1/NOP2/Sun domain family member 6;NOL1/NOP2/Sun and PUA domain-containing protein 1 NSUN6;NOPD1 Q8TEA1 ENST00000377304 1 NaN 1.5231 0.77101 NaN 1.0799 1.1186 Tyr_Deacylase cell part;cytoplasm;intracellular part catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds amine metabolic process;catabolic process;cellular amino acid and derivative metabolic process;cellular amino acid catabolic process;cellular amino acid metabolic process;metabolic process;nitrogen compound metabolic process;organic acid metabolic process 3 3 3 20.1 20.1 20.1 23.423 4.4209E-61 17798000 9568200 8229400 2846 IPI:IPI00152692.2 D-tyrosyl-tRNA(Tyr) deacylase 1;Histidyl-tRNA synthetase-related DTD1;C20orf88;HARS2 Q8TEA8 ENST00000377452 K07560 1 0.93223 1.5352 0.90185 1.218 1.0334 1.2798 WD40 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 13 13 13 39.6 39.6 39.6 35.079 4.961E-197 394150000 200550000 193600000 2847 IPI:IPI00152695.2 WD repeat-containing protein 82;Swd2 WDR82;WDR82A;UNQ9342/PRO34047 Q6UXN9 ENST00000296490 1 0.44317 1.0956 0.38019 0.59885 0.66019 0.59839 U3_snoRNA_C;WD40 cell part;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 9 9 9 21.8 21.8 21.8 58.354 1.0747E-126 126640000 69708000 56931000 2849 IPI:IPI00152708.3 U3 small nucleolar RNA-associated protein 15 homolog UTP15 Q8TED0 ENST00000296792 1 NaN 0.87035 NaN NaN 0.55414 NaN cell part;cytoplasmic part;cytosol;endoplasmic reticulum lumen;endoplasmic reticulum part;intracellular organelle lumen;intracellular organelle part;intracellular part;membrane-enclosed lumen;organelle lumen;organelle part antigen binding;ATP binding;binding;catalytic activity;nucleoside binding;nucleotide binding;peptide transporter activity;primary active transmembrane transporter activity;protein binding;purine nucleoside binding;receptor binding;transporter activity antigen processing and presentation of endogenous peptide antigen;antigen processing and presentation of peptide antigen via MHC class I;immune system process;intracellular protein transport;protein complex assembly;transport 3 3 3 4.3 4.3 4.3 90.851 8.6471E-18 9494800 4631800 4863000 2850 IPI:IPI00152769.4;IPI:IPI00219534.1 Trpc4-associated protein;Short transient receptor potential channel 4-associated protein;TAP1 protein;TNF-receptor ubiquitous scaffolding/signaling protein TRPC4AP;C20orf188;TRRP4AP Q8TEL6-1;Q8TEL6;Q8TEL6-2 ENST00000252015 K11796 2 1.0271 0.90147 NaN 1.2849 0.59681 NaN cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle actin binding;binding;cytoskeletal protein binding;protein binding 6 6 6 14.4 14.4 14.4 67.942 5.8446E-130 67473000 33874000 33599000 2852 IPI:IPI00152853.3;IPI:IPI00445658.2 Phostensin;Protein phosphatase 1 F-actin cytoskeleton-targeting subunit KIAA1949;HKMT1098 Q6NYC8-1;Q6NYC8;Q6NYC8-2 ENST00000274853;ENST00000376424;ENST00000399199 2 NaN 1.7202 NaN NaN 1.0935 NaN 2 2 2 3.3 3.3 3.3 105.02 3.4765E-07 899730 504070 395650 2853 IPI:IPI00152863.4;IPI:IPI00845255.3 Smith-Magenis syndrome chromosomal region candidate gene 8 protein SMCR8 Q8TEV9-1;Q8TEV9;Q8TEV9-2 ENST00000316811;ENST00000395695;ENST00000406438 2 0.43828 0.90105 0.45426 0.56199 0.57687 0.57974 Nrap chromosome;condensed chromosome;condensed nuclear chromosome;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nuclear chromosome;nucleolus;organelle;ribonucleoprotein complex;small nucleolar ribonucleoprotein complex binding;nucleic acid binding;RNA binding 22 22 22 23.6 23.6 23.6 127.59 1.4556E-189 398020000 232500000 165520000 2854 IPI:IPI00152890.1;IPI:IPI00556218.1;IPI:IPI00157845.3;IPI:IPI00291903.4 Nucleolar protein 6;Nucleolar RNA-associated protein NOL6 Q9H6R4-1;Q9H6R4;Q9H6R4-4;Q9H6R4-2;Q9H6R4-3 ENST00000297990;ENST00000325914;ENST00000353159 4 0.89119 1.6466 0.9179 1.1173 1.179 1.1151 Clat_adaptor_s AP-1 adaptor complex;AP-type membrane coat adaptor complex;clathrin adaptor complex;coated pit;cytoplasmic part;cytoplasmic vesicle part;cytosol;Golgi apparatus part;intracellular part;macromolecular complex;membrane part;organelle part;protein complex binding;protein binding;protein transporter activity;substrate-specific transporter activity;transporter activity cellular component organization;cellular process;endocytosis;intracellular protein transport;membrane invagination;membrane organization;protein transport;receptor-mediated endocytosis;transport;vesicle-mediated transport 6 6 4 36.1 36.1 26.6 18.733 8.2771E-73 97272000 46613000 50658000 2855 IPI:IPI00152898.1;IPI:IPI00100559.1;IPI:IPI00654799.1;IPI:IPI00060866.2;IPI:IPI00915398.2 AP-1 complex subunit sigma-1A;Adapter-related protein complex 1 sigma-1A subunit;Adaptor protein complex AP-1 sigma-1A subunit;Sigma-adaptin 1A;Sigma1A-adaptin;Golgi adaptor HA1/AP1 adaptin sigma-1A subunit;HA1 19 kDa subunit;Clathrin assembly protein complex 1 sigma-1A small chain;Clathrin coat assembly protein AP19;Sigma 1a subunit of AP-1 clathrin AP1S1;AP19;CLAPS1 P61966-1;P61966;P61966-2 ENST00000337619 K12394 5 0.69522 1.5378 0.82772 0.94589 1.0059 1.0481 ICAT beta-catenin binding;binding;protein binding 3 3 3 16.1 16.1 16.1 23.925 3.4254E-45 71747000 38674000 33073000 2856 IPI:IPI00152900.2 Protein LZIC;Leucine zipper and ICAT homologous domain-containing protein;Leucine zipper and CTNNBIP1 domain-containing protein LZIC Q8WZA0 ENST00000377213;ENST00000377223;ENST00000400903 1 1.2051 2.2416 1.0886 1.5208 1.4372 1.4769 C1_1;RhoGAP acrosomal vesicle;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;intracellular organelle;membrane-bounded organelle;membrane-bounded vesicle;microtubule;non-membrane-bounded organelle;nucleus;organelle;secretory granule;spindle;vesicle binding;cytoskeletal protein binding;diacylglycerol binding;enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;lipid binding;protein binding;protein C-terminus binding;tubulin binding;zinc ion binding anion transport;cell communication;cytokinesis, contractile ring formation;cytokinesis, initiation of separation;cytoskeleton organization;formation of actomyosin apparatus involved in cytokinesis;ion transport;organelle organization;transport 13 13 13 24.7 24.7 24.7 71.026 3.1155E-97 227410000 118220000 109190000 2857 IPI:IPI00152946.1 Rac GTPase-activating protein 1;Male germ cell RacGap RACGAP1;KIAA1478;MGCRACGAP Q9H0H5 ENST00000312377 1 0.68354 1.2747 0.69971 0.84857 0.90452 0.9435 RRN3 cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 3 3 3 4.6 4.6 4.6 74.106 7.2238E-14 18886000 10124000 8761900 2858 IPI:IPI00152960.2;IPI:IPI00177929.4 RNA polymerase I-specific transcription initiation factor RRN3;Transcription initiation factor IA;RRN3-like protein 1 RRN3;TIFIA Q9NYV6;A6NIE6 ENST00000198767 2 0.73334 1.8419 0.72354 0.91321 1.1003 0.87398 DUF1640 cell part;cytoplasmic part;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane part;membrane-bounded organelle;mitochondrion;organelle 4 4 4 9.2 9.2 9.2 39.694 7.5347E-26 59047000 31890000 27157000 2859 IPI:IPI00152975.3 Coiled-coil domain-containing protein 90A, mitochondrial CCDC90A;C6orf79 Q96AQ8-1;Q96AQ8 ENST00000359495;ENST00000379170 1 0.73221 1.7848 0.79996 1.0175 1.1802 1.0653 Acyl-CoA_dh_1;Acyl-CoA_dh_M;Acyl-CoA_dh_N cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle acyl-CoA dehydrogenase activity;binding;catalytic activity;electron carrier activity;nucleoside binding;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on the CH-CH group of donors;purine nucleoside binding metabolic process;oxidation reduction 1- and 2-Methylnaphthalene degradation;Geraniol degradation 17 17 17 29.5 29.5 29.5 68.76 2.3795E-87 785470000 637250000 148220000 2860 IPI:IPI00152981.1 Acyl-CoA dehydrogenase family member 9, mitochondrial ACAD9 Q9H845 ENST00000308982 K00257 1 0.31839 0.58097 0.34238 0.40726 0.41005 0.46152 LRR_1 binding;protein binding 10 10 10 19.1 19.1 19.1 68.249 4.9479E-134 32378000 18058000 14320000 2861 IPI:IPI00152998.3 Leucine-rich repeat-containing protein 40 LRRC40 Q9H9A6 ENST00000370952 1 0.87518 1.9509 0.63045 1.1609 1.3376 0.7646 cell part;integral to membrane;intrinsic to membrane;membrane part cation channel activity;cation transmembrane transporter activity;channel activity;ion channel activity;ion transmembrane transporter activity;passive transmembrane transporter activity;transporter activity;voltage-gated ion channel activity cation transport;hydrogen transport;ion transport;monovalent inorganic cation transport;proton transport;response to abiotic stimulus;response to inorganic substance;response to metal ion;response to pH;response to zinc ion;transport 3 3 3 11.7 11.7 11.7 31.683 1.1937E-25 24440000 14092000 10348000 2862 IPI:IPI00153005.1;IPI:IPI00872288.2;IPI:IPI00478137.3 Voltage-gated hydrogen channel 1;Hydrogen voltage-gated channel 1;Voltage sensor domain-only protein HVCN1;VSOP;UNQ578/PRO1140 Q96D96-1;Q96D96;Q96D96-3;Q96D96-2 ENST00000356742 3 0.70477 1.4918 0.61973 0.89983 1.0189 0.7698 cell part;integral to membrane;intrinsic to membrane;membrane part 4 4 4 14.1 14.1 14.1 45.811 5.4867E-49 44005000 24860000 19145000 2863 IPI:IPI00153023.7;IPI:IPI00795428.3 Coiled-coil domain-containing protein 51 CCDC51 Q96ER9-1;Q96ER9;Q96ER9-2 ENST00000296441;ENST00000395694;ENST00000395696 2 0.58267 1.0832 0.5581 0.82475 0.699 0.75227 LTV 10 10 10 25.7 25.7 25.7 54.854 3.0176E-205 233500000 122550000 110950000 2864 IPI:IPI00153032.1 Protein LTV1 homolog LTV1 Q96GA3 ENST00000367576 1 0.78552 1.4812 0.72843 1.1508 0.96128 0.93795 cell part;cytoplasm;integral to membrane;intracellular part;intrinsic to membrane;membrane part binding;protein binding 12 12 12 18 18 18 102.18 2.7587E-142 170140000 86429000 83715000 2865 IPI:IPI00154283.4;IPI:IPI00789801.2 Protein CIP2A;Cancerous inhibitor of PP2A;p90 autoantigen KIAA1524;CIP2A Q8TCG1-1;Q8TCG1;Q8TCG1-2 ENST00000295746 2 0.8104 1.6064 0.79724 1.097 1.0383 1.0388 EFG_C;EFG_IV;GTP_EFTU;GTP_EFTU_D2 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;nucleic acid binding;nucleotide binding;pyrophosphatase activity;translation elongation factor activity;translation factor activity, nucleic acid binding biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation 26 26 26 37 37 37 83.471 1.2261E-231 1308100000 691230000 616900000 2866 IPI:IPI00154473.5;IPI:IPI00945964.1 Elongation factor G 1, mitochondrial;mEF-G 1;Elongation factor G1 GFM1;EFG;EFG1;GFM Q96RP9-1;Q96RP9;Q96RP9-2 ENST00000264263 K02355 2 0.9377 2.1982 1.0339 1.2581 1.3805 1.421 FHA cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding 5 5 5 14.9 14.9 14.9 45.777 1.0016E-27 80005000 40551000 39454000 2867 IPI:IPI00154515.3 Smad nuclear-interacting protein 1 SNIP1 Q8TAD8 ENST00000296215 1 0.51156 1.1558 0.55023 0.66474 0.7236 0.71129 SMC_N cell part;chromosome;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cellular process;DNA metabolic process;DNA recombination;DNA repair;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to DNA damage stimulus;response to stress 6 6 6 6.7 6.7 6.7 129.15 4.5329E-33 14159000 8139300 6020100 2868 IPI:IPI00816217.1;IPI:IPI00154528.3 Structural maintenance of chromosomes protein 6 SMC6;SMC6L1 Q96SB8-2;Q96SB8;Q96SB8-1 ENST00000351948;ENST00000381272;ENST00000402989 2 0.60026 1.2869 0.63799 0.83296 0.81648 0.82667 RRM_1 chromosome;condensed chromosome;condensed nuclear chromosome;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;nuclear chromosome;nucleolus;nucleoplasm;organelle;organelle part binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein complex assembly;transcription;transcription, DNA-dependent 7 7 7 24.6 24.6 24.6 34.222 4.099E-148 291150000 156250000 134900000 2869 IPI:IPI00154590.6 MKI67 FHA domain-interacting nucleolar phosphoprotein;Nucleolar protein interacting with the FHA domain of pKI-67;Nucleolar phosphoprotein Nopp34 MKI67IP;NIFK;NOPP34 Q9BYG3 ENST00000285814 1 0.75371 1.3483 NaN 1.0412 0.8506 NaN RRM_1;zf-CCHC cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;ribonucleoprotein complex;spliceosomal complex;U12-type spliceosomal complex binding;cation binding;ion binding;metal ion binding;nucleic acid binding;nucleotide binding;RNA binding;transition metal ion binding;zinc ion binding cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 2 2 2 14.3 14.3 14.3 24.591 1.5003E-49 6061800 3152800 2909000 2870 IPI:IPI00154614.4 Zinc finger CCHC-type and RNA-binding motif-containing protein 1;U11/U12 small nuclear ribonucleoprotein 31 kDa protein ZCRB1 Q8TBF4 ENST00000266529 1 0.92567 1.3884 0.85652 1.2031 0.94703 1.1663 TBC cell part;intracellular enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity;Rab GTPase activator activity;Ras GTPase activator activity;small GTPase regulator activity biological regulation;regulation of catalytic activity;regulation of GTPase activity;regulation of hydrolase activity;regulation of molecular function;regulation of Rab GTPase activity;regulation of Ras GTPase activity 17 17 17 27.2 27.2 27.2 82.161 5.6426E-97 222540000 114790000 107750000 2871 IPI:IPI00154645.8;IPI:IPI00794613.4 TBC1 domain family member 15 TBC1D15 Q8TC07-1;Q8TC07;Q8TC07-2 ENST00000319106;ENST00000407399 2 0.87909 1.5773 NaN 1.1086 1.1194 NaN KOG2701 6 6 6 8.9 8.9 8.9 73.197 2.453E-10 48989000 23131000 25857000 2872 IPI:IPI00154668.5 Coiled-coil domain-containing protein 93 CCDC93 Q567U6 ENST00000376300 1 0.62481 1.4157 0.76977 0.96073 0.91613 1.0176 binding;protein binding 3 3 3 19.3 19.3 19.3 21.609 5.6272E-12 45374000 23131000 22243000 2874 IPI:IPI00154778.1;IPI:IPI00946015.1 Protein Muted homolog MUTED Q8TDH9-1;Q8TDH9;Q8TDH9-2 ENST00000244777;ENST00000379757;ENST00000397456 2 0.67462 1.6535 0.67863 0.98904 1.0148 0.98195 DnaJ binding;heat shock protein binding;protein binding 11 11 11 40.8 40.8 40.8 29.909 2.7634E-244 577320000 316460000 260860000 2875 IPI:IPI00154975.3 DnaJ homolog subfamily C member 9;DnaJ protein SB73 DNAJC9 Q8WXX5 ENST00000372950 K09529 1 0.73701 1.5319 0.80529 0.95719 1.095 0.96619 zf-C3HC4 binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding 3 3 3 16.2 16.2 16.2 35.685 1.6558E-31 109440000 55229000 54211000 2877 IPI:IPI00745921.2;IPI:IPI00155562.1 RING finger protein 126 RNF126 Q9BV68-1;Q9BV68;Q9BV68-2 ENST00000292363;ENST00000340092 K11982 2 0.95676 1.5193 0.96916 1.1823 1.0474 1.2047 Macro 4 4 4 17.8 17.8 17.8 35.505 7.0691E-68 89297000 44378000 44918000 2878 IPI:IPI00155601.1 MACRO domain-containing protein 1;Protein LRP16 MACROD1;LRP16 Q9BQ69 ENST00000255681 1 0.73354 1.5504 0.82036 0.95874 1.0363 1.0647 KH_1 intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nucleolus;organelle;organelle part;ribonucleoprotein complex;small nucleolar ribonucleoprotein complex binding;nucleic acid binding;RNA binding cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 10 10 10 24.1 24.1 24.1 43.664 2.0263E-115 507970000 270040000 237940000 2879 IPI:IPI00156032.6 KRR1 small subunit processome component homolog;HIV-1 Rev-binding protein 2;Rev-interacting protein 1 KRR1;HRB2 Q13601 ENST00000229214 K06961 1 0.79661 1.5138 0.79089 0.98813 1.0574 0.99183 PCI;RPN7 cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex;signalosome binding;enzyme inhibitor activity;enzyme regulator activity;GTPase inhibitor activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity;protein binding cell communication;cell cycle;cellular process;inactivation of MAPK activity;intracellular signaling cascade;JNK cascade;MAPKKK cascade;negative regulation of protein kinase activity;protein kinase cascade;response to stress;signal transduction 16 16 16 31.1 31.1 31.1 59.05 8.1941E-95 431370000 225300000 206070000 2880 IPI:IPI00414289.1;IPI:IPI00156282.2;IPI:IPI00921488.1;IPI:IPI00300386.7 COP9 signalosome complex subunit 1;JAB1-containing signalosome subunit 1;G protein pathway suppressor 1;Protein MFH GPS1;COPS1;CSN1 Q13098-7;Q13098;Q13098-4;Q13098-5;Q13098-6 ENST00000306823;ENST00000320548 K12175 4 0.54665 1.0833 0.5295 0.70871 0.71952 0.66648 HEAT;IBN_N cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;organelle part;pore complex;protein complex binding;protein binding;protein transporter activity;substrate-specific transporter activity;transporter activity anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;protein complex assembly;protein import into nucleus, docking 27 27 27 31.9 31.9 31.9 118.9 0 864270000 465100000 399170000 2881 IPI:IPI00398009.2;IPI:IPI00156374.6 Importin-4;Importin-4b;Ran-binding protein 4 IPO4;IMP4B;RANBP4 Q8TEX9-2;Q8TEX9;Q8TEX9-1 ENST00000354464 2 0.72554 1.4532 0.70832 0.92697 0.95769 0.92369 ADH_N;ADH_zinc_N cell part;integral to membrane;intrinsic to membrane;membrane part binding;catalytic activity;cation binding;ion binding;metal ion binding;oxidoreductase activity;transition metal ion binding;zinc ion binding metabolic process;oxidation reduction 22 22 22 68.2 68.2 68.2 41.92 0 2435700000 1319700000 1116000000 2882 IPI:IPI00156689.3 Synaptic vesicle membrane protein VAT-1 homolog VAT1 Q99536 ENST00000355653 K00540 1 0.49108 1.1066 0.36517 0.6875 0.62135 0.51921 BHD_1;BHD_2;BHD_3;Rad4 cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;damaged DNA binding;DNA binding;nucleic acid binding;protein binding;single-stranded DNA binding;structure-specific DNA binding catabolic process;DNA catabolic process;DNA metabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleotide-excision repair, DNA damage removal Nucleotide excision repair 6 6 6 8.3 8.3 8.3 105.98 4.0252E-17 53474000 32838000 20637000 2883 IPI:IPI00156793.5 DNA repair protein complementing XP-C cells;Xeroderma pigmentosum group C-complementing protein;p125 XPC;XPCC Q01831 ENST00000285021 K10838 1 0.65966 1.13 NaN 0.85615 0.691 NaN Peptidase_C54 cytosol;extracellular region;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;microtubule associated complex;nucleus;organelle;organelle part;protein complex binding;catalytic activity;cysteine-type endopeptidase activity;cysteine-type peptidase activity;cytoskeletal protein binding;endopeptidase activity;hydrolase activity;microtubule binding;peptidase activity;protein binding;tubulin binding autophagic vacuole formation;catabolic process;intracellular protein transport;metabolic process;organelle organization;protein targeting;protein targeting to membrane;protein targeting to vacuole;proteolysis;transport;vacuolar transport Regulation of autophagy 3 3 3 6.1 6.1 6.1 52.497 0.00041736 2165200 1240100 925100 2884 IPI:IPI00156979.1 Cysteine protease ATG4C;Autophagy-related protein 4 homolog C;Autophagin-3;Autophagy-related cysteine endopeptidase 3;AUT-like 3 cysteine endopeptidase ATG4C;APG4C;AUTL1;AUTL3 Q96DT6 ENST00000317868;ENST00000371120 K08342 1 0.76429 1.2126 0.70665 0.90066 0.88178 0.84423 DUF2366 3 3 3 15 15 15 29.233 2.7717E-26 52113000 26790000 25323000 2886 IPI:IPI00157215.5 Uncharacterized protein C19orf52 C19orf52 Q9BSF4 ENST00000270502 1 0.87854 1.4691 0.8487 1.1899 0.9918 1.024 UBA cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 4 4 4 8.6 8.6 8.6 71.921 7.6863E-44 29847000 15002000 14844000 2887 IPI:IPI00157365.2;IPI:IPI00377271.1 NEDD8 ultimate buster 1;Negative regulator of ubiquitin-like proteins 1;Renal carcinoma antigen NY-REN-18 NUB1;NYREN18 Q9Y5A7-2;Q9Y5A7;Q9Y5A7-1 ENST00000355851 2 0.71878 1.5245 0.67257 0.97758 1.0194 0.98974 Sec6 cellular process;establishment of localization;establishment of localization in cell;establishment of protein localization;exocytosis;protein transport;secretion;secretion by cell;transport;vesicle-mediated transport 7 7 7 11.8 11.8 11.8 86.844 2.2057E-40 86932000 47518000 39413000 2888 IPI:IPI00157734.2;IPI:IPI00219954.1 Exocyst complex component 3;Exocyst complex component Sec6 EXOC3;SEC6;SEC6L1 O60645-1;O60645;O60645-2 ENST00000315013;ENST00000340158 2 0.69052 1.6739 0.80305 0.85294 1.1751 1.0353 CH;FAD_binding_3;LIM cell part;cytoplasm;cytoskeletal part;intermediate filament;intracellular organelle part;intracellular part;organelle part binding;catalytic activity;cation binding;ion binding;metal ion binding;monooxygenase activity;oxidoreductase activity;protein binding;protein domain specific binding;SH3 domain binding;transition metal ion binding;zinc ion binding biological regulation;cell communication;cellular component organization;cellular process;cytoskeleton organization;organelle organization;regulation of biological process;regulation of cellular process;signal transduction 9 9 9 13.1 13.1 13.1 119.82 8.6154E-54 48719000 25267000 23452000 2889 IPI:IPI00157757.7;IPI:IPI00647681.2;IPI:IPI00386301.1 NEDD9-interacting protein with calponin homology and LIM domains;Molecule interacting with CasL protein 1 MICAL1;MICAL;NICAL Q8TDZ2-1;Q8TDZ2;Q8TDZ2-2 ENST00000335266;ENST00000358577;ENST00000358807 3 0.91129 1.8915 0.92322 1.23 1.2752 1.1912 HEAT centrosome;cytoplasmic membrane-bounded vesicle;cytosol;early endosome;endoplasmic reticulum;endosome;ER-Golgi intermediate compartment;Golgi-associated vesicle;late endosome;microtubule organizing center;nucleus;transport vesicle binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;misfolded or incompletely synthesized protein catabolic process;proteasomal protein catabolic process;proteolysis;ubiquitin-dependent protein catabolic process 23 23 23 14.4 14.4 14.4 223.69 0 110980000 57735000 53241000 2890 IPI:IPI00157790.7 Proteasome-associated protein ECM29 homolog ECM29;KIAA0368 Q5VYK3 ENST00000259335 1 0.77736 1.6436 0.86558 1.0296 1.0312 1.1166 G-patch;Surp cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;RNA binding cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 10 10 10 11.4 11.4 11.4 121.31 3.802E-112 204650000 110250000 94393000 2891 IPI:IPI00554436.2;IPI:IPI00158020.8;IPI:IPI00554438.1 Putative splicing factor, arginine/serine-rich 14;Arginine/serine-rich-splicing factor 14 SFRS14;KIAA0365 Q8IX01-3;Q8IX01;Q8IX01-1;Q8IX01-4 ENST00000330854;ENST00000337018;ENST00000392342 3 0.66829 1.3382 0.67735 1.043 0.87901 1.0001 R3H;zf-C3HC4;zf-NF-X1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;cation binding;DNA binding;ion binding;ligase activity;metal ion binding;nucleic acid binding;transcription factor activity;transcription regulator activity;transition metal ion binding;zinc ion binding negative regulation of transcription from RNA polymerase II promoter;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription;transcription, DNA-dependent 9 9 9 13.7 13.7 13.7 124.39 1.1176E-148 20472000 11668000 8804700 2892 IPI:IPI00843917.1;IPI:IPI00158157.1;IPI:IPI00158159.3;IPI:REV_IPI00169284.10;IPI:REV_IPI00446611.1 Transcriptional repressor NF-X1;Nuclear transcription factor, X box-binding protein 1 NFX1;NFX2 Q12986-1;Q12986;Q12986-2;Q12986-3 ENST00000318524;ENST00000379521;ENST00000379540 K12236 5 NaN NaN 0.7223 NaN NaN 1.0445 transcription regulator activity;transcription repressor activity cell activation;cell activation during immune response;immune system process;leukocyte activation during immune response;macrophage activation during immune response;myeloid cell activation during immune response;myeloid leukocyte activation 6 2 2 5.3 1.6 1.6 151.82 1.2133E-55 41235000 22953000 18283000 2893 IPI:IPI00878948.1;IPI:IPI00158514.5;IPI:REV_IPI00878948.1;IPI:REV_IPI00158514.5 Protein strawberry notch homolog 2 SBNO2;KIAA0963 Q9Y2G9-2;Q9Y2G9;Q9Y2G9-1 ENST00000250872;ENST00000361757 4 0.81935 0.96997 0.36462 1.2411 0.60826 0.52467 KH_1;RII_binding_1;TUDOR cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial membrane;mitochondrial outer membrane;mitochondrial part;organelle membrane;organelle outer membrane;organelle part;outer membrane binding;nucleic acid binding;protein binding;RNA binding 6 6 6 11.7 11.7 11.7 97.34 5.227E-14 59668000 29908000 29760000 2894 IPI:IPI00942186.1;IPI:IPI00158627.1 A kinase anchor protein 1, mitochondrial;Protein kinase A-anchoring protein 1;A-kinase anchor protein 149 kDa;Dual specificity A-kinase-anchoring protein 1;Spermatid A-kinase anchor protein 84 AKAP1;AKAP149;PRKA1 Q92667-1;Q92667;Q92667-2 ENST00000314126;ENST00000337714 2 0.71733 1.4996 NaN 0.94831 1.0041 NaN cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;ion binding;nucleic acid binding;protein binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding;transcription regulator activity;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 4 4 4 4.2 4.2 4.2 211.77 3.2333E-43 8406000 3861900 4544000 2895 IPI:IPI00159322.4;IPI:IPI00220381.2 Transcription factor 20;Stromelysin 1 PDGF-responsive element-binding protein;Nuclear factor SPBP;AR1 TCF20;KIAA0292;SPBP Q9UGU0-1;Q9UGU0;Q9UGU0-2 ENST00000335626;ENST00000359486 2 0.73893 NaN 0.77174 0.89342 NaN 0.94675 intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;mitochondrial ribosome;non-membrane-bounded organelle;organellar ribosome;organelle;organelle part;ribonucleoprotein complex;ribosome structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 5 5 5 28.9 28.9 28.9 20.576 8.5905E-07 80293000 44627000 35667000 2899 IPI:IPI00160421.3 39S ribosomal protein L18, mitochondrial MRPL18;HSPC071 Q9H0U6 ENST00000367034 1 0.69575 0.98063 0.74412 0.92345 0.63728 0.98462 cell projection;centriole;cilium;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;microtubule basal body;microtubule organizing center;non-membrane-bounded organelle;organelle;organelle part;protein complex binding;enzyme binding;kinase binding;protein binding;protein C-terminus binding;protein kinase binding cell cycle;cellular component organization;cellular process;centriole-centriole cohesion;microtubule organizing center organization;mitotic cell cycle;organelle organization;protein localization;regulation of centriole-centriole cohesion 3 3 3 1.6 1.6 1.6 281.13 2.8632E-35 49784000 27497000 22287000 2900 IPI:IPI00160622.1;IPI:IPI00292871.1 Centrosome-associated protein CEP250;Centrosomal protein 2;Centrosomal Nek2-associated protein 1 CEP250;CEP2;CNAP1 Q9BV73-1;Q9BV73;Q9BV73-2 ENST00000342580;ENST00000356095;ENST00000397527 2 0.69127 1.2515 0.71752 0.89813 0.81389 0.91989 RRM_1 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding biosynthetic process;DNA metabolic process;DNA replication;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of cell growth 8 8 8 8.7 8.7 8.7 131.85 9.9839E-12 106690000 55381000 51308000 2901 IPI:IPI00161085.5;IPI:IPI00940050.1;IPI:IPI00952881.1;IPI:IPI00480054.3;IPI:REV_IPI00829741.2;IPI:IPI00300536.8;IPI:IPI00892538.1;IPI:IPI00892678.1 Nucleolar protein 8;Nucleolar protein Nop132 NOL8;C9orf34;NOP132 Q76FK4-2;Q76FK4;Q76FK4-1;Q76FK4-4;Q76FK4-3 ENST00000358855;ENST00000375594 8 NaN NaN 0.78436 NaN NaN 1.0822 Ank cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;molecular transducer activity;protein binding;signal transducer activity;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding;transcription regulator activity biosynthetic process;cell communication;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;signal transduction;transcription Adipocytokine signaling pathway;B cell receptor signaling pathway;Chemokine signaling pathway;T cell receptor signaling pathway 3 3 3 8.7 8.7 8.7 37.771 1.7432E-54 26953000 14247000 12705000 2902 IPI:IPI00161119.3;IPI:IPI00514744.1 NF-kappa-B inhibitor beta;I-kappa-B-beta;Thyroid receptor-interacting protein 9 NFKBIB;IKBB;TRIP9 Q15653-1;Q15653;Q15653-2 ENST00000313582;ENST00000392079 K02581 2 0.68785 1.4999 0.68667 0.91558 1.0048 0.95736 intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;mitochondrial ribosome;non-membrane-bounded organelle;organellar ribosome;organelle;organelle part;ribonucleoprotein complex;ribosome structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 13 13 13 35.7 35.7 35.7 48.117 7.4436E-209 311880000 166670000 145220000 2904 IPI:IPI00162330.3 39S ribosomal protein L37, mitochondrial;MRP-L37 MRPL37;MRPL2;RPML2;HSPC235 Q9BZE1 ENST00000360840 1 1.0148 1.7042 NaN 1.272 1.2012 NaN PHD;SAND;Sp100 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity;ion binding;nucleic acid binding;protein binding;receptor signaling protein activity;signal transducer activity;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 2 2 2 2.9 2.9 2.9 81.267 4.5509E-06 1982700 1154300 828480 2905 IPI:IPI00913939.1;IPI:IPI00162549.4;IPI:IPI00472430.3;IPI:IPI00220747.5 Sp110 nuclear body protein;Transcriptional coactivator Sp110;Speckled 110 kDa;Interferon-induced protein 41/75 SP110 Q9HB58-6;Q9HB58;Q9HB58-1;Q9HB58-3;Q9HB58-5 ENST00000258381;ENST00000258382;ENST00000358662;ENST00000392048 4 0.86022 1.6311 0.92151 1.1631 1.0741 1.2038 zf-C3HC4 cell part;chromosome;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle binding;catalytic activity;cation binding;ion binding;ligase activity;metal ion binding;protein binding;transition metal ion binding;zinc ion binding catabolic process;cellular component organization;cellular process;chromatin modification;chromatin organization;macromolecule catabolic process;metabolic process;organelle organization;protein metabolic process;proteolysis 16 15 15 16.5 15.1 15.1 113.68 2.2765E-124 240030000 112390000 127640000 2906 IPI:IPI00162563.5;IPI:IPI00290648.2;IPI:IPI00377273.3 E3 ubiquitin-protein ligase BRE1B;RING finger protein 40;95 kDa retinoblastoma-associated protein;RBP95 RNF40;BRE1B;KIAA0661 O75150-1;O75150;O75150-4;O75150-3 ENST00000324685;ENST00000357890;ENST00000402121 K10696 3 0.63931 1.084 0.61207 0.80738 0.72158 0.76455 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;ribonucleoprotein complex;spliceosomal complex binding;protein binding DNA metabolic process;DNA repair;mRNA processing;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleotide-excision repair;RNA processing;transcription;transcription-coupled nucleotide-excision repair 17 17 17 20.7 20.7 20.7 100.01 7.487E-153 279320000 147060000 132260000 2907 IPI:IPI00163084.3 Pre-mRNA-splicing factor SYF1;XPA-binding protein 2;Protein HCNP XAB2;HCNP;KIAA1177;SYF1;PP3898 Q9HCS7 ENST00000358368 1 0.80545 1.6943 0.78099 1.0722 1.089 1.0359 Mov34 cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex;signalosome binding;protein binding interspecies interaction between organisms;multi-organism process 14 14 14 52.6 52.6 52.6 36.163 1.1916E-139 825490000 441330000 384160000 2908 IPI:IPI00163230.5 COP9 signalosome complex subunit 6;JAB1-containing signalosome subunit 6;Vpr-interacting protein;MOV34 homolog COPS6;CSN6;HVIP Q7L5N1 ENST00000303904 K12179 1 1.0326 2.1142 1.0251 1.3235 1.2932 1.4788 Methyltransf_10 catalytic activity;methyltransferase activity;transferase activity;transferase activity, transferring one-carbon groups 12 12 12 28.1 28.1 28.1 63.62 6.7659E-37 446780000 71273000 375510000 2909 IPI:IPI00163391.7;IPI:IPI00792378.1 Putative methyltransferase METT10D;Methyltransferase 10 domain-containing protein METT10D Q86W50-1;Q86W50 ENST00000263092;ENST00000399834 K11393 2 0.6151 0.95824 0.5737 0.83134 0.64856 0.72346 K_tetra cation channel complex;cell part;ion channel complex;macromolecular complex;membrane part;plasma membrane part;potassium channel complex;protein complex;voltage-gated potassium channel complex cation channel activity;cation transmembrane transporter activity;ion channel activity;ion transmembrane transporter activity;potassium channel activity;transporter activity;voltage-gated ion channel activity;voltage-gated potassium channel activity cation transport;establishment of localization;ion transport;metal ion transport;monovalent inorganic cation transport;potassium ion transport;transport 6 6 6 10.3 10.3 10.3 76.343 5.5282E-68 10384000 6394700 3989200 2910 IPI:IPI00163403.7;IPI:IPI00384008.3;IPI:IPI00410103.2;IPI:IPI00783521.1 SH3KBP1-binding protein 1 SHKBP1;PP203 Q8TBC3-1;Q8TBC3;Q8TBC3-2 ENST00000291842 4 0.78807 1.7075 0.86204 0.9997 1.0622 1.1421 SAM_1;SAM_2 cell part;cytoplasm;intracellular part binding;molecular transducer activity;protein binding;signal transducer activity biological adhesion;biological regulation;cell adhesion;cell communication;cell-matrix adhesion;cell-substrate adhesion;cellular process;regulation of biological process;regulation of cellular process;signal transduction 12 12 10 12.8 12.8 11 135.78 3.1716E-66 67143000 37461000 29682000 2911 IPI:IPI00163496.12;IPI:IPI00219754.1;IPI:IPI00289271.6;IPI:IPI00916144.1;IPI:IPI00397579.1 Liprin-alpha-1;Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1;LAR-interacting protein 1 PPFIA1;LIP1 Q13136-1;Q13136;Q13136-2 ENST00000253925;ENST00000389547 5 0.95904 1.7061 0.94369 1.2351 1.1283 1.1885 RRM_1 cell part;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle;organelle part binding;nucleic acid binding;nucleotide binding;RNA binding biosynthetic process;metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;RNA processing;RNA splicing;transcription 16 16 14 36.4 36.4 31.5 59.379 4.065E-293 2433600000 1227000000 1206600000 2912 IPI:IPI00163505.2;IPI:IPI00215801.1 RNA-binding protein 39;RNA-binding motif protein 39;RNA-binding region-containing protein 2;Hepatocellular carcinoma protein 1;Splicing factor HCC1 RBM39;HCC1;RNPC2 Q14498-1;Q14498;Q14498-2 ENST00000253363;ENST00000338163;ENST00000343294 2 0.95109 1.6998 0.9608 1.2093 1.1593 1.2485 Mob1_phocein cell part;intracellular binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding 5 5 5 24 24 24 25.464 2.9275E-06 110230000 57817000 52412000 2913 IPI:IPI00163727.8 Mps one binder kinase activator-like 2A;Mob1 homolog 2A;MOB-LAK;Protein Mob3A MOBKL2A;MOB3A Q96BX8 ENST00000357066 1 0.57188 1.6097 0.74746 0.75319 1.0702 0.99618 Pkinase;RWD;tRNA-synt_2b cell part;cytoplasmic part;cytosolic part;cytosolic ribosome;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome aminoacyl-tRNA ligase activity;binding;catalytic activity;eukaryotic translation initiation factor 2alpha kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;regulation of translation;regulation of translational initiation;tRNA aminoacylation for protein translation;tRNA metabolic process 12 12 12 8.4 8.4 8.4 186.84 3.2366E-23 124230000 67045000 57189000 2914 IPI:IPI00163851.5;IPI:IPI00456685.2 Eukaryotic translation initiation factor 2-alpha kinase 4;GCN2-like protein EIF2AK4;GCN2;KIAA1338 Q9P2K8-1;Q9P2K8;Q9P2K8-2 ENST00000263791;ENST00000382727 K08860 2 0.88731 1.7818 0.88517 1.143 1.2486 1.1301 COG7 cell part;cytoplasmic part;Golgi apparatus part;Golgi membrane;Golgi transport complex;intracellular organelle part;intracellular part;macromolecular complex;membrane;organelle membrane;organelle part;protein complex binding;protein binding carbohydrate metabolic process;cellular process;intracellular protein transport;metabolic process;protein amino acid glycosylation;protein localization;protein modification process;retrograde vesicle-mediated transport, Golgi to ER;transport 7 7 7 10.9 10.9 10.9 86.343 1.3722E-109 89372000 46317000 43055000 2915 IPI:IPI00164005.1 Conserved oligomeric Golgi complex subunit 7;Component of oligomeric Golgi complex 7 COG7;UNQ3082/PRO10013 P83436 ENST00000307149 1 0.37822 7.4627 0.21782 0.49771 4.5347 0.28888 Exo_endo_phos;LRR_1 cell part;cytoplasm;intracellular part binding;catalytic activity;exonuclease activity;hydrolase activity;hydrolase activity, acting on ester bonds;nuclease activity;protein binding cellular biopolymer metabolic process;cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing + 6 6 3 11.9 11.9 5.4 63.001 5.3843E-19 49996000 33631000 16365000 2916 IPI:IPI00164061.2;IPI:IPI00878418.1 CCR4-NOT transcription complex subunit 6-like;Carbon catabolite repressor protein 4 homolog B CNOT6L;CCR4B Q96LI5-1;Q96LI5;Q96LI5-2 ENST00000264903 2 2.4123 4.8093 2.6449 3.303 3.1443 3.4303 NAP cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;chromatin organization;nucleosome assembly;organelle organization 5 5 5 14.2 14.2 14.2 49.306 3.8667E-06 25652000 11135000 14517000 2917 IPI:IPI00164215.5 Testis-specific Y-encoded-like protein 1 TSPYL1;TSPYL Q9H0U9 ENST00000368608 K11284 1 0.63283 1.3377 0.65374 0.79735 0.92112 0.84725 IPPT cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle ATP binding;binding;catalytic activity;nucleoside binding;nucleotide binding;purine nucleoside binding;transferase activity;transferase activity, transferring alkyl or aryl (other than methyl) groups;tRNA isopentenyltransferase activity;zinc ion binding cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;tRNA metabolic process;tRNA processing Zeatin biosynthesis 4 4 4 10.9 10.9 10.9 52.725 3.1077E-38 19394000 11180000 8214100 2918 IPI:IPI00783082.1;IPI:IPI00164286.7;IPI:IPI00513725.1;IPI:IPI00419305.1;IPI:IPI00419306.1 tRNA isopentenyltransferase, mitochondrial;Isopentenyl-diphosphate:tRNA isopentenyltransferase TRIT1;IPT;MOD5 Q9H3H1-1;Q9H3H1;Q9H3H1-4;Q9H3H1-5 ENST00000046894;ENST00000316891;ENST00000372825 K00791 5 NaN NaN 0.58584 NaN NaN 0.75118 zf-C2H2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 3 3 3 1.2 1.2 1.2 304.81 0.0032209 3171600 1666800 1504800 2919 IPI:IPI00164352.6 Zinc finger protein 292 ZNF292;KIAA0530 O60281 ENST00000339907;ENST00000369577 1 0.78438 1.4659 1.3533 1.0204 1.0621 1.6891 Arm;HEAT;IBN_N cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;organelle part;pore complex;protein complex binding;nuclear localization sequence binding;peptide binding;protein binding;protein transporter activity;signal sequence binding;substrate-specific transporter activity;transporter activity anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;protein complex assembly;protein import into nucleus, docking 10 5 5 11.3 6.4 6.4 101.39 1.8092E-24 29475000 14858000 14618000 2920 IPI:IPI00409698.2;IPI:IPI00164417.7 Transportin-2;Karyopherin beta-2b TNPO2 O14787-1;O14787;O14787-2 ENST00000356861 2 0.6712 1.5248 0.75612 0.9635 0.97019 1.0135 dsrm endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;microtubule;non-membrane-bounded organelle;nucleolus;organelle;organelle part binding;double-stranded RNA binding;nucleic acid binding;RNA binding establishment of localization;transport 8 8 8 18.1 18.1 18.1 62.64 1.1351E-75 73201000 39695000 33506000 2921 IPI:IPI00300789.1;IPI:IPI00164481.2;IPI:IPI00640881.1;IPI:IPI00943764.1 Double-stranded RNA-binding protein Staufen homolog 2 STAU2 Q9NUL3-1;Q9NUL3;Q9NUL3-2;Q9NUL3-3;Q9NUL3-4 ENST00000343268;ENST00000355780 4 0.84429 1.5083 0.98866 1.0696 1.0333 1.3017 PID;TBC cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity;Rab GTPase activator activity;Ras GTPase activator activity;small GTPase regulator activity biological regulation;regulation of catalytic activity;regulation of GTPase activity;regulation of hydrolase activity;regulation of molecular function;regulation of Rab GTPase activity;regulation of Ras GTPase activity 9 9 8 8.7 8.7 7.9 133.08 2.7608E-77 34225000 17976000 16250000 2922 IPI:IPI00164610.4 TBC1 domain family member 1 TBC1D1;KIAA1108 Q86TI0 ENST00000261439 1 0.87625 1.4891 0.80416 1.102 0.95647 1.0562 DCP1 cell part;cytoplasmic mRNA processing body;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;ribonucleoprotein complex binding;catalytic activity;hydrolase activity;protein binding mRNA catabolic process;nuclear-transcribed mRNA catabolic process;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA catabolic process 6 6 6 14 14 14 63.436 3.4541E-53 113420000 59923000 53494000 2923 IPI:IPI00164672.6 mRNA-decapping enzyme 1A;Transcription factor SMIF;Smad4-interacting transcriptional co-activator DCP1A;SMIF Q9NPI6 ENST00000294241;ENST00000398650 K01567 1 0.87724 2.0627 0.87867 1.2184 1.272 1.2079 PH;RasGEF cell part;cytoplasm;intracellular part;membrane;plasma membrane binding;enzyme regulator activity;GTPase regulator activity;guanyl-nucleotide exchange factor activity;nucleoside-triphosphatase regulator activity;protein binding biological regulation;cell communication;cellular process;intracellular signaling cascade;regulation of biological process;regulation of cellular process;signal transduction;small GTPase mediated signal transduction 2 2 2 3.6 3.6 3.6 65.166 7.3051E-05 26206000 14495000 11712000 2924 IPI:IPI00334126.1;IPI:IPI00164944.1 Ras-specific guanine nucleotide-releasing factor RalGPS2;RalA exchange factor RalGPS2;Ral GEF with PH domain and SH3-binding motif 2 RALGPS2 Q86X27-1;Q86X27;Q86X27-2 ENST00000367633;ENST00000367635 2 0.75434 1.5078 0.73103 0.95351 1.0277 0.97853 TH1 cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;protein binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 14 14 14 32 32 32 66.246 1.6887E-177 220600000 114780000 105830000 2925 IPI:IPI00164949.3;IPI:IPI00759539.1;IPI:IPI00387090.1 Negative elongation factor C/D;TH1-like protein TH1L;NELFD;TH1;HSPC130 Q8IXH7-1;Q8IXH7;Q8IXH7-4 ENST00000344018 3 0.5824 1.0743 0.5596 0.74018 0.72351 0.73471 Rubis-subs-bind;SET cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;mitochondrion;nucleus;organelle;plasma membrane 11 10 10 18.4 17.3 17.3 67.256 2.0552E-58 109090000 60956000 48135000 2926 IPI:IPI00165026.3;IPI:IPI00395872.2;IPI:IPI00658081.1 SET domain-containing protein 3 SETD3;C14orf154 Q86TU7-1;Q86TU7;Q86TU7-2;Q86TU7-3 ENST00000329331;ENST00000331768 3 0.84064 1.6508 0.9238 1.1333 1.0504 1.1593 SET;zf-MYND cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;lysine N-methyltransferase activity;methyltransferase activity;N-methyltransferase activity;protein binding;protein methyltransferase activity;S-adenosylmethionine-dependent methyltransferase activity;zinc ion binding cellular component organization;cellular process;chromatin modification;chromatin organization;chromosome organization;organelle organization 7 7 7 16.6 16.6 16.6 49.097 5.1051E-10 79458000 39409000 40049000 2927 IPI:IPI00165073.8;IPI:IPI00643755.2;IPI:IPI00514981.3 SET and MYND domain-containing protein 3;Zinc finger MYND domain-containing protein 1 SMYD3;ZMYND1;ZNFN3A1 Q9H7B4-1;Q9H7B4;Q9H7B4-3;Q9H7B4-2 ENST00000327801 K11426 3 0.74172 1.4214 0.61196 0.91922 0.93984 0.83811 tRNA-synt_1b cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-oxygen bonds;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;tyrosine-tRNA ligase activity cellular amino acid and derivative metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;tRNA aminoacylation for protein translation;tRNA metabolic process;tyrosyl-tRNA aminoacylation Aminoacyl-tRNA biosynthesis;Phenylalanine, tyrosine and tryptophan biosynthesis 10 10 10 25.4 25.4 25.4 53.198 1.2062E-235 75547000 40810000 34737000 2928 IPI:IPI00165092.3 Tyrosyl-tRNA synthetase, mitochondrial;Tyrosine--tRNA ligase YARS2;CGI-04 Q9Y2Z4 ENST00000324868 K01866 1 0.76768 1.3953 0.7552 1.0331 0.92367 0.99162 RRM_1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;nucleotide binding;RNA binding cell differentiation;cellular developmental process;cellular process;developmental process;gamete generation;male gamete generation;multicellular organismal development;multicellular organismal process;reproductive process;spermatogenesis 8 8 8 31.2 31.2 31.2 43.383 7.1589E-268 540110000 281400000 258710000 2931 IPI:IPI00165230.1;IPI:IPI00335930.1 DAZ-associated protein 1;Deleted in azoospermia-associated protein 1 DAZAP1 Q96EP5-1;Q96EP5;Q96EP5-2 ENST00000233078;ENST00000336761;ENST00000395533 2 0.80681 1.6659 0.84132 1.0791 1.0781 1.0861 Sec1 endoplasmic reticulum membrane;Golgi cisterna membrane;Golgi membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane part;membrane-bounded organelle;nucleus;organelle;organelle membrane;organelle part cellular process;establishment of localization;establishment of protein localization;membrane docking;protein transport;transport;vesicle docking;vesicle docking during exocytosis 13 13 13 27.4 27.4 27.4 72.379 0 403460000 192480000 210980000 2932 IPI:IPI00165261.6 Sec1 family domain-containing protein 1;Syntaxin-binding protein 1-like 2;Sly1p SCFD1;C14orf163;KIAA0917;STXBP1L2;FKSG23 Q8WVM8 ENST00000311943 1 0.68138 1.3223 0.64526 0.86149 0.92753 0.79234 TPR_1 intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;microbody;microbody membrane;microbody part;organelle;organelle membrane;organelle part;peroxisomal membrane;peroxisomal part binding;protein binding establishment of localization;establishment of protein localization;protein transport;transport 6 6 6 13.9 13.9 13.9 70.864 1.1029E-46 74857000 39958000 34899000 2933 IPI:IPI00384805.3;IPI:IPI00165272.5;IPI:IPI00032931.2 Peroxisomal targeting signal 1 receptor;Peroxisome receptor 1;Peroxisomal C-terminal targeting signal import receptor;PTS1-BP;Peroxin-5 PEX5;PXR1 P50542-1;P50542;P50542-3;P50542-2 ENST00000266563;ENST00000266564;ENST00000396637 3 0.82285 1.4472 0.91644 1.0229 1.0585 1.135 BAH;ELM2;GATA;Myb_DNA-binding cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;sequence-specific DNA binding;transcription factor activity;transcription regulator activity;transition metal ion binding;zinc ion binding regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent 9 3 3 17.3 6.1 6.1 67.503 8.3937E-124 41163000 19781000 21382000 2934 IPI:IPI00165357.4;IPI:IPI00220288.3 Metastasis-associated protein MTA3 MTA3;KIAA1266 Q9BTC8-1;Q9BTC8;Q9BTC8-2 ENST00000405094 K11660 2 0.70049 1.4503 0.71197 0.95311 0.98144 0.86528 Rhodanese cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle 3-mercaptopyruvate sulfurtransferase activity;catalytic activity;sulfurtransferase activity;thiosulfate sulfurtransferase activity;transferase activity;transferase activity, transferring sulfur-containing groups anion transport;catabolic process;cellular process;cyanate catabolic process;cyanate metabolic process;ion transport;metabolic process;nitrogen compound metabolic process;organic acid metabolic process;response to toxin;sulfate transport;transport Cysteine metabolism 8 8 8 40.4 40.4 40.4 33.178 4.6732E-156 191710000 97963000 93746000 2935 IPI:IPI00165360.5 3-mercaptopyruvate sulfurtransferase MPST;TST2 P25325 ENST00000341116;ENST00000397129;ENST00000397225;ENST00000401419;ENST00000402334;ENST00000404802 K01011 1 0.7197 1.3799 0.7314 0.99893 0.89031 0.91759 DUF298 9 9 9 32.9 32.9 32.9 27.508 7.5923E-73 316470000 226770000 89708000 2936 IPI:IPI00165361.3;IPI:IPI00941798.1;IPI:IPI00385380.2 DCN1-like protein 5;Defective in cullin neddylation protein 1-like protein 5;DCUN1 domain-containing protein 5 DCUN1D5 Q9BTE7 ENST00000260247 3 0.71229 1.4106 0.7374 0.96954 0.95059 0.9299 LRR_1 cell part;cytoplasmic membrane-bounded vesicle;cytoplasmic part;cytoplasmic vesicle;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;membrane-bounded vesicle;nucleus;organelle;vesicle binding;enzyme inhibitor activity;enzyme regulator activity;phosphatase inhibitor activity;phosphatase regulator activity;protein binding;protein phosphatase regulator activity 6 6 6 25.7 25.7 25.7 30.692 3.1506E-293 676330000 364050000 312280000 2937 IPI:IPI00165393.1 Acidic leucine-rich nuclear phosphoprotein 32 family member E;LANP-like protein ANP32E Q9BTT0 ENST00000314136 1 0.5532 1.0149 0.52686 0.73417 0.67488 0.68753 Acetyltransf_1;Radical_SAM cytoplasm;DNA-directed RNA polymerase II, holoenzyme;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nucleolus;organelle;protein complex;transcription elongation factor complex acetyltransferase activity;acyltransferase activity;binding;catalytic activity;histone acetyltransferase activity;iron ion binding;lysine N-acetyltransferase activity;N-acetyltransferase activity;phosphorylase kinase regulator activity;protein binding metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 10 10 10 24.1 24.1 24.1 62.258 2.3507E-58 48187000 26657000 21530000 2939 IPI:IPI00165477.6;IPI:IPI00844099.1;IPI:IPI00844135.1 Elongator complex protein 3 ELP3 Q9H9T3-1;Q9H9T3;Q9H9T3-2;Q9H9T3-3 ENST00000256398;ENST00000380353 K07739 3 0.84683 1.4359 0.81465 1.1161 0.92975 1.0307 DUF525;YccV-like cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;mitochondrial nucleoid;mitochondrial part;nucleoid;nucleus;organelle;organelle part 17 17 17 50.8 50.8 50.8 42.033 1.0299E-202 572180000 301020000 271160000 2940 IPI:IPI00165506.4 Polymerase delta-interacting protein 2;38 kDa DNA polymerase delta interaction protein;p38 POLDIP2;PDIP38;POLD4;HSPC017 Q9Y2S7 ENST00000003607 1 0.86655 1.8402 0.8818 1.0881 1.1633 1.0948 DUF1692 endoplasmic reticulum membrane;ER-Golgi intermediate compartment membrane;Golgi apparatus;integral to membrane;intracellular organelle;intrinsic to membrane;membrane;membrane-bounded organelle;nucleus;organelle;organelle membrane cellular process;establishment of localization;transport;vesicle-mediated transport 3 3 3 8.8 8.8 8.8 43.494 1.0235E-06 20658000 11513000 9145200 2943 IPI:IPI00165651.1 Endoplasmic reticulum-Golgi intermediate compartment protein 2 ERGIC2;ERV41;PTX1;CDA14 Q96RQ1 ENST00000201023;ENST00000360150 1 0.62012 1.5327 0.67652 0.82022 0.98961 0.90884 cell part;intracellular organelle part;intracellular part;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part 2 2 2 2.9 2.9 2.9 92.576 4.1783E-07 24634000 13460000 11174000 2946 IPI:IPI00165995.6 Splicing factor, arginine/serine-rich 18;Splicing factor, arginine/serine-rich 130;Serine-arginine-rich-splicing regulatory protein 130;SR-related protein SFRS18;C6orf111;SRRP130;HSPC261;HSPC306 Q8TF01-1;Q8TF01 ENST00000369239 1 0.50923 1.1398 0.55215 0.64098 0.81843 0.70404 F-box;JmjC;zf-CXXC cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;DNA binding;iron ion binding;nucleic acid binding;oxidoreductase activity;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen;protein binding;zinc ion binding chromatin organization;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;proteolysis;regulation of transcription, DNA-dependent;transcription 5 5 5 6.5 6.5 6.5 132.79 1.1036E-43 83723000 47305000 36417000 2947 IPI:IPI00166009.2;IPI:IPI00739880.1;IPI:IPI00737083.1 Lysine-specific demethylase 2A;JmjC domain-containing histone demethylation protein 1A;[Histone-H3]-lysine-36 demethylase 1A;F-box/LRR-repeat protein 11;F-box and leucine-rich repeat protein 11;F-box protein FBL7;F-box protein Lilina;CXXC-type zinc finger protein 8 KDM2A;CXXC8;FBL7;FBXL11;JHDM1A;KIAA1004 Q9Y2K7-1;Q9Y2K7;Q9Y2K7-2 ENST00000308783;ENST00000398645;ENST00000401583 K10277 3 0.84717 1.5597 0.78366 1.1014 1.0478 1.0184 Not1 biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 54 54 54 27.3 27.3 27.3 266.94 0 1081300000 603750000 477510000 2948 IPI:IPI00166010.6;IPI:IPI00880052.1;IPI:IPI00642900.2;IPI:IPI00410157.4 CCR4-NOT transcription complex subunit 1;Negative regulator of transcription subunit 1 homolog;CCR4-associated factor 1 CNOT1;CDC39;KIAA1007;NOT1;AD-005 A5YKK6-1;A5YKK6;A5YKK6-2;A5YKK6-3;A5YKK6-4 ENST00000317147;ENST00000394200 4 0.57228 1.0576 NaN 0.79151 0.67307 NaN AAR2 6 6 6 21.1 21.1 21.1 43.472 2.1051E-187 13319000 7473700 5845300 2949 IPI:IPI00166013.1 Uncharacterized protein C20orf4 C20orf4;CGI-23;PRO0225 Q9Y312 ENST00000320849;ENST00000373932;ENST00000397286 1 0.45291 1.0317 0.41724 0.60881 0.70218 0.58429 HEAT;WD40 cell part;cytoplasmic part;cytosol;intracellular part binding Insulin signaling pathway;mTOR signaling pathway 5 5 5 3.8 3.8 3.8 149.04 3.9247E-16 26874000 14679000 12195000 2950 IPI:IPI00166044.1;IPI:IPI00410411.4 Regulatory-associated protein of mTOR;P150 target of rapamycin (TOR)-scaffold protein RPTOR;KIAA1303;RAPTOR Q8N122-1;Q8N122;Q8N122-2 ENST00000306801 K07204 2 0.69264 1.2946 0.8463 0.94466 0.8743 1.1265 ORMDL cell part;cytoplasmic part;endoplasmic reticulum;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane part;membrane-bounded organelle;organelle 3 3 1 21.6 21.6 9.8 17.494 4.4002E-69 64385000 32695000 31690000 2952 IPI:IPI00166066.1;IPI:IPI00654634.1 ORM1-like protein 3 ORMDL3 Q8N138-1;Q8N138;Q8N138-4 ENST00000304046;ENST00000394169 2 0.7133 1.7845 0.73856 0.94508 1.1585 1.0042 VKOR cell part;integral to membrane;intrinsic to membrane;membrane part 2 2 2 11.9 11.9 11.9 19.835 3.5583E-08 52313000 28103000 24211000 2953 IPI:IPI00166079.4 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 Q8N0U8 ENST00000360768 1 0.70848 1.3022 0.62675 0.94271 0.83838 0.79925 TPR_1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding cellular process;cellular response to stress;DNA metabolic process;DNA repair;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to DNA damage stimulus;response to stress 11 11 11 30.2 30.2 30.2 48.927 1.2331E-98 76408000 40233000 36175000 2954 IPI:IPI00166123.4 Tetratricopeptide repeat protein 5 TTC5 Q8N0Z6 ENST00000258821 1 NaN 1.3755 NaN NaN 0.98153 NaN Vps52 cytoplasmic part;endosomal part;endosome membrane;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;organelle;organelle membrane;organelle part establishment of localization;establishment of protein localization;protein transport;transport 2 2 2 3.2 3.2 3.2 82.22 1.6935E-21 1485800 798300 687490 2955 IPI:IPI00166132.3 Vacuolar protein sorting-associated protein 52 homolog;SAC2 suppressor of actin mutations 2-like protein VPS52;SACM2L Q8N1B4 ENST00000293739;ENST00000383078;ENST00000383210 1 0.45126 0.9831 0.48166 0.56793 0.65098 0.63153 FtsJ;G-patch;WW cell part;intracellular binding;catalytic activity;methyltransferase activity;nucleic acid binding;protein binding;transferase activity;transferase activity, transferring one-carbon groups cellular metabolic process;cellular process;metabolic process;methylation;one-carbon metabolic process 4 4 4 5 5 5 95.32 8.989E-15 11207000 6678000 4528500 2956 IPI:IPI00166153.3 FtsJ methyltransferase domain-containing protein 2 FTSJD2;KIAA0082 Q8N1G2 ENST00000373451 1 0.88201 1.8714 0.98045 1.1223 1.2693 1.2367 Acyltransferase cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part 1-acylglycerol-3-phosphate O-acyltransferase activity;acylglycerol O-acyltransferase activity;acyltransferase activity;catalytic activity;O-acyltransferase activity;transferase activity;transferase activity, transferring acyl groups biosynthetic process;cellular process;lipid biosynthetic process;lipid metabolic process;metabolic process;multicellular organismal development;organophosphate metabolic process;phospholipid biosynthetic process;phospholipid metabolic process 1- and 2-Methylnaphthalene degradation;Benzoate degradation via CoA ligation;Ether lipid metabolism;Ethylbenzene degradation;Glycerolipid metabolism;Glycerophospholipid metabolism;Limonene and pinene degradation;Phenylalanine metabolism;Tyrosine metabolism 3 3 3 7.5 7.5 7.5 48.92 3.2136E-08 33414000 16331000 17083000 2958 IPI:IPI00419643.1;IPI:IPI00166225.1 Lysocardiolipin acyltransferase 1;Acyl-CoA:lysocardiolipin acyltransferase 1;1-acylglycerol-3-phosphate O-acyltransferase 8 LCLAT1;AGPAT8;ALCAT1;LYCAT;UNQ1849/PRO3579 Q6UWP7-1;Q6UWP7;Q6UWP7-2 ENST00000309052;ENST00000359433 K00655;K00680 2 0.72493 1.6249 0.73765 0.97176 1.0292 0.98002 DUF634 cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part binding biological regulation;regulation of biological process;regulation of growth 4 4 4 13.4 13.4 13.4 37.54 4.6048E-46 22264000 12552000 9712600 2960 IPI:IPI00166394.1;IPI:IPI00420025.2;IPI:IPI00217968.1;IPI:IPI00855858.1 Armadillo repeat-containing protein 10;Splicing variant involved in hepatocarcinogenesis protein ARMC10;SVH;PSEC0198 Q8N2F6-1;Q8N2F6;Q8N2F6-2;Q8N2F6-3;Q8N2F6-4 ENST00000306450;ENST00000323716;ENST00000323735 4 0.93463 1.4343 0.79049 1.1316 1.0232 1.0235 AMP-binding cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle acid-thiol ligase activity;adenyl nucleotide binding;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-sulfur bonds;nucleoside binding;nucleotide binding;purine nucleoside binding;purine nucleotide binding carboxylic acid metabolic process;cellular ketone metabolic process;cellular process;fatty acid metabolic process;lipid metabolic process;metabolic process;monocarboxylic acid metabolic process;organic acid metabolic process;oxoacid metabolic process 18 18 18 38.9 38.9 38.9 64.113 2.0053E-249 345800000 178160000 167640000 2961 IPI:IPI00166395.4;IPI:IPI00450347.2 Acyl-CoA synthetase family member 3, mitochondrial ACSF3;PSEC0197 Q4G176-1;Q4G176;Q4G176-2 ENST00000317447;ENST00000393145;ENST00000406948 2 NaN 0.57218 NaN NaN 0.36136 NaN SAP;zf-MIZ acid-amino acid ligase activity;binding;catalytic activity;DNA binding;ion binding;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleic acid binding;small conjugating protein ligase activity;SUMO ligase activity;zinc ion binding catabolic process;cell communication;cell surface receptor linked signal transduction;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;proteolysis;signal transduction;transcription Jak-STAT signaling pathway;Pathways in cancer;Small cell lung cancer;Ubiquitin mediated proteolysis 2 2 2 6.1 6.1 6.1 56.503 5.1821E-85 379830 125910 253920 2962 IPI:IPI00166500.3 E3 SUMO-protein ligase PIAS4;Protein inhibitor of activated STAT protein 4;Protein inhibitor of activated STAT protein gamma;PIASy PIAS4;PIASG Q8N2W9 ENST00000262971 K04706 1 0.87029 1.3252 NaN 1.0775 0.96365 NaN RasGEF_N cell part;intracellular part;macromolecular complex;protein complex;TORC2 complex binding;enzyme regulator activity;GTPase regulator activity;guanyl-nucleotide exchange factor activity;nucleoside-triphosphatase regulator activity;protein binding actin filament-based process;cellular component organization;cellular process;cytoskeleton organization;embryonic development;organelle organization;regulation of cell communication;regulation of protein kinase cascade;regulation of signal transduction mTOR signaling pathway 4 4 4 2.4 2.4 2.4 195.01 2.3771E-14 11437000 6319100 5118200 2963 IPI:IPI00166528.4;IPI:IPI00455500.1;IPI:IPI00868848.1 Rapamycin-insensitive companion of mTOR;mAVO3 RICTOR;KIAA1999 Q6R327-3;Q6R327;Q6R327-1;Q6R327-4 ENST00000357387 K08267 3 0.79603 1.6376 0.96926 1.0108 1.1536 1.1775 4 4 4 27.8 27.8 27.8 23.889 7.4676E-82 14978000 8440500 6537200 2965 IPI:IPI00166638.3;IPI:IPI00430781.1 UPF0598 protein C8orf82 C8orf82 Q6P1X6-1;Q6P1X6;Q6P1X6-2 ENST00000313465 2 0.59359 1.9621 0.63559 0.89936 1.0822 0.94853 cytoplasmic part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;macromolecular complex;membrane part;mitochondrial outer membrane translocase complex;mitochondrial part;organelle part;protein complex establishment of localization;establishment of protein localization;intracellular protein transport;intracellular transport;mitochondrial transport;protein import;protein targeting;protein targeting to mitochondrion;protein transport;transport 2 2 2 29.4 29.4 29.4 6.0352 1.3502E-16 83596000 44667000 38928000 2966 IPI:IPI00166704.1 Mitochondrial import receptor subunit TOM5 homolog TOMM5;C9orf105;TOM5 Q8N4H5 ENST00000321301;ENST00000377773 1 0.69359 1.8224 0.56534 1.012 1.0992 0.82614 KH_1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding;protein domain specific binding;SH3 domain binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 3 1 1 7.4 3.2 3.2 38.927 0.0010417 58354000 30940000 27414000 2967 IPI:IPI00166708.2 KH domain-containing, RNA-binding, signal transduction-associated protein 2;Sam68-like mammalian protein 1 KHDRBS2;SLM1 Q5VWX1 ENST00000281156 1 0.044371 13.397 NaN 0.05898 8.5637 NaN C1-set;MHC_I cell part;extracellular region;macromolecular complex;membrane part;MHC class I protein complex;MHC protein complex;plasma membrane part;protein complex binding;catalytic activity;fatty acid binding;hydrolase activity;lipid binding;nuclease activity;protein binding;protein transmembrane transporter activity;protein transporter activity;ribonuclease activity;transporter activity antigen processing and presentation;biological adhesion;catabolic process;cell adhesion;cellular process;immune response;immune system process;lipid catabolic process;lipid metabolic process;metabolic process;negative regulation of cell proliferation + 9 9 9 39.6 39.6 39.6 34.258 4.4591E-71 23764000 23442000 321760 2968 IPI:IPI00166729.4;IPI:IPI00871622.2 Zinc-alpha-2-glycoprotein;Zn-alpha-2-glycoprotein AZGP1;ZAG;ZNGP1 P25311 ENST00000292401 2 0.43032 NaN NaN 0.55894 NaN NaN ADH_N;ADH_zinc_N binding;catalytic activity;cation binding;ion binding;metal ion binding;oxidoreductase activity;transition metal ion binding;zinc ion binding metabolic process;oxidation reduction 3 3 3 9.8 9.8 9.8 40.14 2.3478E-07 2614200 1612200 1002000 2969 IPI:IPI00166738.1 Zinc-binding alcohol dehydrogenase domain-containing protein 2 ZADH2 Q8N4Q0 ENST00000322342 K07119 1 0.83517 1.7662 0.73525 1.0947 1.1711 0.95231 cell part;integral to membrane;intrinsic to membrane;membrane part 2 2 2 11.5 11.5 11.5 23.13 2.1887E-06 56774000 29213000 27561000 2970 IPI:IPI00166746.3 Transmembrane protein 199 TMEM199;C17orf32 Q8N511 ENST00000292114 1 0.80443 1.3484 0.78944 1.0111 0.93699 1.0258 Peptidase_M16;Peptidase_M16_C cell part;cytoplasmic part;intracellular organelle part;intracellular part;membrane;mitochondrial inner membrane;mitochondrial matrix;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part binding;catalytic activity;cation binding;endopeptidase activity;hydrolase activity;ion binding;metal ion binding;metalloendopeptidase activity;metallopeptidase activity;peptidase activity;protein binding;transition metal ion binding;zinc ion binding biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis 14 14 14 34.9 34.9 34.9 58.252 1.3269E-182 821190000 421910000 399290000 2971 IPI:IPI00166749.3 Mitochondrial-processing peptidase subunit alpha;Alpha-MPP;P-55 PMPCA;INPP5E;KIAA0123;MPPA Q10713 ENST00000371717 K01412 1 0.68485 1.2337 0.51446 0.84089 0.84464 0.83075 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;cation binding;ion binding;ligase activity;metal ion binding;transition metal ion binding;zinc ion binding catabolic process;DNA metabolic process;DNA recombination;DNA repair;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;proteolysis;response to DNA damage stimulus;response to stress 5 5 5 16.2 16.2 16.2 27.932 3.9206E-11 30094000 16792000 13302000 2972 IPI:IPI00166784.2 E3 SUMO-protein ligase NSE2;Non-structural maintenance of chromosomes element 2 homolog NSMCE2;C8orf36;MMS21 Q96MF7 ENST00000287437 1 0.77696 1.6085 0.80838 0.94404 1.0216 0.99485 Tmemb_32 early endosome membrane;endoplasmic reticulum membrane;endoplasmic reticulum part;endosome membrane;Golgi apparatus part;Golgi membrane;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part binding;cation transmembrane transporter activity;di-, tri-valent inorganic cation transmembrane transporter activity;ion transmembrane transporter activity;magnesium ion binding;magnesium ion transmembrane transporter activity;transporter activity cation transport;di-, tri-valent inorganic cation transport;divalent metal ion transport;establishment of localization;ion transport;magnesium ion transport;metal ion transport;transport 2 2 2 17.9 17.9 17.9 21.881 2.431E-16 52765000 28398000 24367000 2973 IPI:IPI00166785.2;IPI:IPI00922265.1 Membrane magnesium transporter 1;Transmembrane protein 32 MMGT1;TMEM32 Q8N4V1-2;Q8N4V1;Q8N4V1-1 ENST00000305963 2 NaN NaN 0.92706 NaN NaN 1.1566 DUF1232;zf-C3HC4 cell part;integral to membrane;intrinsic to membrane;membrane part binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding 2 2 2 11.5 11.5 11.5 22.154 0.00094631 18121000 5623000 12499000 2975 IPI:IPI00166853.4;IPI:IPI00742872.3;IPI:IPI00829735.1;IPI:IPI00829763.1 RING finger protein 170;Putative LAG1-interacting protein RNF170 Q96K19-3;Q96K19;Q96K19-1;Q96K19-2;Q96K19-5 ENST00000240159;ENST00000319073;ENST00000319104;ENST00000330830 4 0.45051 NaN 0.50169 0.55766 NaN 0.64744 2 2 2 14.9 14.9 14.9 20.464 1.6715E-63 13712000 7992200 5719800 2976 IPI:IPI00166861.3 Uncharacterized protein C12orf45 C12orf45 Q8N5I9 ENST00000280749 1 0.74303 1.6636 0.81483 1.0005 1.1195 1.0824 MitoNEET_N;zf-CDGSH cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular part;intrinsic to membrane;macromolecular complex;membrane;membrane part;organelle membrane;organelle part;protein complex 2 iron, 2 sulfur cluster binding;binding;cation binding;ion binding;iron ion binding;iron-sulfur cluster binding;metal cluster binding;metal ion binding;transition metal ion binding 5 5 5 41.5 41.5 41.5 15.278 1.5565E-106 199390000 106830000 92566000 2977 IPI:IPI00166865.3 CDGSH iron sulfur domain-containing protein 2;Endoplasmic reticulum intermembrane small protein;MitoNEET-related 1 protein CISD2;CDGSH2;ERIS;ZCD2 Q8N5K1 ENST00000273986 1 0.69142 1.1526 0.8093 0.83938 0.82075 0.9961 Ets cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;protein binding;sequence-specific DNA binding;transcription activator activity;transcription factor activity;transcription regulator activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 5 5 5 13.2 13.2 13.2 67.497 6.9954E-98 58505000 29399000 29106000 2979 IPI:IPI00167002.3 ETS-related transcription factor Elf-1;E74-like factor 1 ELF1 P32519 ENST00000239882;ENST00000379498 K09428 1 1.1598 1.9673 0.64101 1.4775 1.3747 0.91867 TYW3 catalytic activity;methyltransferase activity;transferase activity;transferase activity, transferring one-carbon groups cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;tRNA metabolic process;tRNA processing 4 4 4 20.5 20.5 20.5 29.794 6.2931E-21 24721000 13218000 11503000 2982 IPI:IPI00167237.5 tRNA wybutosine-synthesizing protein 3 homolog;tRNA-yW-synthesizing protein 3 TYW3;C1orf171 Q6IPR3 ENST00000370867 1 1.0421 NaN NaN 1.4058 NaN NaN TPR_1;TPR_2 cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex binding;protein binding metabolic process;N-terminal protein amino acid acetylation;positive regulation of biosynthetic process;protein amino acid acetylation;protein modification process;regulation of biosynthetic process;regulation of transcription, DNA-dependent 5 1 1 6.1 1.9 1.9 101.46 3.1048E-29 33613 14833 18780 2983 IPI:IPI00167368.2;IPI:IPI00478058.2;IPI:IPI00513890.1;IPI:IPI00514816.1 NMDA receptor-regulated 1-like protein NARG1L;NAT2 Q6N069-1;Q6N069;Q6N069-2;Q6N069-3;Q6N069-4 ENST00000325763;ENST00000379367;ENST00000379406 4 0.86706 1.8278 0.82692 1.1932 1.2687 1.1093 Ank binding;protein binding 11 11 10 12.2 12.2 10.3 107.77 9.8712E-53 101450000 55176000 46272000 2984 IPI:IPI00167419.9;IPI:IPI00761054.2;IPI:IPI00395999.5;IPI:IPI00477624.3;IPI:IPI00915264.1 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B;Ankyrin repeat domain-containing protein 44 ANKRD44 Q8N8A2-2;Q8N8A2;Q8N8A2-1;Q8N8A2-4;Q8N8A2-3 ENST00000282272 5 0.50068 1.4758 NaN 0.71351 0.91348 NaN 60KD_IMP integral to membrane;integral to mitochondrial inner membrane;integral to mitochondrial membrane;integral to organelle membrane;intrinsic to membrane;intrinsic to mitochondrial inner membrane;intrinsic to organelle membrane;organelle part protein transporter activity;substrate-specific transporter activity;transporter activity anatomical structure formation;cellular component organization;cellular process;mitochondrial membrane organization;mitochondrion organization;organelle organization;protein complex assembly;protein localization;respiratory chain complex IV assembly 2 2 2 7.8 7.8 7.8 37.133 0.00029221 4513400 2552600 1960800 2985 IPI:IPI00167538.3 Mitochondrial inner membrane protein COX18;Cytochrome c oxidase assembly protein 18;COX18Hs COX18;OXA1L2 Q8N8Q8-1;Q8N8Q8 ENST00000295890 1 0.79761 1.6398 0.775 1.0066 1.1181 0.99043 DUF2465 binding;protein binding 10 9 9 36.4 32.1 32.1 37.19 9.2525E-118 365450000 207590000 157860000 2986 IPI:IPI00167572.4 Protein FAM98B FAM98B Q52LJ0 ENST00000305752;ENST00000397609 1 0.64584 1.3687 0.75014 0.87402 0.88456 0.98676 GTP1_OBG;MMR_HSR1 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cellular component biogenesis;cellular process;ribonucleoprotein complex biogenesis;ribosome biogenesis 4 4 4 12.9 12.9 12.9 42.932 1.2928E-17 35915000 19838000 16077000 2988 IPI:IPI00167638.4;IPI:IPI00217526.2 GTP-binding protein 10;Protein obg homolog 2 GTPBP10;OBGH2;UG0751c10 A4D1E9-1;A4D1E9;A4D1E9-2 ENST00000222511;ENST00000257659;ENST00000380058 2 NaN 1.5866 0.55073 NaN 1.0041 0.80371 3 3 3 11.4 11.4 11.4 44.746 6.0039E-06 24491000 12939000 11552000 2990 IPI:IPI00167762.2;IPI:IPI00395792.1;IPI:IPI00847400.1 Uncharacterized protein C19orf47 C19orf47 Q8N9M1-1;Q8N9M1;Q8N9M1-2;Q8N9M1-3 ENST00000357884;ENST00000392035 3 0.7674 1.0826 NaN 0.97309 0.73623 NaN BEN cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding cell cycle;chromatin organization;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;regulation of transcription, DNA-dependent;transcription 2 2 2 5.2 5.2 5.2 56.484 1.0093E-07 2183900 1159200 1024700 2991 IPI:IPI00167773.2;IPI:IPI00218489.2;IPI:IPI00332572.3 Protein BANP;Btg3-associated nuclear protein;Scaffold/matrix-associated region-1-binding protein;BEN domain-containing protein 1 BANP;BEND1;SMAR1 Q8N9N5-1;Q8N9N5;Q8N9N5-2;Q8N9N5-3 ENST00000286122;ENST00000355022;ENST00000355163;ENST00000393207 3 0.57198 1.0602 0.42589 0.71624 0.67535 0.55545 Peptidase_M14 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;carboxypeptidase activity;catalytic activity;cation binding;exopeptidase activity;hydrolase activity;ion binding;metallocarboxypeptidase activity;metalloexopeptidase activity;metallopeptidase activity;peptidase activity;zinc ion binding biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis 5 5 5 4.4 4.4 4.4 138.45 5.0198E-21 2699200 1303800 1395400 2992 IPI:IPI00167865.2;IPI:IPI00942428.1 Cytosolic carboxypeptidase 1;ATP/GTP-binding protein 1;Nervous system nuclear protein induced by axotomy AGTPBP1;CCP1;KIAA1035;NNA1 Q9UPW5-1;Q9UPW5;Q9UPW5-2 ENST00000337006;ENST00000357081;ENST00000395847 2 0.48164 0.74955 0.42562 0.6245 0.49617 0.52609 HELP;WD40 cell part;cytoplasm;cytoskeletal part;intracellular organelle part;intracellular part;microtubule;organelle part binding;protein binding 5 5 5 6.7 6.7 6.7 95.196 1.2753E-17 17515000 10870000 6644600 2993 IPI:IPI00167909.5;IPI:IPI00843902.1;IPI:IPI00843958.1 Echinoderm microtubule-associated protein-like 3 EML3 Q32P44-1;Q32P44;Q32P44-3;Q32P44-2 ENST00000278845;ENST00000394773;ENST00000394776 3 0.44226 0.82577 0.50985 0.56077 0.55967 0.63706 AAA_5 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity anatomical structure formation;cellular component assembly;cellular component organization;macromolecular complex subunit organization;protein complex assembly;regulation of cellular component biogenesis;regulation of protein complex assembly 55 55 54 12.5 12.5 12.4 632.81 0 429370000 240940000 188430000 2994 IPI:IPI00167941.1 Midasin;MIDAS-containing protein MDN1;KIAA0301 Q9NU22 ENST00000369393 1 0.82619 1.4083 0.89199 0.98923 1.0106 1.1592 UCH catalytic activity;cysteine-type peptidase activity;hydrolase activity;hydrolase activity, acting on ester bonds;peptidase activity;peptidase activity, acting on L-amino acid peptides;thiolester hydrolase activity;ubiquitin thiolesterase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process 4 4 4 5.2 5.2 5.2 116.54 2.5098E-68 8053000 4075600 3977400 2997 IPI:IPI00168084.2 Ubiquitin carboxyl-terminal hydrolase 38;Ubiquitin thioesterase 38;Ubiquitin-specific-processing protease 38;Deubiquitinating enzyme 38;HP43.8KD USP38;KIAA1891 Q8NB14 ENST00000307017 K11854 1 0.67612 1.1336 0.67122 0.87396 0.79403 0.87582 DJ-1_PfpI extracellular region 3 3 3 16 16 16 26.784 3.1705E-56 73014000 40922000 32092000 2998 IPI:IPI00719079.1;IPI:IPI00168112.2;IPI:IPI00167976.1;IPI:IPI00443655.1 Parkinson disease 7 domain-containing protein 1 PDDC1 Q8NB37-2;Q8NB37;Q8NB37-1;Q8NB37-3 ENST00000319863;ENST00000354286;ENST00000397472 4 0.46509 1.3225 0.46743 0.6278 0.85126 0.66884 DTW 6 6 6 25.5 25.5 25.5 33.415 1.469E-82 17077000 10734000 6343600 2999 IPI:IPI00168209.3 DTW domain-containing protein 2 DTWD2 Q8NBA8 ENST00000304058 1 0.76597 1.094 0.7434 0.96566 0.78228 0.94214 Glyco_transf_25 endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;membrane-enclosed lumen;organelle;organelle lumen;organelle part catalytic activity;transferase activity;transferase activity, transferring glycosyl groups biosynthetic process;carbohydrate metabolic process;lipid biosynthetic process;lipid metabolic process;lipopolysaccharide metabolic process;metabolic process;polysaccharide biosynthetic process;polysaccharide metabolic process 7 7 7 11.3 11.3 11.3 71.635 2.9584E-35 188260000 92926000 95332000 3000 IPI:IPI00168262.2 Glycosyltransferase 25 family member 1 GLT25D1;PSEC0241 Q8NBJ5 ENST00000252599 K11703 1 0.79524 1.4812 0.72032 1.0184 1.0261 0.93616 UBA cell part;integral to membrane;intrinsic to membrane;membrane part 8 8 8 29.7 29.7 29.7 38.963 2.492E-62 50206000 25963000 24242000 3001 IPI:IPI00168284.2;IPI:IPI00007034.3;IPI:IPI00829996.1;IPI:IPI00941744.1;IPI:IPI00829931.1 Ubiquitin-associated domain-containing protein 2;Phosphoglycerate dehydrogenase-like protein 1 UBAC2;PHGDHL1;PSEC0110 Q8NBM4-1;Q8NBM4;Q8NBM4-2;Q8NBM4-3;Q8NBM4-4 ENST00000325028;ENST00000355700;ENST00000376435;ENST00000403766 5 0.6214 1.0245 0.74788 0.76604 0.74203 1.0259 Spc24 condensed chromosome kinetochore;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;kinetochore;macromolecular complex;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle binding;protein binding cell cycle phase;cell cycle process;cell division;cellular component organization;cellular process;mitosis;nuclear division;organelle fission;organelle organization 2 2 2 15.7 15.7 15.7 22.443 8.9347E-08 29873000 17491000 12382000 3002 IPI:IPI00168317.1 Kinetochore protein Spc24 SPC24;SPBC24 Q8NBT2 ENST00000293743 K11549 1 1.0546 1.5879 0.69935 1.3035 1.0524 0.85754 LEM;MAN1_C integral to membrane;integral to nuclear inner membrane;integral to organelle membrane;intracellular part;intrinsic to membrane;intrinsic to nuclear inner membrane;intrinsic to organelle membrane;membrane part;nuclear part;organelle part 4 4 4 8.2 8.2 8.2 56.974 4.6501E-19 71589000 34805000 36784000 3003 IPI:IPI00168336.1 LEM domain-containing protein 2 LEMD2 Q8NC56 ENST00000293760 1 0.86226 1.7192 0.8579 1.13 1.1424 1.1331 endoplasmic reticulum;intracellular organelle;macromolecular complex;membrane-bounded organelle;non-membrane-bounded organelle;nucleolus;organelle;ribonucleoprotein complex;ribosome;signal recognition particle, endoplasmic reticulum targeting binding;nucleic acid binding;RNA binding Protein export 29 29 29 50.1 50.1 50.1 70.729 0 1070800000 538830000 531960000 3004 IPI:IPI00168388.1;IPI:IPI00102936.3 Signal recognition particle 68 kDa protein SRP68 Q9UHB9-1;Q9UHB9;Q9UHB9-2 ENST00000304220;ENST00000307877 K03107 2 1.0004 1.7454 0.87415 1.2837 1.2121 1.1465 DAO;GCV_T;GCV_T_C cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part aminomethyltransferase activity;catalytic activity;methyltransferase activity;oxidoreductase activity;transferase activity;transferase activity, transferring one-carbon groups catabolic process;cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;glycine catabolic process;glycine metabolic process;metabolic process;nitrogen compound metabolic process;organic acid metabolic process 14 14 14 18.4 18.4 18.4 99.363 3.2641E-129 179210000 94649000 84562000 3005 IPI:IPI00168407.3 Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial PDPR;KIAA1990 Q8NCN5 ENST00000288050 1 1.8634 3.4046 1.7683 2.5234 2.1975 2.364 RRM_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;nucleotide binding;RNA binding cellular biopolymer metabolic process;cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing 4 2 2 11.8 5.9 5.9 48.73 3.3796E-67 6575700 2937400 3638400 3006 IPI:IPI00386141.1;IPI:IPI00376960.5;IPI:IPI00376963.1;IPI:IPI00376962.1;IPI:IPI00168431.1 Probable RNA-binding protein 23;RNA-binding motif protein 23;RNA-binding region-containing protein 4;Splicing factor SF2 RBM23;RNPC4;PP239 Q86U06-1;Q86U06;Q86U06-2;Q86U06-5;Q86U06-4;Q86U06-3 ENST00000307814;ENST00000338980;ENST00000346528;ENST00000359890;ENST00000399922 5 0.95547 1.6797 0.75089 1.2099 1.1738 0.92779 cell part;cytoplasmic part;cytosol;intracellular part antioxidant activity;ATP binding;binding;catalytic activity;magnesium ion binding;nucleoside binding;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on sulfur group of donors;purine nucleoside binding;purine nucleotide binding metabolic process;oxidation reduction;response to chemical stimulus;response to oxidative stress;response to stimulus;response to stress 3 3 3 29.2 29.2 29.2 14.259 2.1604E-08 52456000 29601000 22855000 3007 IPI:IPI00168554.1 Sulfiredoxin-1 SRXN1;C20orf139;SRX Q9BYN0 ENST00000381962 K12260 1 NaN 3.8121 1.32 NaN 1.9451 2.1246 DUF1916;GTP_EFTU;GTP_EFTU_D2;GTP_EFTU_D3 binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;nucleic acid binding;nucleotide binding;pyrophosphatase activity;translation elongation factor activity;translation factor activity, nucleic acid binding biosynthetic process;cell communication;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;signal transduction;translation 3 1 1 5.2 2.2 2.2 70.127 1.6348E-08 77828000 34160000 43668000 3008 IPI:IPI00168609.1 HBS1-like protein;ERFS HBS1L;HBS1;KIAA1038 Q9Y450-2;Q9Y450 ENST00000367822;ENST00000367837 1 1.1073 2.4747 1.1633 1.5152 1.4737 1.4835 4 4 4 9.1 9.1 9.1 75.66 8.849E-58 11073000 5755900 5316700 3009 IPI:IPI00168691.7 SHC SH2 domain-binding protein 1 SHCBP1 Q8NEM2 ENST00000303383 1 0.60234 1.8306 NaN 0.85155 1.0818 NaN LAP1C cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part binding;protein binding 2 2 2 7.7 7.7 7.7 51.263 9.8735E-11 1793500 935140 858370 3011 IPI:IPI00168878.1 Torsin-1A-interacting protein 2;Lumenal domain-like LAP1 TOR1AIP2;LULL1 Q8NFQ8 ENST00000367612 1 0.87513 1.6455 0.97122 1.1637 1.0815 1.3431 Renin_r cell part;external side of plasma membrane;integral to membrane;intrinsic to membrane;membrane part;plasma membrane part binding;molecular transducer activity;protein binding;receptor activity;signal transducer activity angiotensin maturation;metabolic process;positive regulation of cytokine production;regulation of cell communication;regulation of cytokine production;regulation of hormone levels;regulation of protein kinase cascade;regulation of signal transduction 4 4 4 14.3 14.3 14.3 39.008 1.2666E-81 33126000 17580000 15547000 3012 IPI:IPI00168884.3 Renin receptor;Renin/prorenin receptor;ATPase H(+)-transporting lysosomal accessory protein 2;ATPase H(+)-transporting lysosomal-interacting protein 2;Vacuolar ATP synthase membrane sector-associated protein M8-9;ATP6M8-9;N14F;ER-localized type I transmembrane adaptor;Embryonic liver differentiation factor 10 ATP6AP2;ATP6IP2;CAPER;ELDF10;HT028;MSTP009;PSEC0072 O75787 ENST00000378438 1 0.74723 1.7066 0.79938 0.97582 1.0973 1.1549 CRAL_TRIO;Motile_Sperm cell part;cytoplasmic part;endoplasmic reticulum;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane;membrane part;membrane-bounded organelle;organelle;plasma membrane structural molecule activity 4 4 4 8.5 8.5 8.5 59.745 7.995E-23 15916000 8387700 7528500 3016 IPI:IPI00169283.1;IPI:IPI00604606.1 Motile sperm domain-containing protein 2 MOSPD2 Q8NHP6-1;Q8NHP6;Q8NHP6-2 ENST00000380492 2 0.76373 1.6374 0.74338 1.0374 1.1106 0.96264 Phospholip_B cell part;cytoplasmic part;intracellular organelle lumen;intracellular organelle part;intracellular part;lysosomal lumen;membrane-enclosed lumen;organelle lumen;organelle part;vacuolar lumen;vacuolar part catalytic activity;hydrolase activity catabolic process;lipid catabolic process;lipid metabolic process;metabolic process;primary metabolic process 6 6 6 12.2 12.2 12.2 65.471 2.3615E-106 120210000 67508000 52701000 3017 IPI:IPI00169285.6 Putative phospholipase B-like 2;Phospholipase B domain-containing protein 2;Lamina ancestor homolog 2;LAMA-like protein 2;76 kDa protein;p76;Putative phospholipase B-like 2 32 kDa form;Putative phospholipase B-like 2 45 kDa form PLBD2 Q8NHP8 ENST00000280800 1 0.51802 1.0067 0.51028 0.66394 0.63936 0.66812 Utp21;WD40 cell part;intracellular part;macromolecular complex;preribosome;ribonucleoprotein complex;small-subunit processome cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA processing;sensory perception;system process;visual perception 22 22 22 34.6 34.6 34.6 105.32 0 411560000 246950000 164600000 3018 IPI:IPI00169325.1 WD repeat-containing protein 36;T-cell activation WD repeat-containing protein WDR36 Q8NI36 ENST00000323652 1 NaN 1.2403 NaN NaN 0.83969 NaN WD40 cell cycle phase;cell cycle process;cell division;cellular component organization;cellular process;mitosis;nuclear division;organelle fission;organelle organization 3 3 3 6.2 6.2 6.2 71.965 5.1711E-08 1213900 611180 602710 3019 IPI:IPI00169345.3 Protein NEDD1;Neural precursor cell expressed developmentally down-regulated protein 1 NEDD1 Q8NHV4 ENST00000266742 1 0.8677 1.7478 0.86384 1.1704 1.1097 1.1591 PGK cell part;cytoplasm;intracellular part ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;phosphoglycerate kinase activity;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups alcohol metabolic process;carbohydrate metabolic process;generation of precursor metabolites and energy;glucose catabolic process;glucose metabolic process;glycolysis;monosaccharide metabolic process;phosphorus metabolic process Carbon fixation in photosynthetic organisms;Glycolysis / Gluconeogenesis 41 41 41 88.7 88.7 88.7 44.614 0 33940000000 17279000000 16660000000 3020 IPI:IPI00169383.3;IPI:IPI00219568.4 Phosphoglycerate kinase 1;Primer recognition protein 2;Cell migration-inducing gene 10 protein PGK1;PGKA;MIG10;OK/SW-cl.110 P00558 ENST00000373316 K00927 2 0.70542 1.5347 0.70847 0.93575 1.0689 0.96866 Ribosomal_S5;Ribosomal_S5_C intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;mitochondrion;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome binding;nucleic acid binding;protein binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 7 7 7 20.9 20.9 20.9 48.006 2.608E-56 83790000 44682000 39108000 3021 IPI:IPI00169400.1;IPI:IPI00215872.3 28S ribosomal protein S5, mitochondrial;S5mt;MRP-S5 MRPS5 P82675-1;P82675 ENST00000272418;ENST00000345084 2 0.72876 1.4972 0.69117 1.0077 0.96382 0.98971 intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;mitochondrion;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome binding;protein binding 9 9 9 44 44 44 25.65 2.9813E-33 278330000 147520000 130810000 3022 IPI:IPI00169413.1 28S ribosomal protein S34, mitochondrial;MRP-S34 MRPS34 P82930 ENST00000177742;ENST00000397375 1 0.74129 1.4356 0.82381 0.93583 0.9081 1.0022 dsrm;DZF cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding developmental process;multicellular organismal development;multicellular organismal process 17 13 13 30.1 24.6 24.6 73.652 2.6682E-260 376060000 195880000 180180000 3024 IPI:IPI00169430.2;IPI:IPI00413860.4 Spermatid perinuclear RNA-binding protein STRBP;SPNR Q96SI9-1;Q96SI9;Q96SI9-2 ENST00000348403;ENST00000373638 2 0.78656 1.4615 0.78138 1.0567 0.91492 0.99298 FPL 4 4 4 4.2 4.2 4.2 117.71 2.3414E-18 119300000 62481000 56823000 3025 IPI:IPI00169441.4;IPI:IPI00917061.1 Protein CLEC16A CLEC16A;KIAA0350 Q2KHT3-1;Q2KHT3;Q2KHT3-2 ENST00000261657;ENST00000381822;ENST00000409790 2 0.39799 0.7695 0.36521 0.50238 0.49865 0.48434 2OG-FeII_Oxy;Ofd1_CTDD cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;iron ion binding;oxidoreductase activity;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen metabolic process;oxidation reduction 5 5 5 11.6 11.6 11.6 63.245 9.5236E-16 79663000 46548000 33115000 3026 IPI:IPI00170429.3;IPI:IPI00402205.4 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1;Termination and polyadenylation 1 homolog OGFOD1;KIAA1612;TPA1 Q8N543-1;Q8N543;Q8N543-2 ENST00000336111 2 0.4226 0.96261 0.4763 0.572 0.61592 0.61888 Pkinase cell part;cytoplasm;intracellular part binding;calcium ion binding;calmodulin-dependent protein kinase activity;catalytic activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;protein tyrosine kinase activity;purine nucleoside binding cell communication;intracellular signaling cascade;MAPKKK cascade;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein kinase cascade;protein modification process;signal transduction Adipocytokine signaling pathway 3 3 3 5.6 5.6 5.6 64.731 4.8223E-09 24434000 14223000 10211000 3027 IPI:IPI00290239.2;IPI:IPI00479420.3;IPI:IPI00292156.1;IPI:IPI00170509.5;IPI:IPI00172500.3;IPI:IPI00172426.2;IPI:IPI00172501.2 Calcium/calmodulin-dependent protein kinase kinase 2;Calcium/calmodulin-dependent protein kinase kinase beta CAMKK2;CAMKKB;KIAA0787 Q96RR4-1;Q96RR4;Q96RR4-7;Q96RR4-4;Q96RR4-3;Q96RR4-2;Q96RR4-5;Q96RR4-6 ENST00000324774;ENST00000337174;ENST00000347034;ENST00000360452;ENST00000392473;ENST00000392474;ENST00000402834;ENST00000404169 K07359 7 0.27111 0.57381 0.25934 0.36645 0.36227 0.37877 AAA;Bromodomain;YL1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;DNA binding;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity;transcription factor activity biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 18 18 17 17.6 17.6 16.8 158.55 6.8968E-89 80698000 44517000 36182000 3028 IPI:IPI00170548.1;IPI:IPI00470801.1 ATPase family AAA domain-containing protein 2;AAA nuclear coregulator cancer-associated protein ATAD2;L16;PRO2000 Q6PL18-1;Q6PL18 ENST00000287394 2 0.65265 1.302 0.62266 0.915 0.82431 0.8489 HDAC_interact;PAH cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part biosynthetic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription Huntington's disease 20 20 20 18.7 18.7 18.7 145.17 5.1991E-261 248850000 120720000 128130000 3029 IPI:IPI00170596.1 Paired amphipathic helix protein Sin3a;Transcriptional corepressor Sin3a;Histone deacetylase complex subunit Sin3a SIN3A Q96ST3 ENST00000360439;ENST00000394947;ENST00000394949 K11644 1 0.81157 1.8405 0.8607 1.1423 1.1212 1.1694 Motile_Sperm cell part;endomembrane system;integral to membrane;intrinsic to membrane;membrane;membrane part;organelle;plasma membrane;vesicle binding;molecular transducer activity;protein binding;protein dimerization activity;protein heterodimerization activity;signal transducer activity;structural molecule activity cellular process;membrane fusion;positive regulation of cell communication;positive regulation of signal transduction;regulation of cell communication;regulation of protein kinase cascade;regulation of signal transduction Tight junction 9 9 8 41.4 41.4 41.4 27.893 7.9304E-82 1237400000 655540000 581890000 3030 IPI:IPI00170692.4 Vesicle-associated membrane protein-associated protein A;33 kDa Vamp-associated protein;VAP-33 VAPA;VAP33 Q9P0L0 ENST00000340541;ENST00000400000 K06096 1 0.5345 0.96989 0.53029 0.73183 0.60624 0.74407 acrosomal vesicle;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;membrane-bounded vesicle;nucleus;organelle;secretory granule;vesicle binding;protein binding acrosome assembly;anatomical structure formation;anatomical structure formation involved in morphogenesis;cellular component assembly;cellular component assembly involved in morphogenesis;cellular component organization;developmental process 8 8 8 4.5 4.5 4.5 265.39 3.8567E-22 20009000 11086000 8923000 3031 IPI:IPI00220694.3;IPI:IPI00170766.4;IPI:IPI00747876.2;IPI:IPI00163659.6 Protein CASC5;Cancer susceptibility candidate gene 5 protein;ALL1-fused gene from chromosome 15q14;Protein D40/AF15q14;Cancer/testis antigen 29 CASC5;KIAA1570 Q8NG31-1;Q8NG31;Q8NG31-2;Q8NG31-4;Q8NG31-3 ENST00000260369;ENST00000346991;ENST00000399668 K11542 4 0.69695 1.3384 0.88569 0.90572 0.88704 1.0822 WW 6 6 6 7.2 7.2 7.2 110.25 3.7107E-70 19815000 10451000 9364200 3032 IPI:IPI00170778.4 Formin-binding protein 4;Formin-binding protein 30 FNBP4;FBP30;KIAA1014 Q8N3X1 ENST00000263773 1 0.85888 1.5644 0.85301 1.1599 0.9893 1.1276 Wbp11 cell part;cytoplasm;intracellular part binding;DNA binding;nucleic acid binding;protein binding;single-stranded DNA binding;structure-specific DNA binding cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing;rRNA processing 10 10 10 13.7 13.7 13.7 69.997 2.3211E-114 218890000 111640000 107250000 3033 IPI:IPI00170786.1 WW domain-binding protein 11;SH3 domain-binding protein SNP70;Npw38-binding protein WBP11;NPWBP;SNP70 Q9Y2W2 ENST00000261167 1 0.86835 1.4214 0.86008 1.0152 1.0409 1.1238 Metallophos cell part;cytoplasmic part;endosomal part;endosome membrane;intracellular organelle part;intracellular part;membrane;organelle membrane;organelle part binding;catalytic activity;cation binding;hydrolase activity;hydrolase activity, acting on ester bonds;ion binding;metal ion binding;phosphatase activity;phosphoric ester hydrolase activity;phosphoserine phosphatase activity;zinc ion binding establishment of localization;establishment of protein localization;protein transport;transport 5 5 5 30.6 30.6 30.6 20.927 5.9242E-24 324430000 172180000 152250000 3034 IPI:IPI00184284.6;IPI:IPI00170796.1 Vacuolar protein sorting-associated protein 29;Vesicle protein sorting 29;PEP11 VPS29;DC7;DC15;MDS007 Q9UBQ0-2;Q9UBQ0;Q9UBQ0-1 ENST00000360579;ENST00000397678 K07095 2 0.35378 0.71546 0.37312 0.46251 0.46522 0.48429 ig;I-set;Pkinase_Tyr;V-set cell part;cytoplasm;integral to membrane;integral to plasma membrane;intracellular part;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part catalytic activity;nucleoside binding;nucleotide binding;protein kinase activity;protein tyrosine kinase activity;purine nucleoside binding;receptor activity;signal transducer activity;transmembrane receptor protein tyrosine kinase activity cell adhesion;cell communication;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process;signal transduction 8 8 8 9.1 9.1 9.1 118.39 6.4131E-60 52021000 29892000 22129000 3035 IPI:IPI00298292.4;IPI:IPI00170814.1;IPI:IPI00478565.2;IPI:IPI00168813.1;IPI:IPI00174794.1 Tyrosine-protein kinase-like 7;Colon carcinoma kinase 4 PTK7;CCK4 Q13308-1;Q13308;Q13308-2;Q13308-4;Q13308-3;Q13308-5 ENST00000230419 K05127 5 0.70904 1.3219 NaN 0.97437 0.83119 NaN Daxx cell part;cytoplasm;intracellular organelle part;intracellular part;nuclear body;nuclear part;nucleoplasm part;organelle part;PML body binding;heat shock protein binding;identical protein binding;nuclear hormone receptor binding;protein binding;protein N-terminus binding;receptor binding;receptor signaling protein activity;signal transducer activity;steroid hormone receptor binding activation of MAPK activity;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein modification process;regulation of protein amino acid phosphorylation;regulation of transcription, DNA-dependent;transcription Amyotrophic lateral sclerosis (ALS);MAPK signaling pathway 2 2 2 4.5 4.5 4.5 81.372 1.4705E-33 44685000 21044000 23641000 3037 IPI:IPI00170867.3;IPI:IPI00220885.1 Death domain-associated protein 6;Daxx;hDaxx;Fas death domain-associated protein;ETS1-associated protein 1 DAXX;BING2;DAP6 Q9UER7-1;Q9UER7;Q9UER7-2 ENST00000266000;ENST00000374542;ENST00000383062;ENST00000383194;ENST00000399060;ENST00000399344 K02308 2 0.83304 1.9779 0.7292 1.1488 1.3315 0.94326 HIT cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle catalytic activity;hydrolase activity 3 3 3 22 22 22 20.361 5.168E-08 41883000 21792000 20091000 3039 IPI:IPI00170924.2 Histidine triad nucleotide-binding protein 3 HINT3 Q9NQE9 ENST00000229633 1 0.60343 1.2447 0.51404 0.7581 0.84683 0.64507 LRR_1 cell part;cytoplasm;intracellular part binding;protein binding 8 8 8 7.2 7.2 7.2 121.46 7.1934E-22 27671000 16084000 11587000 3040 IPI:IPI00170934.3;IPI:IPI00885068.1 Serine/threonine kinase 11-interacting protein;LKB1-interacting protein 1 STK11IP;KIAA1898;LIP1;LKB1IP;STK11IP1 Q8N1F8-1;Q8N1F8 ENST00000295641 2 0.40072 0.87921 0.41071 0.51685 0.58534 0.51108 B3_4;LRR_1 aminoacyl-tRNA ligase activity;binding;catalytic activity;ligase activity;ligase activity, forming carbon-oxygen bonds;nucleic acid binding;phenylalanine-tRNA ligase activity;protein binding;RNA binding biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 17 17 17 32.1 32.1 32.1 63.472 5.8449E-188 1335700000 769220000 566460000 3041 IPI:IPI00170935.1 Leucine-rich repeat-containing protein 47 LRRC47;KIAA1185 Q8N1G4 ENST00000378251 1 0.57204 1.3491 NaN 0.75835 0.91166 NaN DUF2419 2 2 2 5.3 5.3 5.3 39.028 9.1891E-07 7142600 4190900 2951700 3042 IPI:IPI00170972.2 UPF0553 protein C9orf64 C9orf64 Q5T6V5 ENST00000376344 1 0.28726 0.55066 NaN 0.38382 0.38604 NaN AAA_4 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding 7 7 6 8.2 8.2 6.9 102.84 1.8328E-84 21957000 13423000 8534400 3043 IPI:IPI00171044.8;IPI:IPI00470806.4;IPI:IPI00477650.3 Schlafen family member 11 SLFN11 Q7Z7L1 ENST00000308377;ENST00000394566 3 0.56087 1.8652 0.76057 0.82261 1.1849 1.0887 HCaRG cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;identical protein binding;protein binding 4 4 4 35.8 35.8 35.8 21.178 2.3745E-19 28713000 15440000 13272000 3044 IPI:IPI00171117.5 COMM domain-containing protein 1;Protein Murr1 COMMD1;C2orf5;MURR1 Q8N668 ENST00000311832 1 0.68352 NaN NaN 0.93381 NaN NaN zf-C2H2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 2 2 2 6.3 6.3 6.3 67.903 0.0047749 1627300 883360 743930 3045 IPI:IPI00171118.3 Zinc finger protein 668 ZNF668 Q96K58 ENST00000300849;ENST00000394983 1 0.63148 1.3104 0.71647 0.89092 0.81469 0.88964 UBA 9 9 9 12.3 12.3 12.3 117.11 3.0125E-290 70398000 36690000 33708000 3046 IPI:IPI00171127.1 Ubiquitin-associated protein 2 UBAP2;KIAA1491 Q5T6F2 ENST00000360802;ENST00000379238 1 NaN 1.3741 NaN NaN 0.93481 NaN Fumble cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;pantothenate kinase activity;protein binding;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups biosynthetic process;coenzyme metabolic process;group transfer coenzyme metabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process Pantothenate and CoA biosynthesis 2 2 2 6.1 6.1 6.1 62.68 8.2293E-49 1214100 665670 548480 3048 IPI:IPI00171176.3;IPI:IPI00954590.1;IPI:IPI00556350.2;IPI:IPI00550398.1 Pantothenate kinase 2, mitochondrial;Pantothenic acid kinase 2 PANK2;C20orf48 Q9BZ23-1;Q9BZ23;Q9BZ23-4;Q9BZ23-3;Q9BZ23-2 ENST00000316562;ENST00000336066;ENST00000361370;ENST00000399552 K09680 4 0.81054 1.7089 0.86064 1.1073 1.108 1.1184 Proteasome;Proteasome_A_N cytoskeleton;cytosol;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle;proteasome core complex binding;catalytic activity;endopeptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides;protein binding;threonine-type endopeptidase activity;threonine-type peptidase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Proteasome 13 13 13 43.9 43.9 43.9 28.433 1.7294E-171 3996900000 2076800000 1920100000 3049 IPI:IPI00419249.5;IPI:IPI00171199.5 Proteasome subunit alpha type-3;Proteasome component C8;Macropain subunit C8;Multicatalytic endopeptidase complex subunit C8 PSMA3;PSC8 P25788-1;P25788;P25788-2 ENST00000216455 K02727 2 0.6942 1.4248 0.70005 0.89955 0.94164 0.91933 WD40 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;identical protein binding;protein binding;transcription regulator activity;transcription repressor activity biosynthetic process;chromatin organization;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;regulation of transcription, DNA-dependent;transcription 10 10 10 23.8 23.8 23.8 53.06 4.0618E-51 305290000 165130000 140170000 3051 IPI:IPI00432040.1;IPI:IPI00395515.1;IPI:IPI00171248.1 Polycomb protein EED;WD protein associating with integrin cytoplasmic tails 1 EED O75530-2;O75530;O75530-1;O75530-3 ENST00000263360;ENST00000327320;ENST00000351625 K11462 3 0.83082 2.3147 NaN 1.0775 1.6416 NaN FYVE;Myotub-related cell fraction;cell part;cytoplasm;insoluble fraction;intracellular part;membrane;membrane fraction binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;phosphatase activity;phosphoprotein phosphatase activity;protein serine/threonine phosphatase activity;protein tyrosine phosphatase activity;zinc ion binding cellular biopolymer metabolic process;cellular process;dephosphorylation;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid dephosphorylation;protein metabolic process;protein modification process 3 3 3 3 3 3 133.62 9.288E-05 3696300 2232200 1464100 3052 IPI:IPI00185018.7;IPI:IPI00171273.3;IPI:IPI00171274.1 Myotubularin-related protein 3;FYVE domain-containing dual specificity protein phosphatase 1;Zinc finger FYVE domain-containing protein 10 MTMR3;KIAA0371;ZFYVE10 Q13615-1;Q13615;Q13615-2;Q13615-3 ENST00000333027;ENST00000401950 K01104 3 0.79395 1.3692 0.7199 1.0005 0.96028 0.90418 RIO1 ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity 5 5 5 8.8 8.8 8.8 65.582 1.9615E-46 72186000 35433000 36753000 3053 IPI:IPI00171336.3 Serine/threonine-protein kinase RIO1 RIOK1 Q9BRS2 ENST00000264874 K07178 1 0.84102 1.7528 0.83609 1.0301 1.2554 0.98941 PRP38 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 6 6 6 21.2 21.2 21.2 37.476 5.282E-18 247220000 131480000 115740000 3054 IPI:IPI00171390.2 Pre-mRNA-splicing factor 38A PRPF38A Q8NAV1-1;Q8NAV1 ENST00000257181;ENST00000362083 1 NaN 0.94977 NaN NaN 0.62713 NaN LLGL;WD40 cell junction;clathrin-coated vesicle;coated vesicle;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle membrane;integral to membrane;intrinsic to membrane;membrane;organelle membrane;secretory granule;synaptic vesicle;vesicle membrane cellular process;establishment of localization;establishment of localization in cell;establishment of protein localization;exocytosis;protein transport;secretion;secretion by cell;transport;vesicle-mediated transport 2 2 2 2.7 2.7 2.7 127.57 2.8985E-05 611110 286060 325060 3055 IPI:IPI00171407.4;IPI:IPI00645854.1;IPI:IPI00640500.1 Syntaxin-binding protein 5;Tomosyn-1;Lethal(2) giant larvae protein homolog 3 STXBP5;LLGL3 Q5T5C0-1;Q5T5C0;Q5T5C0-2;Q5T5C0-3 ENST00000321680;ENST00000367480;ENST00000367481;ENST00000392291 K08518 3 0.63807 1.3364 0.73245 0.85434 0.87437 0.93158 extracellular region 5 5 5 34.1 34.1 34.1 23.865 5.4576E-36 88682000 48217000 40465000 3056 IPI:IPI00171421.3 UPF0670 protein C8orf55;Mesenchymal stem cell protein DSCD75 C8orf55;PSEC0098 Q8WUY1 ENST00000336138 1 0.79732 1.4404 0.77389 1.0623 0.95916 0.99427 Thioredoxin endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;membrane-enclosed lumen;organelle;organelle lumen;organelle part catalytic activity;isomerase activity anti-apoptosis;cellular homeostasis;cellular process;homeostatic process;negative regulation of apoptosis;negative regulation of programmed cell death;regulation of apoptosis;regulation of cell death;regulation of programmed cell death 13 13 13 35.4 35.4 35.4 47.628 4.9042E-227 1828900000 959770000 869110000 3057 IPI:IPI00171438.2 Thioredoxin domain-containing protein 5;Thioredoxin-like protein p46;Endoplasmic reticulum protein ERp46 TXNDC5;TLP46;UNQ364/PRO700 Q8NBS9 ENST00000379757 1 0.47925 1.0527 NaN 0.60261 0.61656 NaN WD40 2 2 1 4.2 4.2 2 45.008 0.0011587 4104100 2611100 1493000 3058 IPI:IPI00171440.2;IPI:IPI00719213.1 WD repeat-containing protein 51A WDR51A Q8NBT0-1;Q8NBT0;Q8NBT0-2 ENST00000296484;ENST00000394970 2 0.60633 1.3002 0.62025 0.8274 0.83372 0.83022 AAA ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity 8 8 8 24.9 24.9 24.9 40.744 3.3373E-22 102830000 53797000 49034000 3059 IPI:IPI00171445.1;IPI:IPI00929553.1 ATPase family AAA domain-containing protein 1 ATAD1;FNP001 Q8NBU5-1;Q8NBU5;Q8NBU5-2 ENST00000308448;ENST00000328142 2 0.6381 1.3373 0.68496 0.81404 0.91619 0.86339 adh_short binding;catalytic activity;oxidoreductase activity;protein binding metabolic process 8 8 8 23.6 23.6 23.6 37.017 3.5411E-52 156140000 84422000 71718000 3060 IPI:IPI00171459.3 Hydroxysteroid dehydrogenase-like protein 1 HSDL1 Q3SXM5 ENST00000219439 1 0.63256 NaN NaN 0.81055 NaN NaN cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 2 2 2 8.1 8.1 8.1 45.816 5.651E-43 8179000 4570000 3609000 3061 IPI:IPI00171475.2;IPI:IPI00830023.1;IPI:IPI00830040.1 NFATC2-interacting protein;Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein;45 kDa NF-AT-interacting protein;45 kDa NFAT-interacting protein NFATC2IP;NIP45 Q8NCF5-1;Q8NCF5;Q8NCF5-2;Q8NCF5-3 ENST00000320805 3 3.0683 1.4807 0.84306 4.1759 0.90242 1.0811 AAA_5;DHC_N1;DHC_N2;Dynein_heavy axoneme;cilium axoneme;cilium part;cytoplasm;cytoskeletal part;dynein complex;intracellular organelle part;intracellular part;macromolecular complex;membrane;microtubule;microtubule associated complex;organelle part;plasma membrane;protein complex ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;microtubule motor activity;motor activity;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity cellular process;microtubule-based movement;microtubule-based process 3 3 3 0.9 0.9 0.9 493.39 0.0003589 15922000 8430100 7491700 3062 IPI:IPI00171494.6;IPI:IPI00788188.2;IPI:IPI00885216.1 Cytoplasmic dynein 2 heavy chain 1;Cytoplasmic dynein 2 heavy chain;Dynein cytoplasmic heavy chain 2;Dynein heavy chain isotype 1B;Dynein heavy chain 11 DYNC2H1;DHC1B;DHC2;DNCH2;DYH1B;KIAA1997 Q8NCM8-2;Q8NCM8;Q8NCM8-1 ENST00000334267;ENST00000375735;ENST00000398093 3 NaN 0.70708 0.33569 NaN 0.46711 0.43356 Peptidase_C48 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 3 3 3 6.1 6.1 6.1 65.009 7.4011E-35 13597000 8215400 5381200 3063 IPI:IPI00171525.2 Sentrin-specific protease 3;Sentrin/SUMO-specific protease SENP3;SUMO-1-specific protease 3 SENP3;SSP3;SUSP3 Q9H4L4 ENST00000321337 K08593 1 0.87765 1.0153 NaN 1.0783 0.72911 NaN cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 6 6 6 15.1 15.1 15.1 51.391 1.1953E-14 49304000 24859000 24445000 3065 IPI:IPI00171540.2 Protein DERPC;Decreased expression in renal and prostate cancer protein DERPC Q8NDH8 ENST00000306585 1 0.86705 2.5074 0.9342 1.1649 1.555 1.2704 DUF607 cell part;integral to membrane;intrinsic to membrane;membrane part 5 5 5 16.5 16.5 16.5 39.866 1.8099E-14 65727000 33678000 32048000 3066 IPI:IPI00171573.2;IPI:IPI00185975.3 Coiled-coil domain-containing protein 109A CCDC109A;C10orf42 Q8NE86-1;Q8NE86;Q8NE86-2 ENST00000357157;ENST00000373053 2 0.67763 1.4093 0.74315 0.88256 0.94255 0.95364 Histone cell part;chromosomal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;macromolecular complex;membrane-bounded organelle;nucleosome;nucleus;organelle;organelle part;protein-DNA complex binding;DNA binding;nucleic acid binding;protein binding anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;chromatin organization;nucleosome assembly;organelle organization Systemic lupus erythematosus 7 7 1 45.6 45.6 23.5 15.388 3.7899E-160 16631000000 8516800000 8113800000 3067 IPI:IPI00171611.7;IPI:IPI00216402.3;IPI:IPI00419884.3 Histone H3.2;H3/m;H3/o;Histone H3.1t;H3/g HIST2H3A;HIST2H3C;H3F2;H3FM;HIST2H3D;HIST3H3;H3FT Q71DI3;Q16695 ENST00000331491;ENST00000369158;ENST00000401004;ENST00000403683;ENST00000366696 K11253 3 0.72981 1.2882 0.84349 0.94227 0.86915 1.0508 Acyltransferase cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;Golgi apparatus part;Golgi membrane;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part acetyltransferase activity;acyltransferase activity;binding;calcium ion binding;catalytic activity;O-acetyltransferase activity;O-acyltransferase activity;transferase activity;transferase activity, transferring acyl groups biosynthetic process;cellular metabolic process;cellular process;lipid biosynthetic process;lipid metabolic process;metabolic process;organophosphate metabolic process;phospholipid biosynthetic process;phospholipid metabolic process 5 5 5 10.3 10.3 10.3 59.151 1.6426E-167 72827000 39250000 33577000 3069 IPI:IPI00171626.3 Lysophosphatidylcholine acyltransferase 1;1-alkylglycerophosphocholine O-acetyltransferase;Acetyl-CoA:lyso-platelet-activating factor acetyltransferase;1-acylglycerophosphocholine O-acyltransferase;Acyltransferase-like 2;Phosphonoformate immuno-associated protein 3 LPCAT1;AYTL2;PFAAP3 Q8NF37 ENST00000283415 1 0.31987 0.71051 0.29647 0.42562 0.44981 0.41396 WD40 cell part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;organelle part;pore complex;protein complex cellular process;establishment of protein localization;intracellular protein transport;intracellular transport;mRNA transport;nucleic acid transport;nucleobase, nucleoside, nucleotide and nucleic acid transport;protein transport;RNA transport;transport 8 8 8 28.8 28.8 28.8 36.707 9.1772E-73 272660000 167750000 104910000 3070 IPI:IPI00171665.1 Nucleoporin Nup37 NUP37 Q8NFH4 ENST00000251074 1 0.65118 2.0003 1.088 1.0002 1.2289 1.4836 FUN14 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle 5 5 5 18 18 18 20.675 1.6705E-55 30268000 16504000 13765000 3073 IPI:IPI00171769.1 FUN14 domain-containing protein 2;Hepatitis C virus core-binding protein 6;Cervical cancer proto-oncogene 3 protein FUNDC2;HCBP6;DC44;HCC3;PD03104 Q9BWH2 ENST00000355488;ENST00000369498 1 NaN 3.5637 0.88643 NaN 2.2718 1.1789 Actin cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle binding;protein binding 2 2 2 5.6 5.6 5.6 45.81 6.0119E-14 1737600 944280 793300 3074 IPI:IPI00171779.3 Actin-related protein 6 ACTR6;CDA12 Q9GZN1 ENST00000188312 K11662 1 0.80635 1.3795 0.77175 1.0249 0.96778 0.99131 BAH;ELM2;GATA;Myb_DNA-binding binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;sequence-specific DNA binding;transcription factor activity;transcription regulator activity;transition metal ion binding;zinc ion binding cellular component organization;cellular process;chromatin assembly or disassembly;chromatin organization;chromosome organization;organelle organization 23 23 19 40.1 40.1 34.3 75.022 0 1804600000 962090000 842540000 3075 IPI:IPI00171798.1 Metastasis-associated protein MTA2;Metastasis-associated 1-like 1;p53 target protein in deacetylase complex MTA2;MTA1L1;PID O94776 ENST00000278823 K11660 1 0.77642 1.5924 0.82721 1.0348 1.0543 1.0652 PCI cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex;signalosome binding;protein binding 23 23 23 72.4 72.4 72.4 46.268 0 1429700000 756130000 673600000 3076 IPI:IPI00171844.3 COP9 signalosome complex subunit 4;JAB1-containing signalosome subunit 4 COPS4;CSN4 Q9BT78 ENST00000264389 K12178 1 0.72451 1.6076 0.76369 0.97223 1.1321 0.953 HEAT_PBS binding;catalytic activity;deoxyhypusine monooxygenase activity;iron ion binding;monooxygenase activity;oxidoreductase activity;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;protein binding cellular amino acid and derivative metabolic process;cellular amino acid derivative metabolic process;cellular process;metabolic process;peptidyl-amino acid modification;peptidyl-lysine modification to hypusine;protein modification process 8 8 8 30.1 30.1 30.1 32.904 8.401E-190 208190000 110630000 97560000 3077 IPI:IPI00171856.1 Deoxyhypusine hydroxylase;Deoxyhypusine monooxygenase;Deoxyhypusine dioxygenase;HEAT-like repeat-containing protein 1 DOHH;HLRC1 Q9BU89 ENST00000250937 K06072 1 0.78675 1.532 0.79461 1.0186 1.0255 1.0203 RRM_1 integral to membrane;integral to plasma membrane;intracellular organelle;intrinsic to membrane;intrinsic to plasma membrane;macromolecular complex;non-membrane-bounded organelle;nucleolus;organelle;ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;nucleotide binding;protein binding;protein domain specific binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 35 35 35 58.4 58.4 58.4 77.515 0 10257000000 5319000000 4938200000 3078 IPI:IPI00171903.2;IPI:IPI00383296.5 Heterogeneous nuclear ribonucleoprotein M HNRNPM;HNRPM;NAGR1 P52272-1;P52272;P52272-2 ENST00000325495;ENST00000348943 2 NaN 1.405 0.50781 NaN 0.8585 0.76729 PPR 3 3 3 7.6 7.6 7.6 78.855 5.116E-42 3378300 1828100 1550200 3079 IPI:IPI00171925.5 Pentatricopeptide repeat-containing protein 1 PTCD1;KIAA0632 O75127 ENST00000292478 1 0.69761 1.6328 0.69443 0.98104 0.96828 0.95402 CaMKII_AD;Pkinase calcium- and calmodulin-dependent protein kinase complex;cell part;intracellular part;macromolecular complex;protein complex calmodulin-dependent protein kinase activity;catalytic activity;nucleoside binding;nucleotide binding;phosphoprotein phosphatase activity;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding generation of a signal involved in cell-cell signaling;hormone transport;metabolic process;peptide secretion;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;transport 11 11 3 19 19 5.6 65.241 2.4092E-151 220030000 117500000 102530000 3080 IPI:IPI00908444.1;IPI:IPI00334344.2;IPI:IPI00915383.1;IPI:IPI00915327.1;IPI:IPI00915393.1;IPI:IPI00915309.1;IPI:IPI00172450.2;IPI:IPI00296678.4;IPI:IPI00556423.1 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G;CAMKG Q13555-6;Q13555;Q13555-1;Q13555-8;Q13555-2;Q13555-9;Q13555-7;Q13555-4;Q13555-5;Q13555-3 ENST00000305762;ENST00000322635;ENST00000322680;ENST00000394762;ENST00000394763 9 0.95824 1.5836 0.76281 1.2471 1.0832 1.004 zf-C2H2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 4 4 4 12.3 12.3 12.3 63.444 2.3384E-48 35727000 18657000 17070000 3081 IPI:IPI00477661.1;IPI:IPI00172474.3 Zinc finger protein 91 homolog ZFP91;FKSG11 Q96JP5-1;Q96JP5;Q96JP5-2 ENST00000316059;ENST00000389919 2 0.67822 1.2435 0.697 0.86155 0.8759 0.86056 Ribosomal_L17 cell part;cytoplasmic part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome binding;protein binding;protein domain specific binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 6 6 6 27.4 27.4 27.4 20.05 7.2649E-16 169340000 89540000 79805000 3082 IPI:IPI00172591.5 39S ribosomal protein L17, mitochondrial;LYST-interacting protein 2 MRPL17;LIP2 Q9NRX2 ENST00000288937 1 0.66393 2.299 0.7918 0.9098 1.3728 1.0223 intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;mitochondrial ribosome;non-membrane-bounded organelle;organellar ribosome;organelle;organelle part;ribonucleoprotein complex;ribosome binding;DNA binding;nucleic acid binding;structural constituent of ribosome;structural molecule activity;transcription factor activity;transcription regulator activity biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;translation 9 9 9 39.5 39.5 39.5 30.156 1.5762E-84 133660000 73429000 60234000 3083 IPI:IPI00172594.3 39S ribosomal protein L28, mitochondrial;MRP-L28;Melanoma antigen p15;Melanoma-associated antigen recognized by T lymphocytes MRPL28;MAAT1 Q13084 ENST00000199706;ENST00000389675;ENST00000397735 1 1.0098 2.0534 0.84034 1.3478 1.3238 1.1303 CaMKII_AD;Pkinase calcium- and calmodulin-dependent protein kinase complex;cell junction;cell part;intracellular part;macromolecular complex;membrane;membrane part;plasma membrane part;presynaptic membrane;protein complex;synapse part ATP binding;binding;calmodulin binding;calmodulin-dependent protein kinase activity;catalytic activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding biological regulation;regulation of biological process;regulation of biosynthetic process;regulation of cell growth;regulation of cellular process;regulation of gene expression;regulation of growth;regulation of macromolecule biosynthetic process Calcium signaling pathway;ErbB signaling pathway;Glioma;GnRH signaling pathway;Long-term potentiation;Melanogenesis;Olfactory transduction;Wnt signaling pathway 10 5 4 21.4 11.4 9.4 60.032 3.2539E-137 28693000 15783000 12910000 3084 IPI:IPI00654569.2;IPI:IPI00827625.2;IPI:IPI00828178.2;IPI:IPI00827717.2;IPI:IPI00430291.6;IPI:IPI00828139.2;IPI:IPI00827573.2;IPI:IPI00827606.2;IPI:IPI00172636.5;IPI:IPI00215715.4;IPI:IPI00550056.1 Calcium/calmodulin-dependent protein kinase type II delta chain;Calcium/calmodulin-dependent protein kinase type II alpha chain CAMK2D;CAMKD;CAMK2A;CAMKA;KIAA0968 Q13557-4;Q13557;Q13557-11;Q13557-6;Q13557-3;Q13557-1;Q13557-5;Q13557-10;Q13557-9;Q13557-8;Q9UQM7-1;Q9UQM7;Q9UQM7-2 ENST00000296402;ENST00000342666;ENST00000394522;ENST00000394526;ENST00000348628;ENST00000398374;ENST00000398376 K04515 11 0.84053 1.639 0.90568 1.0794 1.0774 1.1243 UBX cell part;cytoplasm;intracellular part binding;protein binding 13 13 13 36.2 36.2 36.2 52.623 1.3981E-289 366520000 178690000 187830000 3085 IPI:IPI00172656.6 FAS-associated factor 2;UBX domain-containing protein 3B;UBX domain-containing protein 8;Protein ETEA FAF2;ETEA;KIAA0887;UBXD8;UBXN3B Q96CS3 ENST00000261942 1 0.68915 1.5196 0.6684 0.90432 0.98905 0.89585 PGM_PMM_I;PGM_PMM_II catalytic activity;intramolecular transferase activity;isomerase activity;kinase activity;phosphotransferase activity, alcohol group as acceptor;transferase activity;transferase activity, transferring phosphorus-containing groups alcohol metabolic process;carbohydrate metabolic process;glucose metabolic process;hexose metabolic process;metabolic process;monosaccharide metabolic process;primary metabolic process Starch and sucrose metabolism 11 11 11 20.1 20.1 20.1 70.455 2.7608E-57 70971000 35422000 35549000 3086 IPI:IPI00173346.3 Glucose 1,6-bisphosphate synthase;Phosphoglucomutase-2-like 1;PMMLP PGM2L1;BM32A Q6PCE3 ENST00000298198 K11809 1 0.5743 0.88634 0.38666 0.7532 0.52186 0.53712 MORN endoplasmic reticulum membrane;integral to membrane;intrinsic to membrane;junctional membrane complex;junctional sarcoplasmic reticulum membrane;macromolecular complex;membrane;organelle membrane;plasma membrane;sarcoplasmic reticulum membrane calcium ion transport;cation transport;cellular calcium ion homeostasis;cellular ion homeostasis;cellular metal ion homeostasis;cellular process;elevation of cytosolic calcium ion concentration;ion transport;transport 4 4 4 7.7 7.7 7.7 71.685 3.26E-29 8936300 4116900 4819500 3088 IPI:IPI00173461.1 Junctophilin-1;Junctophilin type 1 JPH1;JP1 Q9HDC5 ENST00000342232 1 NaN 0.92845 NaN NaN 0.64227 NaN Ank;TPR_1 cell junction;cell part;cytoskeletal part;intracellular organelle part;intracellular part;membrane;membrane part;organelle part;plasma membrane part;postsynaptic density;postsynaptic membrane;synapse part binding 6 6 6 5.1 5.1 5.1 202.19 0.00010542 13371000 8357600 5013300 3089 IPI:IPI00173946.7;IPI:IPI00885010.1 Protein TANC1;Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1 TANC1;KIAA1728 Q9C0D5-1;Q9C0D5;Q9C0D5-2 ENST00000263635 2 0.7928 1.4859 0.74882 0.98966 1.0366 0.96296 Exo_endo_phos catalytic activity;hydrolase activity 12 12 12 23.3 23.3 23.3 67.351 2.6145E-163 386940000 204220000 182710000 3091 IPI:IPI00174390.3;IPI:IPI00886797.1 2',5'-phosphodiesterase 12 PDE12 Q6L8Q7-1;Q6L8Q7;Q6L8Q7-2 ENST00000311180 2 0.6127 1.2794 0.57604 0.76717 0.87767 0.73912 F-box;SPRY catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 3 3 3 10.8 10.8 10.8 30.632 6.534E-15 14298000 7800400 6497200 3092 IPI:IPI00174438.2 F-box/SPRY domain-containing protein 1;F-box only protein 45 FBXO45;FBX45 P0C2W1 ENST00000311630 K10319 1 1.2814 1.5323 0.76061 1.7964 0.92682 1.0803 DUF2465 10 10 9 22.4 22.4 19.7 55.4 1.9983E-243 88393000 47008000 41385000 3093 IPI:IPI00174442.2 Protein FAM98A FAM98A Q8NCA5 ENST00000395190 1 0.85975 1.5723 0.82524 1.1277 1.0541 1.1084 TATA_RF cell part;intracellular organelle part;intracellular part;macromolecular complex;mediator complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;catalytic activity;DNA-directed RNA polymerase activity;general RNA polymerase II transcription factor activity;protein binding;RNA polymerase II transcription factor activity;RNA polymerase II transcription mediator activity;transferase activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 2 2 2 9.4 9.4 9.4 23.222 2.5028E-07 59712000 31748000 27965000 3094 IPI:IPI00174852.4 Mediator of RNA polymerase II transcription subunit 20;Mediator complex subunit 20;TRF-proximal protein homolog MED20;TRFP Q9H944 ENST00000265350 1 0.91024 2.0617 0.85425 1.1804 1.428 1.1742 CH;LIM cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding 4 4 3 5.4 5.4 4.2 93.44 6.5046E-40 11032000 5981000 5051200 3095 IPI:IPI00174962.2;IPI:IPI00410369.2;IPI:IPI00410371.3 MICAL-like protein 1;Molecule interacting with Rab13 MICALL1;KIAA1668;MIRAB13 Q8N3F8 ENST00000215957 3 0.94276 NaN NaN 1.3937 NaN NaN Tmemb_55A cytoplasmic part;endosomal part;endosome membrane;integral to membrane;intracellular part;intrinsic to membrane;late endosome membrane;lysosomal membrane;membrane;membrane part;organelle membrane;organelle part;vacuolar membrane;vacuolar part catalytic activity;hydrolase activity 3 2 2 14.8 10.9 10.9 28.081 2.0245E-19 331590 166340 165240 3097 IPI:IPI00175029.1 Transmembrane protein 55A;Type II phosphatidylinositol 4,5-bisphosphate 4-phosphatase;PtdIns-4,5-P2 4-Ptase II TMEM55A Q8N4L2 ENST00000285419 1 0.83002 2.0312 NaN 1.0831 1.4174 NaN PA;zf-C3HC4 cell part;cytoplasm;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;plasma membrane binding;catalytic activity;cation binding;ion binding;ligase activity;metal ion binding;protein binding;transition metal ion binding;zinc ion binding catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 2 2 2 5.5 5.5 5.5 43.164 9.0587E-07 1263200 696020 567140 3098 IPI:IPI00175092.5 E3 ubiquitin-protein ligase RNF149;RING finger protein 149;DNA polymerase-transactivated protein 2 RNF149;DNAPTP2 Q8NC42 ENST00000295317 1 0.79287 1.5144 0.78494 1.0691 1.077 1.0768 TPR_1;TPR_2 binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 6 6 6 31.6 31.6 31.6 20.012 2.1174E-88 385100000 199130000 185970000 3099 IPI:IPI00175096.1 Tetratricopeptide repeat protein 9C TTC9C Q8N5M4 ENST00000294161;ENST00000316461 1 1.0111 1.1512 0.68948 1.2658 0.83217 0.91019 RRM_1;SPOC cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding mRNA processing;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of alternative nuclear mRNA splicing, via spliceosome;regulation of transcription, DNA-dependent;RNA processing;transcription 2 2 2 3.3 3.3 3.3 97.204 1.4547E-138 54585000 34516000 20069000 3100 IPI:IPI00175136.5 Putative RNA-binding protein 15B;RNA-binding motif protein 15B;One-twenty two protein 3 RBM15B;OTT3 Q8NDT2 ENST00000323686 1 0.59261 0.91012 0.41803 0.79796 0.56868 0.578 zf-C3H1 cell part;cytoskeleton;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding cellular biopolymer metabolic process;cellular process;macromolecule metabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing 7 7 7 4 4 4 226.35 6.4446E-14 9393700 5400900 3992900 3101 IPI:IPI00743894.2;IPI:IPI00175146.5 Zinc finger C3H1 domain-containing protein;Coiled-coil domain-containing protein 131;Proline/serine-rich coiled-coil protein 2 ZFC3H1;CCDC131;KIAA0546;PSRC2 O60293-1;O60293;O60293-2 ENST00000308101;ENST00000378743 2 0.91625 1.7259 1.0355 1.2451 1.1438 1.3208 ArfGap cell part;cytoplasmic part;Golgi apparatus part;Golgi membrane;intracellular organelle part;intracellular part;membrane;organelle membrane;organelle part ARF GTPase activator activity;binding;cation binding;enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;ion binding;metal ion binding;small GTPase regulator activity;zinc ion binding cellular component organization;cellular process;organelle organization;protein transport;regulation of ARF GTPase activity;retrograde vesicle-mediated transport, Golgi to ER;transport;vesicle coating;vesicle organization;vesicle-mediated transport 4 4 4 13 13 13 45.675 9.668E-106 13422000 6574500 6847500 3102 IPI:IPI00217354.3;IPI:IPI00175169.3;IPI:IPI00449160.1 ADP-ribosylation factor GTPase-activating protein 1;ADP-ribosylation factor 1 GTPase-activating protein;ARF1-directed GTPase-activating protein ARFGAP1;ARF1GAP Q8N6T3-2;Q8N6T3;Q8N6T3-1;Q8N6T3-3 ENST00000353546;ENST00000370275;ENST00000370283 3 0.63151 1.6765 NaN 0.91876 1.1248 NaN 3 3 3 7.8 7.8 7.8 63.351 2.9824E-62 2170300 1261900 908380 3103 IPI:IPI00176157.3;IPI:IPI00844438.1;IPI:IPI00645777.2 Uncharacterized protein C5orf37 C5orf37 Q8NA72-1;Q8NA72;Q8NA72-3;Q8NA72-2 ENST00000282199 3 0.4604 1.1973 NaN 0.67516 0.75735 NaN zf-MIZ cell part;chromosomal part;cytoplasm;intracellular organelle part;intracellular part;nuclear body;nuclear chromosome part;nuclear part;nuclear replication fork;nuclear speck;nucleoplasm part;organelle part;replication fork binding;cation binding;ion binding;metal ion binding;protein binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding;transition metal ion binding;zinc ion binding biosynthetic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription 4 4 4 3.8 3.8 3.8 115.48 3.9205E-07 3731100 2030200 1700900 3105 IPI:IPI00176571.4;IPI:IPI00477110.1;IPI:IPI00302607.5;IPI:IPI00289799.3;IPI:IPI00845315.1 Zinc finger MIZ domain-containing protein 1;Retinoic acid-induced protein 17;PIAS-like protein Zimp10;Zinc finger MIZ domain-containing protein 2;PIAS-like protein Zimp7 ZMIZ1;KIAA1224;RAI17;ZIMP10;ZMIZ2;KIAA1886;ZIMP7;HRIHFB2007 Q9ULJ6-1;Q9ULJ6;Q9ULJ6-2;Q8NF64-1;Q8NF64;Q8NF64-2;Q8NF64-3 ENST00000334512;ENST00000360331;ENST00000372347;ENST00000265346;ENST00000309315 5 0.52851 1.2354 0.46954 0.78076 0.79493 0.65561 Pkinase cell part;chromosomal part;chromosome, centromeric region;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;nucleus;organelle;organelle part ATP binding;binding;catalytic activity;kinase activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cellular component organization;cellular process;metabolic process;mitosis;nuclear division;organelle organization;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein modification process 6 5 5 20.3 18 18 39.28 1.4346E-55 48307000 27688000 20620000 3106 IPI:IPI00176642.3 Serine/threonine-protein kinase 12;Aurora-B;Aurora- and Ipl1-like midbody-associated protein 1;Aurora/IPL1-related kinase 2;STK-1 AURKB;AIK2;AIM1;ARK2;STK12 Q96GD4 ENST00000316199 K11479 1 0.75684 1.5805 0.76587 1.0351 1.047 1.0073 G-patch;RRM_1 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;nucleotide binding;RNA binding cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 12 12 12 31.9 31.9 31.9 44.961 1.686E-107 361040000 198890000 162150000 3107 IPI:IPI00176706.1 Splicing factor 45;45 kDa-splicing factor;RNA-binding motif protein 17 RBM17;SPF45 Q96I25 ENST00000379888 1 0.59784 1.3529 0.64539 0.82775 0.91364 0.8465 Hydrolase catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;phosphatase activity;phosphoglycolate phosphatase activity;phosphoric ester hydrolase activity carbohydrate metabolic process;metabolic process;primary metabolic process Glyoxylate and dicarboxylate metabolism 8 8 8 38.3 38.3 38.3 34.006 1.0163E-161 184420000 99023000 85394000 3109 IPI:IPI00177008.1 Phosphoglycolate phosphatase PGP A6NDG6 ENST00000333503 K01091 1 0.86733 1.754 1.0692 1.2732 1.1444 1.4245 MA3;MIF4G cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;protein binding;RNA binding cellular process;metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of gene expression;RNA metabolic process;RNA processing;RNA splicing 15 15 15 17.7 17.7 17.7 105.53 5.9286E-192 295480000 155510000 139970000 3110 IPI:IPI00177381.8 Pre-mRNA-splicing factor CWC22 homolog;Nucampholin homolog;fSAPb CWC22;KIAA1604;NCM Q9HCG8 ENST00000410053 1 0.91353 1.753 0.90649 1.1949 1.1428 1.189 HAT cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;RNA binding anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;ribonucleoprotein complex assembly;spliceosome assembly 19 19 19 21.8 21.8 21.8 100.45 2.7229E-153 392040000 203290000 188750000 3111 IPI:IPI00177437.5;IPI:IPI00219317.3;IPI:IPI00219318.3 Crooked neck-like protein 1;Crooked neck homolog CRNKL1;CRN;CGI-201;MSTP021 Q9BZJ0-1;Q9BZJ0;Q9BZJ0-2;Q9BZJ0-3 ENST00000377327 3 0.75152 1.4375 0.73754 0.93904 0.979 0.91431 TRAPP cell part;cytoplasmic part;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle cellular process;establishment of localization;transport;vesicle-mediated transport 5 5 5 33 33 33 20.783 1.2887E-56 149470000 72698000 76772000 3112 IPI:IPI00177509.4 Trafficking protein particle complex subunit 5 TRAPPC5 Q8IUR0 ENST00000317378 1 0.80696 1.5911 0.85074 1.0193 1.0853 1.0847 3 3 3 7.2 7.2 7.2 59.702 2.3728E-21 26813000 13260000 13553000 3113 IPI:IPI00177642.8 Coiled-coil domain-containing protein 9 CCDC9 Q9Y3X0 ENST00000221922 1 NaN NaN 0.41253 NaN NaN 0.66159 AT_hook cell part;chromatin;chromosomal part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex AT DNA binding;binding;DNA binding;nucleic acid binding;protein binding;receptor binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor activity;transcription factor binding chromatin organization;DNA metabolic process;DNA recombination;DNA unwinding during replication;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleosome disassembly;regulation of chromatin assembly or disassembly 2 1 1 34.4 14.6 14.6 10.679 0.00052028 11109000 6824600 4284400 3114 IPI:IPI00177716.7 High mobility group protein HMG-I/HMG-Y;High mobility group AT-hook protein 1 HMGA1;HMGIY P17096-2;P17096 ENST00000311487;ENST00000357318;ENST00000360434;ENST00000374116;ENST00000374117;ENST00000395004;ENST00000401473 1 0.86384 1.6666 0.87186 1.1277 1.0888 1.1281 M20_dimer;Peptidase_M20 binding;carboxypeptidase activity;catalytic activity;cation binding;exopeptidase activity;hydrolase activity;ion binding;metal ion binding;metallopeptidase activity;peptidase activity;protein binding;transition metal ion binding;zinc ion binding biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis 21 21 21 50.7 50.7 50.7 52.878 0 1325900000 687580000 638360000 3115 IPI:IPI00177728.3;IPI:IPI00165579.6 Cytosolic non-specific dipeptidase;CNDP dipeptidase 2;Glutamate carboxypeptidase-like protein 1;Peptidase A CNDP2;CN2;CPGL;PEPA Q96KP4-1;Q96KP4;Q96KP4-2 ENST00000324262 K08660 2 0.81088 1.6124 0.78011 1.0507 1.1106 0.97957 cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;CARD domain binding;protein binding;protein domain specific binding negative regulation of cell communication;negative regulation of protein kinase cascade;negative regulation of signal transduction;regulation of cell communication;regulation of protein kinase cascade;regulation of signal transduction 2 2 2 8.3 8.3 8.3 25.589 3.8006E-06 11369000 5008600 6360000 3116 IPI:IPI00336153.8;IPI:IPI00177808.9 Bcl10-interacting CARD protein C9orf89 Q96LW7-1;Q96LW7;Q96LW7-2 ENST00000375464 2 1.1453 1.9329 1.1126 1.4496 1.2685 1.3599 TLE_N;WD40 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding cell communication;cell surface receptor linked signal transduction;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;signal transduction;transcription 11 11 1 19.3 19.3 2.3 83.416 4.9609E-84 249400000 124130000 125270000 3117 IPI:IPI00219368.4;IPI:IPI00177938.2;IPI:IPI00297659.3 Transducin-like enhancer protein 3;ESG3 TLE3;KIAA1547 Q04726-1;Q04726;Q04726-2 ENST00000317509 3 NaN 3.2844 0.74224 NaN 2.25 0.88411 adh_short cell part;cytoplasmic part;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle binding;catalytic activity;oxidoreductase activity metabolic process;oxidation reduction 4 4 4 14 14 14 36.864 5.1974E-07 9318000 5448600 3869400 3118 IPI:IPI00177940.2 Retinol dehydrogenase 14;Alcohol dehydrogenase PAN2 RDH14;PAN2;UNQ529/PRO1072 Q9HBH5 ENST00000359846;ENST00000381249 K11162 1 0.7729 1.1994 0.74493 0.96178 0.80995 0.95226 5_nucleotid binding;catalytic activity;cation binding;hydrolase activity;ion binding;magnesium ion binding;metal ion binding 4 4 4 13.2 13.2 13.2 51.844 4.3522E-178 77583000 38478000 39104000 3119 IPI:IPI00177965.5 5'-nucleotidase domain-containing protein 1 NT5DC1;NT5C2L1;LP2642 Q5TFE4 ENST00000319550 1 0.69616 1.4739 0.63295 0.92607 1.002 0.83808 Kinesin cell part;cytoplasm;cytoskeletal part;intracellular organelle part;intracellular part;microtubule;nuclear matrix;nuclear part;organelle part;spindle microtubule ATP binding;binding;catalytic activity;DNA binding;hydrolase activity;microtubule motor activity;motor activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity anterograde axon cargo transport;axon cargo transport;cellular component organization;cellular process;microtubule-based movement;microtubule-based process;microtubule-based transport;organelle organization;transport 19 19 18 15 15 15 139.88 3.5354E-156 162950000 99547000 63401000 3121 IPI:IPI00178150.5;IPI:IPI00556059.1;IPI:IPI00175193.5 Chromosome-associated kinesin KIF4A;Chromosome-associated kinesin KIF4B KIF4A;KIF4;KIF4B O95239-1;O95239;O95239-2;Q2VIQ3 ENST00000374388;ENST00000374403 K10395 3 0.6738 1.3618 0.60296 0.88011 0.93274 0.81087 BicD cell part;cytoplasmic part;cytoskeleton;Golgi apparatus;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;non-membrane-bounded organelle;organelle binding;protein binding 7 7 6 8.9 8.9 8.1 96.805 3.4324E-11 39638000 22016000 17622000 3122 IPI:IPI00337667.1;IPI:IPI00178185.1 Protein bicaudal D homolog 2 BICD2;KIAA0699 Q8TD16-2;Q8TD16;Q8TD16-1 ENST00000356884;ENST00000375512 2 0.70781 NaN NaN 0.95076 NaN NaN CH cell part;cytoplasm;intracellular part;membrane 2 2 2 2.3 2.3 2.3 140.02 2.2537E-14 599410 341170 258250 3123 IPI:IPI00178187.4;IPI:IPI00845271.1;IPI:IPI00433194.2 EH domain-binding protein 1 EHBP1;KIAA0903;NACSIN Q8NDI1-1;Q8NDI1;Q8NDI1-2;Q8NDI1-3 ENST00000263991;ENST00000354487 3 0.58447 1.2023 0.55732 0.74279 0.78389 0.68719 Acid_phosphat_A cell part;cytoplasmic part;cytosol;intracellular part inositol 1,3,4,5,6-pentakisphosphate kinase activity;inositol hexakisphosphate 5-kinase activity;inositol hexakisphosphate kinase activity;inositol pyrophosphate synthase activity;nucleoside binding;nucleotide binding;purine nucleoside binding alcohol metabolic process;inositol metabolic process;metabolic process;polyol metabolic process 8 8 5 8 8 4.5 140.41 4.8542E-47 38401000 20599000 17803000 3124 IPI:IPI00784254.2;IPI:IPI00178375.3 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2;InsP6 and PP-IP5 kinase 2;Histidine acid phosphatase domain-containing protein 1 HISPPD1;KIAA0433;PPIP5K2;VIP2 O43314-1;O43314;O43314-2 ENST00000321521;ENST00000358359 2 0.64934 1.4829 0.63116 0.85356 0.90456 0.86027 DEAD;Helicase_C cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;ATP-dependent DNA helicase activity;binding;catalytic activity;DNA binding;DNA helicase activity;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding cellular process;DNA metabolic process;DNA recombination;DNA repair;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to DNA damage stimulus;response to stress 24 24 24 45.8 45.8 45.8 73.457 0 650740000 350120000 300620000 3125 IPI:IPI00178431.12 ATP-dependent DNA helicase Q1;DNA-dependent ATPase Q1 RECQL;RECQL1 P46063 ENST00000314748 1 0.66542 1.3864 0.66649 0.86453 0.90582 0.88648 EF-1_beta_acid;EF1_GNE cell part;cytoplasmic part;cytosol;eukaryotic translation elongation factor 1 complex;intracellular part;macromolecular complex;protein complex binding;nucleic acid binding;protein binding;translation elongation factor activity;translation factor activity, nucleic acid binding;translation regulator activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation 8 6 6 46.7 41.3 41.3 24.763 0 3309000000 1847600000 1461400000 3126 IPI:IPI00178440.3 Elongation factor 1-beta EEF1B2;EEF1B;EF1B P24534 ENST00000236957;ENST00000392221;ENST00000392222 K03232 1 0.6135 3.3277 NaN 0.81385 2.1894 NaN DnaJ;DUF1977 cell part;integral to membrane;intrinsic to membrane;membrane part binding;heat shock protein binding;protein binding;unfolded protein binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 3 3 3 10.6 10.6 10.6 42.515 6.1374E-49 5289700 3424600 1865000 3127 IPI:IPI00178504.5;IPI:IPI00410274.4 DnaJ homolog subfamily B member 14 DNAJB14;UNQ9427/PRO34683 Q8TBM8-1;Q8TBM8;Q8TBM8-2 ENST00000334223;ENST00000337833 K09520 2 0.96005 1.529 0.88472 1.253 1.0503 1.1445 Acyl-CoA_dh_1;Acyl-CoA_dh_M;Acyl-CoA_dh_N cell part;cytoplasmic part;intracellular organelle part;intracellular part;membrane;mitochondrial inner membrane;mitochondrial membrane;mitochondrial nucleoid;mitochondrial part;nucleoid;organelle inner membrane;organelle membrane;organelle part acyl-CoA dehydrogenase activity;binding;catalytic activity;electron carrier activity;long-chain-acyl-CoA dehydrogenase activity;nucleoside binding;nucleotide binding;oxidoreductase activity;purine nucleoside binding catabolic process;cellular process;fatty acid beta-oxidation;fatty acid catabolic process;fatty acid metabolic process;generation of precursor metabolites and energy;lipid metabolic process;metabolic process;organic acid metabolic process Fatty acid metabolism 21 21 21 33.7 33.7 33.7 72.877 0 701080000 352060000 349030000 3129 IPI:IPI00178744.4;IPI:IPI00937735.1 Very long-chain specific acyl-CoA dehydrogenase, mitochondrial ACADVL;VLCAD P49748-2;P49748;P49748-1 ENST00000322910;ENST00000350303;ENST00000356839 K09479 2 0.84254 1.5125 NaN 1.0523 0.88404 NaN Nefa_Nip30_N cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 4 4 4 18.1 18.1 18.1 28.912 2.8729E-19 42477000 22717000 19760000 3130 IPI:IPI00178750.3 NEFA-interacting nuclear protein NIP30 NIP30;CDA10;CDA018 Q9GZU8 ENST00000309137 1 NaN 1.5796 NaN NaN 0.98008 NaN WD40 binding;protein binding 2 2 2 4.2 4.2 4.2 61.669 0.0042148 1181400 713650 467800 3134 IPI:IPI00178972.5;IPI:IPI00328589.1;IPI:IPI00328631.1 WD repeat-containing protein 23 WDR23;GL014;PRO2389 Q8TEB1-1;Q8TEB1;Q8TEB1-2;Q8TEB1-3 ENST00000326009;ENST00000334688 K11801 3 0.78125 1.5362 NaN 1.0516 1.0182 NaN RRM_1;SET cell part;histone methyltransferase complex;intracellular organelle part;intracellular part;macromolecular complex;methyltransferase complex;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part;protein complex binding;catalytic activity;methyltransferase activity;N-methyltransferase activity;nucleic acid binding;nucleotide binding;protein binding;protein methyltransferase activity;RNA binding;S-adenosylmethionine-dependent methyltransferase activity biosynthetic process;chromatin organization;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;regulation of transcription, DNA-dependent;transcription Lysine degradation 3 3 3 2 2 2 186.03 2.1401E-11 7328900 3961200 3367700 3135 IPI:IPI00179016.8 Histone-lysine N-methyltransferase SETD1A;SET domain-containing protein 1A;Set1/Ash2 histone methyltransferase complex subunit SET1;Lysine N-methyltransferase 2F SETD1A;KIAA0339;KMT2F;SET1;SET1A O15047 ENST00000262519 K11422 1 0.83219 1.6391 0.83954 1.0889 1.1077 1.0677 PUA cell part;cytoplasm;intracellular part binding;nucleic acid binding;RNA binding cell cycle;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;response to DNA damage stimulus;response to stress;transcription 8 8 8 42 42 42 20.555 0 409030000 215150000 193870000 3136 IPI:IPI00179026.2;IPI:IPI00900380.1 Malignant T cell amplified sequence 1;Multiple copies T-cell malignancies MCTS1;MCT1 Q9ULC4-1;Q9ULC4;Q9ULC4-2 ENST00000371315;ENST00000371317;ENST00000394552 2 0.46594 1 0.5374 0.6508 0.62614 0.72797 Cullin;Cullin_Nedd8 cell part;cullin-RING ubiquitin ligase complex;intracellular part;macromolecular complex;protein complex;ubiquitin ligase complex binding;enzyme binding;protein binding;ubiquitin protein ligase binding DNA metabolic process;DNA repair;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;proteolysis;response to DNA damage stimulus;response to stress;ubiquitin-dependent protein catabolic process Nucleotide excision repair;Ubiquitin mediated proteolysis 9 3 2 10.8 3.8 3.2 103.98 2.9985E-64 24604000 14527000 10078000 3137 IPI:IPI00480142.2;IPI:IPI00179057.6;IPI:REV_IPI00922370.3 Cullin-4B CUL4B;KIAA0695 Q13620-2;Q13620;Q13620-1 ENST00000336592;ENST00000371322 K10609 3 0.61269 1.1429 0.78424 0.89805 0.71932 1.0629 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex binding;chromatin binding;estrogen receptor binding;protein binding;receptor binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding DNA metabolic process;DNA recombination;DNA repair;DNA replication;in utero embryonic development;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription initiation 3 3 3 2.3 2.3 2.3 219.14 4.7733E-08 49803000 25620000 24183000 3138 IPI:IPI00179071.2 Nuclear receptor coactivator 6;Amplified in breast cancer protein 3;Cancer-amplified transcriptional coactivator ASC-2;Activating signal cointegrator 2;Peroxisome proliferator-activated receptor-interacting protein;Nuclear receptor-activating protein, 250 kDa;Nuclear receptor coactivator RAP250;Thyroid hormone receptor-binding protein NCOA6;AIB3;KIAA0181;RAP250;TRBP Q14686 ENST00000359003;ENST00000374796 1 1.1503 1.5483 0.83199 1.5467 1.0039 1.1236 SIR2 cell part;chromatin remodeling complex;chromatin silencing complex;cytoplasm;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;microtubule;nuclear part;organelle part;protein complex binding;catalytic activity;histone deacetylase activity;hydrolase activity;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;nucleotide binding;protein binding;transcription factor binding;zinc ion binding chromatin organization;chromatin silencing;chromatin silencing at rDNA;chromatin silencing at telomere;nuclear division;protein amino acid ADP-ribosylation;protein modification process;regulation of transcription, DNA-dependent 4 4 4 11.8 11.8 11.8 43.182 1.2611E-59 20053000 10426000 9627800 3139 IPI:IPI00179109.2;IPI:IPI00472047.1;IPI:IPI00382551.1;IPI:IPI00382553.1 NAD-dependent deacetylase sirtuin-2;SIR2-like protein 2 SIRT2;SIR2L;SIR2L2 Q8IXJ6-1;Q8IXJ6;Q8IXJ6-3;Q8IXJ6-2;Q8IXJ6-4 ENST00000249396;ENST00000358931;ENST00000392081 K11412 4 0.72645 1.8733 0.83237 0.90011 1.3095 1.0582 SAM_1;SAM_2 cell part;cytoplasm;intracellular part;membrane;plasma membrane binding;protein binding biological adhesion;cell adhesion;cellular process 3 3 3 3.9 3.9 3.9 114.02 0.00013364 10047000 5505200 4541400 3140 IPI:IPI00397366.4;IPI:IPI00179172.6;IPI:IPI00397368.2;IPI:IPI00397367.1;IPI:IPI00302158.2 Liprin-beta-1;Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1 PPFIBP1;KIAA1230 Q86W92-1;Q86W92;Q86W92-2;Q86W92-4;Q86W92-3 ENST00000228425;ENST00000318304 5 0.72243 1.3605 0.62872 0.92405 0.93194 0.84869 DnaJ;DnaJ_C;DnaJ_CXXCXGXG cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part binding;cation binding;heat shock protein binding;ion binding;metal ion binding;protein binding;transition metal ion binding;unfolded protein binding;zinc ion binding apoptosis;cell death;cellular biopolymer metabolic process;cellular process;death;metabolic process;negative regulation of cell proliferation;programmed cell death;protein folding;protein metabolic process;regulation of cell proliferation 8 8 8 21.2 21.2 21.2 52.537 1.175E-74 86019000 47096000 38922000 3141 IPI:IPI00294610.3;IPI:IPI00179187.3 DnaJ homolog subfamily A member 3, mitochondrial;Tumorous imaginal discs protein Tid56 homolog;DnaJ protein Tid-1;Hepatocellular carcinoma-associated antigen 57 DNAJA3;HCA57;TID1 Q96EY1-1;Q96EY1;Q96EY1-2 ENST00000262375;ENST00000355296 2 0.85004 1.5029 0.93631 1.1494 0.9982 1.208 Ribosomal_L40e;Ribosomal_S27;ubiquitin cell part;cytoplasmic part;cytosol;cytosolic part;cytosolic small ribosomal subunit;intracellular organelle part;intracellular part;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit;ribosome;small ribosomal subunit binding;cation binding;ion binding;metal ion binding;protein binding;structural constituent of ribosome;structural molecule activity;transcription regulator activity;transition metal ion binding;zinc ion binding biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Parkinson's disease;PPAR signaling pathway 16 16 16 71.8 71.8 71.8 17.965 0 25596000000 12578000000 13018000000 3142 IPI:IPI00179330.6;IPI:IPI00456429.3;IPI:IPI00798155.4 40S ribosomal protein S27a;60S ribosomal protein L40;CEP52;Ubiquitin RPS27A;UBA80;UBCEP1;UBA52;UBCEP2;UBB;UBC P62979;P62987;P62988 ENST00000272317;ENST00000402285;ENST00000404735;ENST00000408928;ENST00000302182;ENST00000325925;ENST00000339545;ENST00000339647;ENST00000376781;ENST00000392398;ENST00000395837;ENST00000395839 K04551;K08770 3 0.75649 1.4128 0.75438 0.9556 1.0099 0.94123 Metallophos calcineurin complex;cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;protein complex;protein serine/threonine phosphatase complex binding;calcium ion binding;calmodulin binding;catalytic activity;hydrolase activity;iron ion binding;phosphoprotein phosphatase activity;protein binding;protein serine/threonine phosphatase activity;zinc ion binding cellular biopolymer metabolic process;cellular process;dephosphorylation;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid dephosphorylation;protein metabolic process;protein modification process Alzheimer's disease;Amyotrophic lateral sclerosis (ALS);Apoptosis;Axon guidance;B cell receptor signaling pathway;Calcium signaling pathway;Long-term potentiation;MAPK signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;VEGF signaling pathway;Wnt signaling pathway 12 12 10 19.4 19.4 15.7 58.687 5.4004E-123 136700000 74530000 62172000 3143 IPI:IPI00179415.4;IPI:IPI00747748.1;IPI:IPI00872930.1;IPI:IPI00181738.3;IPI:IPI00218862.1 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform;Calmodulin-dependent calcineurin A subunit alpha isoform;CAM-PRP catalytic subunit;Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform;Calmodulin-dependent calcineurin A subunit beta isoform PPP3CA;CALNA;CNA;PPP3CB;CALNA2;CALNB;CNA2 Q08209-1;Q08209;Q08209-2;P16298-1;P16298;P16298-3;P16298-2 ENST00000323055;ENST00000394853;ENST00000394854;ENST00000360663;ENST00000394822;ENST00000394828;ENST00000394829 K04348 5 1.1481 2.125 1.0167 1.4618 1.3654 1.3122 PH;RhoGEF cell part;cytoplasm;intracellular part enzyme regulator activity;GTPase regulator activity;guanyl-nucleotide exchange factor activity;Ras guanyl-nucleotide exchange factor activity;Rho guanyl-nucleotide exchange factor activity;small GTPase regulator activity regulation of biological process;regulation of cell communication;regulation of cellular process;regulation of Ras protein signal transduction;regulation of Rho protein signal transduction;regulation of signal transduction 8 8 8 10.1 10.1 10.1 130.81 1.0887E-141 32807000 16722000 16085000 3144 IPI:IPI00179437.6;IPI:IPI00480141.3;IPI:IPI00895907.1 Rho guanine nucleotide exchange factor 18;114 kDa Rho-specific guanine nucleotide exchange factor;p114-Rho-GEF;Septin-associated RhoGEF ARHGEF18;KIAA0521 Q6ZSZ5-1;Q6ZSZ5;Q6ZSZ5-3;Q6ZSZ5-2 ENST00000319670;ENST00000359920;ENST00000398026 3 1.4324 1.7463 1.1258 1.773 1.2486 1.4479 PB1;ZZ cell part;cytoplasmic part;cytosol;endosome;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;late endosome;membrane-bounded organelle;nucleus;organelle binding;enzyme binding;kinase binding;protein binding;protein domain specific binding;protein kinase binding;protein kinase C binding;receptor binding;receptor tyrosine kinase binding;SH2 domain binding;small conjugating protein binding;zinc ion binding apoptosis;immune response;immune system process;proteolysis;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;response to stress;transport;ubiquitin-dependent protein catabolic process 3 3 3 13.6 13.6 13.6 47.687 2.0797E-66 20481000 9605900 10875000 3146 IPI:IPI00179473.9;IPI:IPI00784104.1 Sequestosome-1;Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa;Ubiquitin-binding protein p62;EBI3-associated protein of 60 kDa SQSTM1;ORCA;OSIL Q13501-1;Q13501;Q13501-2 ENST00000389805 2 0.50605 1.4397 0.55606 0.80829 0.71314 0.87207 AT_hook cell part;chromatin;chromosomal part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex AT DNA binding;binding;DNA binding;nucleic acid binding;protein binding;receptor binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor activity;transcription factor binding chromatin organization;DNA metabolic process;DNA recombination;DNA unwinding during replication;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleosome disassembly;regulation of chromatin assembly or disassembly 3 3 2 41.1 41.1 23.4 11.676 2.9933E-34 1720900000 1059900000 660970000 3147 IPI:IPI00179700.3;IPI:IPI00746310.3 High mobility group protein HMG-I/HMG-Y;High mobility group AT-hook protein 1 HMGA1;HMGIY P17096-1;P17096;P17096-3 ENST00000311487;ENST00000357318;ENST00000360434;ENST00000374116;ENST00000374117;ENST00000395004;ENST00000401473 2 NaN 1.7615 NaN NaN 1.192 NaN KH_1;RRM_1 cell part;cytoplasm;cytoskeletal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;nucleus;organelle;organelle part binding;mRNA 5'-UTR binding;mRNA binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding;translation regulator activity anatomical structure morphogenesis;negative regulation of biosynthetic process;negative regulation of metabolic process;regulation of biosynthetic process;regulation of cytokine production;regulation of gene expression;regulation of translation 3 1 1 5.8 2 2 66.121 1.9461E-10 489300 314990 174320 3148 IPI:IPI00179713.6;IPI:IPI00743914.2;IPI:IPI00180983.1;IPI:IPI00922167.1;IPI:IPI00922068.1 Insulin-like growth factor 2 mRNA-binding protein 2;IGF-II mRNA-binding protein 2;Hepatocellular carcinoma autoantigen p62;VICKZ family member 2 IGF2BP2;IMP2;VICKZ2 Q9Y6M1-2;Q9Y6M1;Q9Y6M1-3;Q9Y6M1-1;Q9Y6M1-4;Q9Y6M1-5 ENST00000382199 5 0.67269 1.4081 0.71035 0.89045 0.91201 0.97452 SHNi-TPR;TPR_1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;heat shock protein binding;Hsp90 protein binding;protein binding blastocyst development;cell cycle;chromatin organization;chromatin remodeling;DNA metabolic process;DNA replication;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;transport 17 17 17 24.8 24.8 24.8 86.267 0 3138900000 1650900000 1488000000 3149 IPI:IPI00332499.1;IPI:IPI00179953.2;IPI:IPI00219821.3 Nuclear autoantigenic sperm protein NASP P49321-3;P49321;P49321-1;P49321-2 ENST00000350030;ENST00000351223;ENST00000402363 K11291 3 0.7732 1.449 0.80383 0.99628 0.96976 1.0054 RRM_1 heterogeneous nuclear ribonucleoprotein complex;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nucleolus;nucleoplasm;organelle;organelle part;ribonucleoprotein complex binding;nucleic acid binding;nucleotide binding;poly-pyrimidine tract binding;protein binding;RNA binding;single-stranded RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 20 20 16 62.5 62.5 57.6 57.221 0 3578000000 1921200000 1656800000 3150 IPI:IPI00179964.5;IPI:IPI00334175.3 Polypyrimidine tract-binding protein 1;Heterogeneous nuclear ribonucleoprotein I;57 kDa RNA-binding protein PPTB-1 PTBP1;PTB P26599-1;P26599;P26599-2 ENST00000349038;ENST00000356948 2 0.69411 1.4278 0.72032 0.92906 0.90154 0.97299 LsmAD;PAM2 cell part;cytoplasmic part;Golgi apparatus part;intracellular organelle part;intracellular part;macromolecular complex;organelle part;perinuclear region of cytoplasm;polysome;ribonucleoprotein complex;stress granule;trans-Golgi network binding;nucleic acid binding;protein binding;protein C-terminus binding;RNA binding cell death;cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of biosynthetic process;regulation of gene expression;regulation of translation;transport 14 14 14 15.2 15.2 15.2 140.28 6.3257E-238 122880000 66750000 56129000 3152 IPI:IPI00180154.4;IPI:IPI00455363.2;IPI:IPI00455359.2 Ataxin-2;Spinocerebellar ataxia type 2 protein;Trinucleotide repeat-containing gene 13 protein ATXN2;ATX2;SCA2;TNRC13 Q99700-1;Q99700;Q99700-4;Q99700-2 ENST00000377611;ENST00000377617;ENST00000389153 3 0.66618 1.8494 0.74807 0.97065 1.0625 1.173 Thymosin cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle actin binding;binding;cytoskeletal protein binding;protein binding cellular process;cytoskeleton organization;negative regulation of macromolecule metabolic process;negative regulation of metabolic process;organelle organization;regulation of actin polymerization or depolymerization Regulation of actin cytoskeleton 4 4 4 72.7 72.7 72.7 5.0626 2.7997E-58 9870900000 5353300000 4517500000 3153 IPI:IPI00180240.2;IPI:IPI00220828.9;IPI:IPI00719405.2;IPI:IPI00816288.1;IPI:IPI00376164.3 Thymosin beta-4-like protein 3;Thymosin beta-4;Fx;Hematopoietic system regulatory peptide;Seraspenide;Thymosin beta-4-like protein 6;Thymosin beta-4-like protein 1;Thymosin beta-4-like protein 2 TMSL3;TMSB4X;TB4X;THYB4;TMSB4;TMSL6;TMSB4L;TMSL1;TMSL2 A8MW06;P62328;A9Z1Y9;Q08EQ4;Q2KHM7 ENST00000323496;ENST00000402089;ENST00000380633;ENST00000380635;ENST00000380636;ENST00000380638 K05764 5 0.67715 1.2882 0.57548 0.90063 0.85657 0.83387 Arrestin_C;Arrestin_N cell part;cytoplasmic part;cytoplasmic vesicle;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;nucleus;organelle;plasma membrane;vesicle binding;protein binding cell communication;cell surface receptor linked signal transduction;endocytosis;enzyme linked receptor protein signaling pathway;receptor-mediated endocytosis;signal transduction;system process;transport Chemokine signaling pathway;MAPK signaling pathway 8 8 8 21.4 21.4 21.4 47.271 1.1087E-69 129380000 68909000 60466000 3154 IPI:IPI00786904.1;IPI:IPI00180375.6;IPI:IPI00783893.1 Beta-arrestin-2;Arrestin beta-2 ARRB2;ARB2;ARR2 P32121-3;P32121;P32121-1;P32121-2 ENST00000269260;ENST00000381488 K04439 3 0.67861 1.8418 NaN 0.94973 1.2427 NaN Glyco_transf_8 cell part;cytoplasmic part;cytosol;intracellular part binding;catalytic activity;glycogenin glucosyltransferase activity;protein binding;transferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring hexosyl groups;UDP-glycosyltransferase activity carbohydrate metabolic process;cellular glucan metabolic process;generation of precursor metabolites and energy;glycogen biosynthetic process;glycogen metabolic process;polysaccharide biosynthetic process;polysaccharide metabolic process 4 4 4 10.3 10.3 10.3 39.383 9.0803E-39 39806000 24230000 15576000 3155 IPI:IPI00180386.5;IPI:IPI00556308.4;IPI:IPI00794444.2 Glycogenin-1 GYG1;GYG P46976-1;P46976;P46976-2;P46976-3 ENST00000296048;ENST00000345003;ENST00000353986 K00750 3 0.4444 0.87672 0.38058 0.62211 0.5533 0.51624 Utp11 cytoplasm;extracellular space;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nucleolus;organelle;preribosome;ribonucleoprotein complex;small-subunit processome binding;protein binding cell communication;cell surface receptor linked signal transduction;induction of apoptosis;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA processing;rRNA processing;signal transduction 3 3 3 9.1 9.1 9.1 30.446 1.3512E-07 22665000 12870000 9794400 3156 IPI:IPI00180454.4 Probable U3 small nucleolar RNA-associated protein 11;UTP11-like protein UTP11L;CGI-94;HDCMB12P Q9Y3A2 ENST00000373014 1 0.72935 1.4966 0.77781 0.97191 0.95645 1.0735 MOZ_SAS;zf-C2HC cell part;histone acetyltransferase complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex acyltransferase activity;binding;catalytic activity;DNA binding;histone acetyltransferase activity;lysine N-acetyltransferase activity;N-acetyltransferase activity;nucleic acid binding;protein binding;transcription factor activity;zinc ion binding chromatin organization;DNA metabolic process;DNA replication;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein amino acid acetylation;protein modification process;regulation of transcription, DNA-dependent;transcription 6 6 5 11.3 11.3 9.5 70.642 1.6897E-73 42055000 22713000 19342000 3158 IPI:IPI00180764.3 Histone acetyltransferase MYST2;MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2;Histone acetyltransferase binding to ORC1 MYST2;HBO1;HBOa O95251 ENST00000259021 K11307 1 1.0053 NaN 0.46256 1.2115 NaN 0.54111 Pkinase_Tyr ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein tyrosine kinase activity;purine nucleoside binding;transferase activity cellular biopolymer metabolic process;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process 9 9 9 15.7 15.7 15.7 54.478 8.9522E-34 139340000 87077000 52260000 3159 IPI:IPI00180781.4;IPI:IPI00182167.4 Mixed lineage kinase domain-like protein MLKL Q8NB16-1;Q8NB16 ENST00000306247;ENST00000308807 K08849 2 0.58494 0.90693 0.55147 0.72427 0.64099 0.69875 binding;protein binding anatomical structure morphogenesis;developmental process;embryonic morphogenesis;gastrulation 2 2 2 3.6 3.6 3.6 85.816 6.405E-61 3400500 2007500 1393000 3160 IPI:IPI00414255.1;IPI:IPI00180922.9 Protein FAM48A;p38-interacting protein FAM48A;C13orf19;FP757 Q8NEM7-1;Q8NEM7;Q8NEM7-2 ENST00000350612;ENST00000356185;ENST00000360252 2 0.58167 0.96526 0.3824 0.73036 0.65482 0.5125 RRM_1 cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding response to abiotic stimulus;response to cold;response to stimulus;response to stress;response to temperature stimulus 6 6 6 41.9 41.9 41.9 18.648 3.3687E-130 168020000 93255000 74767000 3161 IPI:IPI00180954.4 Cold-inducible RNA-binding protein;Glycine-rich RNA-binding protein CIRP;A18 hnRNP CIRBP;A18HNRNP;CIRP Q14011 ENST00000320936 1 0.70736 1.2378 0.67487 0.90793 0.79465 0.92042 Brix cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;ribonucleoprotein complex binding;protein binding cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 6 6 6 26.5 26.5 26.5 33.756 3.6183E-95 237190000 176500000 60683000 3162 IPI:IPI00181116.4 U3 small nucleolar ribonucleoprotein protein IMP4;Brix domain-containing protein 4 IMP4;BXDC4 Q96G21 ENST00000259239 1 0.67752 1.1012 0.64227 0.8738 0.72023 0.79948 RRM_1 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;nucleic acid binding;nucleotide binding;RNA binding 6 6 6 14.9 14.9 14.9 48.564 2.9253E-14 94534000 48954000 45579000 3164 IPI:IPI00181617.4;IPI:IPI00930357.1 RNA-binding protein 34;RNA-binding motif protein 34 RBM34;KIAA0117 P42696-1;P42696;P42696-2 ENST00000366606 2 0.67342 NaN NaN 0.90795 NaN NaN Phosphodiest cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part catalytic activity;transferase activity cellular metabolic process;cellular process;glycerophospholipid metabolic process;lipid metabolic process;metabolic process;organophosphate metabolic process;phospholipid metabolic process;preassembly of GPI anchor in ER membrane;primary metabolic process Glycosylphosphatidylinositol(GPI)-anchor biosynthesis 2 2 2 3 3 3 118.7 1.116E-18 2779800 1569000 1210700 3165 IPI:IPI00217421.1;IPI:IPI00181620.3 GPI ethanolamine phosphate transferase 3;Phosphatidylinositol-glycan biosynthesis class O protein PIGO;UNQ632/PRO1249 Q8TEQ8-1;Q8TEQ8;Q8TEQ8-2 ENST00000341666;ENST00000361778;ENST00000378617 K05288 2 0.84992 1.2362 0.84663 1.0689 0.86233 1.0304 DUF618;RRM_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;nucleotide binding;RNA binding 4 2 2 3.9 2.3 2.3 125.87 2.0445E-44 31193000 17153000 14040000 3166 IPI:IPI00181702.3;IPI:IPI00397794.4 Splicing factor, arginine/serine-rich 15;CTD-binding SR-like protein RA4 SFRS15;KIAA1172 O95104-1;O95104;O95104-2 ENST00000286835 2 0.66353 1.2838 0.63754 0.89902 0.81422 0.85248 Brix cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;protein binding cellular component biogenesis;cellular process;ribonucleoprotein complex biogenesis;ribosome biogenesis 11 11 11 45 45 45 41.401 2.1874E-218 746090000 398590000 347510000 3167 IPI:IPI00181728.1 Brix domain-containing protein 2;Ribosome biogenesis protein Brix BXDC2;BRIX Q8TDN6 ENST00000336767 1 0.89571 1.602 0.77936 1.1684 1.0663 0.9857 Vps53_N cytoplasmic part;endosomal part;endosome membrane;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;organelle;organelle membrane;organelle part establishment of localization;establishment of protein localization;protein transport;transport 6 6 6 7.1 7.1 7.1 94.404 4.7267E-18 33081000 17267000 15814000 3168 IPI:IPI00656021.2;IPI:IPI00847977.1;IPI:IPI00181824.1 Vacuolar protein sorting-associated protein 53 homolog VPS53;PP13624 Q5VIR6-1;Q5VIR6;Q5VIR6-3;Q5VIR6-2 ENST00000291074;ENST00000389040 3 0.66595 1.4534 0.78423 0.93393 0.95137 1.0745 PHK_AB cell part;membrane;plasma membrane binding;calmodulin binding;catalytic activity;protein binding carbohydrate metabolic process;cellular glucan metabolic process;cellular process;energy reserve metabolic process;generation of precursor metabolites and energy;glycogen metabolic process;metabolic process;polysaccharide metabolic process Calcium signaling pathway;Insulin signaling pathway 3 3 3 4 4 4 124.88 1.0407E-62 9563800 5189300 4374400 3169 IPI:IPI00218571.1;IPI:IPI00514327.2;IPI:IPI00181893.1;IPI:IPI00514085.1 Phosphorylase b kinase regulatory subunit beta PHKB Q93100-1;Q93100;Q93100-3;Q93100-4;Q93100-2 ENST00000299167;ENST00000323584 K07190 4 NaN 1.0781 0.70111 NaN 0.69424 0.99801 Deme6 2 2 2 4.6 4.6 4.6 65.869 9.3598E-19 2601500 1464100 1137400 3170 IPI:IPI00827930.1;IPI:IPI00181911.4 Tetratricopeptide repeat protein 39C TTC39C;C18orf17 Q8N584-1;Q8N584;Q8N584-2 ENST00000304621 2 0.51104 0.87555 0.54539 0.70363 0.54424 0.73572 Methyltransf_12 catalytic activity;methyltransferase activity;transferase activity;transferase activity, transferring one-carbon groups Aminophosphonate metabolism;Androgen and estrogen metabolism;Histidine metabolism;Naphthalene and anthracene degradation;Selenoamino acid metabolism;Tyrosine metabolism 4 4 1 13.5 13.5 3.4 43.44 2.8909E-13 22864000 12327000 10536000 3171 IPI:IPI00853093.2;IPI:IPI00181997.9;IPI:IPI00785128.4 Methyltransferase-like protein 2B;Methyltransferase-like protein 2A METTL2B;METTL2A;METTL2;HSPC266 Q6P1Q9-1;Q6P1Q9;Q6P1Q9-2;Q96IZ6-2;Q96IZ6 ENST00000262432;ENST00000311506 K00599 3 0.29382 NaN NaN 0.38514 NaN NaN DAGK_cat cell fraction;cell part;cytoplasmic part;cytosol;insoluble fraction;intracellular part;membrane fraction;soluble fraction ATP binding;binding;calmodulin binding;catalytic activity;diacylglycerol kinase activity;DNA binding;lipid kinase activity;magnesium ion binding;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding alcohol metabolic process;anti-apoptosis;lipid metabolic process;membrane lipid metabolic process;nitrogen compound metabolic process;regulation of cell growth;regulation of muscle contraction;sphingolipid metabolic process;sphingosine metabolic process 2 1 1 3 1.7 1.7 51.084 0.0012199 2231100 1309200 921930 3172 IPI:IPI00790290.2;IPI:IPI00182048.7 Sphingosine kinase 1 SPHK1;SPHK;SPK Q9NYA1-2;Q9NYA1;Q9NYA1-1 ENST00000323374 2 0.39835 0.94107 0.8414 0.52353 0.61338 1.0871 Menin cell division site part;cell fraction;chromatin;chromosomal part;cleavage furrow;cytosol;histone methyltransferase complex;intracellular part;macromolecular complex;methyltransferase complex;nuclear matrix;organelle part;protein complex;soluble fraction binding;DNA binding;DNA secondary structure binding;double-stranded DNA binding;four-way junction DNA binding;nucleic acid binding;protein binding;protein N-terminus binding;R-SMAD binding;SMAD binding;structure-specific DNA binding;Y-form DNA binding MAPKKK cascade;negative regulation of protein amino acid phosphorylation;negative regulation of transcription from RNA polymerase II promoter;regulation of cyclin-dependent protein kinase activity;regulation of protein amino acid phosphorylation 3 3 3 4.4 4.4 4.4 67.993 6.708E-09 10689000 6305200 4383700 3173 IPI:IPI00328838.4;IPI:IPI00182106.4;IPI:IPI00651636.3 Menin MEN1;SCG2 O00255-1;O00255;O00255-2;O00255-3 ENST00000337652;ENST00000377313;ENST00000377326;ENST00000394373;ENST00000394374;ENST00000394376 3 1.0126 1.6979 1.0473 1.4051 1.1117 1.4025 PH;RhoGAP cell part;cytoplasm;intracellular part;membrane enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity biological regulation;cell communication;cellular process;regulation of biological process;regulation of cellular process;signal transduction 13 13 11 29.7 29.7 27.6 54.544 4.7956E-107 221080000 109370000 111700000 3174 IPI:IPI00182116.4 Rho GTPase-activating protein 15;Rho-type GTPase-activating protein 15;ArhGAP15 ARHGAP15;BM-024;BM-030;BM-046 Q53QZ3 ENST00000295095 1 1.213 2.0608 NaN 1.4942 1.4374 NaN Granulin extracellular region part;extracellular space binding;cytokine activity;growth factor activity;protein binding;receptor binding biological regulation;cell communication;cellular process;regulation of biological process;regulation of cellular process;signal transduction 3 3 3 6.9 6.9 6.9 63.544 4.3128E-27 7014700 3716900 3297800 3175 IPI:IPI00296713.4;IPI:IPI00182138.4 Granulins;Proepithelin;Acrogranin;Paragranulin;Granulin-1;Granulin G;Granulin-2;Granulin F;Granulin-3;Granulin B;Granulin-4;Granulin A;Granulin-5;Granulin C;Granulin-6;Granulin D;Granulin-7;Granulin E GRN P28799-1;P28799;P28799-2 ENST00000053867;ENST00000357351 2 1.1119 2.2104 1.1261 1.5224 1.5434 1.5145 FCH;SAFF 5 5 5 7 7 7 97.018 8.6637E-71 19650000 8986000 10664000 3176 IPI:IPI00642769.5;IPI:IPI00182164.7 FCH domain only protein 1 FCHO1;KIAA0290 O14526-2;O14526;O14526-1 ENST00000252771;ENST00000389133 2 0.71538 1.3998 0.85288 0.92827 0.94697 1.0184 Ribosomal_S14 cell part;cytoplasmic part;cytosolic part;cytosolic small ribosomal subunit;intracellular organelle part;intracellular part;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit binding;cation binding;ion binding;metal ion binding;protein binding;structural constituent of ribosome;structural molecule activity;transition metal ion binding;zinc ion binding biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation 2 2 2 26.8 26.8 26.8 6.6767 0.00063369 541730000 288970000 252770000 3177 IPI:IPI00182289.6 40S ribosomal protein S29 RPS29 P62273 ENST00000245458;ENST00000396020 1 0.8919 1.7786 0.89529 1.0886 1.2443 1.1148 Guanylate_kin cell part;cytoplasmic part;cytosol;intracellular part ATP binding;binding;catalytic activity;guanylate kinase activity;kinase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;nucleotide metabolic process;purine nucleotide metabolic process Purine metabolism 7 7 7 47.2 47.2 47.2 21.725 1.1225E-206 351460000 191270000 160190000 3178 IPI:IPI00182293.6 Guanylate kinase;GMP kinase GUK1;GMK Q16774 ENST00000312726;ENST00000366715;ENST00000366716;ENST00000366718;ENST00000366719;ENST00000366720;ENST00000366726;ENST00000366730;ENST00000391865 K00942 1 1.2597 1.4409 1.0742 1.5157 1.0139 1.3163 TLE_N;WD40 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding cell communication;cell surface receptor linked signal transduction;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;signal transduction;transcription 11 1 1 18.7 1.7 1.7 83.347 4.0771E-69 21025000 10982000 10043000 3179 IPI:IPI00221206.1;IPI:IPI00182478.2 Transducin-like enhancer protein 3;ESG3 TLE3;KIAA1547 Q04726-4;Q04726;Q04726-3 ENST00000317509 2 0.75304 1.2624 0.75339 0.9426 0.88584 0.98661 Ribosomal_L28e cell part;cytoplasmic part;cytosolic large ribosomal subunit;cytosolic part;intracellular organelle part;intracellular part;large ribosomal subunit;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit binding;nucleic acid binding;protein binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 5 5 5 35.8 35.8 35.8 15.747 4.5514E-25 1990300000 1082900000 907350000 3180 IPI:IPI00182533.5 60S ribosomal protein L28 RPL28 P46779 ENST00000344063 K02903 1 0.94186 1.7256 0.88726 1.2223 1.1436 1.2484 AAA;MIT;Vps4_C cytosol;early endosome;endosome;endosome membrane;intracellular organelle;late endosome membrane;lysosome;lytic vacuole;membrane;membrane-bounded organelle;nucleus;organelle;organelle membrane;vacuolar membrane;vacuole ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleoside binding;nucleotide binding;protein binding;protein C-terminus binding;purine nucleoside binding;pyrophosphatase activity ATP catabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide catabolic process;purine nucleotide metabolic process;transport 11 11 10 33.1 33.1 30.4 49.301 3.9084E-67 636720000 333850000 302870000 3181 IPI:IPI00182728.2 Vacuolar protein sorting-associated protein 4B;Suppressor of K(+) transport growth defect 1 VPS4B;SKD1;VPS42 O75351 ENST00000238497 K12196 1 0.76438 1.4021 0.77876 0.97272 0.9624 0.97447 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;mitochondrial matrix;mitochondrial part;nucleus;organelle;organelle part binding;protein binding apoptosis;cell death;cellular process;death;programmed cell death 26 26 25 33.9 33.9 33.3 102.9 0 1923200000 1005500000 917630000 3182 IPI:IPI00182757.10;IPI:IPI00873406.1;IPI:REV_IPI00020987.1 Protein KIAA1967;Deleted in breast cancer gene 1 protein;p30 DBC KIAA1967;DBC1 Q8N163-1;Q8N163;Q8N163-2 ENST00000308511;ENST00000389279 3 1.0245 1.7983 1.1054 1.3749 1.1958 1.3825 AdoHcyase;AdoHcyase_NAD cell part;cytoplasmic part;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle adenosylhomocysteinase activity;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ether bonds;trialkylsulfonium hydrolase activity cellular metabolic process;cellular process;metabolic process;one-carbon metabolic process Methionine metabolism;Selenoamino acid metabolism 16 16 8 33.4 33.4 23.4 58.951 1.1033E-83 745930000 369490000 376440000 3185 IPI:IPI00182938.8;IPI:IPI00479201.3 Putative adenosylhomocysteinase 2;S-adenosyl-L-homocysteine hydrolase 2;S-adenosylhomocysteine hydrolase-like protein 1;DC-expressed AHCY-like molecule AHCYL1;DCAL;XPVKONA O43865-1;O43865;O43865-2 ENST00000369799;ENST00000393614 K01251 2 0.93963 1.699 0.89284 1.2643 1.0882 1.2373 Ank cell part;cytoplasm;intracellular part binding;molecular transducer activity;protein binding;signal transducer activity Focal adhesion;Long-term potentiation;Regulation of actin cytoskeleton;Vascular smooth muscle contraction 20 20 20 20.7 20.7 20.7 115.28 2.6041E-199 452050000 225000000 227050000 3186 IPI:IPI00183002.6;IPI:IPI00413191.2;IPI:IPI00397730.3;IPI:IPI00397728.3 Protein phosphatase 1 regulatory subunit 12A;Myosin phosphatase-targeting subunit 1;Myosin phosphatase target subunit 1;Protein phosphatase myosin-binding subunit PPP1R12A;MBS;MYPT1 O14974-1;O14974;O14974-3;O14974-4;O14974-2 ENST00000261207;ENST00000312727;ENST00000341878;ENST00000360825 K06270 4 0.75651 NaN NaN 1.0376 NaN NaN zf-CCCH cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;nucleic acid binding;RNA binding;transition metal ion binding;zinc ion binding 4 1 1 10.5 2.9 2.9 40.517 1.1308E-10 908390 534190 374200 3187 IPI:IPI00410608.3;IPI:IPI00183078.8;IPI:IPI00744083.3 Muscleblind-like protein 2;Muscleblind-like protein-like;Muscleblind-like protein-like 39;Muscleblind-like protein 1 MBNL2;MBLL;MBLL39;MLP1 Q5VZF2-1;Q5VZF2;Q5VZF2-2;Q5VZF2-3 ENST00000343600;ENST00000345429;ENST00000376673 3 0.85889 1.5928 0.77986 1.0788 1.1042 0.98363 SIR2 cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part binding;catalytic activity;NAD+ ADP-ribosyltransferase activity;nucleotide binding;protein binding;transferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring pentosyl groups;zinc ion binding chromatin silencing;metabolic process;protein amino acid ADP-ribosylation;protein amino acid deacetylation;protein modification process;regulation of biosynthetic process;regulation of transcription, DNA-dependent 3 3 3 7.9 7.9 7.9 45.594 3.2542E-31 12672000 6855300 5817100 3188 IPI:IPI00183171.5 NAD-dependent deacetylase sirtuin-3, mitochondrial;SIR2-like protein 3 SIRT3;SIR2L3 Q9NTG7 ENST00000382743 K11413 1 0.71183 1.1997 0.73553 0.92365 0.7829 0.92396 F-box;FIST_C acid-amino acid ligase activity;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;small conjugating protein ligase activity;ubiquitin-protein ligase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein metabolic process;protein modification process;proteolysis;ubiquitin-dependent protein catabolic process 9 9 9 28 28 28 44.508 4.8762E-133 249410000 125060000 124350000 3189 IPI:IPI00183208.3;IPI:IPI00554605.1;IPI:IPI00169168.1 F-box only protein 22;F-box protein FBX22p44 FBXO22;FBX22 Q8NEZ5-1;Q8NEZ5;Q8NEZ5-2;Q8NEZ5-3 ENST00000308275 K10302 3 0.71258 1.2418 0.63449 0.93108 0.80397 0.83957 cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;organelle part;pore complex;protein complex binding;protein binding;transporter activity cellular process;establishment of protein localization;intracellular protein transport;nucleobase, nucleoside, nucleotide and nucleic acid transport;nucleocytoplasmic transport;protein export from nucleus;protein targeting;protein transport;transport 25 25 25 16.3 16.3 16.3 213.69 0 215190000 118770000 96418000 3190 IPI:IPI00900325.1;IPI:IPI00183294.4;IPI:IPI00900331.1;IPI:IPI00900318.1;IPI:IPI00646361.3 Nuclear pore complex protein Nup214;Nucleoporin Nup214;214 kDa nucleoporin;Protein CAN NUP214;CAIN;CAN;KIAA0023 P35658-3;P35658;P35658-1;P35658-4;P35658-2;P35658-5 ENST00000354226;ENST00000359428 5 0.85356 1.9291 0.86071 1.1364 1.2307 1.1527 JmjC;PHD binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding 3 3 2 3.3 3.3 2 117.86 2.6465E-69 20059000 10118000 9941200 3191 IPI:IPI00480187.2;IPI:IPI00430079.1;IPI:IPI00183302.7 PHD finger protein 8 PHF8;KIAA1111;ZNF422 Q9UPP1-1;Q9UPP1;Q9UPP1-2;Q9UPP1-3 ENST00000338154;ENST00000338946;ENST00000354751;ENST00000357988 3 0.54931 0.98652 0.4677 0.73417 0.61944 0.63372 Pkinase cell part;cytoplasmic part;cytosol;intracellular part ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cell communication;cell surface receptor linked signal transduction;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;signal transduction 12 12 12 35.9 35.9 35.9 41.937 9.7766E-71 80632000 45303000 35328000 3192 IPI:IPI00448798.6;IPI:IPI00183400.8;IPI:IPI00167096.2 Casein kinase I isoform alpha;CK1 CSNK1A1 P48729-2;P48729;P48729-1 ENST00000261798;ENST00000377843 3 0.74655 1.2956 0.71293 0.97651 0.88274 1.0115 RRM_1 cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;mRNA cap binding complex;nuclear part;nucleoplasm;organelle part;protein complex;RNA cap binding complex binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding;RNA cap binding cellular process;nucleobase, nucleoside, nucleotide and nucleic acid transport;nucleocytoplasmic transport;ribonucleoprotein complex biogenesis;RNA export from nucleus;snRNA export from nucleus;spliceosomal snRNP biogenesis;transport 5 5 5 33.3 33.3 33.3 18.001 1.8213E-16 178770000 93231000 85538000 3193 IPI:IPI00183500.2;IPI:IPI00927860.1 Nuclear cap-binding protein subunit 2;20 kDa nuclear cap-binding protein;NCBP 20 kDa subunit;NCBP-interacting protein 1;Cell proliferation-inducing gene 55 protein NCBP2;CBP20;PIG55 P52298-1;P52298;P52298-2 ENST00000321256 2 0.69114 1.6955 0.66169 0.85927 1.0929 0.83359 OTU cell part;intracellular binding;catalytic activity;cation binding;CoA hydrolase activity;cysteine-type peptidase activity;hydrolase activity;hydrolase activity, acting on ester bonds;ion binding;metal ion binding;peptidase activity;thiolester hydrolase activity;zinc ion binding catabolic process;cellular amino acid and derivative metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis Benzoate degradation via CoA ligation;Biosynthesis of unsaturated fatty acids;Limonene and pinene degradation 3 3 3 11.2 11.2 11.2 38.322 1.5739E-14 14986000 8421400 6564300 3194 IPI:IPI00183503.8;IPI:IPI00644473.2 Ubiquitin thioesterase OTU1;OTU domain-containing protein 2;DUBA-8;HIV-1-induced protease 7 YOD1;DUBA8;HIN7;OTUD2;PRO0907 Q5VVQ6-1;Q5VVQ6;Q5VVQ6-2 ENST00000315927;ENST00000391927 K01076 2 0.88291 1.9179 0.91686 1.1803 1.2343 1.2346 PX;Sorting_nexin;Vps5 cytoplasmic part;endosomal part;endosome membrane;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;organelle;organelle membrane;organelle part binding;lipid binding;phosphoinositide binding;phospholipid binding;protein binding;protein transporter activity;substrate-specific transporter activity;transporter activity cell communication;cellular component organization;cellular process;endocytosis;establishment of protein localization;intracellular protein transport;membrane invagination;membrane organization;protein transport;transport;vesicle-mediated transport 16 1 1 32.9 2.2 2.2 63.021 7.2193E-139 21826000 10768000 11058000 3195 IPI:IPI00183530.2 Sorting nexin-1 SNX1 Q13596-1;Q13596 ENST00000261889;ENST00000380285 1 0.65204 1.1367 0.59051 0.82491 0.80914 0.76868 Ded_cyto axon;basal part of cell;cell part;cell projection;growth cone;neuron projection;site of polarized growth binding;enzyme binding;enzyme regulator activity;GTP binding;GTPase regulator activity;guanyl nucleotide binding;guanyl-nucleotide exchange factor activity;nucleotide binding;protein binding;purine nucleotide binding;Ras GTPase binding;Rho GTPase binding cytoskeleton organization;microtubule cytoskeleton organization;microtubule-based process;organelle organization;positive regulation of protein amino acid phosphorylation;regulation of protein amino acid phosphorylation 5 5 5 2.5 2.5 2.5 242.56 2.682E-50 27018000 14990000 12028000 3196 IPI:IPI00513791.2;IPI:IPI00815633.1;IPI:IPI00183572.4;IPI:IPI00815886.1;IPI:IPI00807434.2;IPI:IPI00816106.3 Dedicator of cytokinesis protein 7 DOCK7;KIAA1771 Q96N67-1;Q96N67;Q96N67-6;Q96N67-2;Q96N67-5;Q96N67-3;Q96N67-4 ENST00000251157;ENST00000340370;ENST00000371140;ENST00000395441 6 0.84055 1.6307 0.90846 1.1255 1.083 1.2326 DUF2055 cell part;integral to membrane;intrinsic to membrane;membrane part 3 3 3 18.1 18.1 18.1 16.829 1.8291E-77 177340000 90041000 87302000 3197 IPI:IPI00183603.3 Oligosaccharyltransferase complex subunit OSTC;Hydrophobic protein HSF-28 OSTC;DC2;HDCMD45P;HSPC307 Q9NRP0 ENST00000361564;ENST00000394659 1 0.37185 0.68683 0.36933 0.47521 0.45963 0.47778 Cyt-b5;FA_desaturase cell fraction;endoplasmic reticulum membrane;insoluble fraction;integral to membrane;integral to plasma membrane;intracellular part;intrinsic to membrane;intrinsic to plasma membrane;membrane;membrane fraction;organelle membrane;organelle part binding;cation binding;heme binding;ion binding;iron ion binding;metal ion binding;tetrapyrrole binding;transition metal ion binding fatty acid biosynthetic process;fatty acid metabolic process;generation of precursor metabolites and energy;lipid metabolic process;metabolic process;organic acid metabolic process;transport;unsaturated fatty acid biosynthetic process alpha-Linolenic acid metabolism;Biosynthesis of unsaturated fatty acids;PPAR signaling pathway 6 6 6 16.9 16.9 16.9 52.259 1.2385E-54 288570000 162560000 126010000 3202 IPI:IPI00183786.1;IPI:IPI00023484.1;IPI:IPI00867558.1 Fatty acid desaturase 2;Delta(6) fatty acid desaturase FADS2 O95864-1;O95864;O95864-2;O95864-3 ENST00000257261;ENST00000278840 K10226 3 0.8166 0.93935 0.63497 1.0319 0.64892 0.81905 TPR_1;TPR_2 binding;protein binding 5 5 5 6.4 6.4 6.4 96.631 2.0709E-97 40261000 15385000 24876000 3203 IPI:IPI00183938.6 Tetratricopeptide repeat protein 27 TTC27 Q6P3X3 ENST00000317907 1 0.81471 NaN NaN 0.95513 NaN NaN Tropomyosin cell part;contractile fiber part;cytoplasmic part;cytoskeletal part;intracellular organelle part;intracellular part;muscle thin filament tropomyosin;organelle part actin binding;binding;cytoskeletal protein binding;protein binding biological regulation;cell motion;cellular process;regulation of biological process;regulation of multicellular organismal process;regulation of muscle contraction;regulation of system process Cardiac muscle contraction;Pathways in cancer;Thyroid cancer 19 1 1 44.9 4.6 4.6 32.95 0 82202000 39038000 43164000 3204 IPI:IPI00183968.4 Tropomyosin alpha-3 chain;Tropomyosin-3;Gamma-tropomyosin;Tropomyosin-5 TPM3 P06753-1;P06753 ENST00000271850;ENST00000330188;ENST00000368527;ENST00000368533 K09290 1 0.73406 1.765 0.58462 0.98485 1.0574 0.80747 DAO;Prenylcys_lyase extracellular region catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on sulfur group of donors;oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor catabolic process;cellular amino acid and derivative metabolic process;cellular amino acid derivative metabolic process;cellular process;metabolic process;prenylcysteine catabolic process;prenylcysteine metabolic process 4 4 4 10.9 10.9 10.9 54.672 3.8076E-43 91587000 50745000 40842000 3206 IPI:IPI00184180.3;IPI:IPI00829942.1;IPI:IPI00830094.1;IPI:IPI00830126.1 Prenylcysteine oxidase-like PCYOX1L;PSEC0105 Q8NBM8-1;Q8NBM8;Q8NBM8-2;Q8NBM8-3;Q8NBM8-4 ENST00000274569 4 0.56956 1.2679 NaN 0.76913 0.89774 NaN MR_MLE;MR_MLE_N cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle binding;catalytic activity;cation binding;ion binding;isomerase activity;magnesium ion binding;metal ion binding amine metabolic process;catabolic process;cellular amino acid and derivative metabolic process;cellular amino acid catabolic process;cellular amino acid metabolic process;metabolic process;nitrogen compound metabolic process;organic acid metabolic process 2 2 2 7 7 7 49.786 7.8372E-06 514500 329450 185050 3207 IPI:IPI00300601.5;IPI:IPI00184190.3 Mitochondrial enolase superfamily member 1;Antisense RNA to thymidylate synthase ENOSF1;RTS;TYMSAS Q7L5Y1-1;Q7L5Y1;Q7L5Y1-2 ENST00000251101;ENST00000319815;ENST00000383578 2 0.68748 1.2249 0.72129 0.87699 0.82001 0.89532 MCM cell part;chromatin;chromosomal part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding;zinc ion binding cell cycle;DNA metabolic process;DNA replication initiation;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription Cell cycle;Cell cycle - yeast;DNA replication 32 32 32 43.1 43.1 43.1 101.89 0 3277300000 1708200000 1569000000 3208 IPI:IPI00184330.5 DNA replication licensing factor MCM2;Minichromosome maintenance protein 2 homolog;Nuclear protein BM28 MCM2;BM28;CCNL1;CDCL1;KIAA0030 P49736 ENST00000265056 K02540 1 0.72757 1.2125 NaN 0.91414 0.8531 NaN cell part;integral to membrane;intrinsic to membrane;membrane part 2 2 2 3.2 3.2 3.2 72.933 3.6757E-07 4180800 2170700 2010200 3210 IPI:IPI00184376.5;IPI:IPI00646433.5 Protein SCAI;Suppressor of cancer cell invasion protein SCAI;C9orf126 Q8N9R8-2;Q8N9R8;Q8N9R8-1 ENST00000336505;ENST00000373549 2 1.2707 2.1844 1.3144 1.6704 1.4181 1.6847 DUF1055;UCH cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;cysteine-type endopeptidase activity;cysteine-type peptidase activity;endopeptidase activity;hydrolase activity;peptidase activity;protein binding;ubiquitin thiolesterase activity;ubiquitin-specific protease activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process 20 20 18 19.9 19.9 17.5 109.82 1.0926E-201 548160000 262070000 286090000 3211 IPI:IPI00184533.1 Ubiquitin carboxyl-terminal hydrolase 11;Ubiquitin thioesterase 11;Ubiquitin-specific-processing protease 11;Deubiquitinating enzyme 11 USP11;UHX1 P51784 ENST00000218348 1 0.94723 1.5995 1.2913 1.2738 1.0711 1.7311 cell part;integral to membrane;intrinsic to membrane;membrane part 2 2 2 21.6 21.6 21.6 11.748 1.8139E-07 41068000 21467000 19602000 3212 IPI:IPI00184546.4 UPF0444 transmembrane protein C12orf23 C12orf23 Q8WUH6 ENST00000280756 1 0.39343 0.49802 0.37951 0.52682 0.36128 0.49516 C1_1;C2;Pkinase;Pkinase_C ATP binding;binding;catalytic activity;kinase activity;lipid binding;nucleoside binding;nucleotide binding;protein kinase activity;protein kinase C activity;protein serine/threonine kinase activity;purine nucleoside binding;zinc ion binding cell communication;cellular process;intracellular signaling cascade;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein modification process;signal transduction Tight junction;Vascular smooth muscle contraction 5 5 5 8.3 8.3 8.3 77.828 5.1611E-11 24108000 14340000 9768300 3213 IPI:IPI00184572.5 Protein kinase C eta type;nPKC-eta;PKC-L PRKCH;PKCL;PRKCL P24723 ENST00000332981 K06068 1 0.67124 1.3662 0.61831 0.88584 0.87047 0.76587 A_deaminase AMP deaminase activity;catalytic activity;deaminase activity;hydrolase activity;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines cellular aromatic compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;purine base metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process Purine metabolism 12 12 12 12.5 12.5 12.5 100.69 3.1788E-50 216860000 116290000 100570000 3214 IPI:IPI00942246.1;IPI:IPI00184670.4;IPI:IPI00215827.1;IPI:IPI00215826.1 AMP deaminase 2;AMP deaminase isoform L AMPD2 Q01433-1;Q01433;Q01433-2;Q01433-4;Q01433-3 ENST00000256578;ENST00000342115;ENST00000358729;ENST00000369843;ENST00000393688;ENST00000393689 K01490 4 0.71872 1.1497 0.65593 0.87888 0.80119 0.86354 CoaE;CTP_transf_2 cell part;cytoplasm;intracellular part ATP binding;binding;catalytic activity;dephospho-CoA kinase activity;kinase activity;nucleoside binding;nucleotide binding;pantetheine-phosphate adenylyltransferase activity;purine nucleoside binding;transferase activity biosynthetic process;coenzyme metabolic process;group transfer coenzyme metabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process Pantothenate and CoA biosynthesis 9 9 9 21.8 21.8 21.8 65.339 1.9351E-65 100150000 53788000 46362000 3215 IPI:IPI00909064.1;IPI:IPI00184821.1 Bifunctional coenzyme A synthase;NBP;POV-2;Phosphopantetheine adenylyltransferase;Pantetheine-phosphate adenylyltransferase;Dephospho-CoA pyrophosphorylase;Dephospho-CoA kinase;Dephosphocoenzyme A kinase COASY;PSEC0106 Q13057-2;Q13057;Q13057-1 ENST00000393816;ENST00000393818 K00859;K02201 2 0.88211 1.6321 0.83161 1.1623 1.0985 1.1089 3 3 3 20.4 20.4 20.4 17.025 6.4494E-10 38894000 20018000 18876000 3216 IPI:IPI00184871.3 Uncharacterized protein C6orf130 C6orf130 Q9Y530 ENST00000244558;ENST00000373154 1 0.67936 1.1432 0.96968 0.85486 0.69393 1.2344 SMC_Nse1;zf-RING-like cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding cellular process;DNA metabolic process;DNA recombination;DNA repair;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to DNA damage stimulus;response to stress 2 2 2 12.4 12.4 12.4 30.855 1.2711E-07 31647000 17145000 14502000 3217 IPI:IPI00184884.6 Non-structural maintenance of chromosomes element 1 homolog NSMCE1;HSPC333;HSPC337 Q8WV22 ENST00000361439 1 0.72297 1.5429 0.75797 0.94988 1.0211 0.97961 IBN_N cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;organelle part;pore complex;protein complex binding;enzyme binding;GTPase binding;histone binding;protein binding;protein transporter activity;Ran GTPase binding;Ras GTPase binding;small GTPase binding;substrate-specific transporter activity;transporter activity anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;protein complex assembly;protein import into nucleus, docking 17 17 17 23.8 23.8 23.8 115.96 0 548270000 287190000 261080000 3218 IPI:IPI00185146.5 Importin-9;Ran-binding protein 9 IPO9;IMP9;KIAA1192;RANBP9;HSPC273 Q96P70 ENST00000361565 1 0.54288 0.89144 NaN 0.67174 0.55987 NaN F-box;JmjC;zf-CXXC cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;DNA binding;iron ion binding;nucleic acid binding;oxidoreductase activity;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen;protein binding;zinc ion binding chromatin organization;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;proteolysis;regulation of transcription, DNA-dependent;transcription 3 3 3 2.5 2.5 2.5 152.61 5.7578E-07 1818200 940790 877420 3219 IPI:IPI00185326.1;IPI:IPI00737594.1;IPI:IPI00747262.2 Lysine-specific demethylase 2B;JmjC domain-containing histone demethylation protein 1B;[Histone-H3]-lysine-36 demethylase 1B;F-box and leucine-rich repeat protein 10;F-box/LRR-repeat protein 10;F-box protein FBL10;Jumonji domain-containing EMSY-interactor methyltransferase motif protein;CXXC-type zinc finger protein 2;Protein-containing CXXC domain 2 KDM2B;CXXC2;FBL10;FBXL10;JHDM1B;PCCX2 Q8NHM5-1;Q8NHM5;Q8NHM5-3;Q8NHM5-2 ENST00000261824;ENST00000377071;ENST00000397480 3 0.70608 1.293 1.1011 0.90122 0.86714 1.3067 DEAD;Helicase_C ATP binding;ATP-dependent helicase activity;binding;catalytic activity;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity;RNA binding Folate biosynthesis 8 8 8 17.8 17.8 17.8 68.488 9.074E-135 157930000 73086000 84841000 3220 IPI:IPI00185361.5 ATP-dependent RNA helicase DDX55;DEAD box protein 55 DDX55;KIAA1595 Q8NHQ9 ENST00000238146 K01529 1 0.82233 1.7605 0.84794 1.0883 1.1538 1.1112 PCI cell part;cytoplasmic part;cytosol;intracellular part;macromolecular complex;proteasome regulatory particle;protein complex binding;protein binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Proteasome 31 31 31 58.1 58.1 58.1 52.904 0 1584200000 834450000 749780000 3221 IPI:IPI00185374.4;IPI:REV_IPI00796568.3;IPI:REV_IPI00002975.5 26S proteasome non-ATPase regulatory subunit 12;26S proteasome regulatory subunit p55 PSMD12 O00232 ENST00000356126 K03035 3 0.47057 1.0139 0.47852 0.66552 0.66877 0.6304 WD40 cell part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;organelle part;pore complex;protein complex cellular process;establishment of protein localization;intracellular protein transport;intracellular transport;mRNA transport;nucleic acid transport;nucleobase, nucleoside, nucleotide and nucleic acid transport;protein transport;RNA transport;transport 8 8 8 33 33 33 46.578 2.776E-80 144230000 85508000 58722000 3223 IPI:IPI00220609.3;IPI:IPI00185533.7 Nucleoporin SEH1-like;SEC13-like protein SEH1L;SEC13L;SEH1 Q96EE3-1;Q96EE3;Q96EE3-2 ENST00000262124;ENST00000399892 2 0.80132 1.3699 NaN 0.99723 0.96313 NaN DUF1055;efhand;UCH cell part;membrane binding;calcium ion binding;catalytic activity;cation binding;cysteine-type peptidase activity;hydrolase activity;hydrolase activity, acting on ester bonds;ion binding;peptidase activity;thiolester hydrolase activity;ubiquitin thiolesterase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process 3 3 3 2.1 2.1 2.1 181.65 0.00020222 9612600 4895000 4717600 3224 IPI:IPI00185661.5 Ubiquitin carboxyl-terminal hydrolase 32;Ubiquitin thioesterase 32;Ubiquitin-specific-processing protease 32;Deubiquitinating enzyme 32;Renal carcinoma antigen NY-REN-60 USP32;USP10 Q8NFA0 ENST00000300896;ENST00000393005 K11837 1 0.69379 1.4739 0.78336 0.88136 0.99809 0.97062 Tim44 intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;mitochondrial inner membrane presequence translocase complex;non-membrane-bounded organelle;organelle;protein complex;ribonucleoprotein complex;ribosome binding;primary active transmembrane transporter activity;protein binding;protein transmembrane transporter activity;protein transporter activity;structural constituent of ribosome;structural molecule activity;transporter activity biosynthetic process;cellular macromolecule biosynthetic process;cellular process;intracellular protein transport;macromolecule biosynthetic process;metabolic process;protein metabolic process;protein transport;translation;transport 6 6 6 27.8 27.8 27.8 35.351 2.4863E-31 199200000 104190000 95012000 3226 IPI:IPI00185859.2 39S ribosomal protein L45, mitochondrial MRPL45 Q9BRJ2 ENST00000312513 1 0.77845 1.3911 0.76998 1.031 0.91451 0.97582 La binding;nucleic acid binding;protein binding;RNA binding 32 32 28 41.6 41.6 38.4 123.51 3.5019E-280 1367400000 714780000 652650000 3227 IPI:IPI00185919.3;IPI:IPI00643027.1;IPI:IPI00411690.1 La-related protein 1;La ribonucleoprotein domain family member 1 LARP1;KIAA0731;LARP Q6PKG0-1;Q6PKG0;Q6PKG0-2;Q6PKG0-3 ENST00000285894;ENST00000336314;ENST00000377643 3 0.74996 1.504 0.77272 1.018 1.0511 1.0162 Kri1 7 7 7 12.3 12.3 12.3 88.194 8.8244E-183 41997000 23381000 18616000 3228 IPI:IPI00798034.2;IPI:IPI00186139.8 Protein KRI1 homolog KRI1 Q8N9T8-1;Q8N9T8;Q8N9T8-2 ENST00000312962 2 0.58628 1.1322 0.56594 0.76429 0.74263 0.74059 EFG_C;EFG_IV;GTP_EFTU;GTP_EFTU_D2 cell part;cytoplasm;intracellular part;macromolecular complex;ribonucleoprotein complex binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;nucleic acid binding;nucleotide binding;protein binding;pyrophosphatase activity;translation elongation factor activity;translation factor activity, nucleic acid binding biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation 67 67 66 69.6 69.6 68.4 95.337 0 27537000000 15799000000 11738000000 3229 IPI:IPI00186290.6 Elongation factor 2 EEF2;EF2 P13639 ENST00000309311 K03234 1 NaN 1.2049 0.37704 NaN 0.77654 0.51714 Pkinase catalytic activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;receptor signaling protein serine/threonine kinase activity activation of MAPKK activity;cell communication;intracellular signaling cascade;MAPKKK cascade;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;response to stress;signal transduction GnRH signaling pathway;MAPK signaling pathway 4 4 4 3 3 3 181.66 1.3067E-13 4193900 2663200 1530700 3230 IPI:IPI00386260.5;IPI:IPI00186536.8 Mitogen-activated protein kinase kinase kinase 4;MAPK/ERK kinase kinase 4;MAP three kinase 1 MAP3K4;KIAA0213;MAPKKK4;MEKK4;MTK1 Q9Y6R4-2;Q9Y6R4;Q9Y6R4-1 ENST00000348824;ENST00000392142 K04428 2 0.67164 1.823 NaN 0.96561 1.0467 NaN ACBP cell part;integral to membrane;intrinsic to membrane;membrane part acyl-CoA binding;binding;carboxylic acid binding;coenzyme binding;cofactor binding;fatty acid binding;lipid binding;monocarboxylic acid binding establishment of localization;transport 3 3 3 6.7 6.7 6.7 60.091 0.0026472 3636300 2167500 1468900 3231 IPI:IPI00186681.12;IPI:IPI00550377.3;IPI:IPI00644427.4;IPI:IPI00640010.2 Acyl-CoA-binding domain-containing protein 5 ACBD5;KIAA1996 Q5T8D3-1;Q5T8D3;Q5T8D3-3;Q5T8D3-2;Q5T8D3-4 ENST00000375888;ENST00000375905;ENST00000396271 4 0.99452 1.512 0.7218 1.2519 1.053 0.90806 PDZ cell fraction;cell junction;clathrin-coated vesicle;coated vesicle;cytoplasmic membrane-bounded vesicle;Golgi membrane;Golgi-associated vesicle;insoluble fraction;membrane;membrane fraction;postsynaptic density;transport vesicle binding;cystic fibrosis transmembrane conductance regulator binding;protein binding;SNARE binding;syntaxin binding;syntaxin-6 binding anatomical structure formation;asymmetric protein localization;cellular process;ER to Golgi vesicle-mediated transport;Golgi to plasma membrane transport;post-Golgi vesicle-mediated transport;protein complex assembly;protein localization;transport 9 9 9 21.6 21.6 21.6 50.519 1.1645E-32 32954000 16456000 16498000 3232 IPI:IPI00186721.2;IPI:IPI00843890.1;IPI:IPI00556252.2 Golgi-associated PDZ and coiled-coil motif-containing protein;PDZ protein interacting specifically with TC10;CFTR-associated ligand;Fused in glioblastoma GOPC;CAL;FIG Q9HD26-1;Q9HD26;Q9HD26-2;Q9HD26-3 ENST00000052569;ENST00000368498;ENST00000368499 3 0.71083 1.683 NaN 0.89154 1.0969 NaN Ank;SH3_1 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle;perinuclear region of cytoplasm binding;molecular transducer activity;NF-kappaB binding;protein binding;protein binding, bridging;protein domain specific binding;SH3 domain binding;SH3/SH2 adaptor activity;signal transducer activity;transcription factor binding apoptosis;cell communication;cell cycle;cell death;cellular process;death;induction of apoptosis;induction of programmed cell death;positive regulation of cell death;programmed cell death;regulation of cell death;signal transduction 4 4 3 4.5 4.5 3.8 125.61 2.9842E-22 6193200 3482500 2710700 3233 IPI:IPI00186808.7;IPI:IPI00337588.1 Apoptosis-stimulating of p53 protein 2;Tumor suppressor p53-binding protein 2;Bcl2-binding protein;Renal carcinoma antigen NY-REN-51 TP53BP2;ASPP2;BBP Q13625-1;Q13625;Q13625-2 ENST00000343537;ENST00000360391;ENST00000391878;ENST00000391879 2 NaN 1.2961 NaN NaN 0.91237 NaN BACK;BTB;Kelch_1 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;protein binding 3 3 3 6.3 6.3 6.3 65.991 4.7175E-26 1602400 880640 721770 3234 IPI:IPI00186843.4;IPI:IPI00643493.2 Kelch-like protein 7 KLHL7 Q8IXQ5-1;Q8IXQ5;Q8IXQ5-2 ENST00000339077 K10445 2 1.1042 2.7208 1.1024 1.4616 1.7691 1.4032 2 2 2 4.1 4.1 4.1 56.475 9.0378E-05 23507000 11525000 11982000 3235 IPI:IPI00187003.12 Uncharacterized protein C3orf19 C3orf19 Q6PII3 ENST00000383794 1 0.73434 2.1765 0.84764 1.0758 1.377 1.1856 zf-CCCH binding;cation binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding 6 6 6 9.5 9.5 9.5 140.26 9.1684E-69 29561000 16216000 13345000 3236 IPI:IPI00187011.4 Zinc finger CCCH domain-containing protein 4 ZC3H4;C19orf7;KIAA1064 Q9UPT8 ENST00000253048 1 0.92067 1.3793 1.0356 1.0935 1.0083 1.2621 Ras cell part;intracellular;membrane;plasma membrane binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleotide binding;pyrophosphatase activity cell communication;cellular process;establishment of protein localization;intracellular signaling cascade;protein transport;regulation of biological process;signal transduction;small GTPase mediated signal transduction;transport;vesicle-mediated transport 6 5 4 31 26.6 21 27.506 6.4094E-52 181090000 96347000 84744000 3239 IPI:IPI00187143.1;IPI:IPI00477489.1 Ras-related protein Rab-4B RAB4B;PP1596 P61018-2;P61018;P61018-1 ENST00000357052 K07880 2 0.77183 1.5802 0.78542 1.0047 1.0138 1.0637 Guanylate_kin;PDZ;SH3_2 cell fraction;cell projection;insoluble fraction;integral to membrane;integral to plasma membrane;intracellular part;intrinsic to membrane;intrinsic to plasma membrane;membrane fraction;membrane part;microvillus;organelle part;stereocilium binding;catalytic activity;guanylate kinase activity;kinase activity;nucleotide kinase activity;phosphotransferase activity, phosphate group as acceptor;protein binding;transferase activity;transferase activity, transferring phosphorus-containing groups biological regulation;cell communication;cellular process;regulation of biological process;regulation of cellular process;signal transduction 12 12 12 38 38 38 52.296 1.1929E-153 153460000 84720000 68745000 3240 IPI:IPI00215610.2 55 kDa erythrocyte membrane protein;Membrane protein, palmitoylated 1 MPP1;DXS552E;EMP55 Q00013 ENST00000369534 1 NaN 1.4783 NaN NaN 1.0517 NaN RHD;TIG cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;transcription factor activity;transcription regulator activity nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription;transcription, DNA-dependent Axon guidance;B cell receptor signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;VEGF signaling pathway;Wnt signaling pathway 6 1 1 10.6 1.1 1.1 77.181 2.0244E-68 1912300 1098600 813640 3241 IPI:IPI00215626.1 Nuclear factor of activated T-cells, cytoplasmic 3;T-cell transcription factor NFAT4;NFATx NFATC3;NFAT4 Q12968-5;Q12968 ENST00000329524;ENST00000346183;ENST00000349223 K04446 1 0.70829 1.2844 0.69173 0.91565 0.85873 0.89747 DEAD;Helicase_C cell part;cytoplasm;intracellular organelle;intracellular organelle part;intracellular part;membrane;membrane-bounded organelle;nuclear body;nuclear part;nuclear speck;nucleoplasm part;nucleus;organelle;organelle part;plasma membrane ATP binding;ATP-dependent RNA helicase activity;binding;catalytic activity;DNA binding;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;RNA binding;RNA helicase activity interspecies interaction between organisms;multi-organism process 37 36 36 55.6 53.9 53.9 73.243 0 2886200000 1516100000 1370100000 3242 IPI:IPI00215637.5;IPI:IPI00293616.3;IPI:IPI00071483.1;IPI:IPI00456933.1 ATP-dependent RNA helicase DDX3X;DEAD box protein 3, X-chromosomal;Helicase-like protein 2;DEAD box, X isoform;ATP-dependent RNA helicase DDX3Y;DEAD box protein 3, Y-chromosomal DDX3X;DBX;DDX3;DDX3Y;DBY O00571;O15523 ENST00000399959;ENST00000336079;ENST00000360160 K11594 4 0.63447 1.3157 0.69781 0.85886 0.8723 0.89571 Ank;Glutaminase cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part catalytic activity;glutaminase activity;hydrolase activity;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides catabolic process;cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;glutamine catabolic process;glutamine metabolic process;metabolic process;nitrogen compound metabolic process;organic acid metabolic process Arginine and proline metabolism;D-Glutamine and D-glutamate metabolism;Glutamate metabolism;Nitrogen metabolism 20 20 4 40.5 40.5 6.7 65.459 0 561850000 303080000 258770000 3243 IPI:IPI00215687.1;IPI:IPI00215685.1 Glutaminase kidney isoform, mitochondrial;L-glutamine amidohydrolase;K-glutaminase GLS;GLS1;KIAA0838 O94925-3;O94925 ENST00000320717;ENST00000338435 K01425 2 0.92964 1.9695 0.89382 1.2322 1.2895 1.2025 Sec20 envelope;integral to endoplasmic reticulum membrane;integral to membrane;integral to organelle membrane;intrinsic to endoplasmic reticulum membrane;intrinsic to membrane;intrinsic to organelle membrane;nuclear envelope;organelle envelope;SNARE complex binding;protein binding anti-apoptosis;apoptosis;cell death;cellular process;endoplasmic reticulum organization;induction of apoptosis;membrane fusion;organelle organization;positive regulation of cell death;programmed cell death;regulation of cell death;transport SNARE interactions in vesicular transport 6 6 6 30.3 30.3 30.3 26.132 2.0126E-15 185310000 92663000 92649000 3244 IPI:IPI00215704.2;IPI:IPI00030397.2;IPI:IPI00215701.2;IPI:IPI00215703.2 Vesicle transport protein SEC20;BCL2/adenovirus E1B 19 kDa protein-interacting protein 1;Transformation-related gene 8 protein BNIP1;NIP1;SEC20L;TRG8 Q12981-4;Q12981;Q12981-1;Q12981-2;Q12981-3 ENST00000231668;ENST00000351486;ENST00000352523 K08497 4 0.72556 1.2758 0.74126 0.95437 0.88553 0.9491 Ribosomal_L18e cell part;cytoplasmic part;cytosolic large ribosomal subunit;cytosolic part;intracellular organelle part;intracellular part;large ribosomal subunit;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit binding;nucleic acid binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 8 8 8 35.1 35.1 35.1 21.634 7.0876E-144 4667100000 2440200000 2226900000 3245 IPI:IPI00215719.6 60S ribosomal protein L18 RPL18 Q07020 ENST00000084795 K02883 1 0.74568 1.3948 0.83756 0.95069 0.99521 1.0344 Agenet;KH_1 cell fraction;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;nucleoplasm;organelle;organelle part;soluble fraction binding;mRNA binding;nucleic acid binding;protein binding;RNA binding establishment of localization;establishment of RNA localization;mRNA transport;nucleic acid transport;nucleobase, nucleoside, nucleotide and nucleic acid transport;RNA transport;transport 7 5 5 10.1 5.9 5.9 71.174 5.4171E-16 53525000 28426000 25099000 3246 IPI:IPI00412343.2;IPI:IPI00215721.1;IPI:IPI00783298.1;IPI:IPI00215724.1;IPI:IPI00215723.1;IPI:IPI00215720.1;IPI:IPI00215725.1;IPI:IPI00645666.1 Fragile X mental retardation 1 protein FMR1 Q06787-1;Q06787;Q06787-3;Q06787-7;Q06787-5;Q06787-4;Q06787-2;Q06787-6;Q06787-8 ENST00000218200;ENST00000370475 8 0.91253 1.8301 0.89648 1.1754 1.1443 1.2348 Rib_recp_KP_reg integral to endoplasmic reticulum membrane;integral to membrane;integral to organelle membrane;intrinsic to endoplasmic reticulum membrane;intrinsic to membrane;intrinsic to organelle membrane;macromolecular complex;ribonucleoprotein complex;ribosome molecular transducer activity;receptor activity;signal transducer activity biosynthetic process;cell communication;cellular process;intracellular protein transport;macromolecule biosynthetic process;metabolic process;protein metabolic process;protein transport;signal transduction;translation;transport 20 20 20 19 19 19 152.47 0 424230000 210500000 213730000 3247 IPI:IPI00215743.3;IPI:IPI00220967.1;IPI:IPI00744135.2;IPI:IPI00441959.1;IPI:IPI00441960.3;IPI:IPI00441955.1;IPI:IPI00441952.3;IPI:IPI00329695.4;IPI:IPI00921003.1;IPI:IPI00171791.6;IPI:IPI00883941.1 Ribosome-binding protein 1;Ribosome receptor protein;180 kDa ribosome receptor homolog;ES/130-related protein RRBP1;KIAA1398 Q9P2E9-1;Q9P2E9;Q9P2E9-2;Q9P2E9-3 ENST00000246043;ENST00000360807;ENST00000377807;ENST00000377813 11 0.83429 1.6634 0.88133 1.1115 1.1066 1.2031 GCS amino acid binding;ATP binding;binding;catalytic activity;glutamate binding;glutamate-cysteine ligase activity;ligase activity;magnesium ion binding;nucleoside binding;nucleotide binding;purine nucleoside binding cellular amino acid and derivative metabolic process;circulatory system process;organic acid metabolic process;peptide metabolic process;sulfur amino acid metabolic process;system process;vascular process in circulatory system Glutathione metabolism 5 5 5 7.2 7.2 7.2 72.765 2.4984E-15 47253000 26374000 20879000 3248 IPI:IPI00215768.3 Glutamate--cysteine ligase catalytic subunit;Gamma-glutamylcysteine synthetase;Gamma-ECS;GCS heavy chain GCLC;GLCL;GLCLC P48506 ENST00000229416 K11204 1 0.67425 1.3864 0.68958 0.91178 0.88557 0.92223 Ribosomal_S19e cytosolic small ribosomal subunit;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nucleolus;organelle;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit binding;nucleic acid binding;protein binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA processing;rRNA processing;translational elongation;transport Ribosome 12 12 12 57.2 57.2 57.2 16.06 2.4638E-59 5037500000 2648900000 2388600000 3249 IPI:IPI00215780.5 40S ribosomal protein S19 RPS19 P39019 ENST00000221975 K02966 1 0.66398 1.4474 0.65133 0.93441 0.88462 0.96807 Ribosomal_L38e cell part;cytoplasmic part;cytosolic large ribosomal subunit;cytosolic part;intracellular organelle part;intracellular part;large ribosomal subunit;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit binding;nucleic acid binding;protein binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 7 7 7 54.3 54.3 54.3 8.2178 4.6639E-66 1896600000 1012000000 884590000 3250 IPI:IPI00215790.6 60S ribosomal protein L38 RPL38 P63173 ENST00000311111 K02923 1 0.75462 1.4704 0.80505 0.99761 0.98673 1.0528 RRM_1 cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;mRNA splice site selection;ribonucleoprotein complex assembly 19 19 18 62.1 62.1 59.3 27.744 9.1922E-157 3037500000 1590000000 1447500000 3252 IPI:IPI00215884.4;IPI:IPI00218591.2;IPI:IPI00218592.5 Splicing factor, arginine/serine-rich 1;pre-mRNA-splicing factor SF2, P33 subunit;Alternative-splicing factor 1 SFRS1;ASF;SF2;SF2P33;OK/SW-cl.3 Q07955-1;Q07955;Q07955-2;Q07955-3 ENST00000258962 3 0.75075 1.7301 0.8077 1.0354 1.098 1.097 SRP72;TPR_1 cell part;cytoplasmic part;intracellular part;macromolecular complex;ribonucleoprotein complex;signal recognition particle;signal recognition particle, endoplasmic reticulum targeting 7S RNA binding;binding;nucleic acid binding;RNA binding cotranslational protein targeting to membrane;intracellular protein transport;protein targeting;protein targeting to ER;protein targeting to membrane;protein transport;SRP-dependent cotranslational protein targeting to membrane;transport Protein export 20 20 20 31.3 31.3 31.3 74.605 0 655200000 355430000 299770000 3253 IPI:IPI00215888.4 Signal recognition particle 72 kDa protein SRP72 O76094 ENST00000342756 K03108 1 0.78835 1.5583 0.88902 1.0332 1.0415 1.0914 ADK;ADK_lid cell part;cytoplasmic part;intracellular organelle part;intracellular part;membrane-enclosed lumen;mitochondrial intermembrane space;mitochondrial part;organelle envelope lumen;organelle part adenylate kinase activity;ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups cellular metabolic process;cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;primary metabolic process Purine metabolism 15 15 15 78.7 78.7 78.7 26.477 5.373E-179 1180000000 584710000 595260000 3254 IPI:IPI00215901.1;IPI:IPI00218988.4;IPI:IPI00922165.1;IPI:IPI00921960.1;IPI:IPI00172460.4;IPI:IPI00218989.2 Adenylate kinase 2, mitochondrial;ATP-AMP transphosphorylase 2 AK2;ADK2 P54819-1;P54819;P54819-2;P54819-5;P54819-6;P54819-3;P54819-4 ENST00000354858;ENST00000373449;ENST00000398192 K00939 6 0.7188 1.4475 0.73563 0.89481 0.92305 0.93655 Exo_endo_phos centrosome;endoplasmic reticulum;intracellular organelle;macromolecular complex;membrane-bounded organelle;microtubule organizing center;non-membrane-bounded organelle;nucleoplasm;organelle;ribonucleoprotein complex;ribosome catalytic activity;DNA binding;DNA-(apurinic or apyrimidinic site) lyase activity;magnesium ion binding;nuclease activity;nucleic acid binding;transcription coactivator activity;transcription cofactor activity;transcription corepressor activity base-excision repair;DNA metabolic process;DNA repair;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent Base excision repair 19 19 19 57.5 57.5 57.5 35.554 0 1756500000 932240000 824310000 3255 IPI:IPI00215911.3 DNA-(apurinic or apyrimidinic site) lyase;Apurinic-apyrimidinic endonuclease 1;APEX nuclease;Protein REF-1 APEX1;APE;APEX;APX;HAP1;REF1 P27695 ENST00000216714;ENST00000398030 K10771 1 0.95427 1.7521 1.0053 1.2607 1.1361 1.3257 Arf cell part;cytoplasmic part;cytosol;Golgi apparatus;Golgi apparatus part;Golgi membrane;intracellular organelle;intracellular organelle part;intracellular part;membrane;membrane-bounded organelle;organelle;organelle membrane;organelle part;plasma membrane binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity;receptor signaling protein activity;signal transducer activity cell communication;cellular process;intracellular signaling cascade;organelle organization;protein transport;retrograde vesicle-mediated transport, Golgi to ER;signal transduction;small GTPase mediated signal transduction;transport;vesicle coating Vibrio cholerae infection 17 17 10 73.5 73.5 40.3 20.697 4.2154E-297 3524500000 1846500000 1678000000 3256 IPI:IPI00215914.5;IPI:IPI00215917.3;IPI:IPI00888658.1 ADP-ribosylation factor 1;ADP-ribosylation factor 3 ARF1;ARF3 P84077;P61204 ENST00000272102;ENST00000327482;ENST00000391868;ENST00000256682 K07937;K07938 3 0.89968 1.7082 0.90524 1.141 1.1299 1.2132 Arf cell part;cytoplasmic part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleotide binding;pyrophosphatase activity cell communication;cellular process;establishment of protein localization;intracellular signaling cascade;protein transport;regulation of biological process;signal transduction;small GTPase mediated signal transduction;transport;vesicle-mediated transport 12 6 6 68.9 35.6 35.6 20.511 2.6892E-205 268340000 144810000 123530000 3257 IPI:IPI00215918.3;IPI:IPI00386998.2;IPI:IPI00785094.1;IPI:IPI00386996.1 ADP-ribosylation factor 4 ARF4;ARF2 P18085 ENST00000303436 K07939 4 0.83989 1.7556 0.87779 1.1233 1.1024 1.258 Arf cell part;cytoplasmic part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleotide binding;pyrophosphatase activity cell communication;cellular process;establishment of protein localization;intracellular signaling cascade;protein transport;regulation of biological process;signal transduction;small GTPase mediated signal transduction;transport;vesicle-mediated transport 12 5 5 65 31.7 31.7 20.529 1.612E-237 107940000 56858000 51080000 3258 IPI:IPI00215919.5 ADP-ribosylation factor 5 ARF5 P84085 ENST00000000233 K07940 1 0.73387 1.6096 0.72144 1.039 0.94798 0.96072 Arf cell cortex;cell fraction;cell projection;endosome;Golgi apparatus;insoluble fraction;intracellular membrane-bounded organelle;intracellular organelle;membrane;membrane fraction;membrane-bounded organelle;organelle;plasma membrane;ruffle binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity cell adhesion;cell communication;cell motion;cytoskeleton organization;intracellular signaling cascade;organelle organization;regulation of actin polymerization or depolymerization;signal transduction;small GTPase mediated signal transduction;transport 7 6 6 44.6 41.1 41.1 20.082 2.1157E-33 172430000 96732000 75699000 3259 IPI:IPI00215920.8 ADP-ribosylation factor 6 ARF6 P62330 ENST00000298316 K07941 1 0.70782 1.8106 0.74872 1.1564 1.0153 1.2273 efhand centriole;cytoplasmic part;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;microtubule organizing center part;non-membrane-bounded organelle;organelle;organelle part binding;calcium ion binding;cation binding;ion binding;metal ion binding cell cycle phase;cell cycle process;cellular component organization;cellular process;centriole replication;microtubule-based process;mitosis;nuclear division;organelle fission;organelle organization;regulation of cytokinesis Nucleotide excision repair 4 4 4 30.8 30.8 30.8 19.738 1.2652E-70 66540000 33274000 33266000 3260 IPI:IPI00215928.4;IPI:IPI00029225.1 Centrin-2;Caltractin isoform 1 CETN2;CALT;CEN2 P41208 ENST00000370277 K10840 2 0.82758 1.5195 0.75361 1.1423 0.94081 1.0154 Vinculin actin cytoskeleton;adherens junction;cell junction;cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane part;non-membrane-bounded organelle;organelle;plasma membrane part binding;cadherin binding;cell adhesion molecule binding;cytoskeletal protein binding;protein binding;structural molecule activity;vinculin binding anatomical structure formation;apical junction assembly;biological adhesion;cell adhesion;cell junction assembly;cell junction organization;cell-cell junction assembly;cellular component assembly;cellular component organization;cellular process Adherens junction;Endometrial cancer;Leukocyte transendothelial migration;Pathways in cancer;Tight junction 5 5 5 6.6 6.6 6.6 102.63 3.9933E-42 20525000 11419000 9105700 3261 IPI:IPI00473136.3;IPI:IPI00215948.4 Catenin alpha-1;Cadherin-associated protein;Alpha E-catenin;NY-REN-13 antigen CTNNA1 P35221-2;P35221;P35221-1 ENST00000302763;ENST00000355078 K05691 2 0.67792 1.127 0.74873 0.84403 0.76487 0.94251 5 5 5 5.3 5.3 5.3 136.16 1.5219E-13 32553000 17371000 15181000 3262 IPI:IPI00215963.5;IPI:IPI00807501.2;IPI:IPI00807714.2 Genetic suppressor element 1 GSE1;KIAA0182 Q14687-1;Q14687;Q14687-3;Q14687-2 ENST00000253458 3 0.74557 1.4256 0.73539 0.96918 0.92994 0.98098 RRM_1 cell part;cytoplasm;heterogeneous nuclear ribonucleoprotein complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;ribonucleoprotein complex;spliceosomal complex binding;DNA binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding;single-stranded DNA binding;single-stranded RNA binding;structure-specific DNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 25 25 25 52.4 52.4 52.4 38.845 0 11741000000 6171700000 5569200000 3263 IPI:IPI00215965.2;IPI:IPI00465365.4;IPI:IPI00797148.1;IPI:IPI00644968.1;IPI:IPI00879501.2 Heterogeneous nuclear ribonucleoprotein A1;Helix-destabilizing protein;Single-strand RNA-binding protein;Putative heterogeneous nuclear ribonucleoprotein A1-like protein 3;Heterogeneous nuclear ribonucleoprotein A1-like protein 2 HNRNPA1;HNRPA1;HNRPA1L3;HNRNPA1L2;HNRNPA1L P09651-1;P09651;P09651-2;P09651-3;P0C7M2;Q32P51 ENST00000330752;ENST00000340913;ENST00000400448;ENST00000342657;ENST00000357495;ENST00000398039 5 0.81794 1.2978 0.69445 1.0379 0.89764 0.96021 TGT cell part;cytoplasmic part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome binding;catalytic activity;cation binding;ion binding;metal ion binding;queuine tRNA-ribosyltransferase activity;transferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring pentosyl groups;zinc ion binding guanosine metabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;queuosine biosynthetic process;RNA processing;tRNA metabolic process;tRNA modification;tRNA processing 4 4 4 13.4 13.4 13.4 44.047 1.2252E-43 35317000 19591000 15726000 3266 IPI:IPI00215974.2 Queuine tRNA-ribosyltransferase;tRNA-guanine transglycosylase;Guanine insertion enzyme QTRT1;TGT;TGUT Q9BXR0 ENST00000250237 K00773 1 0.52272 1.2553 0.50647 0.71011 0.81728 0.68019 RNA_pol_Rpc4 cell part;DNA-directed RNA polymerase complex;DNA-directed RNA polymerase III complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;RNA polymerase complex binding;catalytic activity;DNA binding;DNA-directed RNA polymerase activity;nucleic acid binding;nucleotidyltransferase activity;RNA polymerase activity;transferase activity;transferase activity, transferring phosphorus-containing groups biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription;transcription from RNA polymerase III promoter;transcription, DNA-dependent RNA polymerase 2 2 2 6.3 6.3 6.3 44.395 5.9524E-14 19251000 9002100 10248000 3267 IPI:IPI00215978.4 DNA-directed RNA polymerase III subunit RPC4;DNA-directed RNA polymerase III subunit D;DNA-directed RNA polymerase III 47 kDa polypeptide;RPC53;Protein BN51 POLR3D;BN51;BN51T P05423 ENST00000306433;ENST00000397802 K03026 1 0.81639 1.891 0.9646 1.0041 1.214 1.2889 Cullin;Cullin_Nedd8 cullin-RING ubiquitin ligase complex;cytosol;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;organelle;protein complex;ubiquitin ligase complex binding;calcium channel activity;cation channel activity;cation transmembrane transporter activity;ion channel activity;ion transmembrane transporter activity;protein binding;receptor activity;signal transducer activity;transporter activity cell cycle arrest;cell proliferation;G1/S transition of mitotic cell cycle;induction of apoptosis;metabolic process;negative regulation of cell proliferation;proteolysis;ubiquitin-dependent protein catabolic process Ubiquitin mediated proteolysis 14 14 14 19.8 19.8 19.8 96.725 9.3301E-146 793410000 412880000 380530000 3269 IPI:IPI00216003.4 Cullin-5;Vasopressin-activated calcium-mobilizing receptor;VACM-1 CUL5;VACM1 Q93034 ENST00000299351 K10612 1 0.66781 1.2816 0.70649 0.88445 0.88078 0.90518 G6PD_C;G6PD_N centrosome;cytosol;internal side of plasma membrane;intracellular membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;microtubule organizing center;non-membrane-bounded organelle;organelle binding;catalytic activity;glucose binding;glucose-6-phosphate dehydrogenase activity;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;protein binding;sugar binding alcohol metabolic process;carbohydrate metabolic process;cytokine production;D-ribose metabolic process;glucose 6-phosphate utilization;glucose metabolic process;monosaccharide metabolic process;peptide metabolic process Glutathione metabolism;Pentose phosphate pathway 30 30 30 59.7 59.7 59.7 63.826 0 2472800000 1356900000 1116000000 3270 IPI:IPI00216008.4;IPI:IPI00853547.1;IPI:IPI00289800.7 Glucose-6-phosphate 1-dehydrogenase G6PD P11413-2;P11413;P11413-3;P11413-1 ENST00000291567;ENST00000369620;ENST00000393562;ENST00000393564 K00036 3 0.74664 1.6972 0.75032 1.0037 1.1134 0.98638 Porin_3 integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial membrane;mitochondrial nucleoid;mitochondrial outer membrane;nucleoid;organelle membrane;organelle outer membrane;organelle part;outer membrane anion channel activity;anion transmembrane transporter activity;binding;ion channel activity;nucleotide binding;protein binding;transporter activity;voltage-gated anion channel activity;voltage-gated ion channel activity anion transport;establishment of localization;ion transport;transport Calcium signaling pathway;Huntington's disease;Parkinson's disease 15 15 15 60.9 60.9 60.9 31.566 1.3066E-291 3579100000 1922200000 1656900000 3271 IPI:IPI00216026.2;IPI:IPI00902560.1;IPI:IPI00024145.2 Voltage-dependent anion-selective channel protein 2;Outer mitochondrial membrane protein porin 2 VDAC2 P45880-3;P45880;P45880-1;P45880-2 ENST00000298468;ENST00000332211;ENST00000344036 K05862 3 0.8959 1.4181 NaN 1.207 0.88594 NaN HAND;Helicase_C;SLIDE;SNF2_N cell part;chromatin remodeling complex;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex ATP binding;binding;catalytic activity;chromatin binding;DNA binding;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity brain development;chromatin organization;chromatin remodeling;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;regulation of transcription, DNA-dependent;transcription 14 2 2 11.7 2.2 2.2 124.33 9.918E-77 37321000 10997000 26324000 3272 IPI:IPI00216046.3;IPI:IPI00646130.2 Probable global transcription activator SNF2L1;Nucleosome-remodeling factor subunit SNF2L;ATP-dependent helicase SMARCA1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1 SMARCA1;SNF2L;SNF2L1 P28370-1;P28370;P28370-2 ENST00000371121;ENST00000371122 K11727 2 0.72358 1.961 0.8032 0.99607 1.185 1.0498 IP_trans cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;lipid transporter activity;phosphatidylcholine transmembrane transporter activity;phosphatidylinositol transporter activity;phospholipid transporter activity;protein binding;substrate-specific transporter activity;transporter activity cognition;lipid metabolic process;metabolic process;multicellular organismal process;neurological system process;primary metabolic process;sensory perception;sensory perception of light stimulus;system process;transport;visual perception 6 5 5 28.5 25.2 25.2 31.806 1.3012E-31 181900000 99674000 82227000 3273 IPI:IPI00216048.9 Phosphatidylinositol transfer protein alpha isoform PITPNA;PITPN Q00169 ENST00000313486 1 0.76567 1.4347 0.77543 1.0104 0.94172 1.0061 KH_1;ROKNT cell part;cytoplasm;heterogeneous nuclear ribonucleoprotein complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;ribonucleoprotein complex;spliceosomal complex binding;DNA binding;nucleic acid binding;protein binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 29 29 2 59.3 59.3 8 51.028 0 13856000000 7156700000 6699200000 3274 IPI:IPI00216746.1;IPI:IPI00216049.1 Heterogeneous nuclear ribonucleoprotein K;Transformation up-regulated nuclear protein HNRNPK;HNRPK P61978-2;P61978;P61978-1 ENST00000351839;ENST00000360384;ENST00000376258;ENST00000376263;ENST00000376281 2 0.70204 1.2556 0.66976 0.9643 0.80236 0.90128 ADH_N;ADH_zinc_N cell fraction;cell part;extracellular region part;extracellular space;insoluble fraction;membrane fraction;soluble fraction binding;catalytic activity;L-iditol 2-dehydrogenase activity;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;sugar binding;zinc ion binding alcohol metabolic process;carbohydrate metabolic process;cell motion;fructose metabolic process;glucose metabolic process;hexitol metabolic process;metabolic process;monosaccharide metabolic process;sorbitol catabolic process;sorbitol metabolic process Fructose and mannose metabolism 12 12 12 44.3 44.3 44.3 38.296 0 550330000 294370000 255960000 3275 IPI:IPI00216057.5 Sorbitol dehydrogenase;L-iditol 2-dehydrogenase SORD Q00796 ENST00000267814 K00008 1 0.8575 1.404 0.90768 1.0522 0.94729 1.1337 COX6B cell part;cytoplasmic part;intracellular organelle part;intracellular part;membrane-enclosed lumen;mitochondrial intermembrane space;mitochondrial part;organelle envelope lumen;organelle part catalytic activity;cation transmembrane transporter activity;cytochrome-c oxidase activity;heme-copper terminal oxidase activity;ion transmembrane transporter activity;monovalent inorganic cation transmembrane transporter activity;transporter activity metabolic process;oxidation reduction Alzheimer's disease;Cardiac muscle contraction;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 4 4 4 58.1 58.1 58.1 10.192 3.5716E-64 646850000 327740000 319100000 3276 IPI:IPI00216085.3 Cytochrome c oxidase subunit 6B1;Cytochrome c oxidase subunit VIb isoform 1 COX6B1;COX6B P14854 ENST00000246554;ENST00000392201 K02267 1 0.12841 8.7814 0.031241 0.16182 5.9409 0.039717 Cadherin;Cadherin_pro anchoring junction;cell fraction;cell junction;cell part;cell-cell junction;desmosome;gap junction;insoluble fraction;integral to membrane;intrinsic to membrane;membrane fraction;membrane part;plasma membrane part binding;calcium ion binding;cation binding;ion binding;metal ion binding;protein binding biological adhesion;cell adhesion;cell-cell adhesion;cellular process;homophilic cell adhesion + 7 7 7 9.7 9.7 9.7 99.986 7.242E-35 59029000 55667000 3362700 3277 IPI:IPI00216099.3;IPI:IPI00386975.3 Desmocollin-1;Desmosomal glycoprotein 2/3;DG2/DG3 DSC1;CDHF1 Q08554-1;Q08554;Q08554-2 ENST00000257197;ENST00000257198 2 0.47405 NaN NaN 0.64036 NaN NaN BTB;zf-C2H2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transcription factor activity;transcription regulator activity;transition metal ion binding;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 2 2 2 3.5 3.5 3.5 71.421 1.1468E-18 3038100 1761300 1276800 3278 IPI:IPI00658062.1;IPI:IPI00216100.6 Zinc finger protein 131 ZNF131 P52739-1;P52739;P52739-2 ENST00000306938;ENST00000399534 2 NaN 0.99623 NaN NaN 0.63591 NaN MMR_HSR1;YchF-GTPase_C cell part;cytoplasm;intracellular part adenyl nucleotide binding;ATP binding;binding;catalytic activity;GTP binding;guanyl nucleotide binding;hydrolase activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;ribonucleotide binding ATP catabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide catabolic process;purine nucleotide metabolic process 17 1 1 49.6 2.5 2.5 31.44 0 1529500 838890 690650 3279 IPI:IPI00216106.3 Obg-like ATPase 1;GTP-binding protein 9 OLA1;GTPBP9;PTD004;PRO2455 Q9NTK5-3;Q9NTK5 ENST00000284719;ENST00000344357;ENST00000392560;ENST00000409546 K06942 1 0.40713 0.86601 0.48005 0.50192 0.52838 0.59814 Pkinase;Pkinase_C cell fraction;cell junction;cell part;cytoplasmic part;cytosol;insoluble fraction;intracellular part;membrane fraction;membrane part;plasma membrane part;synapse;synaptosome ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cell communication;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process;signal transduction Acute myeloid leukemia;ErbB signaling pathway;Insulin signaling pathway;mTOR signaling pathway;TGF-beta signaling pathway 7 7 7 16.4 16.4 16.4 59.139 3.3422E-22 43279000 23754000 19525000 3280 IPI:IPI00216132.1;IPI:IPI00759649.1 Ribosomal protein S6 kinase beta-1;Ribosomal protein S6 kinase I;S6K1;70 kDa ribosomal protein S6 kinase 1;p70 S6 kinase alpha RPS6KB1;STK14A P23443-1;P23443;P23443-2 ENST00000225577 K04688 2 0.76088 1.4919 NaN 0.99182 0.93452 NaN SCP-1 binding;DNA binding;nucleic acid binding;protein binding DNA metabolic process;DNA recombination;gamete generation;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;reciprocal meiotic recombination;synaptonemal complex assembly 2 2 2 2.8 2.8 2.8 114.19 0.0061188 2116900 2078600 38224 3281 IPI:IPI00216137.4 Synaptonemal complex protein 1;Cancer/testis antigen 8 SYCP1;SCP1 Q15431 ENST00000369518;ENST00000369522 1 0.85756 1.5838 0.87884 1.1291 1.009 1.1523 Septin cytoplasmic part;cytoskeletal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;organelle part;protein complex;septin complex binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;protein binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cell cycle;cell division;cellular process;cytokinesis 19 19 10 47.2 47.2 30.4 49.716 0 2668200000 1414700000 1253500000 3282 IPI:IPI00941331.1;IPI:IPI00744597.2;IPI:IPI00216139.3;IPI:IPI00376992.5 Septin-6 SEPT6;KIAA0128;SEP2 Q14141-1;Q14141;Q14141-4;Q14141-2;Q14141-3 ENST00000343984;ENST00000360156;ENST00000371478;ENST00000371493;ENST00000394610;ENST00000394612;ENST00000394616 4 0.79486 NaN NaN 1.086 NaN NaN GATase_2;SIS cell part;cytoplasm;intracellular part binding;carbohydrate binding;catalytic activity;glutamine-fructose-6-phosphate transaminase (isomerizing) activity;sugar binding;transaminase activity;transferase activity;transferase activity, transferring nitrogenous groups alcohol metabolic process;carbohydrate metabolic process;fructose 6-phosphate metabolic process;fructose metabolic process;generation of precursor metabolites and energy;monosaccharide metabolic process;organic acid metabolic process Aminosugars metabolism;Glutamate metabolism 7 2 2 13.2 3.4 3.4 76.93 9.9862E-88 836890 513750 323140 3283 IPI:IPI00216159.14 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2;Glutamine:fructose 6 phosphate amidotransferase 2;D-fructose-6-phosphate amidotransferase 2;Hexosephosphate aminotransferase 2 GFPT2 O94808 ENST00000253778 K00820 1 0.77824 1.4325 0.77152 1.0144 0.96903 0.99225 Enolase_C;Enolase_N cell part;cytoplasmic part;cytosolic part;intracellular part;macromolecular complex;membrane;phosphopyruvate hydratase complex;plasma membrane;protein complex binding;carbon-oxygen lyase activity;catalytic activity;cation binding;hydro-lyase activity;ion binding;lyase activity;magnesium ion binding;metal ion binding;phosphopyruvate hydratase activity alcohol metabolic process;carbohydrate metabolic process;catabolic process;cellular process;generation of precursor metabolites and energy;glucose catabolic process;glucose metabolic process;glycolysis;metabolic process;monosaccharide metabolic process Glycolysis / Gluconeogenesis 16 12 10 51.6 43.1 35.9 47.268 0 934470000 482130000 452340000 3284 IPI:IPI00216171.3 Gamma-enolase;2-phospho-D-glycerate hydro-lyase;Neural enolase;Neuron-specific enolase;Enolase 2 ENO2 P09104 ENST00000229277 K01689 1 0.89322 1.3186 0.91429 1.2112 0.85998 1.1723 ANTH clathrin coat;clathrin-coated vesicle;coated pit;coated vesicle;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;Golgi apparatus;macromolecular complex;membrane coat;membrane-bounded organelle;membrane-bounded vesicle;organelle;vesicle binding;clathrin binding;lipid binding;phosphatidylinositol binding;phosphoinositide binding;phospholipid binding;protein binding anatomical structure formation;cellular component organization;cellular process;endocytosis;membrane invagination;membrane organization;organelle organization;protein complex assembly;receptor-mediated endocytosis;transport;vesicle coating 10 10 10 19.6 19.6 19.6 70.754 1.6019E-186 99381000 52890000 46491000 3285 IPI:IPI00290738.4;IPI:IPI00216184.3;IPI:IPI00400849.2;IPI:IPI00006612.2;IPI:IPI00470905.2;IPI:IPI00646376.2 Phosphatidylinositol-binding clathrin assembly protein;Clathrin assembly lymphoid myeloid leukemia protein PICALM;CALM Q13492-1;Q13492;Q13492-2;Q13492-3 ENST00000341783;ENST00000349405;ENST00000356360;ENST00000393343 6 0.69992 1.3469 0.7799 0.9244 0.90716 1.0288 AAA_2;Ank;ClpB_D2-small ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity cellular process;cellular response to heat;cellular response to stimulus;cellular response to stress;response to abiotic stimulus;response to heat;response to stimulus;response to stress;response to temperature stimulus 31 31 31 52.9 52.9 52.9 75.448 1.4391E-228 498720000 276820000 221910000 3286 IPI:IPI00216192.3;IPI:IPI00006615.3 Caseinolytic peptidase B protein homolog;Suppressor of potassium transport defect 3 CLPB;HSP78;SKD3 Q9H078-2;Q9H078;Q9H078-1 ENST00000294053;ENST00000340729 K03695 2 0.81557 1.6743 0.86233 1.0665 1.1119 1.1012 LEM;Thymopoietin cell part;chromatin;chromosomal part;envelope;intracellular organelle part;intracellular part;nuclear envelope;nuclear part;organelle envelope;organelle part binding;DNA binding;lamin binding;nucleic acid binding;protein binding 27 27 17 52.3 52.3 37.9 75.491 0 2069800000 1080600000 989190000 3287 IPI:IPI00216230.3 Lamina-associated polypeptide 2, isoform alpha;Thymopoietin isoform alpha;Thymopoietin-related peptide isoform alpha;Thymopoietin;Splenin;Thymopentin;TP5 TMPO;LAP2 P42166 ENST00000266732 1 0.68255 1.3479 0.75669 0.90253 0.88589 1.0243 Ribosomal_L36e cytosolic large ribosomal subunit;intracellular non-membrane-bounded organelle;intracellular organelle;large ribosomal subunit;macromolecular complex;non-membrane-bounded organelle;nucleolus;organelle;ribonucleoprotein complex;ribosomal subunit binding;protein binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation 11 11 11 41.9 41.9 41.9 12.254 1.8161E-86 3098400000 1634600000 1463900000 3288 IPI:IPI00216237.5 60S ribosomal protein L36 RPL36 Q9Y3U8 ENST00000347512;ENST00000394580 1 0.7473 1.5276 0.80239 1.0038 1.0346 1.0754 Thioredoxin cell part;cytoplasmic part;cytosol;intracellular part binding;protein binding cell communication;cell motion;cell proliferation;cell-cell signaling;cellular homeostasis;cellular process;electron transport chain;generation of precursor metabolites and energy;homeostatic process;metabolic process;signal transduction;transport 7 7 7 51.4 51.4 51.4 11.737 8.9309E-79 3349700000 1766100000 1583600000 3289 IPI:IPI00216298.6 Thioredoxin;ATL-derived factor;Surface-associated sulphydryl protein TXN;TRDX;TRX;TRX1 P10599 ENST00000374517 K03671 1 0.75293 1.5597 0.73188 0.99869 1.0295 0.96323 Porin_3 cytoplasmic part;intracellular part;membrane;membrane part;mitochondrial membrane;mitochondrial nucleoid;mitochondrial outer membrane;mitochondrial part;nucleoid;organelle membrane;organelle outer membrane;organelle part;outer membrane;plasma membrane anion channel activity;anion transmembrane transporter activity;binding;ion channel activity;ion transmembrane transporter activity;protein binding;transporter activity;voltage-gated anion channel activity;voltage-gated ion channel activity anion transport;apoptosis;cell death;cellular process;death;establishment of localization;interspecies interaction between organisms;ion transport;multi-organism process;programmed cell death;transport Calcium signaling pathway;Huntington's disease;Parkinson's disease 18 18 18 68.2 68.2 68.2 30.772 0 5114200000 2757300000 2356900000 3290 IPI:IPI00216308.5 Voltage-dependent anion-selective channel protein 1;Outer mitochondrial membrane protein porin 1;Plasmalemmal porin;Porin 31HL;Porin 31HM VDAC1;VDAC P21796 ENST00000265333;ENST00000395044;ENST00000395047 K05862 1 0.83713 1.6526 0.81265 1.1579 1.0582 1.0656 14-3-3 centrosome;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;cytosol;intracellular organelle;melanosome;membrane-bounded organelle;membrane-bounded vesicle;microtubule organizing center;non-membrane-bounded organelle;nucleus;organelle;vesicle binding;enzyme binding;protein binding;protein domain specific binding activation of pro-apoptotic gene products;cell communication;cellular process;intracellular signaling cascade;negative regulation of metabolic process;Ras protein signal transduction;signal transduction;small GTPase mediated signal transduction Cell cycle 19 17 2 62.6 62.6 4.5 28.082 0 2053300000 1072300000 980960000 3291 IPI:IPI00216318.5;IPI:IPI00013890.2;IPI:IPI00411765.3 14-3-3 protein beta/alpha;Protein kinase C inhibitor protein 1;Protein 1054;14-3-3 protein beta/alpha, N-terminally processed YWHAB P31946-1;P31946 ENST00000353703;ENST00000372839 K06630 3 0.74198 1.4773 0.77666 0.96399 0.93972 1.086 14-3-3 cell part;cytoplasm;intracellular part binding;enzyme binding;insulin-like growth factor receptor binding;nuclear hormone receptor binding;protein binding;protein domain specific binding;receptor binding;transcription activator activity;transcription regulator activity cell communication;glucocorticoid catabolic process;intracellular protein transport;intracellular signaling cascade;lipid metabolic process;metabolic process;signal transduction;steroid catabolic process;steroid metabolic process;transport Cell cycle 16 14 14 46.3 42.3 42.3 28.218 3.5988E-301 1271400000 660320000 611130000 3292 IPI:IPI00216319.3 14-3-3 protein eta;Protein AS1 YWHAH;YWHA1 Q04917 ENST00000248975 K06630 1 0.82858 1.5182 0.79303 1.0968 0.97725 1.0774 DIM1 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex catalytic activity;RNA splicing factor activity, transesterification mechanism anatomical structure formation;cell cycle phase;cell cycle process;cellular component assembly;cellular component organization;cellular process;mitosis;nuclear division;organelle organization;ribonucleoprotein complex assembly;spliceosome assembly 2 2 2 15.5 15.5 15.5 16.786 1.7772E-31 91719000 47332000 44387000 3293 IPI:IPI00216338.4 Thioredoxin-like protein 4A;Thioredoxin-like U5 snRNP protein U5-15kD;Spliceosomal U5 snRNP-specific 15 kDa protein;DIM1 protein homolog TXNL4A;DIM1;TXNL4 P83876 ENST00000269601 1 0.89519 1.6657 0.89828 1.1907 1.0617 1.1705 WD40 cell part;cytoplasm;cytoskeletal part;dynein complex;intracellular organelle part;intracellular part;macromolecular complex;microtubule;microtubule associated complex;organelle part;protein complex binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;microtubule motor activity;motor activity;protein binding;pyrophosphatase activity cellular process;microtubule-based movement;microtubule-based process 9 9 9 21.6 21.6 21.6 68.426 9.7852E-148 335460000 171530000 163920000 3294 IPI:IPI00216348.1;IPI:IPI00827813.1;IPI:IPI00744015.1;IPI:IPI00827859.1;IPI:IPI00302712.4 Cytoplasmic dynein 1 intermediate chain 2;Cytoplasmic dynein intermediate chain 2;Dynein intermediate chain 2, cytosolic;DH IC-2 DYNC1I2;DNCI2;DNCIC2 Q13409-3;Q13409;Q13409-6;Q13409-1;Q13409-5;Q13409-2 ENST00000263811;ENST00000340296;ENST00000358002;ENST00000397119;ENST00000409773;ENST00000410079 K10415 5 0.62394 1.1487 0.6623 0.85135 0.75213 0.88217 zf-C2H2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding biosynthetic process;mesoderm development;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 8 8 1 22.4 22.4 4.2 52.705 2.4795E-225 682380000 356270000 326110000 3296 IPI:IPI00216392.1 DNA-binding protein Ikaros;Ikaros family zinc finger protein 1;Lymphoid transcription factor LyF-1 IKZF1;IK1;IKAROS;LYF1;ZNFN1A1 Q13422-7;Q13422 ENST00000331340;ENST00000343574;ENST00000346667;ENST00000349824;ENST00000357364;ENST00000359197 K09220 1 1.4833 1.5292 1.5513 1.9632 0.96538 2.0467 LIM;PDZ;Pkinase cell part;cytoplasm;intracellular part ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;protein tyrosine kinase activity;purine nucleoside binding;transferase activity;zinc ion binding cell communication;cytoskeleton organization;intracellular signaling cascade;organelle organization;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;signal transduction Axon guidance;Regulation of actin cytoskeleton 2 2 2 4.2 4.2 4.2 72.584 4.2299E-16 85665000 40537000 45129000 3297 IPI:IPI00291702.2;IPI:IPI00216433.2;IPI:IPI00216434.1 LIM domain kinase 1 LIMK1;LIMK P53667-1;P53667;P53667-2;P53667-3 ENST00000336180 K05743 3 0.59713 1.8622 0.68621 0.88149 1.0907 0.95197 Histone cell part;chromosomal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;macromolecular complex;membrane-bounded organelle;nucleosome;nucleus;organelle;organelle part;protein-DNA complex binding;DNA binding;nucleic acid binding anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;chromatin organization;nucleosome assembly;organelle organization Systemic lupus erythematosus 8 3 1 60.8 36.2 22.3 14.095 1.5819E-197 406630000 216940000 189690000 3298 IPI:IPI00216457.7;IPI:IPI00339274.5 Histone H2A type 2-A;H2A/o;Histone H2A type 2-C;H2A-GL101;H2A/q HIST2H2AA3;H2AFO;HIST2H2AA;HIST2H2AA4;HIST2H2AC;H2AFQ Q6FI13;Q16777 ENST00000369159;ENST00000369161;ENST00000331380 K11251 2 0.79337 1.4514 NaN 1.007 0.94675 NaN binding 2 2 2 3.3 3.3 3.3 91.761 9.8799E-42 5061900 3006700 2055200 3300 IPI:IPI00829927.1;IPI:IPI00216484.6 LisH domain-containing protein ARMC9;Melanoma/melanocyte specific protein KU-MEL-1;NS21 ARMC9;KIAA1868 Q7Z3E5-1;Q7Z3E5;Q7Z3E5-2 ENST00000349938 2 1.0426 1.6248 1.1489 1.3199 1.1176 1.4654 Arfaptin cell part;cytoplasmic part;cytosol;Golgi apparatus part;Golgi membrane;intracellular organelle part;intracellular part;membrane;organelle membrane;organelle part establishment of protein localization;intracellular protein transport;intracellular transport;protein transport;regulation of biological process;regulation of localization;regulation of protein localization;regulation of protein secretion;transport 6 6 6 23.5 23.5 23.5 38.598 2.7888E-46 22518000 11259000 11259000 3301 IPI:IPI00216520.1;IPI:IPI00021258.2 Arfaptin-1;ADP-ribosylation factor-interacting protein 1 ARFIP1 P53367-2;P53367;P53367-1 ENST00000353617;ENST00000356064;ENST00000405727;ENST00000408000 2 0.69241 1.3559 0.71928 0.92768 0.92317 0.92293 Ribosomal_S8e cell part;cytoplasmic part;cytosolic part;cytosolic small ribosomal subunit;intracellular organelle part;intracellular part;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit binding;protein binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 18 18 18 59.6 59.6 59.6 24.205 0 9089100000 4796300000 4292800000 3303 IPI:IPI00216587.9 40S ribosomal protein S8 RPS8;OK/SW-cl.83 P62241 ENST00000372214;ENST00000396651 K02995 1 0.7138 1.6409 0.78126 0.96734 1.0348 1.043 RRM_1 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;identical protein binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 17 17 8 44 44 30 32.337 0 13342000000 7071300000 6270900000 3304 IPI:IPI00216592.2;IPI:IPI00477313.3;IPI:IPI00759596.1;IPI:IPI00759822.1 Heterogeneous nuclear ribonucleoproteins C1/C2 HNRNPC;HNRPC P07910-2;P07910;P07910-1;P07910-4;P07910-3 ENST00000216296;ENST00000320084;ENST00000336053 4 0.64512 NaN NaN 0.94849 NaN NaN cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding biosynthetic process;cellular process;defense response;glycoprotein biosynthetic process;glycoprotein metabolic process;macromolecule biosynthetic process;metabolic process;pathogenesis;protein metabolic process;response to stress;translation 3 3 3 6.3 6.3 6.3 71.863 0.0032076 3000300 1958000 1042300 3305 IPI:IPI00783750.1;IPI:IPI00216616.1 TNFAIP3-interacting protein 1;Nef-associated factor 1;HIV-1 Nef-interacting protein;Virion-associated nuclear shuttling protein;Nip40-1 TNIP1;KIAA0113;NAF1 Q15025-1;Q15025;Q15025-2 ENST00000315050;ENST00000389378 2 0.66818 1.1908 0.61018 0.89495 0.79576 0.79379 SRP40_C cell part;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part adenyl nucleotide binding;ATP binding;binding;GTP binding;guanyl nucleotide binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cellular component organization;cellular process;metabolic process;mitosis;nitrogen compound metabolic process;nuclear division;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;RNA processing;rRNA processing 8 8 8 12.4 12.4 12.4 74.746 9.0965E-80 687140000 348080000 339060000 3306 IPI:IPI00216654.2;IPI:IPI00292387.6;IPI:IPI00908873.1 Nucleolar phosphoprotein p130;Nucleolar 130 kDa protein;140 kDa nucleolar phosphoprotein;Nucleolar and coiled-body phosphoprotein 1;HCV NS5A trans-regulated protein 13 NOLC1;KIAA0035 Q14978-2;Q14978;Q14978-1;Q14978-3 ENST00000370007;ENST00000405356 3 1.2363 2.3169 1.2587 1.6571 1.596 1.6771 Peptidase_C14 cell part;cytoplasmic part;cytosol;endoplasmic reticulum membrane;endoplasmic reticulum part;intracellular organelle part;intracellular part;membrane;membrane part;mitochondrial membrane;mitochondrial part;organelle membrane;organelle part binding;catalytic activity;cysteine-type endopeptidase activity;cysteine-type peptidase activity;endopeptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides;protein binding apoptosis;catabolic process;cell death;cellular process;death;macromolecule catabolic process;macromolecule metabolic process;metabolic process;programmed cell death;protein catabolic process;protein metabolic process;proteolysis Alzheimer's disease;Apoptosis 5 5 5 14.6 14.6 14.6 37.814 1.1116E-12 90300000 42652000 47649000 3307 IPI:IPI00216675.1;IPI:IPI00221307.1;IPI:IPI00216674.1 Caspase-7;ICE-like apoptotic protease 3;Apoptotic protease Mch-3;CMH-1;Caspase-7 subunit p20;Caspase-7 subunit p11 CASP7;MCH3 P55210-3;P55210;P55210-1 ENST00000298700;ENST00000345633;ENST00000369315;ENST00000369318;ENST00000369321;ENST00000369331;ENST00000393012 K04397 3 0.63848 1.5819 NaN 0.89409 0.97023 NaN Calponin;CH actin binding;binding;calmodulin binding;cytoskeletal protein binding;protein binding;tropomyosin binding;troponin C binding actin cytoskeleton organization;actin filament-based process;cellular component organization;cellular process;cytoskeleton organization;muscle contraction;muscle system process;organelle organization;smooth muscle contraction;system process 2 1 1 6.7 3.3 3.3 36.413 7.0897E-11 16821000 9147200 7673400 3308 IPI:IPI00216682.5 Calponin-3;Calponin, acidic isoform CNN3 Q15417 ENST00000370206;ENST00000394202 1 0.81437 1.3889 0.75072 1.0246 0.95346 0.99476 KH_1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;ribonucleoprotein complex binding;DNA binding;nucleic acid binding;protein binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 14 14 10 58.9 58.9 47.4 38.58 0 7672100000 3974500000 3697600000 3309 IPI:IPI00216689.2 Poly(rC)-binding protein 2;Alpha-CP2 PCBP2 Q15366 ENST00000359462 1 0.87166 1.6378 0.84932 1.1385 1.092 1.1094 Profilin actin cytoskeleton;cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle actin binding;binding;cytoskeletal protein binding;protein binding actin cytoskeleton organization;actin filament-based process;cellular component organization;cellular process;cytoskeleton organization;organelle organization Regulation of actin cytoskeleton 13 13 13 88.6 88.6 88.6 15.054 0 19710000000 10268000000 9441100000 3310 IPI:IPI00216691.5;IPI:CON_00694107.2 Profilin-1;Profilin I PFN1 P07737 ENST00000225655 K05759 2 0.67588 1.3437 0.61169 0.88353 0.88624 0.82224 CH;Spectrin cytoskeleton;Golgi apparatus;intrinsic to internal side of plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;macromolecular complex;membrane-bounded organelle;nucleus;organelle;spectrin;spectrin-associated cytoskeleton actin binding;actin filament binding;binding;cytoskeletal protein binding;protein binding;structural constituent of cytoskeleton;structural molecule activity negative regulation of macromolecule metabolic process;negative regulation of metabolic process;negative regulation of organelle organization;regulation of actin polymerization or depolymerization;regulation of metabolic process 8 2 2 3.5 0.8 0.8 267.82 2.642E-43 253270000 142880000 110390000 3311 IPI:IPI00216704.9;IPI:IPI00783228.4;IPI:IPI00237806.6 Spectrin beta chain, erythrocyte;Beta-I spectrin SPTB;SPTB1 P11277-2;P11277;P11277-1;P11277-3 ENST00000389720;ENST00000389721;ENST00000389722;ENST00000389723 K06115 3 0.69788 1.4721 0.81955 0.9941 0.94336 1.1443 Histone cell part;chromosomal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;macromolecular complex;membrane-bounded organelle;nucleosome;nucleus;organelle;organelle part;protein-DNA complex binding;DNA binding;nucleic acid binding anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;chromatin organization;nucleosome assembly;organelle organization Systemic lupus erythematosus 4 2 1 57.7 28.5 10.8 13.995 1.8169E-126 908070000 334860000 573210000 3312 IPI:IPI00216730.3 Histone H2A type 2-B HIST2H2AB Q8IUE6 ENST00000331128 K11251 1 0.4589 0.77913 0.43744 0.62087 0.50089 0.57642 cobW;CobW_C adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding 4 4 4 13.4 13.4 13.4 44.068 1.999E-62 8750600 4727300 4023300 3313 IPI:IPI00305163.4;IPI:IPI00216734.2;IPI:IPI00645209.2;IPI:IPI00402055.2;IPI:IPI00472118.3;IPI:IPI00645737.1;IPI:IPI00748308.2;IPI:IPI00761134.2;IPI:IPI00930449.2;IPI:IPI00887061.1 COBW domain-containing protein 1;Cobalamin synthetase W domain-containing protein 1;NPC-A-6 COBW domain-containing protein 1;COBW domain-containing protein 2;Cobalamin synthetase W domain-containing protein 2;COBW domain-containing protein 3;Cobalamin synthetase W domain-containing protein 3;COBW domain-containing protein 5;Cobalamin synthetase W domain-containing protein 5;COBW domain-containing protein 6;Cobalamin synthetase W domain-containing protein 6 CBWD1;CBWD2;CBWD3;CBWD5;CBWD6 Q9BRT8-1;Q9BRT8;Q8IUF1;Q9BRT8-3;Q5JTY5;Q5RIA9-1;Q5RIA9;Q4V339;Q9BRT8-2;Q9BRT8-5;Q9BRT8-4 ENST00000356521;ENST00000382414;ENST00000382447;ENST00000259199;ENST00000360171;ENST00000314367;ENST00000377342;ENST00000377392;ENST00000377395;ENST00000382436;ENST00000377457 10 0.49719 0.89626 0.45531 0.65445 0.60274 0.60065 Cupin_4 cell part;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part cellular component biogenesis;cellular process;ribonucleoprotein complex biogenesis;ribosome biogenesis 7 7 7 17.6 17.6 17.6 52.8 2.0567E-80 129020000 71896000 57128000 3314 IPI:IPI00216737.3;IPI:IPI00395527.2;IPI:IPI00383332.2;IPI:IPI00868858.1 MYC-induced nuclear antigen;Mineral dust-induced gene protein;Nucleolar protein 52 MINA;MDIG;MINA53;NO52 Q8IUF8-1;Q8IUF8;Q8IUF8-4;Q8IUF8-2 ENST00000330299;ENST00000333396;ENST00000394198 4 0.70482 1.7183 0.63261 0.93056 1.1157 0.8593 RRM_1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;nucleotide binding;RNA binding anatomical structure development;cell differentiation;cellular developmental process;cellular process;developmental process;nervous system development;system development 2 2 2 4.2 4.2 4.2 53.502 1.2428E-06 16332000 9028200 7303900 3315 IPI:IPI00216750.1;IPI:IPI00789303.1;IPI:IPI00552178.2 RNA-binding protein 45;RNA-binding motif protein 45;Developmentally-regulated RNA-binding protein 1 RBM45;DRB1;DRBP1 Q8IUH3-1;Q8IUH3;Q8IUH3-3;Q8IUH3-2 ENST00000286070 3 NaN 0.89651 NaN NaN 0.63121 NaN TBC cell part;intracellular enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity;Rab GTPase activator activity;Ras GTPase activator activity;small GTPase regulator activity biological regulation;regulation of catalytic activity;regulation of GTPase activity;regulation of hydrolase activity;regulation of molecular function;regulation of Rab GTPase activity;regulation of Ras GTPase activity 2 2 2 7 7 7 49.712 9.042E-139 4619700 2660700 1959000 3316 IPI:IPI00216811.1 Carabin;TBC1 domain family member 10C TBC1D10C Q8IV04 ENST00000312390;ENST00000393906 1 NaN 1.3459 NaN NaN 0.88182 NaN Topoisom_bac;Toprim cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;DNA binding;DNA topoisomerase activity;DNA topoisomerase type I activity;isomerase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding cellular process;DNA geometric change;DNA metabolic process;DNA topological change;DNA unwinding during replication;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Homologous recombination 5 4 4 7 5.7 5.7 96.661 4.6589E-15 7420700 4256300 3164400 3317 IPI:IPI00292671.1;IPI:IPI00216815.1;IPI:IPI00216816.1 DNA topoisomerase 3-beta-1;DNA topoisomerase III beta-1 TOP3B;TOP3B1 O95985-1;O95985;O95985-2;O95985-3 ENST00000357179;ENST00000398789;ENST00000398793;ENST00000403680 K03165 3 0.91281 1.465 0.84003 1.2411 0.90147 1.1504 Ank;zf-MYND binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding 6 6 6 16.1 16.1 16.1 49.298 1.9446E-195 46876000 24762000 22114000 3318 IPI:IPI00216856.3 Ankyrin repeat and MYND domain-containing protein 2 ANKMY2 Q8IV38 ENST00000306999 1 0.571 1.2859 NaN 0.77414 0.81181 NaN Exonuc_X-T;SAP cell part;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part 3'-5' exonuclease activity;binding;catalytic activity;exonuclease activity;hydrolase activity;hydrolase activity, acting on ester bonds;magnesium ion binding;nuclease activity;nucleic acid binding;ribonucleoprotein binding;RNA binding;rRNA binding cellular process;metabolic process;negative regulation of metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of gene expression;RNA processing;rRNA processing 7 7 7 21.8 21.8 21.8 40.063 1.3536E-31 38803000 19843000 18959000 3319 IPI:IPI00216873.3 3'-5' exoribonuclease 1;Histone mRNA 3'-exonuclease 1;3'-5' exonuclease ERI1;Eri-1 homolog;Histone mRNA 3'-end-specific exoribonuclease;Protein 3'hExo ERI1;3'EXO;THEX1 Q8IV48 ENST00000250263 K01175 1 0.77328 1.5096 0.71449 0.9531 1.0386 0.95683 LysM catabolic process;cell wall macromolecule catabolic process;cell wall macromolecule metabolic process;macromolecule metabolic process;metabolic process 2 2 2 9.8 9.8 9.8 23.463 8.2796E-11 48495000 25270000 23226000 3320 IPI:IPI00216874.2 LysM and putative peptidoglycan-binding domain-containing protein 2 LYSMD2 Q8IV50-1;Q8IV50 ENST00000267838 1 0.82939 1.3779 0.92925 1.0395 0.97164 1.1421 AMP-binding cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part acetate-CoA ligase activity;acid-thiol ligase activity;AMP binding;ATP binding;binding;catalytic activity;CoA-ligase activity;ligase activity;ligase activity, forming carbon-sulfur bonds;nucleoside binding;nucleotide binding;purine nucleoside binding metabolic process Glycolysis / Gluconeogenesis;Propanoate metabolism;Pyruvate metabolism;Reductive carboxylate cycle (CO2 fixation) 14 14 14 21.6 21.6 21.6 74.856 6.5341E-116 314410000 181170000 133240000 3323 IPI:IPI00216932.4;IPI:IPI00248961.1 Acetyl-coenzyme A synthetase 2-like, mitochondrial;Acetate--CoA ligase 2;Acetyl-CoA synthetase 2;Acyl-CoA synthetase short-chain family member 1 ACSS1;ACAS2L;KIAA1846 Q9NUB1-1;Q9NUB1;Q9NUB1-2 ENST00000323482 K01895 2 0.77894 1.4026 0.80737 1.0147 0.98273 1.0104 tRNA_anti;tRNA-synt_2 cell fraction;cell part;cytoplasm;intracellular part;soluble fraction aminoacylase activity;aminoacyl-tRNA ligase activity;aspartate-tRNA ligase activity;ATP binding;binding;catalytic activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding aspartyl-tRNA aminoacylation;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;protein complex assembly;tRNA aminoacylation for protein translation;tRNA metabolic process Alanine and aspartate metabolism;Aminoacyl-tRNA biosynthesis 35 35 35 71.3 71.3 71.3 57.136 0 4710800000 2448500000 2262300000 3324 IPI:IPI00216951.2 Aspartyl-tRNA synthetase, cytoplasmic;Aspartate--tRNA ligase;Cell proliferation-inducing gene 40 protein DARS;PIG40 P14868 ENST00000264161 K01876 1 0.85042 1.3002 0.86809 1.0376 0.92941 1.0393 F_actin_bind;Pkinase_Tyr;SH2;SH3_1 cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part catalytic activity;DNA binding;magnesium ion binding;non-membrane spanning protein tyrosine kinase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein kinase activity;protein tyrosine kinase activity;purine nucleoside binding DNA metabolic process;DNA repair;mismatch repair;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription during S-phase of mitotic cell cycle;regulation of transcription, DNA-dependent Axon guidance;Cell cycle;Chronic myeloid leukemia;ErbB signaling pathway;Pathways in cancer 3 3 3 3 3 3 124.95 1.8029E-07 149070000 77738000 71331000 3325 IPI:IPI00221171.4;IPI:IPI00216969.3 Proto-oncogene tyrosine-protein kinase ABL1;Abelson murine leukemia viral oncogene homolog 1;c-ABL;p150 ABL1;ABL;JTK7 P00519-2;P00519;P00519-1 ENST00000318560;ENST00000372348 K06619 2 0.86527 1.5341 1.0254 1.0316 1.0528 1.3065 Ank;ArfGap;GIT_SHD cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part ARF GTPase activator activity;binding;cation binding;enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;ion binding;metal ion binding;protein binding;small GTPase regulator activity;zinc ion binding regulation of ARF GTPase activity;regulation of cell communication;regulation of G-protein coupled receptor protein signaling pathway;regulation of GTPase activity;regulation of Ras GTPase activity;regulation of signal transduction 9 6 1 16.5 12.5 1.3 84.542 1.6411E-40 69475000 37728000 31747000 3327 IPI:IPI00238218.3;IPI:IPI00216994.1;IPI:IPI00216997.1;IPI:IPI00216996.1;IPI:IPI00216991.1;IPI:IPI00216993.1;IPI:IPI00216998.3;IPI:IPI00413822.3;IPI:IPI00186690.6;IPI:IPI00376496.1 ARF GTPase-activating protein GIT2;G protein-coupled receptor kinase-interactor 2;GRK-interacting protein 2;Cool-interacting tyrosine-phosphorylated protein 2 GIT2;KIAA0148 Q14161-1;Q14161;Q14161-5;Q14161-8;Q14161-7;Q14161-3;Q14161-4;Q14161-9;Q14161-11;Q14161-2;Q14161-10 ENST00000320063;ENST00000338373;ENST00000343646;ENST00000354574;ENST00000355312;ENST00000356259;ENST00000360185;ENST00000361006 10 0.69282 1.5546 0.67211 0.9468 0.99585 0.87253 PUF cell part;cytoskeleton;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;RNA binding 6 6 6 11.8 11.8 11.8 69.437 8.115E-118 41168000 20960000 20208000 3328 IPI:IPI00216999.2 Pumilio domain-containing protein C14orf21 C14orf21;KIAA2021 Q86U38 ENST00000267425 1 1.9801 1.5282 0.86591 2.5319 0.9496 1.1354 DUF625 centrosome;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;microtubule organizing center;non-membrane-bounded organelle;nucleus;organelle;organelle part binding;protein binding 13 13 10 17.6 17.6 13.4 95.367 1.783E-148 124540000 66666000 57875000 3329 IPI:IPI00217013.2;IPI:IPI00479778.2;IPI:IPI00792955.1;IPI:IPI00384714.2;IPI:IPI00017290.4;IPI:IPI00793513.1 Serine/threonine-protein phosphatase 4 regulatory subunit 3A;SMEK homolog 1 SMEK1;KIAA2010;PP4R3A;PPP4R3A;MSTP033 Q6IN85-1;Q6IN85;Q6IN85-2;Q6IN85-3;Q6IN85-4;Q6IN85-5 ENST00000337238 6 0.51355 1.5368 NaN 0.65646 0.98895 NaN SAM_1 cell part;cytoplasm;intracellular part 8 8 8 6 6 6 184.28 1.2055E-55 6590500 3671500 2919000 3330 IPI:IPI00217018.2 Sterile alpha motif domain-containing protein 9 SAMD9;C7orf5;DRIF1;KIAA2004;OEF1 Q5K651 ENST00000379958 1 0.51138 1.4156 0.60329 0.71948 0.94782 0.77086 ArgK cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity 8 8 8 17.9 17.9 17.9 47.135 1.1422E-15 46882000 25813000 21069000 3331 IPI:IPI00217023.2 Methylmalonic aciduria type A protein, mitochondrial MMAA Q8IVH4 ENST00000281317 K07588 1 0.72541 1.3137 0.69099 0.93135 0.90088 0.89121 KOW;Ribosomal_S4e;RS4NT;S4 cell part;cytoplasmic part;cytosolic part;cytosolic small ribosomal subunit;intracellular organelle part;intracellular part;macromolecular complex;organelle part;polysome;ribonucleoprotein complex;ribosomal subunit;ribosome;small ribosomal subunit binding;nucleic acid binding;RNA binding;rRNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;macromolecule biosynthetic process;metabolic process;multicellular organismal development;positive regulation of cell proliferation;regulation of biosynthetic process;regulation of translation;translational elongation Ribosome 24 24 24 62 62 62 29.597 0 9145700000 4971700000 4173900000 3332 IPI:IPI00217030.10;IPI:IPI00219894.5;IPI:IPI00302740.8 40S ribosomal protein S4, X isoform;Single copy abundant mRNA protein;SCR10;40S ribosomal protein S4, Y isoform 2 RPS4X;CCG2;RPS4;SCAR;RPS4Y2;RPS4Y2P P62701;Q8TD47 ENST00000316084;ENST00000288666 K02987 3 0.52464 1.6261 0.53777 0.70055 1.0669 0.72555 NTP_transf_2;OAS1_C cell fraction;endoplasmic reticulum;insoluble fraction;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane fraction;membrane-bounded organelle;microsome;mitochondrion;nucleus;organelle;vesicular fraction ATP binding;binding;catalytic activity;nucleic acid binding;nucleoside binding;nucleotide binding;nucleotidyltransferase activity;purine nucleoside binding;RNA binding;transferase activity;transferase activity, transferring phosphorus-containing groups cellular metabolic process;cellular process;immune response;immune system process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;primary metabolic process;response to stimulus 5 5 5 7.1 7.1 7.1 82.43 1.259E-10 57671000 33543000 24128000 3333 IPI:IPI00217049.4;IPI:IPI00218185.3 2'-5'-oligoadenylate synthetase 2;p69 OAS / p71 OAS OAS2 P29728-1;P29728;P29728-2 ENST00000342315;ENST00000392583 2 0.96791 1.6591 0.842 1.191 1.0891 1.0451 DUF84 cell part;cytoplasmic part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle 6 6 6 19.4 19.4 19.4 48.525 3.0001E-231 98465000 51530000 46936000 3334 IPI:IPI00744319.2;IPI:IPI00217053.6;IPI:IPI00868973.1;IPI:IPI00868764.1;IPI:IPI00868717.1 Protein PPRC1 PRRC1 Q96M27-2;Q96M27;Q96M27-3;Q96M27-1;Q96M27-5;Q96M27-4 ENST00000296666;ENST00000330542 5 NaN 0.66269 0.088651 NaN 0.42351 0.10859 Pkinase;Pkinase_C cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation Acute myeloid leukemia;ErbB signaling pathway;Insulin signaling pathway;mTOR signaling pathway;TGF-beta signaling pathway 4 4 4 10.6 10.6 10.6 53.483 1.5274E-10 7334400 5190800 2143600 3335 IPI:IPI00217069.6 Ribosomal protein S6 kinase beta-2;70 kDa ribosomal protein S6 kinase 2;p70 ribosomal S6 kinase beta;S6 kinase-related kinase;Serine/threonine-protein kinase 14 beta RPS6KB2;STK14B Q9UBS0 ENST00000312629 K04688 1 0.53932 1.2061 0.71393 0.7177 0.82101 0.95346 MAGE cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle biological regulation;regulation of biological process;regulation of growth 6 6 6 12.5 12.5 12.5 34.308 9.2441E-21 48112000 27501000 20611000 3336 IPI:IPI00217104.4 Melanoma-associated antigen G1;MAGE-G1 antigen;Necdin-like protein 2;Hepatocellular carcinoma-associated protein 4 NDNL2;HCA4;MAGEG1 Q96MG7 ENST00000332303 1 0.96653 1.2047 0.78256 1.165 0.82484 1.067 Vac_ImportDeg 2 2 2 7 7 7 33.514 3.4065E-06 10111000 5636100 4474600 3337 IPI:IPI00217151.3 Uncharacterized protein C17orf39 C17orf39 Q8IVV7 ENST00000268719 1 0.69558 1.3689 0.6989 0.91755 0.89668 0.91552 AIRC;SAICAR_synt ATP binding;binding;catalytic activity;lyase activity;nucleoside binding;nucleotide binding;phosphoribosylaminoimidazole carboxylase activity;phosphoribosylaminoimidazolesuccinocarboxamide synthase activity;protein binding;purine nucleoside binding 'de novo' IMP biosynthetic process;IMP biosynthetic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;purine base metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process Purine metabolism 34 34 34 61.4 61.4 61.4 49.679 0 7959900000 4331400000 3628400000 3338 IPI:IPI00217223.1 Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;SAICAR synthetase;Phosphoribosylaminoimidazole carboxylase;AIR carboxylase PAICS;ADE2;AIRC;PAIS P22234 ENST00000264221 K01587 1 0.81843 1.6289 0.79674 1.089 1.0921 1.0232 ATP-grasp_2;Ligase_CoA cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle ATP binding;binding;catalytic activity;CoA-ligase activity;ligase activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;succinate-CoA ligase (ADP-forming) activity;succinate-CoA ligase activity acetyl-CoA metabolic process;coenzyme metabolic process;metabolic process;nitrogen compound metabolic process;porphyrin biosynthetic process;porphyrin metabolic process;succinyl-CoA metabolic process;succinyl-CoA pathway;tricarboxylic acid cycle Citrate cycle (TCA cycle);Propanoate metabolism 16 16 16 39.1 39.1 39.1 50.317 0 831940000 269570000 562370000 3339 IPI:IPI00464979.4;IPI:IPI00217232.2 Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial;ATP-specific succinyl-CoA synthetase subunit beta;Succinyl-CoA synthetase beta-A chain;Renal carcinoma antigen NY-REN-39 SUCLA2 Q9P2R7-1;Q9P2R7;Q9P2R7-2 ENST00000378654 K01900 2 0.78165 1.4035 0.83668 1.0022 0.9408 1.0717 TBCA cell part;cytoplasm;cytoskeletal part;intracellular organelle part;intracellular part;microtubule;organelle part binding;chaperone binding;protein binding;unfolded protein binding anatomical structure formation;cellular component organization;cellular process;metabolic process;post-chaperonin tubulin folding pathway;protein complex assembly;protein folding;protein metabolic process;tubulin complex assembly 10 10 10 55.6 55.6 55.6 12.855 2.7575E-220 4864400000 2476900000 2387500000 3340 IPI:IPI00217236.4 Tubulin-specific chaperone A;Tubulin-folding cofactor A;TCP1-chaperonin cofactor A TBCA O75347 ENST00000306388;ENST00000380377 1 0.42302 0.88031 0.39154 0.55331 0.59902 0.5076 WD40 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part 12 12 12 19.4 19.4 19.4 94.498 9.6017E-101 212750000 125120000 87629000 3341 IPI:IPI00217240.1 WD repeat-containing protein 75 WDR75 Q8IWA0 ENST00000314761 1 0.7267 NaN 0.6839 0.97859 NaN 0.91023 DUF2404 cell part;integral to membrane;intrinsic to membrane;membrane part cell communication;cellular lipid metabolic process;cellular metabolic process;cellular process;lipid metabolic process;membrane lipid metabolic process;metabolic process;primary metabolic process;signal transduction;sphingolipid metabolic process 4 4 4 3.4 3.4 3.4 126 9.3031E-18 5839600 3324800 2514800 3342 IPI:IPI00217261.3;IPI:IPI00761041.1 Testis-expressed sequence 2 protein TEX2;KIAA1738 Q8IWB9-2;Q8IWB9;Q8IWB9-1 ENST00000258991 2 0.78751 1.5853 0.75927 1.0248 1.058 1.0101 AMP-binding cell part;cytoplasmic part;cytosol;intracellular part acid-thiol ligase activity;adenyl nucleotide binding;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-sulfur bonds;nucleoside binding;nucleotide binding;purine nucleoside binding;purine nucleotide binding carboxylic acid metabolic process;cellular ketone metabolic process;cellular process;fatty acid metabolic process;lipid metabolic process;metabolic process;monocarboxylic acid metabolic process;organic acid metabolic process;oxoacid metabolic process Butanoate metabolism 5 5 4 6.1 6.1 5.2 75.143 2.0614E-09 37113000 19974000 17139000 3343 IPI:IPI00217272.7;IPI:IPI00646775.2;IPI:IPI00789348.1 Acetoacetyl-CoA synthetase;Acyl-CoA synthetase family member 1;Protein sur-5 homolog AACS;ACSF1 Q86V21-1;Q86V21;Q86V21-2 ENST00000261686;ENST00000316519 K01907 3 0.65177 1.7289 NaN 0.88937 1.1339 NaN zf-CCCH cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding 6 6 5 7.2 7.2 5.6 110.54 1.5236E-16 14443000 7793100 6650200 3344 IPI:IPI00217355.1;IPI:IPI00607547.1 Zinc finger CCCH domain-containing protein 7A ZC3H7A;ZC3H7;ZC3HDC7;HSPC055 Q8IWR0-1;Q8IWR0;Q8IWR0-2 ENST00000355758;ENST00000396516 2 0.84344 1.858 0.96475 1.1418 1.2169 1.2997 SAP cell part;cytoplasmic part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle;perinuclear region of cytoplasm binding;nucleic acid binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 12 12 12 11.3 11.3 11.3 132.82 3.2883E-85 220850000 117340000 103510000 3345 IPI:IPI00217357.2;IPI:IPI00939119.1 Cell division cycle and apoptosis regulator protein 1;Cell cycle and apoptosis regulatory protein 1;Death inducer with SAP domain CCAR1;CARP1;DIS Q8IX12-1;Q8IX12;Q8IX12-2 ENST00000265872 2 0.87119 1.3763 0.78213 1.1255 0.92452 1.0263 CGI-121 cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;enzyme binding;kinase binding;protein binding;protein kinase binding biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process 6 6 6 37.4 37.4 37.4 23.854 8.2477E-99 131690000 72609000 59080000 3346 IPI:IPI00217362.2;IPI:IPI00301432.3;IPI:IPI00829935.1 TP53RK-binding protein;PRPK-binding protein TPRKB;CGI-121;My019 Q9Y3C4-3;Q9Y3C4;Q9Y3C4-1;Q9Y3C4-2 ENST00000272424;ENST00000318190;ENST00000406407;ENST00000409716 3 NaN 1.9825 NaN NaN 1.4278 NaN Ank;ArfGap;Miro;PH cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ARF GTPase activator activity;binding;catalytic activity;enzyme activator activity;GTP binding;GTPase activator activity;GTPase activity;hydrolase activity;nucleotide binding;pyrophosphatase activity;small GTPase regulator activity;zinc ion binding cell communication;cellular process;intracellular signaling cascade;protein transport;regulation of ARF GTPase activity;regulation of GTPase activity;regulation of Ras GTPase activity;signal transduction;small GTPase mediated signal transduction;transport 6 1 1 7.2 0.7 0.7 124.67 9.5168E-138 322350000 164990000 157350000 3347 IPI:IPI00217393.1 Arf-GAP, GTPase, ANK repeat and PH domain-containing protein 2;Centaurin-gamma-1;Phosphatidylinositol-3-kinase enhancer;GTP-binding and GTPase-activating protein 2 AGAP2;CENTG1;KIAA0167 Q99490-1;Q99490 ENST00000257897;ENST00000328568 1 0.59627 1.1152 0.87417 0.7775 0.75999 1.1065 ClpS;zf-UBR cell part;cytoplasmic part;cytosol;intracellular part binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding 11 11 11 8.6 8.6 8.6 200.21 2.4816E-233 36492000 19512000 16980000 3348 IPI:IPI00217405.1;IPI:IPI00470915.2 E3 ubiquitin-protein ligase UBR1;N-recognin-1;Ubiquitin-protein ligase E3-alpha-1;Ubiquitin-protein ligase E3-alpha-I UBR1 Q8IWV7-1;Q8IWV7 ENST00000290650;ENST00000382177 K10625 2 0.8136 1.5863 0.82515 1.081 0.98601 1.1071 ClpS;zf-UBR cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding 16 16 16 11.5 11.5 11.5 200.54 4.0059E-75 109410000 59604000 49807000 3349 IPI:IPI00217407.2;IPI:IPI00640085.1;IPI:IPI00640329.1;IPI:IPI00445539.2 E3 ubiquitin-protein ligase UBR2;N-recognin-2;Ubiquitin-protein ligase E3-alpha-2;Ubiquitin-protein ligase E3-alpha-II UBR2;C6orf133;KIAA0349 Q8IWV8-4;Q8IWV8;Q8IWV8-1 ENST00000372883;ENST00000372899;ENST00000372901 K10626 4 0.72053 1.3329 0.71632 0.9064 0.85211 0.89216 DEAD;DUF1605;HA2;Helicase_C cell part;cytoplasm;intracellular part ATP binding;ATP-dependent helicase activity;binding;catalytic activity;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;translation initiation factor activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 6 6 6 4.8 4.8 4.8 155.23 1.7275E-22 48018000 26096000 21921000 3350 IPI:IPI00217413.3;IPI:IPI00168885.5 ATP-dependent RNA helicase DHX29;DEAH box protein 29;Nucleic acid helicase DDXx DHX29;DDX29 Q7Z478 ENST00000251636 2 0.61939 1.3601 0.66848 0.88501 0.80876 0.91035 Linker_histone cell part;chromosomal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;macromolecular complex;membrane-bounded organelle;nucleosome;nucleus;organelle;organelle part;protein-DNA complex binding;DNA binding;nucleic acid binding anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;chromatin organization;nucleosome assembly;organelle organization 10 3 3 28.6 9.9 9.9 21.364 4.3088E-259 1511200000 957020000 554200000 3351 IPI:IPI00217465.5;IPI:IPI00419983.3;IPI:IPI00217469.3 Histone H1.2;Histone H1d HIST1H1C;H1F2 P16403 ENST00000343677 K11275 3 0.51546 NaN 0.66205 0.7605 NaN 0.82991 Linker_histone cell part;chromosomal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;macromolecular complex;membrane-bounded organelle;nucleosome;nucleus;organelle;organelle part;protein-DNA complex binding;DNA binding;nucleic acid binding anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;chromatin organization;nucleosome assembly;organelle organization 9 2 2 27.1 9 9 22.35 6.8199E-176 192550000 107920000 84629000 3352 IPI:IPI00217466.3 Histone H1.3;Histone H1c HIST1H1D;H1F3 P16402 ENST00000244534 K11275 1 0.6725 1.3322 0.78686 0.89679 0.87577 1.0506 Linker_histone cell part;chromosomal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;macromolecular complex;membrane-bounded organelle;nucleosome;nucleus;organelle;organelle part;protein-DNA complex binding;DNA binding;nucleic acid binding;protein binding anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;chromatin organization;nucleosome assembly;organelle organization 10 10 3 27.9 27.9 9.6 21.865 1.1165E-277 17083000000 9165400000 7917700000 3353 IPI:IPI00217467.3 Histone H1.4;Histone H1b HIST1H1E;H1F4 P10412 ENST00000304218 K11275 1 0.64996 1.4495 0.75532 0.8653 0.94776 0.99531 Linker_histone cell part;chromosomal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;macromolecular complex;membrane-bounded organelle;nucleosome;nucleus;organelle;organelle part;protein-DNA complex binding;DNA binding;nucleic acid binding anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;chromatin organization;nucleosome assembly;organelle organization 8 8 8 24.8 24.8 24.8 22.58 9.4518E-172 13245000000 7257500000 5987600000 3354 IPI:IPI00217468.3 Histone H1.5;Histone H1a HIST1H1B;H1F5 P16401 ENST00000331442 K11275 1 NaN 1.2231 0.60077 NaN 0.79505 0.86284 Ets;SAM_PNT cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;protein binding;sequence-specific DNA binding;transcription factor activity;transcription regulator activity biosynthetic process;hemostasis;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 3 3 3 8.8 8.8 8.8 50.981 0.00032658 25542000 13244000 12298000 3355 IPI:IPI00329755.7;IPI:IPI00217470.1 Friend leukemia integration 1 transcription factor;Fli-1 proto-oncogene;ERGB transcription factor FLI1 Q01543-1;Q01543;Q01543-2 ENST00000281428;ENST00000344954 K09436 2 0.71312 1.7101 0.75463 0.96439 1.0811 0.98671 HMG_box cell part;chromosome;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle binding;DNA bending activity;DNA binding;nucleic acid binding developmental process;multicellular organismal development;multicellular organismal process 10 10 10 31.5 31.5 31.5 22.98 7.1691E-79 338770000 184830000 153940000 3356 IPI:IPI00217477.5;IPI:IPI00006437.2;IPI:IPI00888935.1 High mobility group protein B3;High mobility group protein 4;High mobility group protein 2a;High mobility group protein B3-like-1;High-mobility group protein 4-like HMGB3;HMG2A;HMG4;HMGB3L1;HMG4L O15347;Q3SYE8 ENST00000325307 K11296 3 NaN 1.4954 0.7302 NaN 0.96627 1.0013 EST1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;enzyme binding;phosphatase binding;protein binding;protein phosphatase 2A binding;protein phosphatase binding mRNA catabolic process;nuclear-transcribed mRNA catabolic process;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA catabolic process;RNA export from nucleus 3 3 3 2.9 2.9 2.9 131.65 3.3689E-19 10997000 6106900 4889700 3358 IPI:IPI00657821.1;IPI:IPI00217494.2;IPI:IPI00448672.2;IPI:IPI00383508.2 Protein SMG7;SMG-7 homolog;EST1-like protein C SMG7;C1orf16;EST1C;KIAA0250 Q92540-4;Q92540;Q92540-1;Q92540-2;Q92540-3 ENST00000347615;ENST00000367539;ENST00000392015 4 0.89027 1.8151 0.96212 1.1866 1.1762 1.2626 Ras cell part;intracellular;membrane;plasma membrane binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;protein binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding behavior;cell communication;chemotaxis;cytoskeleton organization;intracellular signaling cascade;locomotory behavior;organelle organization;Ras protein signal transduction;signal transduction;small GTPase mediated signal transduction Pancreatic cancer;Pathways in cancer 5 5 5 23.8 23.8 23.8 23.567 1.9684E-106 346050000 179580000 166470000 3359 IPI:IPI00217519.3;IPI:IPI00927371.1 Ras-related protein Ral-A RALA;RAL P11233 ENST00000005257 K07834 2 0.74849 1.4891 0.85224 0.97756 0.98973 1.0881 EF_assoc_1;EF_assoc_2;Miro integral to membrane;integral to mitochondrial membrane;integral to mitochondrial outer membrane;integral to organelle membrane;intrinsic to membrane;intrinsic to mitochondrial outer membrane;intrinsic to organelle membrane;organelle part binding;calcium ion binding;catalytic activity;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;hydrolase activity;nucleotide binding;protein binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding apoptosis;cell communication;cell death;cellular process;intracellular signaling cascade;microtubule-based movement;microtubule-based process;microtubule-based transport;signal transduction;small GTPase mediated signal transduction;transport 8 8 7 11.1 11.1 9.6 79.547 2.9387E-35 154020000 80058000 73963000 3360 IPI:IPI00217536.3;IPI:IPI00651681.1;IPI:IPI00759714.1;IPI:IPI00432452.3;IPI:IPI00759775.1;IPI:IPI00759627.1;IPI:IPI00759537.1 Mitochondrial Rho GTPase 1;Ras homolog gene family member T1;Rac-GTP-binding protein-like protein RHOT1;ARHT1 Q8IXI2-3;Q8IXI2;Q8IXI2-5;Q8IXI2-2;Q8IXI2-1;Q8IXI2-4 ENST00000333942;ENST00000354266;ENST00000358365;ENST00000378607;ENST00000394692 K07870 7 0.39703 0.77994 0.39871 0.50058 0.56003 0.51048 DEAD;Helicase_C cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part ATP binding;ATP-dependent helicase activity;binding;catalytic activity;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity;RNA binding cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing Folate biosynthesis 12 12 12 22.5 22.5 22.5 72.456 9.3161E-188 109230000 62411000 46815000 3361 IPI:IPI00217541.3 ATP-dependent RNA helicase DDX51;DEAD box protein 51 DDX51 Q8N8A6 ENST00000397333 K01529 1 0.69322 1.5216 0.75387 0.86603 0.98551 0.96576 MRP-L27 cytoplasmic part;intracellular part;large ribosomal subunit;macromolecular complex;mitochondrial large ribosomal subunit;mitochondrial part;organellar large ribosomal subunit;organelle part;ribonucleoprotein complex;ribosomal subunit structural constituent of ribosome;structural molecule activity apoptosis;biosynthetic process;cell cycle;cell death;cellular macromolecule biosynthetic process;cellular process;death;macromolecule biosynthetic process;metabolic process;programmed cell death;protein metabolic process;translation 3 3 3 19.7 19.7 19.7 15.383 4.026E-08 90987000 47801000 43186000 3363 IPI:IPI00217553.1 39S ribosomal protein L41, mitochondrial;39S ribosomal protein L27 homolog;MRP-L27 homolog;Bcl-2-interacting mitochondrial ribosomal protein L41;Cell proliferation-inducing gene 3 protein MRPL41;BMRP;MRPL27;RPML27;PIG3 Q8IXM3 ENST00000371443 1 0.61199 1.3276 0.64087 0.77106 0.94602 0.7965 cell part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;nuclear inner membrane;nuclear membrane;nuclear part;organelle inner membrane;organelle membrane;organelle part 4 4 4 17.2 17.2 17.2 29.379 5.2751E-09 29693000 16612000 13081000 3364 IPI:IPI00217557.1;IPI:IPI00645046.1 Nurim;Nuclear rim protein;Nuclear envelope membrane protein NRM;NRM29;UNQ555/PRO1112 Q8IXM6-1;Q8IXM6;Q8IXM6-2 ENST00000259953;ENST00000376416;ENST00000376418;ENST00000376420;ENST00000376421;ENST00000383398;ENST00000383571 2 0.34806 0.92085 0.64068 0.46744 0.5971 0.87337 Hira;HIRA_B;WD40 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;chromatin binding;DNA binding;nucleic acid binding;protein binding;transcription cofactor activity;transcription corepressor activity;transcription factor activity;transcription factor binding;transcription repressor activity chromatin organization;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 6 6 6 8.6 8.6 8.6 111.83 2.1284E-28 35262000 19985000 15277000 3365 IPI:IPI00217560.3;IPI:IPI00218434.2 Protein HIRA;TUP1-like enhancer of split protein 1 HIRA;DGCR1;HIR;TUPLE1 P54198-1;P54198;P54198-2 ENST00000263208;ENST00000340170 K11293 2 0.92576 1.7538 0.97208 1.2861 1.1243 1.3461 EGF_2;Integrin_b_cyt;Integrin_B_tail;Integrin_beta cell projection;cell surface;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;integrin complex;macromolecular complex;melanosome;membrane;membrane-bounded vesicle;neuromuscular junction;organelle;plasma membrane;ruffle;sarcolemma;vesicle binding;identical protein binding;molecular transducer activity;protein binding;protein dimerization activity;protein heterodimerization activity;receptor activity;signal transducer activity cell activation;cell adhesion;cell communication;cell-matrix adhesion;cellular defense response;defense response;homophilic cell adhesion;immune system process;leukocyte adhesion;leukocyte differentiation;response to stress;signal transduction 12 12 12 18.5 18.5 18.5 88.414 2.5169E-67 176480000 89267000 87213000 3366 IPI:IPI00217563.4;IPI:IPI00217561.2;IPI:IPI00217562.5;IPI:IPI00549336.2;IPI:IPI00293305.4 Integrin beta-1;Fibronectin receptor subunit beta;Integrin VLA-4 subunit beta ITGB1;FNRB;MDF2;MSK12 P05556-1;P05556;P05556-3;P05556-4;P05556-5;P05556-2 ENST00000302252;ENST00000302278;ENST00000359614;ENST00000374956;ENST00000396033;ENST00000401956 5 0.5445 1.0455 0.4174 0.68769 0.71816 0.55368 cNMP_binding;Patatin cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part carboxylesterase activity;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;lipase activity;lysophospholipase activity;phospholipase activity alcohol metabolic process;biogenic amine metabolic process;cellular amino acid and derivative metabolic process;cellular amino acid derivative metabolic process;glycerophospholipid metabolic process;lipid metabolic process;phospholipid metabolic process 6 6 6 6.4 6.4 6.4 150.95 1.6163E-189 26189000 14403000 11786000 3367 IPI:IPI00640818.3;IPI:IPI00940388.1;IPI:IPI00217600.6 Neuropathy target esterase;Patatin-like phospholipase domain-containing protein 6 PNPLA6;NTE Q8IY17-1;Q8IY17;Q8IY17-3;Q8IY17-2 ENST00000221249 K07001 3 0.64633 NaN NaN 0.9817 NaN NaN CH;LIM cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding 2 1 1 3.2 2 2 97.501 5.2981E-10 12720000 7163900 5555800 3368 IPI:IPI00217622.1;IPI:IPI00003057.2;IPI:IPI00410370.1 MICAL-like protein 2 MICALL2 Q8IY33-1;Q8IY33;Q8IY33-5;Q8IY33-3 ENST00000297508;ENST00000405088 3 0.90666 1.2898 0.98177 1.2085 0.82308 1.3167 WD40 2 2 2 2.4 2.4 2.4 102.04 0.00089042 2542300 1414600 1127700 3369 IPI:IPI00645640.1;IPI:IPI00217629.3;IPI:IPI00479795.2 WD repeat-containing protein 47 WDR47;KIAA0893 O94967-3;O94967;O94967-1;O94967-2 ENST00000357672;ENST00000369962;ENST00000407372 3 0.38288 0.83272 0.38865 0.50878 0.59214 0.46998 DUF1605;HA2;Helicase_C ATP binding;binding;catalytic activity;helicase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity 7 7 7 7.7 7.7 7.7 129.54 7.9512E-63 30717000 18491000 12225000 3370 IPI:IPI00217630.1 Probable ATP-dependent RNA helicase DHX37;DEAH box protein 37 DHX37;DDX37;KIAA1517 Q8IY37 ENST00000308736 1 0.60225 1.5552 0.83267 0.8926 0.92741 1.1026 Glyco_transf_8 cell part;integral to membrane;intrinsic to membrane;membrane part catalytic activity;transferase activity;transferase activity, transferring glycosyl groups 2 2 2 4.5 4.5 4.5 50.566 0.0060123 9604800 5330500 4274300 3371 IPI:IPI00217652.5;IPI:IPI00791310.3 Glycosyltransferase 8 domain-containing protein 3 GLT8D3 Q4G148-1;Q4G148;Q4G148-2 ENST00000280876;ENST00000398675 2 0.8847 1.4481 0.83554 1.2112 0.92398 1.0891 MOZ_SAS cell part;chromatin;chromosomal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;nucleus;organelle;organelle part acyltransferase activity;binding;catalytic activity;chromatin binding;histone acetyltransferase activity;lysine N-acetyltransferase activity;N-acetyltransferase activity;protein binding;transcription factor binding;zinc ion binding chromatin assembly or disassembly;chromatin organization;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein amino acid acetylation;protein modification process;regulation of transcription, DNA-dependent;transcription 4 3 3 9.2 6.9 6.9 53.103 1.1508E-29 48696000 23475000 25221000 3372 IPI:IPI00217660.3;IPI:IPI00550352.2;IPI:IPI00103685.3 Probable histone acetyltransferase MYST1;MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1 MYST1;MOF;PP7073 Q9H7Z6-2;Q9H7Z6;Q9H7Z6-1;Q9H7Z6-3 ENST00000219797 K11308 3 0.76224 1.3006 0.7483 0.97352 0.91407 0.99022 RRM_1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding 14 14 14 34.1 34.1 34.1 79.578 1.952E-160 441720000 233070000 208660000 3373 IPI:IPI00217661.4;IPI:IPI00217670.1;IPI:IPI00643760.2 Ribonucleoprotein PTB-binding 1;Protein raver-1 RAVER1;KIAA1978 Q8IY67-2;Q8IY67;Q8IY67-1 ENST00000293677;ENST00000331131 3 NaN 1.2125 4.8265 NaN 0.85294 6.5064 BRCT;DNA_ligase_A_C;DNA_ligase_A_M;DNA_ligase_A_N adherens junction;cell junction;cell-substrate adherens junction;cell-substrate junction;chromosome;condensed chromosome;cytoplasm;DNA ligase IV complex;DNA-dependent protein kinase-DNA ligase 4 complex;focal adhesion;macromolecular complex;organelle ATP binding;binding;catalytic activity;DNA binding;DNA ligase (ATP) activity;DNA ligase activity;magnesium ion binding;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;protein C-terminus binding;purine nucleoside binding cell activation;in utero embryonic development;non-recombinational repair;single strand break repair;somatic diversification of immune receptors;somatic recombination of immunoglobulin genes during immune response Non-homologous end-joining 4 4 4 6.7 6.7 6.7 103.97 7.8069E-23 17345000 5685800 11660000 3374 IPI:IPI00217669.1 DNA ligase 4;DNA ligase IV;Polydeoxyribonucleotide synthase [ATP] 4 LIG4 P49917 ENST00000356922;ENST00000405925 K10777 1 0.63997 1.2668 0.6524 0.85466 0.81024 0.93033 FtsJ;Spb1_C cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;catalytic activity;methyltransferase activity;nucleic acid binding;transferase activity;transferase activity, transferring one-carbon groups cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;one-carbon metabolic process;RNA methylation;RNA modification;RNA processing;rRNA modification;rRNA processing 17 17 17 20.1 20.1 20.1 96.574 0 710140000 380640000 329500000 3375 IPI:IPI00217686.3 Putative rRNA methyltransferase 3;rRNA (uridine-2'-O-)-methyltransferase 3 FTSJ3;SB92 Q8IY81 ENST00000336599 1 0.67325 1.4772 NaN 0.86102 0.99085 NaN Frataxin_Cyay cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part binding;cation binding;ferric iron binding;ferrous iron binding;ion binding;iron chaperone activity;iron ion binding;iron-sulfur cluster binding;metal ion binding;metallochaperone activity;protein binding;transition metal ion binding cellular ion homeostasis;cellular iron ion homeostasis;heme biosynthetic process;metabolic process;nitrogen compound metabolic process;porphyrin biosynthetic process;porphyrin metabolic process;protein modification process;regulation of cell growth 2 2 2 13.8 13.8 13.8 23.135 3.4787E-26 19460000 10144000 9316600 3376 IPI:IPI00293425.1;IPI:IPI00217745.1 Frataxin, mitochondrial;Friedreich ataxia protein;Frataxin intermediate form;Frataxin(56-210);Frataxin(81-210) FXN;FRDA;X25 Q16595-1;Q16595;Q16595-2 ENST00000377270;ENST00000396364 2 1.0636 2.1523 0.99176 1.3386 1.4396 1.3578 CD36 cell fraction;insoluble fraction;integral to membrane;integral to plasma membrane;intracellular part;intrinsic to membrane;intrinsic to plasma membrane;lysosomal membrane;membrane;membrane fraction;organelle membrane;organelle part;vacuolar membrane binding;molecular transducer activity;protein binding;receptor activity;signal transducer activity biological adhesion;cell adhesion;cellular process 3 3 3 4.8 4.8 4.8 54.29 2.5996E-08 39896000 20523000 19373000 3377 IPI:IPI00217766.3 Lysosome membrane protein 2;Lysosome membrane protein II;LIMP II;Scavenger receptor class B member 2;85 kDa lysosomal membrane sialoglycoprotein;LGP85;CD36 antigen-like 2 SCARB2;CD36L2;LIMPII Q14108 ENST00000264896 K12384 1 NaN 1.4859 0.88181 NaN 0.95091 1.1418 Ank;UIM 2 2 2 5.1 5.1 5.1 67.618 1.45E-50 1099400 634200 465240 3380 IPI:IPI00217831.4 Ankyrin repeat domain-containing protein 13A;Protein KE03 ANKRD13A;ANKRD13 Q8IZ07 ENST00000261739 1 NaN NaN 0.89661 NaN NaN 1.1282 RPEL actin binding;binding;cytoskeletal protein binding;enzyme inhibitor activity;phosphatase inhibitor activity;phosphatase regulator activity;phosphoprotein phosphatase inhibitor activity;protein binding;protein phosphatase regulator activity 2 2 2 4.8 4.8 4.8 79.128 8.4675E-20 35579000 16878000 18702000 3381 IPI:IPI00657967.2;IPI:IPI00217851.6;IPI:IPI00845221.1;IPI:IPI00432436.2;IPI:IPI00845279.1 Phosphatase and actin regulator 4 PHACTR4;PRO2963 Q8IZ21-2;Q8IZ21;Q8IZ21-1;Q8IZ21-3;Q8IZ21-4;Q8IZ21-5 ENST00000373835;ENST00000373836;ENST00000373838;ENST00000373839 5 0.67547 1.223 0.64234 0.87836 0.78922 0.81529 M20_dimer;Peptidase_M20 binding;catalytic activity;hydrolase activity;metallopeptidase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides;protein binding;protein dimerization activity biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis 8 8 8 21.6 21.6 21.6 47.776 4.6137E-52 272980000 147700000 125280000 3382 IPI:IPI00217852.6 Peptidase M20 domain-containing protein 2;Aminoacylase 1-like protein 2 PM20D2;ACY1L2 Q8IYS1 ENST00000275072 1 0.49092 1.0461 0.52101 0.61527 0.73466 0.63491 WD40 intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nucleolus;organelle;ribonucleoprotein complex;small nuclear ribonucleoprotein complex;small nucleolar ribonucleoprotein complex binding;nucleic acid binding;RNA binding cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 11 11 11 30.7 30.7 30.7 51.84 1.5768E-150 436970000 244530000 192440000 3383 IPI:IPI00217862.5 U3 small nucleolar RNA-interacting protein 2;U3 small nucleolar ribonucleoprotein-associated 55 kDa protein;RRP9 homolog RRP9;RNU3IP2;U355K O43818 ENST00000232888 1 0.81231 2.0069 NaN 1.1074 1.3303 NaN Aldedh cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part 1-pyrroline-5-carboxylate dehydrogenase activity;aldehyde dehydrogenase (NAD) activity;catalytic activity;electron carrier activity;oxidoreductase activity;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;nitrogen compound metabolic process;organic acid metabolic process;proline biosynthetic process;proline catabolic process;proline metabolic process Arginine and proline metabolism;Glutamate metabolism 3 3 3 6.4 6.4 6.4 61.719 3.5286E-07 21144000 11578000 9565400 3384 IPI:IPI00217871.4 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial;Aldehyde dehydrogenase family 4 member A1 ALDH4A1;ALDH4;P5CDH P30038 ENST00000290597;ENST00000375341 K00294 1 NaN 1.4025 NaN NaN 0.87952 NaN cell fraction;cell surface;coated pit;early endosome;endoplasmic reticulum membrane;endosome;endosome membrane;Golgi membrane;insoluble fraction;integral to membrane;lysosomal membrane;membrane;membrane fraction;microsome;vacuolar membrane binding;enzyme binding;growth factor binding;nerve growth factor receptor activity;neurotrophin receptor activity;protein binding;receptor activity;signal transducer activity;transmembrane receptor activity cell communication;endocytosis;Golgi to endosome transport;induction of apoptosis;intracellular protein transport;lysosomal transport;organelle organization;ossification;post-Golgi vesicle-mediated transport;transport;vacuolar transport 3 3 3 4.1 4.1 4.1 92.067 4.0143E-14 12453000 904200 11549000 3385 IPI:IPI00217882.3 Sortilin;Neurotensin receptor 3;Glycoprotein 95;100 kDa NT receptor SORT1 Q99523 ENST00000256637 K12388 1 0.59794 1.6944 0.60262 0.73957 1.1746 0.91056 zf-C3HC4 chromosome;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle;ubiquitin ligase complex acid-amino acid ligase activity;binding;catalytic activity;chromatin binding;ligase activity;ligase activity, forming carbon-nitrogen bonds;protein binding;small conjugating protein ligase activity;ubiquitin-protein ligase activity;zinc ion binding chromatin organization;DNA metabolic process;DNA repair;double-strand break repair;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein modification process;proteolysis;regulation of DNA repair 3 3 3 7.4 7.4 7.4 65.019 2.7388E-07 2392500 1388200 1004200 3386 IPI:IPI00217899.1 E3 ubiquitin-protein ligase RNF168;RING finger protein 168 RNF168 Q8IYW5 ENST00000318037 1 0.62653 1.3519 0.5685 0.84057 0.88644 0.69635 ELMO_CED12 cell part;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle cellular component organization;cellular process;endocytosis;establishment of localization;membrane invagination;membrane organization;phagocytosis;transport;vesicle-mediated transport 4 4 4 13.3 13.3 13.3 34.96 6.3247E-58 40844000 31822000 9021800 3387 IPI:IPI00217918.1 ELMO domain-containing protein 2 ELMOD2 Q8IZ81 ENST00000323570 1 0.51105 1.0398 0.59341 0.66782 0.73995 0.72914 Aldedh binding;catalytic activity;oxidoreductase activity;protein binding metabolic process 9 9 9 15.7 15.7 15.7 85.126 2.1006E-61 181490000 104400000 77099000 3388 IPI:IPI00217920.7;IPI:IPI00646424.3 Aldehyde dehydrogenase family 16 member A1 ALDH16A1 Q8IZ83-1;Q8IZ83 ENST00000293350 2 0.9178 1.6238 0.87078 1.1667 1.1722 1.0519 UQ_con acid-amino acid ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleoside binding;nucleotide binding;purine nucleoside binding;ubiquitin-protein ligase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein metabolic process;protein modification process;proteolysis;regulation of metabolic process Ubiquitin mediated proteolysis 8 8 8 51.8 51.8 51.8 23.845 2.5617E-154 632800000 331740000 301060000 3389 IPI:IPI00217949.12 Ubiquitin-conjugating enzyme E2 S;Ubiquitin-protein ligase S;Ubiquitin carrier protein S;Ubiquitin-conjugating enzyme E2-24 kDa;E2-EPF5 UBE2S;E2EPF;OK/SW-cl.73 Q16763 ENST00000264552 K10583 1 NaN NaN 0.77564 NaN NaN 1.2847 HMG14_17 cell part;chromatin;chromosomal part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;nucleus;organelle;organelle part binding;DNA binding;hormone receptor binding;nuclear hormone receptor binding;nucleic acid binding;protein binding;receptor binding;thyroid hormone receptor binding;transcription factor binding cellular component organization;cellular process;chromatin organization;organelle organization;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of transcription, DNA-dependent 2 2 2 43.3 43.3 43.3 9.3926 7.5452E-10 14933000 7901400 7031200 3390 IPI:IPI00217950.5;IPI:IPI00018842.2;IPI:IPI00171277.3 Non-histone chromosomal protein HMG-17;High-mobility group nucleosome-binding domain-containing protein 2;High mobility group nucleosome-binding domain-containing protein 3;Thyroid receptor-interacting protein 7 HMGN2;HMG17;HMGN3;TRIP7;PNAS-24 P05204;Q15651-1;Q15651;Q15651-2 ENST00000361427;ENST00000275036;ENST00000344726 K11300;K11301 3 0.84298 1.6226 0.88404 1.0961 1.0439 1.1553 GATase_2;SIS cell part;cytoplasm;intracellular part binding;carbohydrate binding;catalytic activity;glutamine-fructose-6-phosphate transaminase (isomerizing) activity;sugar binding;transaminase activity;transferase activity;transferase activity, transferring nitrogenous groups alcohol metabolic process;carbohydrate metabolic process;fructose 6-phosphate metabolic process;fructose metabolic process;generation of precursor metabolites and energy;monosaccharide metabolic process;organic acid metabolic process 27 27 22 49.4 49.4 39.8 78.806 0 1559300000 810300000 749050000 3391 IPI:IPI00217952.6;IPI:IPI00299506.9 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1;Glutamine:fructose 6 phosphate amidotransferase 1;D-fructose-6-phosphate amidotransferase 1;Hexosephosphate aminotransferase 1 GFPT1;GFAT;GFPT Q06210-1;Q06210;Q06210-2 ENST00000357308;ENST00000361060 2 0.64605 1.3033 0.67628 0.88723 0.85666 0.89453 Ldh_1_C;Ldh_1_N cell part;cytoplasmic part;cytosol;intracellular part binding;catalytic activity;lactate dehydrogenase activity;L-lactate dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;protein binding alcohol metabolic process;carbohydrate metabolic process;catabolic process;cellular process;generation of precursor metabolites and energy;glucose catabolic process;glucose metabolic process;glycolysis;metabolic process;monosaccharide metabolic process 33 33 29 77.7 77.7 69.6 36.688 0 28764000000 15423000000 13341000000 3392 IPI:IPI00217966.9;IPI:IPI00607708.3;IPI:IPI00016768.3;IPI:IPI00554498.3 L-lactate dehydrogenase A chain;LDH muscle subunit;Renal carcinoma antigen NY-REN-59;Cell proliferation-inducing gene 19 protein LDHA;PIG19 P00338-1;P00338;P00338-2 ENST00000227157;ENST00000379412 4 0.74434 1.6124 0.73827 1.0048 1.037 0.98404 Filament;IF_tail cell part;cytoskeletal part;intermediate filament;intracellular organelle part;intracellular part;lamin filament;nuclear part;organelle part structural molecule activity 50 50 47 69.1 69.1 65 66.408 0 10237000000 5425700000 4811500000 3393 IPI:IPI00217975.4 Lamin-B1 LMNB1;LMN2;LMNB P20700 ENST00000261366 K07611 1 0.92673 1.3459 1.133 1.16 0.94788 1.5291 Shugoshin_N chromosome, centromeric region;cohesin complex;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;mitotic cohesin complex;nucleus;organelle;organelle part;protein complex binding;protein binding cell division;cellular process;chromosome segregation;meiotic chromosome segregation 6 6 6 6.2 6.2 6.2 144.74 2.9061E-65 20964000 10798000 10166000 3394 IPI:IPI00657858.1;IPI:IPI00218013.6;IPI:IPI00395828.6 Shugoshin-like 2;Shugoshin-2;Tripin SGOL2 Q562F6-1;Q562F6;Q562F6-2 ENST00000295774;ENST00000357799 K11581 3 0.72091 1.613 0.8295 1.0262 1.0551 1.1241 binding;selenium binding biological regulation;cell redox homeostasis;cellular homeostasis;cellular process;homeostatic process;regulation of biological process;regulation of biological quality;regulation of cellular process 7 7 7 37.7 37.7 37.7 13.406 1.5129E-30 183940000 94469000 89474000 3395 IPI:IPI00218054.2 Selenoprotein H SELH;C11orf31 Q8IZQ5 ENST00000388857 1 NaN NaN 0.79635 NaN NaN 1.0045 Phosphorylase binding;catalytic activity;glycogen phosphorylase activity;lipid binding;nucleotide binding;phosphorylase activity;protein binding;steroid binding;transferase activity;transferase activity, transferring glycosyl groups Insulin signaling pathway;Starch and sucrose metabolism 6 1 1 8 2.3 2.3 97.091 7.8096E-25 5489200 2600100 2889100 3396 IPI:IPI00218130.3 Glycogen phosphorylase, muscle form;Myophosphorylase PYGM P11217 ENST00000164139 K00688 1 0.82119 1.6472 0.80079 1.1378 1.0213 1.1022 COX17 cell part;cytoplasmic part;intracellular organelle part;intracellular part;membrane-enclosed lumen;mitochondrial intermembrane space;mitochondrial part;organelle envelope lumen;organelle part binding;cation binding;copper chaperone activity;copper ion binding;ion binding;metal ion binding;metallochaperone activity;transition metal ion binding cation transport;cellular metabolic process;cellular process;copper ion transport;establishment of localization;generation of precursor metabolites and energy;ion transport;metabolic process;metal ion transport;transition metal ion transport;transport Oxidative phosphorylation 3 3 3 63.5 63.5 63.5 6.9151 1.1843E-46 124590000 71298000 53291000 3397 IPI:IPI00218144.3 Cytochrome c oxidase copper chaperone COX17 Q14061 ENST00000261070 K02260 1 0.93884 1.9919 0.98073 1.3257 1.2742 1.3127 Bap31 endoplasmic reticulum membrane;ER-Golgi intermediate compartment membrane;integral to membrane;integral to plasma membrane;intracellular part;intrinsic to membrane;intrinsic to plasma membrane;membrane;membrane part;organelle membrane;organelle part binding;protein binding;receptor binding apoptosis;cell death;cellular process;death;establishment of protein localization;immune response;immune system process;intracellular protein transport;intracellular transport;programmed cell death;protein transport;transport;vesicle-mediated transport 7 7 7 30.1 30.1 30.1 27.991 3.037E-56 816520000 407990000 408520000 3398 IPI:IPI00218200.8 B-cell receptor-associated protein 31;BCR-associated protein Bap31;p28 Bap31;Protein CDM;6C6-AG tumor-associated antigen BCAP31;BAP31;DXS1357E P51572 ENST00000345046;ENST00000370133 1 0.75312 1.2344 0.76385 0.94214 0.8188 0.98205 Metallophos cell part;cytoplasm;histone methyltransferase complex;intracellular organelle part;intracellular part;macromolecular complex;methyltransferase complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;cation binding;ion binding;iron ion binding;manganese ion binding;metal ion binding;protein binding;transition metal ion binding carbohydrate metabolic process;cell cycle;cellular glucan metabolic process;cellular process;energy reserve metabolic process;generation of precursor metabolites and energy;glycogen metabolic process;metabolic process;polysaccharide metabolic process Focal adhesion;Insulin signaling pathway;Long-term potentiation;Regulation of actin cytoskeleton;Vascular smooth muscle contraction 20 6 6 59.9 26.9 26.9 37.186 0 382510000 199970000 182530000 3399 IPI:IPI00218236.6 Serine/threonine-protein phosphatase PP1-beta catalytic subunit PPP1CB P62140 ENST00000296122;ENST00000358506;ENST00000395366;ENST00000395367 K06269 1 0.60925 1.1218 0.57024 0.81976 0.7283 0.72872 HMG_box;PHD;PWWP;SET cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;DNA binding;methyltransferase activity;N-methyltransferase activity;nucleic acid binding;protein binding;protein methyltransferase activity;S-adenosylmethionine-dependent methyltransferase activity;zinc ion binding biosynthetic process;chromatin organization;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;regulation of transcription, DNA-dependent;transcription Lysine degradation 15 15 15 13.6 13.6 13.6 152.26 4.7356E-174 157550000 85753000 71800000 3400 IPI:IPI00218240.3;IPI:IPI00107486.2;IPI:IPI00334604.6;IPI:IPI00107487.7;IPI:IPI00792674.1;IPI:IPI00790144.1;IPI:IPI00470433.2 Probable histone-lysine N-methyltransferase NSD2;Nuclear SET domain-containing protein 2;Wolf-Hirschhorn syndrome candidate 1 protein;Multiple myeloma SET domain-containing protein;Protein trithorax-5 WHSC1;KIAA1090;MMSET;NSD2;TRX5 O96028-1;O96028;O96028-3;O96028-5 ENST00000312087;ENST00000350915;ENST00000353275;ENST00000382889;ENST00000382891;ENST00000382892;ENST00000382895 K11424 7 0.80058 1.5481 0.78148 1.0378 1.0026 1.0174 VASP_tetra;WH1 adherens junction;cell junction;cell projection;cell-substrate adherens junction;cell-substrate junction;cytoplasm;cytoskeleton;focal adhesion;intracellular organelle;lamellipodium;non-membrane-bounded organelle;organelle actin binding;binding;cytoskeletal protein binding;profilin binding;protein binding;protein domain specific binding;SH3 domain binding actin filament organization;actin polymerization or depolymerization;cell communication;cell surface receptor linked signal transduction;cytoskeleton organization;nervous system development;organelle organization;signal transduction 15 15 15 46.4 46.4 46.4 44.791 5.7583E-161 1396100000 737030000 659060000 3401 IPI:IPI00218245.1;IPI:IPI00170979.1 Ena/VASP-like protein;Ena/vasodilator-stimulated phosphoprotein-like EVL;RNB6 Q9UI08-2;Q9UI08;Q9UI08-1 ENST00000355449;ENST00000392920;ENST00000402714 2 0.72599 1.276 0.72871 0.97191 0.79434 0.94659 Guanylate_kin;L27;PDZ;SH3_2 cell fraction;cell part;cell surface;insoluble fraction;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane fraction;membrane part;plasma membrane part binding;catalytic activity;guanylate kinase activity;kinase activity;nucleotide kinase activity;phosphotransferase activity, phosphate group as acceptor;protein binding;transferase activity;transferase activity, transferring phosphorus-containing groups biological regulation;cell communication;cellular process;regulation of biological process;regulation of cellular process;signal transduction 2 2 2 3.7 3.7 3.7 66.807 9.0909E-05 434580000 237730000 196850000 3402 IPI:IPI00218271.5;IPI:IPI00793074.1;IPI:IPI00747682.1 MAGUK p55 subfamily member 2;Protein MPP2;Discs large homolog 2 MPP2;DLG2 Q14168-3;Q14168;Q14168-1;Q14168-2 ENST00000225995;ENST00000269095;ENST00000377184 3 0.99242 1.5543 1.0451 1.3427 1.1205 1.4084 Gelsolin;Sec23_BS;Sec23_helical;Sec23_trunk;zf-Sec23_Sec24 COPII vesicle coat;endoplasmic reticulum membrane;endoplasmic reticulum part;Golgi apparatus part;intracellular part;macromolecular complex;membrane;membrane coat;membrane part;organelle membrane;organelle part;protein complex;vesicle coat binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding cellular component organization;cellular process;ER to Golgi vesicle-mediated transport;establishment of protein localization;intracellular protein transport;membrane organization;protein transport;transport;vesicle-mediated transport 11 10 10 13.8 12.4 12.4 113.08 3.1998E-28 55966000 28019000 27947000 3404 IPI:IPI00218288.6;IPI:IPI00747830.2 Protein transport protein Sec24D;SEC24-related protein D SEC24D;KIAA0755 O94855-2;O94855;O94855-1 ENST00000280551;ENST00000379735 2 0.92361 1.5723 0.95443 1.2345 1.0272 1.2328 UFD1 cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;cysteine-type peptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides;protein binding;small conjugating protein-specific protease activity;ubiquitin-specific protease activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein metabolic process;proteolysis;skeletal system development;ubiquitin-dependent protein catabolic process 12 12 12 41.1 41.1 41.1 38.725 1.4171E-236 342480000 167350000 175130000 3405 IPI:IPI00655754.1;IPI:IPI00218292.2 Ubiquitin fusion degradation protein 1 homolog UFD1L Q92890-1;Q92890;Q92890-2 ENST00000263202;ENST00000399525 2 0.80476 1.8227 0.86453 1.0718 1.1121 1.2094 Tropomyosin cell part;contractile fiber part;cytoplasmic part;cytoskeletal part;intracellular organelle part;intracellular part;muscle thin filament tropomyosin;organelle part actin binding;binding;cytoskeletal protein binding;protein binding biological regulation;cell motion;cellular process;regulation of biological process;regulation of multicellular organismal process;regulation of muscle contraction;regulation of system process Cardiac muscle contraction;Pathways in cancer;Thyroid cancer 30 30 2 72.6 72.6 8.9 29.032 0 13493000000 6921700000 6570900000 3406 IPI:IPI00218319.3;IPI:IPI00844078.2;IPI:IPI00900375.1 Tropomyosin alpha-3 chain;Tropomyosin-3;Gamma-tropomyosin;Tropomyosin-5 TPM3 P06753-2;P06753 ENST00000271850;ENST00000330188;ENST00000368527;ENST00000368533 K09290 3 1.1518 2.2866 0.97475 1.5326 1.4953 1.2812 HMG_box;SAND;Sp100 cell part;chromosome;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear body;nuclear part;nucleoplasm part;organelle;organelle part;PML body binding;DNA binding;nucleic acid binding;protein binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription corepressor activity;transcription factor binding;transcription repressor activity negative regulation of transcription from RNA polymerase II promoter;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;response to DNA damage stimulus;response to stress 3 3 1 4 4 1.8 101.54 2.1069E-14 87117000 42884000 44233000 3408 IPI:IPI00218326.2 Nuclear autoantigen Sp-100;Nuclear dot-associated Sp100 protein;Speckled 100 kDa;Lysp100b SP100 P23497-4;P23497 ENST00000264052;ENST00000340126;ENST00000341950 1 1.1133 2.239 1.4389 1.4115 1.4166 1.8614 Lectin_leg-like coated vesicle;cytoplasmic membrane-bounded vesicle;endoplasmic reticulum membrane;ER to Golgi transport vesicle;Golgi membrane;Golgi-associated vesicle;integral to membrane;intrinsic to membrane;membrane;organelle membrane;transport vesicle binding;carbohydrate binding;mannose binding;monosaccharide binding;sugar binding cellular biopolymer metabolic process;cellular process;ER to Golgi vesicle-mediated transport;macromolecule metabolic process;metabolic process;protein folding;protein metabolic process;protein transport;transport;vesicle-mediated transport 4 4 4 11.7 11.7 11.7 40.982 0.00056269 22510000 11376000 11134000 3409 IPI:IPI00218337.3;IPI:IPI00744259.1 VIP36-like protein;Lectin mannose-binding 2-like LMAN2L;VIPL;PSEC0028;UNQ368/PRO704 Q9H0V9-2;Q9H0V9;Q9H0V9-1 ENST00000264963;ENST00000377079 K10083 2 0.6675 1.3289 0.67041 0.8784 0.87791 0.87451 FTHFS;THF_DHG_CYH;THF_DHG_CYH_C cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle catalytic activity;formate-tetrahydrofolate ligase activity;methenyltetrahydrofolate cyclohydrolase activity;methylenetetrahydrofolate dehydrogenase activity;nucleoside binding;nucleotide binding;purine nucleoside binding histidine biosynthetic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;purine nucleotide metabolic process;sulfur amino acid biosynthetic process;sulfur amino acid metabolic process Glyoxylate and dicarboxylate metabolism;One carbon pool by folate 44 44 43 51.3 51.3 50.3 101.56 0 5136900000 2900200000 2236700000 3410 IPI:IPI00218342.10 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase MTHFD1;MTHFC;MTHFD P11586 ENST00000216605 K00288;K00295;K01491;K01938 1 0.73325 1.4978 0.73914 0.98315 0.98304 0.97636 Tubulin;Tubulin_C cell part;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;microtubule;organelle part;protein complex binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity;structural molecule activity anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;microtubule-based movement;microtubule-based process;protein complex assembly Gap junction 34 34 2 84.9 84.9 9.1 49.895 0 56758000000 29888000000 26870000000 3411 IPI:IPI00218343.4;IPI:IPI00017454.4 Tubulin alpha-1C chain;Tubulin alpha-6 chain;Alpha-tubulin 6 TUBA1C;TUBA6 Q9BQE3 ENST00000301072 K07374 2 NaN 1.5271 0.91189 NaN 1.0792 1.1258 Aldo_ket_red cell part;cytoplasm;integral to membrane;intracellular part;intrinsic to membrane;membrane part binding;catalytic activity;cation channel activity;cation transmembrane transporter activity;ion channel activity;potassium channel activity;transporter activity;voltage-gated ion channel activity;voltage-gated potassium channel activity cation transport;establishment of localization;ion transport;metabolic process;metal ion transport;monovalent inorganic cation transport;oxidation reduction;potassium ion transport;transport 14 1 1 51 2.8 2.8 39.287 2.1072E-168 35974000 18389000 17585000 3414 IPI:IPI00218374.1 Voltage-gated potassium channel subunit beta-2;K(+) channel subunit beta-2;Kv-beta-2;HKvbeta2 KCNAB2;KCNA2B;KCNK2 Q13303-2;Q13303 ENST00000164247;ENST00000341524;ENST00000352527;ENST00000378083;ENST00000378097 K04883 1 1.1716 NaN 0.82 1.5564 NaN 1.1056 Pam16 cell part;cytoplasmic part;intracellular organelle part;intracellular part;membrane;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part cellular process;establishment of localization;establishment of localization in cell;establishment of protein localization;intracellular protein transport;intracellular transport;protein transport;transmembrane transport;transport 3 3 3 32.8 32.8 32.8 13.825 3.8675E-102 40082000 20004000 20078000 3416 IPI:IPI00218463.3 Mitochondrial import inner membrane translocase subunit Tim16;Mitochondria-associated granulocyte macrophage CSF-signaling molecule TIMM16;MAGMAS;TIM16;CGI-136 Q9Y3D7 ENST00000318059 1 0.44895 0.97596 0.41907 0.60129 0.62003 0.56345 PFU;PUL;WD40 enzyme activator activity;enzyme regulator activity;lipase activator activity;phospholipase A2 activator activity;phospholipase activator activity cell communication;cellular lipid metabolic process;cellular metabolic process;cellular process;lipid metabolic process;metabolic process;organophosphate metabolic process;phospholipid metabolic process;primary metabolic process;signal transduction 23 23 23 40.1 40.1 40.1 87.156 0 470850000 269640000 201210000 3417 IPI:IPI00218465.10 Phospholipase A-2-activating protein PLAA;PLAP Q9Y263 ENST00000380083 1 0.81668 NaN NaN 1.0133 NaN NaN Enolase_C;Enolase_N cell part;cytoplasmic part;cytosolic part;intracellular part;macromolecular complex;phosphopyruvate hydratase complex;protein complex binding;carbon-oxygen lyase activity;catalytic activity;cation binding;hydro-lyase activity;ion binding;lyase activity;magnesium ion binding;metal ion binding;phosphopyruvate hydratase activity alcohol metabolic process;carbohydrate metabolic process;catabolic process;cellular process;generation of precursor metabolites and energy;glucose catabolic process;glucose metabolic process;glycolysis;metabolic process;monosaccharide metabolic process Glycolysis / Gluconeogenesis 6 1 1 18.2 3.2 3.2 46.931 1.664E-206 42635000 21519000 21116000 3419 IPI:IPI00218474.6;IPI:IPI00909949.1;IPI:IPI00942494.1 Beta-enolase;2-phospho-D-glycerate hydro-lyase;Muscle-specific enolase;Skeletal muscle enolase;Enolase 3 ENO3 P13929-1;P13929;P13929-2;P13929-3 ENST00000323997;ENST00000381335 K01689 3 0.90635 1.6636 0.92417 1.1747 1.1377 1.2095 Pribosyltran cell part;cytoplasmic part;cytosol;intracellular part binding;catalytic activity;hypoxanthine phosphoribosyltransferase activity;magnesium ion binding;protein binding;transferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring pentosyl groups nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein complex assembly;purine base metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;purine ribonucleoside salvage Drug metabolism - other enzymes;Purine metabolism 11 11 11 58.3 58.3 58.3 24.579 9.7912E-193 2027400000 1037100000 990360000 3420 IPI:IPI00218493.7 Hypoxanthine-guanine phosphoribosyltransferase HPRT1;HPRT P00492 ENST00000298556;ENST00000370796 K00760 1 0.32051 0.65454 0.44884 0.40788 0.47372 0.56506 Pur_DNA_glyco cell part;cytoplasm;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part alkylbase DNA N-glycosylase activity;binding;catalytic activity;damaged DNA binding;DNA binding;hydrolase activity;hydrolase activity, acting on glycosyl bonds;hydrolase activity, hydrolyzing N-glycosyl compounds;nucleic acid binding;protein binding alcohol metabolic process;carbohydrate metabolic process;D-ribose metabolic process;monosaccharide metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;purine nucleotide metabolic process Base excision repair 9 9 9 42.3 42.3 42.3 32.868 1.5452E-68 77800000 34529000 43272000 3421 IPI:IPI00295497.2;IPI:IPI00218495.3 DNA-3-methyladenine glycosylase;3-methyladenine DNA glycosidase;ADPG;3-alkyladenine DNA glycosylase;N-methylpurine-DNA glycosylase MPG;AAG;ANPG;MID1 P29372-1;P29372;P29372-2 ENST00000219431;ENST00000356432;ENST00000397818 K03652 2 0.77538 1.2819 0.83134 0.95093 0.88434 1.1118 UPF0224 binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding 6 6 6 34.7 34.7 34.7 19.266 1.4331E-24 231640000 112320000 119320000 3422 IPI:IPI00218505.7 Gametocyte-specific factor 1;Protein FAM112B GTSF1;FAM112B Q8WW33 ENST00000305879 1 0.61311 0.97515 0.57694 0.81523 0.62791 0.69692 Runt;RunxI cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;DNA binding;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;transcription activator activity;transcription factor activity;transcription regulator activity nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;positive regulation of myeloid leukocyte differentiation;regulation of immune system process;regulation of myeloid leukocyte differentiation;transcription Acute myeloid leukemia;Chronic myeloid leukemia;Pathways in cancer 10 10 10 28.1 28.1 28.1 51.818 9.67E-220 650070000 347170000 302910000 3423 IPI:IPI00939238.1;IPI:IPI00218529.2;IPI:IPI00218943.5;IPI:IPI00477787.2;IPI:IPI00218936.2;IPI:IPI00218530.2;IPI:IPI00797455.2;IPI:IPI00936936.1;IPI:IPI00218942.2;IPI:IPI00877035.3;IPI:IPI00939601.1 Runt-related transcription factor 1;Core-binding factor subunit alpha-2;Acute myeloid leukemia 1 protein;Oncogene AML-1;Polyomavirus enhancer-binding protein 2 alpha B subunit;SL3-3 enhancer factor 1 alpha B subunit;SL3/AKV core-binding factor alpha B subunit RUNX1;AML1;CBFA2 Q01196-8;Q01196;Q01196-10;Q01196-9;Q01196-1;Q01196-2;Q01196-11;Q01196-4;Q01196-3;Q01196-7 ENST00000300305;ENST00000325074;ENST00000342083;ENST00000344691;ENST00000399245 K08367 11 0.44642 1.0054 0.41021 0.59935 0.66553 0.59337 Pkinase cell part;cytoplasmic part;cytosol;intracellular part catalytic activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;receptor signaling protein serine/threonine kinase activity activation of immune response;immune response-activating cell surface receptor signaling pathway;immune system process;positive regulation of cytokine production;regulation of cytokine production;regulation of immune system process Adherens junction;MAPK signaling pathway;T cell receptor signaling pathway;Toll-like receptor signaling pathway;Wnt signaling pathway 3 3 3 6.8 6.8 6.8 67.195 5.4173E-09 4137200 2536600 1600600 3424 IPI:IPI00295738.1;IPI:IPI00218566.1;IPI:IPI00218567.1 Mitogen-activated protein kinase kinase kinase 7;Transforming growth factor-beta-activated kinase 1 MAP3K7;TAK1 O43318-1;O43318;O43318-2;O43318-3 ENST00000369325;ENST00000369329;ENST00000369332 K04427 3 1.3154 2.7235 1.4078 1.66 1.7413 1.7572 Pterin_4a cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 4-alpha-hydroxytetrahydrobiopterin dehydratase activity;binding;catalytic activity;lyase activity;protein binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding aromatic compound biosynthetic process;biosynthetic process;cellular aromatic compound metabolic process;cellular process;heterocycle biosynthetic process;metabolic process;nitrogen compound metabolic process;tetrahydrobiopterin biosynthetic process 5 5 5 49 49 49 11.999 6.5549E-48 306070000 144340000 161730000 3425 IPI:IPI00218568.7 Pterin-4-alpha-carbinolamine dehydratase;4-alpha-hydroxy-tetrahydropterin dehydratase;Phenylalanine hydroxylase-stimulating protein;Pterin carbinolamine dehydratase;Dimerization cofactor of hepatocyte nuclear factor 1-alpha PCBD1;DCOH;PCBD P61457 ENST00000299299 K01724 1 0.67757 1.2816 0.66457 0.86981 0.83485 0.87249 SH2;Y_phosphatase cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;phosphatase activity;phosphoprotein phosphatase activity;phosphoric ester hydrolase activity;protein binding;protein tyrosine phosphatase activity apoptosis;cell communication;cell surface receptor linked signal transduction;phosphate metabolic process;phosphorus metabolic process;protein amino acid dephosphorylation;protein modification process;signal transduction Adherens junction;B cell receptor signaling pathway;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway 27 27 27 55.1 55.1 55.1 67.718 0 1045700000 570530000 475180000 3426 IPI:IPI00396552.2;IPI:IPI00218604.6;IPI:IPI00183046.2 Tyrosine-protein phosphatase non-receptor type 6;Protein-tyrosine phosphatase 1C;Hematopoietic cell protein-tyrosine phosphatase;SH-PTP1;Protein-tyrosine phosphatase SHP-1 PTPN6;HCP;PTP1C P29350-3;P29350;P29350-1;P29350-2 ENST00000318974;ENST00000399448 K05697 3 0.6858 1.5029 0.70384 0.92472 0.94242 0.97092 Ribosomal_S12 cell part;cytoplasmic part;cytosolic part;cytosolic small ribosomal subunit;intracellular organelle part;intracellular part;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 6 6 6 44.8 44.8 44.8 15.807 9.8836E-43 5239400000 2890200000 2349200000 3427 IPI:IPI00218606.7 40S ribosomal protein S23 RPS23 P62266 ENST00000296674 K02973 1 0.89753 1.9152 0.9849 1.2759 1.1807 1.3102 dsrm;G-patch cell part;intracellular organelle part;intracellular part;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part binding;DNA binding;double-stranded RNA binding;nucleic acid binding;protein binding;RNA binding anti-apoptosis;negative regulation of apoptosis;negative regulation of biological process;negative regulation of programmed cell death;regulation of apoptosis;regulation of cell death;regulation of programmed cell death 25 25 25 15.8 15.8 15.8 267.05 3.1227E-270 609730000 301120000 308610000 3428 IPI:IPI00218620.1;IPI:IPI00218624.1;IPI:IPI00000192.2;IPI:IPI00218622.1;IPI:IPI00748258.2;IPI:IPI00218619.1;IPI:IPI00218618.1;IPI:IPI00217930.1;IPI:IPI00218617.3;IPI:IPI00218621.1 SON protein;SON3;Negative regulatory element-binding protein;DBP-5;Bax antagonist selected in saccharomyces 1 SON;C21orf50;DBP5;KIAA1019;NREBP P18583-5;P18583;P18583-9;P18583-1;P18583-7;P18583-2;P18583-4;P18583-3;P18583-10;P18583-8;P18583-6 ENST00000290239;ENST00000300278;ENST00000321758;ENST00000356577;ENST00000381679;ENST00000381695 10 1.168 2.4895 NaN 1.5838 1.5757 NaN ITAM cell part;cytoplasm;integral to membrane;intracellular part;intrinsic to membrane;macromolecular complex;membrane part;plasma membrane part;protein complex;receptor complex;T cell receptor complex binding;identical protein binding;molecular transducer activity;protein binding;protein dimerization activity;protein homodimerization activity;receptor activity;signal transducer activity;transmembrane receptor activity cell communication;cell surface receptor linked signal transduction;cellular process;interspecies interaction between organisms;multi-organism process;regulation of biological process;regulation of cellular process;signal transduction 3 3 3 24.4 24.4 24.4 18.696 5.0044E-85 5079600 2548800 2530800 3429 IPI:IPI00218634.6;IPI:IPI00375504.1 T-cell surface glycoprotein CD3 zeta chain;T-cell receptor T3 zeta chain CD247;CD3Z;T3Z;TCRZ P20963-1;P20963;P20963-3 ENST00000361719;ENST00000362089;ENST00000367860 2 0.57895 NaN NaN 0.84377 NaN NaN Ins145_P3_rec;Ion_trans;MIR;RIH_assoc;RYDR_ITPR cytoplasmic vesicle membrane;endoplasmic reticulum membrane;integral to membrane;intrinsic to membrane;membrane;organelle membrane;platelet dense granule membrane;platelet dense tubular network membrane;secretory granule membrane;vesicle membrane calcium channel activity;cation channel activity;inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity;intracellular ligand-gated ion channel activity;ion channel activity;receptor activity;signal transducer activity;transporter activity calcium ion transport;cation transport;cell communication;cell death;cellular process;death;di-, tri-valent inorganic cation transport;ion transport;metal ion transport;response to hypoxia;response to stress;signal transduction;transport Alzheimer's disease;Calcium signaling pathway;Gap junction;GnRH signaling pathway;Huntington's disease;Long-term depression;Long-term potentiation;Phosphatidylinositol signaling system;Vascular smooth muscle contraction 3 1 1 2 1.1 1.1 313.94 4.9279E-28 337960 228690 109270 3430 IPI:IPI00333753.4;IPI:IPI00218658.1;IPI:IPI00218662.3;IPI:IPI00925443.1;IPI:IPI00218661.1;IPI:IPI00218664.1;IPI:IPI00218659.1;IPI:IPI00218660.3 Inositol 1,4,5-trisphosphate receptor type 1;Type 1 inositol 1,4,5-trisphosphate receptor;Type 1 InsP3 receptor;IP3 receptor isoform 1;InsP3R1 ITPR1;INSP3R1 Q14643-1;Q14643;Q14643-2;Q14643-6;Q14643-7;Q14643-5;Q14643-8;Q14643-3;Q14643-4 ENST00000302640;ENST00000354582;ENST00000356617;ENST00000357086 K04958 8 1.3379 2.4117 1.3428 1.7691 1.6483 1.935 2OG-FeII_Oxy;P4Ha_N endoplasmic reticulum;endoplasmic reticulum lumen;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;membrane-enclosed lumen;mitochondrion;organelle;organelle lumen;organelle part binding;catalytic activity;iron ion binding;oxidoreductase activity;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen;procollagen-proline 4-dioxygenase activity metabolic process;oxidation reduction Arginine and proline metabolism 17 17 17 36.9 36.9 36.9 60.966 2.4332E-150 209020000 97099000 111920000 3431 IPI:IPI00218682.1;IPI:IPI00009923.1 Prolyl 4-hydroxylase subunit alpha-1;4-PH alpha-1;Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1 P4HA1;P4HA P13674-2;P13674;P13674-1 ENST00000263556;ENST00000307116;ENST00000394890 K00472 2 0.79842 1.6669 0.7749 1.0246 1.1782 1.0268 Pribosyltran cell part;cytoplasmic part;cytosol;intracellular part adenine phosphoribosyltransferase activity;AMP binding;binding;catalytic activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;transferase activity;transferase activity, transferring glycosyl groups cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside metabolic process;purine ribonucleoside salvage;ribonucleoside metabolic process Purine metabolism 12 12 12 73.3 73.3 73.3 19.608 1.1163E-212 1675200000 890000000 785150000 3432 IPI:IPI00218693.8 Adenine phosphoribosyltransferase APRT P07741 ENST00000378364 K00759 1 0.59764 1.1301 0.57695 0.77311 0.74156 0.76689 LisH;WD40 astral microtubule;cell cortex;centrosome;cilium;cytoplasmic microtubule;cytosol;kinetochore;membrane;microtubule;microtubule associated complex;microtubule organizing center;motile primary cilium;nuclear membrane;organelle membrane;spindle microtubule binding;carbohydrate binding;cytoskeletal protein binding;dynactin binding;enzyme binding;glycosaminoglycan binding;heparin binding;identical protein binding;microtubule binding;pattern binding;polysaccharide binding;protein binding;tubulin binding acrosome assembly;alcohol metabolic process;cellular amino acid and derivative metabolic process;establishment of mitotic spindle orientation;microtubule cytoskeleton organization;neuron migration;nuclear division;system process Ether lipid metabolism 18 18 18 52.9 52.9 52.9 46.637 0 1001700000 561530000 440170000 3433 IPI:IPI00218728.4;IPI:IPI00760905.2 Platelet-activating factor acetylhydrolase IB subunit alpha;PAF acetylhydrolase 45 kDa subunit;PAF-AH alpha;PAFAH alpha;Lissencephaly-1 protein PAFAH1B1;LIS1;MDCR;MDS;PAFAHA P43034-1;P43034 ENST00000006951;ENST00000397195 K01062 2 0.92321 1.9521 0.99531 1.3516 1.2155 1.3036 Sod_Cu cell projection cytoplasm;cell soma;cytoplasmic vesicle;cytosol;dendrite cytoplasm;extracellular matrix;extracellular space;macromolecular complex;membrane-bounded organelle;microbody;mitochondrial matrix;nucleus;organelle;peroxisome;vesicle antioxidant activity;binding;catalytic activity;copper ion binding;enzyme binding;oxidoreductase activity;oxidoreductase activity, acting on superoxide radicals as acceptor;phosphatase binding;protein binding;superoxide dismutase activity;zinc ion binding activation of MAPK activity;DNA catabolic process, endonucleolytic;leukocyte homeostasis;ovarian follicle development;regulation of cytokine production;response to oxygen radical;response to reactive oxygen species;response to superoxide Amyotrophic lateral sclerosis (ALS);Huntington's disease 13 13 13 86.4 86.4 86.4 15.936 0 4169900000 2172100000 1997800000 3434 IPI:IPI00218733.6 Superoxide dismutase [Cu-Zn] SOD1 P00441 ENST00000270142 K04565 1 0.87464 1.5711 0.87781 1.1643 1.0184 1.1545 DNA_gyraseB;DNA_topoisoIV;DTHCT;HATPase_c chromosome;cytoplasm;DNA topoisomerase complex (ATP-hydrolyzing);intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nucleoplasm;organelle;organelle part;protein complex binding;catalytic activity;chromatin binding;DNA binding;DNA topoisomerase (ATP-hydrolyzing) activity;DNA topoisomerase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;protein kinase C binding;purine nucleoside binding DNA ligation;DNA metabolic process;DNA packaging;DNA repair;DNA replication;DNA topological change;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to DNA damage stimulus;response to stress 45 45 34 29.5 29.5 22.6 182.68 0 2349300000 1181800000 1167500000 3435 IPI:IPI00879004.1;IPI:IPI00218753.1;IPI:IPI00414101.4;IPI:IPI00478232.3 DNA topoisomerase 2-alpha;DNA topoisomerase II, alpha isozyme TOP2A;TOP2 P11388-4;P11388;P11388-3;P11388-2;P11388-1 ENST00000269577;ENST00000348049;ENST00000357601 K03164 4 0.5197 1.441 0.47486 0.78937 0.88155 0.73298 FKBP_C;TPR_1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;cis-trans isomerase activity;drug binding;FK506 binding;heat shock protein binding;isomerase activity;macrolide binding;peptidyl-prolyl cis-trans isomerase activity;protein binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 11 11 11 24.1 24.1 24.1 51.212 2.2148E-114 108290000 61822000 46471000 3436 IPI:IPI00218775.2 FK506-binding protein 5;Peptidyl-prolyl cis-trans isomerase;51 kDa FK506-binding protein;FKBP-51;54 kDa progesterone receptor-associated immunophilin;FKBP54;FF1 antigen;HSP90-binding immunophilin;Androgen-regulated protein 6 FKBP5;AIG6;FKBP51 Q13451 ENST00000337746;ENST00000357266 K09571 1 0.54733 1.0154 0.54705 0.74028 0.68216 0.76567 Y_phosphatase cell part;cytoplasm;intracellular part binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;phosphatase activity;phosphoprotein phosphatase activity;phosphoric ester hydrolase activity;protein binding;protein tyrosine phosphatase activity cellular biopolymer metabolic process;cellular process;dephosphorylation;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid dephosphorylation;protein metabolic process;protein modification process 9 9 9 28.2 28.2 28.2 48.473 1.7757E-78 258070000 145640000 112430000 3437 IPI:IPI00219695.4;IPI:IPI00218788.1 Tyrosine-protein phosphatase non-receptor type 2;T-cell protein-tyrosine phosphatase PTPN2;PTPT P17706-1;P17706;P17706-2 ENST00000309660;ENST00000327283 K01104 2 0.74646 1.737 0.7129 0.96706 1.0625 0.92548 EGF;Lectin_C;Sushi cell part;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part binding;carbohydrate binding;glycolipid binding;glycosaminoglycan binding;glycosphingolipid binding;heparin binding;lipid binding;pattern binding;polysaccharide binding;protein binding;sphingolipid binding;sugar binding biological adhesion;cell adhesion;cellular process Cell adhesion molecules (CAMs) 3 3 3 7 7 7 43.617 2.057E-05 87997000 48443000 39554000 3438 IPI:IPI00218795.1 L-selectin;Lymph node homing receptor;Leukocyte adhesion molecule 1;Leukocyte surface antigen Leu-8;TQ1;gp90-MEL;Leukocyte-endothelial cell adhesion molecule 1;CD62 antigen-like family member L SELL;LNHR;LYAM1 P14151 ENST00000236147 K06495 1 0.74776 1.3825 0.71715 1.0085 0.89435 0.98258 GTP_EFTU;GTP_EFTU_D2;GTP_EFTU_D3;PAM2 cell part;cytoplasm;intracellular;intracellular part binding;catalytic activity;GTP binding;GTPase activity;nucleic acid binding;nucleotide binding;protein binding;translation factor activity, nucleic acid binding;translation release factor activity;translation termination factor activity G1/S transition of mitotic cell cycle;nuclear-transcribed mRNA catabolic process;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA catabolic process 19 19 19 42.3 42.3 42.3 55.755 4.0277E-218 1412300000 750770000 661580000 3439 IPI:IPI00218829.9;IPI:IPI00642097.1 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;G1 to S phase transition protein 1 homolog;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B;G1 to S phase transition protein 2 homolog GSPT1;ERF3A;GSPT2;ERF3B P15170;Q8IYD1 ENST00000219627;ENST00000340438 2 0.72562 1.5174 0.74653 0.97598 0.9723 1.0262 GST_C;GST_N cell part;cytoplasm;intracellular part catalytic activity;glutathione transferase activity;transferase activity;transferase activity, transferring alkyl or aryl (other than methyl) groups metabolic process Drug metabolism - cytochrome P450;Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450 8 8 1 37.6 37.6 4.1 25.712 5.2615E-139 373790000 205020000 168770000 3440 IPI:IPI00218831.4;IPI:IPI00152326.3 Glutathione S-transferase Mu 1;GSTM1-1;GST class-mu 1;GSTM1a-1a;GSTM1b-1b;HB subunit 4;GTH4 GSTM1;GST1 P09488-1;P09488;P09488-2 ENST00000309851;ENST00000369823 K00799 2 0.64962 1.9135 0.71799 0.87325 1.2682 0.90548 ATP-synt_E intracellular part;macromolecular complex;membrane part;mitochondrial proton-transporting ATP synthase complex, coupling factor F(o);organelle part;protein complex;proton-transporting two-sector ATPase complex, proton-transporting domain cation transmembrane transporter activity;hydrogen ion transmembrane transporter activity;ion transmembrane transporter activity;monovalent inorganic cation transmembrane transporter activity;transmembrane transporter activity;transporter activity ATP biosynthetic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;transport Oxidative phosphorylation 4 4 4 54.2 54.2 54.2 8.3076 4.4493E-46 127350000 70704000 56643000 3441 IPI:IPI00218848.5 ATP synthase subunit e, mitochondrial ATP5I;ATP5K P56385 ENST00000304312 K02129 1 1.0119 1.8362 0.98703 1.2935 1.2401 1.2348 SCAMP cytoplasmic part;endosomal part;endosome membrane;Golgi apparatus part;Golgi membrane;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part;trans-Golgi network membrane binding;protein binding cellular process;establishment of localization;establishment of protein localization;Golgi vesicle transport;intracellular transport;post-Golgi vesicle-mediated transport;protein transport;transport;vesicle-mediated transport 4 4 4 14.3 14.3 14.3 36.648 6.9467E-90 102690000 51704000 50984000 3442 IPI:IPI00218850.5 Secretory carrier-associated membrane protein 2 SCAMP2 O15127 ENST00000268099 1 0.39213 1.1016 NaN 0.54245 0.69949 NaN Pkinase catalytic activity;MAP kinase kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;protein serine/threonine/tyrosine kinase activity;purine nucleoside binding positive regulation of biosynthetic process;positive regulation of metabolic process;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of transcription, DNA-dependent Amyotrophic lateral sclerosis (ALS);Fc epsilon RI signaling pathway;GnRH signaling pathway;MAPK signaling pathway;Toll-like receptor signaling pathway 7 7 7 26.4 26.4 26.4 39.94 1.704E-49 8672000 4898200 3773800 3443 IPI:IPI00218858.1;IPI:IPI00220438.1;IPI:IPI00218857.1 Dual specificity mitogen-activated protein kinase kinase 3;MAPK/ERK kinase 3 MAP2K3;MEK3;MKK3;PRKMK3 P46734-3;P46734;P46734-1;P46734-2 ENST00000316920;ENST00000342679;ENST00000361818;ENST00000395492 K04432 3 0.64198 1.2814 0.63908 0.87725 0.81483 0.84449 RNA_pol_Rpb7_N;S1 cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;catalytic activity;DNA-directed RNA polymerase activity;nucleic acid binding;nucleotidyltransferase activity;protein binding;RNA binding;RNA polymerase activity;transferase activity;transferase activity, transferring phosphorus-containing groups nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile Huntington's disease;RNA polymerase 5 5 5 38.4 38.4 38.4 19.294 4.9936E-95 276210000 194960000 81249000 3444 IPI:IPI00218895.6 DNA-directed RNA polymerase II subunit RPB7;DNA-directed RNA polymerase II subunit G;DNA-directed RNA polymerase II 19 kDa polypeptide POLR2G P62487 ENST00000301788 K03015 1 0.88864 2.2154 0.91674 1.2298 1.4553 1.2044 Annexin basolateral plasma membrane;cell projection;cilium;cornified envelope;cytoplasm;cytoskeleton;intracellular membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle binding;calcium ion binding;calcium-dependent phospholipid binding;enzyme inhibitor activity;lipid binding;phospholipase inhibitor activity;phospholipid binding;protein binding;receptor binding;structural molecule activity anti-apoptosis;cell communication;cell motion;cell surface receptor linked signal transduction;defense response;inflammatory response;lipid metabolic process;metabolic process;protein modification process;response to stress;signal transduction 28 28 28 72.8 72.8 72.8 38.714 0 2507500000 1344100000 1163400000 3445 IPI:IPI00218918.5 Annexin A1;Annexin-1;Annexin I;Lipocortin I;Calpactin II;Chromobindin-9;p35;Phospholipase A2 inhibitory protein ANXA1;ANX1;LPC1 P04083 ENST00000257497;ENST00000376911 1 0.73656 1.8999 0.81045 0.98923 1.2597 0.99529 DnaJ;Sec63 cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part binding;heat shock protein binding;molecular transducer activity;protein binding;receptor activity;signal transducer activity;unfolded protein binding cellular biopolymer metabolic process;cellular process;intracellular protein transport;macromolecule metabolic process;metabolic process;protein folding;protein metabolic process;protein targeting;protein targeting to membrane;protein transport;transport 8 8 8 13.9 13.9 13.9 87.996 1.2648E-48 61652000 34774000 26879000 3446 IPI:IPI00218922.5 Translocation protein SEC63 homolog SEC63;SEC63L Q9UGP8 ENST00000369002 K09540 1 0.77888 1.6852 0.91992 1.0995 1.051 1.2845 efhand cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle auxiliary transport protein activity;binding;calcium ion binding;cation binding;channel regulator activity;ion binding;metal ion binding;potassium channel regulator activity cation transport;cell communication;cellular process;intracellular signaling cascade;ion transport;metal ion transport;monovalent inorganic cation transport;potassium ion transport;signal transduction;small GTPase mediated signal transduction;transport Alzheimer's disease;Amyotrophic lateral sclerosis (ALS);Apoptosis;Axon guidance;B cell receptor signaling pathway;Calcium signaling pathway;Long-term potentiation;MAPK signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;VEGF signaling pathway;Wnt signaling pathway 7 7 7 41 41 41 22.456 5.2306E-30 67678000 32882000 34796000 3447 IPI:IPI00218924.5 Calcium-binding protein p22;Calcium-binding protein CHP;Calcineurin homologous protein;Calcineurin B homolog CHP Q99653 ENST00000334660;ENST00000366273 K06268 1 0.42139 7.9566 1.1502 0.56301 5.2675 1.4416 PP2C cell part;cytoplasmic part;intracellular organelle part;intracellular part;macromolecular complex;mitochondrial matrix;mitochondrial part;organelle part;protein complex;protein serine/threonine phosphatase complex [pyruvate dehydrogenase (lipoamide)] phosphatase activity;binding;calcium ion binding;catalytic activity;hydrolase activity;magnesium ion binding;phosphoprotein phosphatase activity;protein serine/threonine phosphatase activity cellular biopolymer metabolic process;cellular process;dephosphorylation;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid dephosphorylation;protein metabolic process;protein modification process + 3 3 3 6.9 6.9 6.9 61.053 1.8333E-18 11993000 5469900 6523400 3448 IPI:IPI00218971.4 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial;Pyruvate dehydrogenase phosphatase, catalytic subunit 1;Protein phosphatase 2C PDP1;PDP;PPM2C Q9P0J1 ENST00000297598;ENST00000396200 K01102 1 1.6082 3.5498 1.7409 2.1673 2.2206 2.1496 HSP70 cell part;cytoplasm;intracellular part adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding response to biotic stimulus;response to chemical stimulus;response to organic substance;response to protein stimulus;response to stimulus;response to stress;response to unfolded protein 15 12 12 21.3 18.4 18.4 96.864 2.7237E-175 72444000 39295000 33148000 3449 IPI:IPI00939163.1;IPI:IPI00513743.1;IPI:IPI00218993.1 Heat shock protein 105 kDa;Heat shock 110 kDa protein;Antigen NY-CO-25 HSPH1;HSP105;HSP110;KIAA0201 Q92598-1;Q92598;Q92598-3;Q92598-2 ENST00000320027;ENST00000380405 K09485 3 0.89624 1.775 0.94177 1.2411 1.138 1.261 FKBP_C;TPR_1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;cis-trans isomerase activity;drug binding;FK506 binding;heat shock protein binding;isomerase activity;macrolide binding;peptidyl-prolyl cis-trans isomerase activity;protein binding;protein binding, bridging biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 40 40 40 80.6 80.6 80.6 51.804 0 5539500000 2853100000 2686400000 3450 IPI:IPI00219005.3 FK506-binding protein 4;Peptidyl-prolyl cis-trans isomerase;HSP-binding immunophilin;FKBP52 protein;52 kDa FK506-binding protein;FKBP59;p59 protein FKBP4 Q02790 ENST00000001008 K09571 1 0.41279 0.91845 0.6276 0.67713 0.59503 0.76963 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;nucleoplasm;organelle;organelle part binding;protein binding 2 2 2 25 25 25 15.434 6.5712E-62 48474000 26357000 22118000 3451 IPI:IPI00219006.5 Active regulator of SIRT1;40S ribosomal protein S19-binding protein 1 RPS19BP1;AROS Q86WX3 ENST00000334678 1 0.73302 1.5163 0.71725 0.97169 1.003 0.94637 Gp_dh_C;Gp_dh_N cell part;cytoplasmic part;intracellular part;membrane;perinuclear region of cytoplasm binding;catalytic activity;glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity;glyceraldehyde-3-phosphate dehydrogenase activity;nucleotide binding;oxidoreductase activity;protein binding alcohol metabolic process;carbohydrate metabolic process;catabolic process;cellular process;generation of precursor metabolites and energy;glucose catabolic process;glucose metabolic process;glycolysis;metabolic process;monosaccharide metabolic process Alzheimer's disease;Glycolysis / Gluconeogenesis 35 35 25 90.7 90.7 82.1 36.053 0 105800000000 55756000000 50044000000 3452 IPI:IPI00219018.7 Glyceraldehyde-3-phosphate dehydrogenase GAPDH;GAPD;CDABP0047;OK/SW-cl.12 P04406 ENST00000229239;ENST00000396859;ENST00000396861;ENST00000406765 K00134 1 0.80032 1.6878 0.79685 1.045 1.1306 1.075 Glutaredoxin cell part;cytoplasmic part;cytosol;intracellular part binding;catalytic activity;disulfide oxidoreductase activity;electron carrier activity;glutathione disulfide oxidoreductase activity;peptide disulfide oxidoreductase activity;protein binding;protein disulfide oxidoreductase activity cell redox homeostasis;cellular homeostasis;cellular metabolic process;cellular process;electron transport chain;generation of precursor metabolites and energy;homeostatic process;metabolic process;regulation of biological process;transport 6 6 6 76.4 76.4 76.4 11.776 9.9669E-64 864840000 470260000 394580000 3453 IPI:IPI00219025.3 Glutaredoxin-1;Thioltransferase-1 GLRX;GRX P35754 ENST00000237858;ENST00000379979 K03676 1 0.92558 1.8432 0.95584 1.2681 1.1949 1.2537 Aminotran_1_2 cell part;cytoplasmic part;cytosol;intracellular part binding;catalytic activity;L-aspartate:2-oxoglutarate aminotransferase activity;lipid binding;pyridoxal phosphate binding;steroid binding;transaminase activity;transferase activity;transferase activity, transferring nitrogenous groups;vitamin binding aspartate catabolic process;aspartate metabolic process;catabolic process;cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;metabolic process;nitrogen compound metabolic process;organic acid metabolic process Alanine and aspartate metabolism;Alkaloid biosynthesis I;Arginine and proline metabolism;Carbon fixation in photosynthetic organisms;Cysteine metabolism;Glutamate metabolism;Novobiocin biosynthesis;Phenylalanine metabolism;Phenylalanine, tyrosine and tryptophan biosynthesis;Tyrosine metabolism 20 20 20 61 61 61 46.247 0 1479400000 765240000 714110000 3454 IPI:IPI00219029.3 Aspartate aminotransferase, cytoplasmic;Transaminase A;Glutamate oxaloacetate transaminase 1 GOT1 P17174 ENST00000370508 K00813 1 0.88035 1.7689 0.91168 1.2114 1.1532 1.1863 CHCH cytoplasmic part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;mitochondrial membrane part;mitochondrial part;mitochondrial respiratory chain complex I;NADH dehydrogenase complex;organelle part;protein complex catalytic activity;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor cellular metabolic process;cellular process;electron transport chain;generation of precursor metabolites and energy;metabolic process;mitochondrial electron transport, NADH to ubiquinone;respiratory electron transport chain;transport Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 10 10 10 63.4 63.4 63.4 20.105 2.5267E-83 413780000 214490000 199280000 3455 IPI:IPI00219034.3 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8;NADH-ubiquinone oxidoreductase 19 kDa subunit;Complex I-19kD;Complex I-PGIV NDUFA8 P51970 ENST00000373768 K03952 1 0.60333 1.5002 0.52231 0.81928 0.86164 0.70673 DEAD;dsrm;dsRNA_bind;Helicase_C;PAZ;Ribonuclease_3 Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;ribonucleoprotein complex;RNAi effector complex;RNA-induced silencing complex catalytic activity;double-stranded RNA binding;endonuclease activity;endoribonuclease activity;helicase activity;magnesium ion binding;nuclease activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;RNA binding anatomical structure formation;cellular component organization;cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to organic substance;RNA processing 4 4 4 2.5 2.5 2.5 218.68 1.106E-39 25677000 14623000 11055000 3456 IPI:IPI00219036.5 Endoribonuclease Dicer;Helicase with RNase motif DICER1;DICER;HERNA;KIAA0928 Q9UPY3 ENST00000343455;ENST00000393063 K11592 1 NaN 1.5136 0.82944 NaN 0.9688 1.1086 Histone cell part;chromosomal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;macromolecular complex;membrane-bounded organelle;nucleosome;nucleus;organelle;organelle part;protein-DNA complex binding;DNA binding;nucleic acid binding anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;chromatin organization;nucleosome assembly;organelle organization Systemic lupus erythematosus 7 1 1 45.6 23.5 23.5 15.328 5.5472E-123 348800000 187790000 161010000 3457 IPI:IPI00219038.9 Histone H3.3 H3F3A;H3.3A;H3F3;PP781;H3F3B;H3.3B P84243 ENST00000254810;ENST00000366813;ENST00000366815;ENST00000366816;ENST00000375183 K11253 1 0.73836 1.3467 NaN 1.0698 0.83642 NaN GST_C;GST_N cell part;cytoplasm;intracellular part catalytic activity;glutathione transferase activity;transferase activity;transferase activity, transferring alkyl or aryl (other than methyl) groups metabolic process Drug metabolism - cytochrome P450;Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450 7 4 3 37.6 22 17.9 25.744 1.1771E-87 25961000 14553000 11408000 3458 IPI:IPI00219067.4 Glutathione S-transferase Mu 2;GSTM2-2;GST class-mu 2 GSTM2;GST4 P28161 ENST00000241337;ENST00000369830 K00799 1 NaN 1.5975 NaN NaN 1.101 NaN Acetyltransf_1 acetyltransferase activity;acyltransferase activity;catalytic activity;N-acetyltransferase activity;N-acyltransferase activity;transferase activity;transferase activity, transferring acyl groups metabolic process 8 8 8 30.9 30.9 30.9 39.319 5.3777E-41 10076000 4878800 5197500 3459 IPI:IPI00219068.3;IPI:IPI00788069.1 N-acetyltransferase MAK3 homolog;N-acetyltransferase 12 NAT12;C14orf35;MAK3 Q147X3-1;Q147X3;Q147X3-2 ENST00000298406;ENST00000395257 2 0.68983 1.2784 0.68768 0.92051 0.84332 0.91107 Leuk-A4-hydro_C;Peptidase_M1 cell part;cytoplasm;intracellular part binding;catalytic activity;epoxide hydrolase activity;ether hydrolase activity;hydrolase activity;hydrolase activity, acting on ether bonds;leukotriene-A4 hydrolase activity;metallopeptidase activity;peptidase activity;protein binding;zinc ion binding fatty acid biosynthetic process;fatty acid metabolic process;icosanoid metabolic process;leukotriene metabolic process;lipid metabolic process;organic acid metabolic process;proteolysis;response to stress;unsaturated fatty acid biosynthetic process Arachidonic acid metabolism 31 31 31 57.9 57.9 57.9 69.284 0 1175900000 645460000 530450000 3460 IPI:IPI00219077.4;IPI:IPI00514090.2 Leukotriene A-4 hydrolase;Leukotriene A(4) hydrolase LTA4H;LTA4 P09960-1;P09960;P09960-2 ENST00000228740 K01254 2 0.82383 1.6844 0.81004 1.1206 1.0789 1.0659 Cation_ATPase_C;Cation_ATPase_N;E1-E2_ATPase;Hydrolase cell fraction;endoplasmic reticulum membrane;insoluble fraction;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane;membrane fraction;microsome;organelle membrane;sarcoplasmic reticulum membrane ATP binding;binding;calcium ion binding;calcium-transporting ATPase activity;catalytic activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;transporter activity ATP biosynthetic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;transport 26 26 21 25.8 25.8 19.1 114.76 0 1830100000 962740000 867310000 3461 IPI:IPI00219078.5;IPI:IPI00177817.4;IPI:IPI00024804.3;IPI:IPI00396118.3 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2;Calcium pump 2;Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform;SR Ca(2+)-ATPase 2;Endoplasmic reticulum class 1/2 Ca(2+) ATPase ATP2A2;ATP2B P16615-1;P16615;P16615-2 ENST00000308664;ENST00000313432 4 0.71259 1.4894 0.8667 0.88797 1.0246 1.0772 RHD;TIG cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex binding;DNA binding;enzyme binding;nucleic acid binding;protein binding;RNA polymerase II transcription factor activity;RNA polymerase II transcription factor activity, enhancer binding;transcription factor activity;transcription factor binding anti-apoptosis;defense response;immune effector process;immune system process;inflammatory response;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to stress;transcription Acute myeloid leukemia;Adipocytokine signaling pathway;Apoptosis;B cell receptor signaling pathway;Chemokine signaling pathway;Chronic myeloid leukemia;Epithelial cell signaling in Helicobacter pylori infection;MAPK signaling pathway;Pancreatic cancer;Pathways in cancer;Prostate cancer;Small cell lung cancer;T cell receptor signaling pathway;Toll-like receptor signaling pathway 6 6 6 15.1 15.1 15.1 60.218 1.9369E-42 73474000 40435000 33039000 3462 IPI:IPI00386448.4;IPI:IPI00479470.2;IPI:IPI00219084.2;IPI:IPI00884950.1 Transcription factor p65;Nuclear factor NF-kappa-B p65 subunit RELA;NFKB3 Q04206-1;Q04206;Q04206-3;Q04206-2;Q04206-4 ENST00000308639;ENST00000406246 K04735 4 0.75901 1.9104 0.86226 1.0767 1.1412 1.2437 HMG_box chromosome;condensed chromosome;cytoplasmic part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;nuclear chromosome;nuclear part;nucleolus;organelle;organelle part binding;DNA bending activity;DNA binding;double-stranded DNA binding;general transcriptional repressor activity;nucleic acid binding;protein binding;single-stranded DNA binding;transcription factor activity;transcription repressor activity base-excision repair, DNA ligation;chromatin organization;DNA ligation;DNA metabolic process;DNA unwinding during replication;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleosome assembly 22 17 17 48.8 35.9 35.9 24.033 7.7204E-274 5304100000 2734500000 2569600000 3463 IPI:IPI00219097.4 High mobility group protein B2;High mobility group protein 2 HMGB2;HMG2 P26583 ENST00000296503 K11295 1 0.88906 1.7224 0.7965 1.2112 1.1024 1.1121 TRAM_LAG1_CLN8;TRAM1 cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part binding;molecular transducer activity;protein binding;receptor activity;signal transducer activity cellular process;cotranslational protein targeting to membrane;establishment of protein localization;intracellular protein transport;intracellular transport;protein targeting;protein targeting to membrane;protein transport;transport 6 6 6 16.3 16.3 16.3 43.071 1.4702E-12 77285000 37359000 39926000 3464 IPI:IPI00219111.7 Translocating chain-associated membrane protein 1 TRAM1;TRAM Q15629 ENST00000262213 1 0.90049 1.8829 0.8839 1.1701 1.1691 1.1625 Flavodoxin_2 cell part;cytoplasm;intracellular part binding;catalytic activity;dihydronicotinamide riboside quinone reductase activity;electron carrier activity;NADPH dehydrogenase (quinone) activity;NADPH dehydrogenase activity;oxidoreductase activity;zinc ion binding metabolic process;oxidation reduction 6 6 6 22.1 22.1 22.1 25.952 5.476E-46 56631000 31258000 25373000 3466 IPI:IPI00219129.9 Ribosyldihydronicotinamide dehydrogenase [quinone];NRH dehydrogenase [quinone] 2;NRH:quinone oxidoreductase 2 NQO2;NMOR2 P16083 ENST00000338130;ENST00000380430;ENST00000380455 K08071 1 0.59749 1.1864 0.7159 0.81927 0.71104 0.98792 CSD cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;double-stranded DNA binding;nucleic acid binding;protein binding;RNA polymerase II transcription factor activity;transcription cofactor activity;transcription corepressor activity;transcription factor activity negative regulation of transcription from RNA polymerase II promoter;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription Tight junction 11 1 1 36.3 7.9 7.9 31.947 0 125260000 68424000 56836000 3467 IPI:IPI00219147.4 DNA-binding protein A;Cold shock domain-containing protein A;Single-strand DNA-binding protein NF-GMB CSDA;DBPA P16989-2;P16989 ENST00000228251;ENST00000279550 K06099 1 0.69915 1.3576 0.72611 0.89501 0.92308 0.91896 Ribosomal_L22e cell part;cytoplasmic part;cytosolic large ribosomal subunit;cytosolic part;intracellular organelle part;intracellular part;large ribosomal subunit;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit binding;carbohydrate binding;glycosaminoglycan binding;heparin binding;nucleic acid binding;pattern binding;polysaccharide binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation 7 7 6 57 57 50.8 14.787 4.5676E-58 3535200000 1831700000 1703500000 3468 IPI:IPI00219153.4 60S ribosomal protein L22;Epstein-Barr virus small RNA-associated protein;EBER-associated protein;Heparin-binding protein HBp15 RPL22 P35268 ENST00000234875 1 0.65174 1.244 0.75156 0.88465 0.81053 1.0049 KOW;Ribosomal_L27e cell part;cytoplasmic part;cytosol;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 11 11 11 54.4 54.4 54.4 15.798 8.9851E-39 5987200000 3133700000 2853500000 3469 IPI:IPI00219155.5 60S ribosomal protein L27 RPL27 P61353 ENST00000253788;ENST00000404124 K02901 1 0.68033 1.4459 0.73549 0.96338 0.91122 0.98966 Ribosomal_L7Ae cell part;cytoplasmic part;cytosolic large ribosomal subunit;cytosolic part;intracellular organelle part;intracellular part;large ribosomal subunit;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit binding;nucleic acid binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 7 7 7 59.1 59.1 59.1 12.784 1.1175E-235 4649300000 2477000000 2172300000 3470 IPI:IPI00219156.7 60S ribosomal protein L30 RPL30 P62888 ENST00000287038;ENST00000396072 K02908 1 0.73313 1.3455 0.86728 0.97121 0.89167 1.1606 Ribosomal_L34e cell part;cytoplasmic part;cytosolic large ribosomal subunit;cytosolic part;intracellular organelle part;intracellular part;large ribosomal subunit;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit binding;nucleic acid binding;protein binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 5 5 5 17.1 17.1 17.1 13.293 1.1873E-17 3188200000 1708000000 1480200000 3471 IPI:IPI00219160.3 60S ribosomal protein L34 RPL34 P49207 ENST00000394665;ENST00000394667;ENST00000394668 K02915 1 0.80459 1.562 0.78026 1.077 1.0095 1.0449 Ldh_1_C;Ldh_1_N cell part;cytoplasm;intracellular part binding;catalytic activity;lactate dehydrogenase activity;L-lactate dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors alcohol metabolic process;carbohydrate metabolic process;catabolic process;cellular process;generation of precursor metabolites and energy;glucose catabolic process;glucose metabolic process;glycolysis;metabolic process;monosaccharide metabolic process Cysteine metabolism;Glycolysis / Gluconeogenesis;Propanoate metabolism;Pyruvate metabolism 28 25 25 64.4 62.6 62.6 36.638 0 22216000000 11783000000 10433000000 3473 IPI:IPI00219217.3 L-lactate dehydrogenase B chain;LDH heart subunit;Renal carcinoma antigen NY-REN-46 LDHB P07195 ENST00000350669;ENST00000396076 K00016 1 1.0039 2.1216 1.0211 1.3764 1.3515 1.3962 Gal-bind_lectin cell part;cytoplasm;extracellular matrix;extracellular region part;extracellular space;intracellular part;proteinaceous extracellular matrix binding;carbohydrate binding;galactoside binding;molecular transducer activity;monosaccharide binding;protein binding;signal transducer activity;sugar binding apoptosis;cell death;cellular process;positive regulation of cell communication;positive regulation of signal transduction;regulation of cell communication;regulation of protein kinase cascade;regulation of signal transduction 9 9 9 61.5 61.5 61.5 14.716 0 3879100000 1999400000 1879700000 3474 IPI:IPI00219219.3 Galectin-1;Lectin galactoside-binding soluble 1;Beta-galactoside-binding lectin L-14-I;S-Lac lectin 1;Galaptin;14 kDa lectin;HPL;HBL;Putative MAPK-activating protein PM12 LGALS1 P09382 ENST00000215909 K06830 1 0.8418 1.5385 0.78973 1.0148 1.1039 0.96692 LSM cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;protein binding;RNA binding cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 4 4 3 27.5 27.5 21.6 11.845 2.6594E-14 672420000 351320000 321090000 3476 IPI:IPI00219229.3 U6 snRNA-associated Sm-like protein LSm3 LSM3;MDS017 P62310 ENST00000306024 K04796 1 0.98348 2.2627 0.77677 1.3206 1.4461 0.96143 FERM_M;FERM_N;I_LWEQ;Talin_middle;VBS actin cytoskeleton;adherens junction;cell junction;cell projection;cell-cell junction;cell-substrate adherens junction;cell-substrate junction;cytoplasm;cytoskeleton;focal adhesion;intracellular organelle;non-membrane-bounded organelle;organelle;ruffle actin binding;binding;cytoskeletal protein binding;protein binding;structural constituent of cytoskeleton;structural molecule activity anatomical structure formation;cell adhesion;cell-cell junction assembly;cellular component assembly;cellular component organization;cellular process;cytoskeletal anchoring at plasma membrane;cytoskeleton organization;organelle organization Focal adhesion 15 8 8 8 4.3 4.3 271.61 1.0251E-206 224850000 118900000 105950000 3477 IPI:IPI00219299.4 Talin-2 TLN2;KIAA0320 Q9Y4G6 ENST00000306829 K06271 1 0.21115 0.50618 NaN 0.26413 0.35858 NaN Pkinase acrosomal vesicle;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;membrane-bounded vesicle;nucleus;organelle;secretory granule;vesicle ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;protein tyrosine kinase activity;purine nucleoside binding;transferase activity cellular biopolymer metabolic process;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process 4 4 4 7.8 7.8 7.8 73.514 3.5961E-93 7488400 4737300 2751100 3479 IPI:IPI00847415.1;IPI:IPI00298896.8;IPI:IPI00219341.1 Dual specificity protein kinase CLK3;CDC-like kinase 3 CLK3 P49761-4;P49761;P49761-1;P49761-3 ENST00000330804;ENST00000345005;ENST00000348245;ENST00000352989;ENST00000395066 K08823 3 0.73878 1.4951 0.79956 1.0037 0.95748 1.0506 efhand actin binding;binding;calcium ion binding;cation binding;cytoskeletal protein binding;ion binding;metal ion binding;protein binding 6 6 6 35.2 35.2 35.2 22.313 1.6529E-31 142580000 79761000 62818000 3480 IPI:IPI00219344.4;IPI:IPI00219103.6;IPI:IPI00395510.5 Hippocalcin-like protein 1;Visinin-like protein 3;Calcium-binding protein BDR-1;HLP2;Neuron-specific calcium-binding protein hippocalcin;Calcium-binding protein BDR-2 HPCAL1;BDR1;HPCA;BDR2 P37235;P84074 ENST00000307845;ENST00000381765;ENST00000373467 3 NaN 0.7944 0.63637 NaN 0.55165 0.80597 CBS;PALP cell part;cytoplasmic part;cytosol;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;carbon-oxygen lyase activity;catalytic activity;cation binding;cystathionine beta-synthase activity;hydro-lyase activity;ion binding;iron ion binding;lipid binding;lyase activity;pyridoxal phosphate binding;steroid binding;vitamin binding cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;cysteine metabolic process;organic acid metabolic process;sulfur amino acid biosynthetic process;sulfur amino acid metabolic process Glycine, serine and threonine metabolism;Methionine metabolism;Selenoamino acid metabolism 5 5 5 12.7 12.7 12.7 61.862 2.1955E-105 17659000 9772200 7886700 3481 IPI:IPI00219649.4;IPI:IPI00219352.4 Cystathionine beta-synthase;Serine sulfhydrase;Beta-thionase CBS P35520-2;P35520;P35520-1 ENST00000352178;ENST00000359624;ENST00000398158;ENST00000398165;ENST00000398168 K01697 2 0.77387 1.1937 0.67976 1.0029 0.81577 0.82806 PMI_typeI cell part;cytoplasm;intracellular part binding;catalytic activity;cation binding;intramolecular oxidoreductase activity;intramolecular oxidoreductase activity, interconverting aldoses and ketoses;ion binding;isomerase activity;mannose-6-phosphate isomerase activity;zinc ion binding carbohydrate metabolic process;metabolic process;primary metabolic process Fructose and mannose metabolism 5 5 5 18 18 18 46.655 1.5965E-78 17652000 9313500 8338500 3482 IPI:IPI00219358.7;IPI:IPI00332187.7 Mannose-6-phosphate isomerase;Phosphomannose isomerase;Phosphohexomutase MPI;PMI1 P34949-1;P34949;P34949-2 ENST00000323744;ENST00000352410 K01809 2 0.83253 1.5432 0.82811 1.0887 1.0322 1.0685 ERM;FERM_C;FERM_M;FERM_N apical plasma membrane;cell projection;cell projection membrane;cytoplasm;cytoskeleton;extrinsic to membrane;filopodium;intracellular non-membrane-bounded organelle;intracellular organelle;microvillus membrane;non-membrane-bounded organelle;organelle binding;cell adhesion molecule binding;cytoskeletal protein binding;protein binding;receptor binding;structural constituent of cytoskeleton;structural molecule activity biological adhesion;cell adhesion;cell migration;cell motility;cell motion;cell-cell adhesion;cellular process;immune system process;leukocyte adhesion;leukocyte migration;membrane docking;membrane to membrane docking Leukocyte transendothelial migration;Regulation of actin cytoskeleton 47 47 34 71.6 71.6 54.8 67.819 0 15325000000 8080100000 7245000000 3483 IPI:IPI00219365.3 Moesin;Membrane-organizing extension spike protein MSN P26038 ENST00000360270 K05763 1 0.86077 1.5278 0.76675 1.1459 1.0698 0.98315 L51_S25_CI-B8 cytoplasmic part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;mitochondrial membrane part;mitochondrial part;mitochondrial respiratory chain complex I;NADH dehydrogenase complex;organelle part;protein complex catalytic activity;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor cellular metabolic process;cellular process;electron transport chain;generation of precursor metabolites and energy;metabolic process;mitochondrial electron transport, NADH to ubiquinone;respiratory electron transport chain;transport Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 4 4 4 54.5 54.5 54.5 10.921 3.7856E-70 104940000 54575000 50363000 3484 IPI:IPI00219381.5 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2;NADH-ubiquinone oxidoreductase B8 subunit;Complex I-B8 NDUFA2 O43678 ENST00000252102 K03946 1 0.77465 1.5951 0.82937 1.0364 1.0445 1.0775 NDUF_B12 cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;macromolecular complex;membrane part;mitochondrial part;mitochondrial respiratory chain complex I;NADH dehydrogenase complex;organelle part;protein complex catalytic activity;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor cellular metabolic process;cellular process;electron transport chain;generation of precursor metabolites and energy;metabolic process;mitochondrial electron transport, NADH to ubiquinone;respiratory electron transport chain;transport Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 4 4 4 29.6 29.6 29.6 11.402 2.4476E-06 120200000 64883000 55318000 3485 IPI:IPI00219383.3 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3;NADH-ubiquinone oxidoreductase B12 subunit;Complex I-B12 NDUFB3 O43676 ENST00000237889 K03959 1 0.68918 1.7463 0.66308 0.95578 1.0704 0.92747 NDUF_B6 cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;macromolecular complex;membrane part;mitochondrial part;mitochondrial respiratory chain complex I;NADH dehydrogenase complex;organelle part;protein complex catalytic activity;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor cellular metabolic process;cellular process;electron transport chain;generation of precursor metabolites and energy;metabolic process;mitochondrial electron transport, NADH to ubiquinone;respiratory electron transport chain;transport Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 4 4 4 45.3 45.3 45.3 15.489 4.4702E-33 119410000 65390000 54025000 3486 IPI:IPI00219385.3 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6;NADH-ubiquinone oxidoreductase B17 subunit;Complex I-B17 NDUFB6 O95139 ENST00000379847 K03962 1 0.69622 1.5508 0.72085 0.92391 1.0073 0.95645 SMC_hinge;SMC_N basement membrane;chromosomal part;cohesin complex;cytoplasm;cytoskeletal part;extracellular matrix part;extracellular region part;intracellular part;macromolecular complex;nuclear matrix;nuclear part;organelle part;protein complex;spindle pole ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;microtubule motor activity;motor activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity DNA metabolic process;DNA repair;microtubule cytoskeleton organization;nitrogen compound metabolic process;nuclear division;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to DNA damage stimulus;response to stress Cell cycle - yeast 35 35 35 33.4 33.4 33.4 141.54 0 754040000 409790000 344250000 3487 IPI:IPI00219420.3 Structural maintenance of chromosomes protein 3;Chondroitin sulfate proteoglycan 6;Chromosome-associated polypeptide;Basement membrane-associated chondroitin proteoglycan SMC3;BAM;BMH;CSPG6;SMC3L1 Q9UQE7 ENST00000361804 K06669 1 0.73728 1.3256 NaN 0.90968 0.92763 NaN cell part;intracellular organelle part;intracellular part;macromolecular complex;mediator complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;protein binding;receptor activity;receptor binding;RNA polymerase II transcription factor activity;signal transducer activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding cell communication;cellular process;intracellular signaling cascade;regulation of biosynthetic process;regulation of transcription, DNA-dependent;signal transduction;transcription initiation;transcription initiation from RNA polymerase II promoter 3 3 3 3.6 3.6 3.6 110.3 2.82E-15 13749000 7668300 6080600 3488 IPI:IPI00219430.10 Mediator of RNA polymerase II transcription subunit 24;Mediator complex subunit 24;Thyroid hormone receptor-associated protein complex 100 kDa component;Thyroid hormone receptor-associated protein 4;Vitamin D3 receptor-interacting protein complex component DRIP100;Activator-recruited cofactor 100 kDa component;Cofactor required for Sp1 transcriptional activation subunit 4;CRSP complex subunit 4 MED24;ARC100;CRSP4;DRIP100;KIAA0130;THRAP4;TRAP100 O75448 ENST00000356271;ENST00000394126;ENST00000394128 1 0.81053 1.8561 0.71047 1.0822 1.1679 0.98097 Peptidase_S24 cell fraction;endoplasmic reticulum membrane;insoluble fraction;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane fraction;membrane part;microsome;organelle membrane;organelle part;vesicular fraction catalytic activity;hydrolase activity;peptidase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;peptide metabolic process;protein catabolic process;protein metabolic process;protein processing;proteolysis;signal peptide processing Protein export 7 7 7 28.6 28.6 28.6 21.542 1.832E-113 78043000 42748000 35295000 3489 IPI:IPI00219436.3 Signal peptidase complex catalytic subunit SEC11C;SEC11 homolog C;SEC11-like protein 3;Microsomal signal peptidase 21 kDa subunit;SPC21 SEC11C;SEC11L3;SPC21;SPCS4C Q9BY50 ENST00000299714 K03100 1 0.8066 1.5093 0.82539 1.0505 0.9936 1.118 PBP cell part;cytoplasm;intracellular part ATP binding;binding;endopeptidase inhibitor activity;enzyme inhibitor activity;lipid binding;nucleoside binding;nucleotide binding;phospholipid binding;protein binding;purine nucleoside binding;serine-type endopeptidase inhibitor activity 14 14 14 84.5 84.5 84.5 21.057 0 2596100000 1360000000 1236100000 3490 IPI:IPI00219446.5 Phosphatidylethanolamine-binding protein 1;Prostatic-binding protein;HCNPpp;Neuropolypeptide h3;Raf kinase inhibitor protein;Hippocampal cholinergic neurostimulating peptide PEBP1;PBP;PEBP P30086 ENST00000261313 1 0.87592 1.7515 0.8905 1.1217 1.1469 1.129 4HBT cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle acyl-CoA binding;acyl-CoA thioesterase activity;binding;carboxylesterase activity;catalytic activity;CoA hydrolase activity;fatty acid binding;hydrolase activity;hydrolase activity, acting on ester bonds;lipid binding;palmitoyl-CoA hydrolase activity lipid metabolic process;metabolic process;primary metabolic process Biosynthesis of unsaturated fatty acids 15 15 7 41.6 41.6 14.9 36.567 0 2789400000 1475400000 1314000000 3491 IPI:IPI00219452.1;IPI:IPI00010415.2;IPI:IPI00395748.2;IPI:IPI00219451.1 Cytosolic acyl coenzyme A thioester hydrolase;Long chain acyl-CoA thioester hydrolase;Acyl-CoA thioesterase 7;CTE-IIa;Brain acyl-CoA hydrolase ACOT7;BACH O00154-6;O00154;O00154-1;O00154-4;O00154-5 ENST00000361521;ENST00000377842;ENST00000377845;ENST00000377855;ENST00000377858;ENST00000377860 K01068 4 0.83027 1.3657 0.87863 1.0598 0.88412 1.0936 Profilin actin cytoskeleton;cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle actin binding;binding;cytoskeletal protein binding;lipid binding;phosphatidylinositol-4,5-bisphosphate binding;phosphoinositide binding;phospholipid binding;protein binding actin cytoskeleton organization;actin filament-based process;cellular component organization;cellular process;cytoskeleton organization;organelle organization;regulation of actin polymerization or depolymerization;regulation of metabolic process Regulation of actin cytoskeleton 3 3 3 26.4 26.4 26.4 15.046 5.3746E-78 225950000 119990000 105960000 3492 IPI:IPI00219468.4;IPI:IPI00940567.1 Profilin-2;Profilin II PFN2 P35080-1;P35080;P35080-2 ENST00000239940 K05759 2 1.6738 NaN NaN 2.472 NaN NaN Serpin extracellular region endopeptidase inhibitor activity;enzyme inhibitor activity;enzyme regulator activity;peptidase inhibitor activity;serine-type endopeptidase inhibitor activity 4 4 4 9.2 9.2 9.2 47.174 0.00053007 6909000 3468500 3440500 3493 IPI:IPI00219476.1 Serpin A12;Visceral adipose tissue-derived serine protease inhibitor;Visceral adipose-specific serpin;OL-64 SERPINA12 Q8IW75 ENST00000341228 1 0.72859 1.4452 0.71157 0.93296 0.93853 0.93666 Peptidase_C12 cell part;cytoplasmic part;cytosol;intracellular part;macromolecular complex;protein complex binding;catalytic activity;cysteine-type peptidase activity;hydrolase activity;hydrolase activity, acting on ester bonds;peptidase activity;protein binding;thiolester hydrolase activity;ubiquitin thiolesterase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process 14 14 14 46.8 46.8 46.8 37.606 8.6974E-129 812830000 441670000 371150000 3494 IPI:IPI00299313.2;IPI:IPI00219513.4;IPI:IPI00549820.4;IPI:IPI00219512.2 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin thioesterase L5;Ubiquitin C-terminal hydrolase UCH37 UCHL5;UCH37;AD-019;CGI-70 Q9Y5K5-1;Q9Y5K5;Q9Y5K5-3;Q9Y5K5-4;Q9Y5K5-2 ENST00000367451;ENST00000367455 K05610 4 0.80485 1.8442 0.87237 1.0825 1.1727 1.1642 Arf cell part;cytoplasmic part;Golgi apparatus part;Golgi membrane;intracellular organelle part;intracellular part;membrane;organelle membrane;organelle part binding;catalytic activity;enzyme activator activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity biological regulation;cell communication;cellular process;intracellular signaling cascade;regulation of biological process;regulation of cellular process;signal transduction;small GTPase mediated signal transduction 6 6 6 33.7 33.7 33.7 20.417 8.6664E-104 120760000 65429000 55326000 3495 IPI:IPI00219518.7;IPI:IPI00376097.6 ADP-ribosylation factor-like protein 1 ARL1 P40616 ENST00000261636 K07942 2 0.74492 1.6297 0.78296 0.98004 1.0591 1.0521 6PGD;NAD_binding_2 binding;catalytic activity;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;phosphogluconate dehydrogenase (decarboxylating) activity;protein binding alcohol metabolic process;carbohydrate metabolic process;metabolic process;monosaccharide metabolic process;oxidation reduction;pentose metabolic process;pentose-phosphate shunt, oxidative branch;primary metabolic process Glutathione metabolism;Pentose phosphate pathway 28 28 28 58.8 58.8 58.8 53.139 0 4521200000 2396000000 2125100000 3496 IPI:IPI00219525.10 6-phosphogluconate dehydrogenase, decarboxylating PGD;PGDH P52209 ENST00000270776;ENST00000377062 K00033 1 0.75481 1.5234 0.74071 0.97542 0.98424 0.98963 PGM_PMM_I;PGM_PMM_II;PGM_PMM_III;PGM_PMM_IV cell part;cytoplasmic part;cytosol;intracellular part binding;catalytic activity;cation binding;intramolecular transferase activity;intramolecular transferase activity, phosphotransferases;ion binding;isomerase activity;magnesium ion binding;metal ion binding;phosphoglucomutase activity alcohol metabolic process;carbohydrate metabolic process;glucose metabolic process;hexose metabolic process;metabolic process;monosaccharide metabolic process;primary metabolic process Galactose metabolism;Glycolysis / Gluconeogenesis;Pentose phosphate pathway;Starch and sucrose metabolism;Streptomycin biosynthesis 20 20 20 44.1 44.1 44.1 61.448 5.2234E-256 634590000 352840000 281750000 3497 IPI:IPI00219526.6;IPI:IPI00217872.3 Phosphoglucomutase-1;Glucose phosphomutase 1 PGM1 P36871-1;P36871;P36871-2 ENST00000371083;ENST00000371084 K01835 2 0.58677 1.2297 0.54978 0.82054 0.75464 0.79248 SPRY;zf-B_box;zf-C3HC4 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;cation binding;ion binding;ligase activity;metal ion binding;protein binding;transition metal ion binding;zinc ion binding catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 2 2 2 4.5 4.5 4.5 52.774 2.3303E-05 8637500 5257600 3379900 3498 IPI:IPI00219527.4;IPI:IPI00385975.1 Tripartite motif-containing protein 11;RING finger protein 92;Protein BIA1 TRIM11;RNF92 Q96F44-1;Q96F44;Q96F44-2 ENST00000284551 K10650 2 0.75652 NaN 0.62129 1.0172 NaN 0.87793 efhand_1;efhand_2;ZZ cell junction;cell part;cytoplasm;intracellular part;membrane part;plasma membrane part;synapse binding;calcium ion binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding cell communication;cell-cell signaling;cellular process;multicellular organismal process;muscle contraction;muscle system process;neuromuscular synaptic transmission;signal transduction;striated muscle contraction;synaptic transmission;system process 2 2 2 3.5 3.5 3.5 71.355 0.0013401 4620300 2618900 2001400 3499 IPI:IPI00299362.6;IPI:IPI00373897.4;IPI:IPI00219529.1;IPI:IPI00219530.1;IPI:IPI00942739.1;IPI:IPI00929645.1;IPI:IPI00749235.3;IPI:IPI00218653.2;IPI:IPI00296091.2;IPI:IPI00177936.4;IPI:IPI00218655.1 Dystrobrevin beta;Beta-dystrobrevin;Dystrobrevin alpha;Dystrobrevin-alpha;Dystrophin-related protein 3 DTNB;DTNA;DRP3 O60941-1;O60941;O60941-4;O60941-2;O60941-3;Q9Y4J8-1;Q9Y4J8;Q9Y4J8-2;Q9Y4J8-3;Q9Y4J8-4;Q9Y4J8-5;Q9Y4J8-6;Q9Y4J8-8 ENST00000303659;ENST00000406818;ENST00000269191;ENST00000269192;ENST00000283365;ENST00000348997;ENST00000399097;ENST00000399111;ENST00000399113;ENST00000399121 11 0.73561 1.6159 0.72219 0.97357 1.0417 0.99443 ELMO_CED12 cell part;cytoplasmic part;cytoskeleton;cytosol;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane;non-membrane-bounded organelle;organelle;plasma membrane binding;protein binding;protein domain specific binding;SH3 domain binding apoptosis;cell communication;cell death;cell motion;cytoskeleton organization;intracellular signaling cascade;organelle organization;phagocytosis, engulfment;Ras protein signal transduction;signal transduction;small GTPase mediated signal transduction Chemokine signaling pathway 25 25 25 38.7 38.7 38.7 83.829 1.2036E-247 1122400000 597840000 524540000 3500 IPI:IPI00219532.1;IPI:IPI00745455.2;IPI:IPI00940537.1 Engulfment and cell motility protein 1;CED-12 homolog ELMO1;KIAA0281 Q92556-1;Q92556 ENST00000310758;ENST00000341056;ENST00000361912;ENST00000396040;ENST00000396042 K12366 3 1.2815 1.6084 1.8688 1.7696 1.0472 2.3205 DNA_pol_lambd_f cell part;cytoplasm;cytoskeletal part;intracellular organelle part;intracellular part;microtubule;nuclear part;nucleoplasm;organelle part;spindle microtubule binding;catalytic activity;cytoskeletal protein binding;DNA-directed DNA polymerase activity;magnesium ion binding;microtubule binding;protein binding;transferase activity;transferase activity, transferring phosphorus-containing groups;tubulin binding base-excision repair;DNA metabolic process;DNA repair;DNA replication;DNA-dependent DNA replication;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to stress Base excision repair 4 4 4 10.1 10.1 10.1 38.177 4.849E-43 3324900000 1367100000 1957800000 3501 IPI:IPI00219538.3 DNA polymerase beta POLB P06746 ENST00000265421 K02330 1 0.67836 1.5657 0.70227 0.92489 0.96235 0.9432 Peptidase_C1_2 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle aminopeptidase activity;carboxypeptidase activity;catalytic activity;cysteine-type endopeptidase activity;cysteine-type peptidase activity;endopeptidase activity;exopeptidase activity;hydrolase activity;peptidase activity biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis 14 14 14 43.1 43.1 43.1 52.562 2.2292E-201 1253200000 571970000 681280000 3502 IPI:IPI00219575.5 Bleomycin hydrolase BLMH Q13867 ENST00000261714;ENST00000394819 K01372 1 0.33567 1.5075 0.57817 0.50984 0.89977 0.785 Pkinase catalytic activity;MAP kinase kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;protein serine/threonine/tyrosine kinase activity;purine nucleoside binding behavior;cell communication;cell motion;cellular process;chemotaxis;intracellular signaling cascade;locomotion;locomotory behavior;Ras protein signal transduction;response to external stimulus;signal transduction;small GTPase mediated signal transduction Acute myeloid leukemia;B cell receptor signaling pathway;Bladder cancer;Chemokine signaling pathway;Chronic myeloid leukemia;Colorectal cancer;Dorso-ventral axis formation;Endometrial cancer;ErbB signaling pathway;Fc epsilon RI signaling pathway;Focal adhesion;Gap junction;Glioma;GnRH signaling pathway;Insulin signaling pathway;Long-term depression;Long-term potentiation;MAPK signaling pathway;MAPK signaling pathway - fly;Melanogenesis;Melanoma;Natural killer cell mediated cytotoxicity;Non-small cell lung cancer;Pancreatic cancer;Pathways in cancer;Progesterone-mediated oocyte maturation;Prostate cancer;Regulation of actin cytoskeleton;Renal cell carcinoma;T cell receptor signaling pathway;Thyroid cancer;Toll-like receptor signaling pathway;Vascular smooth muscle contraction;VEGF signaling pathway 20 11 11 42.2 23.7 23.7 43.439 8.6859E-213 276770000 155640000 121130000 3503 IPI:IPI00219604.3 Dual specificity mitogen-activated protein kinase kinase 1;ERK activator kinase 1;MAPK/ERK kinase 1 MAP2K1;MEK1;PRKMK1 Q02750 ENST00000307102 K04368 1 0.6955 1.4079 0.70264 0.91525 0.92079 0.93872 Pribosyltran cell part;cytoplasmic part;cytosol;intracellular part ATP binding;binding;catalytic activity;kinase activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;ribose phosphate diphosphokinase activity;transferase activity nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;purine base metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;system process Pentose phosphate pathway;Purine metabolism 18 18 7 58.8 58.8 22.3 34.834 2.0564E-281 2088200000 1120700000 967470000 3504 IPI:IPI00219616.7 Ribose-phosphate pyrophosphokinase 1;Phosphoribosyl pyrophosphate synthetase I;PPRibP PRPS1 P60891 ENST00000372435 K00948 1 0.62149 1.2555 0.6042 0.81514 0.79846 0.84026 Pribosyltran ATP binding;binding;catalytic activity;kinase activity;magnesium ion binding;nucleoside binding;nucleotide binding;purine nucleoside binding;ribose phosphate diphosphokinase activity;transferase activity biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside metabolic process;nucleoside phosphate metabolic process;nucleotide metabolic process Pentose phosphate pathway;Purine metabolism 17 8 6 56.7 28 23.7 35.054 0 430710000 232780000 197940000 3505 IPI:IPI00718888.1;IPI:IPI00219617.5 Ribose-phosphate pyrophosphokinase 2;Phosphoribosyl pyrophosphate synthetase II;PPRibP PRPS2 P11908-2;P11908;P11908-1 ENST00000380668;ENST00000398491 K00948 2 0.85785 1.6195 0.82137 1.1265 1.1241 1.073 Proteasome;Proteasome_A_N cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;proteasome core complex;protein complex binding;catalytic activity;endopeptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides;protein binding;threonine-type endopeptidase activity;threonine-type peptidase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Proteasome 12 12 12 62.8 62.8 62.8 25.898 0 1151400000 598990000 552410000 3506 IPI:IPI00219622.3 Proteasome subunit alpha type-2;Proteasome component C3;Macropain subunit C3;Multicatalytic endopeptidase complex subunit C3 PSMA2;PSC3 P25787 ENST00000223321 K02726 1 1.187 1.7891 1.5774 1.5747 1.1616 1.9482 Carb_anhydrase binding;carbonate dehydratase activity;carbon-oxygen lyase activity;catalytic activity;cation binding;hydro-lyase activity;ion binding;lyase activity;metal ion binding;transition metal ion binding;zinc ion binding cellular metabolic process;cellular process;metabolic process;one-carbon metabolic process Nitrogen metabolism 6 6 6 27.9 27.9 27.9 32.973 1.4235E-44 134550000 64391000 70156000 3507 IPI:IPI00219669.5 Carbonic anhydrase-related protein;Carbonic anhydrase VIII CA8;CALS P35219 ENST00000317995 K01672 1 0.75981 1.8009 0.74791 1.0386 1.0996 1.0239 DSBA cytoplasmic part;external encapsulating structure part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;microbody;organelle;outer membrane-bounded periplasmic space;periplasmic space;peroxisome binding;catalytic activity;disulfide oxidoreductase activity;glutathione transferase activity;oxidoreductase activity;oxidoreductase activity, acting on sulfur group of donors;protein binding;protein disulfide oxidoreductase activity;transferase activity Drug metabolism - cytochrome P450;Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450 7 7 7 38.5 38.5 38.5 25.497 8.4522E-143 506030000 281240000 224790000 3508 IPI:IPI00219673.6 Glutathione S-transferase kappa 1;Glutathione S-transferase subunit 13;GST 13-13;GST class-kappa;GSTK1-1 GSTK1;HDCMD47P Q9Y2Q3 ENST00000358406;ENST00000378173 K00799 1 0.59151 1.39 0.56818 0.81847 0.9361 0.72338 DeoC cell part;cytoplasm;intracellular part aldehyde-lyase activity;binding;carbon-carbon lyase activity;catalytic activity;deoxyribose-phosphate aldolase activity;lyase activity;protein binding catabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside metabolic process;nucleoside phosphate metabolic process;nucleotide metabolic process Pentose phosphate pathway 10 10 10 40.3 40.3 40.3 35.23 8.5519E-152 105790000 58305000 47484000 3509 IPI:IPI00219677.4 Putative deoxyribose-phosphate aldolase;Phosphodeoxyriboaldolase DERA;CGI-26 Q9Y315 ENST00000025429 K01619 1 0.6477 1.3386 0.67133 0.89344 0.88477 0.89903 EIF_2_alpha;S1 cell part;cytoplasmic part;cytosol;eukaryotic translation initiation factor 2 complex;intracellular part;macromolecular complex;polysome;protein complex;ribonucleoprotein complex binding;nucleic acid binding;protein binding;RNA binding;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 27 27 27 69.8 69.8 69.8 36.112 0 2861000000 1406600000 1454400000 3510 IPI:IPI00219678.3 Eukaryotic translation initiation factor 2 subunit 1;Eukaryotic translation initiation factor 2 subunit alpha EIF2S1;EIF2A P05198 ENST00000256383 K03237 1 0.74806 1.2188 0.64644 0.98391 0.88017 0.85509 Band_7 cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;cytoskeleton;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;melanosome;membrane-bounded organelle;membrane-bounded vesicle;organelle;vesicle binding;protein binding anatomical structure formation;cellular component assembly;cellular component organization;macromolecular complex assembly;macromolecular complex subunit organization;protein complex assembly;protein homooligomerization;protein oligomerization 3 3 3 12.5 12.5 12.5 31.73 9.9493E-48 53782000 27164000 26619000 3511 IPI:IPI00219682.6 Erythrocyte band 7 integral membrane protein;Stomatin;Protein 7.2b STOM;BND7;EPB72 P27105 ENST00000286713 1 NaN 3.2589 NaN NaN 2.0513 NaN zf-C2H2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;RNA polymerase II transcription factor activity;transcription regulator activity;transition metal ion binding;zinc ion binding biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent 3 3 3 20.1 20.1 20.1 31.18 1.8699E-07 1502900 1095400 407430 3512 IPI:IPI00219691.2 Krueppel-like factor 13;Transcription factor BTEB3;Basic transcription element-binding protein 3;RANTES factor of late activated T-lymphocytes 1;Transcription factor NSLP1;Novel Sp1-like zinc finger transcription factor 1 KLF13;BTEB3;NSLP1 Q9Y2Y9 ENST00000307145 K09208 1 0.70353 1.5209 0.70302 0.95651 0.98265 0.96013 Mito_carr integral to membrane;integral to plasma membrane;intracellular part;intrinsic to membrane;intrinsic to plasma membrane;membrane;membrane part;mitochondrial inner membrane;mitochondrial membrane;organelle inner membrane;organelle membrane;organelle part anion transmembrane transporter activity;anion:anion antiporter activity;antiporter activity;binding;ion transmembrane transporter activity;secondary active transmembrane transporter activity;solute:solute antiporter activity;transporter activity establishment of localization;transport 12 12 12 40.8 40.8 40.8 34.061 1.1049E-240 907620000 490400000 417220000 3513 IPI:IPI00219729.3 Mitochondrial 2-oxoglutarate/malate carrier protein;Solute carrier family 25 member 11 SLC25A11;SLC20A4 Q02978 ENST00000225665 1 0.82792 1.6525 0.85587 1.1218 1.0544 1.1344 GST_C;GST_N cell part;cytoplasm;intracellular part binding;catalytic activity;glutathione transferase activity;protein binding;transferase activity;transferase activity, transferring alkyl or aryl (other than methyl) groups anti-apoptosis;central nervous system development;developmental process;metabolic process;negative regulation of apoptosis;negative regulation of programmed cell death;regulation of apoptosis;regulation of cell death;regulation of programmed cell death Drug metabolism - cytochrome P450;Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450 16 16 16 71 71 71 23.356 0 8413300000 4420100000 3993200000 3514 IPI:IPI00219757.13 Glutathione S-transferase P;GST class-pi;GSTP1-1 GSTP1;FAEES3;GST3 P09211 ENST00000196968;ENST00000398606 K00799 1 0.69505 2.1923 0.74831 0.93246 1.4104 1.0006 NDUF_B7 cytoplasmic part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;mitochondrial membrane part;mitochondrial part;mitochondrial respiratory chain complex I;NADH dehydrogenase complex;organelle part;protein complex catalytic activity;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor cellular metabolic process;cellular process;electron transport chain;generation of precursor metabolites and energy;metabolic process;mitochondrial electron transport, NADH to ubiquinone;respiratory electron transport chain;transport Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 2 2 2 17.5 17.5 17.5 16.402 9.0598E-09 41252000 21246000 20007000 3515 IPI:IPI00219772.3 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7;NADH-ubiquinone oxidoreductase B18 subunit;Complex I-B18;Cell adhesion protein SQM1 NDUFB7 P17568 ENST00000215565 K03963 1 0.92935 1.5831 0.84613 1.1572 1.0366 1.13 cNMP_binding;RIIa cAMP-dependent protein kinase complex;cell fraction;cell part;cytoplasm;insoluble fraction;intracellular part;macromolecular complex;membrane;membrane fraction;plasma membrane;protein complex AMP binding;binding;cAMP-dependent protein kinase regulator activity;enzyme regulator activity;kinase regulator activity;nucleoside binding;nucleotide binding;protein kinase regulator activity;purine nucleoside binding;purine nucleotide binding cell communication;cellular process;hormone-mediated signaling;intracellular signaling cascade;regulation of protein amino acid phosphorylation;response to endogenous stimulus;response to hormone stimulus;response to organic substance;signal transduction Apoptosis;Insulin signaling pathway 14 14 10 42.6 42.6 32.4 45.518 7.8465E-107 241450000 123020000 118430000 3516 IPI:IPI00219774.3 cAMP-dependent protein kinase type II-alpha regulatory subunit PRKAR2A;PKR2;PRKAR2 P13861 ENST00000265563 K04739 1 0.94095 1.5274 0.82962 1.2109 1.0176 1.0611 UQ_con acid-amino acid ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleoside binding;nucleotide binding;purine nucleoside binding;ubiquitin-protein ligase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;protein metabolic process;protein modification process;proteolysis;regulation of metabolic process;ubiquitin-dependent protein catabolic process Parkinson's disease;Ubiquitin mediated proteolysis 3 3 3 13.5 13.5 13.5 19.509 1.1169E-07 53463000 28074000 25389000 3517 IPI:IPI00219783.7 Ubiquitin-conjugating enzyme E2 G1;Ubiquitin-protein ligase G1;Ubiquitin carrier protein G1;E217K;UBC7 UBE2G1;UBE2G P62253 ENST00000254724;ENST00000396981 K10575 1 0.70307 1.1532 0.71354 0.84235 0.8426 0.93121 Brix cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;protein binding cellular biopolymer metabolic process;cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 5 5 5 11.2 11.2 11.2 53.193 3.4431E-146 179970000 92730000 87240000 3518 IPI:IPI00329590.4;IPI:IPI00219793.1 Suppressor of SWI4 1 homolog;Peter Pan homolog PPAN;SSF1 Q9NQ55-1;Q9NQ55;Q9NQ55-2 ENST00000253107;ENST00000342696 2 NaN 5.676 0.1914 NaN 3.5433 0.27464 S_100 adherens junction;cell junction;cell-substrate adherens junction;cell-substrate junction;cytosol;endoplasmic reticulum;extracellular region;focal adhesion;intracellular organelle;membrane-bounded organelle;nucleus;organelle binding;calcium ion binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding angiogenesis;defense response;epidermis development;immune response;immune system process;response to bacterium;response to biotic stimulus;response to oxidative stress;response to reactive oxygen species;response to stress;tissue development 6 6 6 35.6 35.6 35.6 11.471 1.0562E-36 23135000 22503000 632610 3519 IPI:IPI00219806.7;IPI:IPI00328396.3 Protein S100-A7;S100 calcium-binding protein A7;Psoriasin S100A7;PSOR1;S100A7C P31151 ENST00000368722;ENST00000368723 2 0.8959 1.8372 0.82546 1.2473 1.1183 1.0537 Pkinase cell part;cytoplasm;intracellular part ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cell communication;cell surface receptor linked signal transduction;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;signal transduction Hedgehog signaling pathway 2 2 1 4.3 4.3 2.1 48.511 0.00024121 13778000 7184800 6592800 3520 IPI:IPI00465058.2;IPI:IPI00219823.1 Casein kinase I isoform gamma-1 CSNK1G1 Q9HCP0-1;Q9HCP0;Q9HCP0-2 ENST00000303032;ENST00000303052 K08958 2 0.72658 1.2768 0.84462 0.90101 0.90512 1.0346 Clat_adaptor_s AP-2 adaptor complex;AP-type membrane coat adaptor complex;clathrin adaptor complex;cytoplasmic part;cytoplasmic vesicle part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;membrane part;organelle part;protein complex binding;protein binding;protein transporter activity;substrate-specific transporter activity;transporter activity cellular process;intracellular protein transport;organelle organization;protein complex assembly;regulation of immune effector process;regulation of immune system process;regulation of response to biotic stimulus;transport;vesicle coating Huntington's disease 5 5 5 31.7 31.7 31.7 17.018 2.6491E-07 129240000 67279000 61963000 3521 IPI:IPI00219840.4;IPI:IPI00183781.4 AP-2 complex subunit sigma-1;Adapter-related protein complex 2 sigma-1 subunit;Sigma2-adaptin;Plasma membrane adaptor AP-2 17 kDa protein;HA2 17 kDa subunit;Clathrin assembly protein 2 small chain;Clathrin coat assembly protein AP17;Clathrin coat-associated protein AP17 AP2S1;AP17;CLAPS2 P53680-1;P53680;P53680-2 ENST00000263270;ENST00000352203 K11827 2 0.61662 1.1521 0.63329 0.84887 0.77467 0.84609 DNA_ligase_A_C;DNA_ligase_A_M;DNA_ligase_A_N cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part ATP binding;binding;catalytic activity;DNA binding;DNA ligase (ATP) activity;DNA ligase activity;ligase activity;magnesium ion binding;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding biosynthetic process;cell cycle;DNA metabolic process;DNA recombination;DNA replication;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleotide-excision repair, DNA gap filling Base excision repair;DNA replication;Mismatch repair;Nucleotide excision repair 21 21 21 29.7 29.7 29.7 101.73 8.5736E-302 649810000 346780000 303030000 3522 IPI:IPI00219841.6 DNA ligase 1;DNA ligase I;Polydeoxyribonucleotide synthase [ATP] 1 LIG1 P18858 ENST00000263274 K10747 1 0.82607 1.4985 0.83789 1.0994 1.0141 1.1379 LMWPc cell fraction;cell part;cytoplasm;intracellular part;soluble fraction acid phosphatase activity;binding;catalytic activity;hydrolase activity;non-membrane spanning protein tyrosine phosphatase activity;phosphoprotein phosphatase activity;protein binding;protein tyrosine phosphatase activity cellular biopolymer metabolic process;cellular process;dephosphorylation;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid dephosphorylation;protein metabolic process;protein modification process 9 9 9 55.1 55.1 55.1 18.042 6.1427E-118 1418400000 727750000 690690000 3523 IPI:IPI00219861.3;IPI:IPI00218847.5;IPI:IPI00410615.2 Low molecular weight phosphotyrosine protein phosphatase;Low molecular weight cytosolic acid phosphatase;Red cell acid phosphatase 1;Adipocyte acid phosphatase ACP1 P24666-1;P24666;P24666-2;P24666-3 ENST00000272065;ENST00000272067 3 0.89685 1.5621 0.87213 1.0602 1.1157 1.0962 LSM cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;ribonucleoprotein complex binding;nucleic acid binding;protein binding;RNA binding;snRNA binding;U6 snRNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 4 4 4 57.3 57.3 57.3 10.403 3.4668E-77 300810000 156350000 144460000 3524 IPI:IPI00219871.5 U6 snRNA-associated Sm-like protein LSm8 LSM8 O95777 ENST00000249299 1 0.76537 1.4428 0.74672 1 0.9564 0.98439 UCH cell part;cytoplasm;intracellular part catalytic activity;cysteine-type endopeptidase activity;endopeptidase activity;peptidase activity;RNA guanylyltransferase activity;tRNA guanylyltransferase activity;ubiquitin thiolesterase activity;ubiquitin-specific protease activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process 28 28 28 57.9 57.9 57.9 56.068 0 2197300000 1182000000 1015300000 3526 IPI:IPI00219913.10;IPI:REV_IPI00102581.3 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin thioesterase 14;Ubiquitin-specific-processing protease 14;Deubiquitinating enzyme 14 USP14;TGT P54578 ENST00000261601;ENST00000400267 K11843 2 0.62539 1.4765 NaN 0.81687 0.90618 NaN DMAP1 cell part;H4/H2A histone acetyltransferase complex;histone acetyltransferase complex;intracellular organelle part;intracellular part;macromolecular complex;NuA4 histone acetyltransferase complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;DNA binding;nucleic acid binding;protein binding;transcription regulator activity;transcription repressor activity chromatin organization;DNA alkylation;DNA metabolic process;DNA methylation;DNA modification;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein modification process;regulation of transcription, DNA-dependent;transcription 5 5 5 11.8 11.8 11.8 52.992 1.1623E-55 11986000 6571700 5413900 3527 IPI:IPI00219919.2 DNA methyltransferase 1-associated protein 1 DMAP1;KIAA1425 Q9NPF5 ENST00000315913;ENST00000361745;ENST00000372289 K11324 1 0.82448 1.4887 0.72226 1.03 1.043 0.99156 ADK cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;cytidylate kinase activity;kinase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups;uridine kinase activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;pyrimidine nucleotide biosynthetic process;pyrimidine nucleotide metabolic process 10 10 10 35.5 35.5 35.5 25.855 3.5532E-173 443730000 240310000 203430000 3528 IPI:IPI00219953.5 UMP-CMP kinase;Cytidylate kinase;Deoxycytidylate kinase;Cytidine monophosphate kinase;Uridine monophosphate kinase;Uridine monophosphate/cytidine monophosphate kinase CMPK1;CMK;CMPK;UCK;UMK;UMPK P30085 ENST00000371873 1 0.65268 1.2836 0.66067 0.88682 0.84476 0.9032 NUDIX cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;microbody;organelle;peroxisome binding;catalytic activity;hydrolase activity;intramolecular oxidoreductase activity;intramolecular oxidoreductase activity, transposing C=C bonds;ion binding;isomerase activity;isopentenyl-diphosphate delta-isomerase activity;magnesium ion binding alcohol metabolic process;cholesterol biosynthetic process;cholesterol metabolic process;isoprenoid metabolic process;lipid metabolic process;metabolic process;steroid biosynthetic process;steroid metabolic process;terpenoid metabolic process 11 11 11 48.9 48.9 48.9 32.485 5.0687E-71 369660000 197730000 171930000 3531 IPI:IPI00220014.2;IPI:IPI00645307.2 Isopentenyl-diphosphate Delta-isomerase 1;Isopentenyl pyrophosphate isomerase 1 IDI1 Q13907-2;Q13907;Q13907-1 ENST00000381344 2 0.77225 1.4433 0.74582 0.99383 0.98872 0.98504 ARS2 binding;protein binding response to arsenic;response to chemical stimulus;response to inorganic substance;response to stimulus 22 22 21 26.3 26.3 25.6 100.67 1.8695E-203 2716700000 1349500000 1367200000 3532 IPI:IPI00375144.5;IPI:IPI00888510.1;IPI:IPI00220038.1;IPI:IPI00888085.1;IPI:IPI00927582.2 Serrate RNA effector molecule homolog;Arsenite-resistance protein 2 SRRT;ARS2;ASR2 Q9BXP5-1;Q9BXP5;Q9BXP5-3;Q9BXP5-2;Q9BXP5-4;Q9BXP5-5 ENST00000347433 5 0.52924 1.0421 0.60725 0.7873 0.74402 0.81878 Sin_N cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle catalytic activity;DNA-directed RNA polymerase activity;nucleotidyltransferase activity;RNA polymerase activity;transferase activity;transferase activity, transferring phosphorus-containing groups biosynthetic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription 6 6 6 12.6 12.6 12.6 79.897 2.3936E-58 29235000 16056000 13179000 3533 IPI:IPI00220045.3;IPI:IPI00221314.4;IPI:IPI00018245.5 DNA-directed RNA polymerase III subunit RPC5;DNA-directed RNA polymerase III 80 kDa polypeptide POLR3E;KIAA1452 Q9NVU0-1;Q9NVU0;Q9NVU0-2;Q9NVU0-3 ENST00000299853;ENST00000359210 3 NaN 1.5998 0.70409 NaN 1.0211 0.94831 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding 3 3 3 3.6 3.6 3.6 100.03 2.8768E-11 4939800 2471600 2468200 3534 IPI:IPI00329602.1;IPI:IPI00220051.1 Cip1-interacting zinc finger protein;CDKN1A-interacting zinc finger protein 1;Nuclear protein NP94;Zinc finger protein 356 CIZ1;LSFR1;NP94;ZNF356 Q9ULV3-1;Q9ULV3;Q9ULV3-2 ENST00000325721;ENST00000372938;ENST00000393608 2 0.87348 4.4206 0.86536 1.0913 3.0509 1.0307 NDUF_B4 cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;macromolecular complex;membrane part;mitochondrial part;mitochondrial respiratory chain complex I;NADH dehydrogenase complex;organelle part;protein complex catalytic activity;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor cellular process;electron transport chain;generation of precursor metabolites and energy;metabolic process;mitochondrial electron transport, NADH to ubiquinone;respiratory electron transport chain;response to oxidative stress;response to stress;transport Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 3 3 3 26.4 26.4 26.4 15.208 1.3915E-18 53411000 27492000 25918000 3535 IPI:IPI00220059.5 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4;NADH-ubiquinone oxidoreductase B15 subunit;Complex I-B15 NDUFB4 O95168 ENST00000184266;ENST00000400812 K03960 1 0.80308 1.5903 0.80625 1.0151 1.0434 1.0041 Ndufs5 cytoplasmic part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;mitochondrial membrane part;mitochondrial part;mitochondrial respiratory chain complex I;NADH dehydrogenase complex;organelle part;protein complex catalytic activity;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor anatomical structure formation;cellular process;generation of precursor metabolites and energy;metabolic process;mitochondrial electron transport, NADH to ubiquinone;NADH dehydrogenase complex assembly;protein complex assembly;transport Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 4 4 4 36.8 36.8 36.8 12.517 5.1147E-12 53815000 29038000 24777000 3536 IPI:IPI00220063.5 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5;NADH-ubiquinone oxidoreductase 15 kDa subunit;Complex I-15 kDa NDUFS5 O43920 ENST00000372967;ENST00000372969 K03938 1 1.4421 2.8177 NaN 1.799 2.0177 NaN DnaJ;UIM binding;heat shock protein binding;protein binding;unfolded protein binding cellular biopolymer metabolic process;cellular process;metabolic process;protein folding;protein metabolic process;response to biotic stimulus;response to chemical stimulus;response to organic substance;response to stress;response to unfolded protein 2 2 2 5.9 5.9 5.9 35.58 0.00049604 13325000 7194000 6131400 3538 IPI:IPI00220102.1;IPI:IPI00874105.1 DnaJ homolog subfamily B member 2;Heat shock 40 kDa protein 3;DnaJ protein homolog 1;HSJ-1 DNAJB2;HSJ1;HSPF3 P25686-3;P25686;P25686-2 ENST00000336576;ENST00000392087 K09508 2 NaN 1.3569 0.52395 NaN 0.67211 0.81717 Helicase_C;SNF2_N cell part;chromatin;chromosomal part;heterochromatin;intracellular organelle part;intracellular part;nuclear chromatin;nuclear chromosome part;nuclear heterochromatin;nuclear part;organelle part ATP binding;binding;catalytic activity;DNA binding;DNA helicase activity;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity;zinc ion binding DNA alkylation;DNA metabolic process;DNA methylation;DNA modification;DNA recombination;DNA repair;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;one-carbon metabolic process;regulation of transcription, DNA-dependent 2 2 2 1 1 1 282.52 0.0059388 6062600 5562700 499920 3539 IPI:IPI00297633.6;IPI:IPI00845355.1;IPI:IPI00220109.6;IPI:IPI00938010.1;IPI:IPI00883721.2;IPI:IPI00940810.1 Transcriptional regulator ATRX;ATP-dependent helicase ATRX;X-linked helicase II;X-linked nuclear protein;Znf-HX ATRX;RAD54L;XH2 P46100-1;P46100;P46100-4;P46100-5;P46100-3;P46100-2;P46100-6 ENST00000343347;ENST00000373342;ENST00000373344;ENST00000395603;ENST00000395605;ENST00000400870;ENST00000400871 K10779 6 0.25999 NaN NaN 0.32745 NaN NaN Oxysterol_BP;PH cell part;cytoplasmic part;cytosol;intracellular part binding;lipid binding;oxysterol binding;protein binding;steroid binding;sterol binding alcohol metabolic process;biosynthetic process;cholesterol metabolic process;Golgi to plasma membrane transport;lipid metabolic process;lipid transport;metabolic process;post-Golgi vesicle-mediated transport;steroid metabolic process;transport 3 1 1 3.5 1.3 1.3 98.615 0.00065377 730150 417460 312690 3540 IPI:IPI00220116.7 Oxysterol-binding protein-related protein 5;Oxysterol-binding protein homolog 1; OSBPL5;KIAA1534;OBPH1;ORP5 Q9H0X9 ENST00000263650 1 0.55479 1.2146 1.1343 0.75061 0.79884 1.5165 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding cell cycle;DNA metabolic process;DNA repair;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of cyclin-dependent protein kinase activity;response to DNA damage stimulus;response to stress 8 1 1 32.9 3.1 3.1 36.214 1.5703E-304 35119000 17802000 17316000 3541 IPI:IPI00220152.2 BRCA2 and CDKN1A-interacting protein;Protein TOK-1;P21- and CDK-associated protein 1 BCCIP;TOK1 Q9P287-2;Q9P287 ENST00000278100;ENST00000368759;ENST00000392718 1 0.81381 1.5153 0.71934 1.0099 0.97055 0.96051 Sugar_tr cell fraction;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;insoluble fraction;integral to membrane;intracellular organelle;intrinsic to membrane;melanosome;membrane fraction;membrane-bounded organelle;membrane-bounded vesicle;organelle;vesicle cation transmembrane transporter activity;cation:sugar symporter activity;glucose transmembrane transporter activity;ion transmembrane transporter activity;sugar:hydrogen symporter activity;transporter activity carbohydrate transport;cellular process;establishment of localization;glucose transport;hexose transport;monosaccharide transport;transmembrane transport;transport Adipocytokine signaling pathway;Pathways in cancer;Renal cell carcinoma 6 6 5 8.9 8.9 7.7 54.083 2.0735E-70 144050000 78190000 65857000 3542 IPI:IPI00220194.6 Solute carrier family 2, facilitated glucose transporter member 1;Glucose transporter type 1, erythrocyte/brain;HepG2 glucose transporter SLC2A1;GLUT1 P11166 ENST00000372501;ENST00000397019 K07299 1 0.71277 1.3923 0.73305 0.94943 0.92682 0.93687 Coatomer_WDAD;WD40 cell part;COPI vesicle coat;cytoplasmic part;cytoplasmic vesicle part;cytosol;Golgi apparatus part;intracellular organelle part;intracellular part;macromolecular complex;membrane coat;membrane part;organelle part;protein complex;vesicle coat binding;protein binding;structural molecule activity cellular component organization;cellular process;intracellular protein transport;intra-Golgi vesicle-mediated transport;organelle organization;protein transport;retrograde vesicle-mediated transport, Golgi to ER;transport;vesicle coating 32 32 32 40.2 40.2 40.2 102.49 0 1983400000 1063400000 919920000 3543 IPI:IPI00220219.6 Coatomer subunit beta';Beta'-coat protein;p102 COPB2 P35606 ENST00000333188 1 0.16881 NaN NaN 0.23736 NaN NaN Pkinase;RGS cell part;membrane ATP binding;binding;catalytic activity;G-protein coupled receptor kinase activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;signal transducer activity cell communication;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;regulation of G-protein coupled receptor protein signaling pathway;signal transduction Chemokine signaling pathway 3 3 3 7.1 7.1 7.1 67.257 3.3245E-07 8192400 5708700 2483800 3544 IPI:IPI00220242.6;IPI:IPI00017330.2 G protein-coupled receptor kinase 6;G protein-coupled receptor kinase GRK6 GRK6;GPRK6 P43250-2;P43250;P43250-1 ENST00000355472;ENST00000393576 K08291 2 1.0299 2.1082 NaN 1.3647 1.3646 NaN Lyase_1 cell part;cytoplasm;intracellular part amidine-lyase activity;argininosuccinate lyase activity;carbon-nitrogen lyase activity;catalytic activity;lyase activity arginine biosynthetic process;arginine catabolic process;arginine metabolic process;cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;organic acid metabolic process;ornithine metabolic process;urea cycle Alanine and aspartate metabolism;Arginine and proline metabolism 2 2 2 6.5 6.5 6.5 51.657 2.1399E-10 661440 388480 272960 3545 IPI:IPI00220267.7 Argininosuccinate lyase;Arginosuccinase ASL P04424 ENST00000304874;ENST00000362000;ENST00000395332 K01755 1 0.74488 1.3927 0.78886 0.97959 0.95722 0.99144 Aldo_ket_red alcohol dehydrogenase (NADP+) activity;aldehyde reductase activity;aldo-keto reductase activity;binding;catalytic activity;electron carrier activity;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;protein binding alcohol metabolic process;carbohydrate metabolic process;glucose metabolic process;hexose metabolic process;metabolic process;monosaccharide metabolic process;oxidation reduction;primary metabolic process Caprolactam degradation;Glycerolipid metabolism;Glycolysis / Gluconeogenesis 15 15 15 68 68 68 36.573 0 853290000 456080000 397210000 3546 IPI:IPI00220271.3 Alcohol dehydrogenase [NADP+];Aldehyde reductase;Aldo-keto reductase family 1 member A1 AKR1A1;ALDR1;ALR P14550 ENST00000351829;ENST00000372070 K00002 1 NaN 0.78643 NaN NaN 0.49331 NaN BRK;Chromo;Helicase_C;SNF2_N cell part;chromatin;chromosomal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;nucleus;organelle;organelle part ATP binding;ATP-dependent helicase activity;binding;catalytic activity;chromatin binding;DNA binding;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity chromatin assembly or disassembly;chromatin organization;chromatin remodeling;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 4 1 1 1.6 0.4 0.4 305.41 1.7246E-20 314390 198810 115580 3547 IPI:IPI00220289.7 Chromodomain-helicase-DNA-binding protein 6;ATP-dependent helicase CHD6;Radiation-induced gene B protein CHD6;CHD5;KIAA1335;RIGB Q8TD26-1;Q8TD26 ENST00000309279;ENST00000373222;ENST00000373233 1 0.64793 1.3367 0.65068 0.80876 0.93917 0.80364 MoCF_biosynth;PAPS_reduct cell part;cytoplasmic part;cytosol;intracellular part ATP binding;binding;catalytic activity;FMN adenylyltransferase activity;nucleoside binding;nucleotide binding;nucleotidyltransferase activity;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups cellular aromatic compound metabolic process;coenzyme metabolic process;FAD biosynthetic process;FADH2 metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;oxidoreduction coenzyme metabolic process Riboflavin metabolism 7 7 7 16.7 16.7 16.7 65.265 1.0965E-44 3655400 1890700 1764600 3548 IPI:IPI00220299.1;IPI:IPI00642864.2;IPI:IPI00398214.2;IPI:IPI00855871.1;IPI:IPI00387088.1 FAD synthetase;FMN adenylyltransferase;FAD pyrophosphorylase;Flavin adenine dinucleotide synthetase;Molybdenum cofactor biosynthesis protein-like region;FAD synthetase region FLAD1;PP591 Q8NFF5-1;Q8NFF5;Q8NFF5-2;Q8NFF5-3 ENST00000292180;ENST00000315144;ENST00000405236 K00953 5 0.74208 1.7026 0.84326 0.9616 1.1658 1.0481 WRW intracellular part;macromolecular complex;mitochondrial proton-transporting ATP synthase complex;organelle part;protein complex;proton-transporting two-sector ATPase complex;proton-transporting two-sector ATPase complex, proton-transporting domain cation transmembrane transporter activity;hydrogen ion transmembrane transporter activity;ion transmembrane transporter activity;monovalent inorganic cation transmembrane transporter activity;transmembrane transporter activity;transporter activity ATP biosynthetic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;transport Oxidative phosphorylation 5 5 5 52.1 52.1 52.1 10.918 7.6275E-71 180980000 97519000 83459000 3549 IPI:IPI00220300.5;IPI:IPI00219291.5 ATP synthase subunit f, mitochondrial ATP5J2;ATP5JL P56134-1;P56134;P56134-2 ENST00000292475;ENST00000394186 K02130 2 0.81895 1.6646 0.80126 1.0796 1.0803 1.0802 1-cysPrx_C;AhpC-TSA cell part;cytoplasmic part;cytoplasmic vesicle;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;lysosome;lytic vacuole;membrane-bounded organelle;nucleus;organelle;vacuole;vesicle antioxidant activity;carboxylesterase activity;catalytic activity;hydrolase activity;lipase activity;oxidoreductase activity;oxidoreductase activity, acting on peroxide as acceptor;peroxidase activity;phospholipase A2 activity;phospholipase activity catabolic process;cellular process;lipid catabolic process;lipid metabolic process;metabolic process;organophosphate metabolic process;phospholipid catabolic process;phospholipid metabolic process;response to oxidative stress;response to stress 2,4-Dichlorobenzoate degradation;Alkaloid biosynthesis II;Methane metabolism;Phenylalanine metabolism;Phenylpropanoid biosynthesis 15 15 15 64.7 64.7 64.7 25.035 0 2510200000 1321900000 1188300000 3550 IPI:IPI00220301.5 Peroxiredoxin-6;Antioxidant protein 2;1-Cys peroxiredoxin;Acidic calcium-independent phospholipase A2;Non-selenium glutathione peroxidase;24 kDa protein;Liver 2D page spot 40;Red blood cells page spot 12 PRDX6;AOP2;KIAA0106 P30041 ENST00000340385 K00430;K01066;K11188 1 0.69475 1.531 0.79205 0.88189 0.96627 1.1327 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane;non-membrane-bounded organelle;nuclear membrane;nuclear part;nucleolus;organelle;organelle membrane;organelle part cell cycle;cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 8 8 8 28 28 28 44.243 2.2846E-148 48392000 25617000 22776000 3551 IPI:IPI00220302.1;IPI:IPI00014150.1 Pre-mRNA-splicing regulator WTAP;Wilms tumor 1-associating protein;WT1-associated protein;Female-lethal(2)D homolog WTAP;KIAA0105 Q15007-1;Q15007 ENST00000337387;ENST00000358372;ENST00000401980 2 1.0871 1.9756 NaN 1.513 1.3095 NaN ERM;FERM_C;FERM_M;FERM_N cell projection membrane;cytoskeleton;early endosome;endosome;extrinsic to membrane;filopodium membrane;intracellular organelle;leading edge membrane;membrane-bounded organelle;non-membrane-bounded organelle;nucleolus;organelle;ruffle membrane binding;cytoskeletal protein binding;protein binding negative regulation of cell-matrix adhesion;negative regulation of protein amino acid phosphorylation;organelle organization;regulation of cell-matrix adhesion;regulation of DNA replication;regulation of protein amino acid phosphorylation;system process 5 5 5 8.1 8.1 8.1 72.513 1.6946E-15 13180000 6273400 6906700 3552 IPI:IPI00220308.1;IPI:IPI00414431.2;IPI:IPI00304755.2;IPI:IPI00220314.1;IPI:IPI00220311.1;IPI:IPI00220312.1;IPI:IPI00220310.1;IPI:IPI00414202.2;IPI:IPI00216128.1 Merlin;Moesin-ezrin-radixin-like protein;Neurofibromin-2;Schwannomin;Schwannomerlin NF2;SCH P35240-2;P35240;P35240-1;P35240-3;P35240-8;P35240-5;P35240-6;P35240-4 ENST00000334961;ENST00000338641;ENST00000347330;ENST00000353887;ENST00000361166;ENST00000361452;ENST00000361676;ENST00000397789;ENST00000397822 9 0.40514 0.86684 0.42792 0.54267 0.5594 0.5514 DNA_pol_B;DNA_pol_B_exo;zf-DNA_Pol alpha DNA polymerase:primase complex;cytoplasm;envelope;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nuclear envelope;nuclear matrix;nucleolus;nucleoplasm;organelle;organelle envelope binding;catalytic activity;chromatin binding;DNA binding;DNA-directed DNA polymerase activity;nucleic acid binding;nucleoside binding;nucleotide binding;transferase activity;transferase activity, transferring phosphorus-containing groups;zinc ion binding DNA metabolic process;DNA replication;DNA replication initiation;DNA synthesis during DNA repair;non-recombinational repair;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;S phase of mitotic cell cycle DNA replication 7 7 7 4.4 4.4 4.4 165.91 5.9549E-16 18768000 9884700 8883100 3553 IPI:IPI00220317.3 DNA polymerase alpha catalytic subunit POLA1;POLA P09884 ENST00000379059;ENST00000379068 K02320 1 0.028908 25.054 0.047243 0.039647 15.19 0.066516 Filament cell part;membrane;plasma membrane binding;carbohydrate binding;molecular transducer activity;protein binding;receptor activity;signal transducer activity;structural constituent of cytoskeleton;structural molecule activity;sugar binding activation of immune response;activation of plasma proteins involved in acute inflammatory response;complement activation, lectin pathway;immune effector process;immune system process;regulation of immune system process + 62 62 46 71.9 71.9 62.1 66.038 0 31339000000 30081000000 1258400000 3554 IPI:IPI00220327.4;IPI:CON_00220327.3;IPI:CON_IPI00748057.2 Keratin, type II cytoskeletal 1;Cytokeratin-1;Keratin-1;67 kDa cytokeratin;Hair alpha protein KRT1;KRTA P04264 ENST00000252244 K07605 3 0.43773 NaN NaN 0.57242 NaN NaN LSM cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;small nuclear ribonucleoprotein complex;spliceosomal complex binding;identical protein binding;nucleic acid binding;protein binding;RNA binding cellular biopolymer metabolic process;cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 10 1 1 40.8 5.8 5.8 24.614 9.56E-184 1425500 1004600 420990 3555 IPI:IPI00220360.2 Small nuclear ribonucleoprotein-associated protein N;Tissue-specific-splicing protein SNRPN;HCERN3;SMN P63162 ENST00000338094;ENST00000390687;ENST00000400097;ENST00000400098;ENST00000400100 K11100 1 1.4895 2.7402 1.5166 1.9103 1.8958 1.9696 Cpn10 cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding activation of caspase activity;cellular process;metabolic process;positive regulation of peptidase activity;protein folding;regulation of cell death;response to biotic stimulus;response to organic substance;response to stress;response to unfolded protein 15 15 15 93.1 93.1 93.1 10.932 1.273E-169 15910000000 7306500000 8603800000 3556 IPI:IPI00220362.5 10 kDa heat shock protein, mitochondrial;10 kDa chaperonin;CPN10;Early-pregnancy factor HSPE1 P61604 ENST00000233893 K04078 1 0.65601 1.3258 0.65513 0.89395 0.91436 0.87391 Peptidase_M16;Peptidase_M16_C cell fraction;cell part;cytoplasmic part;extracellular region part;extracellular space;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;microbody;organelle;peroxisome;soluble fraction binding;catalytic activity;cation binding;endopeptidase activity;hydrolase activity;ion binding;metal ion binding;metalloendopeptidase activity;metallopeptidase activity;peptidase activity;signal transducer activity;zinc ion binding catabolic process;cell communication;cellular process;macromolecule catabolic process;metabolic process;protein metabolic process;proteolysis;reproductive developmental process;reproductive process;sex differentiation;signal transduction Alzheimer's disease 22 22 22 23.6 23.6 23.6 117.97 1.8261E-147 433120000 239240000 193880000 3557 IPI:IPI00220373.5 Insulin-degrading enzyme;Insulin protease;Insulysin IDE P14735 ENST00000265986 K01408 1 0.83651 1.5392 0.84024 1.1443 0.99187 1.1412 IPP-2 binding;enzyme inhibitor activity;phosphatase inhibitor activity;phosphatase regulator activity;phosphoprotein phosphatase inhibitor activity;protein binding;protein phosphatase regulator activity;protein serine/threonine phosphatase inhibitor activity carbohydrate metabolic process;cellular glucan metabolic process;energy reserve metabolic process;generation of precursor metabolites and energy;glycogen metabolic process;metabolic process;polysaccharide metabolic process 3 3 3 17.1 17.1 17.1 23.015 6.9949E-61 105410000 56424000 48988000 3558 IPI:IPI00220402.3;IPI:IPI00410126.3 Protein phosphatase inhibitor 2;Putative protein phosphatase inhibitor 2-like protein 3;Protein phosphatase 1, regulatory subunit 2 pseudogene 3 PPP1R2;IPP2;PPP1R2P3 P41236;Q6NXS1 ENST00000328432 2 NaN 1.4818 0.72962 NaN 1.0279 0.89501 AMPKBI cell part;cytoplasm;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;nuclear part;nucleoplasm;nucleus;organelle;organelle part binding;protein binding biosynthetic process;cell communication;cellular process;fatty acid biosynthetic process;fatty acid metabolic process;lipid biosynthetic process;lipid metabolic process;metabolic process;organic acid metabolic process;signal transduction Adipocytokine signaling pathway;Insulin signaling pathway 2 2 2 7.8 7.8 7.8 30.382 1.9161E-06 31182000 16277000 14905000 3559 IPI:IPI00220409.3;IPI:IPI00013905.1 5'-AMP-activated protein kinase subunit beta-1;5'-AMP-activated protein kinase subunit beta-2 PRKAB1;AMPK;PRKAB2 Q9Y478;O43741 ENST00000229328;ENST00000254101 K07199 2 0.7658 1.375 0.69477 0.96648 0.90642 0.91308 UCR_14kD cell part;cytoplasmic part;intracellular organelle part;intracellular part;membrane part;mitochondrial membrane part;mitochondrial part;mitochondrial respiratory chain;organelle part;respiratory chain catalytic activity;cation transmembrane transporter activity;ion transmembrane transporter activity;monovalent inorganic cation transmembrane transporter activity;transporter activity;ubiquinol-cytochrome-c reductase activity aerobic respiration;cellular process;electron transport chain;energy derivation by oxidation of organic compounds;generation of precursor metabolites and energy;metabolic process;mitochondrial electron transport, ubiquinol to cytochrome c;transport Alzheimer's disease;Cardiac muscle contraction;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 6 6 6 45.9 45.9 45.9 13.53 1.8817E-20 191100000 93034000 98064000 3560 IPI:IPI00220416.3 Cytochrome b-c1 complex subunit 7;Ubiquinol-cytochrome c reductase complex 14 kDa protein;Complex III subunit 7;Complex III subunit VII;QP-C UQCRB;UQBP P14927 ENST00000287022 K00417 1 0.56845 1.0318 NaN 0.76408 0.67767 NaN SAP;zf-MIZ cell part;intracellular organelle part;intracellular part;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part binding;catalytic activity;DNA binding;nucleic acid binding;protein binding;receptor binding;transcription coactivator activity;transcription cofactor activity;transcription corepressor activity;transcription factor binding;zinc ion binding cell communication;intracellular signaling cascade;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;proteolysis;regulation of transcription, DNA-dependent;signal transduction;transcription Jak-STAT signaling pathway;Pathways in cancer;Small cell lung cancer;Ubiquitin mediated proteolysis 2 2 1 3.7 3.7 1.4 72.203 2.1804E-10 17373000 10253000 7120700 3561 IPI:IPI00220424.7 E3 SUMO-protein ligase PIAS1;Protein inhibitor of activated STAT protein 1;Gu-binding protein;RNA helicase II-binding protein;DEAD/H box-binding protein 1 PIAS1;DDXBP1 O75925 ENST00000249636 K04706 1 NaN 1.8072 NaN NaN 1.249 NaN FHA cell part;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;nucleoplasm;organelle;organelle part binding;protein binding biopolymer metabolic process;biopolymer modification;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;protein metabolic process;protein modification process 2 2 2 6.5 6.5 6.5 53 2.2154E-05 10066000 5620700 4445800 3563 IPI:IPI00220477.3;IPI:IPI00479000.1;IPI:IPI00655820.1 Microspherule protein 1;58 kDa microspherule protein;Cell cycle-regulated factor p78;MCRS2;INO80 complex subunit J MCRS1;INO80Q;MSP58 Q96EZ8-2;Q96EZ8;Q96EZ8-1;Q96EZ8-3 ENST00000343810;ENST00000357123;ENST00000403052 K11674 3 0.74078 1.6734 0.74249 0.94416 1.1211 0.95769 Mt_ATP-synt_D intracellular part;macromolecular complex;membrane part;mitochondrial proton-transporting ATP synthase complex, coupling factor F(o);organelle part;protein complex;proton-transporting two-sector ATPase complex, proton-transporting domain cation transmembrane transporter activity;hydrogen ion transmembrane transporter activity;ion transmembrane transporter activity;monovalent inorganic cation transmembrane transporter activity;transmembrane transporter activity;transporter activity ATP biosynthetic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;transport Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 11 11 11 75.8 75.8 75.8 18.491 7.888E-90 1001400000 541380000 460040000 3565 IPI:IPI00220487.4;IPI:IPI00456049.3 ATP synthase subunit d, mitochondrial ATP5H;My032 O75947-1;O75947;O75947-2 ENST00000301587;ENST00000344546 K02138 2 NaN NaN 0.38817 NaN NaN 0.53342 LSM cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;ribonucleoprotein complex binding;nucleic acid binding;protein binding;RNA binding cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 2 2 2 50.5 50.5 50.5 9.9374 9.1656E-36 23808000 14204000 9604100 3566 IPI:IPI00220493.5 U6 snRNA-associated Sm-like protein LSm5 LSM5 Q9Y4Y9 ENST00000223084 1 0.82366 1.6364 0.87546 1.0321 1.1185 1.1032 Dynamitin centrosome;dynactin complex;dynein complex;intracellular organelle;kinetochore;macromolecular complex;membrane;microtubule;microtubule associated complex;microtubule organizing center;non-membrane-bounded organelle;organelle binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;motor activity;protein binding;pyrophosphatase activity cell cycle phase;cell cycle process;cell proliferation;cellular component organization;cellular process;microtubule-based process;mitosis;nuclear division;organelle fission;organelle organization Huntington's disease 16 16 16 45.1 45.1 45.1 44.819 0 822640000 430050000 392590000 3567 IPI:IPI00220503.9 Dynactin subunit 2;Dynactin complex 50 kDa subunit;50 kDa dynein-associated polypeptide;p50 dynamitin DCTN2;DCTN50 Q13561 ENST00000354743 K10424 1 0.78742 1.6329 0.812 0.97716 1.0456 1.0865 KA1;Pkinase;UBA ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cellular biopolymer metabolic process;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process 11 11 7 18.1 18.1 12.5 84.488 2.0133E-47 38007000 19756000 18251000 3568 IPI:IPI00220508.2;IPI:IPI00220507.2;IPI:IPI00220506.2;IPI:IPI00220509.2;IPI:IPI00183118.5;IPI:IPI00220510.2;IPI:IPI00220505.2;IPI:IPI00185037.9;IPI:IPI00555711.2;IPI:IPI00292809.6;IPI:IPI00064797.1;IPI:IPI00297959.1 MAP/microtubule affinity-regulating kinase 3;Cdc25C-associated protein kinase 1;C-TAK1;Serine/threonine-protein kinase p78;Ser/Thr protein kinase PAR-1;Protein kinase STK10 MARK3;CTAK1 P27448-5;P27448;P27448-4;P27448-3;P27448-6;P27448-1;P27448-7;P27448-2 ENST00000216288;ENST00000303622;ENST00000335102 K08798 12 0.9013 1.7317 0.95961 1.2078 1.1627 1.2938 PX;Sorting_nexin;Vps5 cytoplasmic part;endosomal part;endosome membrane;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;organelle;organelle membrane;organelle part binding;lipid binding;phosphoinositide binding;phospholipid binding;protein binding;protein transporter activity;substrate-specific transporter activity;transporter activity cell communication;cellular component organization;cellular process;endocytosis;establishment of protein localization;intracellular protein transport;membrane invagination;membrane organization;protein transport;transport;vesicle-mediated transport 17 15 1 42.7 38.1 3.1 51.812 1.0198E-204 875140000 436610000 438540000 3569 IPI:IPI00220527.5 Sorting nexin-1 SNX1 Q13596-2;Q13596 ENST00000261889;ENST00000380285 1 0.88308 1.4015 0.77837 1.0575 0.9847 1.0171 LSM cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;ribonucleoprotein complex;small nuclear ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;protein binding;RNA binding cellular component biogenesis;cellular process;ribonucleoprotein complex biogenesis;spliceosomal snRNP biogenesis 4 4 4 33.7 33.7 33.7 9.7251 4.0519E-44 1608000000 808360000 799690000 3570 IPI:IPI00220528.6 Small nuclear ribonucleoprotein F SNRPF;PBSCF P62306 ENST00000266735 K11098 1 0.86653 1.5604 NaN 1.0812 1.0401 NaN 5-FTHF_cyc-lig cell part;cytoplasmic part;cytosol;intracellular part amino acid binding;ATP binding;binding;catalytic activity;cyclo-ligase activity;folic acid binding;ligase activity;ligase activity, forming carbon-nitrogen bonds;magnesium ion binding;nucleoside binding;nucleotide binding;purine nucleoside binding biosynthetic process;cellular aromatic compound metabolic process;coenzyme metabolic process;folic acid and derivative metabolic process;group transfer coenzyme metabolic process;metabolic process;organic acid metabolic process One carbon pool by folate 3 3 3 17.2 17.2 17.2 23.255 3.1306E-13 38476000 21941000 16536000 3571 IPI:IPI00220567.5 5-formyltetrahydrofolate cyclo-ligase;5,10-methenyl-tetrahydrofolate synthetase MTHFS P49914 ENST00000258874 K01934 1 0.90259 1.7124 0.94273 1.1432 1.0031 1.2124 G-alpha binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;pyrophosphatase activity;signal transducer activity cell communication;cell surface receptor linked signal transduction;G-protein coupled receptor protein signaling pathway;negative regulation of adenylate cyclase activity;regulation of nucleotide metabolic process;signal transduction;transport Axon guidance;Chemokine signaling pathway;Gap junction;Leukocyte transendothelial migration;Long-term depression;Melanogenesis;Progesterone-mediated oocyte maturation;Tight junction 13 7 7 40.4 21.2 21.2 40.532 1.7942E-227 206320000 100180000 106130000 3572 IPI:IPI00220578.3 Guanine nucleotide-binding protein G(k) subunit alpha;G(i) alpha-3 GNAI3 P08754 ENST00000369851 K04630 1 0.86529 1.738 0.81389 1.1572 1.1064 1.1048 BAR;SH3_1 actin cytoskeleton;cytoplasm;cytoskeleton;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle binding;protein binding cell cycle;cell differentiation;cell proliferation;cellular component organization;cellular process;endocytosis;membrane invagination;membrane organization;multicellular organismal development;regulation of endocytosis;transport;vesicle-mediated transport 4 4 4 10.2 10.2 10.2 56.498 8.3649E-40 79841000 42831000 37010000 3573 IPI:IPI00220996.1;IPI:IPI00220587.1;IPI:IPI00220998.1;IPI:IPI00329733.2;IPI:IPI00221000.1;IPI:IPI00220999.3;IPI:IPI00220586.1;IPI:IPI00221001.1;IPI:IPI00186966.3;IPI:IPI00395680.2;IPI:IPI00220997.1 Myc box-dependent-interacting protein 1;Bridging integrator 1;Amphiphysin-like protein;Box-dependent myc-interacting protein 1 BIN1;AMPHL O00499-2;O00499;O00499-11;O00499-6;O00499-4;O00499-8;O00499-7;O00499-10;O00499-9;O00499-1;O00499-5;O00499-3 ENST00000259238;ENST00000316724;ENST00000346226;ENST00000348750;ENST00000351659;ENST00000352848;ENST00000357970;ENST00000376113 11 0.88735 1.7358 0.91809 1.2071 1.1301 1.1627 Seryl_tRNA_N;tRNA-synt_2b cell part;cytoplasm;intracellular part aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;ligase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;RNA binding;serine-tRNA ligase activity nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;RNA processing;seryl-tRNA aminoacylation;tRNA aminoacylation for protein translation;tRNA metabolic process Aminoacyl-tRNA biosynthesis;Glycine, serine and threonine metabolism 25 25 25 52.7 52.7 52.7 58.777 2.1491E-215 1427300000 739450000 687850000 3574 IPI:IPI00220637.5 Seryl-tRNA synthetase, cytoplasmic;Seryl-tRNA(Ser/Sec) synthetase;Serine--tRNA ligase SARS;SERS P49591 ENST00000234677;ENST00000369923 K01875 1 0.93075 1.7432 0.9507 1.2461 1.1286 1.1993 14-3-3 cell part;cytoplasm;intracellular part binding;enzyme inhibitor activity;insulin-like growth factor receptor binding;kinase regulator activity;protein binding;protein kinase C binding;protein kinase C inhibitor activity;protein kinase inhibitor activity;receptor binding negative regulation of protein kinase activity;regulation of cell communication;regulation of cellular metabolic process;regulation of metabolic process;regulation of phosphate metabolic process;regulation of signal transduction Cell cycle 15 11 11 66 55.5 55.5 28.302 0 2546800000 1276200000 1270600000 3575 IPI:IPI00220642.7 14-3-3 protein gamma;Protein kinase C inhibitor protein 1;14-3-3 protein gamma, N-terminally processed YWHAG P61981 ENST00000307630 K06630 1 0.76575 1.6181 0.67019 0.92272 1.1024 0.93622 PK;PK_C cell part;cytoplasmic part;cytosol;intracellular part ATP binding;binding;catalytic activity;kinase activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyruvate kinase activity;transferase activity alcohol metabolic process;carbohydrate metabolic process;catabolic process;cellular process;generation of precursor metabolites and energy;glucose catabolic process;glucose metabolic process;glycolysis;metabolic process;monosaccharide metabolic process Carbon fixation in photosynthetic organisms;Glycolysis / Gluconeogenesis;Purine metabolism;Pyruvate metabolism;Type II diabetes mellitus 44 3 3 68.7 4.1 4.1 58.061 0 168780000 91496000 77288000 3576 IPI:IPI00220644.8 Pyruvate kinase isozymes M1/M2;Pyruvate kinase muscle isozyme;Pyruvate kinase 2/3;Cytosolic thyroid hormone-binding protein;THBP1;p58;M2-PK;Tumor M2-PK PKM2;PK2;PK3;PKM P14618-2;P14618 ENST00000319622;ENST00000335181;ENST00000389093 K00873 1 0.78597 1.5207 0.88968 1.0144 1.055 1.1424 P-mevalo_kinase cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;microbody;organelle;peroxisome ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;phosphomevalonate kinase activity;protein binding;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups alcohol metabolic process;cholesterol biosynthetic process;lipid metabolic process;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;steroid biosynthetic process Biosynthesis of steroids 13 13 13 60.9 60.9 60.9 21.995 2.2265E-147 655620000 318600000 337020000 3577 IPI:IPI00220648.5 Phosphomevalonate kinase PMVK;PMKI Q15126 ENST00000368467 K00938 1 NaN NaN 0.5149 NaN NaN 0.71826 Cpn60_TCP1 cell part;cytoplasm;intracellular part adenyl nucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;protein binding;protein transporter activity;purine nucleoside binding;purine nucleotide binding;substrate-specific transporter activity;transporter activity anatomical structure formation;cellular component assembly;cellular component organization;cellular process;gamete generation;metabolic process;protein complex assembly;protein folding;protein metabolic process;reproductive process;spermatogenesis 7 3 3 14.2 7 7 57.765 7.1333E-42 16347000 7938900 8408200 3578 IPI:IPI00220656.4 T-complex protein 1 subunit zeta-2;CCT-zeta-2;TCP-1-zeta-like;CCT-zeta-like;Testis-specific Tcp20;Testis-specific protein TSA303 CCT6B Q92526 ENST00000314144 K09498 1 0.75255 1.4648 0.75489 0.96757 0.98746 0.97712 Cyt-b5 cell fraction;cell surface;endoplasmic reticulum membrane;insoluble fraction;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane;membrane fraction;microsome;nucleolus;organelle membrane binding;cation binding;heme binding;ion binding;iron ion binding;lipid binding;metal ion binding;molecular transducer activity;protein binding;receptor activity;signal transducer activity;steroid binding;tetrapyrrole binding;transition metal ion binding 5 5 4 24.1 24.1 19.5 21.671 5.7147E-72 571300000 303540000 267750000 3579 IPI:IPI00220739.3 Membrane-associated progesterone receptor component 1 PGRMC1;HPR6.6;PGRMC O00264 ENST00000217971 1 0.65166 1.3754 0.67695 0.90084 0.86737 0.90084 Nucleoplasmin centrosome;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;microtubule organizing center;non-membrane-bounded organelle;nucleolus;nucleoplasm;organelle;ribonucleoprotein complex;spindle pole centrosome binding;histone binding;nucleic acid binding;protein binding;RNA binding;Tat protein binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding;transcription regulator activity anti-apoptosis;cell communication;centrosome cycle;chromatin organization;intracellular protein transport;nucleocytoplasmic transport;nucleosome assembly;organelle organization;protein complex assembly;response to stress;signal transduction;transport 15 15 15 46.3 46.3 46.3 32.575 0 14777000000 7915800000 6861600000 3580 IPI:IPI00549248.4;IPI:IPI00220740.1 Nucleophosmin;Nucleolar phosphoprotein B23;Numatrin;Nucleolar protein NO38 NPM1;NPM P06748-1;P06748;P06748-2 ENST00000296930;ENST00000351986 2 0.80337 1.4674 0.81246 1.0176 0.97963 1.0555 Glyoxalase cell part;cytoplasm;intracellular part binding;carbon-sulfur lyase activity;catalytic activity;cation binding;ion binding;lactoylglutathione lyase activity;lyase activity;metal ion binding;transition metal ion binding;zinc ion binding anti-apoptosis;carbohydrate metabolic process;metabolic process;negative regulation of apoptosis;negative regulation of programmed cell death;primary metabolic process;regulation of apoptosis;regulation of cell death;regulation of programmed cell death MAPK signaling pathway - yeast;Pyruvate metabolism 10 10 10 54.9 54.9 54.9 20.777 4.2993E-207 2179200000 1159300000 1019900000 3581 IPI:IPI00220766.5 Lactoylglutathione lyase;Methylglyoxalase;Aldoketomutase;Glyoxalase I;Ketone-aldehyde mutase;S-D-lactoylglutathione methylglyoxal lyase GLO1 Q04760 ENST00000373365 K01759 1 0.7194 1.3534 0.75509 0.9902 0.84414 1.1039 Endosulfine cell part;cytoplasm;intracellular part auxiliary transport protein activity;binding;channel inhibitor activity;channel regulator activity;ion channel inhibitor activity;protein binding;receptor binding establishment of localization;response to chemical stimulus;response to external stimulus;response to extracellular stimulus;response to nutrient;response to nutrient levels;response to stimulus;transport 6 6 6 57.1 57.1 57.1 15.533 7.5776E-138 252780000 129250000 123530000 3583 IPI:IPI00929648.1;IPI:IPI00644717.1;IPI:IPI00383552.4;IPI:IPI00220797.1;IPI:IPI00410179.1;IPI:IPI00410180.1;IPI:IPI00410181.1;IPI:IPI00410387.1;IPI:IPI00328526.6;IPI:IPI00745466.1 Alpha-endosulfine;ARPP-19e ENSA O43768-4;O43768;O43768-3;O43768-1;O43768-2;O43768-7;O43768-5;O43768-6;O43768-8 ENST00000271690;ENST00000369014;ENST00000369016 10 0.65 1.9345 0.79577 0.92987 1.0751 1.1067 Thymosin cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle actin binding;binding;cytoskeletal protein binding;protein binding cellular process;cytoskeleton organization;negative regulation of macromolecule metabolic process;negative regulation of metabolic process;organelle organization;regulation of actin polymerization or depolymerization 3 3 3 63.6 63.6 63.6 5.0256 2.8269E-39 1419900000 742210000 677740000 3584 IPI:IPI00220827.5;IPI:CON_00695841.2 Thymosin beta-10 TMSB10;PTMB10;THYB10 P63313 ENST00000233143 2 0.65432 1.2855 0.63243 0.87075 0.85084 0.85255 Ku;Ku_C;Ku_N;Ku_PK_bind cell part;chromosomal part;intracellular organelle part;intracellular part;macromolecular complex;nuclear chromosome part;nuclear part;nuclear telomere cap complex;nucleoplasm;organelle part;protein-DNA complex;telomere cap complex ATP binding;ATP-dependent DNA helicase activity;binding;catalytic activity;DNA binding;DNA helicase activity;double-stranded DNA binding;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding DNA metabolic process;DNA recombination;DNA repair;double-strand break repair;double-strand break repair via nonhomologous end joining;non-recombinational repair;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;telomere maintenance Non-homologous end-joining 48 48 48 69.7 69.7 69.7 82.704 0 11976000000 6338400000 5637500000 3585 IPI:IPI00220834.8 ATP-dependent DNA helicase 2 subunit 2;ATP-dependent DNA helicase II 80 kDa subunit;Lupus Ku autoantigen protein p86;86 kDa subunit of Ku antigen;Ku86;Ku80;Thyroid-lupus autoantigen;CTC box-binding factor 85 kDa subunit;Nuclear factor IV;DNA repair protein XRCC5 XRCC5;G22P2 P13010 ENST00000328063 K10885 1 0.91707 2.282 0.88296 1.1342 1.5309 1.3514 Calpain_inhib binding;calcium-dependent cysteine-type endopeptidase inhibitor activity;cysteine-type endopeptidase inhibitor activity;endopeptidase inhibitor activity;enzyme inhibitor activity;enzyme regulator activity;peptidase inhibitor activity;protein binding 4 4 4 8.2 8.2 8.2 84.942 3.2038E-29 28122000 14886000 13236000 3587 IPI:IPI00761160.1;IPI:IPI00761035.1;IPI:IPI00760715.1;IPI:IPI00305750.4;IPI:IPI00220857.3;IPI:IPI00760909.2;IPI:IPI00220859.3 Calpastatin;Calpain inhibitor;Sperm BS-17 component CAST P20810-6;P20810;P20810-7;P20810-5;P20810-1;P20810-2;P20810-4;P20810-3 ENST00000325674;ENST00000341926;ENST00000361634;ENST00000395812;ENST00000395813 K04281 7 0.76053 1.1507 0.8868 0.95712 0.81702 1.0751 PID;TBC cell part;cytoplasm;intracellular part enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity;Rab GTPase activator activity;Ras GTPase activator activity;small GTPase regulator activity biological regulation;regulation of catalytic activity;regulation of GTPase activity;regulation of hydrolase activity;regulation of molecular function;regulation of Rab GTPase activity;regulation of Ras GTPase activity 7 6 6 9.7 8.9 8.9 146.6 1.819E-62 79603000 39178000 40424000 3588 IPI:IPI00220901.4;IPI:IPI00926460.1;IPI:IPI00926241.1;IPI:IPI00926985.1;IPI:IPI00926756.1 TBC1 domain family member 4;Akt substrate of 160 kDa TBC1D4;AS160;KIAA0603 O60343-1;O60343;O60343-3;O60343-2 ENST00000377636 5 0.50387 0.93416 0.49354 0.67859 0.61961 0.63421 BAH;DMAP_binding;DNA_methylase;zf-CXXC cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;DNA (cytosine-5-)-methyltransferase activity;DNA binding;methyltransferase activity;nucleic acid binding;protein binding;S-adenosylmethionine-dependent methyltransferase activity;transcription factor binding;zinc ion binding DNA alkylation;DNA metabolic process;DNA methylation;DNA modification;negative regulation of transcription from RNA polymerase II promoter;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription 40 40 40 25.9 25.9 25.9 184.82 0 1503100000 819820000 683330000 3589 IPI:IPI00220918.1;IPI:IPI00031519.3;IPI:IPI00220919.1 DNA (cytosine-5)-methyltransferase 1;MCMT;DNA methyltransferase HsaI;CXXC-type zinc finger protein 9 DNMT1;AIM;CXXC9;DNMT P26358-2;P26358;P26358-1;P26358-3 ENST00000340748;ENST00000359526 3 NaN 1.2862 NaN NaN 0.88401 NaN GRAM;Myotub-related cell part;membrane;plasma membrane catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;phosphatase activity;phosphoprotein phosphatase activity;phosphoric ester hydrolase activity;protein tyrosine phosphatase activity cellular metabolic process;cellular process;dephosphorylation;metabolic process;phosphate metabolic process;phosphorus metabolic process Aminosugars metabolism;Fructose and mannose metabolism;Riboflavin metabolism;Thiamine metabolism 3 3 2 5.6 5.6 3.6 74.677 6.7089E-16 2166900 1193000 973880 3590 IPI:IPI00292601.1;IPI:IPI00220956.2 Myotubularin-related protein 1 MTMR1 Q13613-1;Q13613;Q13613-2 ENST00000370390;ENST00000393954 K01112 2 0.7128 1.3423 0.70868 0.92592 0.85141 0.93193 CNPase cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;extracellular region part;extracellular space;intracellular membrane-bounded organelle;intracellular organelle;melanosome;membrane-bounded organelle;membrane-bounded vesicle;organelle;vesicle 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity;catalytic activity;cyclic-nucleotide phosphodiesterase activity;hydrolase activity;hydrolase activity, acting on ester bonds;phosphoric diester hydrolase activity;phosphoric ester hydrolase activity catabolic process;cell communication;cell-cell signaling;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;synaptic transmission 20 20 20 40.6 40.6 40.6 47.578 1.7604E-127 510790000 272820000 237970000 3591 IPI:IPI00306667.5;IPI:IPI00220993.1 2',3'-cyclic-nucleotide 3'-phosphodiesterase CNP P09543-1;P09543;P09543-2 ENST00000310262;ENST00000393892 K01121 2 0.67384 1.3476 0.69437 0.94517 0.91921 0.91511 NAC cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding;RNA polymerase II transcription factor activity;transcription regulator activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent 10 10 3 60.2 60.2 16 22.168 9.0946E-247 418790000 230820000 187970000 3593 IPI:IPI00221035.4;IPI:IPI00015946.1 Transcription factor BTF3;RNA polymerase B transcription factor 3 BTF3;NACB;OK/SW-cl.8 P20290-1;P20290 ENST00000335895;ENST00000380591 K01527 2 1.1327 1.6422 1.0522 1.3735 1.1761 1.2866 Y_phosphatase cell part;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part catalytic activity;hydrolase activity;phosphoprotein phosphatase activity;protein tyrosine phosphatase activity;receptor activity;signal transducer activity;transmembrane receptor activity;transmembrane receptor protein tyrosine phosphatase activity cellular process;dephosphorylation;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid dephosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process 3 3 3 4.3 4.3 4.3 91.92 7.2919E-14 7911900 3997800 3914100 3594 IPI:IPI00743698.2;IPI:IPI00843944.1;IPI:IPI00221067.1;IPI:IPI00304030.1 Receptor-type tyrosine-protein phosphatase alpha PTPRA;PTPA;PTPRL2 P18433-1;P18433;P18433-3;P18433-2;P18433-4 ENST00000216877;ENST00000356147;ENST00000358719;ENST00000380393;ENST00000399903 K01104 4 0.71718 1.3088 0.70191 0.93945 0.86964 0.91767 Ribosomal_S4;S4 cytosolic small ribosomal subunit;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nucleolus;organelle;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit binding;nucleic acid binding;protein binding;RNA binding;rRNA binding;structural constituent of ribosome;structural molecule activity;translation regulator activity biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;positive regulation of cell proliferation;translational elongation Ribosome 21 21 21 52.6 52.6 52.6 22.591 1.0758E-76 8993500000 5054000000 3939500000 3595 IPI:IPI00221088.5 40S ribosomal protein S9 RPS9 P46781 ENST00000302907;ENST00000391752;ENST00000391753 K02997 1 0.67845 1.4596 0.68851 0.90821 0.89513 0.94194 Ribosomal_S13_N;Ribosomal_S15 cytosolic small ribosomal subunit;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nucleolus;organelle;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit binding;mRNA binding;nucleic acid binding;protein binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;negative regulation of macromolecule metabolic process;negative regulation of metabolic process;regulation of gene expression;translational elongation Ribosome 14 14 14 55.6 55.6 55.6 17.222 3.8869E-214 5693300000 3083700000 2609600000 3596 IPI:IPI00221089.5 40S ribosomal protein S13 RPS13 P62277 ENST00000228140 K02953 1 0.72379 1.3606 0.69745 0.93976 0.90209 0.92079 Ribosomal_S8 cell part;cytoplasmic part;cytosolic part;cytosolic small ribosomal subunit;intracellular organelle part;intracellular part;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit binding;nucleic acid binding;protein binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;positive regulation of cell proliferation;response to biotic stimulus;response to virus;translational elongation Ribosome 11 11 11 63.8 63.8 63.8 14.839 2.2793E-185 6192700000 3379900000 2812700000 3597 IPI:IPI00221091.9 40S ribosomal protein S15a RPS15A;OK/SW-cl.82 P62244 ENST00000322989;ENST00000396261 K02957 1 0.7622 1.2976 0.70878 0.93621 0.89932 0.89991 Ribosomal_S9 cell part;cytoplasmic part;cytosolic part;cytosolic small ribosomal subunit;intracellular organelle part;intracellular part;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit binding;nucleic acid binding;protein binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA processing;rRNA processing;translational elongation Ribosome 15 15 15 60.3 60.3 60.3 16.445 7.8067E-48 5955700000 3142000000 2813800000 3598 IPI:IPI00221092.8 40S ribosomal protein S16 RPS16 P62249 ENST00000251453;ENST00000339471 K02960 1 0.64124 1.4009 0.68647 0.8969 0.87756 0.93684 Ribosomal_S17e cell part;cytoplasmic part;cytosolic part;cytosolic small ribosomal subunit;intracellular organelle part;intracellular part;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit structural constituent of ribosome;structural molecule activity biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA processing;rRNA processing;translational elongation;translational initiation 9 9 9 48.1 48.1 48.1 15.55 1.2917E-87 2439500000 1328000000 1111500000 3599 IPI:IPI00221093.7 40S ribosomal protein S17 RPS17 P08708 ENST00000330244;ENST00000330339 1 0.78787 1.6051 0.82128 1.0898 1.0361 1.0945 DUF382;PSP;SAP cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;protein binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 37 37 37 49.2 49.2 49.2 100.23 0 3617100000 1895800000 1721200000 3600 IPI:IPI00221106.5 Splicing factor 3B subunit 2;Pre-mRNA-splicing factor SF3b 145 kDa subunit;SF3b150;Spliceosome-associated protein 145 SF3B2;SAP145 Q13435 ENST00000322535 1 0.59504 1.0095 0.53611 0.80494 0.66805 0.71775 Thymidylat_synt cell part;cytoplasmic part;cytosol;intracellular part 5,10-methylenetetrahydrofolate-dependent methyltransferase activity;catalytic activity;methyltransferase activity;thymidylate synthase activity;transferase activity;transferase activity, transferring one-carbon groups alcohol metabolic process;carbohydrate metabolic process;D-ribose metabolic process;monosaccharide metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;pyrimidine nucleotide metabolic process One carbon pool by folate;Pyrimidine metabolism 14 14 14 53 53 53 35.716 0 1207100000 648710000 558420000 3601 IPI:IPI00221108.5 Thymidylate synthase TYMS;TS;OK/SW-cl.29 P04818 ENST00000323274 K00560 1 0.64736 1.2443 0.60026 0.80349 0.84583 0.75617 Acylphosphatase acylphosphatase activity;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides cellular metabolic process;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process Benzoate degradation via CoA ligation;Pyruvate metabolism 5 5 5 48.5 48.5 48.5 11.261 1.2359E-44 141760000 78149000 63608000 3602 IPI:IPI00221117.3 Acylphosphatase-1;Acylphosphate phosphohydrolase 1;Acylphosphatase, organ-common type isozyme;Acylphosphatase, erythrocyte isozyme ACYP1;ACYPE P07311 ENST00000238618 K01512 1 NaN 1.7328 0.88053 NaN 1.2636 1.0865 Pkinase cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part catalytic activity;MAP kinase activity;MAP kinase kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;receptor signaling protein serine/threonine kinase activity behavior;cell communication;cell motion;chemotaxis;intracellular signaling cascade;locomotory behavior;protein kinase cascade;Ras protein signal transduction;response to external stimulus;signal transduction;small GTPase mediated signal transduction Amyotrophic lateral sclerosis (ALS);Epithelial cell signaling in Helicobacter pylori infection;Fc epsilon RI signaling pathway;GnRH signaling pathway;Leukocyte transendothelial migration;MAPK signaling pathway;MAPK signaling pathway - yeast;Progesterone-mediated oocyte maturation;T cell receptor signaling pathway;Toll-like receptor signaling pathway;VEGF signaling pathway 15 1 1 51.7 3.3 3.3 41.493 0 18698000 8213300 10485000 3603 IPI:IPI00221141.3 Mitogen-activated protein kinase 14;Mitogen-activated protein kinase p38 alpha;Cytokine suppressive anti-inflammatory drug-binding protein;MAX-interacting protein 2;MAP kinase MXI2;SAPK2A MAPK14;CSBP;CSBP1;CSBP2;CSPB1;MXI2 Q16539-2;Q16539 ENST00000229794;ENST00000229795;ENST00000310795 K04441 1 0.83936 1.559 0.73363 1.1228 0.98023 1.0285 PHD;zf-UBR cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle acid-amino acid ligase activity;binding;catalytic activity;ion binding;ligase activity;ligase activity, forming carbon-nitrogen bonds;protein binding;small conjugating protein ligase activity;ubiquitin-protein ligase activity;zinc ion binding catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 6 6 6 18.1 18.1 18.1 47.998 2.8215E-57 137330000 69940000 67395000 3604 IPI:IPI00221172.2 Putative E3 ubiquitin-protein ligase UBR7;N-recognin-7 UBR7;C14orf130 Q8N806 ENST00000013070 1 1.1433 2.265 1.2412 1.4789 1.4959 1.6532 TPD52 binding;protein binding 10 10 2 53.1 53.1 6.2 22.517 8.4639E-176 799620000 368210000 431410000 3605 IPI:IPI00399266.1;IPI:IPI00399268.1;IPI:IPI00221178.1 Tumor protein D54;Tumor protein D52-like 2 TPD52L2 O43399-3;O43399;O43399-4;O43399-2 ENST00000217121;ENST00000346249;ENST00000348257 3 0.79753 1.6498 0.85823 1.0703 1.0387 1.1589 PC4 intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;protein complex;transcription factor complex binding;DNA binding;nucleic acid binding;protein binding;single-stranded DNA binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding;transcription regulator activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 9 9 9 47.2 47.2 47.2 14.395 3.347E-122 2290600000 1161700000 1128900000 3606 IPI:IPI00221222.7 Activated RNA polymerase II transcriptional coactivator p15;SUB1 homolog;Positive cofactor 4;p14 SUB1;PC4;RPO2TC1 P53999 ENST00000265073 1 1.3117 2.5354 1.3553 1.7285 1.6867 1.7786 Annexin cell part;cytoplasmic membrane-bounded vesicle;cytoplasmic part;cytoplasmic vesicle;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;melanosome;membrane-bounded organelle;membrane-bounded vesicle;organelle;vesicle binding;calcium ion binding;calcium-dependent phospholipid binding;cation binding;ion binding;lipid binding;metal ion binding;phospholipid binding;protein binding 58 58 58 69.1 69.1 69.1 75.872 0 14920000000 7240600000 7679500000 3607 IPI:IPI00221226.7 Annexin A6;Annexin-6;Annexin VI;Lipocortin VI;p68;p70;Protein III;Chromobindin-20;67 kDa calelectrin;Calphobindin-II ANXA6;ANX6 P08133 ENST00000354546 1 0.77187 1.3397 0.73781 1.0003 0.96658 0.93415 NUDIX binding;bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity;bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity;bis(5'-nucleosyl)-tetraphosphatase activity;catalytic activity;GTP binding;nucleotide binding;nucleotide diphosphatase activity cellular process;induction of apoptosis;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;positive regulation of cell death;regulation of cell death Purine metabolism;Pyrimidine metabolism 4 4 4 41.5 41.5 41.5 16.829 4.083E-105 129430000 69746000 59681000 3608 IPI:IPI00221231.3 Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical];Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase;Nucleoside diphosphate-linked moiety X motif 2 NUDT2;APAH1 P50583 ENST00000337747;ENST00000346365;ENST00000379154;ENST00000379155;ENST00000379158;ENST00000407581 K01518 1 0.80232 1.6736 0.83448 1.1048 1.0655 1.1295 Peptidase_M1 cell part;extracellular region;integral to membrane;integral to plasma membrane;intracellular;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part aminopeptidase activity;binding;catalytic activity;cation binding;exopeptidase activity;hydrolase activity;ion binding;metal ion binding;metallopeptidase activity;peptidase activity;transition metal ion binding;zinc ion binding catabolic process;cell communication;cell-cell signaling;cellular process;female pregnancy;macromolecule catabolic process;metabolic process;protein catabolic process;protein metabolic process;proteolysis;reproductive process Renin-angiotensin system 20 20 20 17.8 17.8 17.8 117.35 4.6243E-128 385380000 205320000 180070000 3609 IPI:IPI00307017.2;IPI:IPI00221240.3;IPI:IPI00221241.3 Leucyl-cystinyl aminopeptidase;Oxytocinase;Insulin-regulated membrane aminopeptidase;Insulin-responsive aminopeptidase;Placental leucine aminopeptidase;Leucyl-cystinyl aminopeptidase, pregnancy serum form LNPEP;OTASE Q9UIQ6-1;Q9UIQ6;Q9UIQ6-2;Q9UIQ6-3 ENST00000231368;ENST00000379870;ENST00000395770 K01257 3 NaN 1.6653 0.48535 NaN 1.1152 0.63984 Ank 3 3 3 3.1 3.1 3.1 155.86 5.8167E-06 2416300 1039700 1376600 3610 IPI:IPI00221285.5 Ankyrin repeat domain-containing protein 50 ANKRD50;KIAA1223 Q9ULJ7 ENST00000281131 1 0.78341 1.5918 0.76932 1.0403 1.0637 1.0244 IF-2B cell fraction;cell part;cytoplasmic part;eukaryotic translation initiation factor 2B complex;insoluble fraction;intracellular part;macromolecular complex;membrane;membrane fraction;plasma membrane;protein complex binding;nucleic acid binding;protein binding;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity response to abiotic stimulus;response to carbohydrate stimulus;response to endogenous stimulus;response to heat;response to hexose stimulus;response to hormone stimulus;response to stress;response to temperature stimulus;translational initiation 15 15 15 48.9 48.9 48.9 33.712 3.1778E-146 500220000 266290000 233940000 3611 IPI:IPI00221300.2 Translation initiation factor eIF-2B subunit alpha;eIF-2B GDP-GTP exchange factor subunit alpha EIF2B1;EIF2BA Q14232 ENST00000228958 K03239 1 0.64696 1.2617 0.68999 0.87489 0.83704 0.91309 Pro_isomerase;Ran_BP1;TPR_1;zf-RanBP cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;organelle part;pore complex;protein complex binding;catalytic activity;cation binding;cis-trans isomerase activity;enzyme binding;ion binding;isomerase activity;peptidyl-prolyl cis-trans isomerase activity;protein binding;Ran GTPase binding;Ras GTPase binding;small GTPase binding;zinc ion binding catabolic process;cellular process;intracellular protein transport;macromolecule catabolic process;metabolic process;nucleocytoplasmic transport;protein folding;protein import into nucleus;protein targeting;protein transport;proteolysis;transport 52 52 36 21.2 21.2 16.5 358.2 0 651830000 346340000 305490000 3613 IPI:IPI00221325.3;IPI:IPI00100787.2;IPI:IPI00879540.1 E3 SUMO-protein ligase RanBP2;Ran-binding protein 2;Nuclear pore complex protein Nup358;Nucleoporin Nup358;358 kDa nucleoporin;p270 RANBP2;NUP358 P49792 ENST00000283195 K12172 3 0.75926 1.3744 0.8474 1.0462 0.83632 1.2067 Dynamin_M;Dynamin_N;GED;PH cell part;cell projection part;cytoplasmic part;cytoskeletal part;dendritic spine;intracellular organelle part;intracellular part;microtubule;organelle part;perinuclear region of cytoplasm;postsynaptic density;synapse part binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;motor activity;nucleotide binding;protein binding;pyrophosphatase activity anatomical structure formation;cell projection organization;cellular component assembly;cellular component organization;cellular process;endocytosis;membrane invagination;membrane organization;synaptogenesis;transport;vesicle-mediated transport 8 2 2 7.9 1.8 1.8 98.247 1.3267E-43 9855300 4233100 5622200 3614 IPI:IPI00641436.3;IPI:IPI00895844.1;IPI:IPI00221332.8;IPI:IPI00480085.6 Dynamin-3;Dynamin, testicular;T-dynamin DNM3;KIAA0820 Q9UQ16-3;Q9UQ16;Q9UQ16-4;Q9UQ16-1;Q9UQ16-2 ENST00000355305;ENST00000358155 4 0.88605 1.6439 NaN 1.2266 1.031 NaN YTH 6 2 2 12.5 4.3 4.3 60.873 2.6897E-50 166620 96693 69923 3615 IPI:IPI00221345.1 YTH domain family protein 1;Dermatomyositis associated with cancer putative autoantigen 1 YTHDF1;C20orf21 Q9BYJ9-1;Q9BYJ9 ENST00000342761;ENST00000370333;ENST00000370339 1 0.78494 1.6299 0.82488 1.106 0.9891 1.1413 RRM_1;zf-RanBP cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;RNA binding;transition metal ion binding;zinc ion binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 11 11 9 18 18 18 53.376 0 3401600000 1761600000 1639900000 3616 IPI:IPI00260715.5;IPI:IPI00221354.1 RNA-binding protein FUS;Oncogene FUS;Oncogene TLS;Translocated in liposarcoma protein;POMp75;75 kDa DNA-pairing protein FUS;TLS P35637-1;P35637;P35637-2 ENST00000254108 2 0.55492 1.2663 0.57531 0.73736 0.81186 0.7754 DKCLD;PUA;TruB_N Cajal body;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nuclear body;nucleolus;organelle;organelle part;ribonucleoprotein complex;telomerase holoenzyme complex binding;catalytic activity;nucleic acid binding;protein binding;pseudouridine synthase activity;RNA binding;RNA-directed DNA polymerase activity;telomerase activity;transferase activity;transferase activity, transferring phosphorus-containing groups DNA metabolic process;DNA replication;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;pseudouridine synthesis;RNA processing;RNA-dependent DNA replication;rRNA processing;telomere maintenance 14 14 14 32.7 32.7 32.7 57.673 1.3192E-155 551630000 300480000 251150000 3617 IPI:IPI00221394.8 H/ACA ribonucleoprotein complex subunit 4;Dyskerin;Nucleolar protein family A member 4;snoRNP protein DKC1;Nopp140-associated protein of 57 kDa;Nucleolar protein NAP57;CBF5 homolog DKC1;NOLA4 O60832 ENST00000369550;ENST00000393535 K11131 1 0.65164 1.408 0.61363 0.90863 0.80064 0.84983 eIF-1a cell part;cytoplasm;cytoplasmic part;cytosol;intracellular part binding;nucleic acid binding;protein binding;RNA binding;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity cellular process;translational initiation 8 8 8 40.3 40.3 40.3 16.46 2.4587E-115 413570000 227840000 185740000 3618 IPI:IPI00232533.5;IPI:IPI00023004.7 Eukaryotic translation initiation factor 1A, X-chromosomal;eIF-1A X isoform;eIF-4C;Eukaryotic translation initiation factor 1A, Y-chromosomal;eIF-1A Y isoform EIF1AX;EIF1A;EIF4C;EIF1AY P47813;O14602 ENST00000379607;ENST00000361365 K03236 2 0.70027 1.3623 0.78172 0.9139 0.90663 0.99087 Myb_DNA-binding;SWIRM cell part;chromatin;chromatin remodeling complex;chromosomal part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex;SWI/SNF complex;SWI/SNF-type complex binding;chromatin binding;DNA binding;nucleic acid binding;protein binding;protein C-terminus binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding chromatin assembly or disassembly;chromatin organization;chromatin remodeling;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 33 33 23 30.2 30.2 24.1 122.87 0 1733700000 882890000 850790000 3619 IPI:IPI00234252.3 SWI/SNF complex subunit SMARCC1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1;SWI/SNF complex 155 kDa subunit;BRG1-associated factor 155 SMARCC1;BAF155 Q92922 ENST00000254480 K11649 1 0.61998 1.4693 0.82434 0.86765 0.95679 1.1062 PfkB adenosine kinase activity;ATP binding;binding;catalytic activity;kinase activity;magnesium ion binding;nucleoside binding;nucleotide binding;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside metabolic process;nucleoside phosphate metabolic process;purine ribonucleoside salvage Purine metabolism 9 9 9 22.7 22.7 22.7 40.545 1.8312E-50 102740000 56291000 46452000 3620 IPI:IPI00290279.1;IPI:IPI00234368.1 Adenosine kinase;Adenosine 5'-phosphotransferase ADK P55263-1;P55263;P55263-2 ENST00000286621;ENST00000372734 K00856 2 NaN 1.0302 NaN NaN 0.65191 NaN Pkinase cell part;cytoplasm;intracellular part ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity DNA metabolic process;DNA repair;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process Circadian rhythm - mammal;Gap junction;Hedgehog signaling pathway 3 1 1 10.3 3.7 3.7 46.832 1.1003E-06 1412900 594120 818810 3621 IPI:IPI00234463.4;IPI:IPI00011102.2 Casein kinase I isoform delta CSNK1D P48730-2;P48730;P48730-1 ENST00000314028;ENST00000392334;ENST00000403276 K08959 2 0.82765 1.7177 NaN 1.1344 1.1268 NaN Pkinase;Pkinase_C actin cytoskeleton;cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle actin binding;ATP binding;binding;catalytic activity;cytoskeletal protein binding;magnesium ion binding;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding cell communication;cellular process;intracellular signaling cascade;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein kinase cascade;protein modification process;signal transduction 10 8 8 21.8 19.4 19.4 54.002 2.9719E-46 27722000 15885000 11837000 3623 IPI:IPI00237011.5 Serine/threonine-protein kinase 38-like;NDR2 protein kinase;Nuclear Dbf2-related kinase 2 STK38L;KIAA0965;NDR2 Q9Y2H1 ENST00000389032 K08790 1 0.71056 1.5126 NaN 0.94823 0.98593 NaN E1-E2_ATPase cell part;integral to membrane;intrinsic to membrane;membrane part ATP binding;binding;catalytic activity;lipid transporter activity;magnesium ion binding;nucleoside binding;nucleotide binding;phospholipid transporter activity;phospholipid-translocating ATPase activity;purine nucleoside binding;transporter activity ATP biosynthetic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;transport 2 2 2 2.8 2.8 2.8 129.48 2.5003E-06 20397000 11535000 8862700 3624 IPI:IPI00396234.2;IPI:IPI00552319.2;IPI:IPI00555989.1;IPI:IPI00237446.7 Probable phospholipid-transporting ATPase IG;ATPase class VI type 11C;ATPase IG;ATPase IQ ATP11C;ATPIG;ATPIQ Q8NB49-1;Q8NB49;Q8NB49-4;Q8NB49-3;Q8NB49-2 ENST00000327569;ENST00000359686;ENST00000361648;ENST00000370543 K01530 4 0.66425 1.1113 0.62575 0.90501 0.71865 0.83922 CS 2 2 2 6.1 6.1 6.1 40.822 1.7589E-19 55298000 29590000 25708000 3625 IPI:IPI00238209.3 NudC domain-containing protein 3 NUDCD3;KIAA1068 Q8IVD9 ENST00000355451 1 0.48616 0.8706 0.3627 0.66169 0.56143 0.45838 IQ;LRR_1 centrosome;cytoplasmic part;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;microtubule organizing center;non-membrane-bounded organelle;organelle;organelle part binding;protein binding 4 4 4 6.2 6.2 6.2 99.907 1.2695E-33 9341300 5737000 3604300 3626 IPI:IPI00238469.6;IPI:IPI00383439.2 Centrosomal protein of 97 kDa;Leucine-rich repeat and IQ domain-containing protein 2 CEP97;LRRIQ2 Q8IW35-2;Q8IW35;Q8IW35-1 ENST00000341893 2 0.82916 1.763 0.8697 1.0739 1.1367 1.132 HIT cell part;cytoplasm;cytoskeleton;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle binding;catalytic activity;enzyme binding;hydrolase activity;kinase binding;protein binding;protein kinase binding;protein kinase C binding biological regulation;cell communication;cellular process;regulation of biological process;regulation of cellular process;signal transduction 14 14 14 92.1 92.1 92.1 13.802 1.4895E-213 2807600000 1463400000 1344200000 3627 IPI:IPI00239077.5 Histidine triad nucleotide-binding protein 1;Adenosine 5'-monophosphoramidase;Protein kinase C inhibitor 1;Protein kinase C-interacting protein 1 HINT1;HINT;PKCI1;PRKCNH1 P49773 ENST00000304043 1 0.7271 1.6112 0.53729 0.97947 1.006 0.76305 CH;KASH;Spectrin cytoplasm;cytoskeleton;integral to membrane;intracellular organelle;intrinsic to membrane;membrane;non-membrane-bounded organelle;nuclear membrane;nuclear outer membrane;organelle;organelle membrane;organelle outer membrane;outer membrane actin binding;binding;cytoskeletal protein binding;protein binding 11 11 10 1.8 1.8 1.6 798.85 3.4341E-64 19900000 10804000 9096700 3628 IPI:IPI00239406.2;IPI:IPI00239405.4;IPI:IPI00239413.4;IPI:IPI00815967.1;IPI:IPI00239409.1 Nesprin-2;Nuclear envelope spectrin repeat protein 2;Synaptic nuclear envelope protein 2;Nucleus and actin connecting element protein SYNE2;KIAA1011;NUA Q8WXH0-2;Q8WXH0;Q8WXH0-1;Q8WXH0-7 ENST00000261678;ENST00000341472;ENST00000344113;ENST00000356081;ENST00000357395;ENST00000358025 5 0.45416 0.74546 0.44629 0.59121 0.52334 0.58081 WD40 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part 13 13 13 26.4 26.4 26.4 76.889 8.16E-120 220790000 121840000 98948000 3629 IPI:IPI00239815.9;IPI:IPI00399197.1;IPI:IPI00399195.1 Cirhin CIRH1A;KIAA1988 Q969X6-1;Q969X6;Q969X6-3;Q969X6-2 ENST00000314423;ENST00000352319 3 1.2441 2.0675 1.1839 1.6379 1.3783 1.4748 E1-E2_ATPase;Hydrolase cell part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;nuclear inner membrane;nuclear membrane;nuclear part;organelle inner membrane;organelle membrane;organelle part ATP binding;binding;catalytic activity;lipid transporter activity;magnesium ion binding;nucleoside binding;nucleotide binding;phospholipid transporter activity;phospholipid-translocating ATPase activity;purine nucleoside binding;transporter activity ATP biosynthetic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;transport 4 4 4 4.8 4.8 4.8 134.19 3.7304E-07 9074500 4768000 4306400 3630 IPI:IPI00240793.1 Probable phospholipid-transporting ATPase IF;ATPase class VI type 11B;ATPase IR ATP11B;ATPIF;ATPIR;KIAA0956 Q9Y2G3 ENST00000323116 K01530 1 0.55738 1.2818 0.603 0.76307 0.82659 0.80483 Peptidase_M3 cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part binding;calcium ion binding;catalytic activity;endopeptidase activity;hydrolase activity;ion binding;iron ion binding;magnesium ion binding;manganese ion binding;metalloendopeptidase activity;metallopeptidase activity;peptidase activity;zinc ion binding catabolic process;macromolecule catabolic process;metabolic process;mitochondrial protein processing;mitochondrial protein processing during import;protein catabolic process;protein metabolic process;protein processing;proteolysis 8 8 8 12.8 12.8 12.8 80.64 3.5124E-16 66783000 38101000 28681000 3631 IPI:IPI00241860.4 Mitochondrial intermediate peptidase MIPEP;MIP Q99797 ENST00000382172 K01410 1 0.60511 1.2312 0.62157 0.7513 0.8335 0.8017 HEAT binding;protein binding 15 15 15 21.9 21.9 21.9 93.492 1.5247E-157 211410000 115700000 95710000 3632 IPI:IPI00242630.4;IPI:IPI00654611.2;IPI:IPI00784196.3 HEAT repeat-containing protein 2 HEATR2 Q86Y56-1;Q86Y56;Q86Y56-2;Q86Y56-3 ENST00000297440;ENST00000313147 3 0.72409 1.227 0.70002 0.97941 0.78657 0.95287 RNase_H2-Ydr279 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle DNA replication 11 11 11 36.9 36.9 36.9 37.359 2.5673E-122 402790000 207040000 195760000 3633 IPI:IPI00245135.1 Ribonuclease H2 subunit B;Ribonuclease HI subunit B;Aicardi-Goutieres syndrome 2 protein;Deleted in lymphocytic leukemia 8 RNASEH2B;DLEU8 Q5TBB1 ENST00000336617 K10744 1 0.91132 1.6154 0.88761 1.172 1.0663 1.1891 BRO1 centrosome;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;cytosol;intracellular organelle;melanosome;membrane-bounded organelle;membrane-bounded vesicle;microtubule organizing center;non-membrane-bounded organelle;organelle;vesicle binding;protein binding apoptosis;cell cycle;cell death;cell division;cellular process;death;establishment of localization;establishment of protein localization;interspecies interaction between organisms;multi-organism process;programmed cell death;protein transport;transport 30 30 30 37.6 37.6 37.6 96.022 0 1655200000 842050000 813170000 3634 IPI:IPI00246058.10 Programmed cell death 6-interacting protein;ALG-2-interacting protein 1;Hp95 PDCD6IP;AIP1;ALIX;KIAA1375 Q8WUM4 ENST00000307296 K12200 1 0.77914 1.4681 0.77572 1.0537 0.96506 1.0409 GST_C;GST_N cell part;cytoplasm;intracellular part binding;catalytic activity;glutathione transferase activity;protein binding;transferase activity;transferase activity, transferring alkyl or aryl (other than methyl) groups cellular process;developmental process;endothelial cell development;establishment of blood-nerve barrier;metabolic process;response to chemical stimulus;response to endogenous stimulus;response to hormone stimulus;response to organic substance Drug metabolism - cytochrome P450;Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450 14 14 13 64.4 64.4 60.4 26.559 2.0944E-122 399380000 211800000 187570000 3635 IPI:IPI00246975.8 Glutathione S-transferase Mu 3;GSTM3-3;GST class-mu 3 GSTM3;GST5 P21266 ENST00000256594;ENST00000361066 K00799 1 NaN 3.0402 NaN NaN 2.062 NaN FBA binding;protein binding biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process 2 2 2 7.6 7.6 7.6 30.847 0.0012127 284950 261940 23009 3636 IPI:IPI00247167.3 Non-specific cytotoxic cell receptor protein 1 homolog NCCRP1 Q6ZVX7 ENST00000339852 1 0.90211 1.4118 0.49786 1.1289 0.94621 0.75305 CH;KASH;Spectrin cytoskeleton;Golgi apparatus;integral to membrane;intrinsic to membrane;membrane;membrane-bounded organelle;nuclear membrane;nuclear outer membrane;organelle;organelle membrane;organelle outer membrane;outer membrane;sarcomere actin binding;binding;cytoskeletal protein binding;lamin binding;protein binding cell death;cell differentiation;cellular component organization;cellular developmental process;cellular process;death;developmental process;Golgi organization;muscle cell differentiation;nucleus organization;organelle organization 10 9 9 1.4 1.3 1.3 1011 3.1954E-33 120180000 64347000 55836000 3637 IPI:IPI00386444.3;IPI:IPI00247295.4;IPI:IPI00647370.2;IPI:IPI00943590.1;IPI:IPI00940636.2;IPI:IPI00247296.2;IPI:IPI00396977.2;IPI:IPI00170463.2;IPI:IPI00247300.4 Nesprin-1;Nuclear envelope spectrin repeat protein 1;Synaptic nuclear envelope protein 1;Myocyte nuclear envelope protein 1 SYNE1;KIAA0796;KIAA1262;KIAA1756;MYNE1 Q8NF91-1;Q8NF91;Q8NF91-4;Q8NF91-6;Q8NF91-2;Q8NF91-8 ENST00000265368;ENST00000341594;ENST00000347037;ENST00000356820;ENST00000367255;ENST00000367257 9 0.81585 1.554 0.67262 1.0669 1.0537 0.87079 RHD;TIG cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;protein binding;transcription activator activity;transcription factor activity;transcription regulator activity biosynthetic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription 9 9 9 12.8 12.8 12.8 100.14 2.1374E-91 26523000 14231000 12292000 3638 IPI:IPI00297845.4;IPI:IPI00247309.3 Nuclear factor of activated T-cells, cytoplasmic 2;T-cell transcription factor NFAT1;NFAT pre-existing subunit NFATC2;NFAT1;NFATP Q13469-1;Q13469;Q13469-2 ENST00000371564;ENST00000396009 2 0.75574 1.3746 0.68928 0.95483 0.9315 0.94494 Ribosomal_L21e cell part;cytoplasmic part;cytosolic large ribosomal subunit;cytosolic part;intracellular organelle part;intracellular part;large ribosomal subunit;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit binding;nucleic acid binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 9 9 9 45 45 45 18.565 2.1977E-141 4495100000 2376500000 2118700000 3639 IPI:IPI00247583.5 60S ribosomal protein L21 RPL21 P46778 ENST00000272274;ENST00000311549;ENST00000319826;ENST00000326092 K02889 1 0.79329 1.5096 0.79129 1.0304 0.97858 1.0378 FF;WW cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding;RNA polymerase II transcription factor activity;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding;transcription regulator activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent 33 33 31 28.1 28.1 26.6 123.9 0 1739500000 890500000 849000000 3640 IPI:IPI00247871.2;IPI:IPI00744062.1 Transcription elongation regulator 1;TATA box-binding protein-associated factor 2S;Transcription factor CA150 TCERG1;CA150;TAF2S O14776-1;O14776;O14776-2 ENST00000296702;ENST00000394421 2 0.71803 1.7173 0.68607 1.0383 0.97014 0.96313 Maf;Methyltransf_2 cell part;cytoplasm;intracellular part acetylserotonin O-methyltransferase activity;catalytic activity;methyltransferase activity;O-methyltransferase activity;S-adenosylmethionine-dependent methyltransferase activity;transferase activity;transferase activity, transferring one-carbon groups biogenic amine metabolic process;cellular amino acid and derivative metabolic process;cellular amino acid derivative metabolic process;cellular aromatic compound metabolic process;indolalkylamine metabolic process;nitrogen compound metabolic process 8 8 8 18.8 18.8 18.8 68.856 1.2385E-108 36053000 20322000 15731000 3641 IPI:IPI00479385.4;IPI:IPI00249080.2 N-acetylserotonin O-methyltransferase-like protein ASMTL O95671-1;O95671;O95671-2 ENST00000381317;ENST00000381333 2 0.76223 NaN NaN 0.96974 NaN NaN centrosome;cytoplasmic part;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;microtubule organizing center;non-membrane-bounded organelle;organelle;organelle part 3 3 3 4.8 4.8 4.8 80.073 3.6403E-11 9146100 5125700 4020400 3642 IPI:IPI00249529.4;IPI:IPI00640133.6;IPI:IPI00647080.2;IPI:IPI00942857.1 Centrosomal protein of 78 kDa CEP78;C9orf81 Q5JTW2-2;Q5JTW2;Q5JTW2-4;Q5JTW2-3;Q5JTW2-1 ENST00000277082;ENST00000376598 4 0.73199 1.5069 0.83395 1.2273 0.97127 1.1339 CSD cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;RNA binding nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;regulation of translation;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent 9 3 3 19.2 12.4 12.4 38.517 1.1747E-127 61417000 31639000 29777000 3643 IPI:IPI00250153.8 Y-box-binding protein 2;Germ cell-specific Y-box-binding protein;Contrin;MSY2 homolog;DNA-binding protein C YBX2;CSDA3;MSY2 Q9Y2T7 ENST00000007699 K09277 1 0.67282 1.1589 0.60749 0.88016 0.80832 0.79982 ACPS cell part;cytoplasmic part;cytosol;intracellular part binding;catalytic activity;holo-[acyl-carrier-protein] synthase activity;magnesium ion binding;phosphotransferase activity, for other substituted phosphate groups;transferase activity;transferase activity, transferring phosphorus-containing groups biosynthetic process;macromolecule biosynthetic process;macromolecule metabolic process;metabolic process Lysine biosynthesis;Lysine degradation 13 13 13 40.5 40.5 40.5 35.776 6.6304E-160 487500000 262360000 225140000 3644 IPI:IPI00250297.3 L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase;4'-phosphopantetheinyl transferase;Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase;LYS5 ortholog AASDHPPT;CGI-80;HAH-P;HSPC223;x0005 Q9NRN7 ENST00000278618 K00142 1 0.77216 1.6733 0.77329 1.0515 1.1023 1.0212 zf-C3HC4 cell part;chromosome;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle binding;catalytic activity;cation binding;ion binding;ligase activity;metal ion binding;protein binding;transition metal ion binding;zinc ion binding catabolic process;cellular component organization;cellular process;chromatin modification;chromatin organization;macromolecule catabolic process;metabolic process;organelle organization;protein metabolic process;proteolysis 23 23 22 26.5 26.5 25.1 113.98 0 221370000 113990000 107390000 3645 IPI:IPI00251559.8 E3 ubiquitin-protein ligase BRE1A;RING finger protein 20 RNF20;BRE1A Q5VTR2 ENST00000374819;ENST00000389120 K10696 1 0.86948 1.6459 0.90206 1.1903 1.1036 1.2249 cell part;cytoplasm;integral to membrane;integral to plasma membrane;intracellular part;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part binding;protein binding biological adhesion;cell adhesion;cellular process Cell adhesion molecules (CAMs);Leukocyte transendothelial migration 3 3 3 10.3 10.3 10.3 18.848 4.7645E-101 203860000 99381000 104480000 3646 IPI:IPI00253036.5 CD99 antigen;T-cell surface glycoprotein E2;E2 antigen;Protein MIC2;12E7 CD99;MIC2;MIC2X;MIC2Y P14209-1;P14209 ENST00000381192;ENST00000398818 K06520 1 NaN 1.0147 NaN NaN 0.70947 NaN RRM_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;nucleotide binding;RNA binding cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 2 1 1 4 2.9 2.9 59.62 5.1063E-46 145440 74921 70520 3647 IPI:IPI00254162.2;IPI:IPI00641664.1;IPI:IPI00647067.1;IPI:IPI00514064.1;IPI:IPI00743676.1;IPI:IPI00748295.1 Polypyrimidine tract-binding protein 2;Neurally-enriched homolog of PTB;Neural polypyrimidine tract-binding protein;PTB-like protein PTBP2;NPTB;PTB;PTBLP Q9UKA9-3;Q9UKA9;Q9UKA9-4;Q9UKA9-2;Q9UKA9-1;Q9UKA9-6;Q9UKA9-5 ENST00000370194;ENST00000370197 6 NaN 2.4141 1.3786 NaN 1.6941 1.7616 cell part;integral to membrane;intrinsic to membrane;membrane part 3 3 3 7.7 7.7 7.7 51.396 7.6777E-61 27115000 11703000 15412000 3648 IPI:IPI00254338.2 Protein FAM134C FAM134C Q86VR2 ENST00000309428 1 0.60444 1.0155 NaN 0.82148 0.63229 NaN Bromodomain;DDT;FYDLN_acid;PHD cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;sequence-specific DNA binding;transcription factor binding;transcription regulator activity;transition metal ion binding;zinc ion binding chromatin organization;chromatin remodeling;negative regulation of transcription from RNA polymerase II promoter;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 4 4 4 1.5 1.5 1.5 338.26 8.4856E-15 3052300 1382500 1669800 3649 IPI:IPI00785110.2;IPI:IPI00254408.6;IPI:IPI00376404.3 Nucleosome-remodeling factor subunit BPTF;Bromodomain and PHD finger-containing transcription factor;Fetal Alzheimer antigen;Fetal Alz-50 clone 1 protein BPTF;FAC1;FALZ Q12830-1;Q12830;Q12830-2;Q12830-4 ENST00000306378;ENST00000321892;ENST00000335221 K11728 3 0.55517 0.85387 0.50732 0.7097 0.59853 0.62423 cell part;chromosomal part;intracellular organelle part;intracellular part;macromolecular complex;nuclear chromosome part;nuclear part;nuclear telomere cap complex;nucleoplasm;organelle part;protein-DNA complex;telomere cap complex binding;DNA binding;DNA polymerase binding;enzyme binding;nucleic acid binding;protein binding DNA metabolic process;intracellular protein transport;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of DNA replication;response to stress;telomere maintenance;transport 2 2 2 4.2 4.2 4.2 57.758 2.2832E-08 13515000 7398300 6117100 3650 IPI:IPI00254484.3;IPI:IPI00639852.4 Adrenocortical dysplasia protein homolog;POT1 and TIN2-interacting protein ACD;PIP1;PTOP;TINT1;TPP1 Q96AP0-1;Q96AP0;Q96AP0-2 ENST00000219251;ENST00000393919 K11114 2 0.85772 1.6283 0.80266 1.0953 1.0996 0.97318 Complex1_LYR cytoplasmic part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;mitochondrial membrane part;mitochondrial part;mitochondrial respiratory chain complex I;NADH dehydrogenase complex;organelle part;protein complex catalytic activity;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor cellular process;electron transport chain;generation of precursor metabolites and energy;metabolic process;mitochondrial electron transport, NADH to ubiquinone;sensory perception;sensory perception of sound;system process;transport Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 10 10 10 68.7 68.7 68.7 21.831 4.6855E-79 419330000 217310000 202020000 3651 IPI:IPI00255052.5 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9;NADH-ubiquinone oxidoreductase B22 subunit;Complex I-B22;LYR motif-containing protein 3 NDUFB9;LYRM3;UQOR22 Q9Y6M9 ENST00000276689 K03965 1 0.8915 1.5526 0.86405 1.1088 0.99954 1.1521 WW cell part;intracellular organelle part;intracellular part;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part binding;protein binding 6 6 6 14.8 14.8 14.8 70.723 1.8517E-109 34308000 18013000 16295000 3652 IPI:IPI00256605.5;IPI:IPI00478665.2;IPI:IPI00087375.2;IPI:IPI00152381.2;IPI:IPI00793965.1 WW domain-containing adapter protein with coiled-coil WAC;KIAA1844 Q9BTA9-1;Q9BTA9;Q9BTA9-2;Q9BTA9-5;Q9BTA9-3 ENST00000345541;ENST00000347934;ENST00000354911;ENST00000375664 5 0.70162 1.3047 0.73643 0.9358 0.89164 0.9422 Adaptin_N;Alpha_adaptin_C;Alpha_adaptinC2 AP-2 adaptor complex;AP-type membrane coat adaptor complex;clathrin adaptor complex;clathrin coat;clathrin coat of trans-Golgi network vesicle;clathrin vesicle coat;cytosol;macromolecular complex;membrane coat;organelle part;protein complex;vesicle coat protein transporter activity;substrate-specific transporter activity;transporter activity cellular process;endocytosis;Golgi to endosome transport;intracellular protein transport;post-Golgi vesicle-mediated transport;regulation of immune effector process;regulation of immune system process;regulation of response to biotic stimulus;transport 30 30 22 36.4 36.4 25.7 107.54 0 723090000 387200000 335880000 3653 IPI:IPI00304577.4;IPI:IPI00256684.2 AP-2 complex subunit alpha-1;Adapter-related protein complex 2 alpha-1 subunit;Adaptor protein complex AP-2 subunit alpha-1;Alpha1-adaptin;Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit;Alpha-adaptin A;Clathrin assembly protein complex 2 alpha-A large chain;100 kDa coated vesicle protein A AP2A1;ADTAA;CLAPA1 O95782-1;O95782;O95782-2 ENST00000354293;ENST00000359032 2 0.69851 1.3929 0.69705 0.95396 0.90454 0.88838 CH;efhand;GAS2;Spectrin cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle actin binding;actin filament binding;binding;calcium ion binding;cation binding;cytoskeletal protein binding;ion binding;metal ion binding;microtubule binding;protein binding;tubulin binding cell cycle arrest;cell cycle process;cellular process 49 49 12 11 11 2.5 620.41 0 851980000 465830000 386150000 3654 IPI:IPI00256861.4;IPI:IPI00550385.2;IPI:IPI00478226.1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5;Actin cross-linking family protein 7;Macrophin-1;Trabeculin-alpha;620 kDa actin-binding protein;ABP620 MACF1;ABP620;ACF7;KIAA0465;KIAA1251 Q9UPN3-2;Q9UPN3;Q9UPN3-1;Q9UPN3-4 ENST00000289893;ENST00000317713;ENST00000361689;ENST00000372925 3 0.58373 NaN 0.62846 0.75814 NaN 0.84204 endoplasmic reticulum membrane;integral to membrane;intracellular part;intrinsic to membrane;membrane;mitochondrial membrane;mitochondrial outer membrane;organelle membrane;organelle outer membrane;organelle part;outer membrane;plasma membrane apoptosis;cell death;cellular process;death;defense response;immune response;immune system process;innate immune response;programmed cell death;response to stimulus;response to stress 3 3 3 10 10 10 42.192 5.8069E-17 6579100 3431600 3147500 3655 IPI:IPI00257059.2 Transmembrane protein 173;Stimulator of interferon genes protein;Mediator of IRF3 activation TMEM173;MITA;STING Q86WV6 ENST00000330794 1 1.0809 1.8121 1.0803 1.4013 1.237 1.3468 Amidohydro_1 cell part;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle binding;catalytic activity;dihydropyrimidinase activity;hydrolase activity;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides;protein binding cell communication;cell differentiation;cellular process;developmental process;metabolic process;nervous system development;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;signal transduction Axon guidance 23 23 8 54.9 54.9 16.8 62.293 0 3104500000 1576900000 1527600000 3656 IPI:IPI00257508.4 Dihydropyrimidinase-related protein 2;Collapsin response mediator protein 2;N2A3 DPYSL2;CRMP2 Q16555 ENST00000311151 K07528 1 0.84805 1.4547 0.83986 1.0491 1.0002 1.0492 AMP_N;Peptidase_M24 aminopeptidase activity;binding;carboxypeptidase activity;catalytic activity;dipeptidase activity;exopeptidase activity;hydrolase activity;metallocarboxypeptidase activity;metalloexopeptidase activity;metallopeptidase activity;peptidase activity catabolic process;cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;macromolecule catabolic process;metabolic process;nitrogen compound metabolic process;organic acid metabolic process;proteolysis 14 14 14 33.7 33.7 33.7 54.548 3.3391E-162 644370000 332280000 312090000 3657 IPI:IPI00257882.7 Xaa-Pro dipeptidase;Proline dipeptidase;Imidodipeptidase;Peptidase D PEPD;PRD P12955 ENST00000244137 K01271 1 1.2027 2.1827 1.1163 1.5645 1.5287 1.4176 Ependymin extracellular region binding;calcium ion binding;cation binding;ion binding;metal ion binding biological adhesion;cell adhesion;cell-matrix adhesion;cell-substrate adhesion;cellular process 4 4 4 11.9 11.9 11.9 38.15 1.2629E-42 105860000 54144000 51711000 3658 IPI:IPI00657648.1;IPI:IPI00259102.2 Mammalian ependymin-related protein 1;Upregulated in colorectal cancer gene 1 protein EPDR1;MERP1;UCC1 Q9UM22-2;Q9UM22;Q9UM22-1 ENST00000199448 2 0.79577 1.5512 0.60752 0.95434 1.1065 0.80788 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-oxygen bonds;nucleoside binding;nucleotide binding;purine nucleoside binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription;translation 11 11 11 21.2 21.2 21.2 65.536 6.9119E-38 167630000 89582000 78052000 3659 IPI:IPI00288941.1 Nuclear receptor coactivator 5;Coactivator independent of AF-2 NCOA5;KIAA1637 Q9HCD5 ENST00000290231 1 0.6673 1.3129 0.72254 0.88346 0.89046 0.94278 G-alpha cell part;cytoplasm;intracellular part;membrane;plasma membrane binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;pyrophosphatase activity;signal transducer activity blood coagulation;cellular biopolymer metabolic process;cellular process;hemostasis;metabolic process;multicellular organismal process;protein amino acid ADP-ribosylation;protein metabolic process;protein modification process 8 8 8 30.6 30.6 30.6 42.142 1.1385E-132 85390000 46588000 38802000 3660 IPI:IPI00288947.3;IPI:IPI00305551.3;IPI:IPI00000695.1 Guanine nucleotide-binding protein G(q) subunit alpha;Guanine nucleotide-binding protein alpha-q GNAQ;GAQ P50148 ENST00000286548 3 0.78768 1.631 0.82411 1.0156 1.0654 1.1037 RAI16-like 7 7 7 11.1 11.1 11.1 86.557 1.8685E-61 49302000 27284000 22018000 3661 IPI:IPI00289031.5;IPI:IPI00639970.3 UPF0518 protein FAM160B1 FAM160B1;KIAA1600 Q5W0V3-1;Q5W0V3;Q5W0V3-2 ENST00000369248;ENST00000369250 2 NaN 1.3437 NaN NaN 0.8375 NaN FAST_1;FAST_2;RAP ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups apoptosis;cell death;cellular process;death;programmed cell death 3 3 3 4.5 4.5 4.5 97.41 6.2206E-25 1811700 959080 852580 3662 IPI:IPI00300186.6;IPI:IPI00289061.7 FAST kinase domain-containing protein 1 FASTKD1;KIAA1800 Q53R41-1;Q53R41;Q53R41-2 ENST00000260971;ENST00000361819 2 0.61866 1.5067 0.73168 0.83376 0.95242 0.98664 Rsm22 intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;mitochondrion;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome binding;catalytic activity;cation binding;copper ion binding;ion binding;metal ion binding;methyltransferase activity;transferase activity;transferase activity, transferring one-carbon groups;transition metal ion binding biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 3 3 3 8.6 8.6 8.6 53.051 3.7013E-09 10630000 6026700 4603300 3663 IPI:IPI00289084.6;IPI:IPI00329663.8;IPI:IPI00876996.1 Protein RSM22 homolog, mitochondrial;Methyltransferase 11 domain-containing protein 1;False p73 target gene protein METT11D1 Q9H7H0-3;Q9H7H0;Q9H7H0-1;Q9H7H0-2 ENST00000339374;ENST00000382985 3 0.51491 1.3525 NaN 0.69982 0.88963 NaN LRR_1;SAM_2 cell part;cytoplasm;extracellular region;intracellular part binding;catalytic activity;cation binding;hormone activity;ion binding;ligase activity;metal ion binding;protein binding;receptor binding;transition metal ion binding;zinc ion binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;protein transport;proteolysis;transport 5 5 5 8.6 8.6 8.6 83.593 5.7694E-63 5412300 2956100 2456200 3664 IPI:IPI00300805.4;IPI:IPI00289113.4 E3 ubiquitin-protein ligase LRSAM1;Leucine-rich repeat and sterile alpha motif-containing protein 1;Tsg101-associated ligase LRSAM1;TAL;UNQ6496/PRO21356 Q6UWE0-1;Q6UWE0;Q6UWE0-2 ENST00000300417;ENST00000323301;ENST00000373322;ENST00000373324 K10641 2 0.51004 1.2714 NaN 0.68038 0.80571 NaN Ank;Glutaminase cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part catalytic activity;glutaminase activity;hydrolase activity;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides catabolic process;cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;glutamine catabolic process;glutamine metabolic process;metabolic process;nitrogen compound metabolic process;organic acid metabolic process Arginine and proline metabolism;D-Glutamine and D-glutamate metabolism;Glutamate metabolism;Nitrogen metabolism 19 3 3 35.3 5.1 5.1 73.46 5.0677E-286 10704000 6103100 4600700 3665 IPI:IPI00289159.3 Glutaminase kidney isoform, mitochondrial;L-glutamine amidohydrolase;K-glutaminase GLS;GLS1;KIAA0838 O94925-1;O94925 ENST00000320717;ENST00000338435 K01425 1 0.84488 1.4649 1.0226 1.0908 1.0249 1.2526 Myb_DNA-binding cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding;transcription cofactor activity;transcription corepressor activity;transcription factor binding;transcription regulator activity;transcription repressor activity chromatin organization;negative regulation of transcription from RNA polymerase II promoter;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription;transcription, DNA-dependent 11 11 11 6.1 6.1 6.1 270.21 2.9398E-148 73663000 37211000 36452000 3666 IPI:IPI00289344.4;IPI:IPI00939364.1 Nuclear receptor corepressor 1 NCOR1;KIAA1047 O75376-1;O75376;O75376-2 ENST00000268712;ENST00000395857 K04650 2 0.29291 NaN NaN 0.38254 NaN NaN Pkinase autophagic vacuole;cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle;vacuole ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity macromolecule localization;protein localization;regulation of autophagy;regulation of biological process;regulation of catabolic process;regulation of cellular catabolic process;regulation of cellular metabolic process;regulation of metabolic process mTOR signaling pathway;Regulation of autophagy 2 2 2 1.9 1.9 1.9 112.6 0.0016928 37076 29770 7305.5 3667 IPI:IPI00289357.4 Serine/threonine-protein kinase ULK1;Unc-51-like kinase 1 ULK1;KIAA0722 O75385 ENST00000321867 K08269 1 1.3343 2.3051 NaN 1.6891 1.4694 NaN MoaC;Mob_synth_C;Radical_SAM cell part;macromolecular complex;molybdopterin synthase complex;protein complex binding;catalytic activity;cation binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;ion binding;iron ion binding;metal ion binding;nucleotide binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding biosynthetic process;cellular aromatic compound metabolic process;cellular process;coenzyme biosynthetic process;coenzyme metabolic process;metabolic process;Mo-molybdopterin cofactor biosynthetic process;nitrogen compound metabolic process 5 5 5 10.5 10.5 10.5 70.104 4.6977E-61 5301300 2514000 2787200 3668 IPI:IPI00289462.1;IPI:IPI00925345.1;IPI:IPI00289463.1;IPI:IPI00746947.2;IPI:IPI00180672.1;IPI:IPI00232406.1;IPI:IPI00413557.1;IPI:IPI00926940.1 Molybdenum cofactor biosynthesis protein 1;Molybdenum cofactor synthesis-step 1 protein A-B;Migration-inducing gene 11 protein;Molybdenum cofactor biosynthesis protein A;Molybdenum cofactor biosynthesis protein C MOCS1;MIG11 Q9NZB8-1;Q9NZB8;Q9NZB8-8;Q9NZB8-2;Q9NZB8-7;Q9NZB8-6;Q9NZB8-5;Q9NZB8-3;Q9NZB8-4 ENST00000340692;ENST00000373181 8 0.74749 1.4379 0.76239 0.98768 0.96571 0.97744 AICARFT_IMPCHas;MGS binding;catalytic activity;glycine hydroxymethyltransferase activity;IMP cyclohydrolase activity;methyltransferase activity;phosphoribosylaminoimidazolecarboxamide formyltransferase activity;protein binding;transferase activity IMP biosynthetic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process One carbon pool by folate;Purine metabolism 40 40 40 82.1 82.1 82.1 64.615 0 8816400000 4755500000 4061000000 3669 IPI:IPI00289499.3 Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase;AICAR transformylase;IMP cyclohydrolase;Inosinicase;IMP synthetase;ATIC ATIC;PURH;OK/SW-cl.86 P31939 ENST00000236959 K00602 1 0.83725 1.4612 0.80926 1.0758 0.96005 1.0662 PH;SH3_1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;nucleus;organelle;plasma membrane binding;catalytic activity;kinase activity;protein binding;protein kinase activity;protein tyrosine kinase activity;SH3/SH2 adaptor activity;signal transducer activity;transferase activity;transferase activity, transferring phosphorus-containing groups biological regulation;cell communication;cellular process;immune response;immune system process;regulation of biological process;regulation of cellular process;response to stimulus;signal transduction 3 3 3 9.2 9.2 9.2 41.432 2.2096E-32 66733000 34489000 32244000 3670 IPI:IPI00289536.7;IPI:IPI00793789.3 Src kinase-associated phosphoprotein 1;Src family-associated phosphoprotein 1;Src kinase-associated phosphoprotein of 55 kDa SKAP1;SCAP1;SKAP55 Q86WV1-1;Q86WV1;Q86WV1-2 ENST00000336915;ENST00000393398 2 0.78741 1.534 0.80979 1.0657 0.98359 1.0791 Hist_deacetyl cell part;chromatin remodeling complex;cytoplasm;histone deacetylase complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;catalytic activity;DNA binding;histone deacetylase activity;hydrolase activity;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;nucleic acid binding;protein binding;transcription factor activity;transcription factor binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription Cell cycle;Chronic myeloid leukemia;Huntington's disease;Notch signaling pathway;Pathways in cancer 8 3 3 16.2 7.7 7.7 65.537 4.7264E-101 34822000 18737000 16085000 3671 IPI:IPI00289601.10;IPI:IPI00929375.1 Histone deacetylase 2 HDAC2 Q92769-2;Q92769;Q92769-1 ENST00000368632;ENST00000398283 K06067 2 0.48093 1.0908 0.49741 0.63994 0.68517 0.67719 PHR;RCC1 anaphase-promoting complex;cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nuclear ubiquitin ligase complex;organelle part;protein complex;ubiquitin ligase complex binding;catalytic activity;cation binding;ion binding;ligase activity;metal ion binding;transition metal ion binding;zinc ion binding metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;proteolysis;regulation of mitosis;regulation of mitotic cell cycle;regulation of transcription, DNA-dependent;transcription 18 18 18 4.8 4.8 4.8 510.39 5.5909E-171 74963000 42528000 32434000 3673 IPI:IPI00289776.3;IPI:IPI00607852.2 Probable E3 ubiquitin-protein ligase MYCBP2;Myc-binding protein 2;Protein associated with Myc;Pam/highwire/rpm-1 protein MYCBP2;KIAA0916;PAM O75592-1;O75592;O75592-2 ENST00000357337;ENST00000407578 K10693 2 0.84641 1.6784 0.80893 1.2043 1.0196 1.0354 zf-C3HC4;zf-CHY cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding 6 6 6 28.7 28.7 28.7 30.11 1.0973E-35 57027000 29235000 27791000 3674 IPI:IPI00289787.1;IPI:IPI00552384.1;IPI:IPI00552504.1 RING finger and CHY zinc finger domain-containing protein 1;Zinc finger protein 363;CH-rich-interacting match with PLAG1;Androgen receptor N-terminal-interacting protein;p53-induced RING-H2 protein;RING finger protein 199 RCHY1;ARNIP;CHIMP;PIRH2;RNF199;ZNF363 Q96PM5-1;Q96PM5;Q96PM5-2;Q96PM5-3 ENST00000324439 3 0.74828 1.3759 0.75415 0.96737 0.91292 0.98317 PolyA_pol cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle ATP binding;binding;catalytic activity;magnesium ion binding;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;RNA binding;transferase activity;tRNA adenylyltransferase activity;tRNA binding mitochondrial transport;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein targeting;protein targeting to mitochondrion;RNA processing;transport;tRNA metabolic process 10 10 10 21.4 21.4 21.4 50.143 1.5808E-54 194580000 105300000 89276000 3675 IPI:IPI00289807.3;IPI:IPI00301719.1;IPI:IPI00305221.1 tRNA-nucleotidyltransferase 1, mitochondrial;Mitochondrial tRNA nucleotidyl transferase, CCA-adding;mt tRNA adenylyltransferase;mt tRNA CCA-pyrophosphorylase;mt tRNA CCA-diphosphorylase;mt CCA-adding enzyme TRNT1;CGI-47 Q96Q11-1;Q96Q11;Q96Q11-2 ENST00000251607;ENST00000280591;ENST00000339437 K00974 3 0.42033 0.78722 NaN 0.5284 0.48945 NaN WD40 catalytic activity;endopeptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides;serine hydrolase activity;serine-type endopeptidase activity;serine-type peptidase activity biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis 2 2 2 1.9 1.9 1.9 163.81 2.3566E-18 1834500 1014800 819680 3676 IPI:IPI00328832.3;IPI:IPI00289815.2 WD repeat-containing protein 7;TGF-beta resistance-associated protein TRAG;Rabconnectin-3 beta WDR7;KIAA0541;TRAG Q9Y4E6-1;Q9Y4E6;Q9Y4E6-2 ENST00000254442;ENST00000357574 2 1.0671 1.7709 0.98796 1.3884 1.1596 1.2973 CIMR;fn2 clathrin-coated vesicle;coated vesicle;cytoplasmic membrane-bounded vesicle;endosome;Golgi-associated vesicle;integral to membrane;integral to plasma membrane;lysosomal membrane;membrane;transport vesicle;vacuolar membrane catalytic activity;insulin-like growth factor receptor activity;protein kinase activity;protein tyrosine kinase activity;receptor activity;signal transducer activity;transmembrane receptor activity;transmembrane receptor protein tyrosine kinase activity cell communication;cellular component organization;cellular process;endocytosis;membrane invagination;membrane organization;receptor-mediated endocytosis;regulation of biological process;signal transduction;transport;vesicle-mediated transport 40 40 40 19.8 19.8 19.8 274.27 0 844810000 407090000 437720000 3677 IPI:IPI00289819.4 Cation-independent mannose-6-phosphate receptor;Insulin-like growth factor 2 receptor;Insulin-like growth factor II receptor;M6P/IGF2 receptor;300 kDa mannose 6-phosphate receptor;MPR 300 IGF2R;MPRI P11717 ENST00000356956;ENST00000407414 K06564 1 0.78096 1.5548 1.0008 1.1198 1.1087 1.2882 fn3;ig;I-set;Y_phosphatase cell part;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part binding;catalytic activity;phosphoprotein phosphatase activity;protein binding;protein tyrosine phosphatase activity;receptor activity;signal transducer activity;transmembrane receptor activity;transmembrane receptor protein tyrosine phosphatase activity biological adhesion;cell adhesion;cellular process;dephosphorylation;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid dephosphorylation;protein metabolic process;protein modification process 7 7 6 4.9 4.9 4.3 217.09 3.2239E-24 29306000 15684000 13622000 3678 IPI:IPI00289831.4;IPI:IPI00332271.6;IPI:IPI00332273.2;IPI:IPI00332272.2;IPI:IPI00299590.5 Receptor-type tyrosine-protein phosphatase S;Receptor-type tyrosine-protein phosphatase sigma PTPRS Q13332-1;Q13332;Q13332-2;Q13332-4;Q13332-3;Q13332-5 ENST00000262963;ENST00000355005;ENST00000355322;ENST00000356037 5 0.83006 1.7913 0.76829 1.2296 1.113 1.1335 cell part;cytoplasm;intracellular organelle part;intracellular part;membrane;nuclear membrane;nuclear part;organelle membrane;organelle part cellular process;establishment of localization;establishment of localization in cell;exocytosis;secretion;secretion by cell;transport;vesicle-mediated transport 8 8 8 21.7 21.7 21.7 46.382 1.47E-56 111570000 58089000 53485000 3679 IPI:IPI00289862.5 Secernin-1 SCRN1;KIAA0193 Q12765 ENST00000242059;ENST00000409497 1 0.82948 1.4862 0.96416 1.0279 1.0667 1.1386 SNARE;Syntaxin cell part;cytoplasmic part;early endosome membrane;endosomal part;endosome membrane;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part binding;protein binding;SNAP receptor activity cellular process;establishment of protein localization;Golgi vesicle transport;intracellular protein transport;intracellular transport;post-Golgi vesicle-mediated transport;protein transport;transport;vesicle-mediated transport SNARE interactions in vesicular transport 3 3 3 14.6 14.6 14.6 29.815 1.2096E-30 110210000 58233000 51974000 3680 IPI:IPI00289876.6;IPI:IPI00552913.4 Syntaxin-7 STX7 O15400-1;O15400;O15400-2 ENST00000309255;ENST00000367937;ENST00000367941 K08488 2 0.9143 1.6617 1.1301 1.2054 1.1939 1.3985 FYTT 2 2 2 6.9 6.9 6.9 35.799 5.8742E-15 39987000 18108000 21878000 3681 IPI:IPI00289907.7 Forty-two-three domain-containing protein 1;Protein 40-2-3 FYTTD1 Q96QD9 ENST00000241502 1 1.1574 3.2956 1.0712 1.5019 2.1806 1.3742 PDZ extracellular region part;extracellular space binding;cytokine activity;protein binding;receptor binding behavior;chemotaxis;immune response;immune system process;locomotion;locomotory behavior;response to chemical stimulus;response to external stimulus;response to stimulus;taxis 3 3 3 3.2 3.2 3.2 141.75 1.1657E-51 22886000 12023000 10862000 3682 IPI:IPI00442038.3;IPI:IPI00853332.1;IPI:IPI00289966.4 Pro-interleukin-16;Interleukin-16;Lymphocyte chemoattractant factor IL16 Q14005-1;Q14005;Q14005-2;Q14005-3 ENST00000302987;ENST00000360547;ENST00000394652;ENST00000394653;ENST00000394656 3 1.1457 1.4521 0.82211 1.4145 1.0304 1.0548 WD40 8 8 5 12.4 12.4 8.1 84.778 9.2514E-75 51431000 26658000 24774000 3683 IPI:IPI00290071.3;IPI:IPI00854775.1;IPI:IPI00232818.10;IPI:IPI00046804.4 WD repeat-containing protein 42A WDR42A;H326 Q5TAQ9-1;Q5TAQ9;Q5TAQ9-2 ENST00000326837;ENST00000368073;ENST00000368074 K11804 4 0.65836 1.9365 0.74957 0.94055 1.1925 1.0934 DRY_EERY;Surp cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;protein binding;RNA binding biosynthetic process;metabolic process;mRNA splice site selection;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 5 5 5 5.3 5.3 5.3 104.85 2.0258E-09 27849000 14981000 12867000 3684 IPI:IPI00290094.4 Splicing factor, arginine/serine-rich 8;Suppressor of white apricot protein homolog SFRS8;SWAP Q12872 ENST00000261674 1 1.2031 2.3235 1.5035 1.6447 1.5063 1.9811 MA3 cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;protein binding;RNA binding aging;apoptosis;cell aging;cell cycle;cell death;negative regulation of biosynthetic process;negative regulation of protein kinase activity;regulation of biosynthetic process;regulation of protein amino acid phosphorylation 9 9 9 23.9 23.9 23.9 51.721 8.628E-91 57409000 29596000 27813000 3685 IPI:IPI00290110.5 Programmed cell death protein 4;Nuclear antigen H731-like;Neoplastic transformation inhibitor protein;Protein 197/15a PDCD4;H731 Q53EL6 ENST00000280154 1 0.6073 1.3718 0.65118 0.80341 0.90237 0.82329 CTP_synth_N;GATase cell part;cytoplasmic part;cytosol;intracellular part adenyl nucleotide binding;ATP binding;binding;catalytic activity;CTP synthase activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding CTP biosynthetic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;pyrimidine nucleoside metabolic process;pyrimidine nucleotide biosynthetic process;pyrimidine nucleotide metabolic process Pyrimidine metabolism 28 28 28 57 57 57 66.69 0 2501500000 1336400000 1165200000 3686 IPI:IPI00290142.5;IPI:IPI00645702.1 CTP synthase 1;UTP--ammonia ligase 1;CTP synthetase 1 CTPS P17812 ENST00000372616;ENST00000372621 K01937 2 NaN 1.5024 0.66811 NaN 0.96653 0.84273 KA1;Pkinase;UBA cell part;membrane;plasma membrane ATP binding;binding;catalytic activity;kinase activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cell communication;establishment or maintenance of cell polarity;intracellular signaling cascade;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;signal transduction 9 5 5 13.3 8 8 87.91 1.4399E-174 11835000 5957100 5877600 3687 IPI:IPI00555838.1;IPI:IPI00556187.1;IPI:IPI00556468.1;IPI:IPI00335766.6;IPI:IPI00718858.5;IPI:IPI00555696.3;IPI:IPI00556620.1;IPI:IPI00556171.1;IPI:IPI00556650.1;IPI:IPI00556593.1;IPI:IPI00290158.6;IPI:IPI00555760.1 Serine/threonine-protein kinase MARK2;MAP/microtubule affinity-regulating kinase 2;ELKL motif kinase;EMK1;PAR1 homolog MARK2;EMK1 Q7KZI7-1;Q7KZI7;Q7KZI7-8;Q7KZI7-11;Q7KZI7-6;Q7KZI7-3;Q7KZI7-12;Q7KZI7-9;Q7KZI7-4;Q7KZI7-5;Q7KZI7-2;Q7KZI7-7;Q7KZI7-10 ENST00000315032;ENST00000350490;ENST00000361128;ENST00000377809;ENST00000377810;ENST00000402010 K08798 12 0.61486 1.384 0.55316 0.83758 0.99495 0.79636 Methyltransf_4 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;methyltransferase activity;nucleic acid binding;protein binding;RNA binding;RNA methyltransferase activity;tRNA (guanine-N7-)-methyltransferase activity;tRNA binding;tRNA methyltransferase activity cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA modification;RNA processing;tRNA metabolic process;tRNA modification;tRNA processing 3 3 3 19.2 19.2 19.2 31.471 8.7957E-116 26571000 15866000 10705000 3688 IPI:IPI00290184.4 tRNA (guanine-N(7)-)-methyltransferase;tRNA(m7G46)-methyltransferase;Methyltransferase-like protein 1 METTL1;C12orf1 Q9UBP6 ENST00000324871;ENST00000408972 K03439 1 0.63632 1.3387 0.69508 0.84314 0.86859 0.92195 RNase_HII cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;endonuclease activity;endoribonuclease activity;hydrolase activity;hydrolase activity, acting on ester bonds;nuclease activity;nucleic acid binding;ribonuclease activity;ribonuclease H activity;RNA binding biosynthetic process;catabolic process;DNA metabolic process;DNA replication;macromolecule catabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA catabolic process DNA replication 12 12 12 46.5 46.5 46.5 33.395 4.1404E-124 754240000 395790000 358460000 3689 IPI:IPI00290192.1 Ribonuclease H2 subunit A;Ribonuclease HI subunit A;Ribonuclease HI large subunit;RNase H(35);Aicardi-Goutieres syndrome 4 protein RNASEH2A;RNASEHI;RNHIA O75792 ENST00000221486 K10743 1 0.79174 1.6247 0.78288 1.0033 1.0954 1.0016 RRM_1 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 16 16 16 32.3 32.3 32.3 51.556 2.4605E-93 1929000000 1021400000 907560000 3690 IPI:IPI00290204.1;IPI:IPI00219483.1;IPI:IPI00219484.1;IPI:IPI00219485.1 U1 small nuclear ribonucleoprotein 70 kDa SNRNP70;RNPU1Z;RPU1;SNRP70;U1AP1 P08621-1;P08621;P08621-2;P08621-3 ENST00000221448;ENST00000401730 K11093 4 0.45934 0.93338 NaN 0.6475 0.56945 NaN DNA_pol_E_B;Pol_alpha_B_N cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;catalytic activity;DNA binding;DNA polymerase activity;DNA-directed DNA polymerase activity;nucleic acid binding;nucleotidyltransferase activity;transferase activity;transferase activity, transferring phosphorus-containing groups biosynthetic process;cellular process;DNA metabolic process;DNA replication;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process DNA replication 2 2 2 6 6 6 65.947 1.5376E-09 2589800 1498600 1091200 3691 IPI:IPI00290272.2 DNA polymerase alpha subunit B;DNA polymerase alpha 70 kDa subunit POLA2 Q14181 ENST00000265465 K02321 1 0.60152 1.4786 0.71344 0.82812 0.93203 0.93616 RIO1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;p53 binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;protein tyrosine kinase activity;purine nucleoside binding cellular biopolymer metabolic process;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process 7 7 7 34 34 34 28.16 5.1322E-112 100570000 54882000 45684000 3692 IPI:IPI00290305.3 TP53-regulating kinase;p53-related protein kinase;Nori-2 TP53RK;C20orf64;PRPK Q96S44 ENST00000372114 K08851 1 0.64987 1.233 0.57345 0.8774 0.79912 0.77172 Fcf2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 10 10 10 17 17 17 90.669 2.9423E-68 81545000 43182000 38363000 3693 IPI:IPI00290410.3 Deoxynucleotidyltransferase terminal-interacting protein 2;Terminal deoxynucleotidyltransferase-interacting factor 2;Estrogen receptor-binding protein;LPTS-interacting protein 2 DNTTIP2;ERBP;TDIF2 Q5QJE6 ENST00000359208 1 0.66555 1.584 0.74628 0.96763 0.97841 1.0077 MMR_HSR1;YchF-GTPase_C cell part;cytoplasm;intracellular part adenyl nucleotide binding;ATP binding;binding;catalytic activity;GTP binding;guanyl nucleotide binding;hydrolase activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;ribonucleotide binding ATP catabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide catabolic process;purine nucleotide metabolic process 25 25 9 56.3 56.3 23.2 44.743 0 1209600000 656520000 553080000 3694 IPI:IPI00290416.3;IPI:IPI00216105.1 Obg-like ATPase 1;GTP-binding protein 9 OLA1;GTPBP9;PTD004;PRO2455 Q9NTK5-1;Q9NTK5;Q9NTK5-2 ENST00000284719;ENST00000344357;ENST00000392560;ENST00000409546 K06942 2 0.73064 1.1468 0.76212 0.93887 0.81336 0.9374 cell part;intracellular binding;catalytic activity;cation binding;ion binding;ligase activity;metal ion binding;protein binding;transition metal ion binding;zinc ion binding catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 3 3 3 10.8 10.8 10.8 54.519 1.8699E-39 55000000 29640000 25361000 3695 IPI:IPI00290429.7 E3 ubiquitin-protein ligase Hakai;Casitas B-lineage lymphoma-transforming sequence-like protein 1;c-Cbl-like protein 1;RING finger protein 188 CBLL1;HAKAI;RNF188 Q75N03 ENST00000222597 1 0.5101 0.92805 0.47972 0.66862 0.64596 0.64877 Kinesin chromosome, centromeric region;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;kinesin complex;macromolecular complex;membrane-bounded organelle;microtubule;microtubule associated complex;nucleus;organelle;protein complex ATP binding;binding;catalytic activity;DNA binding;hydrolase activity;microtubule motor activity;motor activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity cell cycle process;cell proliferation;cellular component organization;cellular process;cytoskeleton organization;microtubule cytoskeleton organization;microtubule-based movement;microtubule-based process;mitosis;nuclear division;organelle organization 14 14 13 23.2 23.2 21.7 81.312 8.5309E-90 542500000 308930000 233570000 3696 IPI:IPI00290435.3;IPI:IPI00216113.1 Kinesin-like protein KIF2C;Mitotic centromere-associated kinesin;Kinesin-like protein 6 KIF2C;KNSL6 Q99661-1;Q99661;Q99661-2 ENST00000372224 K10393 2 0.81855 1.6149 0.79344 1.1083 1.0207 1.0498 RRM_1 cell part;cytoplasmic part;cytosol;eukaryotic translation initiation factor 3 complex;intracellular part;macromolecular complex;protein complex binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity cellular process;translational initiation 8 8 8 25.9 25.9 25.9 35.611 1.8856E-101 784090000 415010000 369080000 3697 IPI:IPI00290460.3 Eukaryotic translation initiation factor 3 subunit G;Eukaryotic translation initiation factor 3 subunit 4;eIF-3-delta;Eukaryotic translation initiation factor 3 RNA-binding subunit;eIF3 p44;eIF3 p42 EIF3G;EIF3S4 O75821 ENST00000253108 K03248 1 0.67935 1.5744 0.81353 0.96216 0.96 1.071 eIF3_subunit cell part;cytoplasmic part;cytosol;eukaryotic translation initiation factor 3 complex;intracellular part;macromolecular complex;protein complex binding;nucleic acid binding;protein binding;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity cellular process;translational initiation 7 7 7 17.8 17.8 17.8 29.062 2.6261E-45 332470000 176760000 155710000 3698 IPI:IPI00290461.3 Eukaryotic translation initiation factor 3 subunit J;Eukaryotic translation initiation factor 3 subunit 1;eIF-3-alpha;eIF3 p35 EIF3J;EIF3S1;PRO0391 O75822 ENST00000261868 K03245 1 NaN 0.68559 0.36589 NaN 0.4511 0.48985 cell part;integrator complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;protein binding cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;snRNA metabolic process;snRNA processing 5 5 5 8.5 8.5 8.5 73.814 1.3897E-38 58863000 34351000 24512000 3700 IPI:IPI00290514.1 Integrator complex subunit 9;Protein related to CPSF subunits of 74 kDa INTS9;RC74 Q9NV88 ENST00000265614 1 0.76741 NaN NaN 1.0607 NaN NaN SH3_1;UIM;VHS cell part;cytoplasmic part;cytosol;early endosome membrane;endosomal part;endosome membrane;intracellular organelle part;intracellular part;membrane;organelle membrane;organelle part binding;protein binding establishment of localization;establishment of localization in cell;establishment of protein localization;intracellular protein transport;intracellular transport;protein transport;transport Jak-STAT signaling pathway 3 1 1 5.5 1.9 1.9 58.164 2.9506E-14 887090 448580 438510 3701 IPI:IPI00290542.1;IPI:IPI00607771.1 Signal transducing adapter molecule 2;Hrs-binding protein STAM2;HBP O75886-1;O75886;O75886-2 ENST00000263904 K04705 2 0.80622 NaN 0.89579 1.0824 NaN 1.1975 GST_C;GST_N cell part;cytoplasm;intracellular part 3 3 3 10.1 10.1 10.1 41.345 4.3193E-87 21447000 12157000 9289500 3702 IPI:IPI00877014.1;IPI:IPI00290544.3 Ganglioside-induced differentiation-associated protein 1 GDAP1 Q8TB36-1;Q8TB36;Q8TB36-2 ENST00000220822 2 0.93001 1.7922 0.96207 1.1967 1.1993 1.2324 Cpn60_TCP1 cell part;cytoplasmic part;cytosol;intracellular part adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding anatomical structure formation;cellular component assembly;cellular component organization;cellular process;metabolic process;protein complex assembly;protein folding;protein metabolic process;tubulin complex assembly 43 43 43 79.1 79.1 79.1 60.343 0 15361000000 7877100000 7483800000 3704 IPI:IPI00290566.1 T-complex protein 1 subunit alpha;CCT-alpha CCT1;CCTA;TCP1 P17987 ENST00000321394 1 0.61197 1.0625 NaN 0.75696 0.74604 NaN F-box binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 2 2 2 4 4 4 82.303 4.7482E-63 732960 375440 357510 3705 IPI:IPI00290571.3 F-box only protein 30 FBXO30;FBX30 Q8TB52 ENST00000237281 K10307 1 0.36806 0.76466 0.30007 0.46626 0.52282 0.379 Endonuclease_NS cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle binding;catalytic activity;cation binding;endonuclease activity;hydrolase activity;hydrolase activity, acting on ester bonds;ion binding;magnesium ion binding;manganese ion binding;metal ion binding;nuclease activity;nucleic acid binding Apoptosis 2 2 2 7.7 7.7 7.7 32.646 0.0036742 10390000 6464400 3925400 3706 IPI:IPI00290614.7 Endonuclease G, mitochondrial ENDOG Q14249 ENST00000372642 K01173 1 NaN 1.8644 NaN NaN 1.1045 NaN PHD cell part;chromatin remodeling complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex;RSF complex binding;cation binding;histone binding;ion binding;metal ion binding;protein binding;transcription activator activity;transcription regulator activity;transcription repressor activity;transition metal ion binding;zinc ion binding chromatin assembly or disassembly;chromatin organization;chromatin remodeling;nucleosome assembly;organelle organization;regulation of biosynthetic process;regulation of transcription, DNA-dependent;transcription initiation 3 3 3 2.9 2.9 2.9 163.82 7.1254E-101 2211500 1354300 857140 3707 IPI:IPI00290652.4;IPI:IPI00514411.2;IPI:IPI00479823.3 Remodeling and spacing factor 1;Hepatitis B virus X-associated protein;HBV pX-associated protein 8;p325 subunit of RSF chromatin-remodeling complex RSF1;HBXAP;XAP8 Q96T23-1;Q96T23;Q96T23-2;Q96T23-3 ENST00000308488;ENST00000360355 K11657 3 0.60313 1.3817 0.57712 0.7553 0.96733 0.8166 PNK3P cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part ATP binding;binding;catalytic activity;damaged DNA binding;DNA binding;double-stranded DNA binding;endonuclease activity;kinase activity;nuclease activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding DNA catabolic process;DNA metabolic process;DNA replication;DNA-dependent DNA replication;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;nucleotide-excision repair, DNA damage removal 6 6 6 10.7 10.7 10.7 57.076 2.5483E-08 13391000 7440400 5950200 3708 IPI:IPI00290684.3 Bifunctional polynucleotide phosphatase/kinase;Polynucleotide kinase-3'-phosphatase;DNA 5'-kinase/3'-phosphatase;Polynucleotide 3'-phosphatase;2'(3')-polynucleotidase;Polynucleotide 5'-hydroxyl-kinase PNKP Q96T60 ENST00000322344 K08073;K08075 1 0.41206 0.66595 0.73571 0.51071 0.47015 0.95595 Helicase_C;SNF2_N;zf-GRF cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;ribonucleoprotein complex;spliceosomal complex;transcription elongation factor complex ATP binding;binding;catalytic activity;DNA binding;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;RNA polymerase II transcription termination factor activity;transcription termination factor activity metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;RNA processing;RNA splicing;transcription termination 6 6 6 5.1 5.1 5.1 129.59 1.622E-29 49771000 26836000 22934000 3710 IPI:IPI00290812.2;IPI:IPI00640904.1 Transcription termination factor 2;RNA polymerase II termination factor;Transcription release factor 2;HuF2;Lodestar homolog TTF2 Q9UNY4-1;Q9UNY4 ENST00000369466 2 NaN 1.8913 0.88939 NaN 1.1828 1.2256 Mito_carr cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part binding establishment of localization;transport 4 4 4 13.6 13.6 13.6 38.124 1.7095E-31 14323000 4864800 9458100 3711 IPI:IPI00290827.3 Solute carrier family 25 member 40;Mitochondrial carrier family protein SLC25A40;MCFP Q8TBP6 ENST00000341119 1 0.68449 1.3292 0.53073 0.86569 0.88708 0.66712 G-alpha cytoplasmic membrane-bounded vesicle;cytoplasmic part;cytoplasmic vesicle;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;melanosome;membrane;membrane-bounded organelle;membrane-bounded vesicle;organelle;vesicle binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity;signal transducer activity biological regulation;cell communication;cell motion;cell surface receptor linked signal transduction;cellular process;G-protein coupled receptor protein signaling pathway;regulation of biological process;regulation of cellular process;signal transduction Long-term depression;Regulation of actin cytoskeleton;Vascular smooth muscle contraction 8 8 8 23.9 23.9 23.9 44.049 1.2708E-30 76271000 42445000 33826000 3712 IPI:IPI00290928.2 Guanine nucleotide-binding protein subunit alpha-13 GNA13 Q14344 ENST00000239138 K04639 1 0.59174 1.3694 0.66355 0.81001 0.89094 0.89161 Nop52 cytosol;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nucleolus;organelle;organelle part;preribosome;preribosome, small subunit precursor;ribonucleoprotein complex binding;protein binding cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 20 20 20 32.7 32.7 32.7 84.41 0 597810000 316420000 281390000 3713 IPI:IPI00290952.6;IPI:IPI00032374.3 Ribosomal RNA processing protein 1 homolog B;RRP1-like protein B RRP1B;KIAA0179 Q14684-1;Q14684;Q14684-2 ENST00000340648 2 0.58328 1.3752 0.60208 0.8125 0.83461 0.84747 Mov34 binding;catalytic activity;cation binding;hydrolase activity;hydrolase activity, acting on ester bonds;ion binding;metallopeptidase activity;peptidase activity;thiolester hydrolase activity;ubiquitin thiolesterase activity;zinc ion binding catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 5 5 5 12.4 12.4 12.4 49.783 1.094E-56 47572000 27336000 20236000 3714 IPI:IPI00290975.5;IPI:IPI00002208.2 AMSH-like protease;STAM-binding protein-like 1 STAMBPL1;AMSHLP;KIAA1373 Q96FJ0-1;Q96FJ0;Q96FJ0-2 ENST00000371924;ENST00000371926;ENST00000371927 K11867 2 0.86536 1.6092 0.86756 1.122 1.0609 1.1015 Ldh_1_C;Ldh_1_N cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part binding;catalytic activity;L-malate dehydrogenase activity;malate dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor acetyl-CoA metabolic process;alcohol metabolic process;carbohydrate metabolic process;generation of precursor metabolites and energy;glucose catabolic process;glucose metabolic process;monosaccharide metabolic process;organic acid metabolic process Carbon fixation in photosynthetic organisms;Citrate cycle (TCA cycle);Glyoxylate and dicarboxylate metabolism;Pyruvate metabolism;Reductive carboxylate cycle (CO2 fixation) 20 20 20 63.3 63.3 63.3 35.503 0 8102300000 4259900000 3842500000 3716 IPI:IPI00291006.2 Malate dehydrogenase, mitochondrial MDH2 P40926 ENST00000315758 K00026 1 0.67644 1.1776 0.67866 0.8721 0.8297 0.87807 zf-AN1 binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding 2 2 2 9 9 9 30.787 7.585E-15 37502000 19663000 17839000 3717 IPI:IPI00291064.4;IPI:IPI00642318.1 AN1-type zinc finger protein 1 ZFAND1 Q8TCF1-1;Q8TCF1;Q8TCF1-2 ENST00000220669 K07059 2 0.32808 NaN NaN 0.47089 NaN NaN PI3_PI4_kinase cell part;cytoplasm;intracellular part;membrane 1-phosphatidylinositol 4-kinase activity;ATP binding;binding;catalytic activity;inositol or phosphatidylinositol kinase activity;kinase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;transferase activity 2 2 2 5 5 5 54.744 2.7547E-11 1463100 963390 499750 3718 IPI:IPI00291068.3 Phosphatidylinositol 4-kinase type 2-beta;Phosphatidylinositol 4-kinase type II-beta PI4K2B Q8TCG2 ENST00000264864 1 0.6211 1.1353 0.6151 0.84008 0.74957 0.78095 RNA_pol_Rpb5_C;RNA_pol_Rpb5_N cell part;DNA-directed RNA polymerase complex;DNA-directed RNA polymerase II, core complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;RNA polymerase complex binding;catalytic activity;DNA binding;DNA-directed RNA polymerase activity;nucleic acid binding;nucleotidyltransferase activity;protein binding;RNA polymerase activity;transferase activity;transferase activity, transferring phosphorus-containing groups nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile Huntington's disease;RNA polymerase 3 3 3 15.2 15.2 15.2 24.551 4.7604E-54 211030000 116110000 94920000 3719 IPI:IPI00291093.3 DNA-directed RNA polymerases I, II, and III subunit RPABC1;DNA-directed RNA polymerase II subunit E;RPB5;DNA-directed RNA polymerase II 23 kDa polypeptide;XAP4 POLR2E P19388 ENST00000215587 K03013 1 0.67085 1.3962 0.74496 0.89118 0.90933 0.98621 THOC7 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 4 4 4 24 24 24 23.743 5.9869E-108 90463000 49332000 41132000 3720 IPI:IPI00291131.6 THO complex subunit 7 homolog;Ngg1-interacting factor 3-like protein 1-binding protein 1 THOC7;NIF3L1BP1 Q6I9Y2 ENST00000295899 1 0.75871 1.7218 0.74992 0.9872 1.1495 0.99898 Vinculin actin cytoskeleton;adherens junction;cell junction;cell-cell junction;cell-substrate adherens junction;cell-substrate junction;costamere;cytoskeleton;focal adhesion;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;organelle actin binding;alpha-catenin binding;binding;catalytic activity;cytoskeletal protein binding;oxidoreductase activity;protein binding;structural molecule activity anatomical structure formation;biological adhesion;cell adhesion;cell motion;cell projection assembly;cell projection organization;cell-cell junction assembly;cellular component assembly;cellular component organization;cellular process Adherens junction;Focal adhesion;Leukocyte transendothelial migration;Regulation of actin cytoskeleton 23 23 23 24.6 24.6 24.6 123.8 1.1925E-243 333380000 183130000 150250000 3721 IPI:IPI00307162.2;IPI:IPI00291175.7;IPI:IPI00384973.1 Vinculin;Metavinculin VCL P18206-1;P18206;P18206-2 ENST00000211998;ENST00000372755 K05700 3 0.66624 1.2864 0.66716 0.86778 0.87784 0.86332 Nup133;Nup133_N condensed chromosome kinetochore;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;kinetochore;macromolecular complex;membrane part;non-membrane-bounded organelle;nuclear pore;organelle;organelle part;protein complex binding;nucleocytoplasmic transporter activity;protein binding;transporter activity cellular process;establishment of protein localization;intracellular protein transport;mRNA export from nucleus;nucleobase, nucleoside, nucleotide and nucleic acid transport;nucleocytoplasmic transport;protein transport;RNA export from nucleus;transport 14 14 14 15.8 15.8 15.8 128.98 1.1601E-166 176810000 99740000 77074000 3722 IPI:IPI00291200.2 Nuclear pore complex protein Nup133;Nucleoporin Nup133;133 kDa nucleoporin NUP133 Q8WUM0 ENST00000261396 1 NaN 12.792 NaN NaN 7.6209 NaN Clusterin extracellular region part;high-density lipoprotein particle;macromolecular complex;plasma lipoprotein particle;protein-lipid complex;spherical high-density lipoprotein particle binding;protein binding activation of immune response;activation of plasma proteins involved in acute inflammatory response;immune effector process;immune system process;lipid metabolic process;positive regulation of immune system process;regulation of immune system process 5 5 5 12.4 12.4 12.4 57.832 3.8916E-11 2945300 2781800 163430 3723 IPI:IPI00400826.1;IPI:IPI00291262.3 Clusterin;Complement-associated protein SP-40,40;Complement cytolysis inhibitor;NA1/NA2;Apolipoprotein J;Testosterone-repressed prostate message 2;Ku70-binding protein 1;Aging-associated gene 4 protein;Clusterin beta chain;ApoJalpha;Complement cytolysis inhibitor a chain;Clusterin alpha chain;ApoJbeta;Complement cytolysis inhibitor b chain CLU;APOJ;CLI;KUB1;AAG4 P10909-2;P10909;P10909-1 ENST00000380446;ENST00000405140 2 0.63476 1.0123 0.64918 0.80376 0.69792 0.81281 NUDIX cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle binding;catalytic activity;cation binding;hydrolase activity;ion binding;magnesium ion binding;manganese ion binding;metal ion binding;transition metal ion binding Folate biosynthesis 3 3 3 20.3 20.3 20.3 25.37 4.783E-10 86278000 44968000 41310000 3724 IPI:IPI00291313.2;IPI:IPI00607555.1 Nucleoside diphosphate-linked moiety X motif 8, mitochondrial NUDT8 Q8WV74-1;Q8WV74;Q8WV74-2 ENST00000301490;ENST00000376693 K01529 2 0.74197 1.2366 0.80244 0.97356 0.86839 1.0058 C1_1;PH;RhoGEF cell junction;cell-cell junction;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;microtubule;non-membrane-bounded organelle;organelle;spindle;tight junction binding;cytoskeletal protein binding;guanyl-nucleotide exchange factor activity;microtubule binding;protein binding;Ras guanyl-nucleotide exchange factor activity;Rho guanyl-nucleotide exchange factor activity;small GTPase regulator activity actin filament organization;cell communication;cell morphogenesis;cytoskeleton organization;mitosis;negative regulation of microtubule depolymerization;nuclear division;organelle organization;signal transduction 24 24 24 26.9 26.9 26.9 121.08 2.9999E-225 836620000 424180000 412440000 3726 IPI:IPI00472160.5;IPI:IPI00291316.5;IPI:IPI00940816.1 Rho guanine nucleotide exchange factor 2;Guanine nucleotide exchange factor H1;Microtubule-regulated Rho-GEF;Proliferating cell nucleolar antigen p40 ARHGEF2;KIAA0651;LFP40 Q92974-2;Q92974;Q92974-1;Q92974-3 ENST00000361247;ENST00000368315 3 0.87081 1.5598 0.7674 1.1182 1.0558 1.0026 Complex1_24kDa cytoplasmic part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;mitochondrial membrane part;mitochondrial part;mitochondrial respiratory chain complex I;NADH dehydrogenase complex;organelle part;protein complex binding;catalytic activity;electron carrier activity;iron ion binding;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH cellular process;electron transport chain;generation of precursor metabolites and energy;metabolic process;mitochondrial electron transport, NADH to ubiquinone;nervous system development;striated muscle tissue development;tissue development;transport Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 3 3 3 14.5 14.5 14.5 27.391 8.5542E-45 146470000 80573000 65893000 3727 IPI:IPI00291328.3 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial;NADH-ubiquinone oxidoreductase 24 kDa subunit NDUFV2 P19404 ENST00000318388;ENST00000400033 K03943 1 0.53277 1.3571 0.37126 0.74323 0.79044 0.54618 Methyltransf_15 Cajal body;cell part;cytoplasm;intracellular organelle part;intracellular part;nuclear body;nuclear part;nucleoplasm part;organelle part catalytic activity;methyltransferase activity;transferase activity;transferase activity, transferring one-carbon groups nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;one-carbon metabolic process;regulation of transcription, DNA-dependent;RNA methylation;RNA processing;spliceosomal snRNP biogenesis;transcription 5 5 5 6.6 6.6 6.6 96.607 1.3237E-16 23275000 12277000 10997000 3728 IPI:IPI00291376.4 Trimethylguanosine synthase homolog;Nuclear receptor coactivator 6-interacting protein;PRIP-interacting protein with methyltransferase motif;CLL-associated antigen KW-2;Hepatocellular carcinoma-associated antigen 137 TGS1;HCA137;NCOA6IP;PIMT Q96RS0 ENST00000260129 1 0.8456 1.5104 0.83705 1.0973 0.9605 1.1026 RRM_1 binding;mRNA binding;nucleic acid binding;nucleotide binding;poly(A) RNA binding;poly-purine tract binding;protein binding;RNA binding;single-stranded RNA binding apoptosis;cell death;cellular process;death;induction of apoptosis;induction of programmed cell death;positive regulation of apoptosis;positive regulation of cell death;programmed cell death;regulation of apoptosis;regulation of cell death 9 9 1 33.4 33.4 5.7 42.963 4.2198E-145 568360000 293510000 274850000 3729 IPI:IPI00291398.2 Nucleolysin TIA-1 isoform p40;p40-TIA-1;RNA-binding protein TIA-1;Nucleolysin TIA-1 isoform p15;p15-TIA-1 TIA1 P31483-1;P31483 ENST00000282574;ENST00000361692 1 0.74854 1.2673 0.80819 0.9525 0.89064 1.0031 PP2C cell part;macromolecular complex;protein complex;protein serine/threonine phosphatase complex binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;magnesium ion binding;manganese ion binding;phosphatase activity;phosphoprotein phosphatase activity;protein serine/threonine phosphatase activity apoptosis;cell death;cellular process;death;dephosphorylation;metabolic process;phosphate metabolic process;phosphorus metabolic process;programmed cell death;protein amino acid dephosphorylation;protein metabolic process;protein modification process 6 6 6 23.3 23.3 23.3 49.83 4.2065E-89 199070000 106390000 92675000 3731 IPI:IPI00291412.1 Protein phosphatase 1F;Ca(2+)/calmodulin-dependent protein kinase phosphatase;Partner of PIX 2 PPM1F;KIAA0015;POPX2 P49593 ENST00000263212;ENST00000406981 K01090 1 0.58167 1.362 0.58634 0.78957 0.93833 0.76139 CoaE adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding 10 10 10 46.3 46.3 46.3 26.55 2.1876E-87 46957000 26937000 20021000 3732 IPI:IPI00291417.2;IPI:IPI00015737.1 Dephospho-CoA kinase domain-containing protein DCAKD Q8WVC6-1;Q8WVC6 ENST00000310604;ENST00000342350 2 0.80387 1.3245 0.85103 1.0012 0.94695 1.056 Thiolase_C;Thiolase_N cell part;cytoplasm;intracellular part acetyl-CoA C-acetyltransferase activity;acetyltransferase activity;acyltransferase activity;binding;C-acetyltransferase activity;C-acyltransferase activity;catalytic activity;protein binding;transferase activity lipid metabolic process;metabolic process;primary metabolic process Benzoate degradation via CoA ligation;Butanoate metabolism;Fatty acid metabolism;Lysine degradation;Propanoate metabolism;Pyruvate metabolism;Synthesis and degradation of ketone bodies;Tryptophan metabolism;Two-component system;Valine, leucine and isoleucine degradation 13 13 13 46.9 46.9 46.9 44.642 0 721890000 365380000 356510000 3733 IPI:IPI00291419.6 Acetyl-CoA acetyltransferase, cytosolic;Cytosolic acetoacetyl-CoA thiolase;Acetyl-CoA transferase-like protein ACAT2;ACTL Q9BWD1 ENST00000367048 K00626 1 0.71432 1.6023 0.70049 0.9756 1.0421 0.94001 Mito_carr cytoplasmic part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;macromolecular complex;membrane part;mitochondrial inner membrane presequence translocase complex;mitochondrial part;organelle part;protein complex active transmembrane transporter activity;antiporter activity;ATP:ADP antiporter activity;binding;protein binding;secondary active transmembrane transporter activity;solute:solute antiporter activity;transmembrane transporter activity;transporter activity apoptosis;cell death;cellular process;death;establishment of localization;interspecies interaction between organisms;multi-organism process;programmed cell death;transport Calcium signaling pathway;Huntington's disease;Parkinson's disease 21 8 4 46.3 19.1 10.1 32.866 0 431330000 241290000 190050000 3734 IPI:IPI00291467.7 ADP/ATP translocase 3;Adenine nucleotide translocator 2;ANT 3;ADP,ATP carrier protein 3;Solute carrier family 25 member 6;ADP,ATP carrier protein, isoform T2 SLC25A6;ANT3;CDABP0051 P12236 ENST00000381401 K05863 1 0.64185 1.2914 0.66373 0.91741 0.83388 0.89819 CBS;IMPDH cell part;cytoplasmic part;cytosol;intracellular part binding;catalytic activity;IMP dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;protein binding GMP biosynthetic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process Drug metabolism - other enzymes;Purine metabolism 47 47 45 62.6 62.6 60.7 55.804 0 9733500000 5155400000 4578100000 3735 IPI:IPI00291510.3 Inosine-5'-monophosphate dehydrogenase 2;IMPDH-II;IMPD 2 IMPDH2;IMPD2 P12268 ENST00000326739 K00088 1 0.5461 1.1577 0.47668 0.7225 0.69984 0.62101 RrnaAD cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial nucleoid;mitochondrial part;nucleoid;organelle part binding;catalytic activity;DNA binding;methyltransferase activity;N-methyltransferase activity;nucleic acid binding;RNA methyltransferase activity;rRNA (adenine-N6,N6-)-dimethyltransferase activity;rRNA methyltransferase activity biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;RNA processing;rRNA modification;rRNA processing;transcription 7 7 7 19.4 19.4 19.4 39.542 5.5362E-32 111770000 59229000 52538000 3736 IPI:IPI00291525.1 Dimethyladenosine transferase 1, mitochondrial;S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1;Mitochondrial 12S rRNA dimethylase 1;Mitochondrial transcription factor B1 TFB1M;CGI-75 Q8WVM0 ENST00000367166 1 0.40757 0.91736 NaN 0.51287 0.57813 NaN DAO;SE cell fraction;endoplasmic reticulum membrane;insoluble fraction;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane fraction;membrane part;microsome;organelle membrane;organelle part;vesicular fraction binding;catalytic activity;monooxygenase activity;nucleoside binding;nucleotide binding;oxidoreductase activity;purine nucleoside binding;squalene monooxygenase activity alcohol metabolic process;biosynthetic process;cellular process;lipid biosynthetic process;lipid metabolic process;metabolic process;steroid biosynthetic process;steroid metabolic process;sterol biosynthetic process;sterol metabolic process 2 2 2 4.7 4.7 4.7 63.938 6.5613E-05 680280 493200 187080 3737 IPI:IPI00291544.3 Squalene monooxygenase;Squalene epoxidase SQLE;ERG1 Q14534 ENST00000265896 1 NaN 4.1074 NaN NaN 2.8509 NaN Arginase cell part;cytoplasm;intracellular part arginase activity;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines;manganese ion binding arginine catabolic process;arginine metabolic process;cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;metabolic process;nitrogen compound metabolic process;organic acid metabolic process;urea cycle Arginine and proline metabolism 7 7 7 24.8 24.8 24.8 35.664 1.1988E-65 10122000 8787500 1335000 3738 IPI:IPI00398768.1;IPI:IPI00291560.4;IPI:IPI00038356.4 Arginase-1;Type I arginase;Liver-type arginase ARG1 P05089-2;P05089;P05089-1;P05089-3 ENST00000275196;ENST00000356962;ENST00000368087 K01476 3 0.45008 0.92899 0.45264 0.59588 0.61954 0.63024 CARD;Peptidase_C14 cell part;intracellular binding;catalytic activity;cysteine-type endopeptidase activity;cysteine-type peptidase activity;endopeptidase activity;enzyme binding;hydrolase activity;identical protein binding;peptidase activity;protein binding;protein domain specific binding apoptosis;catabolic process;cell death;cellular process;death;macromolecule catabolic process;metabolic process;programmed cell death;protein catabolic process;protein metabolic process;protein processing;proteolysis;regulation of cell death 14 14 14 39.6 39.6 39.6 50.685 3.9317E-280 247510000 141590000 105930000 3739 IPI:IPI00291570.9;IPI:IPI00216410.1 Caspase-2;ICH-1 protease;Neural precursor cell expressed developmentally down-regulated protein 2;Caspase-2 subunit p18;Caspase-2 subunit p13;Caspase-2 subunit p12 CASP2;ICH1;NEDD2 P42575-1;P42575;P42575-2 ENST00000310447;ENST00000392923 K02186 2 0.75602 1.5196 0.71615 0.95669 0.98758 0.92682 Pribosyltran binding;catalytic activity;diphosphotransferase activity;enzyme inhibitor activity;magnesium ion binding;protein binding;ribose phosphate diphosphokinase activity;transferase activity;transferase activity, transferring phosphorus-containing groups biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside metabolic process;nucleoside phosphate metabolic process;nucleotide metabolic process 10 10 9 41 41 37.1 39.393 1.4788E-201 197360000 104390000 92970000 3740 IPI:IPI00291578.7 Phosphoribosyl pyrophosphate synthetase-associated protein 1;39 kDa phosphoribosypyrophosphate synthetase-associated protein PRPSAP1 Q14558 ENST00000324684 1 0.92992 2.2555 1.037 1.2566 1.4495 1.4008 Kinesin intracellular non-membrane-bounded organelle;intracellular organelle;kinesin complex;macromolecular complex;microtubule;microtubule associated complex;non-membrane-bounded organelle;nucleoplasm;organelle;organelle part;protein complex;spindle ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;microtubule motor activity;motor activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity cell cycle phase;cell cycle process;cellular component organization;cellular process;microtubule-based movement;microtubule-based process;mitosis;mitotic spindle elongation;nuclear division;organelle fission;organelle organization;spindle elongation 12 12 12 14.8 14.8 14.8 110.06 5.6946E-94 76943000 41720000 35223000 3741 IPI:IPI00291579.7;IPI:IPI00293884.6 Kinesin-like protein KIF23;Mitotic kinesin-like protein 1;Kinesin-like protein 5 KIF23;KNSL5;MKLP1 Q02241-1;Q02241;Q02241-2 ENST00000260363;ENST00000352331 K10402 2 0.73234 1.6333 0.76442 0.99374 1.0401 1.0191 Ins145_P3_rec;Ion_trans;MIR;RIH_assoc;RYDR_ITPR brush border;endoplasmic reticulum membrane;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane;nuclear membrane;nuclear outer membrane;organelle membrane;organelle outer membrane;outer membrane inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity;inositol hexakisphosphate binding;intracellular ligand-gated ion channel activity;ion channel activity;receptor activity;signal transducer activity;transporter activity calcium ion transport;cation transport;cell communication;cellular calcium ion homeostasis;cellular ion homeostasis;cellular metal ion homeostasis;ion transport;protein complex assembly;signal transduction;transport Alzheimer's disease;Calcium signaling pathway;Gap junction;GnRH signaling pathway;Long-term depression;Long-term potentiation;Phosphatidylinositol signaling system;Taste transduction;Vascular smooth muscle contraction 4 3 3 1.4 1 1 304.1 5.4713E-07 27952000 15176000 12776000 3742 IPI:IPI00291607.2 Inositol 1,4,5-trisphosphate receptor type 3;Type 3 inositol 1,4,5-trisphosphate receptor;Type 3 InsP3 receptor;IP3 receptor isoform 3;InsP3R3 ITPR3 Q14573 ENST00000374316 K04960 1 0.68544 1.5839 0.75187 1.027 0.92375 1.0251 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding catabolic process;cell cycle;cellular process;macromolecule catabolic process;metabolic process;proteasomal protein catabolic process;protein modification process;protein ubiquitination;proteolysis;ubiquitin-dependent protein catabolic process 8 8 8 39.9 39.9 39.9 18.925 1.2287E-112 482160000 257820000 224340000 3743 IPI:IPI00291608.4;IPI:IPI00060650.3;IPI:IPI00604582.1 PEST proteolytic signal-containing nuclear protein PCNP Q8WW12-1;Q8WW12;Q8WW12-2 ENST00000265260;ENST00000296024 3 0.95802 0.63545 NaN 1.1798 0.45065 NaN SPRY 4 4 4 17.4 17.4 17.4 23.098 1.1522E-08 20092000 8986300 11106000 3744 IPI:IPI00291643.3 SPRY domain-containing protein 4 SPRYD4 Q8WW59 ENST00000338146 1 0.82721 1.5036 0.81854 1.1062 0.99096 1.1027 NIF;ubiquitin cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;phosphatase activity;phosphoprotein phosphatase activity;phosphoric ester hydrolase activity 10 10 10 32.1 32.1 32.1 36.804 5.6974E-32 108100000 54801000 53302000 3745 IPI:IPI00291669.3 Ubiquitin-like domain-containing CTD phosphatase 1 UBLCP1 Q8WVY7 ENST00000296786 K01090 1 0.73437 1.6356 1.0195 0.97112 1.0779 1.4008 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle 5 5 5 18.6 18.6 18.6 32.544 8.2939E-35 69333000 35530000 33803000 3747 IPI:IPI00291751.6 Uncharacterized protein C2orf47, mitochondrial C2orf47 Q8WWC4 ENST00000295079;ENST00000392290 1 0.72868 1.3749 0.71625 0.93235 0.92202 0.9316 Big_2 cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;intracellular part;macromolecular complex;membrane;membrane part;nuclear membrane;nuclear part;nuclear pore;organelle membrane;organelle part;protein complex binding;protein binding cellular process;establishment of protein localization;intracellular protein transport;intracellular transport;mRNA transport;nucleic acid transport;nucleobase, nucleoside, nucleotide and nucleic acid transport;protein transport;RNA transport;transport 35 35 35 25.3 25.3 25.3 205.11 0 1389300000 753530000 635810000 3748 IPI:IPI00291755.6;IPI:IPI00871723.1 Nuclear pore membrane glycoprotein 210 NUP210;KIAA0906;PSEC0245 Q8TEM1-1;Q8TEM1 ENST00000254508 2 0.50644 0.95178 0.50555 0.64301 0.6571 0.65421 WD40 Cajal body;cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;nuclear body;nuclear part;nucleoplasm part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;protein binding;RNA binding;snRNA binding anatomical structure formation;cellular component assembly;cellular component organization;cellular process;macromolecular complex subunit organization;protein complex assembly;ribonucleoprotein complex biogenesis;spliceosomal snRNP biogenesis 18 18 18 13.7 13.7 13.7 168.56 1.3393E-104 246420000 135050000 111360000 3749 IPI:IPI00291783.3 Gem-associated protein 5 GEMIN5 Q8TEQ6 ENST00000285873 1 0.7228 1.3315 0.74551 0.97345 0.89922 0.9849 EGF_2;Integrin_b_cyt;Integrin_B_tail;Integrin_beta cell part;cytoplasm;integrin complex;intracellular part;macromolecular complex;membrane part;plasma membrane part;protein complex;receptor complex binding;enzyme binding;glycoprotein binding;kinase binding;molecular transducer activity;protein binding;protein kinase binding;receptor activity;signal transducer activity apoptosis;cell adhesion;cell communication;cell motion;cell-matrix adhesion;chemotaxis;defense response;immune system process;inflammatory response;leukocyte adhesion;regulation of protein amino acid phosphorylation;response to stress;signal transduction Cell adhesion molecules (CAMs);Leukocyte transendothelial migration;Natural killer cell mediated cytotoxicity;Regulation of actin cytoskeleton 22 22 22 30.2 30.2 30.2 84.781 5.148E-177 930440000 488950000 441490000 3750 IPI:IPI00291792.2;IPI:IPI00297880.3;IPI:IPI00412656.2 Integrin beta-2;Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta;Complement receptor C3 subunit beta ITGB2;CD18;MFI7 P05107 ENST00000302347;ENST00000355153;ENST00000397850;ENST00000397852;ENST00000397857 K06464 3 1.4467 1.571 1.3829 1.7864 1.1214 1.6982 EIF4E-T cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding;protein transporter activity;substrate-specific transporter activity;transporter activity establishment of localization;establishment of protein localization;protein transport;transport 2 2 2 2.9 2.9 2.9 108.2 0.0027896 12065000 4827100 7237900 3751 IPI:IPI00291800.1;IPI:IPI00550518.1 Eukaryotic translation initiation factor 4E transporter;Eukaryotic translation initiation factor 4E nuclear import factor 1 EIF4ENIF1 Q9NRA8-1;Q9NRA8;Q9NRA8-2 ENST00000330125;ENST00000344710;ENST00000397525 2 1.011 2.1767 NaN 1.3407 1.4431 NaN cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 3 3 3 2.4 2.4 2.4 155.14 4.62E-11 2130900 1261400 869520 3753 IPI:IPI00377187.6;IPI:IPI00657833.1;IPI:IPI00847998.1;IPI:IPI00291825.4;IPI:IPI00477282.4;IPI:IPI00847363.1;IPI:IPI00847273.1 AT-hook-containing transcription factor AKNA;KIAA1968 Q7Z591-1;Q7Z591;Q7Z591-2;Q7Z591-7;Q7Z591-8;Q7Z591-3 ENST00000307564;ENST00000374079;ENST00000374088;ENST00000394574;ENST00000394582 7 0.75664 1.6279 0.76179 1.0491 1.0359 0.95951 DUF298 catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 4 4 4 18.1 18.1 18.1 30.124 2.0168E-26 71602000 39776000 31826000 3755 IPI:IPI00291893.4 DCN1-like protein 1;Defective in cullin neddylation protein 1-like protein 1;DCUN1 domain-containing protein 1;Squamous cell carcinoma-related oncogene DCUN1D1;DCUN1L1;RP42;SCCRO Q96GG9 ENST00000292782 1 0.73239 1.1209 0.78405 0.93714 0.8034 0.96343 IRF;IRF-3 cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;DNA binding;nucleic acid binding;protein binding;RNA polymerase II transcription factor activity;transcription cofactor activity;transcription factor activity;transcription factor binding;transcription regulator activity nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent Toll-like receptor signaling pathway 3 3 3 7 7 7 47.219 8.3733E-13 17901000 9286500 8614400 3756 IPI:IPI00291901.1 Interferon regulatory factor 3 IRF3 Q14653 ENST00000309877;ENST00000377135 K05411 1 0.49059 0.90257 0.43947 0.64899 0.62313 0.55563 Bromodomain;WD40 binding;insulin receptor binding;protein binding;protein complex binding;receptor binding cell communication;cell surface receptor linked signal transduction;enzyme linked receptor protein signaling pathway;insulin receptor signaling pathway;signal transduction;transmembrane receptor protein tyrosine kinase signaling pathway 14 14 14 11.2 11.2 11.2 206.64 1.8378E-122 73233000 41351000 31882000 3757 IPI:IPI00291916.5;IPI:IPI00289944.5;IPI:IPI00250716.1;IPI:IPI00746752.1 PH-interacting protein;IRS-1 PH domain-binding protein;WD repeat-containing protein 11 PHIP;WDR11 Q8WWQ0 ENST00000275034 K11797 4 0.83721 1.6031 0.84696 1.093 1.0787 1.0778 Proteasome;Proteasome_A_N cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;proteasome core complex;protein complex binding;catalytic activity;endopeptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides;protein binding;threonine-type endopeptidase activity;threonine-type peptidase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Proteasome 14 14 14 71.4 71.4 71.4 26.411 0 4268300000 2207700000 2060600000 3758 IPI:IPI00291922.2 Proteasome subunit alpha type-5;Proteasome zeta chain;Macropain zeta chain;Multicatalytic endopeptidase complex zeta chain PSMA5 P28066 ENST00000271308 K02729 1 0.96067 1.9295 1.0019 1.2808 1.2465 1.2823 Ras cell fraction;cytosol;early endosome;endoplasmic reticulum;endosome;Golgi stack;Golgi-associated vesicle;insoluble fraction;late endosome;lysosome;lytic vacuole;membrane;membrane fraction;plasma membrane;rough endoplasmic reticulum;vacuole binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity cell communication;generation of a signal involved in cell-cell signaling;Golgi to endosome transport;neurotransmitter transport;post-Golgi vesicle-mediated transport;regulation of neurotransmitter levels;signal transduction;transport 19 19 17 84.7 84.7 78.6 23.897 0 1682600000 842900000 839670000 3759 IPI:IPI00291928.8 Ras-related protein Rab-14 RAB14 P61106 ENST00000373840 K07881 1 0.77672 1.3628 0.77061 1.0763 0.86285 1.0171 ENTH clathrin-coated vesicle;coated vesicle;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;membrane;membrane-bounded organelle;membrane-bounded vesicle;organelle;vesicle binding;lipid binding;protein binding cellular component organization;cellular process;endocytosis;establishment of localization;membrane invagination;membrane organization;transport;vesicle-mediated transport 14 14 14 26.1 26.1 26.1 70.294 8.9287E-124 554590000 293850000 260740000 3760 IPI:IPI00291930.6;IPI:IPI00397519.3 Clathrin interactor 1;Epsin-4;Epsin-related protein;Enthoprotin;Clathrin-interacting protein localized in the trans-Golgi region CLINT1;ENTH;EPN4;EPNR;KIAA0171 Q14677-1;Q14677;Q14677-2 ENST00000296951 2 0.71595 1.6212 0.6891 0.97045 1.0545 0.90813 SMC_hinge;SMC_N chromosome;cohesin core heterodimer;condensed chromosome;condensed chromosome kinetochore;condensed nuclear chromosome;cytoplasm;intracellular organelle;kinetochore;macromolecular complex;non-membrane-bounded organelle;nuclear chromosome;organelle ATP binding;binding;catalytic activity;chromatin binding;hydrolase activity;microtubule motor activity;motor activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity cell cycle checkpoint;microtubule cytoskeleton organization;nuclear mRNA splicing, via spliceosome;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile Cell cycle;Cell cycle - yeast 31 31 31 27.2 27.2 27.2 143.23 9.9549E-302 947450000 524260000 423190000 3761 IPI:IPI00291939.1 Structural maintenance of chromosomes protein 1A;SMC1alpha protein;Sb1.8 SMC1A;DXS423E;KIAA0178;SB1.8;SMC1;SMC1L1 Q14683 ENST00000322213 K06636 1 0.93121 1.2002 0.66757 1.2333 0.86362 0.88415 PAM2;UCH catalytic activity;cysteine-type peptidase activity;hydrolase activity;hydrolase activity, acting on ester bonds;peptidase activity;peptidase activity, acting on L-amino acid peptides;thiolester hydrolase activity;ubiquitin thiolesterase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process 10 10 10 18.3 18.3 18.3 87.69 3.1027E-79 216980000 114450000 102540000 3762 IPI:IPI00291946.9 Ubiquitin carboxyl-terminal hydrolase 10;Ubiquitin thioesterase 10;Ubiquitin-specific-processing protease 10;Deubiquitinating enzyme 10 USP10;KIAA0190 Q14694 ENST00000219473 K11841 1 0.64395 1.691 0.51828 0.92837 1.1341 0.70526 ADH_N;ADH_zinc_N cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle binding;catalytic activity;cation binding;ion binding;metal ion binding;oxidoreductase activity;transition metal ion binding;zinc ion binding metabolic process;oxidation reduction 4 4 4 14.4 14.4 14.4 43.589 4.8437E-15 15758000 8655700 7101800 3763 IPI:IPI00291972.2;IPI:IPI00651757.1;IPI:IPI00383312.2 Reticulon-4-interacting protein 1;NOGO-interacting mitochondrial protein RTN4IP1;NIMP Q8WWV3-1;Q8WWV3;Q8WWV3-3;Q8WWV3-2 ENST00000369063 3 0.70413 1.4004 0.74636 0.95465 0.89614 1.0049 PHD cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transition metal ion binding;zinc ion binding 6 6 6 14.2 14.2 14.2 67.089 5.032E-23 27806000 14912000 12893000 3764 IPI:IPI00291983.7;IPI:IPI00216510.5 Metal-response element-binding transcription factor 2;Metal-response element DNA-binding protein M96;Metal regulatory transcription factor 2;Polycomb-like protein 2 MTF2;PCL2 Q9Y483-1;Q9Y483;Q9Y483-2 ENST00000370297;ENST00000370298;ENST00000370299 K11485 2 0.81077 1.4823 0.85032 1.1253 0.95204 1.1151 Nop;NOSIC;Prp31_C Cajal body;cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part;ribonucleoprotein complex;small nuclear ribonucleoprotein complex;spliceosomal complex binding;protein binding;ribonucleoprotein binding anatomical structure formation;assembly of spliceosomal tri-snRNP;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;ribonucleoprotein complex assembly 12 12 12 31.1 31.1 31.1 55.455 3.5912E-159 500230000 264260000 235970000 3765 IPI:IPI00292000.6;IPI:IPI00738596.2;IPI:IPI00167198.6 U4/U6 small nuclear ribonucleoprotein Prp31;Pre-mRNA-processing factor 31;U4/U6 snRNP 61 kDa protein;Serologically defined breast cancer antigen NY-BR-99 PRPF31;PRP31 Q8WWY3-1;Q8WWY3;Q8WWY3-3;Q8WWY3-2 ENST00000263436;ENST00000321030 3 1.0449 1.9949 1.0041 1.3479 1.3491 1.3046 I-set actin filament;cell part;cytoplasm;cytoskeletal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;nucleus;organelle;organelle part actin binding;actinin binding;alpha-actinin binding;binding;cytoskeletal protein binding;muscle alpha-actinin binding;protein binding cellular component organization;cellular process;cytoskeleton organization;organelle organization 5 5 5 4.2 4.2 4.2 150.54 9.5612E-36 39290000 19416000 19874000 3766 IPI:IPI00856116.1;IPI:IPI00856001.1;IPI:IPI00292009.9;IPI:IPI00855763.1;IPI:IPI00383645.3;IPI:IPI00166197.4;IPI:IPI00856046.1 Palladin;Sarcoma antigen NY-SAR-77;SIH002 PALLD;KIAA0992;CGI-151 Q8WX93-1;Q8WX93;Q8WX93-5;Q8WX93-2;Q8WX93-3;Q8WX93-4 ENST00000261509;ENST00000335742 7 0.76377 1.374 0.71423 0.96335 0.93601 0.92336 Spermine_synth catalytic activity;spermidine synthase activity;transferase activity;transferase activity, transferring alkyl or aryl (other than methyl) groups biogenic amine metabolic process;cellular amino acid and derivative metabolic process;cellular amino acid derivative metabolic process;metabolic process;nitrogen compound metabolic process;polyamine biosynthetic process;polyamine metabolic process Arginine and proline metabolism;beta-Alanine metabolism;Glutathione metabolism;Methionine metabolism 13 13 13 58.3 58.3 58.3 33.824 4.4748E-196 1333700000 710030000 623690000 3767 IPI:IPI00292020.3 Spermidine synthase;Putrescine aminopropyltransferase SRM;SPS1;SRML1 P19623 ENST00000376957 K00797 1 0.69977 1.2482 0.72301 0.93879 0.80886 1.0358 Nup_retrotrp_bd;Nup153;zf-RanBP cell part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;nucleoplasm;organelle part;pore complex;protein complex binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transition metal ion binding;transporter activity;zinc ion binding cellular process;establishment of protein localization;intracellular protein transport;intracellular transport;mRNA transport;nucleic acid transport;nucleobase, nucleoside, nucleotide and nucleic acid transport;protein transport;RNA transport;transport 14 14 14 13.6 13.6 13.6 153.94 2.9482E-137 125760000 66602000 59154000 3768 IPI:IPI00292059.2 Nuclear pore complex protein Nup153;Nucleoporin Nup153;153 kDa nucleoporin NUP153 P49790 ENST00000262077 1 0.78328 1.6241 0.77557 0.97478 1.0548 1.0166 ERG4_ERG24;LBR_tudor integral to membrane;integral to nuclear inner membrane;integral to organelle membrane;intracellular part;intrinsic to membrane;intrinsic to nuclear inner membrane;intrinsic to organelle membrane;membrane part;nuclear part;organelle part binding;catalytic activity;DNA binding;lamin binding;nucleic acid binding;oxidoreductase activity;oxidoreductase activity, acting on the CH-CH group of donors;protein binding;receptor activity;signal transducer activity 10 10 10 15.9 15.9 15.9 70.702 1.237E-96 928160000 435390000 492770000 3769 IPI:IPI00292135.1 Lamin-B receptor;Integral nuclear envelope inner membrane protein;LMN2R LBR Q14739 ENST00000272163;ENST00000338179 1 0.70903 1.7209 0.67806 0.98106 1.0417 0.94348 Peptidase_C14 cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane;membrane-bounded organelle;mitochondrion;nuclear part;nucleoplasm;organelle;organelle part;plasma membrane binding;catalytic activity;cysteine-type endopeptidase activity;cysteine-type peptidase activity;endopeptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides;protein binding catabolic process;cell structure disassembly during apoptosis;cellular component organization;macromolecule catabolic process;metabolic process;protein metabolic process;proteolysis;regulation of cell death;response to organic substance Alzheimer's disease;Amyotrophic lateral sclerosis (ALS);Apoptosis;Colorectal cancer;Epithelial cell signaling in Helicobacter pylori infection;Huntington's disease;MAPK signaling pathway;Natural killer cell mediated cytotoxicity;p53 signaling pathway;Parkinson's disease;Pathways in cancer 10 10 10 36.1 36.1 36.1 31.608 7.2645E-38 154330000 80898000 73430000 3770 IPI:IPI00292140.4 Caspase-3;Apopain;Cysteine protease CPP32;Yama protein;SREBP cleavage activity 1;Caspase-3 subunit p17;Caspase-3 subunit p12 CASP3;CPP32 P42574 ENST00000308394;ENST00000393588 K02187 1 0.73993 1.7368 0.73939 1.007 1.0032 1.0441 ASF1_hist_chap cell part;chromatin remodeling complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex binding;chromatin binding;histone binding;protein binding chromatin organization;DNA metabolic process;DNA repair;loss of chromatin silencing;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleosome assembly;regulation of chromatin assembly or disassembly;transcription 4 4 3 16.7 16.7 12.7 22.968 5.6281E-28 235690000 123970000 111720000 3771 IPI:IPI00292168.3 Histone chaperone ASF1A;Anti-silencing function protein 1 homolog A;CCG1-interacting factor A ASF1A;CGI-98;HSPC146 Q9Y294 ENST00000229595 K10753 1 0.77016 1.2983 0.69301 1.0705 0.87184 0.96673 Brix cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;nucleic acid binding;RNA binding;rRNA binding cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 6 6 6 21.8 21.8 21.8 40.11 5.0347E-83 59056000 29759000 29298000 3772 IPI:IPI00292221.3 Ribosome production factor 1;Ribosome biogenesis protein RPF1;Brix domain-containing protein 5 BXDC5;RPF1 Q9H9Y2 ENST00000370654 1 0.45969 0.96669 0.3986 0.59274 0.61086 0.527 Pkinase cell part;cytoplasmic part;cytosol;intracellular part ATP binding;binding;catalytic activity;glycogen synthase kinase 3 activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding cell communication;cell surface receptor linked signal transduction;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;regulation of carbohydrate metabolic process;signal transduction Chemokine signaling pathway 7 5 5 22.6 19.5 19.5 50.98 4.3766E-78 24576000 13732000 10844000 3773 IPI:IPI00292228.1 Glycogen synthase kinase-3 alpha GSK3A P49840 ENST00000222330 K08822 1 0.91239 1.4828 0.99601 1.1342 1.0072 1.2426 zf-C3HC4 binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding 5 5 5 28.8 28.8 28.8 17.909 1.7911E-13 117780000 53403000 64376000 3774 IPI:IPI00292354.8 E3 ubiquitin-protein ligase RNF181;RING finger protein 181 RNF181;HSPC238 Q9P0P0 ENST00000306368 1 0.8595 1.6171 0.78625 1.1029 1.0618 1.0874 C1_1;RhoGAP cell part;intracellular binding;diacylglycerol binding;enzyme activator activity;enzyme regulator activity;GTPase activator activity;lipid binding;protein binding;Ras GTPase activator activity;Rho GTPase activator activity;small GTPase regulator activity;zinc ion binding cell communication;cellular process;intracellular signaling cascade;positive regulation of Ras GTPase activity;positive regulation of Rho GTPase activity;regulation of Ras GTPase activity;regulation of Rho GTPase activity;signal transduction 6 6 6 8.6 8.6 8.6 106.68 3.5278E-150 12359000 6707900 5650600 3775 IPI:IPI00292376.4 GEM-interacting protein GMIP Q9P107 ENST00000203556 1 0.5031 1.2357 0.58043 0.6715 0.73434 0.76308 DCP2;NUDIX cell part;cytoplasmic mRNA processing body;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;ribonucleoprotein complex binding;catalytic activity;cation binding;hydrolase activity;ion binding;manganese ion binding;metal ion binding;nucleic acid binding;protein binding;RNA binding;transition metal ion binding mRNA catabolic process;nuclear-transcribed mRNA catabolic process;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA catabolic process 5 5 5 17.1 17.1 17.1 48.457 4.0637E-11 28356000 14702000 13655000 3776 IPI:IPI00292382.6;IPI:IPI00440151.2 mRNA-decapping enzyme 2;Nucleoside diphosphate-linked moiety X motif 20 DCP2;NUDT20 Q8IU60-1;Q8IU60;Q8IU60-2 ENST00000389063;ENST00000389064 K01567 2 NaN 1.6164 NaN NaN 1.1217 NaN PHD;zf-CXXC cell part;intracellular organelle part;intracellular part;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;sequence-specific DNA binding;transcription activator activity;transcription regulator activity;unmethylated CpG binding;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 5 5 5 9.5 9.5 9.5 75.711 1.6509E-47 34955000 16858000 18097000 3777 IPI:IPI00292445.7 CpG-binding protein;PHD finger and CXXC domain-containing protein 1;CXXC-type zinc finger protein 1 CXXC1;CFP1;CGBP;PCCX1;PHF18 Q9P0U4 ENST00000285106 1 0.69734 1.1674 NaN 1.0723 0.71093 NaN BACK;BTB;Kelch_1 binding;protein binding 3 3 3 6.1 6.1 6.1 70.358 2.8257E-30 647340 400260 247090 3778 IPI:IPI00292468.6 Kelch-like protein 6 KLHL6 Q8WZ60 ENST00000341319;ENST00000392603 K10444 1 0.83268 1.4767 0.81034 1.0542 0.93093 1.0267 Tubulin;Tubulin_C cell part;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;microtubule;organelle part;protein complex binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;pyrophosphatase activity;structural molecule activity anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;microtubule-based movement;microtubule-based process;protein complex assembly Gap junction 11 1 1 21.6 3.8 3.8 49.775 5.2119E-195 413070000 225980000 187090000 3779 IPI:IPI00292496.1 Tubulin beta-8 chain TUBB8 Q3ZCM7 ENST00000309812 K07375 1 0.76687 1.4574 0.68795 1.0087 0.9721 0.93139 HSP70 adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding 15 15 15 33.4 33.4 33.4 54.794 4.4607E-284 332500000 178860000 153640000 3780 IPI:IPI00292499.4 Heat shock 70 kDa protein 14;Heat shock protein HSP60;HSP70-like protein 1 HSPA14;HSP60;HSP70L1 Q0VDF9 ENST00000378372 1 0.89163 1.9743 0.91022 1.1361 1.3339 1.2128 Ank;Death;RHD;TIG cell part;cytoplasmic part;cytosol;I-kappaB/NF-kappaB complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;protein complex binding;DNA binding;nucleic acid binding;promoter binding;sequence-specific DNA binding;transcription factor activity;transcription regulator activity negative regulation of transcription from RNA polymerase II promoter;positive regulation of myeloid leukocyte differentiation;regulation of immune system process;regulation of myeloid leukocyte differentiation Acute myeloid leukemia;Adipocytokine signaling pathway;Apoptosis;B cell receptor signaling pathway;Chemokine signaling pathway;Chronic myeloid leukemia;Epithelial cell signaling in Helicobacter pylori infection;MAPK signaling pathway;Pancreatic cancer;Pathways in cancer;Prostate cancer;Small cell lung cancer;T cell receptor signaling pathway;Toll-like receptor signaling pathway 12 12 12 16.7 16.7 16.7 105.43 4.9905E-253 250400000 132140000 118260000 3781 IPI:IPI00292537.3;IPI:IPI00788987.1 Nuclear factor NF-kappa-B p105 subunit;DNA-binding factor KBF1;EBP-1;Nuclear factor NF-kappa-B p50 subunit NFKB1 P19838-2;P19838;P19838-1 ENST00000226574;ENST00000394820 K02580 2 0.76656 1.504 0.75365 0.98851 1.0087 0.98894 RasGAP;VPS9 cell part;cytoplasmic part;cytosol;endosome;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;organelle binding;enzyme activator activity;enzyme regulator activity;GTPase activating protein binding;GTPase activator activity;GTPase regulator activity;guanyl-nucleotide exchange factor activity;nucleoside-triphosphatase regulator activity;protein binding cell communication;cellular component organization;cellular process;endocytosis;membrane invagination;membrane organization;regulation of cell communication;regulation of signal transduction;signal transduction;transport;vesicle-mediated transport 23 23 23 20.4 20.4 20.4 166.17 4.9761E-250 417000000 223940000 193060000 3782 IPI:IPI00292753.7;IPI:IPI00888069.1;IPI:IPI00873087.1;IPI:IPI00302156.6;IPI:IPI00883910.1;IPI:IPI00852719.3 GTPase-activating protein and VPS9 domain-containing protein 1;Rab5-activating protein 6;GAPex-5 GAPVD1;GAPEX5;KIAA1521;RAP6 Q14C86-6;Q14C86;Q14C86-1;Q14C86-2;Q14C86-5;Q14C86-4;Q14C86-3 ENST00000265956;ENST00000297933;ENST00000394104;ENST00000394105 6 0.47976 NaN NaN 0.70274 NaN NaN Actin adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 2 2 2 5.3 5.3 5.3 68.297 1.3151E-25 5732200 3673900 2058300 3783 IPI:IPI00292787.6 Actin-related protein 5;Sarcoma antigen NY-SAR-16 ACTR5;ARP5 Q9H9F9 ENST00000243903 K11672 1 0.70491 1.3805 0.69823 0.95022 0.98323 0.92353 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 6 6 6 19.7 19.7 19.7 46.487 1.9789E-38 151130000 80218000 70907000 3784 IPI:IPI00292812.6 Protein TMED8 TMED8;FAM15B;L10 Q6PL24 ENST00000216468 1 0.74434 1.4235 0.67497 0.96732 0.89067 0.92374 Pkinase cell part;cytoplasmic part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle ATP binding;binding;catalytic activity;kinase activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity apoptosis;cell death;cellular process;death;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;programmed cell death;protein amino acid phosphorylation;protein modification process;regulation of cell death 16 9 7 46.9 34.6 27.9 46.528 0 428720000 230700000 198020000 3785 IPI:IPI00292827.3 Serine/threonine-protein kinase MST4;Mammalian STE20-like protein kinase 4;STE20-like kinase MST4;Serine/threonine-protein kinase MASK;Mst3 and SOK1-related kinase MST4;MASK Q9P289 ENST00000370887;ENST00000394334 1 1.0707 NaN 0.80629 1.3066 NaN 1.1349 E2F_TDP cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex binding;DNA binding;nucleic acid binding;protein binding;transcription factor activity;transcription regulator activity biosynthetic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription TGF-beta signaling pathway 4 4 4 11.4 11.4 11.4 43.96 1.8609E-09 70352000 34393000 35959000 3786 IPI:IPI00292880.5 Transcription factor E2F4 E2F4 Q16254 ENST00000379378 K04682 1 0.67061 1.2978 0.63164 0.89167 0.8358 0.80724 AARP2CN;DUF663 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;protein binding anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex assembly;cellular macromolecular complex subunit organization;cellular process;ribonucleoprotein complex assembly;ribosome assembly 11 11 11 18.3 18.3 18.3 91.809 1.0086E-181 267560000 146500000 121060000 3787 IPI:IPI00292894.5 Pre-rRNA-processing protein TSR1 homolog TSR1;KIAA1401 Q2NL82 ENST00000301364 1 0.9229 1.7912 NaN 1.2079 1.1731 NaN zf-CCCH cell part;cytoplasm;intracellular organelle part;intracellular part;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part binding;cation binding;ion binding;metal ion binding;nucleic acid binding;nucleotide binding;RNA binding;transition metal ion binding;zinc ion binding 10 9 9 12.7 11.6 11.6 118.72 2.722E-66 54617000 28117000 26500000 3789 IPI:IPI00292975.4 RNA-binding protein 27;RNA-binding motif protein 27 RBM27;KIAA1311 Q9P2N5 ENST00000265271 1 0.866 1.5671 0.76617 1.1728 1.0228 1.0369 Rab5-bind;Rabaptin cell part;cytoplasmic part;early endosome;endosome;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle;recycling endosome binding;enzyme activator activity;enzyme regulator activity;growth factor activity;GTPase activator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity;protein binding;receptor binding apoptosis;cell death;cellular component organization;cellular process;death;endocytosis;membrane fusion;membrane invagination;membrane organization;programmed cell death;protein transport;transport;vesicle-mediated transport 11 11 11 13.5 13.5 13.5 99.289 1.9411E-164 49384000 25688000 23696000 3790 IPI:IPI00293009.4;IPI:IPI00412712.2 Rab GTPase-binding effector protein 1;Rabaptin-5;Rabaptin-5alpha;Rabaptin-4;Renal carcinoma antigen NY-REN-17 RABEP1;RABPT5;RABPT5A Q15276-1;Q15276;Q15276-2 ENST00000262477;ENST00000341923;ENST00000408982 2 0.72675 1.4846 0.70541 0.95014 0.97071 0.92301 EFG_C;EFG_IV;GTP_EFTU binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;nucleic acid binding;nucleotide binding;pyrophosphatase activity;translation elongation factor activity;translation factor activity, nucleic acid binding biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 8 8 8 7.5 7.5 7.5 125.43 1.3434E-26 99298000 52440000 46858000 3792 IPI:IPI00293026.7;IPI:IPI00759768.1;IPI:IPI00878078.1 Elongation factor Tu GTP-binding domain-containing protein 1 EFTUD1 Q7Z2Z2-1;Q7Z2Z2;Q7Z2Z2-2;Q7Z2Z2-3 ENST00000268206;ENST00000359445 K03234 3 NaN 1.4956 0.76828 NaN 1.0549 1.0235 Dynamin_N;Fzo_mitofusin cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial membrane;mitochondrial outer membrane;mitochondrial part;organelle membrane;organelle outer membrane;organelle part;outer membrane binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleotide binding;pyrophosphatase activity anatomical structure morphogenesis;cellular component morphogenesis;cellular component organization;cellular process;developmental process;membrane fusion;membrane organization;mitochondrial fusion;mitochondrion organization;organelle organization 3 3 1 5.1 5.1 1.8 86.993 9.8975E-50 1958400 1023200 935200 3793 IPI:IPI00293073.4;IPI:IPI00395973.3 Mitofusin-1;Transmembrane GTPase MFN1;Fzo homolog MFN1 Q8IWA4-1;Q8IWA4 ENST00000263969;ENST00000280653;ENST00000357390 K06030 2 0.76989 1.3953 0.74632 0.99471 0.91982 0.9636 DEAD;Helicase_C cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;ATP-dependent helicase activity;binding;catalytic activity;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity 16 16 16 20.6 20.6 20.6 89.834 1.5632E-98 357870000 187890000 169990000 3794 IPI:IPI00293078.1 Probable ATP-dependent RNA helicase DDX27;DEAD box protein 27 DDX27;RHLP;HSPC259;PP3241 Q96GQ7 ENST00000371764 1 0.72768 1.4463 0.7189 0.96215 0.95716 0.95378 Glyco_hydro_31;Trefoil cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;lysosome;lytic vacuole;membrane-bounded organelle;organelle;vacuole alpha-glucosidase activity;binding;carbohydrate binding;catalytic activity;glucosidase activity;hydrolase activity;hydrolase activity, acting on glycosyl bonds;hydrolase activity, hydrolyzing O-glycosyl compounds;sugar binding carbohydrate metabolic process;diaphragm contraction;involuntary skeletal muscle contraction;maltose metabolic process;muscle system process;polysaccharide catabolic process;respiratory system process;skeletal muscle contraction;system process Galactose metabolism;Starch and sucrose metabolism 10 10 10 14.7 14.7 14.7 105.32 5.885E-167 280950000 148820000 132130000 3795 IPI:IPI00293088.6 Lysosomal alpha-glucosidase;Acid maltase;Aglucosidase alfa;76 kDa lysosomal alpha-glucosidase;70 kDa lysosomal alpha-glucosidase GAA P10253 ENST00000302262;ENST00000390015 K12316 1 0.90261 1.6077 0.99724 1.1605 1.0726 1.2213 PTPA calcium channel complex;cation channel complex;cell fraction;ion channel complex;macromolecular complex;membrane-bounded organelle;nucleus;organelle;protein phosphatase type 2A complex;protein serine/threonine phosphatase complex;soluble fraction ATP binding;binding;enzyme activator activity;nucleoside binding;nucleotide binding;protein binding;protein phosphatase type 2A regulator activity;protein tyrosine phosphatase activator activity;purine nucleoside binding;receptor binding negative regulation of metabolic process;negative regulation of phosphorus metabolic process;positive regulation of macromolecule metabolic process;positive regulation of metabolic process;positive regulation of phosphorus metabolic process 10 10 10 34 34 34 41.757 4.3271E-180 133720000 70006000 63710000 3796 IPI:IPI00893197.1;IPI:IPI00293102.4;IPI:IPI00217296.2;IPI:IPI00217297.1 Serine/threonine-protein phosphatase 2A regulatory subunit B';PP2A, subunit B', PR53 isoform;Phosphotyrosyl phosphatase activator PPP2R4;PTPA Q15257-2;Q15257;Q15257-1;Q15257-3;Q15257-4 ENST00000337738;ENST00000355007;ENST00000357197;ENST00000358994;ENST00000393370;ENST00000405725 4 0.91457 1.6354 0.96858 1.1987 1.0763 1.2697 CAP_GLY cell part;cytoplasm;cytoskeletal part;intracellular organelle part;intracellular part;microtubule;organelle part binding;protein binding anatomical structure development;cell differentiation;cellular developmental process;cellular process;developmental process;nervous system development;system development 10 10 10 36.1 36.1 36.1 27.325 7.7738E-117 810560000 399680000 410880000 3797 IPI:IPI00293126.1 Tubulin folding cofactor B;Tubulin-specific chaperone B;Cytoskeleton-associated protein 1;Cytoskeleton-associated protein CKAPI TBCB;CG22;CKAP1 Q99426 ENST00000221855 1 1.5095 2.8228 1.2621 1.8772 1.8899 1.6946 Siva cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;CD27 receptor binding;cytokine receptor binding;ion binding;protein binding;receptor activity;receptor binding;signal transducer activity;tumor necrosis factor receptor superfamily binding;viral receptor activity;zinc ion binding apoptosis;cell death;cellular process;death;induction of apoptosis;induction of programmed cell death;positive regulation of apoptosis;positive regulation of cell death;programmed cell death;regulation of apoptosis;regulation of cell death 5 5 5 31.4 31.4 31.4 18.695 6.2008E-137 46800000 22409000 24391000 3798 IPI:IPI00293157.4;IPI:IPI00747156.1 Apoptosis regulatory protein Siva;CD27-binding protein SIVA1;SIVA O15304-1;O15304 ENST00000329967;ENST00000347067 2 1.6438 1.4495 NaN 2.158 0.97058 NaN CH;efhand;GAS2;Plectin;Spectrin basement membrane;cell junction;cell-substrate junction;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;cytoskeleton;hemidesmosome;membrane-bounded organelle;membrane-bounded vesicle;non-membrane-bounded organelle;organelle;vesicle actin binding;actin filament binding;binding;calcium ion binding;cation binding;cytoskeletal protein binding;integrin binding;ion binding;metal ion binding;protein binding;protein complex binding;protein C-terminus binding;receptor binding biological adhesion;cell adhesion;cell communication;cell surface receptor linked signal transduction;cellular component organization;cellular process;cytoskeleton organization;integrin-mediated signaling pathway;organelle organization;signal transduction 5 4 3 1.2 1 0.8 632.52 2.7118E-87 6364000 3252400 3111600 3799 IPI:IPI00921479.1;IPI:IPI00293251.5;IPI:IPI00654639.2;IPI:IPI00015631.3 Bullous pemphigoid antigen 1, isoforms 1/2/3/4/5/8;230 kDa bullous pemphigoid antigen;Hemidesmosomal plaque protein;Dystonia musculorum protein;Bullous pemphigoid antigen 1, isoforms 6/9/10;Trabeculin-beta DST;BPAG1;DMH;DT;KIAA0728 Q03001-1;Q03001;O94833-2;O94833;O94833-3 ENST00000281662;ENST00000370765;ENST00000370769;ENST00000244364 K10382 4 0.70721 1.5862 0.71838 1.1035 0.92528 0.90532 DnaJ;Thioredoxin endoplasmic reticulum;endoplasmic reticulum lumen;extracellular region;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;membrane-enclosed lumen;organelle;organelle lumen;organelle part binding;heat shock protein binding;protein binding;unfolded protein binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular homeostasis;cellular metabolic process;cellular process;homeostatic process;macromolecule metabolic process;metabolic process;protein folding;protein metabolic process 6 6 6 8.3 8.3 8.3 91.079 3.8856E-30 46095000 26211000 19885000 3800 IPI:IPI00293260.5;IPI:IPI00844115.1 DnaJ homolog subfamily C member 10;ER-resident protein ERdj5;Macrothioredoxin DNAJC10;ERDJ5;UNQ495/PRO1012 Q8IXB1-1;Q8IXB1;Q8IXB1-2 ENST00000264065;ENST00000392392 K09530 2 0.92502 1.4007 0.93747 1.1458 1.0145 1.1395 MIF extracellular region part;extracellular space binding;catalytic activity;cytokine activity;intramolecular oxidoreductase activity;intramolecular oxidoreductase activity, interconverting keto- and enol-groups;isomerase activity;phenylpyruvate tautomerase activity;protein binding;receptor binding fatty acid biosynthetic process;fatty acid metabolic process;lipid metabolic process;organic acid metabolic process;prostaglandin biosynthetic process;regulation of immune system process;regulation of leukocyte activation Phenylalanine metabolism;Tyrosine metabolism 4 4 4 36.5 36.5 36.5 12.476 4.5583E-45 4626800000 2310300000 2316500000 3801 IPI:IPI00293276.10 Macrophage migration inhibitory factor;Phenylpyruvate tautomerase;L-dopachrome tautomerase;L-dopachrome isomerase;Glycosylation-inhibiting factor MIF;GLIF;MMIF P14174 ENST00000215754 K07253 1 NaN 1.5956 1.1282 NaN 1.1535 1.39 Peptidase_C13 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;lysosome;lytic vacuole;membrane-bounded organelle;organelle;vacuole catalytic activity;cysteine-type endopeptidase activity;cysteine-type peptidase activity;endopeptidase activity;kinase activity;peptidase activity;protein kinase activity;protein serine/threonine kinase activity;transferase activity Antigen processing and presentation 2 2 2 5.8 5.8 5.8 49.411 2.3743E-14 50686000 26079000 24606000 3802 IPI:IPI00293303.1 Legumain;Asparaginyl endopeptidase;Protease, cysteine 1 LGMN;PRSC1 Q99538 ENST00000334869;ENST00000393218 K01369 1 0.84336 1.5607 0.78234 1.044 0.9995 1.1413 zf-CCCH cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding 5 5 5 5.9 5.9 5.9 106.38 5.324E-80 256190000 126110000 130090000 3803 IPI:IPI00328929.4;IPI:IPI00293312.6 Zinc finger CCCH domain-containing protein 18;Nuclear protein NHN1 ZC3H18;NHN1 Q86VM9-1;Q86VM9;Q86VM9-2 ENST00000289509;ENST00000301011 2 0.56799 1.3379 0.57254 0.7656 0.88678 0.75994 POP1;POPLD intracellular part;macromolecular complex;multimeric ribonuclease P complex;nuclear part;nucleolar ribonuclease P complex;organelle part;ribonuclease MRP complex;ribonuclease P complex;ribonucleoprotein complex;small nucleolar ribonucleoprotein complex binding;catalytic activity;endonuclease activity;endoribonuclease activity;hydrolase activity;nuclease activity;protein binding;ribonuclease activity;ribonuclease MRP activity;ribonuclease P activity;tRNA-specific ribonuclease activity catabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA catabolic process;RNA processing;tRNA 5'-leader removal;tRNA metabolic process;tRNA processing 13 13 13 16 16 16 114.71 1.0745E-164 192120000 109270000 82855000 3804 IPI:IPI00293331.3 Ribonucleases P/MRP protein subunit POP1 POP1;KIAA0061 Q99575 ENST00000349693;ENST00000401707 1 0.66783 1.2744 0.58506 0.91298 0.843 0.76395 Lactamase_B binding;catalytic activity;cation binding;hydrolase activity;ion binding;metal ion binding;transition metal ion binding;zinc ion binding 7 7 7 23.7 23.7 23.7 31.341 3.572E-14 61293000 33440000 27853000 3805 IPI:IPI00293336.5;IPI:IPI00888973.1 Metallo-beta-lactamase domain-containing protein 2 MBLAC2 Q68D91-1;Q68D91 ENST00000316610 2 0.81995 1.5315 0.91136 1.028 0.97169 1.1347 Translin cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle;perinuclear region of cytoplasm binding;DNA binding;nucleic acid binding;protein transporter activity;sequence-specific DNA binding;substrate-specific transporter activity;transporter activity cell differentiation;cellular developmental process;cellular process;developmental process;gamete generation;male gamete generation;multicellular organismal development;multicellular organismal process;reproductive process;spermatogenesis 13 13 13 60 60 60 33.112 0 393560000 200650000 192910000 3806 IPI:IPI00293350.3 Translin-associated protein X;Translin-associated factor X TSNAX;TRAX Q99598 ENST00000366639 1 0.74381 1.3447 0.7369 0.9921 0.88416 0.89943 BRK;Bromodomain;Helicase_C;HSA;QLQ;SNF2_N cell part;chromatin remodeling complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex;SWI/SNF complex;SWI/SNF-type complex ATP binding;binding;catalytic activity;DNA binding;DNA-dependent ATPase activity;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;p53 binding;protein binding;purine nucleoside binding;pyrophosphatase activity chromatin organization;chromatin remodeling;negative regulation of transcription from RNA polymerase II promoter;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 27 27 15 17.9 17.9 11.4 184.64 0 709400000 381240000 328160000 3808 IPI:IPI00293426.2;IPI:REV_IPI00171093.3;IPI:REV_IPI00735492.1;IPI:REV_IPI00640927.1;IPI:REV_IPI00916634.1 Probable global transcription activator SNF2L4;ATP-dependent helicase SMARCA4;SNF2-beta;BRG-1 protein;Mitotic growth and transcription activator;Brahma protein homolog 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 SMARCA4;BRG1;SNF2B;SNF2L4 P51532 ENST00000344626;ENST00000358026 K11647 5 1.0109 1.5184 1.0055 1.2738 1.0698 1.282 SRP14 cell part;cytoplasmic part;intracellular part;macromolecular complex;ribonucleoprotein complex;signal recognition particle;signal recognition particle, endoplasmic reticulum targeting 7S RNA binding;binding;endoplasmic reticulum signal peptide binding;nucleic acid binding;peptide binding;protein binding;RNA binding;signal sequence binding cotranslational protein targeting to membrane;protein targeting;protein targeting to membrane;regulation of translation;regulation of translational elongation;SRP-dependent cotranslational protein targeting to membrane;transport Protein export 8 8 8 41.2 41.2 41.2 14.57 5.0947E-196 1046600000 525880000 520750000 3810 IPI:IPI00293434.2 Signal recognition particle 14 kDa protein;18 kDa Alu RNA-binding protein SRP14 P37108 ENST00000267884 K03104 1 0.59843 1.0352 0.59181 0.78653 0.69124 0.76953 CPSF_A cell part;cytoplasm;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;damaged DNA binding;DNA binding;nucleic acid binding;protein binding cell cycle checkpoint;DNA catabolic process;DNA metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleotide-excision repair, DNA damage removal;protein modification process Nucleotide excision repair;Ubiquitin mediated proteolysis 42 42 42 41.8 41.8 41.8 126.97 0 4409600000 2452500000 1957100000 3811 IPI:IPI00293464.5 DNA damage-binding protein 1;Damage-specific DNA-binding protein 1;UV-damaged DNA-binding factor;DDB p127 subunit;DNA damage-binding protein a;UV-damaged DNA-binding protein 1;Xeroderma pigmentosum group E-complementing protein;XPE-binding factor;HBV X-associated protein 1 DDB1;XAP1 Q16531 ENST00000301764 K10610 1 0.7495 1.6286 0.79499 0.89585 1.1607 0.97476 Ribosomal_L23 cytoplasmic part;intracellular part;large ribosomal subunit;macromolecular complex;mitochondrial large ribosomal subunit;mitochondrial part;organellar large ribosomal subunit;organelle part;ribonucleoprotein complex;ribosomal subunit binding;nucleic acid binding;nucleotide binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 3 3 3 30.7 30.7 30.7 17.781 2.8299E-137 76136000 39113000 37023000 3812 IPI:IPI00293476.3 39S ribosomal protein L23, mitochondrial;L23 mitochondrial-related protein;Ribosomal protein L23-like MRPL23;L23MRP;RPL23L Q16540 ENST00000381519;ENST00000381526;ENST00000397297 1 0.62841 1.2958 0.59285 0.83227 0.80517 0.81501 Nsp1_C centrosome;macromolecular complex;membrane;microtubule organizing center;non-membrane-bounded organelle;nuclear membrane;nuclear pore;nucleocytoplasmic shuttling complex;nucleolus;organelle;organelle membrane;ribonucleoprotein complex binding;catalytic activity;chromatin binding;kinase activity;protein binding;protein kinase activity;protein serine/threonine kinase activity;receptor binding;structural molecule activity;transcription factor binding;transferase activity cell communication;cell death;cell surface receptor linked signal transduction;intracellular protein transport;intracellular signaling cascade;negative regulation of cell proliferation;response to endogenous stimulus;signal transduction;transport 7 7 7 19.2 19.2 19.2 53.254 5.8433E-25 207290000 121840000 85452000 3813 IPI:IPI00293533.4 Nuclear pore glycoprotein p62;62 kDa nucleoporin NUP62 P37198 ENST00000352066;ENST00000391824 1 0.84328 1.6848 0.92957 1.1317 1.0803 1.2405 HMGL-like cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part binding;carbon-carbon lyase activity;catalytic activity;cation binding;hydroxymethylglutaryl-CoA lyase activity;ion binding;lyase activity;metal ion binding;oxo-acid-lyase activity metabolic process Butanoate metabolism;Synthesis and degradation of ketone bodies;Valine, leucine and isoleucine degradation 6 6 6 22.2 22.2 22.2 34.36 1.5265E-126 28636000 15590000 13046000 3814 IPI:IPI00293564.5 Hydroxymethylglutaryl-CoA lyase, mitochondrial;3-hydroxy-3-methylglutarate-CoA lyase HMGCL P35914 ENST00000374490 K01640 1 NaN 1.1653 0.53008 NaN 0.67314 0.74389 Pkinase cell part;cytoplasmic part;cytosol;intracellular part ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cell communication;defense response;immune response;immune system process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;response to stress;signal transduction Toll-like receptor signaling pathway 3 3 3 6 6 6 83.641 1.3333E-57 6969700 2320200 4649500 3815 IPI:IPI00293613.2 Serine/threonine-protein kinase TBK1;TANK-binding kinase 1;T2K;NF-kappa-B-activating kinase TBK1;NAK Q9UHD2 ENST00000331710 K05410 1 0.81657 1.4583 0.80524 1.0464 0.98495 1.0038 DEAD;Helicase_C;SPRY cell part;intracellular part;macromolecular complex;ribonucleoprotein complex ATP binding;ATP-dependent helicase activity;binding;catalytic activity;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity;RNA binding;RNA helicase activity cellular process;multicellular organismal development;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of translation;regulation of translational initiation;spliceosome assembly 37 37 37 58.9 58.9 58.9 82.431 0 2290000000 1207900000 1082200000 3817 IPI:IPI00293655.3 ATP-dependent RNA helicase DDX1;DEAD box protein 1;DEAD box protein retinoblastoma DDX1 Q92499 ENST00000233084;ENST00000381341 1 1.0029 1.698 1.1473 1.4286 0.97652 1.6296 IRF cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;RNA polymerase II transcription factor activity;transcription factor activity;transcription regulator activity negative regulation of transcription from RNA polymerase II promoter;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 2 2 2 8 8 8 39.354 4.6267E-21 20122000 7318800 12803000 3818 IPI:IPI00293657.3 Interferon regulatory factor 2 IRF2 P14316 ENST00000393593 K10153 1 0.089453 19.489 0.09516 0.11925 12.82 0.12144 Filament cell part;cytoskeletal part;intermediate filament;intracellular organelle part;intracellular part;keratin filament;organelle part structural constituent of cytoskeleton;structural molecule activity anatomical structure development;developmental process;ectoderm development;tissue development + 37 23 1 57.1 38.1 1.6 60.066 0 862840000 834380000 28459000 3819 IPI:IPI00293665.9 Keratin, type II cytoskeletal 6B;Cytokeratin-6B;K6b keratin KRT6B;K6B;KRTL1 P04259 ENST00000252252 K07605 1 0.47177 1.02 0.48389 0.64557 0.69325 0.65099 IKI3 cytoplasm;DNA-directed RNA polymerase II, holoenzyme;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nucleolus;organelle;protein complex;transcription elongation factor complex binding;enzyme regulator activity;kinase regulator activity;molecular transducer activity;phosphorylase kinase regulator activity;protein binding;protein kinase regulator activity;signal transducer activity immune system process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein complex assembly;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 20 20 20 19.7 19.7 19.7 150.25 1.1438E-157 178840000 100940000 77899000 3820 IPI:IPI00293735.2 Elongator complex protein 1;IkappaB kinase complex-associated protein;p150 IKBKAP;ELP1;IKAP O95163 ENST00000374647 K11373 1 0.5743 1.2309 0.61024 0.75838 0.8943 0.83246 MMtag 5 5 5 17.1 17.1 17.1 29.411 6.7719E-38 156860000 81801000 75059000 3821 IPI:IPI00293746.2;IPI:IPI00642240.1;IPI:IPI00646155.1;IPI:IPI00446669.1 Multiple myeloma tumor-associated protein 2 MMTAG2;C1orf35 Q9BU76-1;Q9BU76;Q9BU76-4;Q9BU76-3;Q9BU76-2 ENST00000272139;ENST00000366749 4 0.90043 1.3979 0.98571 1.222 0.90933 1.2454 Acid_phosphat_A endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;membrane-enclosed lumen;organelle;organelle lumen;organelle part acid phosphatase activity;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;inositol or phosphatidylinositol phosphatase activity;multiple inositol-polyphosphate phosphatase activity;phosphohistidine phosphatase activity biomineral formation;bone mineralization;cellular metabolic process;cellular process;developmental process;metabolic process;phosphate metabolic process;phosphorus metabolic process;polyphosphate metabolic process;tissue development Inositol phosphate metabolism 4 4 4 9.9 9.9 9.9 55.051 4.2784E-38 9768400 4948300 4820200 3822 IPI:IPI00293748.3;IPI:IPI00028553.1;IPI:IPI00607763.1 Multiple inositol polyphosphate phosphatase 1;Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase;Ins(1,3,4,5)P(4) 3-phosphatase MINPP1;MIPP;UNQ900/PRO1917 Q9UNW1-1;Q9UNW1;Q9UNW1-2;Q9UNW1-3 ENST00000371994;ENST00000371996;ENST00000394408 K03103 3 NaN 1.438 0.78484 NaN 0.96895 0.99414 Synaptobrevin cell part;cytoplasmic part;endomembrane system;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle cell differentiation;cellular developmental process;cellular process;developmental process;establishment of localization;transport;vesicle-mediated transport SNARE interactions in vesicular transport 2 2 2 22.4 22.4 22.4 12.805 2.5898E-79 48197000 25530000 22666000 3823 IPI:IPI00293756.5 Vesicle-associated membrane protein 5;Myobrevin VAMP5;HSPC191 O95183 ENST00000306384 K08514 1 0.82876 1.5937 0.82164 1.1201 1.0098 1.0798 NSF cell fraction;cytoplasmic part;endoplasmic reticulum;Golgi apparatus;insoluble fraction;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane fraction;membrane-bounded organelle;mitochondrion;organelle binding;protein binding cellular process;intracellular protein transport;intra-Golgi vesicle-mediated transport;membrane fusion;metabolic process;posttranscriptional regulation of gene expression;protein complex assembly;regulation of gene expression;transport 11 11 11 32.7 32.7 32.7 34.746 4.7833E-135 238420000 119210000 119210000 3824 IPI:IPI00293817.3 Gamma-soluble NSF attachment protein;N-ethylmaleimide-sensitive factor attachment protein gamma NAPG;SNAPG Q99747 ENST00000322897 1 0.42851 0.80653 0.47428 0.56954 0.51711 0.61358 cell part;chromosomal part;chromosome, telomeric region;intracellular organelle part;intracellular part;organelle part binding cell cycle;cellular process;response to DNA damage stimulus;response to stimulus;response to stress 16 16 16 8.2 8.2 8.2 274.46 1.3522E-130 121280000 70404000 50875000 3825 IPI:IPI00293845.5;IPI:IPI00375454.8 Telomere-associated protein RIF1;Rap1-interacting factor 1 homolog RIF1 Q5UIP0-1;Q5UIP0;Q5UIP0-2 ENST00000243326;ENST00000336130;ENST00000359799 K11138 2 0.80181 1.7358 0.91133 1.0769 1.1223 1.2611 MIF cell part;cytoplasm;intracellular part binding;carbon-carbon lyase activity;carboxy-lyase activity;catalytic activity;dopachrome isomerase activity;intramolecular oxidoreductase activity;isomerase activity;lyase activity;protein binding cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;melanin biosynthetic process from tyrosine;melanin metabolic process;organic acid metabolic process;tyrosine metabolic process 5 5 5 49.2 49.2 49.2 12.712 1.0865E-57 280120000 146860000 133270000 3827 IPI:IPI00293867.7;IPI:IPI00472043.3 D-dopachrome decarboxylase;D-dopachrome tautomerase;Phenylpyruvate tautomerase II;D-dopachrome decarboxylase-like protein;D-dopachrome tautomerase-like protein DDT;DDTL P30046;A6NHG4 ENST00000350608;ENST00000398344;ENST00000403754;ENST00000404092;ENST00000215770 K10028 2 0.093637 1.981 NaN 0.1243 1.2283 NaN BRCT cell part;intracellular organelle part;intracellular part;nuclear body;nuclear part;nucleoplasm part;organelle part;PML body binding;DNA binding;nucleic acid binding;protein binding;protein C-terminus binding DNA metabolic process;DNA repair;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to DNA damage stimulus;response to radiation;response to stress + 2 2 2 1.8 1.8 1.8 170.68 1.9838E-08 129390000 72468000 56925000 3828 IPI:IPI00293921.3 DNA topoisomerase 2-binding protein 1;DNA topoisomerase II-binding protein 1;DNA topoisomerase IIbeta-binding protein 1 TOPBP1;KIAA0259 Q92547 ENST00000260810 1 0.61914 1.1358 0.51675 0.83319 0.73773 0.70308 condensed chromosome kinetochore;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;kinetochore;macromolecular complex;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle binding;protein binding;protein N-terminus binding cell cycle checkpoint;cytoskeleton organization;microtubule cytoskeleton organization;microtubule-based process;mitotic cell cycle checkpoint;mitotic sister chromatid segregation;organelle organization;sister chromatid segregation;spindle organization 2 2 2 7.6 7.6 7.6 31.293 7.9468E-19 32067000 16194000 15873000 3830 IPI:IPI00294008.4 ZW10 interactor;ZW10-interacting protein 1 ZWINT O95229 ENST00000373944;ENST00000395405 1 NaN 2.0738 NaN NaN 1.3111 NaN CBS;Voltage_CLC endosome membrane;Golgi membrane;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane;membrane-bounded organelle;mitochondrion;non-membrane-bounded organelle;nucleolus;organelle;organelle membrane anion channel activity;anion transmembrane transporter activity;binding;chloride channel activity;ion channel activity;transporter activity;voltage-gated anion channel activity;voltage-gated chloride channel activity;voltage-gated ion channel activity anion transport;chloride transport;establishment of localization;excretion;inorganic anion transport;ion transport;multicellular organismal process;secretion;system process;transport 2 2 2 2.7 2.7 2.7 85.27 0.0022763 3154300 307020 2847200 3831 IPI:IPI00294056.4 H(+)/Cl(-) exchange transporter 5;Chloride transporter ClC-5;Chloride channel protein 5 CLCN5;CLCK2 P51795 ENST00000307367;ENST00000376088;ENST00000376091;ENST00000376108 K05014 1 0.92974 1.7229 NaN 1.2321 1.1214 NaN Golgin_A5 cis-Golgi network;cytoplasmic part;Golgi apparatus part;Golgi cisterna;Golgi membrane;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part;organelle subcompartment ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein tyrosine kinase activity;purine nucleoside binding;small GTPase regulator activity;transferase activity cellular component organization;cellular process;Golgi organization;metabolic process;organelle organization;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;transport 3 3 3 6.3 6.3 6.3 82.989 1.4928E-15 10404000 5610500 4794000 3832 IPI:IPI00294065.6;IPI:IPI00333637.1 Golgin subfamily A member 5;Golgin-84;RET-fused gene 5 protein;Ret-II protein GOLGA5;RETII;RFG5 Q8TBA6-1;Q8TBA6;Q8TBA6-2 ENST00000163416;ENST00000355976 2 0.83123 1.5823 0.75949 1.0873 1.0601 0.98973 Biliv-reduc_cat;GFO_IDH_MocA cell part;cytoplasm;intracellular part biliverdin reductase activity;binding;catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on the CH-CH group of donors;oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor;zinc ion binding catabolic process;cellular nitrogen compound metabolic process;cellular process;metabolic process;nitrogen compound metabolic process;porphyrin catabolic process;porphyrin metabolic process;tetrapyrrole catabolic process;tetrapyrrole metabolic process Porphyrin and chlorophyll metabolism 15 15 15 51.4 51.4 51.4 33.428 8.1428E-175 587240000 314960000 272270000 3833 IPI:IPI00294158.1 Biliverdin reductase A;Biliverdin-IX alpha-reductase BLVRA;BLVR;BVR P53004 ENST00000265523;ENST00000402924 K00214 1 0.71719 1.4829 0.74627 0.987 0.96879 0.92565 Mito_carr cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part binding;citrate transmembrane transporter activity;organic acid transmembrane transporter activity;protein binding;transmembrane transporter activity;transporter activity;tricarboxylic acid transmembrane transporter activity anion transport;carboxylic acid transport;citrate transport;intracellular transport;ion transport;mitochondrial citrate transport;mitochondrial transport;organic acid transport;organic anion transport;transport;tricarboxylic acid transport 11 11 11 36.3 36.3 36.3 34.012 4.7495E-67 513800000 270840000 242960000 3834 IPI:IPI00294159.3 Tricarboxylate transport protein, mitochondrial;Citrate transport protein;Tricarboxylate carrier protein;Solute carrier family 25 member 1 SLC25A1;SLC20A3 P53007 ENST00000215882 K03454 1 0.75198 1.4751 0.77221 1.0647 0.95491 1.0065 HEAT antigen binding;binding;protein binding;protein dimerization activity;protein heterodimerization activity Long-term depression;TGF-beta signaling pathway;Tight junction;Wnt signaling pathway 21 15 15 43 30.4 30.4 73.584 0 403630000 209150000 194480000 3835 IPI:IPI00335449.3;IPI:IPI00294178.2 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform;PP2A, subunit A, PR65-beta isoform;PP2A, subunit A, R1-beta isoform PPP2R1B P30154-2;P30154;P30154-1 ENST00000311129;ENST00000341980 K03456 2 0.86008 1.3656 0.74746 1.1089 0.94324 0.97558 Beta-lactamase cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle catalytic activity;hydrolase activity 7 7 7 15 15 15 60.693 6.2345E-106 49040000 26060000 22980000 3836 IPI:IPI00294186.4;IPI:IPI00375490.5 Serine beta-lactamase-like protein LACTB, mitochondrial LACTB;MRPL56;UNQ843/PRO1781 P83111-1;P83111 ENST00000261893 2 0.48141 NaN 0.52377 0.6399 NaN 0.6981 DUF1605;HA2;Helicase_C cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex ATP binding;ATP-dependent helicase activity;ATP-dependent RNA helicase activity;binding;catalytic activity;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;RNA helicase activity nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 3 3 3 2.7 2.7 2.7 140.5 7.9743E-38 6301100 3347000 2954000 3837 IPI:IPI00294211.2 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16;ATP-dependent RNA helicase DHX38;DEAH box protein 38 DHX38;DDX38;KIAA0224;PRP16 Q92620 ENST00000268482 1 0.45888 0.95819 0.56548 0.57242 0.65924 0.7138 RTC;RTC_insert cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part catalytic activity;cyclase activity;ligase activity;ligase activity, forming phosphoric ester bonds;RNA-3'-phosphate cyclase activity cellular component biogenesis;cellular process;ribonucleoprotein complex biogenesis;ribosome biogenesis 6 6 6 20.4 20.4 20.4 40.842 4.714E-92 112200000 61341000 50863000 3838 IPI:IPI00294229.6 RNA 3'-terminal phosphate cyclase-like protein RCL1;RNAC;RPC2;RPCL1;RTC2;HSPC338 Q9Y2P8 ENST00000381750 K11108 1 0.77495 1.4777 0.62378 1.1485 0.88431 0.99338 zf-C2H2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;RNA binding;RNA polymerase III transcription factor activity;transcription regulator activity;transition metal ion binding;zinc ion binding nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription;transcription from RNA polymerase III promoter;transcription, DNA-dependent 5 5 5 17 17 17 41.514 2.8634E-10 61348000 33517000 27831000 3839 IPI:IPI00294241.3;IPI:IPI00885034.1 Transcription factor IIIA GTF3A Q92664-1;Q92664;Q92664-2 ENST00000381140 2 0.77173 1.385 0.75921 1.0014 0.97886 0.97845 intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;mitochondrion;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome binding;protein binding;protein domain specific binding 9 9 9 26.8 26.8 26.8 45.318 6.7885E-80 172470000 91931000 80541000 3840 IPI:IPI00294242.2 28S ribosomal protein S31, mitochondrial;MRP-S31;Imogen 38 MRPS31;IMOGN38 Q92665 ENST00000323563 1 0.80834 1.6211 0.86826 1.0284 1.0945 1.0792 PEPCK cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle binding;carbon-carbon lyase activity;carboxy-lyase activity;catalytic activity;GTP binding;lyase activity;nucleotide binding;phosphoenolpyruvate carboxykinase (GTP) activity;phosphoenolpyruvate carboxykinase activity;purine nucleotide binding alcohol metabolic process;biosynthetic process;carbohydrate metabolic process;cellular process;gluconeogenesis;glucose metabolic process;metabolic process;monosaccharide metabolic process;organic acid metabolic process;pyruvate metabolic process 21 21 21 40.3 40.3 40.3 70.636 3.5183E-273 277790000 147890000 129900000 3841 IPI:IPI00294380.5;IPI:IPI00292709.2 Phosphoenolpyruvate carboxykinase [GTP], mitochondrial;Phosphoenolpyruvate carboxylase PCK2;PEPCK2 Q16822 ENST00000216780 2 0.68427 1.5481 0.7922 0.93443 1.0513 1.0142 3HCDH;3HCDH_N cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part 3-hydroxyacyl-CoA dehydrogenase activity;binding;catalytic activity;cofactor binding;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor carboxylic acid metabolic process;cellular ketone metabolic process;cellular process;fatty acid metabolic process;lipid metabolic process;metabolic process;monocarboxylic acid metabolic process;organic acid metabolic process;oxoacid metabolic process Butanoate metabolism;Caprolactam degradation;Fatty acid elongation in mitochondria;Fatty acid metabolism;Geraniol degradation;Lysine degradation;Tryptophan metabolism;Valine, leucine and isoleucine degradation 11 11 11 59.2 59.2 59.2 34.277 3.4014E-221 357120000 201280000 155840000 3843 IPI:IPI00294398.1;IPI:IPI00298406.3 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial;Short chain 3-hydroxyacyl-CoA dehydrogenase;Medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase HADH;HAD;HADHSC;SCHAD Q16836-1;Q16836;Q16836-2 ENST00000309522;ENST00000351726 K00022 2 0.50125 1.1314 0.38073 0.67378 0.70245 0.55168 ORC3_N cell part;chromosomal part;intracellular organelle part;intracellular part;macromolecular complex;nuclear chromosome part;nuclear origin of replication recognition complex;nuclear part;nucleoplasm;organelle part;origin recognition complex;protein complex binding;DNA binding;DNA replication origin binding;nucleic acid binding;protein binding;sequence-specific DNA binding biosynthetic process;cellular process;DNA metabolic process;DNA replication;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Cell cycle;Cell cycle - yeast 9 9 9 15.6 15.6 15.6 82.324 1.9311E-150 60223000 33889000 26334000 3844 IPI:IPI00374747.5;IPI:IPI00294402.1 Origin recognition complex subunit 3;Origin recognition complex subunit Latheo ORC3L;LATHEO Q9UBD5-2;Q9UBD5;Q9UBD5-1 ENST00000257789;ENST00000392844 K02605 2 0.75844 2.3032 0.744 1.0109 1.3886 1.0018 EMP24_GP25L cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;ER-Golgi intermediate compartment;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part establishment of localization;transport 3 3 3 17.5 17.5 17.5 26.005 7.2175E-07 55660000 30360000 25300000 3845 IPI:IPI00294472.3 Transmembrane emp24 domain-containing protein 5 TMED5;CGI-100;UNQ397/PRO733 Q9Y3A6 ENST00000370290 1 0.75084 1.822 0.80679 1.026 1.1587 1.0897 UFC1 binding;protein binding catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 7 7 7 34.7 34.7 34.7 19.458 4.7901E-16 726530000 383990000 342540000 3846 IPI:IPI00294495.5 Ufm1-conjugating enzyme 1;Ubiquitin-fold modifier-conjugating enzyme 1 UFC1;CGI-126;HSPC155 Q9Y3C8 ENST00000368003 K12165 1 0.70303 1.2166 0.71615 0.86699 0.86661 0.90271 ERG4_ERG24 endoplasmic reticulum membrane;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;nuclear membrane;nuclear outer membrane;nuclear part;organelle membrane;organelle outer membrane;organelle part;outer membrane 7-dehydrocholesterol reductase activity;binding;catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on the CH-CH group of donors;oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor;protein binding alcohol metabolic process;biosynthetic process;cellular process;cholesterol biosynthetic process;cholesterol metabolic process;lipid biosynthetic process;lipid metabolic process;metabolic process;steroid biosynthetic process;steroid metabolic process Biosynthesis of steroids 7 7 7 16 16 16 54.489 2.4078E-276 784290000 410690000 373600000 3847 IPI:IPI00294501.1 7-dehydrocholesterol reductase;Sterol Delta(7)-reductase;Putative sterol reductase SR-2 DHCR7;D7SR Q9UBM7 ENST00000355527;ENST00000407721 K00213 1 0.79572 1.5233 0.84831 1.0605 1.0497 1.0938 F-box cell part;intracellular part;macromolecular complex;protein complex;ubiquitin ligase complex acid-amino acid ligase activity;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;protein binding;small conjugating protein ligase activity;ubiquitin-protein ligase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;posttranscriptional regulation of gene expression;proteolysis;regulation of gene expression;regulation of metabolic process;ubiquitin-dependent protein catabolic process 10 10 10 24.1 24.1 24.1 58.502 1.1247E-150 60294000 32142000 28152000 3848 IPI:IPI00294567.3 F-box only protein 7 FBXO7;FBX7 Q9Y3I1 ENST00000266087;ENST00000382058 K10293 1 0.64779 1.224 0.62175 0.88039 0.80682 0.82979 TPR_1 centrosome;cytosol;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;microtubule;microtubule organizing center;non-membrane-bounded organelle;nuclear part;nucleoplasm;organelle;organelle part;spindle microtubule binding;protein binding catabolic process;cell proliferation;cellular process;macromolecule catabolic process;metabolic process;mitotic metaphase/anaphase transition;proteasomal protein catabolic process;proteolysis;ubiquitin-dependent protein catabolic process Cell cycle;Cell cycle - yeast;Progesterone-mediated oocyte maturation;Ubiquitin mediated proteolysis 9 9 9 10.8 10.8 10.8 91.866 1.5318E-141 93366000 49760000 43606000 3849 IPI:IPI00294575.7 Cell division cycle protein 27 homolog;H-NUC CDC27;D0S1430E;D17S978E P30260 ENST00000066544 K03350 1 0.32232 0.54872 NaN 0.44832 0.37887 NaN zf-FCS cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 10 10 10 8 8 8 155.15 1.8821E-49 6478300 4006000 2472300 3850 IPI:IPI00294603.6 Zinc finger MYM-type protein 2;Zinc finger protein 198;Fused in myeloproliferative disorders protein;Rearranged in atypical myeloproliferative disorder protein ZMYM2;FIM;RAMP;ZNF198 Q9UBW7 ENST00000382869;ENST00000382883 1 0.76338 1.1492 NaN 1.0221 0.76163 NaN PRCC_Cterm 4 4 4 12.4 12.4 12.4 52.417 6.1057E-131 9549500 4230000 5319600 3851 IPI:IPI00294618.1 Proline-rich protein PRCC;Papillary renal cell carcinoma translocation-associated gene protein PRCC;TPRC Q92733 ENST00000271526 1 1.0409 1.8195 1.0786 1.2291 1.205 1.3935 PB1 cell part;cytoplasm;intracellular part molecular transducer activity;signal transducer activity positive regulation of cell communication;positive regulation of protein kinase cascade;positive regulation of signal transduction;regulation of cell communication;regulation of protein kinase cascade;regulation of signal transduction 7 7 7 19.5 19.5 19.5 43.447 5.6476E-50 280650000 145360000 135290000 3852 IPI:IPI00294619.2;IPI:REV_IPI00216719.1;IPI:REV_IPI00374976.1;IPI:REV_IPI00171230.6;IPI:REV_IPI00472614.3;IPI:REV_IPI00181684.5;IPI:REV_IPI00216720.3 Protein TFG;TRK-fused gene protein TFG Q92734 ENST00000240851;ENST00000406587 7 0.83861 1.5364 0.77033 1.0682 1.0309 1.0529 KH_1;zf-CCHC cytoplasmic part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;organelle;organelle part;ribonucleoprotein complex;ribosome;spliceosomal complex binding;nucleic acid binding;protein binding;RNA binding;RNA polymerase II transcription factor activity;transcription cofactor activity;transcription corepressor activity;transcription factor binding;transcription repressor activity;zinc ion binding metabolic process;mRNA splice site selection;nitrogen compound metabolic process;nuclear mRNA 3'-splice site recognition;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 9 9 1 24.1 24.1 2.3 68.329 1.3519E-141 815080000 576710000 238370000 3853 IPI:IPI00386114.1;IPI:IPI00294627.3;IPI:IPI00386117.3;IPI:IPI00386120.3;IPI:IPI00386118.3 Splicing factor 1;Zinc finger protein 162;Transcription factor ZFM1;Zinc finger gene in MEN1 locus;Mammalian branch point-binding protein mBBP SF1;ZFM1;ZNF162 Q15637-1;Q15637;Q15637-2;Q15637-3;Q15637-6;Q15637-4 ENST00000227503;ENST00000334944;ENST00000377387;ENST00000377390 5 NaN 2.1794 1.2107 NaN 1.3493 1.6643 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding 3 3 3 13.9 13.9 13.9 35.438 3.9987E-15 22032000 11488000 10544000 3854 IPI:IPI00294680.5 Putative TRAF4-associated factor 1 TRAF4AF1;C15orf23;HSD11 Q9Y448 ENST00000249776 1 0.89349 NaN 0.94086 1.2605 NaN 1.1468 TFIIS cell part;intracellular organelle part;intracellular part;macromolecular complex;mediator complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;DNA binding;nucleic acid binding;protein binding;RNA polymerase II transcription factor activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding cellular process;regulation of biosynthetic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription initiation;transcription initiation from RNA polymerase II promoter 4 4 4 12.2 12.2 12.2 65.446 3.3184E-45 5964600 2800900 3163700 3855 IPI:IPI00294682.2;IPI:IPI00827801.1 Mediator of RNA polymerase II transcription subunit 26;Mediator complex subunit 26;Cofactor required for Sp1 transcriptional activation subunit 7;CRSP complex subunit 7;Transcriptional coactivator CRSP70;Activator-recruited cofactor 70 kDa component MED26;ARC70;CRSP7 O95402-1;O95402 ENST00000263390 2 0.42159 0.90955 0.40343 0.55223 0.55887 0.49545 MAT1;zf-C3HC4 cell part;cytoplasm;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;cation binding;ion binding;metal ion binding;protein binding;protein N-terminus binding;transition metal ion binding;zinc ion binding DNA catabolic process;DNA metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleotide-excision repair, DNA damage removal;regulation of cyclin-dependent protein kinase activity;RNA elongation;transcription initiation Nucleotide excision repair 3 3 3 16.8 16.8 16.8 35.823 4.2838E-34 30807000 17951000 12856000 3856 IPI:IPI00294701.1 CDK-activating kinase assembly factor MAT1;RING finger protein MAT1;Menage a trois;CDK7/cyclin H assembly factor;p36;p35;Cyclin G1-interacting protein;RING finger protein 66 MNAT1;CAP35;MAT1;RNF66 P51948 ENST00000261245 K10842 1 0.86095 1.6933 0.76782 1.1669 1.0839 1.0544 La;RRM_1;RRM_3 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;ribonucleoprotein complex binding;nucleic acid binding;nucleotide binding;RNA binding cellular biopolymer metabolic process;cellular process;macromolecule metabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing 14 14 14 25.8 25.8 25.8 67.653 1.3013E-74 250470000 129220000 121250000 3857 IPI:IPI00294742.6;IPI:IPI00395536.3 La-related protein 7;La ribonucleoprotein domain family member 7;P-TEFb-interaction protein for 7SK stability LARP7;HDCMA18P Q4G0J3-1;Q4G0J3 ENST00000308878;ENST00000324052;ENST00000344442 2 0.69932 1.2 0.62306 0.93935 0.78914 0.81294 CAF1;R3H;RNA_bind cell part;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part catalytic activity;exonuclease activity;exoribonuclease activity;magnesium ion binding;mRNA 3'-UTR binding;mRNA binding;nuclease activity;nucleic acid binding;nucleotide binding;poly(A)-specific ribonuclease activity;ribonuclease activity;RNA binding mRNA catabolic process;nuclear-transcribed mRNA catabolic process;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA catabolic process 9 9 9 15 15 15 73.45 5.1708E-34 91795000 48706000 43090000 3858 IPI:IPI00294744.7 Poly(A)-specific ribonuclease PARN;Polyadenylate-specific ribonuclease;Deadenylating nuclease;Deadenylation nuclease PARN;DAN O95453 ENST00000341484 1 0.62751 1.1576 0.48738 0.86984 0.71331 0.67535 Crystall;Ricin_B_lectin binding;carbohydrate binding;sugar binding 6 6 6 5.3 5.3 5.3 188.67 1.3301E-72 33535000 19332000 14203000 3860 IPI:IPI00294840.6 Absent in melanoma 1 protein;Beta/gamma crystallin domain-containing protein 1 AIM1;CRYBG1 Q9Y4K1 ENST00000369066 1 0.28825 0.66392 NaN 0.39687 0.4391 NaN CNH;Pkinase cell part;cytoplasm;intracellular part ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;small GTPase regulator activity;transferase activity activation of JUN kinase activity;activation of MAPK activity;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;regulation of protein amino acid phosphorylation 3 3 3 3.8 3.8 3.8 95.039 1.5381E-05 4802900 2740500 2062400 3861 IPI:IPI00294842.3 Mitogen-activated protein kinase kinase kinase kinase 5;MAPK/ERK kinase kinase kinase 5;Kinase homologous to SPS1/STE20 MAP4K5 Q9Y4K4 ENST00000013125 K08833 1 0.63076 1.3475 0.67559 0.82992 0.87975 0.89729 RanGAP1_C cell fraction;condensed chromosome kinetochore;intracellular organelle;kinetochore;macromolecular complex;membrane;non-membrane-bounded organelle;nuclear membrane;nuclear pore;organelle;organelle membrane;soluble fraction binding;enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;protein binding;Ran GTPase activator activity;Ras GTPase activator activity;small GTPase regulator activity biological regulation;cell communication;cellular process;regulation of biological process;regulation of cellular process;signal transduction 21 21 21 39.9 39.9 39.9 63.541 0 1380500000 750980000 629540000 3862 IPI:IPI00294879.1 Ran GTPase-activating protein 1 RANGAP1;KIAA1835;SD P46060 ENST00000356244;ENST00000405383;ENST00000405486;ENST00000407260 1 0.78502 2.6713 NaN 0.94018 1.9438 NaN PMM cell part;cytoplasm;intracellular part catalytic activity;intramolecular transferase activity;intramolecular transferase activity, phosphotransferases;isomerase activity;phosphomannomutase activity alcohol metabolic process;biosynthetic process;carbohydrate biosynthetic process;carbohydrate metabolic process;hexose metabolic process;mannose biosynthetic process;mannose metabolic process;metabolic process;monosaccharide metabolic process Fructose and mannose metabolism 3 2 2 11.8 9.2 9.2 29.746 2.5197E-16 15407000 14649000 757980 3863 IPI:IPI00294903.3 Phosphomannomutase 1;PMMH-22 PMM1;PMMH22 Q92871 ENST00000216259 K01840 1 0.84348 1.3404 0.90915 1.0808 0.93201 1.172 Fer2 cell part;cytoplasmic part;intracellular organelle part;intracellular part;membrane;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part binding;catalytic activity;electron carrier activity;iron ion binding;oxidoreductase activity;oxidoreductase activity, acting on the CH-CH group of donors;protein binding;succinate dehydrogenase (ubiquinone) activity acetyl-CoA metabolic process;catabolic process;cellular process;coenzyme catabolic process;coenzyme metabolic process;electron transport chain;generation of precursor metabolites and energy;metabolic process;transport;tricarboxylic acid cycle Alzheimer's disease;Citrate cycle (TCA cycle);Huntington's disease;Oxidative phosphorylation;Parkinson's disease 10 10 10 37.5 37.5 37.5 31.629 1.4299E-68 551050000 283620000 267430000 3864 IPI:IPI00294911.1 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial;Iron-sulfur subunit of complex II SDHB;SDH;SDH1 P21912 ENST00000375499 K00235 1 0.86255 1.6406 0.90733 1.1637 1.0813 1.2012 IBR cell part;cytoplasm;intracellular part;macromolecular complex;protein complex;ubiquitin ligase complex acid-amino acid ligase activity;binding;catalytic activity;cation binding;ion binding;ligase activity;ligase activity, forming carbon-nitrogen bonds;metal ion binding;protein binding;small conjugating protein ligase activity;zinc ion binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process 11 11 11 23.9 23.9 23.9 64.117 3.1969E-116 267160000 137670000 129490000 3865 IPI:IPI00294943.1 Protein ariadne-1 homolog;Ubiquitin-conjugating enzyme E2-binding protein 1;UbcH7-binding protein;UbcM4-interacting protein;HHARI;H7-AP2;Monocyte protein 6 ARIH1;ARI;MOP6;UBCH7BP;HUSSY-27 Q9Y4X5 ENST00000379887 K11968 1 0.75807 1.5912 0.79841 1.0312 1.0087 1.0211 LSM cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;small nuclear ribonucleoprotein complex;U6 snRNP binding;nucleic acid binding;protein binding;RNA binding cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 8 8 8 48.2 48.2 48.2 15.35 9.9918E-85 708480000 381560000 326910000 3866 IPI:IPI00294955.3 U6 snRNA-associated Sm-like protein LSm4;Glycine-rich protein LSM4 Q9Y4Z0 ENST00000252816 1 0.98067 1.876 0.91208 1.4242 1.1268 1.2694 SH3_1 adherens junction;cell fraction;cell junction;cell-substrate adherens junction;cell-substrate junction;cytoplasmic vesicle membrane;cytoskeleton;cytosol;focal adhesion;insoluble fraction;membrane;membrane fraction;nucleus;synaptosome;vesicle membrane binding;protein binding;protein domain specific binding;SH3 domain binding apoptosis;cell communication;cell death;cell-cell signaling;cellular component organization;cellular process;death;endocytosis;membrane invagination;membrane organization;programmed cell death;transport;vesicle-mediated transport 11 11 11 19.4 19.4 19.4 73.125 3.5398E-75 125890000 71064000 54826000 3867 IPI:IPI00294962.4;IPI:IPI00477897.1 SH3 domain-containing kinase-binding protein 1;Cbl-interacting protein of 85 kDa;Human Src family kinase-binding protein 1;CD2-binding protein 3 SH3KBP1;CIN85 Q96B97-1;Q96B97;Q96B97-2 ENST00000379698;ENST00000379726;ENST00000397821 2 NaN 1.2437 0.74642 NaN 0.82103 0.90316 NDK ATP binding;binding;catalytic activity;kinase activity;magnesium ion binding;nucleoside binding;nucleoside diphosphate kinase activity;nucleotide binding;purine nucleoside binding;transferase activity GTP biosynthetic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;pyrimidine nucleoside metabolic process;pyrimidine nucleotide metabolic process Purine metabolism;Pyrimidine metabolism 3 3 3 10.6 10.6 10.6 42.491 3.7623E-13 29093000 15016000 14077000 3868 IPI:IPI00294997.3 Nucleoside diphosphate kinase 7;nm23-H7 NME7 Q9Y5B8 ENST00000367811 K00940 1 0.75745 1.6006 0.77338 1.012 1.0312 1.0279 Ribosomal_S10 intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;mitochondrion;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 7 7 7 36.3 36.3 36.3 23.934 3.4677E-68 106580000 57740000 48837000 3870 IPI:IPI00295066.4 39S ribosomal protein L48, mitochondrial MRPL48;CGI-118;HSPC290 Q96GC5 ENST00000310614;ENST00000398483 1 0.58509 1.1068 0.5736 0.7632 0.74493 0.71913 Tubulin;Tubulin_C chromosome;condensed chromosome;condensed nuclear chromosome;gamma-tubulin complex;macromolecular complex;microtubule;microtubule organizing center;nuclear chromosome;organelle;polar microtubule;spindle microtubule;spindle pole body binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity;structural constituent of cytoskeleton;structural molecule activity anatomical structure formation;cellular process;cytoskeleton organization;meiotic spindle organization;microtubule cytoskeleton organization;microtubule-based process;organelle organization;protein complex assembly;spindle organization 12 12 12 41.9 41.9 41.9 51.169 5.7859E-82 278380000 156620000 121760000 3871 IPI:IPI00295081.1;IPI:IPI00299830.3 Tubulin gamma-1 chain;Gamma-1-tubulin;Gamma-tubulin complex component 1;Tubulin gamma-2 chain;Gamma-2-tubulin TUBG1;TUBG;TUBG2 P23258;Q9NRH3 ENST00000251413;ENST00000251412 K10389 2 0.65453 1.4556 0.6978 0.89678 0.93364 0.89539 SRPRB cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular part;intrinsic to membrane;macromolecular complex;membrane;membrane part;organelle membrane;organelle part;ribonucleoprotein complex binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;protein binding;purine nucleotide binding;purine ribonucleotide binding;receptor activity;ribonucleotide binding;signal transducer activity 16 16 16 64.6 64.6 64.6 29.702 7.6354E-260 421040000 227380000 193650000 3872 IPI:IPI00295098.3 Signal recognition particle receptor subunit beta;Protein APMCF1 SRPRB;PSEC0230 Q9Y5M8 ENST00000273406 K12272 1 0.83551 1.9209 0.95651 1.1526 1.2035 1.2015 PX;Vps5 binding;lipid binding;phosphoinositide binding;phospholipid binding;protein binding cell communication;cellular process;establishment of localization;establishment of protein localization;protein transport;transport 15 14 14 42.3 42.3 42.3 46.816 9.1781E-191 518780000 278510000 240270000 3873 IPI:IPI00295209.5;IPI:REV_IPI00328555.3 Sorting nexin-5 SNX5 Q9Y5X3 ENST00000377759;ENST00000377768 2 0.77182 1.3332 0.77557 0.97387 0.91929 0.96048 Aminotran_5 cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;mitochondrial matrix;mitochondrial part;nucleus;organelle;organelle part binding;catalytic activity;cysteine desulfurase activity;lipid binding;protein binding;pyridoxal phosphate binding;steroid binding;sulfurtransferase activity;transferase activity;transferase activity, transferring sulfur-containing groups;vitamin binding cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;cysteine metabolic process;organic acid metabolic process;protein complex assembly;protein modification process;sulfur amino acid metabolic process Thiamine metabolism 9 9 9 26.7 26.7 26.7 50.195 6.7009E-187 232920000 122870000 110040000 3874 IPI:IPI00295240.6;IPI:IPI00643101.1 Cysteine desulfurase, mitochondrial NFS1;NIFS;HUSSY-08 Q9Y697-1;Q9Y697;Q9Y697-2 ENST00000374092 K04487 2 0.74682 1.3067 0.77698 0.92448 0.82073 0.96536 fn3 cell part;cytoplasm;intracellular part;membrane;plasma membrane 7 7 7 22.9 22.9 22.9 49.765 2.0763E-98 188240000 99512000 88725000 3875 IPI:IPI00295387.5 Cytokine receptor-like factor 3;Cytokine receptor-related protein 4;Cytokine receptor-like molecule 9;Type I cytokine receptor-like factor p48 CRLF3;CREME9;CYTOR4;P48 Q8IUI8 ENST00000324238 1 0.74882 1.3325 1.8775 0.99598 0.84742 2.5289 CtaG_Cox11 cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part binding;catalytic activity;cation transmembrane transporter activity;copper ion binding;cytochrome-c oxidase activity;electron carrier activity;heme-copper terminal oxidase activity;ion transmembrane transporter activity;transporter activity anatomical structure formation;cellular component assembly;cellular component organization;cellular process;multicellular organismal process;protein complex assembly;respiratory chain complex IV assembly;respiratory gaseous exchange Oxidative phosphorylation 5 5 5 23.6 23.6 23.6 31.43 3.5539E-75 11552000 4532400 7019500 3876 IPI:IPI00295394.2 Cytochrome c oxidase assembly protein COX11, mitochondrial COX11 Q9Y6N1 ENST00000299335;ENST00000393171 K02258 1 0.99259 1.9758 1.0244 1.2904 1.2401 1.3233 tRNA-synt_1b;WHEP-TRS cell fraction;cell part;cytoplasm;intracellular part;soluble fraction aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-oxygen bonds;nucleoside binding;nucleotide binding;purine nucleoside binding;tryptophan-tRNA ligase activity cellular amino acid and derivative metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;tRNA aminoacylation for protein translation;tRNA metabolic process;tryptophanyl-tRNA aminoacylation Aminoacyl-tRNA biosynthesis;Tryptophan metabolism 19 19 19 50.5 50.5 50.5 53.165 0 583840000 297010000 286840000 3877 IPI:IPI00295400.1;IPI:IPI00412737.1 Tryptophanyl-tRNA synthetase, cytoplasmic;Tryptophan--tRNA ligase;Interferon-induced protein 53 WARS;IFI53;WRS P23381-1;P23381;P23381-2 ENST00000355338;ENST00000392880;ENST00000392882 K01867 2 1.1959 2.1221 1.1543 1.5095 1.3853 1.4965 HSP70 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cellular biopolymer metabolic process;cellular process;metabolic process;protein folding;protein metabolic process;response to biotic stimulus;response to chemical stimulus;response to organic substance;response to stress;response to unfolded protein 35 31 31 48.4 45.4 45.4 94.485 0 2020400000 1001100000 1019300000 3878 IPI:IPI00295485.1 Heat shock 70 kDa protein 4L;Osmotic stress protein 94;Heat shock 70-related protein APG-1 HSPA4L;APG1;OSP94 O95757 ENST00000296464 K09485 1 0.77931 1.5282 NaN 1.0093 1.0385 NaN CAF1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;protein binding;transcription factor activity;transcription regulator activity biosynthetic process;metabolic process;negative regulation of cell proliferation;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 4 3 3 15.8 13.4 13.4 33.54 2.2506E-10 13202000 7876600 5325400 3879 IPI:IPI00295501.1 CCR4-NOT transcription complex subunit 8;CCR4-associated factor 8;CAF1-like protein;CALIFp;CAF2 CNOT8;CALIF;POP2 Q9UFF9 ENST00000285896;ENST00000403027 1 0.5936 1.2632 0.52363 0.79348 0.79463 0.70458 zf-C2H2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding 2 2 2 2.2 2.2 2.2 178.67 1.7321E-06 12224000 6678900 5545500 3880 IPI:IPI00295502.6;IPI:IPI00922835.2 Protein Wiz;Widely-interspaced zinc finger-containing protein;Zinc finger protein 803 WIZ;ZNF803 O95785-1;O95785;O95785-2 ENST00000263381;ENST00000389282 2 3.1977 3.6085 3.005 4.297 2.3083 3.806 cytoskeleton;ER-Golgi intermediate compartment;extracellular space;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;membrane;membrane-bounded organelle;non-membrane-bounded organelle;organelle binding;calcium ion binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding 5 5 5 12.6 12.6 12.6 53.879 1.5586E-23 13689000 3913800 9775000 3881 IPI:IPI00295542.5 Nucleobindin-1;CALNUC NUCB1;NUC Q02818 ENST00000263273;ENST00000405315;ENST00000407032 1 0.79013 1.4562 0.74228 1.0772 0.9205 1.0136 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;double-stranded DNA binding;nucleic acid binding;structure-specific DNA binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 6 6 6 42.5 42.5 42.5 18.82 9.3222E-51 53542000 25493000 28048000 3882 IPI:IPI00295585.2 CGG triplet repeat-binding protein 1;p20-CGGBP DNA-binding protein;20 kDa CGG-binding protein CGGBP1;CGGBP Q9UFW8 ENST00000309534;ENST00000398392 1 0.76836 1.7541 0.80334 0.98824 1.1513 0.96994 centriole;cytoplasmic part;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;microtubule organizing center part;non-membrane-bounded organelle;organelle;organelle part binding;protein binding;protein domain specific binding cell cycle process;cell division;cellular component organization;cellular process;centriole replication;centrosome organization;centrosome separation;cytokinesis;microtubule organizing center organization;microtubule-based process;organelle organization 2 2 2 3.4 3.4 3.4 103.81 9.434E-13 66286000 33242000 33043000 3883 IPI:IPI00385978.2;IPI:IPI00658082.1;IPI:IPI00295638.3;IPI:IPI00657639.1 Centrobin;Centrosomal BRCA2-interacting protein;LYST-interacting protein 8 CNTROB;LIP8;PP1221 Q8N137-2;Q8N137;Q8N137-3;Q8N137-1;Q8N137-5 ENST00000303707;ENST00000380255;ENST00000380262 4 0.88844 2.1418 0.98605 1.2059 1.2495 1.394 Peptidase_C1;Propeptide_C1 cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;lysosome;lytic vacuole;melanosome;membrane-bounded organelle;membrane-bounded vesicle;organelle;vacuole;vesicle catalytic activity;cysteine-type endopeptidase activity;cysteine-type peptidase activity;endopeptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;protein catabolic process;protein metabolic process;proteolysis;regulation of apoptosis;regulation of cell death;regulation of programmed cell death Antigen processing and presentation 9 9 9 31.6 31.6 31.6 37.821 1.2607E-76 75203000 36239000 38964000 3884 IPI:IPI00295741.4 Cathepsin B;Cathepsin B1;APP secretase;Cathepsin B light chain;Cathepsin B heavy chain CTSB;CPSB P07858 ENST00000345125;ENST00000353047 K01363 1 0.79579 1.936 0.82543 1.1524 1.182 1.1779 Prenyltrans binding;catalytic activity;prenyltransferase activity;protein binding;protein geranylgeranyltransferase activity;protein prenyltransferase activity;Rab geranylgeranyltransferase activity;transferase activity;zinc ion binding cellular biopolymer metabolic process;cellular process;macromolecule metabolic process;metabolic process;multicellular organismal process;protein metabolic process;protein modification process;sensory perception;system process;visual perception 3 3 3 9.7 9.7 9.7 36.924 1.2588E-11 75884000 42918000 32967000 3886 IPI:IPI00295849.3 Geranylgeranyl transferase type-2 subunit beta;Geranylgeranyl transferase type II subunit beta;Type II protein geranyl-geranyltransferase subunit beta;Rab geranylgeranyltransferase subunit beta;Rab geranyl-geranyltransferase subunit beta RABGGTB;GGTB P53611 ENST00000319942 K05956 1 0.88642 1.7541 0.88206 1.1348 1.1509 1.2004 Adaptin_N;Coatamer_beta_C cell part;COPI vesicle coat;cytoplasmic part;cytoplasmic vesicle part;cytosol;Golgi apparatus part;intracellular organelle part;intracellular part;macromolecular complex;membrane coat;membrane part;organelle part;protein complex;vesicle coat binding;protein binding;structural molecule activity cellular component organization;cellular process;intracellular protein transport;intra-Golgi vesicle-mediated transport;organelle organization;protein transport;retrograde vesicle-mediated transport, Golgi to ER;transport;vesicle coating 34 34 34 41.1 41.1 41.1 107.14 0 1265900000 666280000 599650000 3887 IPI:IPI00295851.4 Coatomer subunit beta;Beta-coat protein COPB1;COPB;MSTP026 P53618 ENST00000249923 1 0.68423 1.2865 0.68427 0.87264 0.86067 0.90707 Coatomer_WDAD;COPI_C;WD40 cell fraction;COPI vesicle coat;cytosol;endoplasmic reticulum;extracellular space;insoluble fraction;macromolecular complex;membrane coat;membrane fraction;membrane-bounded organelle;microsome;organelle;soluble fraction;vesicle coat;vesicular fraction binding;calcium ion binding;cation binding;hormone activity;ion binding;metal ion binding;protein binding;receptor binding;structural molecule activity;unfolded protein binding body fluid secretion;cellular process;intracellular protein transport;metabolic process;organelle organization;protein folding;protein transport;retrograde vesicle-mediated transport, Golgi to ER;system process;transport;vesicle coating Neuroactive ligand-receptor interaction 46 46 46 45.2 45.2 45.2 139.32 0 3209400000 1713200000 1496200000 3888 IPI:IPI00646493.1;IPI:IPI00295857.7 Coatomer subunit alpha;Alpha-coat protein;HEP-COP;Xenin;Xenopsin-related peptide;Proxenin COPA P53621-2;P53621;P53621-1 ENST00000241704;ENST00000368069 K05236 2 0.82376 2.0238 0.71686 1.1707 1.2827 0.98432 SRP19 intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nucleolus;organelle;organelle part;ribonucleoprotein complex;signal recognition particle, endoplasmic reticulum targeting 7S RNA binding;binding;nucleic acid binding;RNA binding cotranslational protein targeting to membrane;intracellular protein transport;protein targeting;protein targeting to ER;protein targeting to membrane;protein transport;SRP-dependent cotranslational protein targeting to membrane;transport Protein export 7 7 7 56.2 56.2 56.2 16.156 1.8974E-49 148500000 78268000 70235000 3889 IPI:IPI00295889.2 Signal recognition particle 19 kDa protein SRP19 P09132 ENST00000282999 K03105 1 0.6367 1.3703 0.64421 0.85365 0.89795 0.85138 AAA ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity 23 23 8 31.1 31.1 13.7 66.217 1.4438E-158 1317300000 723950000 593370000 3891 IPI:IPI00295992.4;IPI:IPI00643435.1;IPI:IPI00443780.2 ATPase family AAA domain-containing protein 3A ATAD3A Q9NVI7-2;Q9NVI7;Q9NVI7-1 ENST00000378755 3 0.7681 1.3536 0.75473 0.90429 0.96746 0.96949 UCR_hinge cell part;cytoplasmic part;intracellular organelle part;intracellular part;membrane part;mitochondrial membrane part;mitochondrial part;mitochondrial respiratory chain;organelle part;respiratory chain catalytic activity;cation transmembrane transporter activity;ion transmembrane transporter activity;monovalent inorganic cation transmembrane transporter activity;transporter activity;ubiquinol-cytochrome-c reductase activity aerobic respiration;cellular process;electron transport chain;energy derivation by oxidation of organic compounds;generation of precursor metabolites and energy;metabolic process;mitochondrial electron transport, ubiquinol to cytochrome c;transport Alzheimer's disease;Cardiac muscle contraction;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 2 2 2 29.7 29.7 29.7 10.739 1.0432E-65 275000000 142670000 132330000 3892 IPI:IPI00296022.1 Cytochrome b-c1 complex subunit 6, mitochondrial;Ubiquinol-cytochrome c reductase complex 11 kDa protein;Cytochrome c1 non-heme 11 kDa protein;Mitochondrial hinge protein;Complex III subunit VIII;Complex III subunit 6 UQCRH P07919 ENST00000311672 K00416 1 0.76263 1.5126 0.79642 0.98725 1.0081 0.99961 FumaraseC_C;Lyase_1 cell part;cytoplasmic part;intracellular organelle part;intracellular part;macromolecular complex;mitochondrial matrix;mitochondrial part;organelle part;protein complex;tricarboxylic acid cycle enzyme complex carbon-oxygen lyase activity;catalytic activity;fumarate hydratase activity;hydro-lyase activity;lyase activity acetyl-CoA metabolic process;catabolic process;cell cycle;cellular process;coenzyme catabolic process;coenzyme metabolic process;fumarate metabolic process;metabolic process;organic acid metabolic process;tricarboxylic acid cycle Citrate cycle (TCA cycle);Pathways in cancer;Reductive carboxylate cycle (CO2 fixation);Renal cell carcinoma 17 17 17 48.2 48.2 48.2 54.636 0 2732500000 1342200000 1390300000 3893 IPI:IPI00296053.3;IPI:IPI00759715.1 Fumarate hydratase, mitochondrial FH P07954-1;P07954;P07954-2 ENST00000366560 K01679 2 NaN 0.47146 NaN NaN 0.33152 NaN DEAD;Helicase_C cell part;chromatoid body;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;ribonucleoprotein complex ATP binding;ATP-dependent helicase activity;ATP-dependent RNA helicase activity;binding;catalytic activity;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;RNA binding;RNA helicase activity cellular process;germ cell development;mRNA export from nucleus;multicellular organismal development;nucleocytoplasmic transport;regulation of biosynthetic process;regulation of translation;RNA export from nucleus;spermatid development;transport 2 1 1 4.8 2.5 2.5 54.691 1.6788E-11 749890 227820 522070 3894 IPI:IPI00296139.2 ATP-dependent RNA helicase DDX25;DEAD box protein 25;Gonadotropin-regulated testicular RNA helicase DDX25;GRTH Q9UHL0-1;Q9UHL0 ENST00000263576 1 0.85347 1.6334 0.95015 1.0494 1.0923 1.193 Peptidase_S28 cell part;cytoplasmic part;cytoplasmic vesicle;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;lysosome;lytic vacuole;membrane-bounded organelle;organelle;vacuole;vesicle aminopeptidase activity;binding;catalytic activity;exopeptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides;protein binding;serine hydrolase activity;serine-type peptidase activity biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis 7 7 7 16.9 16.9 16.9 54.341 1.6824E-147 53863000 27251000 26612000 3895 IPI:IPI00296141.4 Dipeptidyl-peptidase 2;Dipeptidyl-peptidase II;Dipeptidyl aminopeptidase II;Quiescent cell proline dipeptidase;Dipeptidyl peptidase 7 DPP7;DPP2;QPP Q9UHL4 ENST00000371579 K01276 1 NaN 0.84671 NaN NaN 0.61094 NaN FAD_binding_2 cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;intracellular part;membrane;membrane part;nuclear membrane;nuclear outer membrane;nuclear part;organelle membrane;organelle outer membrane;organelle part;outer membrane all-trans-retinol 13,14-reductase activity;catalytic activity;electron carrier activity;oxidoreductase activity;oxidoreductase activity, acting on the CH-CH group of donors cellular process;fat-soluble vitamin metabolic process;isoprenoid metabolic process;lipid metabolic process;metabolic process;retinoid metabolic process;terpenoid metabolic process;vitamin A metabolic process;vitamin metabolic process Retinol metabolism 5 5 5 11.8 11.8 11.8 66.819 5.0562E-51 9235600 4545100 4690400 3896 IPI:IPI00296157.6;IPI:IPI00335161.4 All-trans-retinol 13,14-reductase;All-trans-13,14-dihydroretinol saturase RETSAT;UNQ439/PRO872 Q6NUM9-1;Q6NUM9;Q6NUM9-2 ENST00000263854;ENST00000295802 K09516 2 0.66063 1.7297 0.7634 1.0379 1.0387 0.9943 cell part;cytoplasm;extracellular region;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part 10 10 10 37.6 37.6 37.6 25.764 1.687E-86 89411000 49662000 39749000 3897 IPI:IPI00296190.4 Uncharacterized protein C10orf58 C10orf58;PRO2290;PSEC0139;UNQ611/PRO1198 Q9BRX8 ENST00000372181;ENST00000372187;ENST00000372188;ENST00000394504 1 1.0406 1.7322 1.0119 1.367 1.1301 1.3512 V-ATPase_H cytosol;macromolecular complex;membrane;organelle part;plasma membrane;protein complex;proton-transporting two-sector ATPase complex, catalytic domain;proton-transporting V-type ATPase, V1 domain;vacuolar proton-transporting V-type ATPase, V1 domain binding;catalytic activity;cation transmembrane transporter activity;hydrogen ion transmembrane transporter activity;ion transmembrane transporter activity;monovalent inorganic cation transmembrane transporter activity;protein binding;transporter activity nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;purine nucleotide metabolic process;regulation of immune effector process;regulation of immune system process;regulation of response to biotic stimulus Epithelial cell signaling in Helicobacter pylori infection;Oxidative phosphorylation;Vibrio cholerae infection 17 17 17 38.5 38.5 38.5 55.882 2.0354E-105 433140000 194010000 239130000 3898 IPI:IPI00296191.1;IPI:IPI00414079.1 V-type proton ATPase subunit H;Vacuolar proton pump subunit H;V-ATPase 50/57 kDa subunits;Vacuolar proton pump subunit SFD;VMA13;Nef-binding protein 1 ATP6V1H;CGI-11 Q9UI12-1;Q9UI12;Q9UI12-2 ENST00000355221;ENST00000359530;ENST00000396774 K02144 2 0.78582 1.1755 1.0778 1.0552 0.83911 1.433 endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;membrane-enclosed lumen;organelle;organelle lumen;organelle part binding;protein binding;unfolded protein binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular process;intracellular protein transport;macromolecule metabolic process;metabolic process;protein folding;protein metabolic process;protein transport;transport 6 6 6 14.3 14.3 14.3 52.084 2.2854E-103 13079000 6694300 6384200 3899 IPI:IPI00296197.2 Nucleotide exchange factor SIL1;BiP-associated protein SIL1;UNQ545/PRO836 Q9H173 ENST00000265195;ENST00000394817 1 0.6212 NaN 0.32027 0.78278 NaN 0.42846 Dymeclin cell part;cytoplasmic part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle 3 3 3 4.8 4.8 4.8 75.935 2.0126E-10 9588600 5525600 4063000 3900 IPI:IPI00296211.6;IPI:IPI00921973.1 Dymeclin;Dyggve-Melchior-Clausen syndrome protein DYM Q7RTS9-1;Q7RTS9;Q7RTS9-2 ENST00000269445 2 0.68072 1.6157 1.015 0.86515 1.1564 1.4208 EMP24_GP25L cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part establishment of localization;transport 6 5 5 19.4 19.4 19.4 25.943 2.9371E-72 92362000 50243000 42119000 3901 IPI:IPI00296259.4;IPI:IPI00914891.1;IPI:IPI00914908.1 Transmembrane emp24 domain-containing protein 4;Endoplasmic reticulum stress-response protein 25;Putative NF-kappa-B-activating protein 156 TMED4;ERS25 Q7Z7H5-1;Q7Z7H5;Q7Z7H5-2;Q7Z7H5-3 ENST00000289577 3 0.48989 0.94727 0.48022 0.64436 0.63734 0.62276 FAT;FATC;HEAT;NUC194;PI3_PI4_kinase cell part;DNA-dependent protein kinase-DNA ligase 4 complex;intracellular organelle part;intracellular part;macromolecular complex;nonhomologous end joining complex;nuclear part;nucleoplasm;organelle part;protein complex ATP binding;binding;catalytic activity;DNA binding;DNA-dependent protein kinase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding DNA metabolic process;DNA recombination;DNA repair;double-strand break repair;double-strand break repair via nonhomologous end joining;non-recombinational repair;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Cell cycle;Non-homologous end-joining 155 155 155 39.4 39.4 39.4 469.08 0 7437000000 4004000000 3433100000 3902 IPI:IPI00296337.2;IPI:IPI00376215.2 DNA-dependent protein kinase catalytic subunit;DNPK1;p460 PRKDC;HYRC;HYRC1 P78527-1;P78527;P78527-2 ENST00000314191;ENST00000338368 K06642 2 0.63741 1.9348 0.5824 0.92445 1.1626 0.83571 Kinesin condensed chromosome kinetochore;intracellular membrane-bounded organelle;intracellular organelle;kinetochore;macromolecular complex;membrane-bounded organelle;microtubule;non-membrane-bounded organelle;nucleus;organelle;spindle ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;microtubule motor activity;motor activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity microtubule-based movement;microtubule-based process;mitotic chromosome movement towards spindle pole;mitotic metaphase;mitotic metaphase plate congression;multicellular organismal development;organelle organization;protein complex assembly 4 4 4 1.6 1.6 1.6 316.41 2.1247E-29 209240000 114550000 94689000 3903 IPI:IPI00296365.4;IPI:IPI00868715.1;IPI:IPI00619925.2 Centromere-associated protein E;Centromeric protein E CENPE Q02224-1;Q02224;Q02224-2;Q02224-3 ENST00000265148;ENST00000380026;ENST00000394771 K11498 3 0.82602 1.5705 0.93611 1.0173 1.1328 1.2629 cell part;cytoplasmic part;Golgi apparatus;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transition metal ion binding;zinc ion binding cellular process;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transport;vesicle-mediated transport 5 5 5 21.3 21.3 21.3 34.114 1.272E-13 64866000 36229000 28638000 3904 IPI:IPI00296374.3 Zinc finger protein-like 1;Zinc finger protein MCG4 ZFPL1 O95159 ENST00000294258 1 1.1084 1.8805 NaN 1.5118 1.2589 NaN AT_hook;Bromodomain;DDT;MBD;PHD cell part;chromosomal part;intracellular organelle part;intracellular part;macromolecular complex;nuclear chromosome part;nuclear part;nucleolar chromatin;nucleolar part;nucleolus organizer region;organelle part;protein complex binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transcription regulator activity;transition metal ion binding;zinc ion binding chromatin organization;chromatin remodeling;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;regulation of transcription, DNA-dependent;transcription 9 9 9 5 5 5 211.2 6.3321E-127 13745000 3760000 9985400 3905 IPI:IPI00296388.5;IPI:IPI00943770.1;IPI:IPI00759742.2 Bromodomain adjacent to zinc finger domain protein 2A;Transcription termination factor I-interacting protein 5 BAZ2A;KIAA0314;TIP5 Q9UIF9-1;Q9UIF9;Q9UIF9-3;Q9UIF9-2 ENST00000179765;ENST00000379441;ENST00000398156 3 0.80888 NaN NaN 1.1357 NaN NaN CH 2 2 2 2 2 2 161.85 0.0014916 9799200 5344700 4454600 3906 IPI:IPI00296421.2 EH domain-binding protein 1-like protein 1 EHBP1L1 Q8N3D4 ENST00000309295 1 0.87355 1.5271 NaN 1.1661 0.95961 NaN IWS1_C cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 4 4 4 5 5 5 91.954 5.7491E-06 25716000 12908000 12808000 3907 IPI:IPI00296432.1;IPI:IPI00386012.4;IPI:IPI00658007.2 Protein IWS1 homolog;IWS1-like protein IWS1;IWS1L Q96ST2-1;Q96ST2;Q96ST2-3;Q96ST2-2 ENST00000295321 3 0.80833 1.4571 0.79617 1.1098 0.91874 1.082 A_deaminase cell part;cytoplasmic part;cytosol;external side of plasma membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;lysosome;lytic vacuole;membrane part;membrane-bounded organelle;organelle;plasma membrane part;vacuole adenosine deaminase activity;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;protein binding;zinc ion binding adenosine catabolic process;cell activation;immune system process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;purine nucleoside catabolic process;purine nucleotide metabolic process;response to hypoxia Primary immunodeficiency;Purine metabolism 33 33 33 82.4 82.4 82.4 40.764 0 16316000000 9126900000 7189200000 3908 IPI:IPI00296441.5 Adenosine deaminase;Adenosine aminohydrolase ADA P00813 ENST00000372874;ENST00000396772 K01488 1 0.657 1.3292 0.62518 0.88077 0.83801 0.8217 cell projection;cell soma;cytoplasmic part;cytoskeletal part;cytosol;dendrite;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;microtubule;neuron projection;nucleus;organelle;organelle part actin binding;actin filament binding;beta-tubulin binding;binding;cytoskeletal protein binding;DNA binding;microtubule binding;nucleic acid binding;protein binding;tubulin binding anatomical structure morphogenesis;apoptosis;brain development;cell death;cytoskeleton organization;microtubule bundle formation;microtubule cytoskeleton organization;microtubule-based movement;microtubule-based process;organelle organization;transport 8 8 8 9.9 9.9 9.9 112.21 5.9652E-66 98088000 54028000 44060000 3909 IPI:IPI00296485.6 Microtubule-associated protein 1S;BPY2-interacting protein 1;Microtubule-associated protein 8;Variable charge Y chromosome 2-interacting protein 1;MAP1S heavy chain;MAP1S light chain MAP1S;BPY2IP1;C19orf5;MAP8;VCY2IP1 Q66K74 ENST00000324096 K10429 1 0.59616 1.2667 0.45695 0.73425 0.88164 0.5601 TPP_enzyme_C;TPP_enzyme_M;TPP_enzyme_N cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;microbody;organelle;peroxisome binding;carbon-carbon lyase activity;catalytic activity;cation binding;cofactor binding;identical protein binding;ion binding;lyase activity;magnesium ion binding;metal ion binding;protein binding;thiamin pyrophosphate binding;vitamin binding catabolic process;cellular process;fatty acid alpha-oxidation;fatty acid catabolic process;fatty acid metabolic process;lipid catabolic process;lipid metabolic process;metabolic process;organic acid catabolic process;organic acid metabolic process 4 4 4 7.1 7.1 7.1 63.728 3.3535E-10 12440000 7003300 5436200 3910 IPI:IPI00296535.1 2-hydroxyacyl-CoA lyase 1;2-hydroxyphytanoyl-CoA lyase;Phytanoyl-CoA 2-hydroxylase 2 HACL1;HPCL;HPCL2;PHYH2;HSPC279 Q9UJ83 ENST00000321169 K12261 1 0.69063 NaN 0.69453 0.90033 NaN 0.88746 Alpha-amylase;Alpha-amylase_C;CBM_48 cell part;cytoplasmic part;cytosol;intracellular part 1,4-alpha-glucan branching enzyme activity;binding;catalytic activity;hydrolase activity, hydrolyzing O-glycosyl compounds;transferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring hexosyl groups carbohydrate metabolic process;cellular glucan metabolic process;generation of precursor metabolites and energy;glycogen biosynthetic process;glycogen metabolic process;polysaccharide biosynthetic process;polysaccharide metabolic process Starch and sucrose metabolism 6 6 6 9.1 9.1 9.1 80.459 1.039E-30 46048000 24788000 21261000 3913 IPI:IPI00296635.5 1,4-alpha-glucan-branching enzyme;Glycogen-branching enzyme;Brancher enzyme GBE1 Q04446 ENST00000264326 K00700 1 0.6115 0.98138 0.69458 0.81175 0.68668 0.91339 Alpha_adaptinC2;GAT;VHS AP-type membrane coat adaptor complex;clathrin adaptor complex;endosomal part;endosome membrane;Golgi apparatus part;intracellular part;macromolecular complex;membrane;membrane part;organelle membrane;organelle part;protein complex;trans-Golgi network ADP-ribosylation factor binding;binding;enzyme binding;GTPase binding;protein binding;small GTPase binding cellular process;establishment of localization;establishment of localization in cell;establishment of protein localization;intracellular protein transport;intracellular transport;protein transport;transport;vesicle-mediated transport 4 3 3 7.7 6.5 6.5 67.15 6.5028E-12 47811000 25031000 22780000 3914 IPI:IPI00296772.4 ADP-ribosylation factor-binding protein GGA2;Golgi-localized, gamma ear-containing, ARF-binding protein 2;Gamma-adaptin-related protein 2;VHS domain and ear domain of gamma-adaptin GGA2;KIAA1080 Q9UJY4 ENST00000309859 K12404 1 NaN 1.0377 NaN NaN 0.73547 NaN DUF525;F-box;SMI1_KNR4 acid-amino acid ligase activity;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;small conjugating protein ligase activity;ubiquitin-protein ligase activity catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 2 2 2 4.9 4.9 4.9 54.56 2.7509E-05 1362100 647090 715020 3915 IPI:IPI00296789.2;IPI:IPI00472624.2 F-box only protein 3 FBXO3;FBX3 Q9UK99-1;Q9UK99;Q9UK99-2 ENST00000265651 K10290 2 0.75799 NaN 0.76496 1.0084 NaN 0.98812 CortBP2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 2 2 2 2.6 2.6 2.6 120.27 3.2121E-20 3561500 1962300 1599200 3916 IPI:IPI00296830.5;IPI:IPI00744623.1;IPI:IPI00395737.3 Leucine zipper protein 1 LUZP1 Q86V48-1;Q86V48;Q86V48-3;Q86V48-2 ENST00000374623 3 0.76672 1.5336 0.71896 1.0626 0.99465 0.97727 dCMP_cyt_deam_1 cell part;cytoplasmic part;cytosol;intracellular part binding;catalytic activity;dCMP deaminase activity;hydrolase activity;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines;zinc ion binding biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;nucleotide metabolic process;pyrimidine nucleotide metabolic process 5 5 5 44.4 44.4 44.4 21.014 3.8326E-78 46617000 23957000 22661000 3917 IPI:IPI00554705.1;IPI:IPI00296863.3 Deoxycytidylate deaminase;dCMP deaminase DCTD P32321-2;P32321;P32321-1 ENST00000312820;ENST00000357067 2 0.8441 1.5163 0.83719 1.0479 1.0132 1.0507 BRCT;PARP;VIT;VWA cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;ribonucleoprotein complex binding;catalytic activity;DNA binding;enzyme binding;NAD+ ADP-ribosyltransferase activity;nucleic acid binding;protein binding;transferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring pentosyl groups defense response;DNA metabolic process;DNA repair;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein amino acid ADP-ribosylation;protein modification process;response to stress;transport Base excision repair 5 5 5 3.5 3.5 3.5 192.59 5.6073E-21 10341000 5704600 4636800 3918 IPI:IPI00296909.3 Poly [ADP-ribose] polymerase 4;Vault poly(ADP-ribose) polymerase;193 kDa vault protein;PARP-related/IalphaI-related H5/proline-rich PARP4;ADPRTL1;KIAA0177;PARPL Q9UKK3 ENST00000381989 K10798 1 0.81932 1.4249 0.7977 1.0576 0.96839 1.0494 NUDIX cell part;intracellular binding;catalytic activity;magnesium ion binding;oxidoreductase activity;oxidoreductase activity, acting on CH or CH2 groups;protein binding;pyrophosphatase activity;ribonucleoside-diphosphate reductase activity alcohol metabolic process;carbohydrate metabolic process;D-ribose metabolic process;monosaccharide metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process Folate biosynthesis;Purine metabolism 11 11 11 42.9 42.9 42.9 24.327 1.8077E-175 2002600000 804740000 1197800000 3919 IPI:IPI00296913.1 ADP-sugar pyrophosphatase;Nucleoside diphosphate-linked moiety X motif 5;YSA1H NUDT5;HSPC115 Q9UKK9 ENST00000378937;ENST00000378952 K01515;K01529 1 0.98742 1.7175 1.7311 1.3116 1.1933 2.1828 DUF926 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 3 3 3 9.9 9.9 9.9 47.138 4.8008E-16 39794000 18233000 21561000 3920 IPI:IPI00296934.3;IPI:IPI00014757.4 NF-kappa-B-activating protein NKAP Q8N5F7 ENST00000371410 2 0.84018 2.6926 0.94237 1.1509 1.6671 1.2472 Macoilin cell part;integral to membrane;intrinsic to membrane;membrane part 3 3 3 4.4 4.4 4.4 76.177 1.4131E-06 64695000 34659000 30036000 3921 IPI:IPI00296938.1;IPI:IPI00373988.4;IPI:IPI00719801.1 Macoilin;Transmembrane protein 57 TMEM57 Q8N5G2-1;Q8N5G2;Q8N5G2-3;Q8N5G2-2 ENST00000374343;ENST00000399763;ENST00000399766 3 1.0859 2.1951 NaN 1.459 1.3199 NaN ATP12 cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;mitochondrion;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle;organelle part binding;protein binding anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex assembly;cellular macromolecular complex subunit organization;cellular process;protein complex assembly 2 2 2 6.9 6.9 6.9 32.772 1.2135E-15 7122800 4049800 3073000 3922 IPI:IPI00296999.9 ATP synthase mitochondrial F1 complex assembly factor 2;ATP12 homolog ATPAF2;ATP12;LP3663 Q8N5M1 ENST00000302530 K07556 1 0.4719 1.2686 0.6897 0.63943 0.86765 0.88558 Kelch_1;Muskelin_N cell part;cytoplasm;intracellular part binding;protein binding biological regulation;cell communication;cellular process;regulation of biological process;regulation of cellular process;signal transduction 4 4 4 6.7 6.7 6.7 84.767 7.6822E-30 23828000 12814000 11014000 3923 IPI:IPI00297045.5;IPI:IPI00815995.2 Muskelin MKLN1 Q9UL63-1;Q9UL63;Q9UL63-2 ENST00000352689 2 0.93996 1.6786 0.85265 1.1731 1.1736 1.0827 DDOST_48kD cell fraction;insoluble fraction;integral to membrane;intracellular part;intrinsic to membrane;macromolecular complex;membrane fraction;membrane part;microsome;oligosaccharyltransferase complex;organelle part;protein complex;vesicular fraction binding;catalytic activity;dolichyl-diphosphooligosaccharide-protein glycotransferase activity;oligosaccharyl transferase activity;protein binding;transferase activity;transferase activity, transferring glycosyl groups carbohydrate metabolic process;cell activation;immune system process;protein amino acid glycosylation;protein amino acid N-linked glycosylation;protein amino acid terminal glycosylation;protein modification process N-Glycan biosynthesis 17 17 17 51.5 51.5 51.5 50.8 4.6011E-183 1750000000 932470000 817560000 3924 IPI:IPI00297084.7 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit DDOST;KIAA0115;OST48;OK/SW-cl.45 P39656 ENST00000375048 K00730 1 0.49976 1.2081 0.52586 0.61893 0.77677 0.64772 NHL;zf-C3HC4 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;ion binding;ligase activity;protein binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding;transcription regulator activity;zinc ion binding catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis Ubiquitin mediated proteolysis 6 6 6 14.1 14.1 14.1 71.988 3.2977E-76 22672000 11684000 10988000 3925 IPI:IPI00297113.1 Tripartite motif-containing protein 32;Zinc finger protein HT2A;72 kDa Tat-interacting protein TRIM32;HT2A Q13049 ENST00000373983;ENST00000394497 K10607 1 0.98257 2.147 0.98451 1.3452 1.2987 1.3274 DUF602 9 9 9 31.7 31.7 31.7 33.854 4.9876E-94 130740000 63894000 66847000 3926 IPI:IPI00297121.5 UPF0549 protein C20orf43 C20orf43;AD-007;CDA05;HSPC164;HSPC169 Q9BY42 ENST00000023939 1 NaN 1.9562 0.69897 NaN 1.152 0.99578 fn3;Lep_receptor_Ig cell part;ciliary neurotrophic factor receptor complex;extracellular region;interleukin-6 receptor complex;macromolecular complex;membrane part;oncostatin-M receptor complex;plasma membrane part;protein complex;receptor complex binding;ciliary neurotrophic factor receptor activity;ciliary neurotrophic factor receptor binding;cytokine receptor activity;cytokine receptor binding;receptor activity;receptor binding;signal transducer activity;transmembrane receptor activity positive regulation of cytokine production;positive regulation of protein amino acid phosphorylation;regulation of acute inflammatory response;regulation of cytokine production;regulation of protein amino acid phosphorylation Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway 2 2 2 2 2 2 103.54 0.0052278 8573400 4683800 3889600 3927 IPI:IPI00297124.2;IPI:IPI00939624.1 Interleukin-6 receptor subunit beta;Interleukin-6 signal transducer;Membrane glycoprotein 130;CDw130;Oncostatin-M receptor subunit alpha IL6ST P40189-1;P40189;P40189-2 ENST00000336909;ENST00000346911;ENST00000381287;ENST00000381298 K05060 2 0.8552 1.6909 0.65292 1.0527 1.1911 1.0611 PARP cell part;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane part;membrane-bounded organelle;nucleus;organelle catalytic activity;NAD+ ADP-ribosyltransferase activity;transferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring pentosyl groups 2 2 2 9.3 9.3 9.3 36.469 0.0010359 4165400 2348000 1817400 3928 IPI:IPI00297151.3;IPI:IPI00794653.1 Poly [ADP-ribose] polymerase 16 PARP16;C15orf30 Q8N5Y8-3;Q8N5Y8;Q8N5Y8-1 ENST00000261888 2 0.81998 1.4783 0.74237 1.0889 0.93263 0.93665 SAM_2;SH2 cell part;cytoplasmic part;cytosol;intracellular part binding;protein binding cell communication;cell surface receptor linked signal transduction;enzyme linked receptor protein signaling pathway;immune response;immune system process;signal transduction;transmembrane receptor protein tyrosine kinase signaling pathway Fc epsilon RI signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway 11 11 11 25 25 25 60.187 1.2577E-131 131200000 70947000 60249000 3929 IPI:IPI00297169.1 Lymphocyte cytosolic protein 2;SH2 domain-containing leukocyte protein of 76 kDa;SLP-76 tyrosine phosphoprotein LCP2 Q13094 ENST00000046794 K07361 1 0.91648 1.529 NaN 1.182 1.0153 NaN MED14 cell part;intracellular organelle part;intracellular part;macromolecular complex;mediator complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;protein binding;receptor activity;receptor binding;RNA polymerase II transcription factor activity;signal transducer activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding cell communication;intracellular signaling cascade;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;signal transduction;transcription initiation;transcription initiation from RNA polymerase II promoter 6 6 6 7.1 7.1 7.1 160.6 7.5683E-51 10377000 5573200 4804000 3930 IPI:IPI00297191.2 Mediator of RNA polymerase II transcription subunit 14;Mediator complex subunit 14;Cofactor required for Sp1 transcriptional activation subunit 2;CRSP complex subunit 2;Transcriptional coactivator CRSP150;Vitamin D3 receptor-interacting protein complex 150 kDa component;Thyroid hormone receptor-associated protein complex 170 kDa component;Activator-recruited cofactor 150 kDa component MED14;ARC150;CRSP2;CXorf4;DRIP150;EXLM1;RGR1;TRAP170 O60244 ENST00000324817 1 0.95243 1.7617 0.93885 1.2529 1.1492 1.2422 HAND;Helicase_C;SLIDE;SNF2_N chromatin remodeling complex;chromosome;condensed chromosome;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;organelle;organelle part;protein complex;RSF complex ATP binding;binding;catalytic activity;chromatin binding;DNA binding;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;RNA polymerase II transcription factor activity chromatin assembly or disassembly;chromatin organization;chromatin remodeling;nucleosome assembly;organelle organization;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription initiation 39 39 27 40 40 30.4 121.9 7.0375E-206 1608400000 684650000 923800000 3931 IPI:IPI00297211.1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5;Sucrose nonfermenting protein 2 homolog SMARCA5;SNF2H;WCRF135 O60264 ENST00000283131 K11654 1 0.75948 1.6029 0.7676 1.009 1.0256 1.0632 2 2 2 2.6 2.6 2.6 96.753 3.0223E-31 28970000 13751000 15219000 3932 IPI:IPI00297212.5 Paladin PALD;KIAA1274 Q9ULE6 ENST00000263563 1 0.492 0.95247 0.45553 0.65343 0.66242 0.60507 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;protein binding 19 19 19 10.3 10.3 10.3 254.39 2.3075E-189 147970000 86120000 61850000 3933 IPI:IPI00297241.4 Nucleolar pre-ribosomal-associated protein 1 URB1;C21orf108;KIAA0539;NPA1 O60287 ENST00000382751 1 0.84533 1.7797 0.81186 1.0982 1.1901 1.0598 Y_phosphatase cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;intracellular organelle part;intracellular part;membrane;membrane part;organelle membrane;organelle part binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;phosphatase activity;phosphoprotein phosphatase activity;phosphoric ester hydrolase activity;protein binding;protein tyrosine phosphatase activity;zinc ion binding negative regulation of cell communication;negative regulation of signal transduction;regulation of cell communication;regulation of insulin receptor signaling pathway;regulation of signal transduction Adherens junction;Insulin signaling pathway 15 15 15 38.4 38.4 38.4 49.966 7.3475E-233 472550000 246080000 226470000 3934 IPI:IPI00297261.3 Tyrosine-protein phosphatase non-receptor type 1;Protein-tyrosine phosphatase 1B PTPN1;PTP1B P18031 ENST00000371621 K05696 1 0.95434 1.6495 1.0507 1.2418 1.0804 1.3198 ArfGap cell part;cytoplasmic part;Golgi apparatus part;Golgi membrane;intracellular organelle part;intracellular part;membrane;organelle membrane;organelle part ARF GTPase activator activity;binding;cation binding;enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;ion binding;metal ion binding;small GTPase regulator activity;zinc ion binding cellular process;establishment of protein localization;protein transport;regulation of ARF GTPase activity;regulation of catalytic activity;regulation of GTPase activity;regulation of Ras GTPase activity;transport;vesicle-mediated transport 6 6 6 13.1 13.1 13.1 56.72 4.7031E-29 125370000 62527000 62840000 3936 IPI:IPI00297322.3 ADP-ribosylation factor GTPase-activating protein 2;GTPase-activating protein ZNF289;Zinc finger protein 289 ARFGAP2;ZNF289;Nbla10535 Q8N6H7 ENST00000319543 1 0.62041 0.93168 0.45841 0.90322 0.55823 0.61724 G-patch cell part;chromosomal part;chromosome, telomeric region;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;nucleic acid binding;protein binding cell cycle;cellular process;negative regulation of biological process;negative regulation of cell cycle;negative regulation of cell proliferation;negative regulation of cellular process;regulation of biological process;regulation of cell proliferation 4 4 4 20.7 20.7 20.7 37.034 2.1345E-33 264900000 139850000 125050000 3937 IPI:IPI00297357.1;IPI:IPI00385561.1 Pin2-interacting protein X1;TRF1-interacting protein 1;Liver-related putative tumor suppressor;Protein 67-11-3 PINX1;LPTL;LPTS Q96BK5-1;Q96BK5 ENST00000314787;ENST00000354846 K11135 2 0.90084 1.6593 1.0025 1.2023 1.0508 1.3095 AKAP95 cell part;chromosome;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear matrix;nuclear part;organelle;organelle part binding;cation binding;DEAD/H-box RNA helicase binding;DNA binding;enzyme binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transition metal ion binding;zinc ion binding 5 5 5 8.5 8.5 8.5 71.639 9.1401E-07 155360000 81552000 73806000 3938 IPI:IPI00297455.5 A-kinase anchor protein 8-like;Neighbor of A-kinase-anchoring protein 95;Homologous to AKAP95 protein;Helicase A-binding protein 95 AKAP8L;NAKAP95;HRIHFB2018 Q9ULX6 ENST00000263378 1 0.88035 1.5587 0.84016 1.2304 1.004 1.1056 MATH;zf-C3HC4;zf-TRAF cell part;cytoplasm;intracellular part binding;cation binding;ion binding;metal ion binding;molecular transducer activity;protein binding;signal transducer activity;transition metal ion binding;zinc ion binding apoptosis;cell communication;cell death;cellular process;death;induction of apoptosis;induction of programmed cell death;positive regulation of cell death;programmed cell death;regulation of apoptosis;regulation of cell death;signal transduction Pathways in cancer;Small cell lung cancer;Toll-like receptor signaling pathway 2 2 2 4.4 4.4 4.4 64.489 6.1218E-47 6052900 3166100 2886800 3939 IPI:IPI00297473.2 TNF receptor-associated factor 3;CD40 receptor-associated factor 1;CD40-binding protein;LMP1-associated protein;LAP1;CAP-1 TRAF3;CAP1;CRAF1 Q13114 ENST00000351691;ENST00000392745 K03174 1 0.79973 1.4862 0.73944 1.0201 0.99006 0.95502 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;small nuclear ribonucleoprotein complex;U2 snRNP binding;nucleic acid binding;protein binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 12 12 12 36.9 36.9 36.9 28.415 7.2221E-217 1470000000 811110000 658860000 3940 IPI:IPI00297477.3 U2 small nuclear ribonucleoprotein A' SNRPA1 P09661 ENST00000254193 K11092 1 0.91624 1.794 0.90496 1.1707 1.1928 1.1902 STT3 cell part;cytoplasmic part;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;macromolecular complex;membrane part;oligosaccharyltransferase complex;organelle part;protein complex catalytic activity;dolichyl-diphosphooligosaccharide-protein glycotransferase activity;oligosaccharyl transferase activity;transferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring hexosyl groups carbohydrate metabolic process;cellular process;metabolic process;peptidyl-amino acid modification;peptidyl-asparagine modification;protein amino acid glycosylation;protein amino acid N-linked glycosylation;protein modification process 15 15 14 19.1 19.1 18.3 80.529 4.2479E-104 764990000 390670000 374320000 3941 IPI:IPI00297492.2 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A;B5;Integral membrane protein 1;Transmembrane protein TMC STT3A;ITM1;TMC P46977 ENST00000392708 K07151 1 0.60397 1.2618 0.5671 0.83422 0.83834 0.77377 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;RNA binding cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 31 31 31 21.7 21.7 21.7 171.38 4.5384E-304 417510000 234550000 182960000 3942 IPI:IPI00297572.5 Intron-binding protein aquarius;Intron-binding protein of 160 kDa AQR;KIAA0560 O60306 ENST00000156471 1 1.3659 NaN NaN 2.0067 NaN NaN CortBP2 cytoplasm;cytoskeletal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane;membrane-bounded organelle;myosin complex;nucleus;organelle;organelle part;protein complex 3 3 3 3.5 3.5 3.5 130.38 2.7564E-05 17650000 8622000 9027700 3943 IPI:IPI00297578.5;IPI:IPI00477324.3;IPI:IPI00922540.1;IPI:IPI00748547.3;IPI:IPI00877049.1;IPI:IPI00922613.1;IPI:IPI00658170.2 Filamin A-interacting protein 1-like;130 kDa GPBP-interacting protein;90 kDa GPBP-interacting protein;Protein down-regulated in ovarian cancer 1 FILIP1L;COL4A3BPIP;DOC1;GIP90 Q4L180-1;Q4L180;Q4L180-2 ENST00000331335;ENST00000354552;ENST00000383694;ENST00000398326 7 0.69517 1.4335 0.79369 0.94599 0.88627 1.0786 Chromo;Chromo_shadow centromeric heterochromatin;chromatin;chromosome, centromeric region;condensed chromosome, centromeric region;euchromatin;heterochromatin;nuclear chromatin;nuclear euchromatin;nuclear heterochromatin;nuclear inner membrane;polytene chromosome chromocenter binding;chromatin binding;general transcriptional repressor activity;protein binding;protein domain specific binding;transcription regulator activity;transcription repressor activity chromatin assembly or disassembly;chromatin organization;chromatin remodeling;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 9 8 7 43.7 37.2 28.4 20.811 1.5024E-293 1854700000 955430000 899290000 3944 IPI:IPI00297579.4 Chromobox protein homolog 3;Heterochromatin protein 1 homolog gamma;Modifier 2 protein;HECH CBX3 Q13185 ENST00000337620;ENST00000396386 K11586 1 0.6024 1.4757 NaN 0.77319 0.96074 NaN UCH catalytic activity;cysteine-type peptidase activity;hydrolase activity;hydrolase activity, acting on ester bonds;peptidase activity;peptidase activity, acting on L-amino acid peptides;thiolester hydrolase activity;ubiquitin thiolesterase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process 5 5 5 1.6 1.6 1.6 404.23 9.3654E-09 7691200 3914000 3777200 3945 IPI:IPI00297593.4;IPI:IPI00894492.3;IPI:IPI00787401.2 Ubiquitin carboxyl-terminal hydrolase 34;Ubiquitin thioesterase 34;Ubiquitin-specific-processing protease 34;Deubiquitinating enzyme 34 USP34;KIAA0570;KIAA0729 Q70CQ2-1;Q70CQ2;Q70CQ2-3;Q70CQ2-2 ENST00000398569;ENST00000398571 K11853 3 0.60582 1.1079 0.67428 0.82453 0.70862 0.89745 Sec1 cell part;cytoplasmic part;cytosol;intracellular part;membrane;plasma membrane cellular process;establishment of localization;establishment of protein localization;membrane docking;protein transport;transport;vesicle docking;vesicle docking during exocytosis 8 8 8 14.5 14.5 14.5 67.764 2.1294E-59 87710000 51204000 36506000 3946 IPI:IPI00297626.4 Syntaxin-binding protein 3;Unc-18 homolog 3;Unc-18C;Platelet Sec1 protein STXBP3 O00186 ENST00000370008 1 NaN 0.95888 NaN NaN 0.6528 NaN G-patch cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;RNA binding;transition metal ion binding;zinc ion binding cellular biopolymer metabolic process;cellular process;macromolecule metabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing 3 3 3 4.1 4.1 4.1 128.64 2.6205E-17 955220 444730 510490 3948 IPI:IPI00297723.2 RNA-binding protein 6;RNA-binding motif protein 6;RNA-binding protein DEF-3;Lung cancer antigen NY-LU-12;Protein G16 RBM6;DEF3 P78332 ENST00000266022 1 0.89277 1.6922 0.90585 1.159 1.1225 1.1854 Cpn60_TCP1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 43 43 43 80.4 80.4 80.4 57.488 0 13283000000 6876200000 6406800000 3949 IPI:IPI00297779.7 T-complex protein 1 subunit beta;CCT-beta CCT2;99D8.1;CCTB P78371 ENST00000299300 K09494 1 0.78481 1.3706 0.78982 1.0431 0.89172 1.0172 Chromo;Helicase_C;SNF2_N cell part;chromatin;chromosomal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;nucleus;organelle;organelle part ATP binding;ATP-dependent DNA helicase activity;binding;catalytic activity;chromatin binding;DNA binding;DNA helicase activity;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding cellular process;chromatin assembly or disassembly;chromatin organization;organelle organization;regulation of biosynthetic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent 20 20 19 13.8 13.8 13.3 196.69 1.0534E-59 2582900000 1362500000 1220300000 3950 IPI:IPI00297851.1;IPI:IPI00954192.1;IPI:IPI00815893.1;IPI:IPI00023109.2 Chromodomain-helicase-DNA-binding protein 1;ATP-dependent helicase CHD1 CHD1 O14646-1;O14646;O14646-2 ENST00000284049 K11367 4 0.58527 1.3004 NaN 0.73821 0.9092 NaN FYRC;FYRN;HMG_box;PHD;SET cell part;histone methyltransferase complex;intracellular organelle part;intracellular part;macromolecular complex;methyltransferase complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;catalytic activity;DNA binding;methyltransferase activity;N-methyltransferase activity;nucleic acid binding;protein binding;protein methyltransferase activity;S-adenosylmethionine-dependent methyltransferase activity;zinc ion binding biosynthetic process;chromatin organization;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;regulation of transcription, DNA-dependent;transcription 2 2 2 0.7 0.7 0.7 564.47 6.4262E-08 471510 268670 202840 3951 IPI:IPI00377245.1;IPI:IPI00297859.1;IPI:IPI00377244.1 Histone-lysine N-methyltransferase MLL2;Myeloid/lymphoid or mixed-lineage leukemia protein 2;ALL1-related protein;Lysine N-methyltransferase 2B MLL2;ALR;KMT2B O14686-3;O14686;O14686-1;O14686-2 ENST00000301067 K09187 3 0.34741 0.84141 0.46108 0.54637 0.51541 0.56882 DEAD;Helicase_C cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;plasma membrane ATP binding;ATP-dependent helicase activity;binding;catalytic activity;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity;RNA binding;RNA helicase activity 14 14 14 16 16 16 100.89 5.1969E-83 111630000 63716000 47914000 3952 IPI:IPI00297900.4 Probable ATP-dependent RNA helicase DDX10;DEAD box protein 10 DDX10 Q13206 ENST00000322536 1 1.0789 2.013 1.2831 1.4579 1.3729 1.6341 AP-1 adaptor complex;AP-type membrane coat adaptor complex;clathrin adaptor complex;cytoplasmic part;cytoplasmic vesicle part;Golgi apparatus part;intracellular part;macromolecular complex;membrane part;organelle part;protein complex binding;calcium ion binding;cation binding;ion binding;metal ion binding cellular component organization;cellular process;endocytosis;establishment of protein localization;intracellular protein transport;intracellular transport;membrane invagination;membrane organization;protein transport;transport;vesicle-mediated transport 7 7 7 6.3 6.3 6.3 140.65 2.6634E-103 20149000 9876000 10273000 3953 IPI:IPI00297931.4;IPI:IPI00827622.2;IPI:IPI00798416.3 AP1 subunit gamma-binding protein 1;Gamma-synergin AP1GBP1;SYNG Q9UMZ2-1;Q9UMZ2;Q9UMZ2-3;Q9UMZ2-4 ENST00000339208;ENST00000346661;ENST00000394379 3 0.57627 1.0847 0.56158 0.74909 0.71861 0.7183 eIF2_C;GTP_EFTU;GTP_EFTU_D2 cell part;cytoplasmic part;cytosol;intracellular part binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;nucleic acid binding;nucleotide binding;protein binding;pyrophosphatase activity;translation factor activity, nucleic acid binding;translation initiation factor activity biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation;translational initiation 27 27 27 54.9 54.9 54.9 51.109 0 4646900000 2575600000 2071300000 3954 IPI:IPI00297982.7;IPI:IPI00900305.1;IPI:IPI00900297.1 Eukaryotic translation initiation factor 2 subunit 3;Eukaryotic translation initiation factor 2 subunit gamma;Eukaryotic translation initiation factor 2 subunit 3-like protein EIF2S3;EIF2G P41091;Q2VIR3-1;Q2VIR3;Q2VIR3-2 ENST00000253039;ENST00000322446 3 0.82092 1.4434 0.72891 1.0642 0.94813 0.97101 KOW;Supt5 cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;enzyme binding;negative transcription elongation factor activity;positive transcription elongation factor activity;protein binding;protein heterodimerization activity;transcription elongation regulator activity;transcription regulator activity chromatin organization;chromatin remodeling;negative regulation of transcription from RNA polymerase II promoter;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;RNA elongation 19 19 19 20.4 20.4 20.4 121 0 442320000 229390000 212940000 3955 IPI:IPI00298058.1;IPI:IPI00655641.1 Transcription elongation factor SPT5;DRB sensitivity-inducing factor large subunit;DSIF p160;Tat-cotransactivator 1 protein SUPT5H;SPT5;SPT5H O00267-1;O00267;O00267-2 ENST00000378524;ENST00000402194 2 0.42168 NaN 0.61984 0.55319 NaN 0.84648 BmKX;Ephrin_lbd;fn3;Pkinase_Tyr;SAM_1;SAM_2 cell part;extracellular region;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;catalytic activity;nucleoside binding;nucleotide binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cell communication;cell surface receptor linked signal transduction;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;signal transduction Axon guidance 2 2 2 2.6 2.6 2.6 110.13 4.9778E-05 3881400 2119000 1762500 3956 IPI:IPI00298105.4;IPI:IPI00008290.3;IPI:IPI00215945.3 Ephrin type-A receptor 3;Tyrosine-protein kinase receptor ETK1;HEK;HEK4;Tyrosine-protein kinase TYRO4;Ephrin type-A receptor 5;Tyrosine-protein kinase receptor EHK-1;EPH homology kinase 1;Receptor protein-tyrosine kinase HEK7 EPHA3;ETK;ETK1;HEK;TYRO4;EPHA5;EHK1;HEK7 P29320-1;P29320;P54756-1;P54756;P54756-2 ENST00000336596;ENST00000273854;ENST00000354839 K05104;K05106 3 0.82943 1.7927 0.92582 1.1534 1.1175 1.2149 PX;Vps5 cell part;cytoplasm;intracellular part binding;identical protein binding;lipid binding;phosphoinositide binding;phospholipid binding;protein binding;protein dimerization activity;protein homodimerization activity cell communication;intracellular protein transport;negative regulation of epidermal growth factor receptor activity;negative regulation of protein kinase activity;regulation of epidermal growth factor receptor activity;transport 13 13 13 31.3 31.3 31.3 47.804 3.0184E-229 442620000 243140000 199480000 3957 IPI:IPI00298111.7;IPI:IPI00396025.8;IPI:IPI00885014.1 Sorting nexin-6;TRAF4-associated factor 2 SNX6 Q9UNH7 ENST00000396534 3 0.82908 1.8182 0.83219 1.0179 1.1797 0.98328 Acyl_CoA_thio cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;microbody;organelle;peroxisome acyl-CoA thioesterase activity;binding;carboxylesterase activity;catalytic activity;choloyl-CoA hydrolase activity;CoA hydrolase activity;hydrolase activity;hydrolase activity, acting on ester bonds;protein binding;thiolester hydrolase activity acyl-CoA metabolic process;cellular component organization;cellular process;coenzyme metabolic process;fatty acid metabolic process;lipid metabolic process;metabolic process;organelle organization;organic acid metabolic process;peroxisome organization 3 3 3 15 15 15 35.914 1.4956E-86 26387000 14428000 11959000 3958 IPI:IPI00298202.1 Acyl-coenzyme A thioesterase 8;Choloyl-coenzyme A thioesterase;Acyl-CoA thioesterase 8;Peroxisomal acyl-coenzyme A thioester hydrolase 1;Peroxisomal long-chain acyl-CoA thioesterase 1;HIV-Nef-associated acyl-CoA thioesterase;Thioesterase II;PTE-2 ACOT8;ACTEIII;PTE1;PTE2 O14734 ENST00000217455 K11992 1 NaN 0.99564 NaN NaN 0.70883 NaN cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 2 2 2 4.8 4.8 4.8 61.967 5.0675E-75 2249200 1193200 1056000 3959 IPI:IPI00298373.9;IPI:IPI00044665.2 Protein FAM117B;Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein FAM117B;ALS2CR13 Q6P1L5-1;Q6P1L5;Q6P1L5-2 ENST00000303116 2 0.78647 1.2336 0.66192 1.0008 0.83182 0.91522 PI3_PI4_kinase;PI3K_C2;PI3K_p85B;PI3K_rbd;PI3Ka cell part;cytoplasmic part;cytosolic part;intracellular part;macromolecular complex;phosphoinositide 3-kinase complex;protein complex 1-phosphatidylinositol-3-kinase activity;ATP binding;binding;catalytic activity;inositol or phosphatidylinositol kinase activity;kinase activity;lipid kinase activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding cell communication;glycerophospholipid metabolic process;lipid metabolic process;phosphate metabolic process;phospholipid metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;signal transduction Acute myeloid leukemia;Apoptosis;B cell receptor signaling pathway;Chemokine signaling pathway;Chronic myeloid leukemia;Colorectal cancer;Endometrial cancer;ErbB signaling pathway;Fc epsilon RI signaling pathway;Focal adhesion;Glioma;Inositol phosphate metabolism;Insulin signaling pathway;Jak-STAT signaling pathway;Leukocyte transendothelial migration;Melanoma;mTOR signaling pathway;Natural killer cell mediated cytotoxicity;Non-small cell lung cancer;Pancreatic cancer;Pathways in cancer;Phosphatidylinositol signaling system;Progesterone-mediated oocyte maturation;Prostate cancer;Regulation of actin cytoskeleton;Renal cell carcinoma;Small cell lung cancer;T cell receptor signaling pathway;Toll-like receptor signaling pathway;Type II diabetes mellitus;VEGF signaling pathway 4 4 4 6.1 6.1 6.1 119.48 4.0451E-15 8333100 4439800 3893300 3960 IPI:IPI00298410.2 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform;PI3-kinase p110 subunit delta;PtdIns-3-kinase p110;p110delta PIK3CD O00329 ENST00000361110;ENST00000377346 K00922 1 0.87092 1.9158 NaN 1.181 1.2105 NaN 2-oxoacid_dh;Biotin_lipoyl;E3_binding cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part acyltransferase activity;binding;carboxylic acid binding;catalytic activity;lipoic acid binding;protein binding;transferase activity;transferase activity, transferring acyl groups;transferase activity, transferring acyl groups other than amino-acyl groups metabolic process 5 5 5 12.2 12.2 12.2 54.122 8.6438E-63 33872000 23999000 9873200 3961 IPI:IPI00298423.3 Pyruvate dehydrogenase protein X component, mitochondrial;Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex;Lipoyl-containing pyruvate dehydrogenase complex component X;E3-binding protein;proX PDHX;PDX1 O00330 ENST00000227868 1 0.4117 0.92423 0.49812 0.54927 0.55877 0.63043 SpoU_methylase cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;methyltransferase activity;nucleic acid binding;RNA binding;RNA methyltransferase activity;transferase activity;transferase activity, transferring one-carbon groups metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;RNA processing 8 8 8 6.7 6.7 6.7 181.67 4.1839E-57 19579000 13010000 6569600 3962 IPI:IPI00298447.3 Probable methyltransferase TARBP1;TAR RNA-binding protein 1;TAR RNA-binding protein of 185 kDa TARBP1;TRM3;TRP185 Q13395 ENST00000040877 1 0.86582 1.7189 0.86616 1.1445 1.1031 1.1506 DJ-1_PfpI cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding biological regulation;cell communication;cellular process;intracellular signaling cascade;Ras protein signal transduction;regulation of biological process;regulation of cellular process;signal transduction;small GTPase mediated signal transduction Parkinson's disease 15 15 15 85.2 85.2 85.2 19.891 0 3932200000 2151000000 1781200000 3963 IPI:IPI00298547.3 Protein DJ-1;Oncogene DJ1;Parkinson disease protein 7 PARK7 Q99497 ENST00000338639;ENST00000377488;ENST00000377491;ENST00000377493 K05687 1 0.76075 1.614 0.78687 0.97715 1.0126 1.0432 DUF1241 binding;protein binding apoptosis;cell death;cellular process;death;programmed cell death 8 8 8 38.2 38.2 38.2 24.701 4.6689E-22 300280000 155250000 145030000 3964 IPI:IPI00298558.2 Programmed cell death protein 10;TF-1 cell apoptosis-related protein 15;Cerebral cavernous malformations 3 protein PDCD10;CCM3;TFAR15 Q9BUL8 ENST00000337295;ENST00000392750;ENST00000392751 1 0.784 1.3565 0.74224 1.0315 0.96866 0.93197 BCDHK_Adom3;HATPase_c cytoplasmic part;intracellular organelle part;intracellular part;macromolecular complex;mitochondrial alpha-ketoglutarate dehydrogenase complex;mitochondrial part;mitochondrial tricarboxylic acid cycle enzyme complex;organelle part;protein complex binding;catalytic activity;nucleoside binding;nucleotide binding;protein histidine kinase activity;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;signal transducer activity;two-component sensor activity cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;organic acid metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process 5 5 5 13.3 13.3 13.3 46.36 1.4025E-16 21169000 10052000 11116000 3965 IPI:IPI00298612.1 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial;Branched-chain alpha-ketoacid dehydrogenase kinase BCKDK O14874 ENST00000219794;ENST00000394951 1 0.9705 2.0274 1.0946 1.2163 1.3877 1.3187 eIF-1a binding;nucleic acid binding;RNA binding;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity cellular process;translational initiation 3 3 3 24.8 24.8 24.8 19.053 7.6519E-65 85932000 40817000 45115000 3966 IPI:IPI00298618.1 Probable RNA-binding protein EIF1AD;Eukaryotic translation initiation factor 1A domain-containing protein;Haponin EIF1AD Q8N9N8 ENST00000312234 1 0.66944 1.4355 0.88006 0.87576 0.97473 1.1051 Treacle cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;protein binding;transporter activity anatomical structure development;developmental process;establishment of localization;skeletal system development;system development;transport 11 11 11 9.1 9.1 9.1 156.06 1.0126E-230 500720000 213590000 287130000 3968 IPI:IPI00815713.2;IPI:IPI00815944.1;IPI:IPI00815731.1;IPI:IPI00298696.2;IPI:IPI00555853.2 Treacle protein;Treacher Collins syndrome protein TCOF1 Q13428-4;Q13428;Q13428-3;Q13428-1;Q13428-2;Q13428-5 ENST00000323668;ENST00000377797;ENST00000394269 5 0.66492 1.2818 0.59375 0.92764 0.84712 0.81617 zf-CCCH cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;enzyme inhibitor activity;nucleic acid binding;phosphatase inhibitor activity;phosphatase regulator activity;phosphoprotein phosphatase inhibitor activity;protein binding;RNA binding;zinc ion binding intracellular protein transport;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleocytoplasmic transport;protein import into nucleus;protein targeting;transcription;transport 8 8 8 8.6 8.6 8.6 99.057 7.583E-81 50163000 28464000 21699000 3969 IPI:IPI00298731.2 Serine/threonine-protein phosphatase 1 regulatory subunit 10;Phosphatase 1 nuclear targeting subunit;MHC class I region proline-rich protein CAT53;FB19 protein;PP1-binding protein of 114 kDa;p99 PPP1R10;CAT53;FB19;PNUTS Q96QC0 ENST00000376511;ENST00000383430;ENST00000383586 1 0.66959 1.2547 0.58547 0.84139 0.82411 0.77872 RNA_pol cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial nucleoid;mitochondrial part;nucleoid;organelle part binding;catalytic activity;DNA binding;DNA-directed RNA polymerase activity;nucleic acid binding;nucleotidyltransferase activity;protein binding;RNA polymerase activity;transferase activity;transferase activity, transferring phosphorus-containing groups mitochondrion organization;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;transcription;transcription from mitochondrial promoter;transcription, DNA-dependent 18 18 18 17.4 17.4 17.4 140.21 2.9893E-89 135430000 73324000 62105000 3970 IPI:IPI00298738.3 DNA-directed RNA polymerase, mitochondrial;MtRPOL POLRMT O00411 ENST00000215591 K10908 1 0.77084 1.4694 0.75535 0.97572 0.98406 0.96502 dsrm;DZF intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;DNA binding;double-stranded RNA binding;nucleic acid binding;protein binding;RNA binding;transcription activator activity;transcription regulator activity;transcription repressor activity biosynthetic process;M phase;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 30 30 26 39.4 39.4 35.3 95.807 0 4826200000 2563800000 2262300000 3971 IPI:IPI00418313.3;IPI:IPI00298788.4;IPI:IPI00414335.2;IPI:IPI00556173.1;IPI:IPI00298789.2;IPI:IPI00219330.2 Interleukin enhancer-binding factor 3;Nuclear factor of activated T-cells 90 kDa;Double-stranded RNA-binding protein 76;Translational control protein 80;Nuclear factor associated with dsRNA;M-phase phosphoprotein 4 ILF3;DRBF;MPHOSPH4;NF90 Q12906-4;Q12906;Q12906-1;Q12906-3;Q12906-6;Q12906-2;Q12906-5 ENST00000250241;ENST00000318511;ENST00000336059;ENST00000407004 6 0.71406 1.3399 NaN 0.93231 0.95299 NaN cell part;cytoplasmic part;Golgi apparatus;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane part;membrane-bounded organelle;organelle cation transmembrane transporter activity;ion transmembrane transporter activity;monovalent inorganic cation transmembrane transporter activity;sodium ion transmembrane transporter activity;transmembrane transporter activity;transporter activity cation transport;cellular process;establishment of localization;ion transport;metal ion transport;monovalent inorganic cation transport;sodium ion transport;transport;vesicle-mediated transport 3 3 3 3.3 3.3 3.3 142.19 8.6491E-18 2637200 1432400 1204700 3974 IPI:IPI00298870.1 Trafficking protein particle complex subunit 10;Transport protein particle subunit TMEM1;Trafficking protein particle complex subunit TMEM1;Epilepsy holoprosencephaly candidate 1 protein;Protein GT334 TRAPPC10;EHOC1;TMEM1 P48553 ENST00000291574 1 0.79606 1.6936 0.81073 1.0777 1.0866 1.0565 centrosome;cytoplasmic part;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;microtubule organizing center;non-membrane-bounded organelle;organelle;organelle part cell differentiation;cellular developmental process;cellular process;developmental process;gamete generation;male gamete generation;multicellular organismal development;multicellular organismal process;reproductive process;spermatogenesis 4 4 4 5.1 5.1 5.1 122.06 4.9288E-07 23178000 13034000 10144000 3975 IPI:IPI00298883.7;IPI:IPI00651721.1 5-azacytidine-induced protein 1;Pre-acrosome localization protein 1;Centrosomal protein of 131 kDa AZI1;CEP131;KIAA1118 Q9UPN4-1;Q9UPN4;Q9UPN4-2 ENST00000269392 2 0.71617 1.2843 0.51032 0.86075 0.93215 0.62352 TFIID_90kDa;WD40 cytoplasm;cytoskeleton;histone acetyltransferase complex;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;organelle;transcription factor complex;transcription factor TFIID complex;transcription factor TFTC complex binding;DNA binding;nucleic acid binding;promoter binding;protein binding;protein dimerization activity;sequence-specific DNA binding;transcription factor activity;transcription regulator activity chromatin organization;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;RNA elongation;transcription initiation;transcription initiation from RNA polymerase II promoter Basal transcription factors 4 4 4 6.2 6.2 6.2 86.829 1.4448E-55 34958000 19540000 15419000 3976 IPI:IPI00298925.2;IPI:IPI00298926.4 Transcription initiation factor TFIID subunit 5;Transcription initiation factor TFIID 100 kDa subunit TAF5;TAF2D Q15542-1;Q15542;Q15542-2 ENST00000351396;ENST00000369839 K03130 2 NaN 0.89399 NaN NaN 0.63069 NaN LRR_1 cell part;cytoplasm;intracellular part binding;protein binding cell communication;cell surface receptor linked signal transduction;enzyme linked receptor protein signaling pathway;intracellular signaling cascade;signal transduction;transmembrane receptor protein tyrosine kinase signaling pathway 3 3 3 7.2 7.2 7.2 64.887 1.3825E-18 5579000 5065400 513600 3977 IPI:IPI00298928.1;IPI:IPI00479890.4 Leucine-rich repeat protein SHOC-2;Ras-binding protein Sur-8 SHOC2;KIAA0862 Q9UQ13-1;Q9UQ13;Q9UQ13-2 ENST00000369452 2 0.73118 1.171 0.71743 0.92014 0.75187 0.98224 JmjC cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;iron ion binding;oxidoreductase activity;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen;zinc ion binding biosynthetic process;chromatin organization;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;regulation of transcription, DNA-dependent;transcription 8 8 8 6.1 6.1 6.1 191.61 2.2692E-93 64759000 35572000 29187000 3978 IPI:IPI00298935.4;IPI:IPI00749486.1;IPI:IPI00748132.1 Lysine-specific demethylase 3B;JmjC domain-containing histone demethylation protein 2B;Jumonji domain-containing protein 1B;Nuclear protein 5qNCA KDM3B;C5orf7;JHDM2B;JMJD1B;KIAA1082 Q7LBC6-1;Q7LBC6;Q7LBC6-2 ENST00000314358;ENST00000394866 K11449 3 1.749 3.4069 1.5679 2.194 2.2415 2.0694 Pkinase centrosome;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;microtubule organizing center;non-membrane-bounded organelle;nucleus;organelle;organelle part;spindle ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cytoskeleton organization;microtubule cytoskeleton organization;microtubule-based process;nuclear division;organelle organization;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process 10 10 9 32.3 32.3 30.3 45.809 1.1829E-81 100230000 51045000 49181000 3979 IPI:IPI00298940.3;IPI:IPI00099756.1;IPI:IPI00332343.3 Serine/threonine-protein kinase 6;Aurora kinase A;Serine/threonine kinase 15;Aurora/IPL1-related kinase 1;Breast tumor-amplified kinase AURKA;AIK;ARK1;AURA;BTAK;STK15;STK6 O14965 ENST00000312783;ENST00000347343;ENST00000371356;ENST00000395909;ENST00000395911;ENST00000395913;ENST00000395914;ENST00000395915 K11481 3 0.84647 1.7908 0.79896 1.1388 1.2417 1.0335 Vps26 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane part;membrane-bounded organelle;nucleus;organelle;protein complex;retromer complex establishment of localization;establishment of localization in cell;intracellular transport;transport;vacuolar transport 7 7 7 29.6 29.6 29.6 33.01 7.065E-92 35061000 20676000 14385000 3980 IPI:IPI00298946.1 Down syndrome critical region protein 3;Down syndrome critical region protein A DSCR3;DCRA;DSCRA O14972 ENST00000309117 1 0.72775 1.5197 0.79892 0.999 1.0185 1.0632 DnaJ;Pkinase;PTEN_C2 adherens junction;cell junction;cell-substrate adherens junction;cell-substrate junction;focal adhesion;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane part;membrane-bounded organelle;organelle ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cell cycle;cellular biopolymer metabolic process;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process 15 15 15 16.9 16.9 16.9 143.19 1.3302E-115 189300000 100340000 88959000 3981 IPI:IPI00298949.1 Cyclin G-associated kinase GAK O14976 ENST00000314167 K08855 1 0.81747 1.6497 0.82361 1.0741 1.0649 1.0977 CRM1_C;IBN_N;Xpo1 annulate lamellae;Cajal body;cytosol;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nuclear body;nuclear pore;nucleolus;organelle;protein complex;ribonucleoprotein complex binding;nucleic acid binding;protein binding;RNA binding anatomical structure formation;cellular component assembly;cellular component organization;cellular process;nucleobase, nucleoside, nucleotide and nucleic acid transport;protein complex assembly;protein import into nucleus, docking;transport 40 40 40 43.8 43.8 43.8 123.38 0 2542100000 1336400000 1205700000 3982 IPI:IPI00298961.3 Exportin-1;Chromosome region maintenance 1 protein homolog XPO1;CRM1 O14980 ENST00000195419;ENST00000403576;ENST00000405115;ENST00000406957 1 0.77078 1.318 0.79034 1.0012 0.87328 1.0342 13 13 13 13.4 13.4 13.4 136.51 9.8273E-153 75260000 41790000 33470000 3983 IPI:IPI00298991.9;IPI:IPI00164930.5;IPI:REV_IPI00070643.6;IPI:IPI00167881.6;IPI:REV_IPI00219265.3 UPF0681 protein KIAA1033 KIAA1033 Q2M389-1;Q2M389;Q2M389-2 ENST00000311317;ENST00000332180 5 0.91977 1.7768 0.91476 1.1909 1.1865 1.2009 FERM_M;FERM_N;I_LWEQ;Talin_middle;VBS adherens junction;cell junction;cell projection membrane;cell-cell junction;cell-substrate adherens junction;cell-substrate junction;cytoplasm;cytoskeleton;focal adhesion;leading edge membrane;membrane-bounded organelle;organelle;ruffle membrane actin binding;binding;cytoskeletal protein binding;LIM domain binding;protein binding;protein domain specific binding;structural constituent of cytoskeleton;structural molecule activity;vinculin binding anatomical structure formation;cell motion;cell-cell junction assembly;cellular component assembly;cellular component organization;cellular process;cytoskeletal anchoring at plasma membrane;cytoskeleton organization;organelle organization Focal adhesion 89 89 82 49.2 49.2 45.6 269.76 0 6326000000 3230300000 3095700000 3984 IPI:IPI00298994.6 Talin-1 TLN1;KIAA1027;TLN Q9Y490 ENST00000314888 K06271 1 0.72892 1.3292 0.71804 0.96586 0.86524 0.92737 Peptidase_M24 cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;ribonucleoprotein complex binding;DNA binding;nucleic acid binding;protein binding;RNA binding;transcription factor activity;transcription regulator activity cell cycle arrest;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;regulation of translation;RNA processing;rRNA processing;transcription 24 24 24 55.1 55.1 55.1 43.786 0 7454200000 3971200000 3482900000 3985 IPI:IPI00299000.5 Proliferation-associated protein 2G4;Cell cycle protein p38-2G4 homolog;ErbB3-binding protein 1 PA2G4;EBP1 Q9UQ80 ENST00000303305 1 0.57319 1.4327 0.69075 0.7825 0.9169 0.92993 Arm;IBB cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;organelle part;pore complex;protein complex binding;nuclear localization sequence binding;peptide binding;protein binding;protein transporter activity;signal sequence binding;substrate-specific transporter activity;transporter activity anatomical structure formation;intracellular protein transport;NLS-bearing substrate import into nucleus;nucleocytoplasmic transport;protein complex assembly;protein import into nucleus;protein targeting;protein transport;transport 11 7 7 29 21.3 21.3 57.81 3.8024E-164 215660000 120020000 95637000 3986 IPI:IPI00299033.1 Importin subunit alpha-3;Karyopherin subunit alpha-3;SRP1-gamma;Importin alpha Q2 KPNA3;QIP2 O00505 ENST00000261667 1 0.70719 1.4881 0.6564 0.96228 0.93185 0.79524 CH;IQ;RasGAP;RasGAP_C actin cytoskeleton;cell part;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle actin binding;binding;calmodulin binding;cytoskeletal protein binding;enzyme activator activity;enzyme inhibitor activity;GTPase activator activity;GTPase inhibitor activity;protein binding;Ras GTPase activator activity;small GTPase regulator activity cell communication;cellular process;intracellular signaling cascade;regulation of biological process;regulation of cell communication;regulation of signal transduction;signal transduction;small GTPase mediated signal transduction Regulation of actin cytoskeleton 13 11 11 10.2 9.2 9.2 180.61 1.6279E-33 55791000 30797000 24993000 3987 IPI:IPI00299048.6;IPI:IPI00871809.3 Ras GTPase-activating-like protein IQGAP2 IQGAP2 Q13576-1;Q13576 ENST00000274364;ENST00000396236 K05767 2 1.0307 1.9666 1.0335 1.3008 1.3365 1.2692 SAM_2 integral to endoplasmic reticulum membrane;integral to membrane;integral to organelle membrane;integral to plasma membrane;intrinsic to endoplasmic reticulum membrane;intrinsic to membrane;intrinsic to organelle membrane;intrinsic to plasma membrane binding;calcium ion binding;cation binding;ion binding;metal ion binding;protein binding calcium ion transport;cation transport;detection of calcium ion;detection of chemical stimulus;di-, tri-valent inorganic cation transport;ion transport;regulation of metal ion transport;response to inorganic substance;response to metal ion;transport 13 13 13 25.1 25.1 25.1 77.422 3.8309E-112 152240000 68592000 83653000 3988 IPI:IPI00299063.2 Stromal interaction molecule 1 STIM1;GOK Q13586 ENST00000300737 1 0.91634 1.8436 1.0086 1.3037 1.2161 1.3241 LIM cell part;cytoplasm;intracellular part binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding anatomical structure formation;biological adhesion;cell adhesion;cell communication;cellular component assembly;cellular component organization;cellular process;macromolecular complex subunit organization;protein complex assembly;signal transduction 11 11 11 33.4 33.4 33.4 43.332 3.7858E-180 484880000 255100000 229780000 3989 IPI:IPI00299066.5 Leupaxin LPXN;LDLP O60711 ENST00000263845 1 0.87591 1.4722 0.8459 1.0759 1.0495 1.1145 UPF0121 cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intrinsic to membrane;melanosome;membrane-bounded organelle;membrane-bounded vesicle;organelle;vesicle binding;protein binding 8 8 8 32.4 32.4 32.4 27.978 7.9142E-124 813890000 432750000 381150000 3990 IPI:IPI00299084.1 Transmembrane protein 33;Protein DB83 TMEM33;DB83 P57088 ENST00000264452 1 1.0777 2.0421 1.0586 1.4198 1.3366 1.412 PDZ adherens junction;cell junction;cell-substrate adherens junction;cell-substrate junction;cytoplasmic membrane-bounded vesicle;cytoskeleton;cytosol;endoplasmic reticulum membrane;focal adhesion;interleukin-5 receptor complex;membrane;nucleus binding;cytokine receptor binding;cytoskeletal adaptor activity;cytoskeletal protein binding;interleukin-5 receptor binding;protein binding;protein dimerization activity;protein heterodimerization activity;receptor binding;syndecan binding cell communication;cell-cell signaling;cytoskeleton organization;intracellular protein transport;organelle organization;protein targeting;protein targeting to membrane;substrate-bound cell migration, cell extension;synaptic transmission;transport 5 5 5 27.5 27.5 27.5 32.444 8.7045E-112 154320000 86125000 68199000 3991 IPI:IPI00299086.3;IPI:IPI00479018.2;IPI:IPI00478874.1 Syntenin-1;Syndecan-binding protein 1;Melanoma differentiation-associated protein 9;Scaffold protein Pbp1;Pro-TGF-alpha cytoplasmic domain-interacting protein 18 SDCBP;MDA9;SYCL O00560-1;O00560;O00560-2;O00560-3 ENST00000260130 3 0.8961 1.679 0.92682 1.1718 1.1415 1.2432 PX;Sorting_nexin;Vps5 cell part;cytoplasm;intracellular part binding;lipid binding;phosphoinositide binding;phospholipid binding;protein binding;protein transporter activity;substrate-specific transporter activity;transporter activity cell communication;cellular component organization;cellular process;endocytosis;establishment of protein localization;intracellular protein transport;membrane invagination;membrane organization;protein transport;transport;vesicle-mediated transport 18 18 16 37.6 37.6 33.5 58.47 1.1551E-250 987410000 495240000 492170000 3992 IPI:IPI00299095.2 Sorting nexin-2;Transformation-related gene 9 protein SNX2;TRG9 O60749 ENST00000379516 1 0.83559 1.6916 0.85166 1.0362 1.1145 1.1119 Proteasome;Proteasome_A_N cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;proteasome core complex;protein complex binding;catalytic activity;endopeptidase activity;hydrolase activity;identical protein binding;peptidase activity;peptidase activity, acting on L-amino acid peptides;protein binding;threonine-type endopeptidase activity;threonine-type peptidase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Proteasome 11 11 11 55.9 55.9 55.9 29.483 0 2921100000 1484100000 1437000000 3994 IPI:IPI00299155.5 Proteasome subunit alpha type-4;Proteasome component C9;Macropain subunit C9;Multicatalytic endopeptidase complex subunit C9;Proteasome subunit L PSMA4;PSC9 P25789 ENST00000044462 K02728 1 NaN 1.5296 0.85544 NaN 1.0501 1.057 PDZ cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial membrane;mitochondrial outer membrane;mitochondrial part;organelle membrane;organelle outer membrane;organelle part;outer membrane binding;protein binding 3 3 3 25.5 25.5 25.5 15.928 2.1801E-05 17891000 10352000 7539200 3995 IPI:IPI00299193.1 Synaptojanin-2-binding protein;Mitochondrial outer membrane protein 25 SYNJ2BP;OMP25 P57105 ENST00000256366 1 0.69428 1.1906 0.61135 0.90936 0.80121 0.81971 TK cell part;cytoplasmic part;cytosol;intracellular part ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;purine nucleotide binding;thymidine kinase activity;transferase activity;transferase activity, transferring phosphorus-containing groups biosynthetic process;cellular process;DNA metabolic process;DNA replication;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Drug metabolism - other enzymes;Pyrimidine metabolism 8 8 8 37.2 37.2 37.2 25.468 1.6815E-52 38377000 20755000 17623000 3996 IPI:IPI00299214.7 Thymidine kinase, cytosolic TK1 P04183 ENST00000301634;ENST00000405273 K00857 1 0.71527 1.4371 0.74671 0.97162 0.92964 0.96924 GTP_EFTU;GTP_EFTU_D2 cell part;cytoplasm;intracellular part binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;nucleic acid binding;nucleotide binding;protein binding;pyrophosphatase activity;translation factor activity, nucleic acid binding;translation initiation factor activity biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;regulation of biosynthetic process;regulation of gene expression;regulation of translation;regulation of translational initiation;translation 27 27 27 25.9 25.9 25.9 138.83 0 1293100000 692340000 600770000 3997 IPI:IPI00299254.4 Eukaryotic translation initiation factor 5B;Translation initiation factor IF-2 EIF5B;IF2;KIAA0741 O60841 ENST00000289371 K03243 1 0.75343 1.4155 0.74941 1.0208 0.88798 1.085 ArfGap cytoplasmic part;cytosol;Golgi apparatus part;Golgi membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;nucleus;organelle;organelle membrane;organelle part ARF GTPase activator activity;binding;enzyme activator activity;enzyme regulator activity;GTPase activator activity;protein transporter activity;small GTPase regulator activity;substrate-specific transporter activity;transporter activity;zinc ion binding cellular process;intracellular protein transport;protein secretion;protein transport;regulation of ARF GTPase activity;regulation of GTPase activity;regulation of Ras GTPase activity;secretion by cell;transport;vesicle-mediated transport 9 9 9 28.7 28.7 28.7 56.928 5.2311E-48 86285000 45324000 40962000 3998 IPI:IPI00299263.5 ADP-ribosylation factor GTPase-activating protein 3 ARFGAP3;ARFGAP1 Q9NP61 ENST00000263245 1 0.99778 1.9162 0.92837 1.3313 1.2539 1.2565 HSP70 cell fraction;cell part;cytoplasmic part;endoplasmic reticulum;insoluble fraction;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane fraction;membrane-bounded organelle;microsome;organelle;vesicular fraction adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding 6 6 6 16.6 16.6 16.6 51.927 9.8163E-13 104790000 41953000 62838000 3999 IPI:IPI00299299.3 Heat shock 70 kDa protein 13;Stress 70 protein chaperone microsome-associated 60 kDa protein;Microsomal stress 70 protein ATPase core HSPA13;STCH P48723 ENST00000285667 K09491 1 0.96338 1.5357 NaN 1.1955 1.09 NaN Biotin_carb_C;Biotin_lipoyl;CPSase_L_chain;CPSase_L_D2;HMGL-like;PYC_OADA cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part ATP binding;binding;biotin binding;catalytic activity;ligase activity;ligase activity, forming carbon-carbon bonds;nucleoside binding;nucleotide binding;purine nucleoside binding;purine nucleotide binding;pyruvate carboxylase activity;vitamin binding alcohol metabolic process;carbohydrate metabolic process;gluconeogenesis;glucose metabolic process;lipid metabolic process;metabolic process;monosaccharide metabolic process;organic acid metabolic process;pyruvate metabolic process Alanine and aspartate metabolism;Citrate cycle (TCA cycle);Pyruvate metabolism 5 5 5 4.8 4.8 4.8 129.63 1.4875E-09 6745600 3803900 2941700 4000 IPI:IPI00299402.1 Pyruvate carboxylase, mitochondrial;Pyruvic carboxylase PC P11498 ENST00000355677;ENST00000393955;ENST00000393958;ENST00000393960 K01959;K01960 1 0.80353 1.5515 0.73589 1.1233 0.98385 1.0508 Ets;SAM_PNT cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;protein binding;RNA polymerase II transcription factor activity;transcription coactivator activity;transcription cofactor activity;transcription factor activity;transcription factor binding biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent 6 6 6 12.1 12.1 12.1 51.295 4.195E-34 77157000 40850000 36308000 4002 IPI:IPI00299413.1 GA-binding protein alpha chain;Transcription factor E4TF1-60;Nuclear respiratory factor 2 subunit alpha GABPA;E4TF1A Q06546 ENST00000354828;ENST00000400075 K09441 1 0.63646 1.3868 0.71307 0.85571 0.93014 0.94022 FimP cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle cell differentiation;cellular developmental process;cellular process;developmental process 11 11 11 17.1 17.1 17.1 78.507 1.0835E-110 250230000 131890000 118340000 4003 IPI:IPI00299417.4 THO complex subunit 5 homolog;NF2/meningioma region protein pK1.3;Placental protein 39.2 THOC5;C22orf19;KIAA0983 Q13769 ENST00000358079;ENST00000397871;ENST00000397872;ENST00000397873 1 0.94112 1.994 1.0383 1.3791 1.211 1.3354 7 7 7 32.1 32.1 32.1 34.592 7.5339E-96 221250000 108270000 112990000 4004 IPI:IPI00299465.8 Leucine zipper transcription factor-like protein 1 LZTFL1 Q9NQ48 ENST00000296135 1 0.2218 0.82825 0.27532 0.31265 0.51582 0.39177 FA_desaturase cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part binding;catalytic activity;iron ion binding;oxidoreductase activity;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;stearoyl-CoA 9-desaturase activity biosynthetic process;cellular process;fatty acid biosynthetic process;fatty acid metabolic process;lipid biosynthetic process;lipid metabolic process;metabolic process;organic acid biosynthetic process;organic acid metabolic process Biosynthesis of unsaturated fatty acids;PPAR signaling pathway 2 2 2 5.3 5.3 5.3 41.522 2.4603E-17 20144000 12535000 7609300 4005 IPI:IPI00299468.3 Acyl-CoA desaturase;Stearoyl-CoA desaturase;Fatty acid desaturase;Delta(9)-desaturase SCD O00767 ENST00000370355 K00507 1 0.67346 1.1851 0.66884 0.85783 0.78519 0.88581 Barren condensin complex;cytoplasm;cytoskeleton;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle cell cycle process;cell division;cellular component organization;cellular process;chromosome condensation;chromosome organization;DNA packaging;mitotic chromosome condensation;organelle organization Cell cycle - yeast 14 14 14 23.2 23.2 23.2 82.562 9.864E-87 443050000 223100000 219950000 4006 IPI:IPI00299507.6 Condensin complex subunit 2;Non-SMC condensin I complex subunit H;Barren homolog protein 1;Chromosome-associated protein H;XCAP-H homolog NCAPH;BRRN;BRRN1;CAPH;KIAA0074 Q15003 ENST00000240423 K06676 1 0.74072 1.3618 0.69537 0.9788 0.92213 0.88769 BRISC complex;cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex binding;polyubiquitin binding;protein binding;small conjugating protein binding;ubiquitin binding 5 5 5 15.2 15.2 15.2 46.9 8.2524E-59 42256000 23115000 19141000 4007 IPI:IPI00299517.3 BRISC complex subunit Abro1;Abraxas brother protein 1;Protein FAM175B FAM175B;ABRO1;KIAA0157 Q15018 ENST00000298492 1 0.63485 1.1186 0.64872 0.78279 0.75584 0.8256 chromosomal part;condensin core heterodimer;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;organelle part;protein complex binding;histone binding;protein binding cell cycle process;cell division;cellular component organization;cellular process;chromosome condensation;chromosome organization;DNA packaging;mitotic chromosome condensation;organelle organization 32 32 32 28.8 28.8 28.8 157.18 0 927070000 505710000 421370000 4008 IPI:IPI00299524.2;IPI:REV_IPI00219005.3 Condensin complex subunit 1;Non-SMC condensin I complex subunit D2;Chromosome condensation-related SMC-associated protein 1;Chromosome-associated protein D2;XCAP-D2 homolog NCAPD2;CAPD2;CNAP1;KIAA0159 Q15021 ENST00000315579 2 0.89804 1.2627 0.60038 1.1234 0.86466 0.93636 VEFS-Box cell part;ESC/E(Z) complex;histone methyltransferase complex;intracellular organelle part;intracellular part;macromolecular complex;methyltransferase complex;nuclear part;nucleoplasm part;organelle part;PcG protein complex;protein complex binding;catalytic activity;cation binding;histone methyltransferase activity;ion binding;methyltransferase activity;protein methyltransferase activity;transferase activity;transferase activity, transferring one-carbon groups;zinc ion binding biosynthetic process;chromatin organization;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;regulation of transcription, DNA-dependent;transcription 5 5 5 8.9 8.9 8.9 83.054 3.2592E-31 58595000 30290000 28304000 4009 IPI:IPI00299526.7 Polycomb protein SUZ12;Suppressor of zeste 12 protein homolog;Joined to JAZF1 protein;Chromatin precipitated E2F target 9 protein SUZ12;CHET9;JJAZ1;KIAA0160 Q15022 ENST00000322652 K11463 1 0.61487 1.2593 0.51024 0.83352 0.80215 0.65189 FHA;Kinesin cytoplasm;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;microtubule;non-membrane-bounded organelle;nucleus;organelle;organelle part;spindle ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;microtubule motor activity;motor activity;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity cellular process;microtubule-based movement;microtubule-based process 7 7 7 4.6 4.6 4.6 186.49 3.5525E-54 36980000 19562000 17417000 4011 IPI:IPI00299554.3 Kinesin-like protein KIF14 KIF14;KIAA0042 Q15058 ENST00000367350 K10392 1 1.0577 2.1717 1.1115 1.352 1.4635 1.4524 Thioredoxin cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;endoplasmic reticulum;endoplasmic reticulum lumen;ER-Golgi intermediate compartment;melanosome;membrane-bounded organelle;membrane-bounded vesicle;membrane-enclosed lumen;organelle;vesicle binding;catalytic activity;intramolecular oxidoreductase activity;intramolecular oxidoreductase activity, interconverting keto- and enol-groups;isomerase activity;protein binding;protein disulfide isomerase activity biopolymer metabolic process;cellular biopolymer metabolic process;cellular homeostasis;cellular metabolic process;cellular process;homeostatic process;macromolecule metabolic process;metabolic process;protein folding;protein metabolic process 16 16 16 39.4 39.4 39.4 53.9 0 2857000000 1399700000 1457400000 4012 IPI:IPI00299571.5;IPI:IPI00644989.2 Protein disulfide-isomerase A6;Protein disulfide isomerase P5;Thioredoxin domain-containing protein 7 PDIA6;TXNDC7 Q15084-2;Q15084;Q15084-1 ENST00000272227;ENST00000381611 K09584 2 0.68671 1.384 0.69309 0.88683 0.92175 0.90433 Ribosomal_L7Ae cell fraction;cytosolic large ribosomal subunit;insoluble fraction;large ribosomal subunit;macromolecular complex;membrane fraction;non-membrane-bounded organelle;organelle;polysomal ribosome;ribonucleoprotein complex;ribosomal subunit;ribosome binding;nucleic acid binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;ribonucleoprotein complex biogenesis;translational elongation Ribosome 17 17 17 47.7 47.7 47.7 29.995 0 10825000000 5713400000 5112000000 4013 IPI:IPI00299573.12 60S ribosomal protein L7a;Surfeit locus protein 3;PLA-X polypeptide RPL7A;SURF-3;SURF3 P62424 ENST00000323345 K02936 1 0.8152 1.6953 0.8011 1.0623 1.1074 1.0565 PC_rep cell part;cytoplasmic part;cytosol;intracellular part;macromolecular complex;proteasome regulatory particle;protein complex binding;enzyme regulator activity;protein binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;proteasomal protein catabolic process;proteolysis;regulation of catabolic process;regulation of metabolic process;ubiquitin-dependent protein catabolic process Proteasome 32 32 32 45.6 45.6 45.6 105.84 0 1761500000 944540000 816960000 4014 IPI:IPI00299608.3;IPI:IPI00456695.1 26S proteasome non-ATPase regulatory subunit 1;26S proteasome regulatory subunit RPN2;26S proteasome regulatory subunit S1;26S proteasome subunit p112 PSMD1 Q99460-1;Q99460;Q99460-2 ENST00000308696;ENST00000373635 K03032 2 0.74496 1.6098 0.64276 1.0013 1.0293 0.81075 PI3_PI4_kinase;PI3K_C2;PI3Ka cell part;cytoplasmic part;cytosolic part;intracellular part;macromolecular complex;phosphoinositide 3-kinase complex;protein complex 1-phosphatidylinositol-3-kinase activity;ATP binding;binding;catalytic activity;inositol or phosphatidylinositol kinase activity;kinase activity;lipid kinase activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding cell communication;cellular process;glycerophospholipid metabolic process;intracellular signaling cascade;lipid metabolic process;metabolic process;phosphate metabolic process;phospholipid metabolic process;phosphorus metabolic process;signal transduction Inositol phosphate metabolism;Phosphatidylinositol signaling system;Regulation of autophagy 6 6 6 6.9 6.9 6.9 101.55 1.1162E-37 35253000 20668000 14585000 4015 IPI:IPI00299755.2 Phosphatidylinositol 3-kinase catalytic subunit type 3;Phosphoinositide-3-kinase class 3;Phosphatidylinositol 3-kinase p100 subunit PIK3C3 Q8NEB9 ENST00000262039;ENST00000398870 K00914 1 0.81067 1.2836 0.7332 0.97441 0.93666 0.91566 C1_1;CH;PH;RhoGEF;SH2;SH3_1;SH3_2 cell part;intracellular binding;GTPase activator activity;guanyl-nucleotide exchange factor activity;Ras guanyl-nucleotide exchange factor activity;Rho guanyl-nucleotide exchange factor activity;SH3/SH2 adaptor activity;signal transducer activity;small GTPase regulator activity cell communication;cellular process;intracellular signaling cascade;regulation of cell communication;regulation of Rho protein signal transduction;regulation of signal transduction;signal transduction;small GTPase mediated signal transduction 3 2 2 3.9 2.7 2.7 97.775 3.5152E-32 266690000 145660000 121040000 4016 IPI:IPI00299763.1;IPI:IPI00219689.1 Guanine nucleotide exchange factor VAV3 VAV3 Q9UKW4-1;Q9UKW4;Q9UKW4-2 ENST00000343258;ENST00000370056 2 NaN 1.1296 0.53723 NaN 0.65686 0.78507 MTS binding;catalytic activity;methyltransferase activity;nucleic acid binding;transferase activity;transferase activity, transferring one-carbon groups cellular metabolic process;cellular process;metabolic process;methylation;one-carbon metabolic process 4 4 4 19.6 19.6 19.6 23.719 4.4523E-19 57659000 31626000 26033000 4017 IPI:IPI00299888.1 Methyltransferase-like protein 5 METTL5;DC3;HSPC133 Q9NRN9 ENST00000260953;ENST00000392640;ENST00000409965;ENST00000410097 1 0.69705 1.2543 0.68489 0.89904 0.85159 0.88315 MCM cell part;chromatin;chromosomal part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;MCM complex;nuclear chromosome part;nuclear part;nucleoplasm part;organelle part;protein complex adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding DNA metabolic process;DNA replication initiation;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;response to stress;transcription Cell cycle;Cell cycle - yeast;DNA replication 44 44 44 61.9 61.9 61.9 81.307 0 5099400000 2640600000 2458800000 4018 IPI:IPI00299904.3;IPI:IPI00219740.3 DNA replication licensing factor MCM7;CDC47 homolog;P1.1-MCM3 MCM7;CDC47;MCM2 P33993-1;P33993 ENST00000303887;ENST00000343023 K02210 2 0.85562 1.821 0.74945 1.144 1.1491 0.97437 Ocnus cell part;cytoplasmic part;cytosol;intracellular part catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;phosphatase activity;phosphohistidine phosphatase activity;phosphoprotein phosphatase activity;phosphoric ester hydrolase activity cellular metabolic process;cellular process;dephosphorylation;metabolic process;phosphate metabolic process;phosphorus metabolic process 3 3 3 39.2 39.2 39.2 13.832 3.1997E-16 133950000 71699000 62248000 4019 IPI:IPI00299977.1 14 kDa phosphohistidine phosphatase;Phosphohistidine phosphatase 1;Protein janus-A homolog PHPT1;PHP14;CGI-202;HSPC141 Q9NRX4 ENST00000247665;ENST00000371659 1 0.92236 1.4404 0.8481 1.163 1.0025 1.1575 WD40 6 6 6 10.1 10.1 10.1 73.2 1.2313E-36 69038000 35860000 33178000 4020 IPI:IPI00300060.4;IPI:IPI00903186.1;IPI:IPI00847446.1 WD repeat-containing protein 70 WDR70 Q9NW82 ENST00000265107 3 0.64453 1.2221 0.62123 0.82898 0.81499 0.80206 B3_4;B5 cell fraction;cell part;cytoplasm;intracellular part;soluble fraction aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;ligase activity;magnesium ion binding;nucleic acid binding;nucleoside binding;nucleotide binding;phenylalanine-tRNA ligase activity;purine nucleoside binding;RNA binding cellular amino acid and derivative metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;phenylalanyl-tRNA aminoacylation;tRNA aminoacylation for protein translation;tRNA metabolic process Aminoacyl-tRNA biosynthesis;Phenylalanine, tyrosine and tryptophan biosynthesis 31 31 30 51.4 51.4 50.4 66.129 4.4891E-265 2542000000 1405100000 1137000000 4021 IPI:IPI00300074.3 Phenylalanyl-tRNA synthetase beta chain;Phenylalanine--tRNA ligase beta chain FARSB;FARSLB;FRSB;HSPC173 Q9NSD9 ENST00000281828 K01890 1 0.46874 1.0141 0.47048 0.59935 0.64859 0.62938 PWP2;WD40 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part catalytic activity;endopeptidase activity;hydrolase activity;molecular transducer activity;peptidase activity;serine hydrolase activity;serine-type endopeptidase activity;serine-type peptidase activity;signal transducer activity biopolymer metabolic process;catabolic process;cell communication;cellular process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;protein catabolic process;protein metabolic process;proteolysis;signal transduction 13 13 13 16.9 16.9 16.9 102.45 1.1974E-164 248760000 137690000 111070000 4022 IPI:IPI00300078.6 Periodic tryptophan protein 2 homolog PWP2;PWP2H Q15269 ENST00000291576 1 1.0318 1.7153 0.92744 1.2505 1.1714 1.1375 QRPTase_C;QRPTase_N cell part;cytoplasmic part;cytosol;intracellular part binding;catalytic activity;identical protein binding;nicotinate-nucleotide diphosphorylase (carboxylating) activity;protein binding;transferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring pentosyl groups coenzyme metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;organic acid metabolic process;oxidoreduction coenzyme metabolic process;protein complex assembly Nicotinate and nicotinamide metabolism 4 4 4 13.8 13.8 13.8 30.815 6.5129E-19 91968000 47488000 44479000 4023 IPI:IPI00300086.3 Nicotinate-nucleotide pyrophosphorylase [carboxylating];Quinolinate phosphoribosyltransferase [decarboxylating] QPRT Q15274 ENST00000219771;ENST00000395384 K00767 1 0.8886 1.6209 0.992 1.1772 1.0845 1.2163 MMR_HSR1 Cajal body;cytoplasmic part;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;nuclear body;nuclear part;organelle;organelle part binding;catalytic activity;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;hydrolase activity;nucleotide binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding establishment of localization;establishment of localization in cell;establishment of protein localization;intracellular transport;nuclear export;nuclear transport;nucleocytoplasmic transport;protein transport;transport 18 18 18 31.6 31.6 31.6 75.225 5.457E-57 243740000 122740000 120990000 4024 IPI:IPI00300094.6 Large subunit GTPase 1 homolog LSG1 Q9H089 ENST00000265245 1 1.2673 1.5697 0.94411 1.6162 1.0199 1.2318 Ras cell projection membrane;clathrin-coated vesicle;coated pit;coated vesicle;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;endocytic vesicle;intracellular organelle;melanosome;membrane-bounded organelle;membrane-bounded vesicle;organelle;vesicle binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;lipid binding;nucleotide binding;phosphatidylinositol-4,5-bisphosphate binding;phospholipid binding;pyrophosphatase activity cell communication;cellular process;cytokinesis;endosome transport;establishment of protein localization;intracellular signaling cascade;protein transport;signal transduction;small GTPase mediated signal transduction;transport;vesicle-mediated transport 8 7 7 47.3 41.8 41.8 23.025 1.5256E-71 187540000 88950000 98591000 4025 IPI:IPI00300096.4 Ras-related protein Rab-35;Rab-1C;GTP-binding protein RAY RAB35;RAB1C;RAY Q15286 ENST00000229340 K07876 1 0.61348 1.153 0.63908 0.79544 0.79677 0.80604 DUF1726;DUF699 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part acetyltransferase activity;acyltransferase activity;ATP binding;binding;catalytic activity;N-acetyltransferase activity;N-acyltransferase activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;transferase activity metabolic process 38 38 38 47.8 47.8 47.8 115.7 0 2003500000 1093100000 910380000 4026 IPI:IPI00300127.3 N-acetyltransferase 10 NAT10;ALP;KIAA1709 Q9H0A0 ENST00000257829 1 0.64539 1.4366 0.63568 0.8867 0.96802 0.84674 Arc32 cell part;intracellular organelle part;intracellular part;macromolecular complex;mediator complex;nuclear part;nucleoplasm part;organelle part;protein complex general RNA polymerase II transcription factor activity;RNA polymerase II transcription factor activity;RNA polymerase II transcription mediator activity;transcription regulator activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;proteolysis;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 2 2 2 11 11 11 32.818 6.0696E-50 14374000 8147100 6227200 4027 IPI:IPI00300278.3;IPI:IPI00419516.1;IPI:IPI00418130.1 Mediator of RNA polymerase II transcription subunit 8;Mediator complex subunit 8;Activator-recruited cofactor 32 kDa component MED8 Q96G25-2;Q96G25;Q96G25-1;Q96G25-3 ENST00000290663;ENST00000372457 3 0.74393 1.7128 0.90213 0.99757 1.1177 1.1352 SPC22 cell fraction;insoluble fraction;integral to membrane;intracellular part;intrinsic to membrane;macromolecular complex;membrane fraction;membrane part;microsome;organelle part;protein complex;signal peptidase complex;vesicular fraction catalytic activity;hydrolase activity;peptidase activity biopolymer metabolic process;cellular biopolymer metabolic process;cellular process;macromolecule metabolic process;metabolic process;peptide metabolic process;protein metabolic process;protein processing;signal peptide processing Biotin metabolism;Lysine degradation 4 4 4 18.9 18.9 18.9 20.313 5.199E-36 225710000 120620000 105090000 4028 IPI:IPI00300299.6 Signal peptidase complex subunit 3;Microsomal signal peptidase 23 kDa subunit;SPase 22 kDa subunit;SPC22/23 SPCS3;SPC22;UNQ1841/PRO3567 P61009 ENST00000264597 K01423 1 0.78331 1.5349 0.76207 1.0141 1.0581 1.0803 Paf1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 8 8 8 18.1 18.1 18.1 59.975 2.2997E-59 201480000 96919000 104560000 4029 IPI:IPI00300333.4;IPI:IPI00384593.3 RNA polymerase II-associated factor 1 homolog;Pancreatic differentiation protein 2 PAF1;PD2 Q8N7H5-1;Q8N7H5;Q8N7H5-2 ENST00000221265 2 0.8105 1.4283 0.76843 1.0181 0.93716 0.98496 Skp1_POZ cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;protein binding nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;proteolysis;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription;ubiquitin-dependent protein catabolic process Pathways in cancer;Renal cell carcinoma;Ubiquitin mediated proteolysis 4 4 4 49.1 49.1 49.1 12.473 3.4392E-156 339770000 180440000 159330000 4030 IPI:IPI00300341.5 Transcription elongation factor B polypeptide 1;RNA polymerase II transcription factor SIII subunit C;SIII p15;Elongin 15 kDa subunit;Elongin-C TCEB1 Q15369 ENST00000284811 K03872 1 0.76922 1.4848 0.75684 0.99066 0.99842 1.0046 CPSF_A cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;small nuclear ribonucleoprotein complex;spliceosomal complex binding;catalytic activity;nucleic acid binding;protein binding;RNA splicing factor activity, transesterification mechanism nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 41 41 40 37.7 37.7 37.7 135.58 0 3757400000 2040700000 1716800000 4031 IPI:IPI00300371.5;IPI:IPI00828110.1;IPI:IPI00179138.3 Splicing factor 3B subunit 3;Spliceosome-associated protein 130;Pre-mRNA-splicing factor SF3b 130 kDa subunit;STAF130 SF3B3;KIAA0017;SAP130 Q15393-1;Q15393 ENST00000302516;ENST00000310750 3 NaN 3.415 1.3033 NaN 2.1884 1.6098 Transglut_C;Transglut_core;Transglut_N extrinsic to internal side of plasma membrane;extrinsic to membrane;extrinsic to plasma membrane;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane part;membrane-bounded organelle;nucleus;organelle acyltransferase activity;binding;calcium ion binding;catalytic activity;GTP binding;GTPase activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein-glutamine gamma-glutamyltransferase activity;purine nucleoside binding anatomical structure formation;anatomical structure morphogenesis;cellular component organization;cellular process;epidermal cell differentiation;metabolic process;peptide cross-linking;protein complex assembly;protein modification process 7 7 7 11.4 11.4 11.4 76.631 8.88E-49 7730000 3168700 4561400 4032 IPI:IPI00300376.5 Protein-glutamine gamma-glutamyltransferase E;Transglutaminase-3;Protein-glutamine gamma-glutamyltransferase E 50 kDa non-catalytic chain;Protein-glutamine gamma-glutamyltransferase E 27 kDa catalytic chain TGM3 Q08188 ENST00000381458 K05620 1 0.73893 1.3152 0.76781 0.936 0.91912 0.98956 CutC cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;copper ion binding;ion binding;metal ion binding;transition metal ion binding cation transport;chemical homeostasis;copper ion transport;di-, tri-valent inorganic cation homeostasis;establishment of localization;homeostatic process;ion homeostasis;ion transport;metal ion transport;transition metal ion transport;transport 2 2 2 12.1 12.1 12.1 29.341 2.7338E-112 48742000 25108000 23634000 4033 IPI:IPI00300408.3 Copper homeostasis protein cutC homolog CUTC;CGI-32 Q9NTM9 ENST00000370476 K06201 1 0.67764 1.5084 0.64482 0.91223 0.9594 0.86309 MIF4G;Upf2 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle;perinuclear region of cytoplasm binding;identical protein binding;nucleic acid binding;protein binding;RNA binding mRNA catabolic process;nuclear-transcribed mRNA catabolic process;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA catabolic process;RNA export from nucleus 15 15 15 13.8 13.8 13.8 147.81 3.7987E-155 81284000 45754000 35530000 4034 IPI:IPI00300504.5;IPI:IPI00472081.2 Regulator of nonsense transcripts 2;Nonsense mRNA reducing factor 2;Up-frameshift suppressor 2 homolog UPF2;KIAA1408;RENT2 Q9HAU5-1;Q9HAU5;Q9HAU5-2 ENST00000313977;ENST00000313999;ENST00000356352;ENST00000357604 2 NaN 1.5125 NaN NaN 1.003 NaN A_deaminase AMP deaminase activity;catalytic activity;deaminase activity;hydrolase activity;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines AMP catabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;purine base metabolic process;purine nucleotide biosynthetic process;purine nucleotide catabolic process;purine nucleotide metabolic process Purine metabolism 5 5 5 6.8 6.8 6.8 89.727 4.2471E-13 9479200 5010500 4468600 4035 IPI:IPI00411384.2;IPI:IPI00300573.2;IPI:IPI00941882.1 AMP deaminase 3;AMP deaminase isoform E;Erythrocyte AMP deaminase AMPD3 Q01432-2;Q01432;Q01432-1;Q01432-3 ENST00000256183;ENST00000396553;ENST00000396554 K01490 3 0.64726 1.399 0.61854 0.85312 0.85237 0.86496 RRM_1;SAP cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;double-stranded DNA binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding;structure-specific DNA binding biosynthetic process;chromatin organization;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;regulation of transcription, DNA-dependent;transcription 13 13 7 21 21 13.1 102.64 1.8974E-194 875770000 478580000 397190000 4037 IPI:IPI00300631.3 Scaffold attachment factor B1;SAB-B1;SAF-B;HSP27 estrogen response element-TATA box-binding protein SAFB;HAP;HET;SAFB1 Q15424 ENST00000292123 1 0.86989 1.4338 0.8 1.1064 0.93575 1.058 CDC73 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding biosynthetic process;cell cycle;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription 17 17 17 29.4 29.4 29.4 60.576 2.3557E-71 382900000 172910000 209990000 4038 IPI:IPI00300659.4 Parafibromin;Cell division cycle protein 73 homolog;Hyperparathyroidism 2 protein CDC73;C1orf28;HRPT2 Q6P1J9 ENST00000367435 1 0.67449 1.2601 0.65149 0.86793 0.83325 0.80819 zf-C3HC4 cell part;cytoplasmic part;endosomal part;endosome membrane;intracellular organelle part;intracellular part;late endosome membrane;lysosomal membrane;membrane;organelle membrane;organelle part;vacuolar membrane;vacuolar part binding;cation binding;ion binding;metal ion binding;nucleotide binding;protein binding;transition metal ion binding;zinc ion binding establishment of localization;establishment of protein localization;protein transport;transport 19 19 19 22.4 22.4 22.4 107.84 1.0657E-93 147680000 80958000 66727000 4039 IPI:IPI00300697.1;IPI:REV_IPI00184848.5 Vacuolar protein sorting-associated protein 11 homolog;RING finger protein 108 VPS11;RNF108;PP3476 Q9H270 ENST00000300793 2 0.46864 NaN NaN 0.65796 NaN NaN Pkinase cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups cell cycle;intracellular protein transport;nucleocytoplasmic transport;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein export from nucleus;protein modification process;protein targeting;transport mTOR signaling pathway 2 2 2 5.1 5.1 5.1 48.368 0.00019124 7038700 6057600 981190 4040 IPI:IPI00300700.4;IPI:IPI00456673.4;IPI:IPI00396083.3 STE20-related kinase adapter protein alpha;STE20-related adapter protein;Serologically defined breast cancer antigen NY-BR-96 STRADA;LYK5;STRAD Q7RTN6-1;Q7RTN6;Q7RTN6-3;Q7RTN6-2 ENST00000336174;ENST00000392950 K08271 3 0.82996 1.369 0.83207 1.1505 0.87974 1.1777 binding;protein binding 2 2 2 11.6 11.6 11.6 26.524 2.4197E-20 264570000 131800000 132770000 4041 IPI:IPI00719040.1;IPI:IPI00300990.5 Uncharacterized protein C1orf77 C1orf77;HT031;PP7704 Q9Y3Y2-3;Q9Y3Y2;Q9Y3Y2-1 ENST00000368694;ENST00000392618 2 0.89101 1.7791 0.87915 1.1809 1.1678 1.1479 TRAP_alpha cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part binding;calcium ion binding;cation binding;ion binding;metal ion binding;peptide binding;signal sequence binding cotranslational protein targeting to membrane;intracellular protein transport;positive regulation of cell proliferation;protein targeting;protein targeting to membrane;protein transport;regulation of cell proliferation;transport 3 3 3 11.9 11.9 11.9 32.235 3.0836E-64 399800000 204860000 194940000 4042 IPI:IPI00301021.3;IPI:IPI00449669.2 Translocon-associated protein subunit alpha;Signal sequence receptor subunit alpha SSR1;TRAPA;PSEC0262 P43307-1;P43307;P43307-2 ENST00000244763;ENST00000379928;ENST00000397511 2 0.6736 1.3721 0.67964 0.90668 0.90381 0.88761 NHL biological regulation;cell redox homeostasis;cellular homeostasis;cellular process;homeostatic process;regulation of biological process;regulation of biological quality;regulation of cellular process 5 5 5 7.3 7.3 7.3 79.443 2.9357E-33 30435000 17144000 13291000 4043 IPI:IPI00301051.3;IPI:IPI00878166.1 NHL repeat-containing protein 2 NHLRC2 Q8NBF2-1;Q8NBF2;Q8NBF2-2 ENST00000369301 2 0.94808 1.6486 1.197 1.2191 1.1368 1.5166 VASP_tetra;WH1 actin cytoskeleton;adherens junction;cell junction;cell projection membrane;cell-substrate adherens junction;cell-substrate junction;cytoplasm;cytoskeleton;filopodium membrane;focal adhesion;lamellipodium membrane;leading edge membrane;organelle actin binding;binding;cytoskeletal protein binding;protein binding;protein domain specific binding;SH3 domain binding Focal adhesion;Leukocyte transendothelial migration 11 11 11 30.3 30.3 30.3 39.829 2.3318E-102 368990000 167270000 201730000 4044 IPI:IPI00301058.5 Vasodilator-stimulated phosphoprotein VASP P50552 ENST00000245932;ENST00000407001 K06274 1 0.6274 1.3394 0.59034 0.83638 0.90037 0.77012 IBN_N cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;organelle part;pore complex;protein complex binding;protein binding anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;protein complex assembly;protein import into nucleus, docking 6 6 6 7.6 7.6 7.6 112.53 3.9378E-91 16079000 7606000 8473300 4045 IPI:IPI00301107.7 Importin-11;Ran-binding protein 11 IPO11;RANBP11 Q9UI26 ENST00000325324;ENST00000409296 1 0.68773 1.596 0.75642 0.97719 1.0232 1.0265 Pyrophosphatase cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;inorganic diphosphatase activity;magnesium ion binding;pyrophosphatase activity cellular metabolic process;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process Oxidative phosphorylation 13 13 13 44.4 44.4 44.4 39.638 1.6683E-212 361110000 198600000 162510000 4046 IPI:IPI00470502.2;IPI:IPI00301109.4;IPI:IPI00470503.2;IPI:IPI00470504.2 Inorganic pyrophosphatase 2, mitochondrial;Pyrophosphatase SID6-306 PPA2;HSPC124 Q9H2U2-2;Q9H2U2;Q9H2U2-1;Q9H2U2-3 ENST00000310267;ENST00000341695;ENST00000348706;ENST00000354147;ENST00000357415 K01507 4 0.7555 1.6659 0.84629 0.98571 1.0633 1.1359 DUF2364 cell part;intracellular organelle part;intracellular part;macromolecular complex;mediator complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex binding;protein binding;receptor activity;receptor binding;RNA polymerase II transcription factor activity;signal transducer activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding cell communication;intracellular signaling cascade;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;signal transduction;transcription initiation;transcription initiation from RNA polymerase II promoter 8 8 8 14.6 14.6 14.6 72.875 2.4962E-67 41918000 21946000 19972000 4047 IPI:IPI00301139.5;IPI:IPI00855753.1 Mediator of RNA polymerase II transcription subunit 17;Mediator complex subunit 17;Cofactor required for Sp1 transcriptional activation subunit 6;CRSP complex subunit 6;Transcriptional coactivator CRSP77;Vitamin D3 receptor-interacting protein complex 80 kDa component;Thyroid hormone receptor-associated protein complex 80 kDa component;Activator-recruited cofactor 77 kDa component MED17;ARC77;CRSP6;DRIP77;DRIP80;TRAP80 Q9NVC6-1;Q9NVC6 ENST00000251871 2 0.57067 1.5432 0.74313 0.70296 1.0024 0.98244 SCP cell part;extracellular region;integral to membrane;intrinsic to membrane;membrane part endopeptidase inhibitor activity;enzyme inhibitor activity;enzyme regulator activity;peptidase inhibitor activity 3 3 3 8.4 8.4 8.4 49.471 2.2476E-12 39068000 21959000 17109000 4048 IPI:IPI00301143.5;IPI:IPI00845506.1 Peptidase inhibitor 16;Cysteine-rich secretory protein 9;PSP94-binding protein PI16;CRISP9;PSPBP;PSEC0164;UNQ289/PRO328 Q6UXB8-1;Q6UXB8;Q6UXB8-2 ENST00000373674 2 NaN NaN 0.9542 NaN NaN 1.2324 DUF323 endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;membrane-enclosed lumen;organelle;organelle lumen;organelle part binding;calcium ion binding;catalytic activity;cation binding;ion binding;metal ion binding;oxidoreductase activity amine metabolic process;aminoglycan metabolic process;carbohydrate metabolic process;glycosaminoglycan metabolic process;macromolecule metabolic process;metabolic process;nitrogen compound metabolic process;polysaccharide metabolic process 2 2 2 5.9 5.9 5.9 46.856 0.0013578 3285400 1613100 1672300 4049 IPI:IPI00432718.2;IPI:IPI00301144.7;IPI:IPI00332413.3 Sulfatase-modifying factor 1;C-alpha-formylglycine-generating enzyme 1 SUMF1;FGE;PSEC0152;UNQ3037/PRO9852 Q8NBK3-3;Q8NBK3;Q8NBK3-1;Q8NBK3-2 ENST00000272902;ENST00000405420 3 0.75495 1.8556 0.86209 1.0543 1.2048 1.1659 DUF821 endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;membrane-enclosed lumen;organelle;organelle lumen;organelle part 8 8 8 22.7 22.7 22.7 46.189 1.3456E-45 44710000 23665000 21045000 4050 IPI:IPI00301163.1 KTEL motif-containing protein 1;CAP10-like 46 kDa protein;Myelodysplastic syndromes relative protein KTELC1;C3orf9;CLP46;MDSRP;MDS010;UNQ490/PRO1006 Q8NBL1 ENST00000295588 1 NaN NaN 0.89859 NaN NaN 1.2662 AA_permease cell part;integral to membrane;intrinsic to membrane;membrane part anion transmembrane transporter activity;binding;cation transmembrane transporter activity;ion transmembrane transporter activity;secondary active transmembrane transporter activity;solute:cation symporter activity;symporter activity;transporter activity anion transport;cation transport;cellular homeostasis;cellular ion homeostasis;cellular process;chloride transport;inorganic anion transport;ion transport;monovalent inorganic cation transport;potassium ion transport;sodium ion transport;transport 2 1 1 2.8 1.6 1.6 126.18 5.4448E-19 141550 68568 72984 4051 IPI:IPI00877110.1;IPI:IPI00301180.4 Solute carrier family 12 member 5;Electroneutral potassium-chloride cotransporter 2;Erythroid K-Cl cotransporter 2;Neuronal K-Cl cotransporter SLC12A5;KCC2;KIAA1176 Q9H2X9-1;Q9H2X9;Q9H2X9-2 ENST00000243964 2 0.62316 1.4329 0.6264 0.77561 0.97659 0.75721 adh_short binding;catalytic activity;oxidoreductase activity metabolic process;oxidation reduction 2 2 2 5.4 5.4 5.4 35.932 1.8238E-10 43627000 24362000 19265000 4052 IPI:IPI00301204.2 Retinol dehydrogenase 13 RDH13;PSEC0082;UNQ736/PRO1430 Q8NBN7 ENST00000291892 K11161 1 0.7147 1.8555 0.73477 0.90484 1.1026 0.94358 cell part;intracellular enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity;Rab GTPase activator activity;Ras GTPase activator activity;small GTPase regulator activity biological regulation;regulation of catalytic activity;regulation of GTPase activity;regulation of hydrolase activity;regulation of molecular function;regulation of Rab GTPase activity;regulation of Ras GTPase activity 6 6 6 29.5 29.5 29.5 32.171 2.1597E-22 39300000 21181000 18120000 4053 IPI:IPI00301216.6 TBC1 domain family member 13 TBC1D13 Q9NVG8 ENST00000223865;ENST00000372648 1 0.48569 0.96054 0.47879 0.61536 0.64093 0.61779 Amidohydro_1;CPSase_L_chain;CPSase_L_D2;CPSase_L_D3;CPSase_sm_chain;GATase;MGS;OTCace;OTCace_N cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;nuclear matrix;nuclear part;organelle part aspartate carbamoyltransferase activity;carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity;carbamoyl-phosphate synthase activity;catalytic activity;dihydroorotase activity;nucleoside binding;nucleotide binding;purine nucleoside binding 'de novo' pyrimidine base biosynthetic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;pyrimidine base metabolic process;pyrimidine nucleotide metabolic process Alanine and aspartate metabolism;Glutamate metabolism;Pyrimidine metabolism 42 42 42 25.6 25.6 25.6 242.98 0 1522500000 854730000 667800000 4054 IPI:IPI00301263.2 CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase CAD P27708 ENST00000264705 K11540 1 0.80724 1.6967 0.85871 1.0427 1.1414 1.0531 DUF1625 endoplasmic reticulum;Golgi apparatus;integral to membrane;intracellular organelle;intrinsic to membrane;membrane;membrane-bounded organelle;nuclear inner membrane;nuclear membrane;organelle;organelle inner membrane;organelle membrane 12 12 12 43.5 43.5 43.5 44.875 3.2009E-162 440130000 229910000 210220000 4055 IPI:IPI00301280.2 Transmembrane protein 43;Protein LUMA TMEM43;UNQ2564/PRO6244 Q9BTV4 ENST00000306077 1 0.51513 1.0795 0.62191 0.68406 0.71411 0.78042 F-box;WD40 cell part;cytoplasm;intracellular part;macromolecular complex;protein complex;ubiquitin ligase complex acid-amino acid ligase activity;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;protein binding;small conjugating protein ligase activity;ubiquitin-protein ligase activity catabolic process;cell communication;cell surface receptor linked signal transduction;cellular process;macromolecule catabolic process;metabolic process;protein modification process;proteolysis;signal transduction;Wnt receptor signaling pathway Hedgehog signaling pathway;Ubiquitin mediated proteolysis;Wnt signaling pathway 9 9 5 17.2 17.2 9.2 62.09 1.2528E-68 68669000 38185000 30484000 4056 IPI:IPI00328796.4;IPI:IPI00301283.1;IPI:IPI00306671.2;IPI:IPI00307418.5 F-box/WD repeat-containing protein 11;F-box/WD repeat-containing protein 1B;F-box and WD repeats protein beta-TrCP2;Homologous to Slimb protein FBXW11;BTRCP2;FBW1B;FBXW1B;KIAA0696 Q9UKB1-1;Q9UKB1;Q9UKB1-3;Q9UKB1-2 ENST00000265094;ENST00000296933;ENST00000393802;ENST00000393804 K03362 4 0.68841 1.3666 0.69012 0.90177 0.9131 0.89623 DEAD;Helicase_C ATP binding;ATP-dependent helicase activity;ATP-dependent RNA helicase activity;binding;catalytic activity;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;RNA binding;RNA helicase activity Folate biosynthesis 14 14 14 29 29 29 75.406 1.5377E-232 1046100000 548170000 497940000 4057 IPI:IPI00301323.1 ATP-dependent RNA helicase DDX18;DEAD box protein 18;Myc-regulated DEAD box protein DDX18 Q9NVP1 ENST00000263239 K01529 1 NaN 1.4535 0.6278 NaN 0.89394 0.91527 RNA_pol_Rpb2_1;RNA_pol_Rpb2_2;RNA_pol_Rpb2_3;RNA_pol_Rpb2_4;RNA_pol_Rpb2_5;RNA_pol_Rpb2_6;RNA_pol_Rpb2_7 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;DNA binding;DNA-directed RNA polymerase activity;nucleic acid binding;nucleoside binding;nucleotidyltransferase activity;transferase activity;transferase activity, transferring phosphorus-containing groups;zinc ion binding biosynthetic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription 5 5 5 5.7 5.7 5.7 127.78 1.2139E-46 37245000 20855000 16390000 4058 IPI:IPI00301346.3 DNA-directed RNA polymerase III subunit RPC2;DNA-directed RNA polymerase III subunit B;DNA-directed RNA polymerase III 127.6 kDa polypeptide;C128 POLR3B Q9NW08 ENST00000228347 1 0.65249 1.436 0.71422 0.9119 0.87383 0.9163 Skp1;Skp1_POZ cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;protein binding catabolic process;cell cycle process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Cell cycle;Cell cycle - yeast;TGF-beta signaling pathway;Ubiquitin mediated proteolysis;Wnt signaling pathway 9 9 9 39.3 39.3 39.3 18.658 1.1873E-99 561990000 304260000 257730000 4059 IPI:IPI00301364.3;IPI:IPI00172421.7 S-phase kinase-associated protein 1;Cyclin A/CDK2-associated protein p19;p19skp1;p19A;RNA polymerase II elongation factor-like protein;Organ of Corti protein 2;OCP-II;Transcription elongation factor B SKP1;EMC19;OCP2;SKP1A;TCEB1L P63208-1;P63208;P63208-2 ENST00000328392;ENST00000353411 K03094 2 0.8605 1.6399 0.76769 1.0486 1.1699 0.91725 Peptidase_S10 binding;carboxypeptidase activity;catalytic activity;exopeptidase activity;hydrolase activity;peptidase activity;protein binding;serine hydrolase activity;serine-type carboxypeptidase activity;serine-type peptidase activity biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis 5 5 5 12.4 12.4 12.4 54.163 6.8111E-07 89287000 48362000 40925000 4060 IPI:IPI00301395.4 Probable serine carboxypeptidase CPVL;Carboxypeptidase, vitellogenic-like;Vitellogenic carboxypeptidase-like protein;HVLP CPVL;VLP;PSEC0124;UNQ197/PRO223 Q9H3G5 ENST00000265394;ENST00000396276;ENST00000409850 K09645 1 0.48039 1.1166 NaN 0.64234 0.70521 NaN PCI cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex;signalosome 2 2 2 9.5 9.5 9.5 30.276 9.4845E-12 7482800 3920100 3562600 4061 IPI:IPI00301419.2 COP9 signalosome complex subunit 7a;JAB1-containing signalosome subunit 7a;Dermal papilla-derived protein 10 COPS7A;CSN7A;DERP10 Q9UBW8 ENST00000229251 K12180 1 0.86587 1.4742 1.1295 1.0631 1.0522 1.4304 zf-C3HC cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;enzyme binding;ion binding;kinase binding;metal ion binding;protein binding;protein kinase binding;transition metal ion binding;zinc ion binding catabolic process;cellular component organization;cellular process;macromolecule catabolic process;metabolic process;mitosis;modification-dependent protein catabolic process;nuclear division;organelle organization;protein metabolic process;proteolysis 3 3 3 8.8 8.8 8.8 55.261 2.9294E-52 18783000 9412200 9371000 4062 IPI:IPI00301421.5;IPI:IPI00339382.3;IPI:IPI00479595.3 Nuclear-interacting partner of ALK;Nuclear-interacting partner of anaplastic lymphoma kinase;Zinc finger C3HC-type protein 1 ZC3HC1;NIPA;HSPC216 Q86WB0-1;Q86WB0;Q86WB0-2;Q86WB0-3 ENST00000311873;ENST00000358303;ENST00000360708 3 0.92864 1.4781 0.79848 1.1636 1.0229 1.0133 URO-D cell part;cytoplasm;intracellular part carbon-carbon lyase activity;carboxy-lyase activity;catalytic activity;lyase activity;uroporphyrinogen decarboxylase activity biosynthetic process;cellular process;heme biosynthetic process;heterocycle biosynthetic process;metabolic process;nitrogen compound metabolic process;porphyrin biosynthetic process;porphyrin metabolic process;tetrapyrrole metabolic process Porphyrin and chlorophyll metabolism 11 11 11 40.6 40.6 40.6 40.786 9.1271E-133 321740000 167390000 154350000 4063 IPI:IPI00301489.3 Uroporphyrinogen decarboxylase UROD P06132 ENST00000246337 K01599 1 0.70099 1.5205 0.71777 0.9503 0.999 0.9696 RRM_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;nucleic acid binding;nucleotide binding;protein binding;RNA binding;RNA splicing factor activity, transesterification mechanism nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 14 14 13 35.1 35.1 32.3 33.665 2.4894E-217 1350900000 700110000 650840000 4064 IPI:IPI00301503.8;IPI:IPI00927500.1 Transformer-2 protein homolog beta;Transformer-2 protein homolog B;Splicing factor, arginine/serine-rich 10 TRA2B;SFRS10 P62995-1;P62995;P62995-3 ENST00000259043;ENST00000342294;ENST00000392502 2 1.0382 1.7907 1.0784 1.3784 1.2025 1.4318 Mob1_phocein binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding Cell cycle - yeast 7 7 1 29.2 29.2 3.2 25.079 4.6646E-39 630920000 319410000 311510000 4065 IPI:IPI00301518.6;IPI:IPI00386961.3 Mps one binder kinase activator-like 1B;Mob1 homolog 1B;Mob1 alpha;Protein Mob4B MOBKL1B;C2orf6;MOB4B;MOBK1B Q9H8S9-1;Q9H8S9;Q9H8S9-2 ENST00000377668;ENST00000409969 K06685 2 0.53615 0.97236 0.50304 0.67986 0.63422 0.64701 Pkinase;RCC1 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;nucleus;organelle ATP binding;binding;catalytic activity;kinase activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cellular component organization;cellular process;metabolic process;mitosis;nuclear division;organelle organization;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein modification process 14 14 14 17.6 17.6 17.6 107.17 2.2621E-125 424900000 232700000 192190000 4067 IPI:IPI00301609.8;IPI:REV_IPI00220994.3 Serine/threonine-protein kinase Nek9;Never in mitosis A-related kinase 9;Nercc1 kinase;NIMA-related kinase 8 NEK9;KIAA1995;NEK8;NERCC Q8TD19 ENST00000238616 K08857 2 0.62693 1.4058 0.45149 0.81133 0.9298 0.62305 DUF814;FbpA cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 4 4 4 4.6 4.6 4.6 122.95 8.705E-130 49226000 29053000 20172000 4068 IPI:IPI00301618.7 Serologically defined colon cancer antigen 1;Antigen NY-CO-1 SDCCAG1 O60524-1;O60524 ENST00000298310;ENST00000382135 1 NaN NaN 0.92822 NaN NaN 1.1668 Torsin cell part;cytoplasmic part;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;'de novo' protein folding;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 3 3 3 7.1 7.1 7.1 46.198 3.5203E-09 40017000 19938000 20079000 4069 IPI:IPI00301631.5;IPI:IPI00386008.3;IPI:IPI00737378.1 Torsin-3A;Torsin family 3 member A;ATP-dependent interferon-responsive protein TOR3A;ADIR Q9H497-1;Q9H497;Q9H497-2 ENST00000352445;ENST00000367627 3 0.77019 1.2324 0.86866 1.0268 0.75409 1.079 GLE1 cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;organelle part;pore complex;protein complex binding;protein binding cellular process;intracellular protein transport;mRNA export from nucleus;nucleobase, nucleoside, nucleotide and nucleic acid transport;nucleocytoplasmic transport;poly(A)+ mRNA export from nucleus;protein transport;RNA export from nucleus;transport 5 5 5 10.2 10.2 10.2 79.835 6.9768E-78 20533000 8126800 12406000 4070 IPI:IPI00301647.4;IPI:IPI00411438.1 Nucleoporin GLE1;GLE1-like protein GLE1;GLE1L Q53GS7-1;Q53GS7;Q53GS7-2 ENST00000309971;ENST00000372770 2 NaN 1.1703 0.60276 NaN 0.81619 0.75024 NTP_transf_2;PAP_assoc cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;DNA binding;DNA polymerase activity;DNA-directed DNA polymerase activity;nucleic acid binding;nucleotidyltransferase activity;transferase activity;transferase activity, transferring phosphorus-containing groups biosynthetic process;DNA metabolic process;DNA replication;metabolic process;mitosis;nitrogen compound metabolic process;nuclear division;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization 3 3 3 6.6 6.6 6.6 70.806 8.9721E-21 8189900 4475700 3714300 4072 IPI:IPI00301922.3;IPI:IPI00940660.1;IPI:IPI00383794.3;IPI:IPI00550722.5 PAP-associated domain-containing protein 5;Topoisomerase-related function protein 4-2 PAPD5 Q8NDF8-1;Q8NDF8;Q8NDF8-3;Q8NDF8-2;Q8NDF8-4 ENST00000357464 4 NaN 0.88429 0.55002 NaN 0.61979 0.68461 Pkinase cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription elongation factor complex binding;catalytic activity;cyclin-dependent protein kinase activity;DNA binding;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;RNA elongation;transcription initiation;transcription initiation from RNA polymerase II promoter 9 8 8 15.7 14.1 14.1 53.365 1.9352E-80 47018000 25418000 21600000 4073 IPI:IPI00552413.2;IPI:IPI00301923.4 Cell division protein kinase 9;Cyclin-dependent kinase 9;Serine/threonine-protein kinase PITALRE;Cell division cycle 2-like protein kinase 4 CDK9;CDC2L4 P50750-2;P50750;P50750-1 ENST00000373264;ENST00000373265 K02211 2 0.63735 1.2797 0.63022 0.86937 0.87677 0.85359 5 5 5 6.7 6.7 6.7 98.583 7.3099E-13 21887000 12779000 9108200 4074 IPI:IPI00301987.6;IPI:IPI00889558.1 WD repeat-containing protein mio MIOS Q9NXC5-1;Q9NXC5;Q9NXC5-2 ENST00000340080;ENST00000405785 2 0.70862 1.4593 NaN 0.95521 0.94225 NaN FAA_hydrolase binding;calcium ion binding;catalytic activity;cation binding;hydrolase activity;ion binding;magnesium ion binding;metal ion binding metabolic process 6 6 2 38.5 38.5 13.4 34.613 8.3385E-70 20538000 10509000 10029000 4075 IPI:IPI00301994.6 Fumarylacetoacetate hydrolase domain-containing protein 2B FAHD2B Q6P2I3 ENST00000272610 1 0.67635 1.4187 0.69048 0.91627 0.88522 0.92187 Gar1 Cajal body;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nuclear body;nucleolus;organelle;organelle part;ribonucleoprotein complex;small nucleolar ribonucleoprotein complex binding;cation channel activity;cation transmembrane transporter activity;channel activity;ion channel activity;ion transmembrane transporter activity;nucleic acid binding;RNA binding;rRNA binding;transporter activity cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 9 9 9 33.2 33.2 33.2 22.348 3.3854E-126 444120000 231430000 212680000 4077 IPI:IPI00302176.5;IPI:IPI00607820.1 H/ACA ribonucleoprotein complex subunit 1;snoRNP protein GAR1;Nucleolar protein family A member 1 GAR1;NOLA1 Q9NY12-1;Q9NY12;Q9NY12-2 ENST00000226796;ENST00000394631 K11128 2 0.60654 1.1389 0.58427 0.78145 0.72689 0.73911 TRAUB adherens junction;cell junction;cell-substrate adherens junction;cell-substrate junction;centrosome;focal adhesion;intracellular organelle;microtubule organizing center;non-membrane-bounded organelle;nucleolus;organelle binding;DNA binding;nucleic acid binding;protein binding;transcription factor activity;transcription regulator activity anti-apoptosis;negative regulation of apoptosis;negative regulation of biological process;negative regulation of programmed cell death;regulation of apoptosis;regulation of cell death;regulation of programmed cell death 10 10 10 24.1 24.1 24.1 63.132 1.1461E-65 72189000 37593000 34597000 4078 IPI:IPI00302238.3 Protein AATF;Apoptosis-antagonizing transcription factor;Rb-binding protein Che-1 AATF;CHE1;DED;HSPC277 Q9NY61 ENST00000225402 1 0.4904 0.88598 0.50308 0.64148 0.58042 0.65141 DEAD;Helicase_C cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part ATP binding;ATP-dependent RNA helicase activity;binding;catalytic activity;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;RNA binding;RNA helicase activity cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing Folate biosynthesis 17 17 17 41 41 41 61.589 9.9095E-174 455580000 245210000 210370000 4079 IPI:IPI00302281.1;IPI:IPI00883989.1 Probable ATP-dependent RNA helicase DDX56;DEAD box protein 56;ATP-dependent 61 kDa nucleolar RNA helicase;DEAD-box protein 21 DDX56;DDX21;NOH61 Q9NY93 ENST00000258772 K01529 2 NaN 1.2525 NaN NaN 0.81415 NaN IQ;Myosin_head;Myosin_N;Myosin_tail_1 cytoplasmic part;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;muscle myosin complex;myosin complex;myosin filament;myosin II complex;organelle part;protein complex;striated muscle thick filament actin binding;ATP binding;binding;calmodulin binding;catalytic activity;cytoskeletal protein binding;motor activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;structural molecule activity multicellular organismal process;muscle contraction;muscle system process;striated muscle contraction;system process Tight junction 3 1 1 1.6 0.8 0.8 222.76 5.6009E-05 364450 204840 159610 4080 IPI:IPI00302329.1 Myosin-8;Myosin heavy chain 8;Myosin heavy chain, skeletal muscle, perinatal MYH8 P13535 ENST00000252173;ENST00000403437 K10352 1 0.73001 1.6622 0.84552 1.0104 1.0541 1.1899 Hydrolase catalytic activity metabolic process 2 2 2 12.7 12.7 12.7 25.249 2.372E-06 36158000 19383000 16775000 4081 IPI:IPI00302436.6 Haloacid dehalogenase-like hydrolase domain-containing protein 1A;Protein GS1 HDHD1A;DXF68S1E;FAM16AX;GS1 Q08623 ENST00000381077 1 0.79423 1.6711 0.87641 1.0327 1.1191 1.0766 IBN_N cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;organelle part;pore complex;protein complex binding;nuclear export signal receptor activity;protein binding;protein transporter activity;substrate-specific transporter activity;transporter activity anatomical structure formation;cellular process;intracellular protein transport;nucleocytoplasmic transport;protein complex assembly;protein export from nucleus;protein import into nucleus, docking;protein targeting;protein transport;transport 20 20 20 23.4 23.4 23.4 123.91 2.1347E-243 279280000 154810000 124480000 4082 IPI:IPI00302458.10;IPI:IPI00009645.1 Exportin-7;Ran-binding protein 16 XPO7;KIAA0745;RANBP16 Q9UIA9 ENST00000252512 2 0.7677 1.4396 0.73428 0.98822 0.96533 0.94443 CH;Filamin actin cytoskeleton;cell cortex;cytoskeleton;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;membrane;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle;plasma membrane actin binding;binding;cytoskeletal protein binding;enzyme binding;glycoprotein binding;protein binding;Ral GTPase binding;Ras GTPase binding;receptor binding;Rho GTPase binding;signal transducer activity;small GTPase binding;transcription factor binding actin filament organization;cell communication;cell surface receptor linked signal transduction;cytoskeleton organization;organelle organization;regulation of nucleotide metabolic process;signal transduction Focal adhesion;MAPK signaling pathway 73 69 69 37.6 36.2 36.2 280.74 0 3184900000 1754600000 1430300000 4083 IPI:IPI00333541.6;IPI:IPI00302592.2 Filamin-A;Alpha-filamin;Filamin-1;Endothelial actin-binding protein;Actin-binding protein 280;Non-muscle filamin FLNA;FLN;FLN1 P21333-1;P21333;P21333-2 ENST00000369850;ENST00000369863 K04437 2 0.87051 1.656 1.0468 1.1102 1.1844 1.2833 Cation_efflux cell part;cytoplasmic part;Golgi apparatus;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane part;membrane-bounded organelle;organelle binding;cation transmembrane transporter activity;ion transmembrane transporter activity;protein binding;substrate-specific transmembrane transporter activity;transmembrane transporter activity;transporter activity;zinc ion binding cation transport;establishment of localization;ion transport;metal ion transport;transition metal ion transport;transport;zinc ion transport 3 3 3 9 9 9 41.625 9.7089E-103 16917000 8909700 8007600 4084 IPI:IPI00302605.3 Zinc transporter 7;Znt-like transporter 2;Solute carrier family 30 member 7 SLC30A7;ZNT7;ZNTL2 Q8NEW0 ENST00000357650;ENST00000370112 1 0.68747 1.3245 0.6904 0.84502 0.90333 0.91497 C2 cell part;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;DNA binding;molecular transducer activity;nucleic acid binding;signal transducer activity biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 13 13 13 17.6 17.6 17.6 104.06 1.042E-114 66587000 36614000 29973000 4085 IPI:IPI00302647.4;IPI:IPI00759686.1;IPI:IPI00743836.1 Coiled-coil and C2 domain-containing protein 1A;Five repressor element under dual repression-binding protein 1;Putative NF-kappa-B-activating protein 023N CC2D1A Q6P1N0-1;Q6P1N0;Q6P1N0-2 ENST00000318003;ENST00000397486 3 0.67731 1.6496 0.6591 0.84678 1.1683 0.83494 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding;transcription regulator activity cellular process;regulation of biosynthetic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription initiation;transcription initiation from RNA polymerase II promoter 6 6 6 29.6 29.6 29.6 35.431 1.0625E-33 24298000 12795000 11504000 4086 IPI:IPI00302652.3;IPI:IPI00455649.3 Mediator of RNA polymerase II transcription subunit 27;Mediator complex subunit 27;Cofactor required for Sp1 transcriptional activation subunit 8;CRSP complex subunit 8;Transcriptional coactivator CRSP34;P37 TRAP/SMCC/PC2 subunit MED27;CRSP34;CRSP8 Q6P2C8-1;Q6P2C8;Q6P2C8-2 ENST00000292035;ENST00000372184 2 0.63637 1.1144 0.3698 0.82096 0.7052 0.47807 5 5 5 15.2 15.2 15.2 42.399 2.5693E-18 84452000 45098000 39353000 4087 IPI:IPI00302658.6;IPI:IPI00333632.2;IPI:IPI00333633.1;IPI:IPI00328634.1 HAUS augmin-like complex subunit 4 HAUS4;C14orf94 Q9H6D7-1;Q9H6D7;Q9H6D7-3;Q9H6D7-4 ENST00000206474;ENST00000397409;ENST00000404078;ENST00000406739 4 1.0635 1.8816 1.0622 1.3793 1.3201 1.4833 ATP11 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle anatomical structure formation;cellular component assembly;cellular component organization;macromolecular complex assembly;macromolecular complex subunit organization;protein complex assembly 6 6 6 25.6 25.6 25.6 36.436 1.5886E-124 75582000 38085000 37498000 4089 IPI:IPI00302673.3 ATP synthase mitochondrial F1 complex assembly factor 1;ATP11 homolog ATPAF1;ATP11 Q5TC12 ENST00000371937 K07555 1 0.8785 1.5526 1.006 1.0754 1.0797 1.1746 ECH catalytic activity metabolic process 9 9 9 37.5 37.5 37.5 33.698 2.0375E-128 170680000 97571000 73107000 4090 IPI:IPI00302688.7;IPI:IPI00550928.3 Enoyl-CoA hydratase domain-containing protein 1 ECHDC1 Q9NTX5-1;Q9NTX5;Q9NTX5-2 ENST00000207783;ENST00000368293;ENST00000368295 2 0.67868 1.8205 0.80061 0.89804 1.2009 0.98825 Actin cell part;cytoplasm;intracellular part 6 6 5 16.8 16.8 15.3 46.306 1.312E-92 29796000 16389000 13407000 4091 IPI:IPI00302690.5 Actin-related protein 10;hARP11 ACTR10;ACTR11;ARP11 Q9NZ32 ENST00000254286 1 0.55319 1.1811 0.55556 0.73308 0.76489 0.72084 RB_A;RB_B;Rb_C chromatin;chromatin remodeling complex;chromosomal part;intracellular organelle part;intracellular part;macromolecular complex;nuclear body;nuclear part;organelle part;PML body;protein complex;Rb-E2F complex;SWI/SNF complex;transcription factor complex binding;DNA binding;nucleic acid binding;protein binding;receptor binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor activity;transcription factor binding cell cycle checkpoint;M phase;negative regulation of transcription from RNA polymerase II promoter;regulation of cell growth;regulation of transcription of G1/S-phase of mitotic cell cycle Bladder cancer;Cell cycle;Chronic myeloid leukemia;Glioma;Melanoma;Non-small cell lung cancer;Pancreatic cancer;Pathways in cancer;Prostate cancer;Small cell lung cancer 16 16 16 20 20 20 106.16 1.2485E-118 398520000 222720000 175800000 4092 IPI:IPI00302829.5 Retinoblastoma-associated protein;pRb;pp110;p105-Rb RB1 P06400 ENST00000267163 K06618 1 0.77602 1.4655 0.75001 1.0575 0.94255 1.0221 Cation_ATPase_C;Cation_ATPase_N;E1-E2_ATPase;Hydrolase endoplasmic reticulum;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane part;membrane-bounded organelle;organelle;protein complex;sodium:potassium-exchanging ATPase complex ATP binding;binding;catalytic activity;cation transmembrane transporter activity;magnesium ion binding;nucleoside binding;nucleotide binding;purine nucleoside binding;sodium:potassium-exchanging ATPase activity;transporter activity ATP biosynthetic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;transport Cardiac muscle contraction 18 7 7 19.1 7.8 7.8 111.75 2.1539E-289 85348000 43312000 42036000 4093 IPI:IPI00302840.2 Sodium/potassium-transporting ATPase subunit alpha-3;Na(+)/K(+) ATPase alpha-3 subunit;Na(+)/K(+) ATPase alpha(III) subunit ATP1A3 P13637 ENST00000302102 K01539 1 0.79622 1.5313 0.79654 1.0334 1.0236 1.0126 LSM cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;ribonucleoprotein complex;small nuclear ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;protein binding;RNA binding anatomical structure formation;cellular component assembly;cellular component organization;cellular process;ribonucleoprotein complex assembly;ribonucleoprotein complex biogenesis;spliceosomal snRNP biogenesis;spliceosome assembly Systemic lupus erythematosus 5 5 5 54.6 54.6 54.6 13.281 1.7495E-209 2126800000 1112100000 1014800000 4094 IPI:IPI00302850.4 Small nuclear ribonucleoprotein Sm D1;snRNP core protein D1;Sm-D autoantigen SNRPD1 P62314 ENST00000300413;ENST00000402743 K11087 1 0.81948 1.746 0.7994 1.1309 1.0237 1.1717 ARID;RBB1NT cell part;chromatin;chromosomal part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;nucleus;organelle;organelle part binding;chromatin binding;DNA binding;nucleic acid binding chromatin assembly or disassembly;chromatin organization;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;regulation of transcription, DNA-dependent;transcription 3 3 3 3.1 3.1 3.1 147.81 7.0007E-17 9466300 5026100 4440200 4095 IPI:IPI00328828.5;IPI:IPI00302917.5;IPI:IPI00647647.2;IPI:IPI00647132.2 AT-rich interactive domain-containing protein 4B;ARID domain-containing protein 4B;Histone deacetylase complex subunit SAP180;180 kDa Sin3-associated polypeptide;Sin3-associated polypeptide p180;Retinoblastoma-binding protein 1-like 1;Breast cancer-associated antigen BRCAA1 ARID4B;BRCAA1;RBBP1L1;RBP1L1;SAP180 Q4LE39-1;Q4LE39;Q4LE39-2;Q4LE39-3 ENST00000264183;ENST00000349213;ENST00000366603;ENST00000391856 4 0.95533 1.7519 0.97949 1.2493 1.1672 1.2475 Cpn60_TCP1 cell part;cytoplasmic membrane-bounded vesicle;cytoplasmic part;cytoplasmic vesicle;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;melanosome;membrane-bounded organelle;membrane-bounded vesicle;organelle;vesicle adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 32 32 32 67.9 67.9 67.9 57.924 0 12547000000 6509800000 6036800000 4096 IPI:IPI00302927.6 T-complex protein 1 subunit delta;CCT-delta;Stimulator of TAR RNA-binding CCT4;CCTD;SRB P50991 ENST00000233836;ENST00000394440 K09496 1 0.62068 1.1662 0.45715 0.81359 0.79291 0.6053 WD40 3 3 3 4.8 4.8 4.8 83.359 6.3579E-36 7874500 4897800 2976700 4097 IPI:IPI00879760.1;IPI:IPI00302965.7;IPI:IPI00477281.3 WD repeat-containing protein 91 WDR91;HSPC049 A4D1P6-1;A4D1P6;A4D1P6-2;A4D1P6-3 ENST00000344400;ENST00000354475 3 0.78362 1.2049 NaN 1.0143 0.81892 NaN WD40 cell part;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 2 2 2 9.7 9.7 9.7 42.123 3.9123E-05 10704000 6014900 4688900 4098 IPI:IPI00302990.3 WD repeat-containing protein 55 WDR55 Q9H6Y2-1;Q9H6Y2 ENST00000358337;ENST00000403979 1 NaN 1.5902 NaN NaN 0.97599 NaN A_deaminase;A_deaminase_N cell part;cytoplasmic part;extracellular region part;extracellular space;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle binding;catalytic activity;deaminase activity;growth factor activity;hydrolase activity;protein binding;receptor binding nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process 2 2 2 4.1 4.1 4.1 58.933 0.00079506 8365100 4713400 3651700 4099 IPI:IPI00303071.4 Cat eye syndrome critical region protein 1 CECR1;IDGFL Q9NZK5 ENST00000262607;ENST00000399837;ENST00000399839 1 0.91296 1.9472 1.1027 1.2661 1.3226 1.5017 Borealin chromosomal part;chromosome, centromeric region;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nucleolus;organelle;organelle part;protein complex binding;protein binding cell cycle phase;cell cycle process;cell division;cellular component organization;cellular process;mitosis;nuclear division;organelle fission;organelle organization 5 5 5 24.3 24.3 24.3 31.323 5.5826E-98 86365000 41284000 45081000 4100 IPI:IPI00303099.2 Borealin;Dasra-B;hDasra-B;Cell division cycle-associated protein 8;Pluripotent embryonic stem cell-related gene 3 protein CDCA8;PESCRG3 Q53HL2 ENST00000327331;ENST00000373055 K11514 1 0.72953 1.1077 0.69866 0.94792 0.74513 0.9805 ubiquitin cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;membrane;membrane part;nuclear body;nuclear membrane;nuclear part;nuclear pore;nuclear speck;nucleoplasm part;organelle membrane;organelle part;protein complex binding;protein binding DNA metabolic process;DNA repair;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein modification process;proteolysis;response to DNA damage stimulus;response to stress 5 5 5 45.5 45.5 45.5 11.557 1.6625E-34 763010000 388670000 374340000 4101 IPI:IPI00303105.3 Small ubiquitin-related modifier 1;Sentrin;Ubiquitin-like protein SMT3C;SMT3 homolog 3;Ubiquitin-homology domain protein PIC1;Ubiquitin-like protein UBL1;GAP-modifying protein 1 SUMO1;SMT3C;SMT3H3;UBL1;OK/SW-cl.43 P63165 ENST00000264281;ENST00000392245;ENST00000392246;ENST00000409368 K12160 1 0.88551 1.9 0.95606 1.2332 1.2169 1.2384 CTP_transf_3 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle catalytic activity;cytidylyltransferase activity;N-acylneuraminate cytidylyltransferase activity;nucleotidyltransferase activity;transferase activity;transferase activity, transferring phosphorus-containing groups biosynthetic process;carbohydrate metabolic process;lipid biosynthetic process;lipid metabolic process;lipopolysaccharide metabolic process;metabolic process;polysaccharide biosynthetic process;polysaccharide metabolic process Aminosugars metabolism 9 9 9 24.4 24.4 24.4 48.379 3.2087E-107 287390000 152280000 135120000 4102 IPI:IPI00303158.3;IPI:IPI00479958.1 N-acylneuraminate cytidylyltransferase;CMP-N-acetylneuraminic acid synthetase CMAS Q8NFW8-1;Q8NFW8;Q8NFW8-2 ENST00000229329 K00983 2 0.57827 1.0989 0.56187 0.76543 0.70511 0.74046 ABC_tran;Fer4;RLI cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle ATP binding;binding;catalytic activity;electron carrier activity;enzyme inhibitor activity;hydrolase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity;ribonuclease inhibitor activity catabolic process;macromolecule catabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to biotic stimulus;response to virus;RNA catabolic process 33 33 33 64.4 64.4 64.4 67.314 0 2937100000 1635900000 1301300000 4104 IPI:IPI00303207.3 ATP-binding cassette sub-family E member 1;RNase L inhibitor;Ribonuclease 4 inhibitor;2'-5'-oligoadenylate-binding protein;HuHP68 ABCE1;RLI;RNASEL1;RNASELI;RNS4I;OK/SW-cl.40 P61221 ENST00000296577 K06174 1 0.23905 0.57737 0.24473 0.28709 0.41544 0.29579 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;microbody;organelle;peroxisome catalytic activity;endopeptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides;serine hydrolase activity;serine-type endopeptidase activity;serine-type peptidase activity biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis 2 2 2 5.5 5.5 5.5 59.308 7.8772E-37 3905300 2140500 1764800 4105 IPI:IPI00303214.5;IPI:IPI00384482.5 Peroxisomal leader peptide-processing protease;Trypsin domain-containing protein 1;Peroxisomal leader peptide-processing protease, 10 kDa form;Peroxisomal leader peptide-processing protease, 49 kDa form TYSND1 Q2T9J0-1;Q2T9J0;Q2T9J0-2 ENST00000287078;ENST00000335494 2 0.62915 1.2927 0.72754 0.82197 0.87807 0.94796 Guanylate_kin;L27;PDZ;SH3_2 binding;protein binding anatomical structure formation;cellular component assembly;cellular component organization;macromolecular complex assembly;macromolecular complex subunit organization;protein complex assembly 2 2 2 4.3 4.3 4.3 61.116 1.484E-12 30525000 17486000 13039000 4106 IPI:IPI00303280.4 MAGUK p55 subfamily member 6;Veli-associated MAGUK 1 MPP6;VAM1 Q9NZW5 ENST00000222644;ENST00000396475;ENST00000409253 1 0.83637 1.3048 0.84028 1.1211 0.89129 1.0875 Arm;IBB cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;nucleoplasm;organelle part;pore complex;protein complex binding;nuclear localization sequence binding;peptide binding;protein binding;protein transporter activity;signal sequence binding;substrate-specific transporter activity;transporter activity intracellular protein transport;NLS-bearing substrate import into nucleus;nucleocytoplasmic transport;protein import;protein import into nucleus;protein targeting;protein transport;regulation of DNA recombination;transport 13 13 7 28.8 28.8 18.4 60.248 0 330020000 171410000 158610000 4107 IPI:IPI00303292.1 Importin subunit alpha-1;Karyopherin subunit alpha-1;SRP1-beta;RAG cohort protein 2;Nucleoprotein interactor 1 KPNA1;RCH2 P52294 ENST00000344337 1 0.89162 1.7824 0.92954 1.1383 1.2092 1.1668 DUF1394 16 16 14 54.6 54.6 47.8 36.748 0 989040000 520010000 469030000 4108 IPI:IPI00303318.2 Protein FAM49B;L1 FAM49B;BM-009 Q9NUQ9 ENST00000358017;ENST00000401979 1 0.84036 1.5495 0.85848 1.0936 1.0462 1.1501 RNA_GG_bind Cajal body;cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;nuclear body;nuclear part;nucleoplasm part;organelle part binding;nucleic acid binding;RNA binding cellular component biogenesis;cellular process;establishment of localization;establishment of protein localization;protein transport;ribonucleoprotein complex biogenesis;spliceosomal snRNP biogenesis;transport 4 4 4 11.7 11.7 11.7 44.402 8.4252E-17 128060000 66452000 61608000 4110 IPI:IPI00303402.7 Phosphorylated adapter RNA export protein;RNA U small nuclear RNA export adapter protein PHAX;RNUXA Q9H814 ENST00000297540 1 0.80327 1.5653 0.81111 1.0145 1.0529 1.0333 ATP-synt_ab;ATP-synt_ab_C;ATP-synt_ab_N cell surface;cytoplasmic part;intracellular part;macromolecular complex;membrane;membrane part;mitochondrial nucleoid;mitochondrial part;mitochondrial proton-transporting ATP synthase, catalytic core;nucleoid;organelle part;plasma membrane;protein complex ATP binding;binding;catalytic activity;cation transmembrane transporter activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;receptor binding;transporter activity angiogenesis;ATP biosynthetic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 27 27 27 71.5 71.5 71.5 56.559 0 18533000000 9450300000 9082300000 4111 IPI:IPI00303476.1 ATP synthase subunit beta, mitochondrial ATP5B;ATPMB;ATPSB P06576 ENST00000262030 K02133 1 0.74214 1.442 0.79361 0.95376 0.95652 1.0277 Glutaredoxin;GST_C Golgi membrane;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane;membrane part;membrane-bounded organelle;mitochondrion;organelle;organelle membrane;organelle part binding;catalytic activity;disulfide oxidoreductase activity;electron carrier activity;isomerase activity;oxidoreductase activity;oxidoreductase activity, acting on sulfur group of donors;protein binding;protein disulfide oxidoreductase activity fatty acid biosynthetic process;fatty acid metabolic process;icosanoid metabolic process;lipid metabolic process;organic acid metabolic process;prostaglandin biosynthetic process;prostanoid metabolic process;unsaturated fatty acid biosynthetic process Arachidonic acid metabolism 8 8 8 28.9 28.9 28.9 41.943 5.9291E-209 137420000 72601000 64822000 4112 IPI:IPI00303568.3 Prostaglandin E synthase 2;Microsomal prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form PTGES2;C9orf15;PGES2 Q9H7Z7 ENST00000338961 K05309 1 0.86506 1.5521 NaN 1.0782 1.0783 NaN DUF1855 binding;protein binding dorsal/ventral pattern formation;negative regulation of signal transduction;pattern specification process;regionalization;regulation of cell communication;regulation of protein kinase cascade;regulation of signal transduction 2 2 2 6.9 6.9 6.9 35.023 4.284E-05 2847800 1658300 1189500 4114 IPI:IPI00303602.1;IPI:IPI00480020.1 Axin interactor, dorsalization-associated protein;Axin interaction partner and dorsalization antagonist AIDA;C1orf80 Q96BJ3-1;Q96BJ3;Q96BJ3-3 ENST00000340020 2 0.73432 1.4358 NaN 0.91971 0.97785 NaN DUF1650 cell part;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part binding;calcium channel activity;calcium ion binding;cation channel activity;cation transmembrane transporter activity;channel activity;ion channel activity;ion transmembrane transporter activity;protein binding;transporter activity calcium ion transport;cation transport;di-, tri-valent inorganic cation transport;immune response;immune system process;ion transport;metal ion transport;regulation of ion transport;regulation of localization;regulation of metal ion transport;transport 2 2 2 10.9 10.9 10.9 32.862 3.1091E-17 33071000 16369000 16701000 4115 IPI:IPI00303699.6 Calcium release-activated calcium channel protein 1;Protein orai-1;Transmembrane protein 142A ORAI1;CRACM1;TMEM142A Q96D31 ENST00000330079 1 0.68344 1.4518 0.77124 0.91171 0.97114 0.94841 DUF842 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle binding;protein binding 4 4 4 30.4 30.4 30.4 15.641 1.1846E-73 498870000 273090000 225780000 4116 IPI:IPI00303722.5 Protein FAM136A FAM136A Q96C01 ENST00000037869 1 0.55236 1.1799 0.54789 0.78313 0.74085 0.75756 Sel1 binding 2 2 2 11.3 11.3 11.3 25.709 0.0001765 57385000 37586000 19798000 4117 IPI:IPI00303753.6 Hcp beta-lactamase-like protein C1orf163 C1orf163 Q96BR5 ENST00000371538 1 0.71928 1.6347 NaN 1.0131 1.0137 NaN 2 2 2 7.8 7.8 7.8 38.367 9.6222E-67 5016900 2799800 2217100 4118 IPI:IPI00303812.7 Uncharacterized protein C9orf82 C9orf82 Q9H8G2 ENST00000333916 1 0.49994 1.0175 0.51471 0.69759 0.66688 0.64939 NUC205 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part 8 8 8 13.6 13.6 13.6 81.123 4.2346E-134 119490000 61121000 58369000 4119 IPI:IPI00303813.5 Nucleolar protein 11 NOL11;L14 Q9H8H0 ENST00000253247 1 0.8808 1.6424 0.87735 1.1633 1.1109 1.1796 Plus-3 cell part;cytoplasm;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;DNA binding;nucleic acid binding;protein binding cellular process;chromatin organization;metabolic process;organelle organization;protein modification process;regulation of biosynthetic process;regulation of gene expression;regulation of transcription, DNA-dependent;transcription initiation 9 9 9 14.6 14.6 14.6 80.313 1.6713E-61 180010000 97906000 82107000 4120 IPI:IPI00303832.6 RNA polymerase-associated protein RTF1 homolog RTF1;KIAA0252 Q92541 ENST00000389628;ENST00000389629 1 0.64424 1.3454 0.64194 0.87104 0.89589 0.82507 Glycogen_syn cell part;cytoplasmic part;cytosol;intracellular part binding;catalytic activity;glycogen (starch) synthase activity;protein binding;transferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring hexosyl groups;UDP-glycosyltransferase activity carbohydrate metabolic process;cellular glucan metabolic process;generation of precursor metabolites and energy;glycogen biosynthetic process;glycogen metabolic process;polysaccharide biosynthetic process;polysaccharide metabolic process Insulin signaling pathway;Starch and sucrose metabolism 9 9 9 15.6 15.6 15.6 83.785 3.2202E-36 159840000 77778000 82060000 4121 IPI:IPI00303868.1;IPI:IPI00008867.1 Glycogen [starch] synthase, muscle GYS1;GYS P13807 ENST00000323798 K00693 2 1.0444 1.7467 1.1519 1.3646 1.155 1.5216 Perilipin endosome membrane;Golgi apparatus;intracellular organelle;membrane;membrane-bounded organelle;monolayer-surrounded lipid storage body outer lipid monolayer;organelle;organelle membrane;organelle-enclosing lipid monolayer cellular process;establishment of localization;transport;vesicle-mediated transport 11 11 11 37.1 37.1 37.1 47.046 1.5225E-236 368190000 185840000 182360000 4122 IPI:IPI00303882.2;IPI:IPI00106668.5 Mannose-6-phosphate receptor-binding protein 1;Cargo selection protein TIP47;47 kDa mannose 6-phosphate receptor-binding protein;Placental protein 17 M6PRBP1;TIP47 O60664-1;O60664;O60664-2 ENST00000221957 2 0.82586 1.5055 0.54518 1.0345 1.028 0.67977 Nol1_Nop2_Fmu catalytic activity;methyltransferase activity;transferase activity;transferase activity, transferring one-carbon groups 4 4 4 9.1 9.1 9.1 43.088 3.0344E-11 30775000 16132000 14643000 4124 IPI:IPI00303944.6;IPI:IPI00847563.1;IPI:IPI00847475.1 Putative methyltransferase NSUN4;NOL1/NOP2/Sun domain family member 4 NSUN4 Q96CB9-1;Q96CB9;Q96CB9-3 ENST00000307089 3 0.85943 1.6421 0.90432 1.0073 1.1355 1.0563 Cyt-b5 cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial membrane;mitochondrial outer membrane;mitochondrial part;organelle membrane;organelle outer membrane;organelle part;outer membrane binding;cation binding;heme binding;ion binding;iron ion binding;metal ion binding;tetrapyrrole binding;transition metal ion binding cellular metabolic process;cellular process;electron transport chain;establishment of localization;generation of precursor metabolites and energy;metabolic process;oxidation reduction;transport 5 5 5 52 52 52 16.694 2.1479E-52 605350000 315960000 289390000 4125 IPI:IPI00303954.3 Cytochrome b5 type B;Cytochrome b5 outer mitochondrial membrane isoform CYB5B;CYB5M;OMB5 O43169 ENST00000307892;ENST00000393753 1 0.8483 1.8846 0.72593 1.1784 1.2637 0.95087 AMP-binding cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;catalytic activity;ligase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding carboxylic acid metabolic process;cellular ketone metabolic process;cellular process;fatty acid metabolic process;lipid metabolic process;metabolic process;monocarboxylic acid metabolic process;organic acid metabolic process;oxoacid metabolic process 10 10 10 22 22 22 68.124 3.9552E-74 119190000 63628000 55562000 4126 IPI:IPI00304071.4 Acyl-CoA synthetase family member 2, mitochondrial ACSF2;UNQ493/PRO1009 Q96CM8 ENST00000300441 1 0.74567 1.3048 0.73259 0.98715 0.87427 1.0057 Isochorismatase cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;microbody;organelle;peroxisome catalytic activity metabolic process 12 12 12 51.3 51.3 51.3 32.236 7.1436E-238 295960000 157240000 138720000 4127 IPI:IPI00304082.8 Isochorismatase domain-containing protein 1 ISOC1;CGI-111 Q96CN7 ENST00000173527 1 0.66969 1.3367 0.68511 0.90968 0.8387 0.90159 RRM_1 intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;nucleotide binding;RNA binding cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 17 17 17 24.2 24.2 24.2 85.737 9.2703E-118 421330000 222240000 199090000 4128 IPI:IPI00304187.8 RNA-binding protein 28;RNA-binding motif protein 28 RBM28 Q9NW13 ENST00000223073 1 NaN 1.2851 NaN NaN 0.83783 NaN 2 2 2 7.8 7.8 7.8 35.085 2.9989E-09 6013600 3112700 2900900 4129 IPI:IPI00304198.7 Protein SLC7A6OS;Solute carrier family 7 member 6 opposite strand transcript;ADAMS proteinase-related protein SLC7A6OS Q96CW6 ENST00000263997 1 0.64474 1.4207 NaN 0.80704 0.9588 NaN cell part;integral to membrane;intrinsic to membrane;membrane part 2 2 2 8.1 8.1 8.1 40.264 6.0038E-49 1610600 934460 676120 4130 IPI:IPI00304214.5 Protein FAM118A FAM118A;C22orf8 Q9NWS6 ENST00000216214;ENST00000405548 1 0.62674 1.1498 0.66157 0.84482 0.75457 0.88488 NLE;WD40 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleolar part;nucleoplasm;organelle part;PeBoW complex;preribosome;preribosome, large subunit precursor;protein complex;ribonucleoprotein complex binding;protein binding maturation of 5.8S rRNA;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);maturation of LSU-rRNA;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 11 11 11 36.2 36.2 36.2 47.707 1.3419E-193 676800000 368610000 308180000 4131 IPI:IPI00304232.1 Ribosome biogenesis protein WDR12;WD repeat-containing protein 12 WDR12 Q9GZL7 ENST00000261015 1 1.0971 2.0342 1.0018 1.4514 1.4107 1.343 AhpC-TSA cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;oxidoreductase activity, acting on sulfur group of donors;oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor cell communication;cell differentiation;cell surface receptor linked signal transduction;cellular homeostasis;cellular process;metabolic process;multicellular organismal development;signal transduction;Wnt receptor signaling pathway 6 6 3 18.9 18.9 11.5 48.392 5.3864E-117 71091000 35765000 35326000 4133 IPI:IPI00304267.3 Nucleoredoxin NXN;NRX Q6DKJ4-1;Q6DKJ4 ENST00000336868;ENST00000397383 1 0.6372 1.7782 0.71994 0.84397 1.0338 0.97376 DnaJ cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part binding;heat shock protein binding;protein binding cellular process;intracellular protein transport;metabolic process;mitochondrial transport;protein folding;protein import;protein targeting;protein targeting to mitochondrion;protein transport;sensory perception;system process;transport;visual perception 5 5 5 39.7 39.7 39.7 12.498 3.7359E-40 72757000 38907000 33850000 4134 IPI:IPI00304306.5 Mitochondrial import inner membrane translocase subunit TIM14;DnaJ homolog subfamily C member 19 DNAJC19;TIM14;TIMM14 Q96DA6 ENST00000382564 K09539 1 NaN 1.6277 NaN NaN 1.0936 NaN Glyco_transf_43 cell part;cytoplasmic part;Golgi apparatus part;Golgi membrane;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part binding;catalytic activity;galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity;glucuronosyltransferase activity;transferase activity;transferase activity, transferring glycosyl groups;UDP-glycosyltransferase activity aminoglycan biosynthetic process;aminoglycan metabolic process;carbohydrate metabolic process;glycosaminoglycan biosynthetic process;metabolic process;nitrogen compound metabolic process;polysaccharide biosynthetic process;polysaccharide metabolic process Chondroitin sulfate biosynthesis;Heparan sulfate biosynthesis 3 3 3 10.4 10.4 10.4 37.121 1.2414E-07 3043100 1686100 1357000 4135 IPI:IPI00304331.2 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3;Beta-1,3-glucuronyltransferase 3;Glucuronosyltransferase-I;UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase B3GAT3 O94766 ENST00000265471 K10158 1 0.76847 1.4861 0.82592 1.0192 0.96099 1.0982 CSD cell part;cytoplasm;intracellular part binding;DNA binding;enzyme binding;nucleic acid binding;phosphatase binding;protein binding cell communication;cellular process;intracellular signaling cascade;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of transcription, DNA-dependent;signal transduction 3 3 3 34.7 34.7 34.7 15.892 2.1763E-103 110720000 58623000 52101000 4137 IPI:IPI00304409.3 Calcium-regulated heat stable protein 1;Calcium-regulated heat-stable protein of 24 kDa CARHSP1 Q9Y2V2 ENST00000311052;ENST00000396593 1 0.82553 1.5369 0.83785 1.0905 0.99056 1.0932 Iso_dh cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part binding;catalytic activity;electron carrier activity;isocitrate dehydrogenase (NAD+) activity;isocitrate dehydrogenase activity;magnesium ion binding;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors acetyl-CoA metabolic process;catabolic process;coenzyme catabolic process;coenzyme metabolic process;isocitrate metabolic process;metabolic process;organic acid metabolic process;sensory perception;system process;tricarboxylic acid cycle;visual perception Citrate cycle (TCA cycle) 15 15 15 49.4 49.4 49.4 42.881 9.447E-299 771880000 403690000 368190000 4138 IPI:IPI00304417.7;IPI:IPI00304419.2 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial;Isocitric dehydrogenase;NAD(+)-specific ICDH IDH3B O43837-1;O43837;O43837-2 ENST00000380843;ENST00000380851 K00030 2 0.87128 1.7343 0.86924 1.1297 1.1339 1.0928 NIPSNAP 13 13 12 50.7 50.7 50.7 33.31 4.2413E-72 1072200000 567730000 504440000 4139 IPI:IPI00304435.3 Protein NipSnap homolog 1 NIPSNAP1 Q9BPW8 ENST00000216121 1 0.61214 1.5818 NaN 0.83262 1.0024 NaN NTP_transf_2;PAP_central;PAP_RNA-bind cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;nucleic acid binding;nucleoside binding;nucleotide binding;polynucleotide adenylyltransferase activity;purine nucleoside binding;RNA binding;transferase activity biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA processing;transcription 2 2 2 2.7 2.7 2.7 82.802 4.721E-07 4136300 2138600 1997700 4140 IPI:IPI00304442.4 Poly(A) polymerase gamma;Polynucleotide adenylyltransferase gamma;SRP RNA 3'-adenylating enzyme;Neo-poly(A) polymerase PAPOLG;PAP2;PAPG Q9BWT3 ENST00000238714 K00970 1 NaN 1.1686 NaN NaN 0.82737 NaN DUF1308 2 2 2 5.7 5.7 5.7 46.45 3.0381E-05 434160 224470 209690 4141 IPI:IPI00304461.3 UPF0415 protein C7orf25 C7orf25 Q9BPX7 ENST00000350427 1 0.86771 1.2064 0.97475 1.0787 0.85553 1.2812 chromatin;chromosomal part;cytoplasm;heterochromatin;intracellular organelle part;intracellular part;nuclear chromatin;nuclear chromosome part;nuclear heterochromatin;nuclear part;nuclear telomeric heterochromatin;organelle part;telomeric heterochromatin ankyrin binding;binding;cytoskeletal protein binding;enzyme binding;protein binding DNA metabolic process;DNA replication;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;RNA-dependent DNA replication;telomere maintenance;telomere maintenance via telomerase 3 3 3 2.8 2.8 2.8 181.78 2.98E-11 34396000 16268000 18127000 4142 IPI:IPI00304589.4;IPI:IPI00847646.1 182 kDa tankyrase-1-binding protein TNKS1BP1;KIAA1741;TAB182 Q9C0C2-1;Q9C0C2 ENST00000326757;ENST00000358252 2 0.8144 1.5414 0.819 1.0742 1.0378 1.0601 NOPS;RRM_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;identical protein binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding DNA metabolic process;DNA recombination;DNA repair;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;RNA processing;transcription 28 28 26 61.6 61.6 58.6 54.231 0 7051600000 3565300000 3486300000 4143 IPI:IPI00304596.3 Non-POU domain-containing octamer-binding protein;54 kDa nuclear RNA- and DNA-binding protein;p54(nrb);55 kDa nuclear protein;NMT55;DNA-binding p52/p100 complex, 52 kDa subunit NONO;NRB54 Q15233 ENST00000276079;ENST00000373841;ENST00000373856 1 0.71635 1.2588 0.97858 0.93466 0.84148 1.2196 Ribosomal_L13 cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;large ribosomal subunit;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 12 12 12 43.3 43.3 43.3 23.577 2.9587E-130 6197700000 3073800000 3123900000 4144 IPI:IPI00304612.9;IPI:IPI00432865.1;IPI:IPI00376475.2 60S ribosomal protein L13a;23 kDa highly basic protein RPL13A P40429 ENST00000270634 K02872 3 NaN 1.4826 NaN NaN 0.90496 NaN 2 2 2 5.9 5.9 5.9 44.139 1.4767E-22 674330 365060 309270 4145 IPI:IPI00304655.2 Uncharacterized protein KIAA1712;HBV PreS1-transactivated protein 3 KIAA1712 Q9C0F1 ENST00000296519;ENST00000396791 1 NaN 1.0047 0.44265 NaN 0.69298 0.57063 PH;Sec7 cell part;intracellular;membrane;plasma membrane ARF guanyl-nucleotide exchange factor activity;enzyme regulator activity;GTPase regulator activity;guanyl-nucleotide exchange factor activity;nucleoside-triphosphatase regulator activity;small GTPase regulator activity regulation of ARF protein signal transduction;regulation of biological process;regulation of cell communication;regulation of cellular process;regulation of Ras protein signal transduction;regulation of signal transduction 4 4 4 3.2 3.2 3.2 116.25 1.9235E-50 25346000 12836000 12510000 4146 IPI:IPI00304670.7;IPI:IPI00787751.1 PH and SEC7 domain-containing protein 4;Pleckstrin homology and SEC7 domain-containing protein 4;Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B;Telomeric of interleukin-1 cluster protein PSD4;EFA6B;TIC Q8NDX1-1;Q8NDX1;Q8NDX1-2 ENST00000245796 2 0.58514 0.93353 NaN 0.72494 0.66662 NaN cell part;integral to membrane;integrator complex;intracellular organelle part;intracellular part;intrinsic to membrane;macromolecular complex;membrane part;nuclear part;nucleoplasm part;organelle part;protein complex binding;protein binding cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;snRNA metabolic process;snRNA processing 6 6 6 7 7 7 107.99 2.238E-13 10410000 5947000 4463300 4147 IPI:IPI00304676.5 Integrator complex subunit 5 INTS5;KIAA1698 Q6P9B9 ENST00000330574 1 0.70516 1.4636 0.72753 0.97032 0.96568 0.99284 RBM1CTR;RRM_1 cell part;heterogeneous nuclear ribonucleoprotein complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 27 27 27 59.6 59.6 59.6 42.331 0 5082600000 2711600000 2371000000 4148 IPI:IPI00304692.1;IPI:IPI00004450.2;IPI:IPI00167369.2 Heterogeneous nuclear ribonucleoprotein G;RNA-binding motif protein, X chromosome;Glycoprotein p43;Heterogeneous nuclear ribonucleoprotein G, N-terminally processed RBMX;HNRPG;RBMXP1 P38159 ENST00000320676 3 0.89043 1.6277 0.88325 1.1637 1.0772 1.2151 ArfGap cell part;cytoplasmic part;cytoplasmic vesicle;intracellular organelle;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;organelle;organelle part;pore complex;protein complex;vesicle ARF GTPase activator activity;binding;DNA binding;enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;nucleic acid binding;protein binding;RNA binding;small GTPase regulator activity;zinc ion binding cellular process;gamete generation;mRNA export from nucleus;multicellular organismal development;nucleobase, nucleoside, nucleotide and nucleic acid transport;nucleocytoplasmic transport;RNA export from nucleus;spermatogenesis;transport 5 5 5 13.9 13.9 13.9 58.259 9.961E-34 80812000 41603000 39209000 4149 IPI:IPI00607616.2;IPI:IPI00736669.1;IPI:IPI00304693.6 Arf-GAP domain and FG repeats-containing protein 1;Nucleoporin-like protein RIP;HIV-1 Rev-binding protein;Rev-interacting protein;Rev/Rex activation domain-binding protein AGFG1;HRB;RAB;RIP P52594-1;P52594;P52594-3;P52594-2 ENST00000310078;ENST00000373671;ENST00000409979 3 0.79856 1.3596 NaN 1.0618 0.84451 NaN Pkinase ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cellular biopolymer metabolic process;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process 3 3 3 4.6 4.6 4.6 112.13 3.0112E-40 2829600 1548100 1281500 4150 IPI:IPI00304742.5 Serine/threonine-protein kinase 10;Lymphocyte-oriented kinase STK10;LOK O94804 ENST00000176763 K08837 1 0.80913 1.6377 0.82873 1.1237 1.0226 1.0455 GSHPx antioxidant activity;binding;catalytic activity;glutathione peroxidase activity;oxidoreductase activity;oxidoreductase activity, acting on peroxide as acceptor;peroxidase activity;phospholipid-hydroperoxide glutathione peroxidase activity;selenium binding cellular metabolic process;cellular process;developmental process;lipid metabolic process;metabolic process;multicellular organismal development;multicellular organismal process;organophosphate metabolic process;phospholipid metabolic process Arachidonic acid metabolism;Glutathione metabolism 9 9 9 47.2 47.2 47.2 22.128 2.8038E-61 310130000 173080000 137050000 4151 IPI:IPI00304814.4;IPI:IPI00745335.7 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial;GPX-4 GPX4 P36969-1;P36969;P36969-2 ENST00000354171 K00432 2 0.63556 1.2347 0.69756 0.87845 0.81459 0.94797 CHZ cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding cellular component organization;cellular process;chromatin assembly or disassembly;chromatin organization;chromosome organization;organelle organization 8 8 8 19.6 19.6 19.6 61.956 2.5026E-49 61450000 33104000 28346000 4152 IPI:IPI00304875.2;IPI:IPI00413871.3 HIRA-interacting protein 3 HIRIP3 Q9BW71-1;Q9BW71;Q9BW71-2 ENST00000279392;ENST00000352552 2 0.78025 1.8596 1.038 1.0435 1.1596 1.3977 Cupin_2 condensed chromosome kinetochore;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;kinetochore;macromolecular complex;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding 3 3 3 3.1 3.1 3.1 106.92 2.2183E-08 31844000 15426000 16418000 4153 IPI:IPI00304885.1 Centromere protein C 1;Centromere autoantigen C;Interphase centromere complex protein 7 CENPC1;CENPC;ICEN7 Q03188 ENST00000273853 K11497 1 2.7124 7.6629 2.597 3.5154 4.9758 3.3495 HSP70 cell part;cytoplasmic part;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;nucleus;organelle adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding anti-apoptosis;catabolic process;metabolic process;mRNA catabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to stress;response to unfolded protein;RNA catabolic process Antigen processing and presentation;MAPK signaling pathway 17 12 6 30.3 24 11.4 70.051 0 214570000 93034000 121540000 4154 IPI:IPI00304925.5 Heat shock 70 kDa protein 1;HSP70.1;HSP70-1/HSP70-2 HSPA1A;HSPA1;HSPA1B P08107 ENST00000375650;ENST00000375651;ENST00000391548;ENST00000391555;ENST00000399958 K03283 1 0.72317 1.3761 0.99215 0.88861 0.93783 1.2512 Methyltransf_8 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;protein binding 5 5 5 17.1 17.1 17.1 50.714 3.833E-69 88532000 45870000 42661000 4155 IPI:IPI00304932.2 Cerebral protein 1 KIAA0409;hucep-1 O43159 ENST00000254605 1 0.61026 1.326 0.73899 0.87699 0.83406 0.93055 extracellular region binding acute inflammatory response;acute-phase response;defense response;inflammatory response;response to external stimulus;response to stimulus;response to stress;response to wounding 7 7 7 20.2 20.2 20.2 53.655 3.1674E-135 63071000 33280000 29790000 4156 IPI:IPI00304935.6 Protein SAAL1 SAAL1 Q96ER3 ENST00000300013 1 0.67886 1.1432 NaN 0.84061 0.79882 NaN Rpr2 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;catalytic activity;endonuclease activity;endoribonuclease activity;hydrolase activity;hydrolase activity, acting on ester bonds;nuclease activity;protein binding;ribonuclease activity;ribonuclease P activity;tRNA-specific ribonuclease activity cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;tRNA metabolic process;tRNA processing 2 2 2 24.7 24.7 24.7 17.57 1.1508E-15 2544900 1266300 1278600 4157 IPI:IPI00304938.5;IPI:IPI00384602.3;IPI:IPI00384603.3 Ribonuclease P protein subunit p21;Ribonuclease P/MRP 21 kDa subunit;Ribonucleoprotein V RPP21;C6orf135;CAT60 Q9H633-1;Q9H633;Q9H633-3;Q9H633-2 ENST00000376640;ENST00000376644;ENST00000383453;ENST00000383456 K03540 3 0.9153 1.5856 0.88961 1.17 1.1005 1.1299 Metallophos binding;catalytic activity;cation binding;hydrolase activity;ion binding;metal ion binding 4 4 4 18.5 18.5 18.5 35.576 2.3105E-105 172740000 91173000 81567000 4158 IPI:IPI00305010.3;IPI:IPI00426077.3 Calcineurin-like phosphoesterase domain-containing protein 1;Complete S-transactivated protein 1 CPPED1;CSTP1 Q9BRF8-1;Q9BRF8;Q9BRF8-2 ENST00000261660;ENST00000381774 2 0.71627 1.2439 0.73991 0.92728 0.84901 0.94135 PRP1_N;TPR_1 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;catalytic activity;protein binding;receptor binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding;transcription regulator activity positive regulation of biosynthetic process;positive regulation of metabolic process;regulation of biosynthetic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;spliceosome assembly 24 24 24 30 30 30 106.92 2.2367E-170 751350000 408880000 342480000 4159 IPI:IPI00305068.5 Pre-mRNA-processing factor 6;U5 snRNP-associated 102 kDa protein;PRP6 homolog PRPF6;C20orf14 O94906 ENST00000266079 1 0.78994 2.0725 0.8928 1.0704 1.3561 1.2259 Mago-bind cell part;exon-exon junction complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex binding;protein binding;ribonucleoprotein binding;ribosome binding mRNA catabolic process;nuclear-transcribed mRNA catabolic process;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of translation;RNA catabolic process 6 6 6 38.2 38.2 38.2 22.655 6.9181E-170 99095000 51888000 47208000 4160 IPI:IPI00305092.7;IPI:IPI00790634.2 Partner of Y14 and mago;Protein wibg homolog WIBG;PYM Q9BRP8-1;Q9BRP8;Q9BRP8-2 ENST00000398213;ENST00000408946 2 0.80781 1.5284 0.77497 1.0247 1.0259 1.0263 3 3 3 13.4 13.4 13.4 34.285 0.00082509 74333000 38100000 36234000 4161 IPI:IPI00305144.1;IPI:IPI00657787.1 Protein TSSC4;Tumor-suppressing subchromosomal transferable fragment candidate gene 4 protein;Tumor-suppressing STF cDNA 4 protein TSSC4 Q9Y5U2-1;Q9Y5U2;Q9Y5U2-2 ENST00000333256;ENST00000380996 2 0.88499 1.5523 0.8848 1.0945 1.0716 1.0919 WD40 COPII vesicle coat;endoplasmic reticulum membrane;endoplasmic reticulum part;Golgi apparatus part;intracellular part;macromolecular complex;membrane;membrane coat;membrane part;organelle membrane;organelle part;protein complex;vesicle coat binding;calcium-dependent protein binding;protein binding cellular component organization;cellular process;ER to Golgi vesicle-mediated transport;membrane organization;protein transport;response to chemical stimulus;response to inorganic substance;response to metal ion;transport;vesicle-mediated transport 19 19 19 21.3 21.3 21.3 134.5 1.1463E-285 519680000 271140000 248540000 4162 IPI:IPI00852741.1;IPI:IPI00746182.2;IPI:IPI00795507.1;IPI:IPI00515103.2;IPI:IPI00305152.6;IPI:IPI00853220.1;IPI:IPI00445429.2;IPI:IPI00853290.1 Protein transport protein Sec31A;SEC31-related protein A;SEC31-like 1;ABP125;ABP130;Web1-like protein SEC31A;KIAA0905;SEC31L1;HSPC275;HSPC334 O94979-8;O94979;O94979-1;O94979-2;O94979-4;O94979-3;O94979-6;O94979-7;O94979-5 ENST00000264405;ENST00000311785;ENST00000348405;ENST00000355196;ENST00000395310 8 0.84836 1.5232 0.86749 1.0717 1.0222 1.1391 FAD_binding_2;Succ_DH_flav_C cell part;cytoplasmic part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;mitochondrial membrane part;mitochondrial part;mitochondrial respiratory chain complex II;organelle part;protein complex binding;catalytic activity;electron carrier activity;nucleoside binding;nucleotide binding;oxidoreductase activity;protein binding;purine nucleoside binding;succinate dehydrogenase (ubiquinone) activity acetyl-CoA metabolic process;coenzyme metabolic process;generation of precursor metabolites and energy;metabolic process;nervous system development;organic acid metabolic process;succinate metabolic process;transport;tricarboxylic acid cycle Alzheimer's disease;Citrate cycle (TCA cycle);Huntington's disease;Oxidative phosphorylation;Parkinson's disease 14 14 14 31.3 31.3 31.3 72.687 0 1172800000 614380000 558380000 4163 IPI:IPI00305166.2 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial;Flavoprotein subunit of complex II SDHA;SDH2;SDHF P31040 ENST00000264932 K00234 1 0.9829 1.9127 1.0016 1.2793 1.3187 1.3408 HCaRG 8 8 8 59.1 59.1 59.1 21.819 9.1241E-250 112430000 58088000 54339000 4164 IPI:IPI00305212.5 COMM domain-containing protein 9 COMMD9;HSPC166 Q9P000 ENST00000263401 1 0.85793 2.1147 0.91725 1.1603 1.3224 1.1813 cell part;cytoplasmic part;Golgi apparatus part;Golgi cisterna membrane;Golgi membrane;Golgi transport complex;intracellular organelle part;intracellular part;macromolecular complex;membrane;organelle membrane;organelle part;protein complex binding;protein binding;transporter activity cellular process;establishment of localization;establishment of localization in cell;Golgi vesicle transport;intracellular transport;intra-Golgi vesicle-mediated transport;transport;vesicle-mediated transport 12 12 12 10.2 10.2 10.2 167.35 9.7406E-119 27536000 15080000 12456000 4165 IPI:IPI00305267.2;IPI:IPI00333419.2;IPI:IPI00944623.1 Golgin subfamily A member 3;Golgin-160;Golgi complex-associated protein of 170 kDa GOLGA3 Q08378-1;Q08378;Q08378-2;Q08378-4 ENST00000204726 3 0.76722 1.99 NaN 1.0044 1.2691 NaN adh_short cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle catalytic activity;G-protein coupled receptor activity;icosanoid receptor activity;nucleotide binding;prostaglandin receptor activity;prostanoid receptor activity;receptor activity;signal transducer activity;transmembrane receptor activity cell communication;fatty acid metabolic process;icosanoid metabolic process;lipid metabolic process;organic acid metabolic process;prostaglandin metabolic process;prostanoid metabolic process;very-long-chain fatty acid metabolic process 2 2 2 8.3 8.3 8.3 28.977 3.4064E-10 25209000 14070000 11139000 4166 IPI:IPI00305286.1 15-hydroxyprostaglandin dehydrogenase [NAD+];Prostaglandin dehydrogenase 1 HPGD;PGDH1 P15428 ENST00000296522 K00069 1 1.2247 1.921 1.1581 1.5159 1.343 1.4763 Kinesin chromatin remodeling complex;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;kinesin complex;macromolecular complex;microtubule;microtubule associated complex;non-membrane-bounded organelle;organelle;protein complex;spindle ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;microtubule motor activity;motor activity;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity cellular process;cytoskeleton organization;microtubule cytoskeleton organization;microtubule-based movement;microtubule-based process;mitosis;mitotic spindle organization;nuclear division;organelle organization;spindle organization 24 24 24 28.1 28.1 28.1 119.16 2.5214E-280 658640000 317860000 340770000 4167 IPI:IPI00305289.2 Kinesin-like protein KIF11;Kinesin-related motor protein Eg5;Kinesin-like spindle protein HKSP;Thyroid receptor-interacting protein 5;Kinesin-like protein 1 KIF11;EG5;KNSL1;TRIP5 P52732 ENST00000260731 K10398 1 0.85382 1.8379 NaN 1.0598 1.2841 NaN DUF1649 2 2 2 13.3 13.3 13.3 25.002 1.1572E-14 14375000 10811000 3564100 4168 IPI:IPI00305296.2 UPF0453 protein C12orf44 C12orf44;PP894 Q9BSB4 ENST00000336854 1 NaN 1.0892 NaN NaN 0.65653 NaN Peptidase_C78 catalytic activity;cysteine-type peptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 4 4 4 11.7 11.7 11.7 53.261 2.2357E-14 5138900 3086300 2052600 4169 IPI:IPI00305303.3 Ufm1-specific protease 2 UFSP2;C4orf20 Q9NUQ7 ENST00000264689 1 0.83003 1.4332 0.73621 1.0141 0.95391 1.0756 TRAM_LAG1_CLN8 cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;nuclear membrane;nuclear part;organelle membrane;organelle part binding;DNA binding;nucleic acid binding;protein binding;sequence-specific DNA binding;transcription factor activity;transcription regulator activity biosynthetic process;lipid biosynthetic process;lipid metabolic process;metabolic process;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of transcription, DNA-dependent 4 4 4 9.2 9.2 9.2 44.876 2.4705E-27 125490000 64518000 60975000 4170 IPI:IPI00305304.3 LAG1 longevity assurance homolog 2;Tumor metastasis-suppressor gene 1 protein;SP260 LASS2;TMSG1 Q96G23 ENST00000271688;ENST00000368949;ENST00000368954 1 0.43805 NaN 0.37267 0.52386 NaN 0.48567 PDZ;Rap_GAP cell part;cytoplasmic part;endomembrane system;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;nucleus;organelle;perinuclear region of cytoplasm binding;enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;protein binding;Rap GTPase activator activity;Ras GTPase activator activity;small GTPase regulator activity cell communication;cell proliferation;cellular process;cytoskeleton organization;intracellular signaling cascade;negative regulation of cell adhesion;organelle organization;regulation of cell growth;regulation of signal transduction;signal transduction Leukocyte transendothelial migration 3 3 3 6.1 6.1 6.1 112.15 5.1572E-08 3438200 2050700 1387500 4171 IPI:IPI00305305.3 Signal-induced proliferation-associated protein 1;GTPase-activating protein Spa-1;p130 SPA-1 SIPA1;SPA1 Q96FS4 ENST00000308755;ENST00000394224;ENST00000394227 K08013 1 0.65728 1.4871 0.64438 0.89016 0.98089 0.82258 Death cell part;intracellular organelle part;intracellular part;nuclear body;nuclear matrix;nuclear part;nuclear speck;nucleoplasm part;organelle part binding;DNA binding;nucleic acid binding;protein binding;RNA binding cell communication;cellular process;metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA processing;RNA splicing;signal transduction;transport 12 12 12 19.2 19.2 19.2 75.665 4.4282E-49 200700000 111590000 89110000 4173 IPI:IPI00305374.5;IPI:IPI00646620.2;IPI:IPI00944519.1 THO complex subunit 1;Nuclear matrix protein p84 THOC1;HPR1 Q96FV9-1;Q96FV9;Q96FV9-2 ENST00000261600 3 0.66124 1.2788 0.64135 0.86139 0.87205 0.81617 Peptidase_M16;Peptidase_M16_C intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;mitochondrial inner membrane;mitochondrial membrane;nucleus;organelle;organelle inner membrane;organelle membrane;organelle part binding;catalytic activity;cation binding;endopeptidase activity;hydrolase activity;ion binding;metal ion binding;metalloendopeptidase activity;metallopeptidase activity;peptidase activity;protein binding;transition metal ion binding;zinc ion binding aerobic respiration;catabolic process;generation of precursor metabolites and energy;macromolecule catabolic process;metabolic process;oxidative phosphorylation;phosphate metabolic process;phosphorus metabolic process;proteolysis;transport Alzheimer's disease;Cardiac muscle contraction;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 18 18 18 42.6 42.6 42.6 48.442 0 1462100000 806610000 655490000 4174 IPI:IPI00305383.1 Cytochrome b-c1 complex subunit 2, mitochondrial;Ubiquinol-cytochrome-c reductase complex core protein 2;Core protein II;Complex III subunit 2 UQCRC2 P22695 ENST00000268379 K00415 1 0.48021 0.90433 0.47216 0.63611 0.61999 0.62141 Vps16_C;Vps16_N cell part;cytoplasmic part;endosomal part;endosome membrane;intracellular organelle part;intracellular part;late endosome membrane;lysosomal membrane;membrane;organelle membrane;organelle part;vacuolar membrane;vacuolar part establishment of localization;establishment of localization in cell;establishment of protein localization;intracellular protein transport;intracellular transport;protein transport;transport 11 11 11 17.9 17.9 17.9 94.693 8.5302E-80 128860000 73557000 55302000 4176 IPI:IPI00305438.3;IPI:IPI00305439.3 Vacuolar protein sorting-associated protein 16 homolog VPS16 Q9H269-1;Q9H269;Q9H269-2 ENST00000380445;ENST00000380469 2 0.54659 1.3368 NaN 0.75382 0.82075 NaN Metallophos cell part;cytoplasmic part;cytosol;intracellular part binding;calmodulin binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;iron ion binding;phosphatase activity;phosphoprotein phosphatase activity;phosphoric ester hydrolase activity;protein binding;zinc ion binding activation of pro-apoptotic gene products;positive regulation of apoptosis;positive regulation of cell death;positive regulation of programmed cell death;regulation of apoptosis;regulation of cell death;regulation of programmed cell death 5 3 3 10.7 7 7 58.129 3.847E-31 3787600 2138600 1649000 4177 IPI:IPI00413731.3;IPI:IPI00305491.5 Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform;Calmodulin-dependent calcineurin A subunit gamma isoform;Calcineurin, testis-specific catalytic subunit;CAM-PRP catalytic subunit PPP3CC;CALNA3;CNA3 P48454-1;P48454;P48454-2 ENST00000289963;ENST00000397775 2 0.76693 1.2246 0.65519 1.0086 0.83067 0.85385 DBR1;Metallophos cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;endonuclease activity;endoribonuclease activity;hydrolase activity;hydrolase activity, acting on ester bonds;nuclease activity;ribonuclease activity;RNA lariat debranching enzyme activity 9 9 9 18.2 18.2 18.2 61.554 3.5127E-116 70187000 40042000 30145000 4178 IPI:IPI00305545.2;IPI:IPI00787976.1 Lariat debranching enzyme DBR1 Q9UK59-1;Q9UK59 ENST00000260803 2 0.71065 1.5904 0.93206 0.96958 1.1085 1.1462 6PF2K;PGAM 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex;cell part;cytoplasmic part;cytosol;cytosolic part;intracellular part;macromolecular complex;protein complex 6-phosphofructo-2-kinase activity;ATP binding;binding;catalytic activity;fructose-2,6-bisphosphate 2-phosphatase activity;kinase activity;nucleoside binding;nucleotide binding;phosphofructokinase activity;purine nucleoside binding;transferase activity alcohol metabolic process;carbohydrate metabolic process;fructose 2,6-bisphosphate metabolic process;fructose metabolic process;glucose metabolic process;hexose metabolic process;metabolic process;monosaccharide metabolic process;primary metabolic process Fructose and mannose metabolism 8 8 6 16 16 12.3 58.476 1.2921E-34 44048000 23535000 20513000 4179 IPI:IPI00305589.3;IPI:IPI00220808.1;IPI:IPI00783603.2;IPI:IPI00004511.3;IPI:IPI00216306.1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2;PFK-2/FBPase-2;6PF-2-K/Fru-2,6-P2ASE heart-type isozyme;6-phosphofructo-2-kinase;Fructose-2,6-bisphosphatase;6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1;6PF-2-K/Fru-2,6-P2ASE liver isozyme PFKFB2;PFKFB1;F6PK;PFRX O60825-1;O60825;O60825-2;P16118 ENST00000367079;ENST00000367080;ENST00000375006 K00900;K01103 5 NaN 1.7614 NaN NaN 1.1775 NaN Transglut_C;Transglut_core;Transglut_N cell part;cornified envelope;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane part;non-membrane-bounded organelle;organelle acyltransferase activity;binding;calcium ion binding;catalytic activity;protein binding;protein-glutamine gamma-glutamyltransferase activity;transferase activity;transferase activity, transferring acyl groups cell differentiation;cellular component organization;cellular process;epidermal cell differentiation;keratinization;keratinocyte differentiation;metabolic process;peptide cross-linking;protein metabolic process;protein modification process 2 2 2 3.1 3.1 3.1 89.786 3.4508E-31 541000 541000 0 4181 IPI:IPI00305622.4 Protein-glutamine gamma-glutamyltransferase K;Transglutaminase K;Transglutaminase-1;Epidermal TGase TGM1;KTG P22735 ENST00000206765 K05619 1 0.65127 1.2668 NaN 0.82483 0.88674 NaN DUF647 cell part;integral to membrane;intrinsic to membrane;membrane part 2 2 2 3.6 3.6 3.6 51.017 2.0787E-08 7507600 4148300 3359300 4182 IPI:IPI00305627.7 UPF0420 protein C16orf58 C16orf58 Q96GQ5-1;Q96GQ5 ENST00000327237 1 0.70668 1.475 0.6339 0.92511 0.97507 0.85344 intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;mitochondrion;organelle;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 2 2 2 12.8 12.8 12.8 14.226 7.9828E-06 20452000 11546000 8906000 4183 IPI:IPI00305668.7 28S ribosomal protein S6, mitochondrial;S6mt;MRP-S6 MRPS6;C21orf101;RPMS6 P82932 ENST00000362077;ENST00000399312 1 0.92786 1.6591 0.90844 1.2298 1.0919 1.2188 DUF1000;Thioredoxin cell part;cytoplasm;intracellular part catalytic activity;disulfide oxidoreductase activity;oxidoreductase activity;oxidoreductase activity, acting on sulfur group of donors cell redox homeostasis;cellular homeostasis;cellular metabolic process;cellular process;electron transport chain;generation of precursor metabolites and energy;homeostatic process;metabolic process;regulation of biological process;transport 13 13 13 62.6 62.6 62.6 32.251 1.2699E-301 662750000 349370000 313380000 4184 IPI:IPI00305692.5 Thioredoxin-like protein 1;32 kDa thioredoxin-related protein TXNL1;TRP32;TXL;TXNL O43396 ENST00000217515 1 0.6755 1.381 0.61494 0.93676 0.86811 0.88753 fn3;SPRY centrosome;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;microtubule;microtubule organizing center;non-membrane-bounded organelle;nucleus;organelle;organelle part cell cycle phase;cell cycle process;cell division;cellular component organization;cellular process;mitosis;nuclear division;organelle fission;organelle organization 4 4 4 8.9 8.9 8.9 55.819 4.4103E-40 15411000 8527800 6883600 4185 IPI:IPI00305827.4 Fibronectin type III and SPRY domain-containing protein 1;Microtubule-associated protein GLFND;MID1-related protein 1 FSD1;GLFND;MIR1;VLP27 Q9BTV5 ENST00000221856 1 0.59613 1.0478 0.60996 0.79215 0.70115 0.75855 WD40 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 16 16 16 37.8 37.8 37.8 57.543 1.2207E-162 987360000 548310000 439050000 4186 IPI:IPI00305833.3 WD40 repeat-containing protein SMU1;Smu-1 suppressor of mec-8 and unc-52 protein homolog SMU1 Q2TAY7 ENST00000379752;ENST00000397149 1 0.94383 1.4635 0.8736 1.2693 0.92492 1.178 Nuf2 condensed chromosome kinetochore;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;kinetochore;macromolecular complex;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle binding;protein binding cell cycle phase;cell cycle process;cell division;cellular component organization;cellular process;chromosome segregation;mitosis;nuclear division;organelle fission;organelle organization 3 3 3 7.1 7.1 7.1 54.303 1.078E-06 19669000 9750100 9919200 4187 IPI:IPI00305887.1 Kinetochore protein Nuf2;Cell division cycle-associated protein 1 NUF2;CDCA1;NUF2R Q9BZD4 ENST00000271452;ENST00000367900 K11548 1 0.89707 1.4682 0.89514 1.1102 1.0794 1.1205 Aldo_ket_red cell part;cytoplasmic part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle aldehyde reductase activity;aldo-keto reductase activity;catalytic activity;electron carrier activity;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors carbohydrate metabolic process;cellular aldehyde metabolic process;cellular metabolic process;cellular process;metabolic process;oxidation reduction;primary metabolic process 7 7 7 25.3 25.3 25.3 39.589 3.3635E-251 381490000 195180000 186300000 4189 IPI:IPI00305978.4;IPI:IPI00169280.5;IPI:IPI00293721.3 Aflatoxin B1 aldehyde reductase member 2;AFB1-AR 1;Aldoketoreductase 7 AKR7A2;AFAR;AFAR1;AKR7 O43488 ENST00000235835 3 0.63676 1.7048 NaN 0.94783 1.045 NaN Med18 cell part;intracellular organelle part;intracellular part;macromolecular complex;mediator complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;general RNA polymerase II transcription factor activity;identical protein binding;protein binding;RNA polymerase II transcription factor activity;RNA polymerase II transcription mediator activity;transcription regulator activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 3 3 3 15.8 15.8 15.8 24.452 1.3987E-07 39823000 16821000 23002000 4190 IPI:IPI00305986.4 Mediator of RNA polymerase II transcription subunit 18;Mediator complex subunit 18;p28b MED18 Q9BUE0 ENST00000373842;ENST00000398997 1 0.722 1.4612 0.7831 0.9903 0.92747 1.0416 YTH humoral immune response;immune response;immune system process;response to stimulus 8 8 5 15.5 15.5 10.9 62.333 5.1296E-93 424560000 224990000 199580000 4192 IPI:IPI00306043.1;IPI:IPI00397024.1;IPI:IPI00414899.7 YTH domain family protein 2;High-glucose-regulated protein 8;CLL-associated antigen KW-14;Renal carcinoma antigen NY-REN-2 YTHDF2;HGRG8 Q9Y5A9-1;Q9Y5A9;Q9Y5A9-2 ENST00000331716;ENST00000373812 3 0.62767 1.4288 0.58639 0.8565 0.83475 0.77761 AAA ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity 15 4 3 19.1 7.1 5.2 72.572 8.4799E-78 35292000 21160000 14132000 4193 IPI:IPI00306048.5;IPI:IPI00178879.6 ATPase family AAA domain-containing protein 3B ATAD3B;KIAA1273 Q5T9A4-1;Q5T9A4;Q5T9A4-3 ENST00000308647 2 0.77152 1.3318 0.76182 0.9664 0.90154 0.94796 Misat_Myo_SegII;Tubulin cytoplasmic part;intracellular part;macromolecular complex;membrane;mitochondrial membrane;mitochondrial outer membrane;mitochondrial part;organelle membrane;organelle outer membrane;organelle part;outer membrane;protein complex anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;mitochondrion organization;organelle organization;protein complex assembly 5 5 4 10.7 10.7 9.5 61.835 1.2826E-16 40671000 23616000 17055000 4194 IPI:IPI00306049.6;IPI:IPI00855996.1;IPI:IPI00856007.1;IPI:IPI00642805.3;IPI:IPI00856061.2;IPI:IPI00787388.2 Protein misato homolog 1 MSTO1;LST005;SLTP005 Q9BUK6-1;Q9BUK6;Q9BUK6-2;Q9BUK6-3;Q9BUK6-7;Q9BUK6-5 ENST00000245564;ENST00000368341 6 NaN 2.2665 1.4225 NaN 1.5912 1.7411 RRM_1 cell part;cytoplasm;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;mRNA 3'-UTR binding;mRNA binding;nucleic acid binding;nucleotide binding;RNA binding mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to DNA damage stimulus;response to stress;RNA processing 2 2 2 10.9 10.9 10.9 25.498 3.3802E-09 10826000 4282400 6544100 4195 IPI:IPI00306057.2;IPI:IPI00827745.1;IPI:IPI00374855.1 RNA-binding protein 38;RNA-binding motif protein 38;RNA-binding region-containing protein 1;HSRNASEB;ssDNA-binding protein SEB4;CLL-associated antigen KW-5;RNA-binding protein 24;RNA-binding motif protein 24;RNA-binding region-containing protein 6 RBM38;RNPC1;SEB4;RBM24;RNPC6 Q9H0Z9-1;Q9H0Z9;Q9BX46-1;Q9BX46;Q9H0Z9-2 ENST00000342690;ENST00000379052 3 0.71946 1.2437 0.66872 0.93358 0.8521 0.85308 WD40 Cajal body;cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear body;nuclear part;nucleoplasm part;organelle part;ribonucleoprotein complex;telomerase holoenzyme complex binding;nucleic acid binding;protein binding;RNA binding anatomical structure formation;cellular component organization;cellular process;DNA metabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization 4 4 4 12 12 12 59.309 1.8371E-70 31509000 16365000 15144000 4196 IPI:IPI00306087.5 Telomerase Cajal body protein 1;WD repeat-containing protein 79;WD40 repeats-containing protein encoding RNA antisense to p53 WDR79;TCAB1;WRAP53 Q9BUR4 ENST00000316024;ENST00000396463 1 0.79977 1.4282 0.83579 1.0638 0.95552 1.0316 THUMP;UPF0020 binding;catalytic activity;methyltransferase activity;nucleic acid binding;protein binding;RNA binding;transferase activity;transferase activity, transferring one-carbon groups 9 9 9 17.8 17.8 17.8 57.002 1.4968E-30 193470000 100850000 92621000 4197 IPI:IPI00306127.1 THUMP domain-containing protein 3 THUMPD3 Q9BV44 ENST00000345094;ENST00000404270 1 1.0171 1.9207 NaN 1.2903 1.3153 NaN ADH_N;ADH_zinc_N cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle binding;catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on the CH-CH group of donors;oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor;zinc ion binding biosynthetic process;cellular process;fatty acid biosynthetic process;fatty acid metabolic process;lipid biosynthetic process;lipid metabolic process;metabolic process;organic acid biosynthetic process;organic acid metabolic process 2 2 2 7.2 7.2 7.2 40.427 4.9272E-12 3320600 1845400 1475200 4199 IPI:IPI00306159.7 Trans-2-enoyl-CoA reductase, mitochondrial;NRBF-1 MECR;NBRF1;CGI-63 Q9BV79 ENST00000263702 1 0.37911 1.5239 NaN 0.506 0.95339 NaN DUF2454 4 4 4 8.3 8.3 8.3 56.914 4.4155E-40 12190000 7167500 5022000 4201 IPI:IPI00306207.4 Uncharacterized protein C8orf41 C8orf41 Q6NXR4 ENST00000360742 1 0.5049 0.97037 0.53232 0.63879 0.67199 0.65506 PseudoU_synth_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 2 2 2 5.6 5.6 5.6 55.647 2.2734E-13 7231200 3909400 3321700 4202 IPI:IPI00306260.7 tRNA pseudouridine synthase 3;tRNA-uridine isomerase 3;tRNA pseudouridylate synthase 3 PUS3;FKSG32 Q9BZE2 ENST00000227474 1 0.7239 1.6493 0.79017 0.90164 1.1069 1.0435 SUI1 binding;nucleic acid binding;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity cellular process;translational initiation 7 7 7 41.9 41.9 41.9 22.092 1.8717E-66 266320000 143700000 122620000 4203 IPI:IPI00306280.4 Density-regulated protein;Protein DRP1;Smooth muscle cell-associated protein 3 DENR;DRP1;H14 O43583 ENST00000280557 1 0.8226 1.6146 0.88667 1.1186 1.0421 1.1277 Xpo1 cell part;cytoplasm;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;nucleic acid binding;RNA binding;tRNA binding intracellular transport;nuclear export;nucleic acid transport;nucleobase, nucleoside, nucleotide and nucleic acid transport;nucleocytoplasmic transport;RNA export from nucleus;RNA transport;transport;tRNA export from nucleus;tRNA transport 24 24 24 32.4 32.4 32.4 109.96 0 673730000 350270000 323450000 4204 IPI:IPI00306290.5 Exportin-T;tRNA exportin;Exportin(tRNA) XPOT O43592 ENST00000332707 1 0.5196 1.2159 0.60044 0.64699 0.78791 0.79397 Mis14 chromosomal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;macromolecular complex;membrane-bounded organelle;MIS12/MIND type complex;nucleus;organelle;organelle part;protein complex binding;protein binding cell cycle phase;cell cycle process;cell division;cellular component organization;cellular process;chromosome segregation;mitosis;nuclear division;organelle fission;organelle organization 3 3 3 11.7 11.7 11.7 32.162 0.00015856 14353000 8172100 6181400 4205 IPI:IPI00306330.7 Kinetochore-associated protein NSL1 homolog NSL1;C1orf48;DC8;DC31 Q96IY1 ENST00000366977 1 0.73706 1.3331 0.73188 0.96388 0.89473 0.9562 Ribosomal_L24e cell part;cytoplasmic part;cytosolic large ribosomal subunit;cytosolic part;intracellular organelle part;intracellular part;large ribosomal subunit;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit binding;nucleic acid binding;protein binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 6 6 6 29.3 29.3 29.3 17.779 4.1057E-121 5599800000 3004300000 2595500000 4206 IPI:IPI00306332.4 60S ribosomal protein L24;Ribosomal protein L30 RPL24 P83731 ENST00000265264;ENST00000394077 K02896 1 1.2778 1.7743 NaN 1.5839 1.2629 NaN PH cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;nucleus;organelle;plasma membrane binding;lipid binding;phospholipid binding 2 2 2 4.5 4.5 4.5 45.553 3.9922E-15 8292800 4171300 4121500 4207 IPI:IPI00306354.3 Pleckstrin homology domain-containing family A member 1;Tandem PH domain-containing protein 1 PLEKHA1;TAPP1 Q9HB21 ENST00000368990;ENST00000409427 1 0.72608 1.401 0.71945 0.93756 0.93501 0.91228 Nol1_Nop2_Fmu cell part;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;catalytic activity;methyltransferase activity;nucleic acid binding;RNA binding;RNA methyltransferase activity;S-adenosylmethionine-dependent methyltransferase activity;tRNA binding;tRNA methyltransferase activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;one-carbon metabolic process;RNA methylation;RNA processing;tRNA metabolic process;tRNA modification;tRNA processing 27 27 27 43.7 43.7 43.7 86.47 1.3707E-285 1431900000 783260000 648630000 4208 IPI:IPI00306369.3 tRNA (cytosine-5-)-methyltransferase NSUN2;NOL1/NOP2/Sun domain family member 2;tRNA (cytosine-5-)-methyltransferase;tRNA methyltransferase 4 homolog;Substrate of AIM1/Aurora kinase B NSUN2;SAKI;TRM4 Q08J23 ENST00000264670 1 0.84782 1.4847 0.79835 1.0749 1.0061 1.0122 SCAMP cell part;integral to membrane;intrinsic to membrane;membrane part cellular process;establishment of localization;establishment of protein localization;Golgi vesicle transport;intracellular transport;post-Golgi vesicle-mediated transport;protein transport;transport;vesicle-mediated transport 7 7 7 32 32 32 38.287 0 321150000 169400000 151750000 4209 IPI:IPI00306382.2;IPI:IPI00306383.2 Secretory carrier-associated membrane protein 3 SCAMP3;C1orf3;PROPIN1 O14828-1;O14828;O14828-2 ENST00000302631;ENST00000355379 2 0.84402 1.491 0.78898 1.1045 0.97879 0.98974 Kinesin centrosome;early endosome;endosome;intracellular organelle;macromolecular complex;membrane-bounded organelle;microtubule;microtubule associated complex;microtubule organizing center;non-membrane-bounded organelle;nucleus;organelle;spindle ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;microtubule motor activity;motor activity;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity cell cycle process;cell division;cellular component organization;cellular process;chromosome organization;microtubule-based movement;microtubule-based process;mitotic sister chromatid segregation;organelle organization;sister chromatid segregation 9 9 9 20.2 20.2 20.2 73.747 2.0076E-143 72049000 40883000 31166000 4210 IPI:IPI00306400.9 Kinesin-like protein KIFC1;Kinesin-like protein 2;Kinesin-related protein HSET KIFC1;HSET;KNSL2 Q9BW19 ENST00000374523;ENST00000383191 K10405 1 NaN 0.79883 0.56439 NaN 0.5396 0.74741 RIO1;Rio2_N ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cellular biopolymer metabolic process;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process 3 3 3 7.1 7.1 7.1 63.282 2.729E-37 3091700 1589400 1502300 4211 IPI:IPI00306406.4 Serine/threonine-protein kinase RIO2 RIOK2 Q9BVS4 ENST00000283109 K07179 1 1.051 2.0979 1.0783 1.3152 1.4269 1.5625 SCAN;zf-C2H2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transcription factor activity;transcription regulator activity;transcription repressor activity;transition metal ion binding;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 3 3 3 9.2 9.2 9.2 42.155 3.4499E-10 29340000 12295000 17045000 4213 IPI:IPI00306446.2 Zinc finger protein 24;Zinc finger protein 191;Zinc finger protein KOX17;Retinoic acid suppression protein A;RSG-A;Zinc finger and SCAN domain-containing protein 3 ZNF24;KOX17;ZNF191;ZSCAN3 P17028 ENST00000261332;ENST00000399061 K09230 1 NaN 1.5077 0.17096 NaN 0.90206 0.25393 DUF572 5 5 5 24.1 24.1 24.1 37.085 6.6371E-40 13310000 9653100 3656800 4215 IPI:IPI00306471.1 Coiled-coil domain-containing protein 94 CCDC94 Q9BW85 ENST00000262962 1 0.69954 1.4198 0.73982 0.94909 0.9338 0.98 Tim44 cytoplasmic part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;mitochondrial inner membrane presequence translocase complex;mitochondrial matrix;mitochondrial part;organelle part;protein complex ATP binding;binding;nucleoside binding;nucleotide binding;primary active transmembrane transporter activity;protein binding;protein transmembrane transporter activity;protein transporter activity;purine nucleoside binding;transporter activity cellular process;establishment of protein localization;intracellular protein transport;intracellular transport;mitochondrial transport;protein import;protein targeting;protein targeting to mitochondrion;protein transport;transport 17 17 17 36.7 36.7 36.7 51.355 2.3892E-212 506360000 262530000 243830000 4216 IPI:IPI00306516.1 Mitochondrial import inner membrane translocase subunit TIM44 TIMM44;MIMT44;TIM44 O43615 ENST00000270538 1 0.27752 0.52283 0.2709 0.38395 0.32666 0.36393 cell part;chromosome;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle binding;protein binding cell cycle;cellular process;DNA metabolic process;DNA repair;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to DNA damage stimulus;response to stress 20 20 20 16.1 16.1 16.1 149.32 9.1643E-256 200060000 118310000 81752000 4217 IPI:IPI00306518.3;IPI:IPI00019447.6;IPI:IPI00784704.2 Fanconi anemia group I protein FANCI;KIAA1794 Q9NVI1-3;Q9NVI1;Q9NVI1-1;Q9NVI1-2 ENST00000300027;ENST00000310775 K10895 3 0.81675 1.5604 0.81827 1.0434 1.1159 1.0955 SH2;SH3_1 cell part;cytoplasmic part;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle binding;cytoskeletal adaptor activity;cytoskeletal protein binding;molecular adaptor activity;protein binding;protein complex scaffold;receptor signaling complex scaffold activity;structural molecule activity cell activation;immune system process;positive regulation of immune system process;positive regulation of leukocyte activation;protein complex assembly;regulation of immune system process;regulation of leukocyte activation;regulation of translation ErbB signaling pathway;T cell receptor signaling pathway 3 2 2 7.9 5.8 5.8 42.915 2.3801E-14 4731600 2647600 2084000 4218 IPI:IPI00306531.3 Cytoplasmic protein NCK2;NCK adaptor protein 2;SH2/SH3 adaptor protein NCK-beta NCK2 O43639 ENST00000233154;ENST00000393349 K07365 1 0.46094 0.7701 0.4887 0.59582 0.54138 0.59057 Sof1;WD40 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;ribonucleoprotein complex cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 11 11 11 22.4 22.4 22.4 67.55 0 230310000 135240000 95067000 4219 IPI:IPI00306642.3;IPI:IPI00747916.1 WD repeat and SOF domain-containing protein 1 WDSOF1;HSPC064 Q9NV06-1;Q9NV06 ENST00000297579;ENST00000388778 K11806 2 NaN NaN 0.83282 NaN NaN 1.0348 zf-C2H2;ZZ cell part;intracellular binding;catalytic activity;cation binding;ion binding;ligase activity;metal ion binding;transition metal ion binding;zinc ion binding catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 4 4 4 15.2 15.2 15.2 41.945 1.3286E-14 40832000 20374000 20458000 4220 IPI:IPI00306661.3 E3 ubiquitin-protein ligase KCMF1;Potassium channel modulatory factor;FGF-induced in gastric cancer;ZZ-type zinc finger-containing protein 1 KCMF1;FIGC;ZZZ1 Q9P0J7 ENST00000319855;ENST00000409785 1 0.98763 1.4741 NaN 1.2316 1.0407 NaN CN_hydrolase;NAD_synthase cell part;cytoplasmic part;cytosol;intracellular part ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;NAD+ synthase (glutamine-hydrolyzing) activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding coenzyme metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;oxidoreduction coenzyme metabolic process;vitamin metabolic process;water-soluble vitamin metabolic process Glutamate metabolism;Nicotinate and nicotinamide metabolism 5 5 5 5.5 5.5 5.5 79.284 9.9526E-08 8342300 4656200 3686000 4221 IPI:IPI00306689.6 Glutamine-dependent NAD(+) synthetase;NAD(+) synthase [glutamine-hydrolyzing];NAD(+) synthetase 1 NADSYN1 Q6IA69 ENST00000319023 K01950 1 0.61588 1.234 0.63929 0.81423 0.77464 0.8218 Pkinase ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cellular component organization;cellular process;metabolic process;mitosis;nuclear division;organelle organization;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein modification process 10 10 10 32.1 32.1 32.1 37.211 6.5888E-101 199210000 109110000 90100000 4222 IPI:IPI00306708.4 Lymphokine-activated killer T-cell-originated protein kinase;T-LAK cell-originated protein kinase;PDZ-binding kinase;Spermatogenesis-related protein kinase;MAPKK-like protein kinase;Nori-3;Cancer/testis antigen 84 PBK;TOPK Q96KB5 ENST00000301905 K08865 1 0.61548 1.2233 0.67892 0.82596 0.80097 0.92522 CBF cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent 13 13 13 14.3 14.3 14.3 120.99 1.078E-186 160420000 85323000 75095000 4223 IPI:IPI00306723.3 CCAAT/enhancer-binding protein zeta;CCAAT-box-binding transcription factor CEBPZ;CBF2 Q03701 ENST00000234170 1 NaN 1.4992 0.51366 NaN 0.83004 0.66475 ABC_membrane;ABC_tran cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part ATP binding;binding;catalytic activity;heme transporter activity;nucleoside binding;nucleotide binding;primary active transmembrane transporter activity;purine nucleoside binding;transporter activity establishment of localization;transport ABC transporters 6 6 6 7.4 7.4 7.4 82.768 1.3336E-24 58266000 32079000 26188000 4224 IPI:IPI00556553.1;IPI:IPI00306748.1 ATP-binding cassette sub-family B member 7, mitochondrial;ATP-binding cassette transporter 7 ABCB7;ABC7 O75027-2;O75027;O75027-1 ENST00000253577;ENST00000373394 K05662 2 1.0072 1.767 0.94741 1.2644 1.18 1.274 dsrm;FHA cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;double-stranded RNA binding;nucleic acid binding;protein binding;RNA binding 11 11 11 20.1 20.1 20.1 88.813 2.5919E-107 185690000 92745000 92949000 4225 IPI:IPI00306749.8 Kanadaptin;Kidney anion exchanger adapter protein;Solute carrier family 4 anion exchanger member 1 adapter protein;Human lung cancer oncogene 3 protein SLC4A1AP;HLC3 Q9BWU0 ENST00000326019 1 NaN NaN 1.2516 NaN NaN 1.6534 TPD52 binding;protein binding 9 1 1 53.9 6.3 6.3 22.237 2.7711E-158 128940000 60771000 68171000 4226 IPI:IPI00306825.3 Tumor protein D54;Tumor protein D52-like 2 TPD52L2 O43399-1;O43399 ENST00000217121;ENST00000346249;ENST00000348257 1 NaN 1.7379 NaN NaN 1.1773 NaN PAP2 cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part Sphingolipid metabolism 2 2 2 4.5 4.5 4.5 49.107 0.00079486 1933300 1009400 923900 4227 IPI:IPI00306840.2 Sphingosine-1-phosphate phosphatase 1;Sphingosine-1-phosphatase 1 SGPP1 Q9BX95 ENST00000247225 K04716 1 0.91817 NaN NaN 1.298 NaN NaN Ank;SH3_1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding apoptosis;cell death;cellular process;death;induction of apoptosis;induction of programmed cell death;positive regulation of apoptosis;positive regulation of cell death;programmed cell death;regulation of apoptosis;regulation of cell death 2 1 1 2.1 1.4 1.4 119.58 0.0039852 76518 59894 16625 4228 IPI:IPI00306903.8 Apoptosis-stimulating of p53 protein 1;Protein phosphatase 1 regulatory subunit 13B PPP1R13B;ASPP1;KIAA0771 Q96KQ4 ENST00000202556 1 0.97725 1.6441 0.36328 1.1488 1.0131 0.49807 C1_1;IQ;Myosin_head;RA;RhoGAP cell cortex;cell part;cytoplasmic part;cytoskeletal part;filamentous actin;intracellular organelle part;intracellular part;macromolecular complex;myosin complex;organelle part;perinuclear region of cytoplasm;protein complex actin binding;catalytic activity;GTPase activator activity;microfilament motor activity;motor activity;nucleoside binding;nucleotide binding;purine nucleoside binding;Ras GTPase activator activity;small GTPase regulator activity actin filament-based process;cell communication;cellular process;intracellular signaling cascade;Ras protein signal transduction;Rho protein signal transduction;signal transduction;small GTPase mediated signal transduction;transport 5 5 5 3.1 3.1 3.1 243.56 1.2153E-33 799710000 414970000 384740000 4229 IPI:IPI00336047.5;IPI:IPI00306933.2 Myosin-IXb;Unconventional myosin-9b MYO9B;MYR5 Q13459-1;Q13459;Q13459-2 ENST00000319396;ENST00000397274 2 0.30169 0.522 0.28051 0.38159 0.35708 0.35877 WD40 3 3 3 7 7 7 51.727 9.3641E-12 14365000 7647400 6717600 4230 IPI:IPI00306934.4 WD repeat-containing protein 41 WDR41;MSTP048 Q9HAD4 ENST00000296679 1 0.77646 1.4467 0.8314 1.0182 0.98662 1.0663 tRNA_anti;tRNA-synt_2 cell fraction;cell part;cytoplasm;intracellular part;soluble fraction aminoacyl-tRNA ligase activity;asparagine-tRNA ligase activity;aspartate-tRNA ligase activity;ATP binding;binding;catalytic activity;ligase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding asparaginyl-tRNA aminoacylation;aspartyl-tRNA aminoacylation;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;tRNA aminoacylation for protein translation;tRNA metabolic process Alanine and aspartate metabolism;Aminoacyl-tRNA biosynthesis 33 33 33 48 48 48 62.942 0 3041200000 1550300000 1490800000 4231 IPI:IPI00306960.3 Asparaginyl-tRNA synthetase, cytoplasmic;Asparagine--tRNA ligase NARS;ASNS O43776 ENST00000256854 K01893 1 0.47876 1.1543 NaN 0.71206 0.6363 NaN C1_1;HR1;PH;Pkinase;Pkinase_C;Rho_Binding cell part;cytoplasm;intracellular part;membrane;plasma membrane ATP binding;binding;catalytic activity;lipid binding;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;structural molecule activity;zinc ion binding cell communication;cellular process;cytokinesis;intracellular signaling cascade;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein modification process;signal transduction Axon guidance;Chemokine signaling pathway;Focal adhesion;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;TGF-beta signaling pathway;Vascular smooth muscle contraction;Wnt signaling pathway 6 4 4 5.4 4 4 160.9 1.3935E-53 13291000 7722000 5568900 4232 IPI:IPI00307155.8 Rho-associated protein kinase 2;Rho-associated, coiled-coil-containing protein kinase 2;p164 ROCK-2;Rho kinase 2 ROCK2;KIAA0619 O75116 ENST00000315872;ENST00000399089 K04514 1 0.84084 1.2933 0.75943 1.0492 0.85504 0.95416 efhand;GRAM;TBC cell part;integral to membrane;intracellular;intrinsic to membrane;membrane part binding;calcium ion binding;cation binding;enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;ion binding;Rab GTPase activator activity;Ras GTPase activator activity;small GTPase regulator activity biological regulation;regulation of catalytic activity;regulation of GTPase activity;regulation of hydrolase activity;regulation of molecular function;regulation of Rab GTPase activity;regulation of Ras GTPase activity 12 12 12 11.2 11.2 11.2 140.5 1.9455E-36 28245000 15218000 13027000 4233 IPI:IPI00307257.4;IPI:IPI00640908.3;IPI:IPI00848032.1 TBC1 domain family member 9B TBC1D9B;KIAA0676 Q66K14-1;Q66K14;Q66K14-2 ENST00000355235;ENST00000356834 3 0.6583 1.3701 0.73964 0.87585 0.91237 0.96773 DnaJ binding;heat shock protein binding;protein binding 36 36 36 19.2 19.2 19.2 254.43 0 258890000 144490000 114390000 4234 IPI:IPI00307259.11 DnaJ homolog subfamily C member 13;Required for receptor-mediated endocytosis 8 DNAJC13;KIAA0678;RME8 O75165 ENST00000260818 K09533 1 0.96703 1.4133 0.9873 1.2244 0.96095 1.2443 CoA_trans cell part;cell projection;cytoplasmic part;flagellum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;microtubule-based flagellum;mitochondrion;organelle 3-oxoacid CoA-transferase activity;catalytic activity;CoA-transferase activity;transferase activity;transferase activity, transferring sulfur-containing groups catabolic process;cellular catabolic process;cellular ketone body metabolic process;cellular metabolic process;cellular process;ketone body catabolic process;metabolic process Butanoate metabolism;Synthesis and degradation of ketone bodies;Valine, leucine and isoleucine degradation 2 1 1 7.5 5.2 5.2 56.139 4.1126E-20 10068000 5396700 4671200 4236 IPI:IPI00307395.2 Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial;3-oxoacid-CoA transferase 2A;Testis-specific succinyl CoA:3-oxoacid CoA-transferase;SCOT-t OXCT2;FKSG25 Q9BYC2 ENST00000327582 K01028;K01029 1 0.62088 1.5522 0.71832 0.83123 1.0479 0.92518 Ribosomal_L9_N intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;mitochondrial ribosome;non-membrane-bounded organelle;organellar ribosome;organelle;organelle part;ribonucleoprotein complex;ribosome structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 6 6 6 26.2 26.2 26.2 30.243 2.7165E-47 98235000 55147000 43087000 4237 IPI:IPI00307409.6 39S ribosomal protein L9, mitochondrial;MRP-L9 MRPL9 Q9BYD2 ENST00000368830 1 1.1356 1.8232 0.88889 1.4438 1.2613 1.0738 Ras cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane;non-membrane-bounded organelle;organelle;plasma membrane binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleotide binding;pyrophosphatase activity actin filament organization;cell communication;cellular component organization;cellular process;cytoskeleton organization;intracellular signaling cascade;organelle organization;signal transduction;small GTPase mediated signal transduction 3 3 3 19 19 19 23.625 6.3972E-39 24720000 12437000 12283000 4238 IPI:IPI00307458.3;IPI:IPI00382965.3 Rho-related GTP-binding protein RhoF;Rho family GTPase Rif;Rho in filopodia RHOF;ARHF;RIF Q9HBH0-1;Q9HBH0;Q9HBH0-2 ENST00000267205 K07872 2 0.83515 1.2053 0.80643 1.0936 0.79383 1.0375 Methyltransf_11 cell part;cytoplasmic part;cytosol;intracellular part arsenite methyltransferase activity;catalytic activity;methylarsonite methyltransferase activity;methyltransferase activity;S-adenosylmethionine-dependent methyltransferase activity;transferase activity;transferase activity, transferring one-carbon groups arsonoacetate metabolic process;carboxylic acid metabolic process;cellular ketone metabolic process;cellular process;metabolic process;organic acid metabolic process;secondary metabolic process;toxin metabolic process;xenobiotic metabolic process 7 7 7 21.6 21.6 21.6 41.747 3.1805E-25 137580000 70786000 66798000 4239 IPI:IPI00307524.7 Arsenite methyltransferase;S-adenosyl-L-methionine:arsenic(III) methyltransferase;Methylarsonite methyltransferase AS3MT;CYT19 Q9HBK9 ENST00000359508;ENST00000369880 K07755 1 0.93411 1.4153 0.82015 1.227 0.92842 1.0788 DUF2368 cell part;cytoplasmic part;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane part;membrane-bounded organelle;mitochondrion;organelle 3 3 3 21.8 21.8 21.8 17.201 4.2183E-09 58168000 30939000 27228000 4240 IPI:IPI00307547.1 Transmembrane protein C9orf46 C9orf46;AD025;MDS030 Q9HBL7 ENST00000223864 1 0.6872 NaN 0.79652 0.91959 NaN 1.1283 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding 3 3 3 3.3 3.3 3.3 151.19 3.2772E-11 16311000 9204700 7106300 4242 IPI:IPI00307591.5 Zinc finger protein 609 ZNF609;KIAA0295 O15014 ENST00000326648 1 0.79034 1.9456 0.71635 1.0319 1.0852 0.93002 Chromo cell part;chromatin;chromosomal part;intracellular organelle part;intracellular part;organelle part binding;chromatin binding chromatin assembly or disassembly;chromatin organization;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;regulation of transcription, DNA-dependent;transcription 7 7 7 22.4 22.4 22.4 43.395 2.5202E-33 36996000 19730000 17267000 4243 IPI:IPI00307659.2 Chromobox protein homolog 8;Polycomb 3 homolog;Rectachrome 1 CBX8;PC3;RC1 Q9HC52 ENST00000269385 K11455 1 1.1285 1.5928 NaN 1.4253 1.0617 NaN SET;SRI_2;WW cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;DNA binding;methyltransferase activity;N-methyltransferase activity;nucleic acid binding;protein binding;protein methyltransferase activity;S-adenosylmethionine-dependent methyltransferase activity biosynthetic process;chromatin organization;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;regulation of transcription, DNA-dependent;transcription Lysine degradation 6 6 6 2.8 2.8 2.8 287.55 2.5893E-39 6355500 3883300 2472300 4244 IPI:IPI00307733.5;IPI:IPI00796144.1;IPI:IPI00442150.2 Histone-lysine N-methyltransferase SETD2;SET domain-containing protein 2;Huntingtin-interacting protein B;Huntingtin yeast partner B;Huntingtin-interacting protein 1;HIF-1;p231HBP;Lysine N-methyltransferase 3A SETD2;HIF1;HYPB;KIAA1732;KMT3A;SET2;HSPC069 Q9BYW2-1;Q9BYW2;Q9BYW2-2;Q9BYW2-3 ENST00000409792 K11423 3 0.8899 1.6489 0.84499 1.1768 1.0552 1.0769 Oxidored_q6 cytoplasmic part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;mitochondrial membrane part;mitochondrial part;mitochondrial respiratory chain complex I;NADH dehydrogenase complex;organelle part;protein complex binding;catalytic activity;iron ion binding;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;protein binding anatomical structure formation;cellular process;generation of precursor metabolites and energy;metabolic process;mitochondrial electron transport, NADH to ubiquinone;NADH dehydrogenase complex assembly;protein complex assembly;transport Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 6 6 6 22.1 22.1 22.1 32.833 1.8922E-85 188010000 96917000 91093000 4245 IPI:IPI00307749.2 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial;NADH-ubiquinone oxidoreductase 20 kDa subunit;Complex I-20kD;PSST subunit NDUFS7 O75251 ENST00000233627;ENST00000382445 K03940 1 NaN 1.418 NaN NaN 0.90751 NaN Pkinase cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part ATP binding;binding;catalytic activity;kinase activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity alcohol metabolic process;fatty acid biosynthetic process;fatty acid metabolic process;lipid metabolic process;organic acid metabolic process;protein amino acid phosphorylation;protein modification process;steroid biosynthetic process Adipocytokine signaling pathway;Insulin signaling pathway;mTOR signaling pathway;Regulation of autophagy 4 1 1 12 2.9 2.9 62.319 3.4066E-214 663480 408200 255270 4246 IPI:IPI00307755.3 5'-AMP-activated protein kinase catalytic subunit alpha-2 PRKAA2;AMPK;AMPK2 P54646 ENST00000371244 K07198 1 0.86192 1.5774 0.82721 1.1283 1.0339 1.2256 zf-CCCH cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding 5 5 5 21 21 21 33.575 3.2324E-69 41698000 22036000 19661000 4247 IPI:IPI00307760.7 Zinc finger CCCH domain-containing protein 8 ZC3H8;ZC3HDC8 Q8N5P1 ENST00000272570;ENST00000409573 1 0.51646 1.4678 NaN 0.64318 0.98603 NaN HGTP_anticodon;TGS;tRNA_SAD;tRNA-synt_2b cell part;cytoplasm;intracellular part aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-oxygen bonds;nucleoside binding;nucleotide binding;purine nucleoside binding;threonine-tRNA ligase activity cellular amino acid and derivative metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;threonyl-tRNA aminoacylation;tRNA aminoacylation for protein translation;tRNA metabolic process Aminoacyl-tRNA biosynthesis;Glycine, serine and threonine metabolism 8 4 4 10.3 6.1 6.1 92.644 3.7654E-35 2069200 1208900 860310 4248 IPI:IPI00328082.3;IPI:IPI00892711.1 Probable threonyl-tRNA synthetase 2, cytoplasmic;Threonine--tRNA ligase;Threonyl-tRNA synthetase-like protein 2 TARSL2 A2RTX5-1;A2RTX5;A2RTX5-2 ENST00000333018;ENST00000335968 K01868 2 0.92046 1.7498 0.86312 1.3509 1.1394 1.1033 ABC_membrane;ABC_tran cytosol;endoplasmic reticulum lumen;endoplasmic reticulum membrane;integral to membrane;intrinsic to membrane;macromolecular complex;membrane;membrane-bounded organelle;membrane-enclosed lumen;nucleus;organelle;organelle membrane;TAP complex antigen binding;ATP binding;binding;catalytic activity;homoaconitate hydratase activity;nucleoside binding;nucleotide binding;peptide transporter activity;protein binding;purine nucleoside binding;receptor binding;transporter activity antigen processing and presentation of endogenous peptide antigen;antigen processing and presentation of peptide antigen via MHC class I;immune system process;intracellular protein transport;oligopeptide transport;protein complex assembly;transport 3 3 3 5.8 5.8 5.8 75.663 3.0896E-10 38639000 20524000 18115000 4249 IPI:IPI00328112.4 Antigen peptide transporter 2;ATP-binding cassette sub-family B member 3;Peptide transporter TAP2;Peptide supply factor 2;Peptide transporter PSF2;Peptide transporter involved in antigen processing 2 TAP2;ABCB3;PSF2;RING11;Y1 Q03519 ENST00000374897;ENST00000383118;ENST00000383239 1 1.0995 1.9659 1.0567 1.3948 1.2894 1.3147 chromosomal part;condensed chromosome kinetochore;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;kinetochore;macromolecular complex;non-membrane-bounded organelle;organelle;organelle part;protein complex cell communication;cellular process;cytoskeleton organization;intracellular signaling cascade;microtubule cytoskeleton organization;microtubule-based process;mitosis;nuclear division;organelle organization;signal transduction;spindle organization 10 10 10 9.7 9.7 9.7 134.42 4.544E-84 45558000 21816000 23742000 4250 IPI:IPI00328118.4 Sperm-associated antigen 5;Astrin;Mitotic spindle-associated protein p126;Deepest SPAG5 Q96R06 ENST00000321765 1 0.6015 1.1013 0.62551 0.80098 0.75333 0.8599 Peptidase_M1 histone acetyltransferase complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex;transcription factor complex;transcription factor TFIID complex;transcription factor TFTC complex binding;catalytic activity;cation binding;DNA binding;hydrolase activity;ion binding;metal ion binding;metallopeptidase activity;nucleic acid binding;peptidase activity;promoter binding;protein binding;sequence-specific DNA binding;zinc ion binding G2/M transition of mitotic cell cycle;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription initiation;transcription initiation from RNA polymerase II promoter Basal transcription factors 3 3 3 3.6 3.6 3.6 136.97 1.1923E-05 17008000 10049000 6959100 4251 IPI:IPI00328144.6 Transcription initiation factor TFIID subunit 2;Transcription initiation factor TFIID 150 kDa subunit;TBP-associated factor 150 kDa;TAFII-150;150 kDa cofactor of initiator function;RNA polymerase II TBP-associated factor subunit B TAF2;CIF150;TAF2B Q6P1X5 ENST00000378164 K03128 1 0.73341 1.3811 0.72405 0.97747 0.92168 0.98297 E2_bind;ThiF;UBACT cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle acid-amino acid ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;small protein activating enzyme activity catabolic process;cell cycle;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;protein modification process;proteolysis Ubiquitin mediated proteolysis 12 12 12 33.5 33.5 33.5 51.852 0 574930000 307780000 267150000 4252 IPI:IPI00328154.4 NEDD8-activating enzyme E1 catalytic subunit;Ubiquitin-like modifier-activating enzyme 3;NEDD8-activating enzyme E1C;Ubiquitin-activating enzyme E1C UBA3;UBE1C Q8TBC4 ENST00000361055 K10686 1 0.67214 1.3035 0.6731 0.84989 0.91959 0.83726 Glyco_hydro_63 cell fraction;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;insoluble fraction;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane fraction;membrane part;organelle membrane;organelle part catalytic activity;glucosidase activity;hydrolase activity;hydrolase activity, acting on glycosyl bonds;hydrolase activity, hydrolyzing O-glycosyl compounds;mannosyl-oligosaccharide glucosidase activity carbohydrate metabolic process;cellular process;metabolic process;oligosaccharide metabolic process;protein amino acid glycosylation;protein amino acid N-linked glycosylation;protein metabolic process;protein modification process N-Glycan biosynthesis 13 13 13 18.6 18.6 18.6 91.916 1.8537E-165 295180000 148400000 146780000 4253 IPI:IPI00328170.9 Mannosyl-oligosaccharide glucosidase;Processing A-glucosidase I MOGS;GCS1 Q13724 ENST00000233616 K01228 1 0.82848 1.3837 0.9152 1.0123 0.99591 1.1036 DUF2146 binding;protein binding mRNA catabolic process;nuclear-transcribed mRNA catabolic process;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA catabolic process 4 4 4 4.1 4.1 4.1 113.22 4.5803E-05 93489000 47678000 45811000 4254 IPI:IPI00867503.1;IPI:IPI00328183.2;IPI:IPI00847523.2 Protein SMG8;Protein smg-8 homolog;Amplified in breast cancer gene 2 protein SMG8;ABC2;C17orf71 Q8ND04-2;Q8ND04;Q8ND04-1;Q8ND04-3 ENST00000300917 3 NaN 0.70182 0.65615 NaN 0.45476 0.88144 3 3 3 5.7 5.7 5.7 86.435 1.2869E-16 9353000 5414000 3939100 4256 IPI:IPI00328200.3 Glutamine-rich protein 1 QRICH1 Q2TAL8 ENST00000357496;ENST00000395443 1 0.88974 1.802 0.95439 1.3168 1.249 1.1904 PH;Sec7 cell fraction;cell part;cytoplasm;insoluble fraction;intracellular;intracellular part;membrane;membrane fraction;plasma membrane ARF guanyl-nucleotide exchange factor activity;binding;enzyme regulator activity;GTPase regulator activity;guanyl-nucleotide exchange factor activity;nucleoside-triphosphatase regulator activity;protein binding;small GTPase regulator activity cellular process;regulation of ARF protein signal transduction;regulation of cell adhesion;regulation of cell communication;regulation of Ras protein signal transduction;regulation of signal transduction;transport;vesicle-mediated transport 4 4 4 10.1 10.1 10.1 46.412 1.1382E-05 24678000 13586000 11092000 4257 IPI:IPI00478608.3;IPI:IPI00328228.4;IPI:IPI00015228.1;IPI:IPI00910648.2;IPI:IPI00013892.1;IPI:IPI00216718.5;IPI:IPI00395879.2 Cytohesin-1;PH, SEC7 and coiled-coil domain-containing protein 1;SEC7 homolog B2-1;Cytohesin-2;PH, SEC7 and coiled-coil domain-containing protein 2;ARF nucleotide-binding site opener;ARF exchange factor;Cytohesin-3;PH, SEC7 and coiled-coil domain-containing protein 3;ARF nucleotide-binding site opener 3;General receptor of phosphoinositides 1 CYTH1;D17S811E;PSCD1;CYTH2;ARNO;PSCD2;PSCD2L;CYTH3;ARNO3;GRP1;PSCD3 Q15438-1;Q15438;Q15438-2;Q99418-1;Q99418;Q99418-2;O43739-1;O43739;O43739-2 ENST00000262763;ENST00000361101;ENST00000392453;ENST00000325139;ENST00000391881;ENST00000350796;ENST00000396741 7 0.96627 1.7764 0.80685 1.2989 1.087 1.0959 CNH;Vps39_1;Vps39_2 cell part;cytoplasmic part;endosomal part;endosome membrane;intracellular organelle part;intracellular part;late endosome membrane;lysosomal membrane;membrane;organelle membrane;organelle part;vacuolar membrane;vacuolar part enzyme regulator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity;small GTPase regulator activity establishment of localization;establishment of protein localization;protein transport;transport 7 7 7 9.9 9.9 9.9 101.81 8.0947E-15 11872000 6272700 5598900 4258 IPI:IPI00328236.7;IPI:IPI00332744.2 Vam6/Vps39-like protein VPS39;KIAA0770;VAM6 Q96JC1-1;Q96JC1;Q96JC1-2 ENST00000318006;ENST00000348544 2 NaN 1.2297 0.71211 NaN 0.87858 0.87377 PLD_envelope;PLDc cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;lipase activity;phospholipase activity;phospholipase D activity;phosphoric diester hydrolase activity;phosphoric ester hydrolase activity catabolic process;lipid catabolic process;lipid metabolic process;metabolic process;primary metabolic process 4 4 4 9.2 9.2 9.2 54.705 8.534E-12 6883400 3530500 3352900 4259 IPI:IPI00328243.2 Phospholipase D3;Choline phosphatase 3;Phosphatidylcholine-hydrolyzing phospholipase D3;HindIII K4L homolog;Hu-K4 PLD3 Q8IV08 ENST00000356508;ENST00000409281;ENST00000409419;ENST00000409587;ENST00000409735 1 0.89406 1.6701 0.7752 1.1914 1.0612 1.0346 Adaptin_N;Alpha_adaptinC2;B2-adapt-app_C AP-type membrane coat adaptor complex;clathrin adaptor complex;clathrin coated vesicle membrane;coated vesicle membrane;cytoplasmic vesicle membrane;cytosol;Golgi apparatus;macromolecular complex;membrane;organelle;organelle membrane;vesicle membrane binding;protein binding;protein transporter activity;substrate-specific transporter activity;transporter activity cellular component organization;cellular process;endocytosis;establishment of protein localization;intracellular protein transport;intracellular transport;membrane invagination;membrane organization;protein transport;transport;vesicle-mediated transport 31 11 11 31.2 13.4 13.4 104.61 0 401210000 208490000 192720000 4260 IPI:IPI00328257.4;IPI:IPI00413947.1 AP-1 complex subunit beta-1;Adapter-related protein complex 1 subunit beta-1;Adaptor protein complex AP-1 subunit beta-1;Beta-adaptin 1;Beta1-adaptin;Golgi adaptor HA1/AP1 adaptin beta subunit;Clathrin assembly protein complex 1 beta large chain AP1B1;ADTB1;BAM22;CLAPB2 Q10567-1;Q10567;Q10567-2 ENST00000356015;ENST00000357586;ENST00000405198 K12392 2 0.75177 1.7119 0.74424 0.98194 1.091 1.0382 Beach;GRAM;WD40 cell fraction;cell part;cytoplasm;intracellular part;soluble fraction molecular transducer activity;receptor signaling protein activity;signal transducer activity cell communication;cellular metabolic process;cellular process;ceramide metabolic process;lipid metabolic process;membrane lipid metabolic process;metabolic process;primary metabolic process;signal transduction;sphingolipid metabolic process 7 6 6 8.9 8.3 8.3 104.37 2.0466E-86 8845800 4989100 3856700 4261 IPI:IPI00328260.4 Protein FAN;Factor associated with neutral sphingomyelinase activation NSMAF;FAN Q92636 ENST00000038176 1 0.65681 2.4428 NaN 0.80998 1.601 NaN ARID cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 2 2 2 3.9 3.9 3.9 60.636 5.1702E-25 4375200 2756800 1618400 4262 IPI:IPI00328266.4;IPI:IPI00853367.1 AT-rich interactive domain-containing protein 3B;ARID domain-containing protein 3B;Bright-like;Bright and dead ringer protein ARID3B;BDP;DRIL2 Q8IVW6-1;Q8IVW6;Q8IVW6-3 ENST00000346246;ENST00000395077 2 1.5125 2.6659 1.9821 1.9454 1.8715 2.7026 4 4 4 7.4 7.4 7.4 83.517 4.8873E-16 19653000 8416400 11236000 4263 IPI:IPI00328291.4;IPI:IPI00887050.1 Cytoskeleton-associated protein 2-like CKAP2L Q8IYA6-1;Q8IYA6;Q8IYA6-2 ENST00000302450 2 0.82462 2.1653 0.82855 1.1634 1.2437 1.1583 PWI cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear body;nuclear matrix;nuclear part;nuclear speck;nucleoplasm part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;catalytic activity;DNA binding;nucleic acid binding;protein binding;RNA binding;RNA splicing factor activity, transesterification mechanism nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 5 5 5 8.8 8.8 8.8 103.8 4.3252E-38 297430000 156490000 140940000 4264 IPI:IPI00328293.3;IPI:IPI00647720.1 Serine/arginine repetitive matrix protein 1;Ser/Arg-related nuclear matrix protein;SR-related nuclear matrix protein of 160 kDa SRRM1;SRM160 Q8IYB3-2;Q8IYB3;Q8IYB3-1 ENST00000323848;ENST00000374389 2 0.96006 1.7493 0.91948 1.2266 1.1097 1.1981 binding;cation binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding 19 19 19 25.6 25.6 25.6 89.13 1.9995E-241 265030000 120270000 144760000 4265 IPI:IPI00328306.9 Zinc finger CCCH domain-containing protein 11A ZC3H11A;KIAA0663;ZC3HDC11A O75152 ENST00000332127;ENST00000367210;ENST00000367212;ENST00000367214 1 0.74293 1.205 0.82199 0.9422 0.84854 1.0323 ELO cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part biosynthetic process;cellular process;fatty acid biosynthetic process;fatty acid metabolic process;lipid biosynthetic process;lipid metabolic process;metabolic process;organic acid biosynthetic process;organic acid metabolic process Biosynthesis of unsaturated fatty acids 3 3 3 16.4 16.4 16.4 35.293 3.0172E-69 396170000 209320000 186850000 4266 IPI:IPI00328307.7 Elongation of very long chain fatty acids protein 5 ELOVL5;ELOVL2;PRO0530 Q9NYP7 ENST00000304434;ENST00000370918 K10244 1 0.75949 1.3584 0.76581 0.98495 0.8952 0.99569 WD40 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding chromatin organization;chromatin remodeling;DNA metabolic process;DNA replication;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 14 14 9 54.8 54.8 46.1 47.655 9.8443E-211 4572500000 2443700000 2128800000 4267 IPI:IPI00328319.8 Histone-binding protein RBBP4;Retinoblastoma-binding protein 4;Retinoblastoma-binding protein p48;Chromatin assembly factor 1 subunit C;Chromatin assembly factor I p48 subunit;CAF-I 48 kDa subunit;CAF-I p48;Nucleosome-remodeling factor subunit RBAP48 RBBP4;RBAP48 Q09028 ENST00000373493 1 0.77213 1.6011 0.81344 1.0923 0.98774 1.1317 DEAD;Helicase_C cell part;cytoplasmic part;cytosol;eukaryotic translation initiation factor 4F complex;intracellular part;macromolecular complex;protein complex ATP binding;ATP-dependent helicase activity;binding;catalytic activity;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;RNA binding;translation initiation factor activity biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;regulation of biosynthetic process;regulation of gene expression;regulation of translation;regulation of translational initiation;translation 29 14 14 53.7 25.7 25.7 46.489 0 1046400000 542660000 503750000 4268 IPI:IPI00409717.1;IPI:IPI00328328.3 Eukaryotic initiation factor 4A-II;ATP-dependent RNA helicase eIF4A-2 EIF4A2;DDX2B;EIF4F Q14240-2;Q14240;Q14240-1 ENST00000323963 K03257 2 1.0168 2.1744 0.6687 1.3231 1.4112 0.87908 cell part;cytoplasm;intracellular part negative regulation of protein amino acid phosphorylation;positive regulation of protein amino acid phosphorylation;regulation of biosynthetic process;regulation of protein amino acid phosphorylation;regulation of translation;response to stress 6 6 6 7.3 7.3 7.3 103.13 8.2723E-61 43583000 24894000 18689000 4269 IPI:IPI00328350.6 Protein Niban;Protein FAM129A;Cell growth-inhibiting gene 39 protein FAM129A;C1orf24;NIBAN;GIG39 Q9BZQ8 ENST00000367511 1 0.821 1.6958 0.80406 1.0348 1.1547 1.0243 Seryl_tRNA_N;tRNA-synt_2b cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-oxygen bonds;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;serine-tRNA ligase activity cellular amino acid and derivative metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;seryl-tRNA aminoacylation;tRNA aminoacylation for protein translation;tRNA metabolic process Aminoacyl-tRNA biosynthesis;Glycine, serine and threonine metabolism 11 11 11 26.8 26.8 26.8 58.282 4.0822E-171 83188000 44262000 38925000 4270 IPI:IPI00328361.7 Seryl-tRNA synthetase, mitochondrial;Seryl-tRNA(Ser/Sec) synthetase;Serine--tRNA ligase;SerRSmt SARS2;SARSM Q9NP81 ENST00000221431 K01875 1 0.83488 2.2661 NaN 1.0373 1.4503 NaN Glycos_transf_2;Ricin_B_lectin cell part;cytoplasmic part;Golgi apparatus part;Golgi membrane;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part acetylgalactosaminyltransferase activity;binding;calcium ion binding;catalytic activity;polypeptide N-acetylgalactosaminyltransferase activity;sugar binding;transferase activity;UDP-glycosyltransferase activity carbohydrate metabolic process;cellular biopolymer metabolic process;cellular process;metabolic process;protein amino acid glycosylation;protein amino acid O-linked glycosylation;protein metabolic process;protein modification process O-Glycan biosynthesis 3 3 3 4.6 4.6 4.6 75.388 5.815E-06 4609600 2378000 2231600 4271 IPI:IPI00328391.3 N-acetylgalactosaminyltransferase 7;Polypeptide GalNAc transferase 7;Protein-UDP acetylgalactosaminyltransferase 7;UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7 GALNT7 Q86SF2 ENST00000265000 K00710 1 0.76733 1.6427 0.93438 1.0224 1.0934 1.2659 FAD_binding_6;NAD_binding_1 endoplasmic reticulum membrane;hemoglobin complex;intracellular part;macromolecular complex;membrane;mitochondrial membrane;mitochondrial outer membrane;organelle membrane;organelle outer membrane;organelle part;outer membrane;protein complex catalytic activity;cytochrome-b5 reductase activity;electron carrier activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor alcohol metabolic process;blood circulation;cholesterol biosynthetic process;cholesterol metabolic process;circulatory system process;lipid metabolic process;metabolic process;steroid biosynthetic process;steroid metabolic process;system process Aminosugars metabolism 12 12 12 49.7 49.7 49.7 38.226 3.5419E-130 866430000 450850000 415580000 4272 IPI:IPI00328415.12;IPI:IPI00446235.2 NADH-cytochrome b5 reductase 3;Diaphorase-1;NADH-cytochrome b5 reductase 3 membrane-bound form;NADH-cytochrome b5 reductase 3 soluble form CYB5R3;DIA1 P00387-1;P00387;P00387-2 ENST00000352397;ENST00000361740;ENST00000396303;ENST00000396309 K00326 2 0.71207 1.6011 0.8477 0.88967 0.96693 1.0722 DUF1445 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle 3 3 3 6.6 6.6 6.6 66.926 1.4803E-44 15943000 8310900 7632500 4273 IPI:IPI00411520.1;IPI:IPI00328650.5;IPI:IPI00328443.1;IPI:IPI00411523.1;IPI:IPI00411522.1 UPF0317 protein C14orf159, mitochondrial C14orf159;UNQ2439/PRO5000 Q7Z3D6-2;Q7Z3D6;Q7Z3D6-1;Q7Z3D6-3;Q7Z3D6-5;Q7Z3D6-4 ENST00000256324;ENST00000298858;ENST00000321157;ENST00000336843 5 4.8152 1.8183 NaN 6.071 1.2848 NaN Alpha-mann_mid;Glyco_hydro_38;Glyco_hydro_38C extracellular region alpha-mannosidase activity;binding;carbohydrate binding;catalytic activity;hydrolase activity;hydrolase activity, acting on glycosyl bonds;hydrolase activity, hydrolyzing O-glycosyl compounds;ion binding;mannosidase activity;zinc ion binding alcohol metabolic process;carbohydrate metabolic process;hexose metabolic process;mannose metabolic process;metabolic process;monosaccharide metabolic process;primary metabolic process Other glycan degradation 6 6 6 7.2 7.2 7.2 113.89 1.6657E-73 14374000 3669500 10704000 4274 IPI:IPI00328488.6;IPI:IPI00604401.1 Epididymis-specific alpha-mannosidase;Mannosidase alpha class 2B member 2 MAN2B2;KIAA0935 Q9Y2E5-1;Q9Y2E5;Q9Y2E5-2 ENST00000285599 K12312 2 0.65822 1.2823 0.75043 0.89791 0.85919 1.0167 SPRY cell part;histone methyltransferase complex;intracellular organelle part;intracellular part;macromolecular complex;methyltransferase complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transcription regulator activity;transition metal ion binding;zinc ion binding metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent 5 5 5 10.8 10.8 10.8 68.722 3.3038E-108 49834000 28125000 21709000 4278 IPI:IPI00328658.3;IPI:IPI00333837.1;IPI:IPI00328659.1 Set1/Ash2 histone methyltransferase complex subunit ASH2;ASH2-like protein ASH2L;ASH2L1 Q9UBL3-1;Q9UBL3;Q9UBL3-3;Q9UBL3-2 ENST00000250635;ENST00000343823 3 0.85245 1.5879 0.95809 1.1088 1.0571 1.233 MBT;SAM_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;transcription factor activity;transcription regulator activity biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 9 9 9 19.9 19.9 19.9 77.256 6.1677E-187 57280000 27440000 29839000 4279 IPI:IPI00328688.3;IPI:IPI00472996.1 Sex comb on midleg-like protein 2 SCML2 Q9UQR0-1;Q9UQR0 ENST00000251900;ENST00000398048 K11465 2 0.78354 1.7291 0.80598 1.0962 1.114 1.0711 cell junction;cell-cell junction;endoplasmic reticulum membrane;integral to membrane;intracellular organelle;intrinsic to membrane;membrane;non-membrane-bounded organelle;nuclear membrane;nucleolus;organelle;organelle membrane;tight junction binding;NF-kappaB binding;protein binding;transcription factor binding negative regulation of biosynthetic process;negative regulation of transcription from RNA polymerase II promoter;regulation of biosynthetic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent 11 11 11 25.8 25.8 25.8 63.836 1.2806E-188 647810000 348200000 299610000 4280 IPI:IPI00328715.4 Protein LYRIC;Lysine-rich CEACAM1 co-isolated protein;3D3/LYRIC;Metastasis adhesion protein;Astrocyte elevated gene-1 protein MTDH;AEG1;LYRIC Q86UE4 ENST00000336273 1 0.66734 1.1867 0.64982 0.84037 0.84604 0.8182 cell part;intracellular binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding 19 19 19 26.8 26.8 26.8 98.636 3.1273E-219 321050000 170100000 150950000 4281 IPI:IPI00328737.2;IPI:IPI00787519.1;IPI:IPI00513712.3;IPI:IPI00787098.1 Zinc finger protein 598 ZNF598 Q86UK7-1;Q86UK7;Q86UK7-3;Q86UK7-2 ENST00000248125 4 0.78152 1.7573 0.78278 1.0615 1.0976 1.0752 cell fraction;endoplasmic reticulum membrane;insoluble fraction;integral to membrane;integral to plasma membrane;intracellular part;intrinsic to membrane;intrinsic to plasma membrane;membrane;membrane fraction;organelle membrane;organelle part cellular process;microtubule-based movement;microtubule-based process 38 38 38 33.5 33.5 33.5 156.27 0 894860000 468960000 425900000 4283 IPI:IPI00328753.1;IPI:IPI00337736.1 Kinectin;Kinesin receptor;CG-1 antigen KTN1;CG1;KIAA0004 Q86UP2-1;Q86UP2;Q86UP2-2 ENST00000356229;ENST00000395309 2 0.97991 0.87176 0.95287 1.1483 0.59114 1.1734 HLH coated vesicle membrane;cytoplasmic vesicle membrane;endoplasmic reticulum membrane;ER to Golgi transport vesicle membrane;Golgi membrane;Golgi-associated vesicle membrane;integral to membrane;membrane;nucleus;transport vesicle membrane;vesicle membrane binding;DNA binding;nucleic acid binding;protein binding;RNA polymerase II transcription factor activity;transcription regulator activity alcohol metabolic process;lipid metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 2 2 2 2.1 2.1 2.1 123.69 0.00030812 82152000 43633000 38519000 4284 IPI:IPI00328793.3 Sterol regulatory element-binding protein 2;Sterol regulatory element-binding transcription factor 2;Processed sterol regulatory element-binding protein 2 SREBF2;SREBP2 Q12772 ENST00000361204 K09107 1 0.69875 1.4208 0.68065 0.89956 0.87278 0.89716 UCH cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle catalytic activity;cysteine-type peptidase activity;hydrolase activity;hydrolase activity, acting on ester bonds;peptidase activity;peptidase activity, acting on L-amino acid peptides;thiolester hydrolase activity;ubiquitin thiolesterase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process 8 8 8 9 9 9 120.52 1.7889E-166 156010000 86017000 69998000 4285 IPI:IPI00328815.3;IPI:IPI00786950.1;IPI:IPI00787034.1;IPI:IPI00748485.2;IPI:IPI00414817.4;IPI:IPI00787461.1 Ubiquitin carboxyl-terminal hydrolase 48;Ubiquitin thioesterase 48;Ubiquitin-specific-processing protease 48;Deubiquitinating enzyme 48 USP48;USP31 Q86UV5-1;Q86UV5;Q86UV5-2;Q86UV5-3;Q86UV5-5 ENST00000308271;ENST00000400301 K11858 6 0.81546 1.3515 0.81815 1.002 0.96852 1.029 RRM_1 cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 8 8 8 44.7 44.7 44.7 27.557 4.8545E-280 3144900000 1617400000 1527500000 4286 IPI:IPI00328840.9 THO complex subunit 4;Ally of AML-1 and LEF-1;Transcriptional coactivator Aly/REF;bZIP-enhancing factor BEF THOC4;ALY;BEF Q86V81 ENST00000331204 1 0.3658 NaN NaN 0.49096 NaN NaN Pkinase_Tyr;SH2;SH3_1 caveola;cell part;cytoplasmic part;cytosol;intracellular part;membrane part;membrane raft;plasma membrane part binding;catalytic activity;non-membrane spanning protein tyrosine kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein tyrosine kinase activity;purine nucleoside binding;SH3/SH2 adaptor activity;signal transducer activity cell communication;cellular process;intracellular signaling cascade;protein complex assembly;protein kinase cascade;Ras protein signal transduction;signal complex assembly;signal transduction;small GTPase mediated signal transduction Adherens junction;Epithelial cell signaling in Helicobacter pylori infection;ErbB signaling pathway;Focal adhesion;Gap junction;GnRH signaling pathway;Tight junction;VEGF signaling pathway 7 4 4 14.4 9 9 60.588 1.3334E-39 2208700 1284100 924660 4287 IPI:IPI00328867.6;IPI:IPI00641230.2;IPI:IPI00013981.4;IPI:IPI00646510.2;IPI:IPI00298625.2;IPI:IPI00029769.6;IPI:IPI00432416.4 Proto-oncogene tyrosine-protein kinase Src;pp60c-src;Proto-oncogene tyrosine-protein kinase Yes;p61-Yes;c-Yes SRC;SRC1;YES1;YES P12931-2;P12931;P12931-1;P07947 ENST00000358208;ENST00000360723;ENST00000373567;ENST00000373578;ENST00000314574;ENST00000359834 K05704;K05705 7 0.70866 1.7026 0.87684 0.90496 1.2009 1.1083 PX binding;lipid binding;phosphoinositide binding;phospholipid binding;protein binding cell communication;cellular process 3 3 3 7.9 7.9 7.9 42.78 3.0792E-07 26404000 13845000 12559000 4288 IPI:IPI00328868.3 HCLS1-binding protein 3;HS1-binding protein 3;HSP1BP-3 HS1BP3 Q53T59 ENST00000304031 1 0.60633 1.1364 0.51129 0.84595 0.77323 0.69757 Ank;HECT;MIB_HERC2;Sad1_UNC cell part;intracellular acid-amino acid ligase activity;binding;catalytic activity;cation binding;ion binding;ligase activity;ligase activity, forming carbon-nitrogen bonds;metal ion binding;small conjugating protein ligase activity;ubiquitin-protein ligase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;protein modification process;protein ubiquitination;proteolysis 21 21 21 9 9 9 289.59 8.7649E-119 141880000 81430000 60446000 4289 IPI:IPI00328911.2 E3 ubiquitin-protein ligase HECTD1;HECT domain-containing protein 1;E3 ligase for inhibin receptor;EULIR HECTD1;KIAA1131 Q9ULT8 ENST00000261312 K12231 1 0.77903 1.5653 0.85201 1.0068 1.0944 1.0057 EAP30 cell part;cytoplasmic part;endosome;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;late endosome;membrane-bounded organelle;nucleus;organelle binding;lipid binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription;transport 5 5 5 15.3 15.3 15.3 43.816 1.1916E-12 39522000 21302000 18220000 4290 IPI:IPI00328932.5;IPI:IPI00646971.1 Vacuolar protein-sorting-associated protein 36;ESCRT-II complex subunit VPS36;ELL-associated protein of 45 kDa VPS36;C13orf9;EAP45;CGI-145 Q86VN1-1;Q86VN1;Q86VN1-2 ENST00000378060 K12190 2 0.6684 1.196 NaN 0.84574 0.7803 NaN zf-C3HC4 cell part;intracellular binding;catalytic activity;cation binding;enzyme binding;ion binding;kinase binding;ligase activity;metal ion binding;protein binding;protein kinase binding;transition metal ion binding;zinc ion binding catabolic process;cell communication;cell surface receptor linked signal transduction;cellular process;macromolecule catabolic process;metabolic process;protein metabolic process;proteolysis;signal transduction;Wnt receptor signaling pathway 2 2 2 13.9 13.9 13.9 28.192 2.8121E-16 5942400 3233300 2709100 4291 IPI:IPI00328938.4;IPI:IPI00012239.4 E3 ubiquitin-protein ligase RNF138;RING finger protein 138;Nemo-like kinase-associated RING finger protein RNF138;NARF;HSD4;HSD-4 Q8WVD3-1;Q8WVD3;Q8WVD3-2 ENST00000257190;ENST00000261593;ENST00000399230 K10668 2 0.78308 1.2314 0.78352 1.0102 0.85709 0.98517 WD40 11 11 11 39.9 39.9 39.9 37.535 4.0641E-296 262520000 139980000 122540000 4292 IPI:IPI00328985.1;IPI:IPI00641826.1;IPI:IPI00301252.2 THO complex subunit 6 homolog;WD repeat-containing protein 58 THOC6;WDR58;PSEC0006 Q86W42-1;Q86W42;Q86W42-2;Q86W42-3 ENST00000253952;ENST00000326266 3 0.41228 0.72617 0.40692 0.53309 0.48449 0.51847 Bystin cell part;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part biological adhesion;cell adhesion;cellular component biogenesis;cellular process;female pregnancy;multi-organism process;reproductive process;ribonucleoprotein complex biogenesis;ribosome biogenesis 18 18 18 47.4 47.4 47.4 49.601 0 761270000 429630000 331640000 4293 IPI:IPI00328987.3 Bystin BYSL Q13895 ENST00000230340 1 0.7903 1.5353 0.59245 1.0549 1.0631 0.78104 7tm_1 cell part;integral to membrane;intrinsic to membrane;membrane;membrane part;plasma membrane G-protein coupled receptor activity;nucleotide receptor activity;nucleotide receptor activity, G-protein coupled;purinergic nucleotide receptor activity;receptor activity;signal transducer activity;transmembrane receptor activity biological regulation;cell communication;cell surface receptor linked signal transduction;cellular process;G-protein coupled receptor protein signaling pathway;regulation of biological process;regulation of cellular process;signal transduction Neuroactive ligand-receptor interaction 2 2 2 8.6 8.6 8.6 40.635 4.8919E-14 15814000 8805400 7008800 4297 IPI:IPI00329027.1 P2Y purinoceptor 8 P2RY8 Q86VZ1 ENST00000381297 K08386 1 0.64179 1.106 0.75774 0.80141 0.77357 0.93002 Ribosomal_S39 intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;mitochondrion;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome 2 2 2 16.5 16.5 16.5 18.325 2.6357E-06 90044000 48844000 41201000 4298 IPI:IPI00329036.2 39S ribosomal protein L50, mitochondrial MRPL50 Q8N5N7 ENST00000374865 1 0.81522 NaN 0.7768 1.0911 NaN 1.028 Microtub_assoc centrosome;cytoplasmic part;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;microtubule organizing center;non-membrane-bounded organelle;organelle;organelle part binding;cytoskeletal protein binding;enzyme binding;kinase binding;microtubule binding;neuronal Cdc2-like kinase binding;protein binding;protein kinase binding;tubulin binding anatomical structure development;brain development;developmental process;organ development;regulation of biological process;regulation of cell differentiation;regulation of neurogenesis;regulation of neuron differentiation 3 2 2 1.5 1.2 1.2 215.02 0.0016542 4280000 2331200 1948800 4299 IPI:IPI00329038.5;IPI:IPI00384417.2;IPI:IPI00329039.4;IPI:IPI00384418.3 CDK5 regulatory subunit-associated protein 2;CDK5 activator-binding protein C48;Centrosome-associated protein 215 CDK5RAP2;CEP215;KIAA1633 Q96SN8-1;Q96SN8;Q96SN8-3;Q96SN8-2;Q96SN8-4 ENST00000349780;ENST00000359309;ENST00000360190;ENST00000360822 4 NaN 1.2003 NaN NaN 0.83106 NaN FYVE binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding 4 4 4 10.4 10.4 10.4 51.53 2.3256E-09 7274500 3801100 3473300 4300 IPI:IPI00386862.5;IPI:IPI00329053.3;IPI:IPI00102875.6 Zinc finger FYVE domain-containing protein 19;MLL partner containing FYVE domain ZFYVE19;MPFYVE Q96K21-1;Q96K21;Q96K21-2;Q96K21-3 ENST00000299173;ENST00000336455;ENST00000355341 3 0.78365 1.9775 NaN 1.0664 1.2794 NaN OSTMP1 cell part;integral to membrane;intrinsic to membrane;membrane part 2 2 2 7.8 7.8 7.8 37.256 6.6243E-68 10309000 5769600 4539100 4301 IPI:IPI00329054.1 Osteopetrosis-associated transmembrane protein 1 OSTM1;GL;HSPC019;UNQ6098/PRO21201 Q86WC4 ENST00000193322 1 0.50607 1.1005 0.47287 0.66433 0.70752 0.64145 F-box catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 2 2 2 3.2 3.2 3.2 88.34 3.7898E-20 14942000 8516200 6425500 4302 IPI:IPI00329057.8;IPI:IPI00386731.3;IPI:IPI00336170.5;IPI:IPI00552588.1 F-box/LRR-repeat protein 18;F-box and leucine-rich repeat protein 18 FBXL18;FBL18 Q96ME1-1;Q96ME1;Q96ME1-4;Q96ME1-2;Q96ME1-3 ENST00000312577;ENST00000382368;ENST00000399530 K10284 4 0.65716 1.1665 0.63804 0.86401 0.74006 0.7931 Helicase_C;SNF2_N cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;ATP-dependent helicase activity;binding;catalytic activity;DNA binding;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity 15 15 15 21 21 21 101 2.597E-144 168950000 91283000 77666000 4303 IPI:IPI00329088.4;IPI:IPI00890729.1;IPI:IPI00890749.1;IPI:IPI00854584.1 Chromodomain-helicase-DNA-binding protein 1-like;Amplified in liver cancer protein 1 CHD1L;ALC1 Q86WJ1-1;Q86WJ1;Q86WJ1-2;Q86WJ1-4;Q86WJ1-3 ENST00000369258;ENST00000369259 4 NaN 0.79725 NaN NaN 0.56962 NaN cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part mRNA processing;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA processing;RNA splicing, via endonucleolytic cleavage and ligation;tRNA metabolic process;tRNA splicing, via endonucleolytic cleavage and ligation 3 3 3 8.6 8.6 8.6 58.819 4.3382E-10 2982100 1738000 1244100 4304 IPI:IPI00329143.1;IPI:IPI00429119.1 tRNA-splicing endonuclease subunit Sen54;tRNA-intron endonuclease Sen54 TSEN54;SEN54 Q7Z6J9-1;Q7Z6J9;Q7Z6J9-2 ENST00000333213 2 0.9579 1.9771 1.1381 1.3485 1.2954 1.516 3 3 3 11.6 11.6 11.6 25.282 3.793E-38 66723000 34799000 31924000 4305 IPI:IPI00329147.5 Coiled-coil domain-containing protein 43 CCDC43 Q96MW1 ENST00000315286 1 0.66287 1.3973 0.68611 0.86266 0.88177 0.92392 C2;PH;PI-PLC-X;PI-PLC-Y;SH2;SH3_1 cell part;membrane;plasma membrane binding;calcium ion binding;catalytic activity;inositol or phosphatidylinositol phosphodiesterase activity;phosphoinositide phospholipase C activity;phospholipase activity;phospholipase C activity;protein binding;signal transducer activity catabolic process;cell communication;cellular process;intracellular signaling cascade;lipid catabolic process;lipid metabolic process;metabolic process;phospholipid catabolic process;phospholipid metabolic process;signal transduction Calcium signaling pathway;Epithelial cell signaling in Helicobacter pylori infection;ErbB signaling pathway;Fc epsilon RI signaling pathway;Glioma;Inositol phosphate metabolism;Leukocyte transendothelial migration;Natural killer cell mediated cytotoxicity;Non-small cell lung cancer;Pathways in cancer;Phosphatidylinositol signaling system;VEGF signaling pathway;Vibrio cholerae infection 10 10 10 8.5 8.5 8.5 147.87 3.0615E-40 27858000 15634000 12224000 4306 IPI:IPI00329185.5 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2;Phosphoinositide phospholipase C;Phospholipase C-gamma-2;PLC-IV PLCG2 P16885 ENST00000359376 K05859 1 0.77502 1.3922 0.66933 1.028 0.87009 0.94989 DNA_methylase;PWWP cell part;chromatin;chromosomal part;cytoplasm;euchromatin;intracellular organelle part;intracellular part;nuclear matrix;nuclear part;organelle part binding;catalytic activity;DNA (cytosine-5-)-methyltransferase activity;DNA binding;DNA-methyltransferase activity;methyltransferase activity;nucleic acid binding;protein binding;S-adenosylmethionine-dependent methyltransferase activity;zinc ion binding cellular process;DNA alkylation;DNA metabolic process;DNA methylation;DNA modification;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;one-carbon metabolic process Methionine metabolism 5 5 5 7.3 7.3 7.3 101.86 6.0448E-19 12185000 6238600 5945900 4307 IPI:IPI00329216.3;IPI:IPI00893229.1 DNA (cytosine-5)-methyltransferase 3A;DNA methyltransferase HsaIIIA DNMT3A Q9Y6K1-1;Q9Y6K1;Q9Y6K1-2 ENST00000264709;ENST00000321117;ENST00000380746;ENST00000380756 K00558 2 NaN 1.9574 NaN NaN 1.1676 NaN cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part cellular metabolic process;cellular process;electron transport chain;establishment of localization;generation of precursor metabolites and energy;metabolic process;oxidation reduction;transport Oxidative phosphorylation 2 2 2 24.1 24.1 24.1 14.852 5.2057E-36 3516400 2086100 1430300 4309 IPI:IPI00329301.3;IPI:IPI00893857.1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11;NADH-ubiquinone oxidoreductase subunit B14.7;Complex I-B14.7 NDUFA11 Q86Y39-1;Q86Y39;Q86Y39-2 ENST00000308961 K03956 2 0.76516 1.7921 0.74258 0.93159 1.1609 0.95481 5 5 5 54.8 54.8 54.8 11.955 1.8862E-54 201700000 108910000 92796000 4310 IPI:IPI00329321.3 LYR motif-containing protein 7 LYRM7;C5orf31 Q5U5X0 ENST00000334031 1 0.72268 1.6377 NaN 0.96119 1.1709 NaN SNARE;Syntaxin cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;endocytic vesicle;Golgi apparatus;integral to membrane;intracellular organelle;intrinsic to membrane;membrane-bounded organelle;membrane-bounded vesicle;organelle;vesicle binding;protein binding;SNAP receptor activity cellular process;intracellular protein transport;lipid transport;metabolic process;posttranscriptional regulation of gene expression;protein transport;regulation of gene expression;sterol transport;transport;vesicle-mediated transport SNARE interactions in vesicular transport 4 4 4 20.3 20.3 20.3 31.642 4.7773E-108 7586000 4020500 3565500 4311 IPI:IPI00329332.1 Syntaxin-12 STX12 Q86Y82 ENST00000373939;ENST00000373943 K08488 1 1.0893 1.9824 1.179 1.5143 1.3547 1.4369 CTP_transf_2 cell fraction;cell part;cytoplasmic part;cytosol;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle;soluble fraction catalytic activity;choline-phosphate cytidylyltransferase activity;cytidylyltransferase activity;nucleotidyltransferase activity;transferase activity;transferase activity, transferring phosphorus-containing groups alcohol metabolic process;biogenic amine metabolic process;cellular amino acid and derivative metabolic process;cellular amino acid derivative metabolic process;glycerophospholipid metabolic process;lipid metabolic process;phospholipid metabolic process Aminophosphonate metabolism;Glycerophospholipid metabolism 5 5 5 17.7 17.7 17.7 41.731 2.2689E-15 21842000 11470000 10372000 4312 IPI:IPI00329338.3;IPI:IPI00001562.1;IPI:IPI00640025.3;IPI:IPI00219338.1 Choline-phosphate cytidylyltransferase A;Phosphorylcholine transferase A;CTP:phosphocholine cytidylyltransferase A;CCT-alpha;Choline-phosphate cytidylyltransferase B;Phosphorylcholine transferase B;CTP:phosphocholine cytidylyltransferase B;CCT-beta PCYT1A;CTPCT;PCYT1;PCYT1B;CCTB P49585;Q9Y5K3-1;Q9Y5K3;Q9Y5K3-3;Q9Y5K3-2 ENST00000292823;ENST00000356768;ENST00000379144 K00968 4 1.0383 0.60276 NaN 1.3655 0.42812 NaN DUF1387 cell part;cytoplasm;intracellular part 3 3 3 7.9 7.9 7.9 59.544 4.96E-36 2846200 1570200 1276000 4313 IPI:IPI00329345.7 Spermatogenesis-associated serine-rich protein 2;Serine-rich spermatocytes and round spermatid 59 kDa protein;P59SCR. SPATS2;SCR59;SPATA10;Nbla00526 Q86XZ4 ENST00000321898 1 NaN NaN 0.60775 NaN NaN 0.84196 Cna_B cell part;integral to membrane;intrinsic to membrane;membrane part binding;carbohydrate binding;protein binding 16 1 1 16.9 1.4 1.4 134.35 8.0744E-154 17347000 9455500 7891700 4314 IPI:IPI00329352.3 Nodal modulator 1;pM5 NOMO1;PM5 Q15155 ENST00000287667 1 0.85594 1.2425 0.89483 1.1499 0.79336 1.0922 binding;protein binding 3 3 3 31.4 31.4 31.4 13.087 1.1065E-13 159900000 82992000 76911000 4315 IPI:IPI00329373.3 Protein QIL1;Protein P117 QIL1;C19orf70 Q5XKP0 ENST00000309324 1 0.64266 1.151 0.81497 0.91297 0.82826 1.1459 Myotub-related cell part;cytoplasm;envelope;intracellular organelle part;intracellular part;nuclear envelope;nuclear part;organelle envelope;organelle part calcium activated cation channel activity;catalytic activity;cation channel activity;ion channel activity;phosphoprotein phosphatase activity;protein serine/threonine phosphatase activity;protein tyrosine phosphatase activity;transporter activity cellular biopolymer metabolic process;cellular process;dephosphorylation;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid dephosphorylation;protein metabolic process;protein modification process Aminosugars metabolism;Fructose and mannose metabolism;Riboflavin metabolism;Thiamine metabolism 7 7 7 15.5 15.5 15.5 71.953 7.109E-36 18735000 9926300 8809100 4316 IPI:IPI00329385.4;IPI:IPI00923409.1 Myotubularin-related protein 6 MTMR6 Q9Y217-1;Q9Y217;Q9Y217-2 ENST00000381801 K01112 2 0.62494 1.3113 0.73279 0.83359 0.84688 0.98728 Ribosomal_L6e;Ribosomal_L6e_N cell part;cytoplasmic part;cytosolic large ribosomal subunit;cytosolic part;intracellular organelle part;intracellular part;large ribosomal subunit;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit binding;DNA binding;nucleic acid binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;regulation of biosynthetic process;regulation of gene expression;regulation of transcription, DNA-dependent;translational elongation Ribosome 17 17 17 47.9 47.9 47.9 32.728 1.4544E-253 7939000000 4151700000 3787300000 4317 IPI:IPI00329389.8 60S ribosomal protein L6;TAX-responsive enhancer element-binding protein 107;Neoplasm-related protein C140 RPL6;TXREB1 Q02878 ENST00000202773 K02934 1 NaN 1.5479 NaN NaN 0.95993 NaN PAP2 integral to endoplasmic reticulum membrane;integral to membrane;integral to organelle membrane;intracellular part;intrinsic to endoplasmic reticulum membrane;intrinsic to membrane;intrinsic to organelle membrane;membrane part;organelle part catalytic activity;dolichyldiphosphatase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;pyrophosphatase activity carbohydrate metabolic process;cellular biopolymer metabolic process;cellular process;metabolic process;protein amino acid glycosylation;protein amino acid N-linked glycosylation;protein metabolic process;protein modification process 2 2 2 13.4 13.4 13.4 27.03 1.0841E-24 1423600 845490 578110 4318 IPI:IPI00329410.1 Dolichyldiphosphatase 1;Dolichyl pyrophosphate phosphatase 1 DOLPP1 Q86YN1 ENST00000372546 1 1.2812 2.1162 1.1861 1.7781 1.3407 1.563 Ras cell part;membrane;plasma membrane binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cell communication;cellular process;establishment of protein localization;intracellular signaling cascade;protein transport;regulation of biological process;signal transduction;small GTPase mediated signal transduction;transport 9 8 8 44.3 39.2 39.2 23.339 1.4208E-131 9631700 5134100 4497600 4319 IPI:IPI00329441.1;IPI:IPI00785140.3 Ras-related protein Rab-43;Ras-related protein Rab-41;Putative Rab-43-like protein ENSP00000330714 RAB43;RAB41 Q86YS6;A6NDJ8 ENST00000315150;ENST00000393304;ENST00000393305;ENST00000393307;ENST00000393308;ENST00000332781 K07930 2 NaN 1.215 0.74672 NaN 0.83372 0.95194 LIM;VHP actin cytoskeleton;cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle actin binding;binding;cation binding;cytoskeletal protein binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding anatomical structure morphogenesis;cellular component organization;cellular process;cytoskeleton organization;multicellular organismal process;organ morphogenesis;organelle organization;sensory perception;system process;visual perception 4 4 4 6.3 6.3 6.3 87.687 3.0997E-13 31672000 16550000 15121000 4321 IPI:IPI00329495.4;IPI:IPI00456617.5;IPI:IPI00551038.3;IPI:IPI00744789.2 Actin-binding LIM protein 1;Actin-binding LIM protein family member 1;Actin-binding double zinc finger protein;LIMAB1;Limatin ABLIM1;ABLIM;KIAA0059;LIMAB1 O14639-1;O14639;O14639-2;O14639-3;O14639-4 ENST00000336585;ENST00000369262;ENST00000392955 4 1.5324 2.5474 1.5871 1.8376 1.6854 2.0134 WD40 cytoplasmic part;cytoskeletal part;cytosol;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleoplasm;organelle;organelle part;spindle binding;protein binding;protein C-terminus binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;mitosis;nuclear division;organelle organization;proteasomal protein catabolic process;proteolysis;ubiquitin-dependent protein catabolic process Cell cycle;Cell cycle - yeast;Ubiquitin mediated proteolysis 6 6 6 16.2 16.2 16.2 54.722 1.2108E-154 124080000 58584000 65498000 4322 IPI:IPI00329526.3 Cell division cycle protein 20 homolog;p55CDC CDC20 Q12834 ENST00000310955;ENST00000372462 K03363 1 0.46104 0.78287 0.41948 0.61244 0.5103 0.55278 LisH cell part;cytoplasm;intracellular part binding catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 9 9 9 7.1 7.1 7.1 169.01 8.5251E-50 38125000 21648000 16477000 4323 IPI:IPI00329528.12;IPI:IPI00794498.2;IPI:IPI00181396.5;IPI:REV_IPI00872947.2;IPI:REV_IPI00165931.7;IPI:REV_IPI00747751.2;IPI:REV_IPI00748846.2;IPI:REV_IPI00446588.1 Protein VPRBP;HIV-1 Vpr-binding protein;Vpr-interacting protein;DDB1- and CUL4-associated factor 1 VPRBP;DCAF1;KIAA0800;RIP Q9Y4B6-1;Q9Y4B6;Q9Y4B6-2;Q9Y4B6-3 ENST00000273612;ENST00000335891;ENST00000398783 K11789 8 NaN 1.5088 0.70202 NaN 0.93803 0.92741 FYVE cell fraction;cytosol;early endosome membrane;endosomal part;endosome membrane;extrinsic to membrane;extrinsic to plasma membrane;insoluble fraction;intracellular part;membrane;membrane fraction;membrane part;organelle membrane;organelle part binding;calmodulin binding;GTP-dependent protein binding;identical protein binding;ion binding;lipid binding;phosphatidylinositol binding;phosphoinositide binding;phospholipid binding;protein binding;protein homodimerization activity;zinc ion binding cellular component organization;cellular process;endosome transport;membrane fusion;membrane organization;organelle organization;synaptic vesicle to endosome fusion;transport;vesicle fusion;vesicle organization;vesicle-mediated transport 6 6 6 5.4 5.4 5.4 162.46 1.5803E-12 954020000 525300000 428720000 4324 IPI:IPI00329536.2 Early endosome antigen 1;Endosome-associated protein p162;Zinc finger FYVE domain-containing protein 2 EEA1;ZFYVE2 Q15075 ENST00000322349 1 0.75005 1.5098 0.92074 1.0018 0.94549 1.1577 zf-CCCH binding;cation binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding 7 7 7 5 5 5 196.63 1.0373E-59 37353000 19052000 18301000 4325 IPI:IPI00329547.3;IPI:IPI00016472.4 Zinc finger CCCH domain-containing protein 13 ZC3H13;KIAA0853 Q5T200-1;Q5T200;Q5T200-2 ENST00000242848;ENST00000378921 2 0.7401 1.642 0.7733 1.0312 1.0139 1.0783 UQ_con cell part;cytoplasm;intracellular part acid-amino acid ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;ubiquitin-protein ligase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein metabolic process;protein modification process;proteolysis;regulation of metabolic process Parkinson's disease;Ubiquitin mediated proteolysis 4 4 4 39.2 39.2 39.2 17.769 9.9687E-30 113350000 61389000 51960000 4327 IPI:IPI00329563.10;IPI:IPI00386520.3 Ubiquitin/ISG15-conjugating enzyme E2 L6;Ubiquitin-protein ligase L6;Ubiquitin carrier protein L6;UbcH8;Retinoic acid-induced gene B protein UBE2L6;UBCH8 O14933-1;O14933;O14933-2 ENST00000287156 K04553 2 0.68143 1.2567 0.55444 0.90235 0.76931 0.73517 AAA cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity cell differentiation;cellular developmental process;cellular process;developmental process;gamete generation;male gamete generation;multicellular organismal development;multicellular organismal process;reproductive process;spermatogenesis 13 12 12 19.7 18.4 18.4 97.887 2.6116E-149 221190000 123380000 97811000 4328 IPI:IPI00329583.7;IPI:IPI00890715.2;IPI:IPI00890727.1 Spermatogenesis-associated protein 5;Spermatogenesis-associated factor protein;ATPase family protein 2 homolog SPATA5;AFG2;SPAF Q8NB90-1;Q8NB90;Q8NB90-3;Q8NB90-2 ENST00000274008 3 0.71357 1.2968 0.64955 0.8997 0.89736 0.79892 DUF155 3 3 3 6.5 6.5 6.5 51.603 1.0759E-11 9258700 4678900 4579800 4329 IPI:IPI00329591.3;IPI:IPI00643249.1 Required for meiotic nuclear division protein 1 homolog RMND1;C6orf96 Q9NWS8-1;Q9NWS8;Q9NWS8-2 ENST00000367303 2 0.77523 NaN 0.7995 1.0266 NaN 1.0264 ADP_PFK_GK extracellular region binding;catalytic activity;cation binding;ion binding;kinase activity;magnesium ion binding;phosphotransferase activity, alcohol group as acceptor;transferase activity;transferase activity, transferring phosphorus-containing groups alcohol metabolic process;carbohydrate metabolic process;catabolic process;cellular process;generation of precursor metabolites and energy;glucose catabolic process;glucose metabolic process;glycolysis;metabolic process;monosaccharide metabolic process 5 5 5 17.9 17.9 17.9 54.088 4.6442E-90 61735000 33958000 27776000 4330 IPI:IPI00556385.1;IPI:IPI00329593.3;IPI:IPI00550060.2;IPI:IPI00555848.5;IPI:IPI00903303.1 ADP-dependent glucokinase;RbBP-35 ADPGK;PSEC0260 Q9BRR6-1;Q9BRR6;Q9BRR6-2;Q9BRR6-3;Q9BRR6-4 ENST00000311669;ENST00000331065 K08074 5 0.79133 1.8051 0.80406 1.0723 1.1628 1.1056 adh_short cell part;cytoplasm;extracellular region;intracellular part binding;catalytic activity;estradiol 17-beta-dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;steroid dehydrogenase activity androgen catabolic process;androgen metabolic process;biosynthetic process;catabolic process;lipid biosynthetic process;lipid metabolic process;metabolic process;steroid biosynthetic process;steroid catabolic process;steroid metabolic process 8 8 8 33.3 33.3 33.3 32.963 4.3674E-151 53807000 29079000 24728000 4332 IPI:IPI00329598.2 Estradiol 17-beta-dehydrogenase 11;17-beta-hydroxysteroid dehydrogenase 11;17-beta-HSD XI;Dehydrogenase/reductase SDR family member 8;Retinal short-chain dehydrogenase/reductase 2;Cutaneous T-cell lymphoma-associated antigen HD-CL-03;CTCL tumor antigen HD-CL-03 HSD17B11;DHRS8;PAN1B;PSEC0029;UNQ207/PRO233 Q8NBQ5 ENST00000358290 1 0.68538 1.2737 0.70903 0.86749 0.871 0.92593 Saccharop_dh binding;catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on the CH-NH group of donors;oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor;saccharopine dehydrogenase activity metabolic process;oxidation reduction 5 5 5 13.5 13.5 13.5 47.151 9.1539E-23 86755000 49602000 37154000 4333 IPI:IPI00329600.3 Probable saccharopine dehydrogenase SCCPDH;CGI-49 Q8NBX0 ENST00000366510 1 0.98376 1.9046 1.0349 1.3276 1.2462 1.303 DnaJ;TPR_1 binding;heat shock protein binding;protein binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 28 28 28 51 51 51 56.44 0 1660300000 839710000 820630000 4334 IPI:IPI00329629.6 DnaJ homolog subfamily C member 7;Tetratricopeptide repeat protein 2;TPR repeat protein 2 DNAJC7;TPR2;TTC2 Q99615 ENST00000316603 K09527 1 0.79197 1.4721 0.7821 1.0469 0.97947 1.0223 HGTP_anticodon;TGS;tRNA_SAD;tRNA-synt_2b cell part;cytoplasm;intracellular part aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-oxygen bonds;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;threonine-tRNA ligase activity cellular amino acid and derivative metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;threonyl-tRNA aminoacylation;tRNA aminoacylation for protein translation;tRNA metabolic process Aminoacyl-tRNA biosynthesis;Glycine, serine and threonine metabolism 40 40 36 53.4 53.4 48.7 83.434 0 3552100000 1856100000 1696000000 4335 IPI:IPI00329633.5 Threonyl-tRNA synthetase, cytoplasmic;Threonine--tRNA ligase TARS P26639 ENST00000265112 K01868 1 0.56157 1.0755 0.59688 0.78224 0.77234 0.77605 MPPN cell part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;organelle part;pore complex;protein complex cellular process;establishment of protein localization;intracellular protein transport;intracellular transport;mRNA transport;nucleic acid transport;nucleobase, nucleoside, nucleotide and nucleic acid transport;protein transport;RNA transport;transport 7 7 7 33.1 33.1 33.1 34.773 4.5688E-81 121380000 63580000 57796000 4337 IPI:IPI00329650.1 Nucleoporin NUP53;Nuclear pore complex protein Nup53;Nucleoporin Nup35;35 kDa nucleoporin;Mitotic phosphoprotein 44 NUP35;MP44;NUP53 Q8NFH5 ENST00000295119 1 0.70602 1.9006 0.84793 0.98537 1.2004 1.1808 DUF719 binding;nucleotide binding;purine nucleotide binding 9 9 9 27.1 27.1 27.1 56.271 6.026E-29 118860000 46425000 72434000 4338 IPI:IPI00828172.1;IPI:IPI00329662.6 Protein FAM114A2 FAM114A2;C5orf3 Q9NRY5-1;Q9NRY5;Q9NRY5-2 ENST00000351797 2 0.86529 1.7438 0.85654 1.0776 1.1599 1.0694 C2;RasGAP cell part;intracellular enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity cell communication;cellular process;regulation of biological process;regulation of cell communication;regulation of cellular process;regulation of signal transduction;regulation of small GTPase mediated signal transduction;signal transduction 24 24 24 31.2 31.2 31.2 111.9 0 333880000 173260000 160610000 4339 IPI:IPI00329668.7;IPI:IPI00893992.1 RAS protein activator like-3 RASAL3 Q86YV0-1;Q86YV0;Q86YV0-2 ENST00000343625 2 0.52225 0.94549 0.64598 0.72429 0.59772 0.86862 DUF2352 chromosomal part;condensed chromosome kinetochore;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;kinetochore;macromolecular complex;non-membrane-bounded organelle;organelle;organelle part;protein complex binding;protein binding cell cycle checkpoint;cell cycle phase;cell cycle process;cellular component organization;cellular process;mitosis;mitotic cell cycle checkpoint;nuclear division;organelle fission;organelle organization;regulation of mitotic cell cycle 5 5 5 10.5 10.5 10.5 67.213 2.1825E-22 14398000 8212000 6186300 4340 IPI:IPI00329679.3;IPI:IPI00878098.1 Protein zwilch homolog ZWILCH Q9H900-1;Q9H900;Q9H900-2 ENST00000307897 K11579 2 0.8144 1.5115 0.77295 1.0575 0.95948 0.98264 NMT;NMT_C cell part;cytoplasmic part;cytosol;intracellular part acyltransferase activity;catalytic activity;glycylpeptide N-tetradecanoyltransferase activity;N-acyltransferase activity;transferase activity;transferase activity, transferring acyl groups cellular process;metabolic process;N-terminal protein lipidation;N-terminal protein myristoylation;peptidyl-amino acid modification;protein amino acid lipidation;protein lipoylation;protein modification process;protein-cofactor linkage 11 11 11 26.2 26.2 26.2 56.806 4.8497E-144 453290000 238090000 215210000 4342 IPI:IPI00329692.3;IPI:IPI00218830.1;IPI:IPI00030223.3 Glycylpeptide N-tetradecanoyltransferase 1;Peptide N-myristoyltransferase 1;Myristoyl-CoA:protein N-myristoyltransferase 1 NMT1;NMT P30419-1;P30419;P30419-2 ENST00000258960 K00671 3 0.72171 1.8168 0.92533 0.96844 1.1347 1.2398 cell part;cytoplasm;cytoskeletal part;intracellular organelle part;intracellular part;microtubule;organelle part binding 9 9 9 28.7 28.7 28.7 35.808 9.0398E-36 102230000 57832000 44398000 4343 IPI:IPI00329696.1 Regulator of microtubule dynamics protein 1;Protein FAM82B FAM82B;CGI-90 Q96DB5 ENST00000320306 1 NaN 1.2509 NaN NaN 0.89062 NaN IQ;Myosin_head;Myosin_TH1 cell part;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;myosin complex;organelle part;protein complex actin binding;ATP binding;binding;calmodulin binding;catalytic activity;cytoskeletal protein binding;hydrolase activity;motor activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity 5 4 4 4.3 4.3 4.3 116.2 1.484E-94 498520 275210 223320 4344 IPI:IPI00329719.1 Myosin-Id MYO1D;KIAA0727 O94832 ENST00000318217;ENST00000394649 K10356 1 NaN 1.7768 NaN NaN 1.1235 NaN FAA_hydrolase binding;calcium ion binding;catalytic activity;cation binding;hydrolase activity;ion binding;magnesium ion binding;metal ion binding metabolic process 5 1 1 30.6 5.4 5.4 34.596 8.8745E-66 499190 283360 215830 4345 IPI:IPI00329742.2 Fumarylacetoacetate hydrolase domain-containing protein 2A FAHD2A;CGI-105 Q96GK7 ENST00000233379 1 0.73244 1.588 NaN 0.95465 1.0339 NaN DUF2365 2 2 2 11.2 11.2 11.2 23.574 8.0455E-05 9383500 5245900 4137600 4346 IPI:IPI00329748.8 Uncharacterized protein C17orf59 C17orf59 Q96GS4 ENST00000357939;ENST00000389017 1 0.48375 0.94804 0.44869 0.62298 0.63685 0.59509 Pkinase_Tyr;SH2 cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane part;membrane-bounded organelle;nucleus;organelle;protein complex;receptor complex;T cell receptor complex ATP binding;binding;catalytic activity;kinase activity;non-membrane spanning protein tyrosine kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein tyrosine kinase activity;purine nucleoside binding immune system process;positive regulation of immune system process;positive regulation of leukocyte activation;protein amino acid phosphorylation;protein modification process;regulation of immune system process;regulation of leukocyte activation Natural killer cell mediated cytotoxicity;Primary immunodeficiency;T cell receptor signaling pathway 39 39 38 57.4 57.4 56.1 69.872 0 1906800000 1056100000 850770000 4347 IPI:IPI00329789.8;IPI:IPI00885038.1;IPI:IPI00410185.2 Tyrosine-protein kinase ZAP-70;70 kDa zeta-associated protein;Syk-related tyrosine kinase ZAP70;SRK P43403-1;P43403;P43403-3 ENST00000264972;ENST00000389518 K07360 3 0.5473 1.1713 0.61437 0.72496 0.79978 0.80929 DEAD;Helicase_C Cajal body;cell part;intracellular organelle part;intracellular part;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part ATP binding;ATP-dependent helicase activity;binding;catalytic activity;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity;RNA binding cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 34 34 34 32.7 32.7 32.7 117.36 0 1241300000 693850000 547460000 4348 IPI:IPI00329791.12 Probable ATP-dependent RNA helicase DDX46;DEAD box protein 46;PRP5 homolog DDX46;KIAA0801 Q7L014 ENST00000354283 1 0.86267 1.7896 0.93434 1.1282 1.2337 1.2485 Annexin cell part;cytoplasm;intracellular part binding;calcium ion binding;calcium-dependent phospholipid binding;cation binding;enzyme inhibitor activity;enzyme regulator activity;ion binding;lipid binding;metal ion binding;phospholipase inhibitor activity;phospholipid binding;protein binding anti-apoptosis;blood coagulation;cell communication;cellular process;hemostasis;multicellular organismal process;negative regulation of apoptosis;regulation of apoptosis;regulation of cell death;regulation of programmed cell death;signal transduction 18 18 18 52.5 52.5 52.5 35.936 3.4395E-270 1392800000 716440000 676400000 4349 IPI:IPI00329801.12 Annexin A5;Annexin-5;Annexin V;Lipocortin V;Endonexin II;Calphobindin I;Placental anticoagulant protein I;Placental anticoagulant protein 4;Thromboplastin inhibitor;Vascular anticoagulant-alpha;Anchorin CII ANXA5;ANX5;ENX2;PP4 P08758 ENST00000296511 1 0.77403 1.3116 0.72855 1.0662 0.93571 0.91342 Ribonuc_P_40 cell part;intracellular organelle part;intracellular part;macromolecular complex;multimeric ribonuclease P complex;nuclear part;nucleolar part;nucleolar ribonuclease P complex;organelle part;ribonuclease P complex;ribonucleoprotein complex binding;catalytic activity;endonuclease activity;endoribonuclease activity;hydrolase activity;hydrolase activity, acting on ester bonds;nuclease activity;protein binding;ribonuclease activity;ribonuclease P activity;tRNA-specific ribonuclease activity cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;tRNA metabolic process;tRNA processing 6 6 6 20.9 20.9 20.9 41.833 2.741E-30 35196000 19106000 16090000 4351 IPI:IPI00478496.1;IPI:IPI00332091.9 Ribonuclease P protein subunit p40;RNase P subunit 1 RPP40;RNASEP1 O75818-1;O75818;O75818-2 ENST00000319533;ENST00000380051 2 0.58502 1.1804 0.54813 0.75044 0.76617 0.72416 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 2 2 2 2.2 2.2 2.2 105.16 1.7865E-06 3852000 2288400 1563700 4352 IPI:IPI00332097.3;IPI:IPI00411606.2;IPI:IPI00332095.1;IPI:IPI00783452.2 Breast carcinoma-amplified sequence 3;Maab1 protein;GAOB1 BCAS3 Q9H6U6-4;Q9H6U6;Q9H6U6-3;Q9H6U6-1;Q9H6U6-2 ENST00000340746;ENST00000390652;ENST00000405070;ENST00000407086;ENST00000408905 4 1.06 2.2736 1.3272 1.2982 1.5955 1.6071 cell part;cytoplasmic part;cytoskeletal part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;microtubule;nucleus;organelle;organelle part binding;protein binding;transcription cofactor activity;transcription corepressor activity;transcription factor binding;transcription regulator activity;transcription repressor activity cellular process;multicellular organismal development;negative regulation of biosynthetic process;negative regulation of metabolic process;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process 7 7 7 11.8 11.8 11.8 80.642 5.1224E-51 63748000 44194000 19554000 4353 IPI:IPI00332106.2;IPI:IPI00645060.1;IPI:IPI00220556.5 Pre-B-cell leukemia transcription factor-interacting protein 1;Hematopoietic PBX-interacting protein PBXIP1;HPIP Q96AQ6-1;Q96AQ6;Q96AQ6-2;Q96AQ6-3 ENST00000309136;ENST00000351146;ENST00000368463 3 0.77567 1.4709 0.73854 1.0027 0.96361 0.95448 PFK 6-phosphofructokinase complex;cell part;cytoplasmic part;cytosolic part;intracellular part;macromolecular complex;protein complex 6-phosphofructokinase activity;ATP binding;binding;catalytic activity;kinase activity;magnesium ion binding;nucleoside binding;nucleotide binding;phosphofructokinase activity;protein binding;purine nucleoside binding;sugar binding;transferase activity alcohol metabolic process;carbohydrate metabolic process;fructose 6-phosphate metabolic process;fructose metabolic process;generation of precursor metabolites and energy;glucose catabolic process;glucose metabolic process;monosaccharide metabolic process Fructose and mannose metabolism;Galactose metabolism;Glycolysis / Gluconeogenesis;Pentose phosphate pathway 16 12 12 26.5 20.8 20.8 85.018 0 213150000 114660000 98489000 4354 IPI:IPI00332371.9;IPI:IPI00925520.1 6-phosphofructokinase, liver type;Phosphofructokinase 1;Phosphohexokinase;Phosphofructo-1-kinase isozyme B PFKL P17858-1;P17858;P17858-2 ENST00000312352;ENST00000349048;ENST00000397961;ENST00000403390 K00850 2 0.6827 1.3546 0.72414 0.93277 0.89748 0.94195 Mak16 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part 8 8 8 31.3 31.3 31.3 35.368 1.9366E-146 269740000 144850000 124890000 4355 IPI:IPI00332428.5 Protein MAK16 homolog;Protein RBM13;NNP78 MAK16;RBM13 Q9BXY0 ENST00000360128 1 0.65625 1.2077 0.65113 0.84379 0.84758 0.86742 PP2A_B_N;PP2A_B_subs_rcg cell part;intracellular part;macromolecular complex;protein complex;protein phosphatase type 2A complex;protein serine/threonine phosphatase complex binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;phosphatase activity;phosphoprotein phosphatase activity;protein binding;protein phosphatase type 2A regulator activity;protein serine/threonine phosphatase activity cell communication;cellular process;dephosphorylation;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid dephosphorylation;protein metabolic process;protein modification process;signal transduction 14 14 10 37.4 37.4 26 51.691 1.4196E-151 991470000 539240000 452230000 4356 IPI:IPI00332511.5;IPI:IPI00376973.2;IPI:IPI00944548.1;IPI:IPI00944557.1;IPI:IPI00376972.2;IPI:IPI00020850.5;IPI:IPI00032462.3;IPI:IPI00178803.4;IPI:IPI00871687.1 Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform;PP2A, subunit B, B55-alpha isoform;PP2A, subunit B, PR55-alpha isoform;PP2A, subunit B, R2-alpha isoform PPP2R2A P63151 ENST00000315985;ENST00000380737 K04354 9 0.74259 1.4219 0.79291 0.95799 0.94543 1.0177 DUF618;G-patch;Surp cell part;cytoplasmic part;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle;perinuclear region of cytoplasm binding;nucleic acid binding;RNA binding cellular process;developmental process;metabolic process;nervous system development;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing 14 14 14 17.8 17.8 17.8 103.57 9.1669E-123 577850000 305530000 272320000 4358 IPI:IPI00333010.8 Calcium homeostasis endoplasmic reticulum protein;SR-related CTD-associated factor 6;ERPROT 213-21 CHERP;DAN26;SCAF6 Q8IWX8 ENST00000198939 1 0.48934 1.027 0.69775 0.65095 0.6689 0.88893 cell part;chromosomal part;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;microtubule;organelle part;outer kinetochore of condensed chromosome;protein complex;spindle microtubule binding;protein binding cell cycle phase;cell cycle process;cellular component organization;cellular process;chromosome segregation;mitosis;nuclear division;organelle organization;regulation of microtubule polymerization or depolymerization 6 6 6 18.2 18.2 18.2 46.359 1.2152E-123 32194000 15367000 16827000 4359 IPI:IPI00333014.3;IPI:IPI00472738.1;IPI:IPI00789249.1 Spindle and kinetochore-associated protein 3 SKA3;C13orf3;RAMA1 Q8IX90-1;Q8IX90;Q8IX90-2;Q8IX90-3 ENST00000314759 3 0.72132 NaN 0.73029 0.91645 NaN 1.1687 CH;PH;Spectrin cytoplasmic part;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;M band;membrane;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;plasma membrane;spectrin actin binding;binding;calmodulin binding;cytoskeletal protein binding;protein binding;structural constituent of cytoskeleton;structural molecule activity negative regulation of macromolecule metabolic process;negative regulation of metabolic process;negative regulation of organelle organization;regulation of actin polymerization or depolymerization;regulation of metabolic process 111 2 2 60.8 1.8 1.8 251.39 0 13721000 6190700 7530200 4360 IPI:IPI00333015.7 Spectrin beta chain, brain 1;Spectrin, non-erythroid beta chain 1;Beta-II spectrin;Fodrin beta chain SPTBN1;SPTB2 Q01082-3;Q01082 ENST00000333896;ENST00000356805;ENST00000389980 K06115 1 0.6413 1.2062 0.64568 0.82353 0.82577 0.84169 DnaJ binding;heat shock protein binding;protein binding 12 12 12 26.1 26.1 26.1 63.277 6.0842E-114 193300000 105560000 87733000 4361 IPI:IPI00465290.3;IPI:IPI00333016.6;IPI:IPI00607744.3 DnaJ homolog subfamily C member 11 DNAJC11 Q9NVH1-1;Q9NVH1;Q9NVH1-3;Q9NVH1-2 ENST00000294401;ENST00000377577 K09531 3 0.51975 NaN NaN 0.69935 NaN NaN HECT;RCC1 cell part;cytoplasmic part;cytosol;intracellular part acid-amino acid ligase activity;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;protein modification process;proteolysis Ubiquitin mediated proteolysis 4 4 4 4.4 4.4 4.4 118.56 1.4348E-06 6321500 3623100 2698300 4362 IPI:IPI00333067.3;IPI:IPI00604497.2;IPI:IPI00827948.1;IPI:IPI00827523.1 Probable E3 ubiquitin-protein ligase HERC4;HECT domain and RCC1-like domain-containing protein 4 HERC4;KIAA1593 Q5GLZ8-1;Q5GLZ8;Q5GLZ8-2;Q5GLZ8-3;Q5GLZ8-6 ENST00000373700;ENST00000395185;ENST00000395187;ENST00000395198 K10615 4 1.6924 4.4997 1.7636 2.2913 2.8157 2.2463 WD40 actin cytoskeleton;cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle actin binding;binding;cytoskeletal protein binding;protein binding actin cytoskeleton organization;actin filament-based process;cellular component organization;cellular process;cytoskeleton organization;organelle organization;regulation of actin polymerization or depolymerization;regulation of metabolic process Regulation of actin cytoskeleton 8 7 7 30.3 24.1 24.1 41.569 6.0383E-102 65602000 28951000 36651000 4363 IPI:IPI00333068.4 Actin-related protein 2/3 complex subunit 1A;SOP2-like protein ARPC1A;SOP2L Q92747 ENST00000262942 K05757 1 0.62748 1.3647 0.64943 0.81623 0.89421 0.81612 C1_1;DAGK_acc;DAGK_cat;efhand ATP binding;binding;calcium ion binding;catalytic activity;diacylglycerol kinase activity;kinase activity;lipid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;transferase activity;zinc ion binding activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway;cell communication;cell surface receptor linked signal transduction;G-protein coupled receptor protein signaling pathway;signal transduction Glycerolipid metabolism;Glycerophospholipid metabolism;Phosphatidylinositol signaling system 15 15 15 26.3 26.3 26.3 82.629 3.5361E-263 234280000 127370000 106910000 4364 IPI:IPI00333143.4;IPI:IPI00644617.7 Diacylglycerol kinase alpha;Diglyceride kinase alpha;80 kDa diacylglycerol kinase DGKA;DAGK;DAGK1 P23743-1;P23743 ENST00000331886;ENST00000394145;ENST00000394147;ENST00000402956 K00901 2 0.9273 2.0769 NaN 1.262 1.2497 NaN GRIP cell part;cytoplasmic part;Golgi apparatus part;Golgi membrane;intracellular organelle part;intracellular part;membrane;organelle membrane;organelle part binding;identical protein binding;protein binding 7 6 6 4.7 4.1 4.1 195.91 5.8375E-17 7724900 3637900 4087100 4365 IPI:IPI00333197.4;IPI:IPI00005631.2 GRIP and coiled-coil domain-containing protein 2;Golgi coiled-coil protein GCC185;Ran-binding protein 2-like 4;CTCL tumor antigen se1-1;CLL-associated antigen KW-11;Renal carcinoma antigen NY-REN-53 GCC2;KIAA0336;RANBP2L4 Q8IWJ2-2;Q8IWJ2;Q8IWJ2-1 ENST00000309863;ENST00000393321;ENST00000409325 2 0.94057 1.7223 0.99885 1.2286 1.1079 1.2469 TFIIS;TFIIS_C;TFIIS_M cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;DNA binding;nucleic acid binding;RNA polymerase II transcription factor activity;transcription elongation regulator activity;translation elongation factor activity;translation factor activity, nucleic acid binding;zinc ion binding biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA elongation;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent Basal transcription factors 16 16 16 54.2 54.2 54.2 33.969 2.6772E-179 841960000 372230000 469740000 4366 IPI:IPI00333215.1;IPI:IPI00218106.3;IPI:IPI00018403.3 Transcription elongation factor A protein 1;Transcription elongation factor S-II protein 1;Transcription elongation factor TFIIS.o TCEA1;GTF2S;TFIIS P23193-1;P23193;P23193-2 ENST00000360389;ENST00000399633 K03145 3 0.94769 1.7663 0.92386 1.2622 1.1359 1.2178 Pkinase cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;kinase activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cell communication;intracellular signaling cascade;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein kinase cascade;protein modification process;signal transduction;spliceosome assembly 11 8 8 17.6 13.4 13.4 77.542 1.0922E-35 123960000 64896000 59060000 4367 IPI:IPI00333420.5 Serine/threonine-protein kinase SRPK2;Serine/arginine-rich protein-specific kinase 2;SFRS protein kinase 2 SRPK2 P78362 ENST00000336613;ENST00000357311 K08831 1 0.96618 1.4125 0.8449 1.2111 0.9361 1.1432 Pkinase cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity chromatin organization;intracellular protein transport;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;regulation of chromatin assembly or disassembly;response to stress;transport 9 6 6 16.4 11.9 11.9 89.022 2.1179E-122 7288800 4234900 3054000 4368 IPI:IPI00333559.1;IPI:IPI00339361.5;IPI:IPI00746072.3 Serine/threonine-protein kinase tousled-like 1;Tousled-like kinase 1;PKU-beta TLK1;KIAA0137 Q9UKI8-2;Q9UKI8;Q9UKI8-1;Q9UKI8-3 ENST00000359766;ENST00000360843 3 0.65889 1.263 0.60778 0.876 0.85015 0.81344 Aldedh cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part 3-chloroallyl aldehyde dehydrogenase activity;aldehyde dehydrogenase (NAD) activity;aldehyde dehydrogenase [NAD(P)+] activity;catalytic activity;oxidoreductase activity cellular aldehyde metabolic process;cellular process;central nervous system development;developmental process;epidermis development;lipid metabolic process;metabolic process;peripheral nervous system development;tissue development 1,2-Dichloroethane degradation;3-Chloroacrylic acid degradation;Arginine and proline metabolism;Ascorbate and aldarate metabolism;beta-Alanine metabolism;Butanoate metabolism;Fatty acid metabolism;Glycerolipid metabolism;Glycolysis / Gluconeogenesis;Histidine metabolism;Limonene and pinene degradation;Lysine degradation;Propanoate metabolism;Pyruvate metabolism;Tryptophan metabolism;Valine, leucine and isoleucine degradation 9 9 8 21.9 21.9 19.5 57.669 4.015E-114 58246000 32058000 26188000 4369 IPI:IPI00394758.1;IPI:IPI00333619.4;IPI:IPI00018031.1;IPI:IPI00296183.7;IPI:IPI00166751.3 Fatty aldehyde dehydrogenase;Aldehyde dehydrogenase family 3 member A2;Aldehyde dehydrogenase 10;Microsomal aldehyde dehydrogenase ALDH3A2;ALDH10;FALDH P51648-2;P51648;P51648-1 ENST00000176643;ENST00000339618;ENST00000395575;ENST00000404114 K00128 5 0.48456 1.2164 0.54849 0.64256 0.78678 0.70141 HEAT binding 8 8 8 5.6 5.6 5.6 224.3 1.2372E-62 40170000 22872000 17298000 4370 IPI:IPI00479069.1;IPI:IPI00333696.6;IPI:IPI00877102.1 HEAT repeat-containing protein 5B HEATR5B;KIAA1414 Q9P2D3-1;Q9P2D3;Q9P2D3-3 ENST00000233099 3 0.76321 1.8335 0.95434 1.0503 1.1408 1.404 HCNGP cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding apoptosis;biosynthetic process;cell death;induction of apoptosis;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 6 6 6 19.8 19.8 19.8 33.87 3.1224E-53 48925000 23600000 25325000 4371 IPI:IPI00549296.4;IPI:IPI00333699.5 SAP30-binding protein;Transcriptional regulator protein HCNGP SAP30BP;HCNGP;HTRG;HTRP Q9UHR5-1;Q9UHR5;Q9UHR5-2 ENST00000293208;ENST00000355423 2 0.6431 1.5739 0.75011 1.0585 1.0199 0.94673 Glutaredoxin cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle catalytic activity;disulfide oxidoreductase activity;electron carrier activity;oxidoreductase activity;oxidoreductase activity, acting on sulfur group of donors;protein disulfide oxidoreductase activity biological regulation;cell redox homeostasis;cellular homeostasis;cellular process;homeostatic process;regulation of biological process;regulation of biological quality;regulation of cellular process 4 4 4 23.6 23.6 23.6 16.628 2.6017E-93 111080000 61039000 50039000 4372 IPI:IPI00333763.7 Glutaredoxin-related protein 5 GLRX5;C14orf87 Q86SX6 ENST00000331334 K07390 1 0.79425 2.0007 0.81402 1.0893 1.2055 1.086 Ded_cyto;PH binding;enzyme binding;enzyme regulator activity;GTP binding;GTPase regulator activity;guanyl nucleotide binding;guanyl-nucleotide exchange factor activity;nucleotide binding;protein binding;purine nucleotide binding;ribonucleotide binding 5 5 5 2.4 2.4 2.4 249.53 2.5776E-17 39254000 21354000 17900000 4373 IPI:IPI00333770.6;IPI:IPI00375113.4 Dedicator of cytokinesis protein 10;Zizimin-3 DOCK10;KIAA0694;ZIZ3 Q96BY6-1;Q96BY6 ENST00000258390;ENST00000409592 2 0.74494 1.5805 0.67768 1.0756 0.92407 0.99004 cell part;cytoplasmic part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;organelle establishment of localization;establishment of protein localization;protein transport;transport 2 2 2 5.7 5.7 5.7 50.033 2.3999E-40 10429000 5082500 5346700 4374 IPI:IPI00333908.1;IPI:IPI00554633.1;IPI:IPI00470831.2 Coiled-coil domain-containing protein 91;GGA-binding partner;p56 accessory protein CCDC91;GGABP;HSD8 Q7Z6B0-1;Q7Z6B0;Q7Z6B0-2;Q7Z6B0-3 ENST00000306172;ENST00000381256;ENST00000381259 3 0.85994 1.7021 0.83699 1.0886 1.1617 1.0543 Sec39 26 26 26 12.3 12.3 12.3 268.57 5.908E-200 245080000 134330000 110750000 4375 IPI:IPI00333913.9;IPI:IPI00847551.2;IPI:REV_IPI00927614.1;IPI:REV_IPI00013272.1;IPI:REV_IPI00220522.1;IPI:REV_IPI00441959.1;IPI:REV_IPI00441960.3;IPI:REV_IPI00441955.1;IPI:REV_IPI00441952.3;IPI:REV_IPI00329695.4;IPI:REV_IPI00921003.1;IPI:REV_IPI00171791.6;IPI:REV_IPI00334728.1;IPI:REV_IPI00297415.2;IPI:REV_IPI00006024.4 Neuroblastoma-amplified sequence;Neuroblastoma-amplified gene protein NBAS;NAG A2RRP1-1;A2RRP1;A2RRP1-2 ENST00000281513 15 0.70945 1.4011 0.703 0.93484 0.94368 0.93793 Cna_B cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part binding;carbohydrate binding;protein binding 16 16 1 16.7 16.7 1.7 139.44 6.5689E-164 355160000 183340000 171810000 4377 IPI:IPI00465432.3;IPI:IPI00872411.1;IPI:IPI00333985.2 Nodal modulator 2;pM5 protein 2;Nodal modulator 3;pM5 protein 3 NOMO2;NOMO3 Q5JPE7-1;Q5JPE7;P69849;Q5JPE7-2 ENST00000330537;ENST00000381474;ENST00000263012;ENST00000399336 3 0.77782 1.5973 0.84879 1.0179 1.038 1.1234 Prefoldin cell part;cytoplasmic part;cytosolic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;prefoldin complex;protein complex binding;protein binding;unfolded protein binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 10 10 10 39.9 39.9 39.9 26.535 4.5275E-92 651240000 345230000 306000000 4378 IPI:IPI00334159.6 Prefoldin subunit 3;Von Hippel-Lindau-binding protein 1;HIBBJ46 VBP1;PFDN3 P61758 ENST00000286428 1 0.79826 1.8111 0.79457 1.0672 1.1934 1.0652 Band_7 cell part;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle binding;protein binding;receptor binding 17 17 17 69.7 69.7 69.7 38.534 0 935670000 504680000 430990000 4379 IPI:IPI00334190.4 Stomatin-like protein 2;EPB72-like 2 STOML2;SLP2;HSPC108 Q9UJZ1 ENST00000356493 1 0.89912 1.1919 0.99418 1.2306 0.79487 1.2074 extracellular region binding;cytokine activity;protein binding;receptor binding 3 3 3 16.7 16.7 16.7 24.68 1.2658E-40 19791000 10025000 9765800 4381 IPI:IPI00334282.2 Protein FAM3C FAM3C;GS3786 Q92520 ENST00000359943 1 0.59785 1.5386 0.66114 0.86496 0.81748 0.89102 CBFNT;RRM_1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;mRNA binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding anatomical structure morphogenesis;cell morphogenesis;cell morphogenesis involved in differentiation;epithelial to mesenchymal transition;regulation of biosynthetic process;regulation of transcription, DNA-dependent 14 14 4 27.4 27.4 5.1 35.967 0 1754900000 957990000 796940000 4382 IPI:IPI00334587.1;IPI:IPI00334713.1 Heterogeneous nuclear ribonucleoprotein A/B;APOBEC1-binding protein 1 HNRNPAB;ABBP1;HNRPAB Q99729-2;Q99729;Q99729-3 ENST00000355836;ENST00000358344;ENST00000359535 2 0.97452 1.662 1.0627 1.2893 1.1198 1.3339 Cyclin_N cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 5 5 5 18.5 18.5 18.5 39.336 3.1556E-104 88244000 43322000 44923000 4384 IPI:IPI00465457.4;IPI:IPI00334743.4;IPI:IPI00413625.1;IPI:IPI00871180.1;IPI:IPI00413695.2;IPI:IPI00185371.5;IPI:IPI00914033.2 Cyclin-Y;Cyclin fold protein 1;Cyclin box protein 1 CCNY;C10orf9;CBCP1;CFP1 Q8ND76-1;Q8ND76;Q8ND76-2;Q8ND76-3 ENST00000265375;ENST00000339497;ENST00000374704 7 0.81082 1.5246 0.81611 1.0966 0.98889 1.0845 IP_trans cell part;cytoplasmic part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;lipid binding establishment of localization;lipid metabolic process;metabolic process;primary metabolic process;transport 18 18 17 66.3 66.3 63 31.7 4.3811E-162 711730000 389750000 321980000 4386 IPI:IPI00395939.4;IPI:IPI00334907.3 Phosphatidylinositol transfer protein beta isoform PITPNB P48739-2;P48739;P48739-1 ENST00000320996;ENST00000335272 2 0.82385 1.351 0.95084 0.99608 0.95813 1.1994 TRM cell part;intracellular binding;catalytic activity;methyltransferase activity;N-methyltransferase activity;nucleic acid binding;RNA binding;RNA methyltransferase activity;tRNA (guanine-N2-)-methyltransferase activity;tRNA methyltransferase activity;zinc ion binding behavior;cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;tRNA metabolic process;tRNA processing 11 11 11 19.4 19.4 19.4 81.746 3.3468E-212 110210000 57004000 53205000 4387 IPI:IPI00334914.2;IPI:IPI00844404.2 TRM1-like protein TRM1L;C1orf25;MSTP070 Q7Z2T5-1;Q7Z2T5 ENST00000367504;ENST00000367506 2 0.88832 1.8055 0.90982 1.1523 1.0857 1.28 binding;protein binding 5 5 5 34.3 34.3 34.3 19.332 1.2143E-21 203330000 100190000 103130000 4388 IPI:IPI00335001.2;IPI:IPI00395462.4 Huntingtin-interacting protein K;Huntingtin yeast partner K HYPK;HSPC136 Q9NX55-1;Q9NX55;Q9NX55-2 ENST00000337861;ENST00000409617 2 0.53336 1.1868 NaN 0.72788 0.82681 NaN SPRY;zf-C3HC4 cell part;cytoplasm;intracellular part binding;catalytic activity;cation binding;ion binding;ligase activity;metal ion binding;protein binding;transition metal ion binding;zinc ion binding catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 3 3 3 2.1 2.1 2.1 148.96 3.1418E-05 25941000 15746000 10195000 4389 IPI:IPI00783374.2;IPI:IPI00335085.5 E3 ubiquitin-protein ligase RNF123;RING finger protein 123;Kip1 ubiquitination-promoting complex protein 1 RNF123;KPC1;FP1477 Q5XPI4-2;Q5XPI4;Q5XPI4-1 ENST00000327697;ENST00000389066 K12169 2 0.64829 1.3851 0.71526 0.87305 0.93855 0.89113 efhand cell part;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;myosin complex;organelle part;protein complex;unconventional myosin complex binding;calcium ion binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;motor activity;pyrophosphatase activity;structural constituent of muscle;structural molecule activity actin filament-based movement;actin filament-based process;cellular process;cytoskeleton-dependent intracellular transport;muscle filament sliding;skeletal muscle tissue development;striated muscle tissue development;tissue development;transport 10 10 8 61.6 61.6 45.7 16.93 1.3633E-204 2944700000 1559000000 1385700000 4391 IPI:IPI00335168.9;IPI:IPI00789605.1 Myosin light polypeptide 6;Smooth muscle and nonmuscle myosin light chain alkali 6;Myosin light chain alkali 3;LC17 MYL6 P60660-1;P60660;P60660-2 ENST00000293422;ENST00000348108;ENST00000405661 K05738 2 0.67702 1.5715 0.86707 0.93862 1.0716 1.0668 MARVEL clathrin-coated vesicle;coated vesicle;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle membrane;integral to membrane;integral to plasma membrane;intrinsic to membrane;membrane;organelle membrane;synaptic vesicle;vesicle membrane transporter activity cell communication;cell-cell signaling;cellular process;establishment of localization;synaptic transmission;transport 4 4 4 17.4 17.4 17.4 28.565 2.6877E-25 237010000 126220000 110780000 4393 IPI:IPI00009507.1;IPI:IPI00335277.1 Synaptophysin-like protein 1;Pantophysin SYPL1;SYPL Q16563-1;Q16563;Q16563-2 ENST00000011473 2 0.90454 1.5338 0.89025 1.1311 1.0846 1.1098 Ribul_P_3_epim cell part;cytoplasmic part;cytosol;intracellular part binding;catalytic activity;isomerase activity;protein binding;racemase and epimerase activity;racemase and epimerase activity, acting on carbohydrates and derivatives;ribulose-phosphate 3-epimerase activity carbohydrate metabolic process;metabolic process;primary metabolic process Carbon fixation in photosynthetic organisms;Pentose and glucuronate interconversions;Pentose phosphate pathway 2 2 2 11.4 11.4 11.4 24.927 4.7161E-65 161410000 83774000 77636000 4394 IPI:IPI00335280.3;IPI:IPI00373788.1 Ribulose-phosphate 3-epimerase;Ribulose-5-phosphate-3-epimerase RPE;HUSSY-17 Q96AT9-1;Q96AT9;Q96AT9-2 ENST00000354506;ENST00000359429 K01783 2 0.70603 1.3199 0.71448 0.91858 0.89607 0.90279 DcpS cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;hydrolase activity;protein binding deadenylation-dependent decapping of nuclear-transcribed mRNA;nuclear-transcribed mRNA catabolic process;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 13 13 13 38.6 38.6 38.6 38.608 0 575820000 308740000 267070000 4395 IPI:IPI00335385.4 Scavenger mRNA-decapping enzyme DcpS;DCS-1;Hint-related 7meGMP-directed hydrolase;Histidine triad protein member 5 DCPS;DCS1;HINT5;HSPC015 Q96C86 ENST00000263579 K01567 1 NaN NaN 0.88675 NaN NaN 1.1695 AAA;Vps4_C ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;magnesium ion binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;nucleotide metabolic process;purine nucleotide metabolic process 4 3 2 5.9 4.2 3.1 74.076 7.5639E-08 42616000 36609000 6007500 4396 IPI:IPI00335421.4;IPI:IPI00855706.1 Fidgetin-like protein 1 FIGNL1 Q6PIW4-1;Q6PIW4;Q6PIW4-2 ENST00000356889;ENST00000395556 2 0.48034 0.90168 0.5038 0.65042 0.60937 0.67338 TIMELESS;TIMELESS_C cell part;chromatin;chromosomal part;intracellular organelle part;intracellular part;nuclear chromatin;nuclear chromosome part;nuclear part;organelle part binding;protein binding morphogenesis of an epithelium;nitrogen compound metabolic process;nuclear division;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;response to stress;transcription 9 9 9 9.4 9.4 9.4 138.63 2.0438E-164 67762000 38404000 29358000 4397 IPI:IPI00335541.4;IPI:IPI00554678.1 Protein timeless homolog TIMELESS;TIM;TIM1;TIMELESS1 Q9UNS1-1;Q9UNS1;Q9UNS1-2 ENST00000229201 K03155 2 0.7045 1.4614 0.61783 0.95664 0.94775 0.7999 SpoU_methylase;SpoU_sub_bind binding;catalytic activity;methyltransferase activity;nucleic acid binding;protein binding;RNA binding;RNA methyltransferase activity;transferase activity;transferase activity, transferring one-carbon groups cellular biopolymer metabolic process;cellular process;macromolecule metabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing 5 5 5 11.2 11.2 11.2 47.019 1.4447E-10 85810000 46773000 39037000 4398 IPI:IPI00335589.5 RNA methyltransferase-like protein 1 RNMTL1;HC90 Q9HC36 ENST00000304478 1 0.52762 0.7473 0.43094 0.68905 0.51944 0.55541 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 4 4 4 6.2 6.2 6.2 106.11 2.942E-11 8459400 5193700 3265700 4399 IPI:IPI00335946.4;IPI:IPI00894229.1 Constitutive coactivator of peroxisome proliferator-activated receptor gamma;PPARG constitutive coactivator 1;Protein FAM120B FAM120B;CCPG;KIAA1838 Q96EK7-1;Q96EK7;Q96EK7-2 ENST00000366751 2 0.64187 1.4581 NaN 0.87676 0.93064 NaN NTP_transf_2;PAP_assoc;zf-CCHC cell part;intracellular binding;catalytic activity;cation binding;ion binding;metal ion binding;nucleic acid binding;nucleotidyltransferase activity;transferase activity;transferase activity, transferring phosphorus-containing groups;transition metal ion binding;zinc ion binding 2 2 2 1.5 1.5 1.5 171.23 4.2605E-46 7576800 4421300 3155500 4400 IPI:IPI00604491.1;IPI:IPI00336000.6;IPI:IPI00552923.1;IPI:IPI00374531.5;IPI:IPI00604680.1;IPI:IPI00604635.1 Zinc finger CCHC domain-containing protein 6 ZCCHC6;KIAA1711 Q5VYS8-1;Q5VYS8;Q5VYS8-6;Q5VYS8-4;Q5VYS8-2;Q5VYS8-3;Q5VYS8-5 ENST00000375961;ENST00000375963 6 0.67839 1.4831 0.67723 0.96921 0.92373 0.97796 tRNA-synt_1e cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;cysteine-tRNA ligase activity;ligase activity;ligase activity, forming carbon-oxygen bonds;nucleoside binding;nucleotide binding;purine nucleoside binding;zinc ion binding cellular amino acid and derivative metabolic process;cysteinyl-tRNA aminoacylation;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;tRNA aminoacylation for protein translation;tRNA metabolic process Aminoacyl-tRNA biosynthesis;Cysteine metabolism 12 12 12 23.6 23.6 23.6 62.223 1.4225E-76 2044300000 1133000000 911350000 4401 IPI:IPI00336016.3 Probable cysteinyl-tRNA synthetase, mitochondrial;Cysteine--tRNA ligase CARS2;OK/SW-cl.10 Q9HA77 ENST00000257347 K01883 1 0.3772 0.8704 0.43232 0.47172 0.6164 0.53493 Methyltransf_11 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;methyltransferase activity;nucleic acid binding;nucleotide binding;RNA binding;transferase activity;transferase activity, transferring one-carbon groups metabolic process 9 9 9 17.8 17.8 17.8 68.725 1.3362E-20 55399000 34150000 21249000 4402 IPI:IPI00337307.3;IPI:IPI00472176.1 tRNA (uracil-5-)-methyltransferase homolog A;HpaII tiny fragments locus 9c protein TRMT2A;HTF9C Q8IZ69-1;Q8IZ69;Q8IZ69-2 ENST00000402382;ENST00000403707;ENST00000404751 2 0.79405 1.998 NaN 1.189 1.1743 NaN DWNN;U-box;zf-CCHC intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;protein complex;ubiquitin ligase complex acid-amino acid ligase activity;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleic acid binding;protein binding;small conjugating protein ligase activity;ubiquitin-protein ligase activity;zinc ion binding cellular biopolymer metabolic process;cellular process;macromolecule metabolic process;metabolic process;protein metabolic process;protein modification by small protein conjugation;protein modification process;protein ubiquitination 4 4 4 3.7 3.7 3.7 201.56 4.5034E-26 9426100 5465500 3960600 4403 IPI:IPI00337315.1;IPI:IPI00376283.1;IPI:IPI00744671.1 Retinoblastoma-binding protein 6;p53-associated cellular protein of testis;Proliferation potential-related protein;Protein P2P-R;Retinoblastoma-binding Q protein 1 RBBP6;P2PR;PACT;RBQ1;My038 Q7Z6E9-1;Q7Z6E9;Q7Z6E9-2;Q7Z6E9-4 ENST00000319715;ENST00000348022;ENST00000381039 3 1.7759 4.5105 1.8691 2.4159 2.6215 2.5192 cell part;cell surface;cytoplasm;intracellular part binding;carbohydrate binding;glycosaminoglycan binding;hyaluronic acid binding;pattern binding;polysaccharide binding ECM-receptor interaction 9 9 9 13.8 13.8 13.8 84.228 9.0282E-29 23889000 11990000 11898000 4404 IPI:IPI00337772.4;IPI:IPI00337325.3;IPI:IPI00844515.2 Hyaluronan mediated motility receptor;Intracellular hyaluronic acid-binding protein;Receptor for hyaluronan-mediated motility HMMR;IHABP;RHAMM O75330-3;O75330;O75330-1;O75330-2 ENST00000353866;ENST00000358715;ENST00000393915 K06267 3 1.0354 1.939 NaN 1.3254 1.3899 NaN IQ;Myosin_head;Myosin_N;Myosin_tail_1 cell part;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;myosin complex;organelle part;protein complex actin binding;ATP binding;binding;calmodulin binding;catalytic activity;cytoskeletal protein binding;hydrolase activity;motor activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity multicellular organismal process;regulation of anatomical structure morphogenesis;regulation of biological process;regulation of cell morphogenesis;regulation of cell shape;sensory perception;sensory perception of sound;system process Tight junction 9 2 2 4.6 0.7 0.7 231.21 1.36E-119 19704000 10530000 9173600 4405 IPI:IPI00941217.1;IPI:IPI00337335.7;IPI:IPI00607778.1;IPI:IPI00029818.5 Myosin-14;Myosin heavy chain 14;Myosin heavy chain, non-muscle IIc;Non-muscle myosin heavy chain IIc MYH14;KIAA2034;FP17425 Q7Z406-2;Q7Z406;Q7Z406-1;Q7Z406-4;Q7Z406-5 ENST00000301415;ENST00000376965;ENST00000376970 K10352 4 0.73141 1.6667 0.84377 0.98792 1.0867 1.0977 FF;WW cell part;intracellular organelle part;intracellular part;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part binding;protein binding cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 11 11 11 12.1 12.1 12.1 112.4 6.8854E-93 364720000 196860000 167860000 4407 IPI:IPI00337386.3;IPI:IPI00337385.3;IPI:IPI00337387.3;IPI:IPI00397509.3 Pre-mRNA-processing factor 40 homolog A;Formin-binding protein 3;Formin-binding protein 11;Huntingtin-interacting protein A;Huntingtin yeast partner A;Fas ligand-associated factor 1;NY-REN-6 antigen PRPF40A;FBP11;FLAF1;FNBP3;HYPA;HSPC225 O75400-2;O75400;O75400-1;O75400-3;O75400-4 ENST00000354363;ENST00000356402;ENST00000359961;ENST00000410080 4 0.71042 1.3485 0.70639 0.93539 0.9261 0.8966 Nucleoporin2 cell part;intracellular organelle part;intracellular part;macromolecular complex;membrane;membrane part;nuclear membrane;nuclear part;nuclear pore;nucleoplasm;organelle membrane;organelle part;pore complex;protein complex binding;protein binding;structural constituent of nuclear pore;structural molecule activity;transporter activity DNA metabolic process;DNA replication;intracellular protein transport;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein complex assembly;protein import into nucleus, docking;transport 31 31 31 21.8 21.8 21.8 195.82 0 391090000 207420000 183670000 4408 IPI:IPI00337397.1;IPI:IPI00953181.1;IPI:IPI00216688.4;IPI:IPI00006038.4;IPI:IPI00337395.1;IPI:IPI00936708.1 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nucleoporin Nup98;98 kDa nucleoporin;Nuclear pore complex protein Nup96;Nucleoporin Nup96;96 kDa nucleoporin NUP98;ADAR2 P52948-5;P52948;P52948-6;P52948-2;P52948-1 ENST00000324932;ENST00000359171;ENST00000397018 6 0.7473 1.7443 0.77986 0.95568 1.2101 1.026 efhand;Mito_carr cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part binding;calcium ion binding;cation binding;ion binding;metal ion binding establishment of localization;transport 9 9 9 21.4 21.4 21.4 53.354 4.4314E-98 175420000 95607000 79816000 4409 IPI:IPI00337494.7;IPI:IPI00412742.1 Calcium-binding mitochondrial carrier protein SCaMC-1;Small calcium-binding mitochondrial carrier protein 1;Mitochondrial ATP-Mg/Pi carrier protein 1;Mitochondrial Ca(2+)-dependent solute carrier protein 1;Solute carrier family 25 member 24 SLC25A24;APC1;MCSC1;SCAMC1 Q6NUK1-1;Q6NUK1;Q6NUK1-2 ENST00000264128;ENST00000370041 2 0.75638 1.7127 0.78902 1.0026 1.1213 1.0401 AlaDh_PNT_C;AlaDh_PNT_N;PNTB cell part;cytoplasmic part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane part;mitochondrial membrane part;mitochondrial part;mitochondrial respiratory chain;organelle part;respiratory chain binding;catalytic activity;cation transmembrane transporter activity;NAD(P) transhydrogenase activity;NAD(P)+ transhydrogenase (AB-specific) activity;NAD(P)+ transhydrogenase (B-specific) activity;nucleotide binding;transporter activity acetyl-CoA metabolic process;catabolic process;cation transport;cellular process;coenzyme catabolic process;coenzyme metabolic process;hydrogen transport;ion transport;metabolic process;transport;tricarboxylic acid cycle Nicotinate and nicotinamide metabolism 16 16 16 19.4 19.4 19.4 113.89 0 312970000 177370000 135600000 4410 IPI:IPI00337541.3 NAD(P) transhydrogenase, mitochondrial;Nicotinamide nucleotide transhydrogenase;Pyridine nucleotide transhydrogenase NNT Q13423 ENST00000264663;ENST00000344920 K00324;K00325 1 0.629 1.6298 NaN 0.81574 1.1717 NaN binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;ion binding;magnesium ion binding;phosphatase activity;phosphoprotein phosphatase activity;phosphoric ester hydrolase activity;protein tyrosine phosphatase activity 3 3 3 26.7 26.7 26.7 20.109 0.00010763 7880900 4723600 3157300 4411 IPI:IPI00337556.1;IPI:IPI00385758.1;IPI:IPI00384628.1 Magnesium-dependent phosphatase 1 MDP1 Q86V88-1;Q86V88;Q86V88-2;Q86V88-3 ENST00000288087;ENST00000396833 3 NaN 1.5833 0.76749 NaN 1.0388 1.0512 Ank 4 4 4 35.5 35.5 35.5 19.651 3.1003E-12 30291000 17071000 13221000 4412 IPI:IPI00337574.4 Ankyrin repeat domain-containing protein 39 ANKRD39;HSPC200 Q53RE8 ENST00000393537 1 0.92386 1.9042 0.90481 1.2646 1.186 1.2371 Pkinase cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity chromatin organization;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;regulation of chromatin assembly or disassembly;response to DNA damage stimulus;response to stress 14 14 11 23.5 23.5 18.7 82.347 4.0024E-53 87798000 45366000 42432000 4414 IPI:IPI00337660.1;IPI:IPI00385652.1;IPI:IPI00337659.1 Serine/threonine-protein kinase tousled-like 2;Tousled-like kinase 2;PKU-alpha TLK2 Q86UE8-3;Q86UE8;Q86UE8-1;Q86UE8-2 ENST00000326270;ENST00000343388;ENST00000346027 K08864 3 0.65375 1.0871 0.61184 0.82157 0.73023 0.7668 Peptidase_S9 cell part;cytoplasm;intracellular part catalytic activity;endopeptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides;serine hydrolase activity;serine-type endopeptidase activity;serine-type peptidase activity biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis 14 14 14 27.2 27.2 27.2 81.224 4.3754E-220 767910000 423360000 344540000 4415 IPI:IPI00337741.4 Acylamino-acid-releasing enzyme;Acyl-peptide hydrolase;Acylaminoacyl-peptidase;Oxidized protein hydrolase APEH;D3F15S2;D3S48E;DNF15S2 P13798 ENST00000296456 K01303 1 0.82988 1.684 0.8237 1.1503 1.203 1.1099 Drf_FH3;Drf_GBD;FH2 cell part;cytoplasm;intracellular part actin binding;binding;cytoskeletal protein binding;enzyme binding;GTPase binding;protein binding;Ras GTPase binding;Rho GTPase binding;small GTPase binding actin cytoskeleton organization;actin filament-based process;cellular component organization;cellular process;cytoskeleton organization;organelle organization Wnt signaling pathway 2 2 2 2.3 2.3 2.3 123.47 0.00046644 5521300 3034500 2486900 4417 IPI:IPI00337800.3;IPI:IPI00337801.1;IPI:IPI00337802.4 Disheveled-associated activator of morphogenesis 1 DAAM1;KIAA0666 Q9Y4D1-1;Q9Y4D1;Q9Y4D1-2;Q9Y4D1-3 ENST00000351081;ENST00000358498;ENST00000360909;ENST00000395125 K04512 3 3.1373 15.484 NaN 4.1202 10.029 NaN HSP70 adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding response to biotic stimulus;response to chemical stimulus;response to organic substance;response to protein stimulus;response to stimulus;response to stress;response to unfolded protein Antigen processing and presentation;MAPK signaling pathway 8 2 2 15.4 4.5 4.5 71.027 2.3691E-194 1702300 989060 713270 4418 IPI:IPI00339269.1;IPI:IPI00011134.2 Heat shock 70 kDa protein 6;Heat shock 70 kDa protein B';Putative heat shock 70 kDa protein 7;Heat shock 70 kDa protein B HSPA6;HSP70B';HSPA7;HSP70B P17066;P48741 ENST00000309758 K03283 2 0.47671 0.78063 0.45329 0.61268 0.54221 0.57185 Helicase_C;HIRAN;SNF2_N;zf-C3HC4 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;DNA binding;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity;zinc ion binding biosynthetic process;chromatin organization;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;transcription 17 17 17 19.4 19.4 19.4 113.93 7.861E-203 220660000 127090000 93579000 4419 IPI:IPI00339381.3;IPI:IPI00759790.1 Helicase-like transcription factor;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3;Sucrose nonfermenting protein 2-like 3;DNA-binding protein/plasminogen activator inhibitor 1 regulator;HIP116;RING finger protein 80 HLTF;HIP116A;RNF80;SMARCA3;SNF2L3;ZBU1 Q14527-1;Q14527;Q14527-2 ENST00000310053;ENST00000392912;ENST00000392913 2 0.73009 1.404 0.72589 0.92631 0.98746 0.89653 adh_short cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part binding;catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;retinol dehydrogenase activity cellular process;fat-soluble vitamin metabolic process;isoprenoid metabolic process;lipid metabolic process;metabolic process;retinoid metabolic process;terpenoid metabolic process;vitamin A metabolic process;vitamin metabolic process Retinol metabolism 5 5 5 22.3 22.3 22.3 35.386 1.4408E-65 79644000 42850000 36794000 4420 IPI:IPI00339384.5;IPI:IPI00339385.1 Retinol dehydrogenase 11;Retinal reductase 1;Prostate short-chain dehydrogenase/reductase 1;Androgen-regulated short-chain dehydrogenase/reductase 1;HCV core-binding protein HCBP12 RDH11;ARSDR1;PSDR1;CGI-82 Q8TC12-1;Q8TC12;Q8TC12-2 ENST00000381346 K11152 2 0.8804 1.4844 0.88361 1.161 0.99567 1.1416 CHDCT2;CHDNT;Chromo;DUF1086;DUF1087;Helicase_C;PHD;SNF2_N cell part;chromatin;chromosomal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;nucleus;organelle;organelle part ATP binding;ATP-dependent DNA helicase activity;binding;catalytic activity;chromatin binding;DNA binding;DNA helicase activity;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding chromatin assembly or disassembly;chromatin organization;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 10 6 5 6.5 4.6 3.8 226.59 7.9402E-21 137270000 71335000 65931000 4421 IPI:IPI00373870.3;IPI:IPI00411592.2 Chromodomain-helicase-DNA-binding protein 3;ATP-dependent helicase CHD3;Mi-2 autoantigen 240 kDa protein;Mi2-alpha;Zinc finger helicase CHD3 Q12873-1;Q12873;Q12873-2 ENST00000330494;ENST00000358181;ENST00000380358 K11642 2 0.81188 1.3638 0.7519 1.0187 0.96987 0.95447 AKAP95 cell part;intracellular organelle part;intracellular part;nuclear matrix;nuclear part;organelle part binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 9 9 9 22 22 22 65.653 1.2053E-100 416840000 215430000 201410000 4422 IPI:IPI00373877.3 Zinc finger protein 326 ZNF326 Q5BKZ1-1;Q5BKZ1 ENST00000340281;ENST00000361911;ENST00000394590 1 NaN 1.3169 NaN NaN 0.82865 NaN HEAT;TIP120 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle transcription activator activity;transcription regulator activity catabolic process;macromolecule catabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;proteolysis;regulation of transcription, DNA-dependent;transcription 4 2 2 3.2 1.9 1.9 135.25 3.2476E-12 57721 33273 24448 4424 IPI:IPI00791537.3;IPI:IPI00374208.3 Cullin-associated NEDD8-dissociated protein 2;Cullin-associated and neddylation-dissociated protein 2;p120 CAND2 CAND2;KIAA0667 O75155-1;O75155;O75155-2 ENST00000295989 2 0.8479 1.7064 0.85878 1.0454 1.1935 1.1071 5 5 5 23.8 23.8 23.8 33.62 3.0792E-90 30771000 15761000 15011000 4425 IPI:IPI00374272.3 UPF0600 protein C5orf51 C5orf51 A6NDU8 ENST00000381647 1 0.74607 1.4474 0.62642 0.93828 0.97955 0.79007 Exo_endo_phos cell part;cell projection;cytoplasmic part;cytosol;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;neuron projection;organelle binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;inositol bisphosphate phosphatase activity;inositol or phosphatidylinositol phosphatase activity;inositol-polyphosphate 5-phosphatase activity;protein binding actin cytoskeleton organization;actin filament-based process;cellular component organization;cellular process;cytoskeleton organization;organelle organization 2 2 2 4.5 4.5 4.5 51.09 6.9118E-09 21637000 11638000 9999000 4426 IPI:IPI00374574.2;IPI:IPI00374575.2 Inositol polyphosphate 5-phosphatase K;Skeletal muscle and kidney-enriched inositol phosphatase INPP5K;PPS;SKIP Q9BT40-1;Q9BT40;Q9BT40-2 ENST00000320345;ENST00000350761;ENST00000397335 2 0.80785 1.5862 0.79511 1.0875 1.0232 1.0501 CD47;V-set_CD47 cell part;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part binding;molecular transducer activity;protein binding;receptor activity;signal transducer activity;thrombospondin receptor activity cell adhesion;cell communication;positive regulation of immune system process;positive regulation of leukocyte activation;regulation of immune system process;regulation of leukocyte activation;signal transduction ECM-receptor interaction 6 6 6 13 13 13 35.213 3.3017E-15 466100000 247360000 218740000 4427 IPI:IPI00374740.3;IPI:IPI00216516.4;IPI:IPI00872082.1;IPI:IPI00216514.6 Leukocyte surface antigen CD47;Integrin-associated protein;Antigenic surface determinant protein OA3;Protein MER6 CD47;MER6 Q08722-1;Q08722;Q08722-4;Q08722-3;Q08722-2 ENST00000355354;ENST00000361309;ENST00000398257;ENST00000398258;ENST00000398260 K06266 4 0.717 1.1817 0.77483 0.91673 0.82102 0.93002 dUTPase cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;nucleus;organelle binding;catalytic activity;dUTP diphosphatase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;magnesium ion binding;pyrophosphatase activity alcohol metabolic process;carbohydrate metabolic process;D-ribose metabolic process;monosaccharide metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;pyrimidine nucleoside metabolic process Pyrimidine metabolism 10 10 1 73.8 73.8 7.9 17.748 7.5081E-144 3142900000 1599000000 1543900000 4428 IPI:IPI00375015.3 Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial;dUTP pyrophosphatase DUT P33316-2;P33316 ENST00000249783;ENST00000331200 K01520 1 0.68086 1.4688 NaN 0.90177 0.97961 NaN RRM_1 cell part;cytoplasmic part;cytosol;eukaryotic translation initiation factor 4F complex;intracellular part;macromolecular complex;perinuclear region of cytoplasm;protein complex binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;regulation of biosynthetic process;regulation of gene expression;regulation of translation;regulation of translational initiation;translation 6 1 1 25.9 3.4 3.4 32.604 2.1401E-139 11687000 6242600 5444600 4429 IPI:IPI00375127.4 Eukaryotic translation initiation factor 4H;Williams-Beuren syndrome chromosomal region 1 protein EIF4H;KIAA0038;WBSCR1;WSCR1 Q15056-2;Q15056 ENST00000265753;ENST00000353999 1 0.81334 1.6267 0.82994 1.1075 1.0306 1.1105 WAPL cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding interspecies interaction between organisms;multi-organism process 14 14 14 15.5 15.5 15.5 142.52 2.6538E-150 124090000 67720000 56374000 4431 IPI:IPI00412441.4;IPI:IPI00744918.3;IPI:IPI00375330.6 Wings apart-like protein homolog;Friend of EBNA2 protein WAPAL;FOE;KIAA0261;WAPL Q7Z5K2-3;Q7Z5K2;Q7Z5K2-2;Q7Z5K2-1 ENST00000298767;ENST00000342368;ENST00000372076 3 0.70539 1.5629 0.73545 0.99962 0.97354 1.0345 AAA;BRCT;RFC1 cell part;chromosomal part;DNA replication factor C complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;protein complex ATP binding;binding;catalytic activity;DNA binding;DNA clamp loader activity;DNA-dependent ATPase activity;enzyme activator activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding DNA metabolic process;DNA replication;DNA-dependent DNA replication;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleotide-excision repair, DNA gap filling;RNA-dependent DNA replication;telomere maintenance;transcription DNA replication;Mismatch repair;Nucleotide excision repair 13 13 13 13.3 13.3 13.3 128.25 3.524E-66 100340000 54292000 46046000 4432 IPI:IPI00375358.2;IPI:IPI00375359.2 Replication factor C subunit 1;Activator 1 subunit 1;Replication factor C large subunit;RF-C 140 kDa subunit;Activator 1 140 kDa subunit;Activator 1 large subunit;DNA-binding protein PO-GA RFC1;RFC140 P35251-1;P35251;P35251-2 ENST00000349703;ENST00000381897 K10754 2 0.94741 1.7681 1.002 1.1986 1.1821 1.2262 DUF1897;KH_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;protein binding;RNA binding;single-stranded DNA binding;structure-specific DNA binding;transcription factor activity;transcription regulator activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent 25 22 2 49.5 46.3 7 67.56 0 4654200000 2294600000 2359600000 4433 IPI:IPI00375441.2 Far upstream element-binding protein 1;DNA helicase V;HDH V FUBP1 Q96AE4-1;Q96AE4 ENST00000370767;ENST00000370768;ENST00000370773 1 0.78477 1.7849 0.81391 1.0631 1.1407 1.1337 RRM_1 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;nucleotide binding;protein binding cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 9 9 9 20.8 20.8 20.8 71.649 1.523E-159 211920000 111770000 100150000 4434 IPI:IPI00375462.1;IPI:IPI00103497.1 Splicing factor, arginine/serine-rich 12;Serine-arginine-rich-splicing regulatory protein 86;Splicing regulatory protein 508 SFRS12;SRRP86 Q8WXA9-2;Q8WXA9 ENST00000284041;ENST00000334121;ENST00000380918 2 1.1513 2.0589 1.3403 1.4927 1.3971 1.6811 JmjC cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen;protein binding cellular component organization;cellular process;chromatin modification;chromatin organization;metabolic process;organelle organization;protein amino acid dealkylation;protein amino acid demethylation;protein modification process 5 5 5 11.6 11.6 11.6 47.626 1.2113E-21 49360000 23869000 25491000 4435 IPI:IPI00604598.1;IPI:IPI00550958.2;IPI:IPI00375496.4 Histone arginine demethylase JMJD6;JmjC domain-containing protein 6;Jumonji domain-containing protein 6;Protein PTDSR;Phosphatidylserine receptor JMJD6;KIAA0585;PTDSR Q6NYC1-3;Q6NYC1;Q6NYC1-1;Q6NYC1-2 ENST00000303996;ENST00000344991;ENST00000397625 3 NaN NaN 0.54812 NaN NaN 0.75256 zf-C2H2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;protein binding;transcription coactivator activity;transcription cofactor activity;transcription corepressor activity;transcription factor activity;transcription factor binding;zinc ion binding immune system process;negative regulation of transcription from RNA polymerase II promoter;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 2 2 2 2.1 2.1 2.1 124.07 1.0709E-23 62504000 37438000 25066000 4436 IPI:IPI00375505.3 Zinc finger E-box-binding homeobox 1;Transcription factor 8;NIL-2-A zinc finger protein;Negative regulator of IL2 ZEB1;AREB6;TCF8 P37275 ENST00000320985;ENST00000360572 1 1.0091 2.1772 0.84682 1.3975 1.3918 1.1204 centrosome;cytoplasmic part;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;microtubule organizing center;non-membrane-bounded organelle;organelle;organelle part cellular component organization;cellular process;centrosome duplication;centrosome organization;microtubule organizing center organization;organelle organization 6 6 6 13.4 13.4 13.4 74.396 1.6053E-81 7817800 4519100 3298700 4437 IPI:IPI00375578.1 Spindle assembly abnormal protein 6 homolog SASS6;SAS6 Q6UVJ0 ENST00000287482 1 0.80458 1.6364 0.81986 1.0597 1.1358 0.97503 ubiquitin cell part;cytoplasm;extracellular region part;extracellular space;intracellular part binding;protein binding catabolic process;cell communication;cell-cell signaling;cellular process;macromolecule catabolic process;metabolic process;protein metabolic process;protein modification process;proteolysis;response to biotic stimulus;response to virus 5 5 5 30.3 30.3 30.3 17.887 1.4454E-201 142360000 76767000 65596000 4439 IPI:IPI00375631.6 Interferon-induced 17 kDa protein;Ubiquitin cross-reactive protein;Interferon-induced 15 kDa protein ISG15;G1P2;UCRP P05161 ENST00000379389 K12159 1 0.84303 1.6483 1.1338 1.1609 1.1628 1.3715 SAPS cell part;cytoplasm;intracellular part binding;protein binding 6 6 6 8.1 8.1 8.1 104.94 3.6943E-54 61746000 31089000 30657000 4441 IPI:IPI00414872.4;IPI:IPI00939295.1;IPI:IPI00853540.1;IPI:IPI00853587.1;IPI:IPI00375638.7;IPI:IPI00942736.1 Serine/threonine-protein phosphatase 6 regulatory subunit 2;SAPS domain family member 2 SAPS2;KIAA0685;PP6R2 O75170-1;O75170;O75170-5;O75170-3;O75170-4;O75170-2;O75170-6 ENST00000216061;ENST00000395746 6 1.1734 2.2157 1.106 1.5786 1.4281 1.4304 Ferritin cytoplasmic part;cytosolic part;cytosolic small ribosomal subunit;intracellular ferritin complex;intracellular part;macromolecular complex;organelle part;protein complex;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit binding;catalytic activity;cation binding;ferric iron binding;identical protein binding;ion binding;iron ion binding;metal ion binding;oxidoreductase activity;protein binding;transition metal ion binding cation transport;cellular homeostasis;cellular ion homeostasis;cellular iron ion homeostasis;cellular process;di-, tri-valent inorganic cation transport;ion transport;iron ion transport;metal ion transport;transition metal ion transport;transport 5 5 5 32.6 32.6 32.6 20.019 1.5543E-50 253340000 129670000 123680000 4443 IPI:IPI00375676.8 Ferritin light chain FTL P02792 ENST00000331825 1 0.64874 1.3114 0.73883 0.79543 0.95973 0.92079 Ribosomal_L21p intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;mitochondrion;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome binding;nucleic acid binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 4 4 4 24.4 24.4 24.4 23.159 7.4711E-08 80005000 41963000 38042000 4444 IPI:IPI00375677.1 39S ribosomal protein L21, mitochondrial MRPL21 Q7Z2W9 ENST00000362034 1 0.41253 0.8392 0.52912 0.5203 0.60983 0.64115 DUF1683 3 3 3 3 3 3 128.88 1.9419E-13 15164000 8944000 6220000 4445 IPI:IPI00396048.4;IPI:IPI00375684.6;IPI:IPI00412941.4;IPI:IPI00903192.1 UPF0636 protein C4orf41 C4orf41 Q7Z392-1;Q7Z392;Q7Z392-3;Q7Z392-4 ENST00000334690 4 0.80513 1.5495 0.84373 1.0684 1.0039 1.0483 G-patch;RRM_1;zf-RanBP cell part;chromatin remodeling complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex binding;cation binding;ion binding;metal ion binding;nucleic acid binding;nucleotide binding;RNA binding;transition metal ion binding;zinc ion binding cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 15 15 15 18.1 18.1 18.1 110.34 2.578E-181 260840000 135170000 125670000 4446 IPI:IPI00375731.1;IPI:IPI00915253.1;IPI:IPI00549342.2;IPI:IPI00916428.1 RNA-binding protein 10;RNA-binding motif protein 10;G patch domain-containing protein 9;RNA-binding protein S1-1 RBM10;DXS8237E;GPATC9;GPATCH9;KIAA0122 P98175-1;P98175;P98175-2;P98175-3;P98175-4 ENST00000377604 4 0.92396 1.6517 NaN 1.2385 1.1648 NaN GRIP;Ran_BP1;TPR_1 binding establishment of localization;establishment of localization in cell;intracellular transport;transport 16 2 1 8.7 1.2 0.6 198.19 4.5111E-67 6450100 3520100 2930000 4447 IPI:IPI00375793.6 RANBP2-like and GRIP domain-containing protein 4 RGPD4;RGP4 Q7Z3J3-1;Q7Z3J3 ENST00000354986 1 0.68154 0.74272 0.71845 0.93367 0.4989 0.90116 DUF537 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;microbody;organelle;peroxisome binding;nucleic acid binding;nucleotide binding;RNA binding 5 5 5 3.6 3.6 3.6 192.68 9.5113E-09 11145000 5798100 5347300 4448 IPI:IPI00375814.4;IPI:IPI00792904.1;IPI:IPI00942855.1;IPI:IPI00828177.2;IPI:IPI00005146.3;IPI:IPI00941715.1 Limkain-b1 LKAP;KIAA0430 Q9Y4F3-5;Q9Y4F3;Q9Y4F3-1;Q9Y4F3-4;Q9Y4F3-3 ENST00000344181;ENST00000396368 6 0.14761 NaN NaN 0.18148 NaN NaN catalytic activity 2 2 2 4.2 4.2 4.2 84.673 2.7393E-12 746620 574160 172460 4449 IPI:IPI00375836.2;IPI:IPI00827905.1 Protein FAM111B;Cancer-associated nucleoprotein FAM111B;CANP Q6SJ93-1;Q6SJ93;Q6SJ93-2 ENST00000343597 2 0.82645 1.3884 0.86917 1.0737 0.96137 1.1427 cell part;cytoplasmic part;endoplasmic reticulum;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane part;membrane-bounded organelle;organelle 2 2 2 4.5 4.5 4.5 67.038 9.5448E-09 18968000 9307200 9660500 4450 IPI:IPI00375879.6 Uncharacterized protein KIAA1467 KIAA1467 A2RU67 ENST00000197268 1 0.87086 1.4926 0.74437 1.1441 1.0141 0.96182 WD40 2 2 2 1.1 1.1 1.1 123.41 0.0065415 724010000 393220000 330790000 4451 IPI:IPI00375927.2 WD repeat-containing protein 72 WDR72 Q3MJ13 ENST00000360509;ENST00000396328 1 NaN 1.8457 NaN NaN 1.2932 NaN HCaRG cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding 2 2 2 20.4 20.4 20.4 10.907 1.6067E-06 1398700 817500 581220 4452 IPI:IPI00409561.1;IPI:IPI00375957.3 COMM domain-containing protein 6 COMMD6;MSTP076 Q7Z4G1-2;Q7Z4G1;Q7Z4G1-1 ENST00000355801;ENST00000377612;ENST00000377615;ENST00000377619 2 0.56406 0.97691 0.56228 0.74955 0.66872 0.74775 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 14 14 12 42.4 42.4 38 61.024 1.8297E-256 976210000 188850000 787360000 4455 IPI:IPI00376199.4;IPI:IPI00889619.2;IPI:IPI00646970.2 Interferon regulatory factor 2-binding protein 2 IRF2BP2 Q7Z5L9-1;Q7Z5L9;Q7Z5L9-2 ENST00000366609 3 0.49203 1.2108 0.56763 0.66824 0.74352 0.72185 PH;RA adherens junction;cell junction;cell projection;cell-substrate adherens junction;cell-substrate junction;cytoplasm;cytoskeleton;focal adhesion;intracellular organelle;lamellipodium;non-membrane-bounded organelle;organelle biological regulation;cell communication;cellular process;regulation of biological process;regulation of cellular process;signal transduction 7 7 6 14.7 14.7 13.4 73.182 3.5107E-53 141740000 78912000 62830000 4456 IPI:IPI00376219.1;IPI:IPI00871620.2;IPI:IPI00655588.1;IPI:IPI00743280.2 Amyloid beta A4 precursor protein-binding family B member 1-interacting protein;APBB1-interacting protein 1;Rap1-GTP-interacting adapter molecule;Proline-rich EVH1 ligand 1;Proline-rich protein 73;Retinoic acid-responsive proline-rich protein 1 APBB1IP;PREL1;RARP1;RIAM Q7Z5R6 ENST00000376236 4 NaN 1.6685 NaN NaN 1.0517 NaN Pacs-1 cell part;cytoplasmic part;cytosol;intracellular part binding;protein binding interspecies interaction between organisms;multi-organism process 3 3 3 5.2 5.2 5.2 109.34 5.4768E-26 643650 291130 352520 4457 IPI:IPI00456262.1;IPI:IPI00376229.1 Phosphofurin acidic cluster sorting protein 1 PACS1;KIAA1175 Q6VY07-2;Q6VY07;Q6VY07-1 ENST00000320580 2 0.55603 1.0719 0.56181 0.73503 0.74561 0.7131 WD40 cell part;cytoplasmic mRNA processing body;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;ribonucleoprotein complex binding;protein binding 29 29 29 29.1 29.1 29.1 151.66 0 1240600000 621460000 619110000 4458 IPI:IPI00376317.4;IPI:IPI00641449.1 Enhancer of mRNA-decapping protein 4;Human enhancer of decapping large subunit;Autoantigen Ge-1;Autoantigen RCD-8 EDC4;HEDLS Q6P2E9-1;Q6P2E9;Q6P2E9-2 ENST00000041337;ENST00000358933 2 0.44498 NaN NaN 0.59534 NaN NaN DUF2351 cell part;cytoplasm;intracellular part catalytic activity;ligase activity catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 2 2 2 5.1 5.1 5.1 43.656 6.5037E-43 15911000 8493500 7417700 4459 IPI:IPI00376330.9 Ubiquitin-conjugating enzyme E2C-binding protein;UbcH10-binding protein with a HECT-like domain UBE2CBP;C6orf157;H10BH Q7Z6J8 ENST00000237186 1 0.41502 0.75539 0.44726 0.55609 0.49419 0.58687 IQ;Myosin_head;Myosin_TH1 cell part;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;myosin complex;organelle part;protein complex actin binding;ATP binding;binding;calmodulin binding;catalytic activity;cytoskeletal protein binding;hydrolase activity;motor activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity 28 28 25 27.7 27.7 24.4 131.98 5.2993E-240 411530000 234460000 177070000 4460 IPI:IPI00376344.3;IPI:IPI00414980.2;IPI:IPI00855818.2 Myosin-Ib;Myosin I alpha;MMI-alpha;MYH-1c MYO1B O43795-1;O43795;O43795-2 ENST00000304164;ENST00000339514;ENST00000392318 K10356 3 NaN NaN 0.53996 NaN NaN 0.72173 Methyltransf_12 catalytic activity;methyltransferase activity;transferase activity;transferase activity, transferring one-carbon groups 4 1 1 14 4 4 43.537 1.9902E-07 6018700 3436200 2582500 4462 IPI:IPI00376351.4 Methyltransferase-like protein 2A METTL2A;METTL2;HSPC266 Q96IZ6-1;Q96IZ6 ENST00000262432;ENST00000311506 1 0.72175 1.6701 0.85673 0.98317 1.0993 1.173 Evr1_Alr;Thioredoxin cell part;extracellular region;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;nuclear membrane;nuclear part;organelle membrane;organelle part;plasma membrane catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on sulfur group of donors;oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor;thiol oxidase activity biological regulation;cell redox homeostasis;cellular homeostasis;cellular process;homeostatic process;metabolic process;oxidation reduction;regulation of biological process;regulation of biological quality;regulation of cellular process 3 3 3 4 4 4 77.528 2.7548E-14 16390000 8664100 7725800 4463 IPI:IPI00376394.4 Sulfhydryl oxidase 2;Quiescin Q6-like protein 1;Neuroblastoma-derived sulfhydryl oxidase QSOX2;QSCN6L1;SOXN Q6ZRP7 ENST00000358701 K10758 1 0.79257 1.5179 0.77399 1.0147 1.0167 1.0207 cytoplasmic part;intracellular part;large ribosomal subunit;macromolecular complex;mitochondrial large ribosomal subunit;mitochondrial part;organellar large ribosomal subunit;organelle part;ribonucleoprotein complex;ribosomal subunit structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 4 4 4 19.9 19.9 19.9 29.282 4.6933E-103 41424000 21415000 20009000 4464 IPI:IPI00376448.4 39S ribosomal protein L10, mitochondrial;MRP-L8 MRPL10;MRPL8;RPML8 Q7Z7H8 ENST00000290208;ENST00000351111 1 0.50626 NaN 0.67258 0.60036 NaN 0.87952 Cmc1 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle binding;cation binding;copper ion binding;ion binding;metal ion binding;transition metal ion binding 2 2 2 18.9 18.9 18.9 12.49 2.913E-08 91237000 52904000 38333000 4465 IPI:IPI00376478.4 COX assembly mitochondrial protein homolog CMC1;C3orf68 Q7Z7K0 ENST00000334841;ENST00000396610 1 0.88446 1.4485 0.7613 1.1083 0.98872 0.99818 GFA condensed chromosome kinetochore;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;kinetochore;macromolecular complex;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle carbon-sulfur lyase activity;catalytic activity;lyase activity anatomical structure formation;cellular component organization;cellular process;chromatin assembly or disassembly;chromatin modification;chromatin organization;chromatin remodeling;metabolic process;mitosis;nuclear division;organelle organization 6 6 6 33.1 33.1 33.1 29.946 2.5857E-206 468380000 244480000 223900000 4466 IPI:IPI00761082.1;IPI:IPI00376481.6;IPI:IPI00761119.1 Centromere protein V;Protein CENP-V;Proline-rich protein 6;Nuclear protein p30 CENPV;PRR6 Q7Z7K6-1;Q7Z7K6;Q7Z7K6-3;Q7Z7K6-2 ENST00000299736 3 0.7104 1.3989 0.69176 0.92542 0.93883 0.91455 Ribosomal_L5;Ribosomal_L5_C cytosolic large ribosomal subunit;intracellular non-membrane-bounded organelle;intracellular organelle;large ribosomal subunit;macromolecular complex;non-membrane-bounded organelle;nucleolus;organelle;ribonucleoprotein complex;ribosomal subunit binding;nucleic acid binding;protein binding;RNA binding;rRNA binding;structural constituent of ribosome;structural molecule activity intracellular protein transport;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein targeting;RNA processing;rRNA processing;translational elongation;transport Ribosome 14 14 2 66.3 66.3 8.4 20.252 4.4388E-182 3459800000 1898800000 1560900000 4467 IPI:IPI00376798.3 60S ribosomal protein L11;CLL-associated antigen KW-12 RPL11 P62913-1;P62913 ENST00000374550 K02868 1 0.86835 1.4329 1.7163 1.225 0.92069 2.2861 DDHD cell part;cytoplasm;intracellular part binding;catalytic activity;cation binding;hydrolase activity;ion binding;metal ion binding catabolic process;lipid catabolic process;lipid metabolic process;metabolic process;primary metabolic process 2,4-Dichlorobenzoate degradation;Alkaloid biosynthesis II 6 6 6 7.9 7.9 7.9 100.43 4.0973E-37 7511800 3247000 4264800 4468 IPI:IPI00376941.1;IPI:IPI00794129.1;IPI:IPI00376942.8 Phospholipase DDHD1;DDHD domain-containing protein 1;Phosphatidic acid-preferring phospholipase A1 homolog DDHD1;KIAA1705 Q8NEL9-1;Q8NEL9;Q8NEL9-2;Q8NEL9-3 ENST00000323669;ENST00000357758;ENST00000395610 K01066 3 0.4217 NaN 0.42858 0.54413 NaN 0.56846 Pkinase cell part;cytoplasm;intracellular part;membrane;plasma membrane ATP binding;binding;catalytic activity;cyclin-dependent protein kinase activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cellular biopolymer metabolic process;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process 4 3 3 7.8 6.3 6.3 59.582 5.9379E-14 2220000 1291500 928540 4469 IPI:IPI00376955.3;IPI:IPI00549858.6 Serine/threonine-protein kinase PCTAIRE-2;PCTAIRE-motif protein kinase 2;Serine/threonine-protein kinase PCTAIRE-1;PCTAIRE-motif protein kinase 1 PCTK2;PCTK1 Q00537;Q00536 ENST00000261211;ENST00000276052;ENST00000357227 K08820 2 NaN 1.8202 NaN NaN 1.1468 NaN DEK_C;DSPc cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle actin binding;binding;catalytic activity;cytoskeletal protein binding;hydrolase activity;phosphoprotein phosphatase activity;protein binding;protein tyrosine phosphatase activity;protein tyrosine/serine/threonine phosphatase activity cellular component organization;cellular process;cytoskeleton organization;metabolic process;organelle organization;phosphate metabolic process;phosphorus metabolic process;protein amino acid dephosphorylation;protein modification process Regulation of actin cytoskeleton 3 3 3 4.4 4.4 4.4 161.16 2.6571E-38 1125300 650120 475150 4470 IPI:IPI00377071.2;IPI:IPI00655806.1 Protein phosphatase Slingshot homolog 2;SSH-2L;hSSH-2L SSH2;KIAA1725;SSH2L Q76I76-1;Q76I76 ENST00000269033;ENST00000324677 K05766 2 0.95838 1.7749 0.75114 1.1983 1.2529 0.95489 NACHT cell part;cytoplasmic part;intracellular organelle part;intracellular part;membrane;mitochondrial membrane;mitochondrial outer membrane;mitochondrial part;organelle membrane;organelle outer membrane;organelle part;outer membrane adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding defense response;immune response;immune system process;innate immune response;interspecies interaction between organisms;multi-organism process;response to stimulus;response to stress 5 5 5 5.9 5.9 5.9 107.61 8.5361E-13 11145000 6042700 5101800 4471 IPI:IPI00465264.2;IPI:IPI00377214.1 NLR family member X1;Nucleotide-binding oligomerization domain protein 5;Nucleotide-binding oligomerization domain protein 9;Nucleotide-binding oligomerization domain protein 26;Protein Caterpiller 11.3 NLRX1;NOD26;NOD5;NOD9 Q86UT6-1;Q86UT6;Q86UT6-2 ENST00000292199;ENST00000409109;ENST00000409991 2 0.94338 1.834 0.91685 1.1663 1.1673 1.1576 KH_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;protein binding;RNA binding;transcription activator activity;transcription regulator activity biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 21 20 20 47.6 46 46 61.64 1.1627E-250 823380000 422920000 400460000 4472 IPI:IPI00377261.1;IPI:IPI00942585.1 Far upstream element-binding protein 3 FUBP3;FBP3 Q96I24-1;Q96I24 ENST00000319725;ENST00000372378 2 0.70851 1.205 0.71353 0.93412 0.81955 0.94841 Aminotran_4 branched-chain-amino-acid transaminase activity;catalytic activity;transaminase activity;transferase activity;transferase activity, transferring nitrogenous groups cell proliferation;cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;G1/S transition of mitotic cell cycle;metabolic process;nitrogen compound metabolic process;organic acid metabolic process Pantothenate and CoA biosynthesis;Valine, leucine and isoleucine biosynthesis;Valine, leucine and isoleucine degradation 8 8 8 24.6 24.6 24.6 44.1 7.616E-97 612080000 321570000 290510000 4473 IPI:IPI00382412.5 Branched-chain-amino-acid aminotransferase, cytosolic;Protein ECA39 BCAT1;BCT1;ECA39 P54687 ENST00000261192 K00826 1 1.8662 3.4445 1.8809 2.4984 2.2659 2.4963 HATPase_c;HSP90 cytoplasmic membrane-bounded vesicle;cytoplasmic part;cytoplasmic vesicle;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;melanosome;membrane-bounded organelle;membrane-bounded vesicle;organelle;vesicle adenyl nucleotide binding;ATP binding;binding;enzyme regulator activity;nitric-oxide synthase regulator activity;nucleoside binding;nucleotide binding;protein binding;protein domain specific binding;purine nucleoside binding;purine nucleotide binding cell communication;metabolic process;mitochondrial transport;protein complex assembly;protein folding;regulation of biosynthetic process;response to biotic stimulus;response to stress;response to unfolded protein;signal transduction;transport 74 74 51 54 54 43.4 98.16 0 118880000000 51958000000 66922000000 4474 IPI:IPI00382470.3;IPI:IPI00784295.2;IPI:IPI00031523.4;IPI:IPI00555876.1;IPI:IPI00555957.1 Heat shock protein HSP 90-alpha;HSP 86;Renal carcinoma antigen NY-REN-38 HSP90AA1;HSP90A;HSPC1;HSPCA P07900-2;P07900;P07900-1 ENST00000216281;ENST00000334701 5 0.61034 1.5958 0.75039 0.89219 1.0042 1.0463 DUF2051 cell part;cytoplasm;cytoskeleton;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle binding;DNA binding;double-stranded RNA binding;nucleic acid binding;protein binding;RNA binding;transcription regulator activity;transcription repressor activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 15 15 14 27.3 27.3 25.7 82.688 0 291820000 155380000 136450000 4475 IPI:IPI00382733.2;IPI:IPI00006207.2;IPI:IPI00785113.1 Leucine-rich repeat flightless-interacting protein 1;LRR FLII-interacting protein 1;TAR RNA-interacting protein;GC-binding factor 2 LRRFIP1;GCF2;TRIP Q32MZ4-3;Q32MZ4;Q32MZ4-2;Q32MZ4-1 ENST00000244815;ENST00000289175;ENST00000392000 3 0.9032 2.1502 1.2292 1.202 1.4522 1.6164 zf-RanBP cell part;cytoplasm;intracellular part binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding 2 2 2 7.5 7.5 7.5 39.949 2.1709E-12 12553000 5829200 6724000 4476 IPI:IPI00873534.1;IPI:IPI00382790.3;IPI:IPI00383511.2 Sharpin;Shank-associated RH domain-interacting protein;Shank-interacting protein-like 1 SHARPIN;SIPL1;PSEC0216 Q9H0F6-1;Q9H0F6;Q9H0F6-2;Q9H0F6-3 ENST00000321205;ENST00000361077;ENST00000398712 3 0.80861 1.6351 NaN 1.0115 1.1681 NaN cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;calcium ion binding;cation binding;ion binding;metal ion binding;protein binding cell communication;cell surface receptor linked signal transduction;enzyme linked receptor protein signaling pathway;protein complex assembly;signal transduction;transmembrane receptor protein tyrosine kinase signaling pathway 2 1 1 3.3 1.8 1.8 71.533 4.745E-06 6254000 3338700 2915300 4477 IPI:IPI00382936.1;IPI:IPI00332687.3 RalBP1-associated Eps domain-containing protein 2;RalBP1-interacting protein 2;Partner of RalBP1 REPS2;POB1 Q8NFH8-1;Q8NFH8;Q8NFH8-2 ENST00000303843;ENST00000357277 2 0.80308 1.2919 0.78157 0.98895 0.84151 0.96828 RNase_H1_sml cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle DNA replication 8 8 8 73.2 73.2 73.2 17.84 1.1327E-48 807340000 420990000 386360000 4478 IPI:IPI00382985.2;IPI:IPI00784761.1 Ribonuclease H2 subunit C;Ribonuclease HI subunit C;Aicardi-Goutieres syndrome 3 protein;RNase H1 small subunit RNASEH2C;AYP1 Q8TDP1-1;Q8TDP1;Q8TDP1-2 ENST00000308418 K10745 2 0.84931 1.5161 0.88187 1.137 1.0156 1.17 DUF55 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 13 13 13 48 48 48 25.697 6.5273E-108 877420000 442800000 434630000 4480 IPI:IPI00383163.5;IPI:IPI00399375.2 Thymocyte nuclear protein 1;Thymocyte protein Thy28 THYN1;THY28;HSPC144;MDS012;My0054 Q9P016-1;Q9P016;Q9P016-2 ENST00000341541;ENST00000352327;ENST00000392594;ENST00000392595 2 0.79246 1.6323 0.77834 1.0681 1.081 1.0065 Tcp11 cell part;cytoplasmic part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle 3 3 3 6.5 6.5 6.5 57.034 1.5656E-39 28229000 16018000 12211000 4482 IPI:IPI00383444.2 T-complex protein 11-like protein 1 TCP11L1 Q9NUJ3 ENST00000334274 1 0.76927 1.1784 NaN 1.0414 0.72035 NaN PH;RhoGAP cell part;intracellular enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity biological regulation;cell communication;cellular process;regulation of biological process;regulation of cellular process;signal transduction 4 4 4 7.7 7.7 7.7 72.43 2.8483E-25 6798000 3737000 3061000 4483 IPI:IPI00930670.1;IPI:IPI00383530.1;IPI:IPI00479720.3;IPI:IPI00400909.4 Rho GTPase-activating protein 25;Rho-type GTPase-activating protein 25 ARHGAP25;KIAA0053 P42331-3;P42331;P42331-2;P42331-4;P42331-1 ENST00000409030;ENST00000409202 4 0.48134 1.0812 0.39461 0.63386 0.68173 0.52029 Bromodomain;DDT;PHD;WAC_Acf1_DNA_bd cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 8 8 8 6.5 6.5 6.5 178.7 3.2431E-56 40124000 21847000 18277000 4484 IPI:IPI00412415.2;IPI:IPI00383565.5 Bromodomain adjacent to zinc finger domain protein 1A;ATP-utilizing chromatin assembly and remodeling factor 1;ATP-dependent chromatin-remodeling protein;Williams syndrome transcription factor-related chromatin-remodeling factor 180;CHRAC subunit ACF1 BAZ1A;ACF1;WCRF180;HSPC317 Q9NRL2-1;Q9NRL2;Q9NRL2-2 ENST00000358716;ENST00000360310;ENST00000382422 K11655 2 NaN NaN 0.89054 NaN NaN 1.1901 Glyco_hydro_31 cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;endoplasmic reticulum;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;melanosome;membrane-bounded organelle;membrane-bounded vesicle;organelle;vesicle binding;catalytic activity;glucan 1,3-alpha-glucosidase activity;hydrolase activity;hydrolase activity, acting on glycosyl bonds;hydrolase activity, hydrolyzing O-glycosyl compounds;protein binding carbohydrate metabolic process;metabolic process;primary metabolic process N-Glycan biosynthesis 33 1 1 38.1 2.1 2.1 112.92 0 45522000 23455000 22067000 4485 IPI:IPI00383581.4;IPI:IPI00441414.1 Neutral alpha-glucosidase AB;Glucosidase II subunit alpha;Alpha-glucosidase 2 GANAB;G2AN;KIAA0088 Q14697-1;Q14697;Q14697-3 ENST00000346178;ENST00000356638 K05546 2 0.81467 1.6116 NaN 1.0462 1.1716 NaN Band_3_cyto;HCO3_cotransp cell fraction;cell part;insoluble fraction;integral to membrane;intrinsic to membrane;membrane fraction;membrane part anion transmembrane transporter activity;bicarbonate transmembrane transporter activity;inorganic anion exchanger activity;inorganic anion transmembrane transporter activity;ion transmembrane transporter activity;transporter activity anion transport;establishment of localization;ion transport;transport 2 2 2 2.9 2.9 2.9 137.01 1.2222E-05 4422900 2381300 2041600 4486 IPI:IPI00383597.2;IPI:IPI00477139.1 Anion exchange protein 2;Non-erythroid band 3-like protein;Solute carrier family 4 member 2 SLC4A2;AE2;EPB3L1;HKB3;MPB3L P04920-1;P04920;P04920-2 ENST00000310317;ENST00000392826 2 0.62051 1.1217 0.6134 0.7477 0.8011 0.73751 SIR2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;NAD(P)+-protein-arginine ADP-ribosyltransferase activity;NAD+ ADP-ribosyltransferase activity;nucleotide binding;protein binding;transferase activity;transferase activity, transferring glycosyl groups;zinc ion binding chromatin silencing;metabolic process;protein amino acid ADP-ribosylation;protein amino acid deacetylation;protein modification process;regulation of biosynthetic process;regulation of transcription, DNA-dependent 2 2 2 7.3 7.3 7.3 39.118 2.799E-05 34641000 18409000 16232000 4487 IPI:IPI00383640.3;IPI:IPI00396170.4;IPI:IPI00556638.3 Mono-ADP-ribosyltransferase sirtuin-6;SIR2-like protein 6 SIRT6;SIR2L6 Q8N6T7-1;Q8N6T7;Q8N6T7-2;Q8N6T7-4 ENST00000269860;ENST00000305232;ENST00000337491;ENST00000381935 K11416 3 0.64022 0.95857 NaN 0.79398 0.58041 NaN La binding;nucleic acid binding;RNA binding 6 2 2 7.1 3.3 3.3 105.32 1.6756E-56 4749700 2489600 2260200 4488 IPI:IPI00383949.2;IPI:IPI00856120.1;IPI:IPI00855953.1;IPI:IPI00940348.1 La-related protein 2;La ribonucleoprotein domain family member 2 LARP2 Q659C4-1;Q659C4;Q659C4-2;Q659C4-9 ENST00000264584;ENST00000326639;ENST00000354456;ENST00000394288 4 NaN 1.2882 NaN NaN 0.83712 NaN endoplasmic reticulum;integral to membrane;integral to plasma membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;intrinsic to plasma membrane;membrane-bounded organelle;organelle binding;protein binding 3 1 1 53.6 23.8 23.8 9.1164 0.00052805 149000 68920 80082 4489 IPI:IPI00383952.1 Protein canopy homolog 2;MIR-interacting saposin-like protein;Transmembrane protein 4;Putative secreted protein ZSIG9 CNPY2;MSAP;TMEM4;ZSIG9;UNQ1943/PRO4426 Q9Y2B0-2;Q9Y2B0 ENST00000273308 1 0.79884 1.3723 0.82271 1.0842 0.88204 1.1224 NTP_transf_2;PAP_central;PAP_RNA-bind cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;nucleic acid binding;nucleoside binding;nucleotide binding;polynucleotide adenylyltransferase activity;purine nucleoside binding;RNA binding;transferase activity nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile;transcription 4 4 4 5 5 5 84.55 2.2049E-16 56156000 29158000 26998000 4490 IPI:IPI00384028.5;IPI:IPI00024525.3;IPI:IPI00384154.3 Poly(A) polymerase alpha;Polynucleotide adenylyltransferase alpha;Poly(A) polymerase beta;Polynucleotide adenylyltransferase beta;Testis-specific poly(A) polymerase PAPOLA;PAP;PAPOLB;PAPT P51003-1;P51003;Q9NRJ5;P51003-2 ENST00000216277;ENST00000404991 K00970 3 0.78305 1.676 NaN 0.97468 1.1173 NaN TRAPP cell part;cytoplasmic part;endoplasmic reticulum;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle cellular process;establishment of localization;transport;vesicle-mediated transport 5 5 5 37.3 37.3 37.3 17.983 4.0365E-159 18201000 9212700 8988300 4491 IPI:IPI00384047.1;IPI:IPI00329125.1 Trafficking protein particle complex subunit 6B TRAPPC6B Q86SZ2-1;Q86SZ2;Q86SZ2-2 ENST00000330149;ENST00000347691 2 0.75969 1.6341 0.87887 1.0272 1.1245 1.097 PA28_alpha;PA28_beta cell part;cytoplasmic part;cytosol;intracellular part;macromolecular complex;proteasome activator complex;protein complex proteasome activator activity;proteasome regulator activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Antigen processing and presentation;Proteasome 13 13 13 64.7 64.7 64.7 28.602 1.2865E-288 1902900000 1181300000 721610000 4492 IPI:IPI00384051.6 Proteasome activator complex subunit 2;Proteasome activator 28 subunit beta;Activator of multicatalytic protease subunit 2;11S regulator complex subunit beta PSME2 Q9UL46 ENST00000216802;ENST00000396881 K06697 1 0.75273 1.4476 NaN 1.0446 0.9129 NaN 9 2 2 16 4.6 4.6 80.654 1.0208E-38 29194000 16419000 12774000 4493 IPI:IPI00384080.2 Coiled-coil domain-containing protein 88B;Brain leucine zipper domain-containing protein;Hook-related protein 3 CCDC88B;BRLZ A6NC98-5;A6NC98 ENST00000356786;ENST00000394494 1 0.58943 1.2493 0.71195 0.76473 0.88564 1.0435 Sua5_yciO_yrdC cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;mitochondrion;organelle 9 9 9 42.7 42.7 42.7 29.328 2.0569E-84 113480000 63185000 50291000 4494 IPI:IPI00384180.4 YrdC domain-containing protein, mitochondrial;Ischemia/reperfusion-inducible protein homolog;Dopamine receptor-interacting protein 3 YRDC;DRIP3;IRIP Q86U90 ENST00000373044 1 NaN 2.5605 2.0091 NaN 1.5613 2.6902 binding;nucleic acid binding 2 2 2 6.3 6.3 6.3 32.825 0.00079671 6301000 3316300 2984700 4496 IPI:IPI00384210.3;IPI:IPI00784421.1;IPI:IPI00853248.1 Tudor domain-containing protein PHF20L1 PHF20L1;CGI-72 A8MW92-2;A8MW92;A8MW92-3;A8MW92-1 ENST00000315808;ENST00000337920;ENST00000361997;ENST00000395383;ENST00000395386 3 0.80638 1.9716 NaN 1.1751 1.1937 NaN DUF1875 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 2 2 1 7.3 7.3 5.2 32.377 0.0016346 13704000 6934800 6768700 4497 IPI:IPI00550575.2;IPI:IPI00384236.1 Nuclear receptor-binding factor 2;Comodulator of PPAR and RXR NRBF2;COPR Q96F24-1;Q96F24;Q96F24-2 ENST00000277746;ENST00000395241 2 0.79013 1.7401 0.77439 1.0437 1.182 1.024 Prenylcys_lyase;Pyr_redox_2 intracellular organelle;lysosome;lytic vacuole;macromolecular complex;membrane-bounded organelle;organelle;plasma lipoprotein particle;protein-lipid complex;triglyceride-rich lipoprotein particle;vacuole;very-low-density lipoprotein particle binding;catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on sulfur group of donors;oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor;prenylcysteine oxidase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;prenylated protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 11 11 11 21.6 21.6 21.6 56.639 1.8566E-126 125130000 71051000 54080000 4498 IPI:IPI00384280.5 Prenylcysteine oxidase 1;Prenylcysteine lyase PCYOX1;KIAA0908;PCL1;UNQ597/PRO1183 Q9UHG3 ENST00000264441 K05906 1 0.787 1.4987 0.76308 1.149 0.98144 1.0607 adh_short cell part;cytoplasm;intracellular part binding;catalytic activity;oxidoreductase activity metabolic process;oxidation reduction 2 2 2 7.6 7.6 7.6 25.301 0.0024288 313230000 165340000 147890000 4499 IPI:IPI00384297.3 Carbonyl reductase 4 CBR4 Q8N4T8-1;Q8N4T8 ENST00000306193 K11539 1 0.94065 2.0166 0.91792 1.2493 1.2869 1.222 cell part;cell projection;cytoplasmic part;intracellular part;perinuclear region of cytoplasm;ruffle catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;inositol or phosphatidylinositol phosphatase activity;lipid phosphatase activity;phosphatase activity;phosphatidylinositol-3-phosphatase activity 5 5 5 8.5 8.5 8.5 72.203 5.3629E-115 17874000 10077000 7797100 4500 IPI:IPI00168378.4;IPI:IPI00384329.3;IPI:IPI00152391.6 Myotubularin-related protein 14;HCV NS5A-transactivated protein 4 splice variant A-binding protein 1 MTMR14;C3orf29 Q8NCE2-1;Q8NCE2;Q8NCE2-2;Q8NCE2-3 ENST00000296003;ENST00000351233;ENST00000353332 3 1.2162 2.3899 1.28 1.6258 1.6489 1.6457 FYVE;PH;RhoGEF cell projection;cytoskeleton;Golgi apparatus;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;lamellipodium;membrane-bounded organelle;non-membrane-bounded organelle;organelle;ruffle binding;enzyme binding;enzyme regulator activity;guanyl-nucleotide exchange factor activity;protein binding;Ras guanyl-nucleotide exchange factor activity;Rho guanyl-nucleotide exchange factor activity;small GTPase regulator activity;zinc ion binding anatomical structure formation;cellular component organization;cellular process;cytoskeleton organization;organelle organization;regulation of anatomical structure morphogenesis;regulation of cell morphogenesis;regulation of cell shape Regulation of actin cytoskeleton 10 10 10 16.4 16.4 16.4 79.4 1.3088E-52 105580000 51799000 53784000 4501 IPI:IPI00384357.2;IPI:IPI00413785.5;IPI:IPI00024312.2;IPI:IPI00217865.2 FYVE, RhoGEF and PH domain-containing protein 3;Zinc finger FYVE domain-containing protein 5 FGD3;ZFYVE5 Q5JSP0-1;Q5JSP0;Q5JSP0-2 ENST00000337352;ENST00000375482 K05722 4 NaN 3.1093 0.8015 NaN 1.5865 1.0933 Tropomyosin actin filament bundle;actomyosin;bleb;cell projection;cell projection membrane;cytoplasmic part;cytoskeletal part;intracellular part;leading edge membrane;membrane part;muscle thin filament tropomyosin;organelle part;ruffle membrane;stress fiber actin binding;binding;cytoskeletal protein binding;protein binding;structural constituent of cytoskeleton;structural constituent of muscle;structural molecule activity cell motion;muscle contraction;muscle system process;positive regulation of heart rate by epinephrine;regulation of heart rate;regulation of heart rate by chemical signal;response to reactive oxygen species;system process;transport Cardiac muscle contraction 12 3 3 37.9 17.3 17.3 28.737 6.6846E-202 63247000 33834000 29413000 4502 IPI:IPI00384369.4;IPI:IPI00014581.1;IPI:IPI00216135.1;IPI:IPI00296039.7;IPI:IPI00915324.1;IPI:IPI00745267.2 Tropomyosin alpha-1 chain;Tropomyosin-1;Alpha-tropomyosin TPM1;C15orf13;TMSA P09493-5;P09493;P09493-1;P09493-3;P09493-4;P09493-6;P09493-2 ENST00000288398;ENST00000317516;ENST00000334895;ENST00000357980;ENST00000358278 K10373 6 0.78404 1.3897 0.85502 0.99362 0.87927 1.1713 DUF618 binding;protein binding 13 13 13 12.6 12.6 12.6 156.02 1.3615E-136 57373000 25980000 31392000 4503 IPI:IPI00384541.4;IPI:IPI00639879.2;IPI:IPI00760919.1;IPI:IPI00647267.1 Regulation of nuclear pre-mRNA domain-containing protein 2 RPRD2;KIAA0460;HSPC099 Q5VT52-1;Q5VT52;Q5VT52-3;Q5VT52-2 ENST00000369068;ENST00000401000;ENST00000401001 4 0.86518 1.5447 0.96051 1.1601 0.98799 1.2226 Pyridoxal_deC binding;carbon-carbon lyase activity;carboxy-lyase activity;catalytic activity;cofactor binding;lipid binding;lyase activity;protein binding;pyridoxal phosphate binding;steroid binding;vitamin B6 binding;vitamin binding carboxylic acid metabolic process;cellular ketone metabolic process;cellular metabolic process;cellular process;metabolic process;organic acid metabolic process;oxoacid metabolic process 8 8 8 14.5 14.5 14.5 86.706 2.4477E-90 37455000 20549000 16906000 4504 IPI:IPI00384689.3;IPI:IPI00384285.6;IPI:IPI00373856.11 Pyridoxal-dependent decarboxylase domain-containing protein 1 PDXDC1;KIAA0251 Q6P996-1;Q6P996 ENST00000325823 3 0.88784 1.4372 0.81201 1.1206 1.0155 1.0398 RRM_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;nucleotide binding;RNA binding anatomical structure morphogenesis;cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing 12 8 8 26.9 22.2 22.2 60.417 7.6948E-220 376650000 189090000 187560000 4506 IPI:IPI00915400.1;IPI:IPI00915287.1;IPI:IPI00915299.1;IPI:IPI00384710.8;IPI:IPI00470879.4 Regulator of differentiation 1 ROD1 O95758-4;O95758;O95758-5;O95758-3;O95758-2;O95758-1 ENST00000334318;ENST00000374255 5 NaN 0.74498 0.4988 NaN 0.485 0.66613 Pkinase cell fraction;endoplasmic reticulum membrane;endoplasmic reticulum part;Golgi apparatus part;Golgi membrane;insoluble fraction;intracellular part;membrane;membrane fraction;membrane part;nuclear part;nucleoplasm;organelle membrane;organelle part ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity mitosis;nuclear division;organelle organization;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;regulation of cyclin-dependent protein kinase activity;regulation of mitosis Cell cycle;Progesterone-mediated oocyte maturation 3 3 3 6.6 6.6 6.6 54.521 2.8013E-06 33115000 17307000 15808000 4507 IPI:IPI00384765.2 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase;Myt1 kinase PKMYT1;MYT1 Q99640 ENST00000262300;ENST00000402679 K06633 1 0.71127 1.4343 0.65646 0.92576 0.928 0.87384 Ank;ArfGap;GIT_SHD adherens junction;cell junction;cell-substrate adherens junction;cell-substrate junction;cytoplasm;cytoskeleton;focal adhesion;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle ARF GTPase activator activity;binding;cation binding;enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;ion binding;metal ion binding;protein binding;small GTPase regulator activity;zinc ion binding regulation of ARF GTPase activity;regulation of cell communication;regulation of G-protein coupled receptor protein signaling pathway;regulation of GTPase activity;regulation of Ras GTPase activity;regulation of signal transduction 15 15 12 29.3 29.3 25.4 84.34 1.5994E-135 254280000 137830000 116450000 4508 IPI:IPI00384861.3;IPI:IPI00383987.5 ARF GTPase-activating protein GIT1;G protein-coupled receptor kinase-interactor 1;GRK-interacting protein 1;Cool-associated and tyrosine-phosphorylated protein 1 GIT1 Q9Y2X7-1;Q9Y2X7 ENST00000225394;ENST00000335356;ENST00000394869 2 0.72958 1.4298 0.70093 0.98456 0.95728 0.94351 UAA cell part;cytoplasmic part;Golgi apparatus part;Golgi membrane;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity;nucleoside transmembrane transporter activity;purine nucleoside transmembrane transporter activity;signal transducer activity;transporter activity positive regulation of cell communication;positive regulation of protein kinase cascade;positive regulation of signal transduction;regulation of cell communication;regulation of protein kinase cascade;regulation of signal transduction;transport 4 4 4 7.6 7.6 7.6 47.514 1.2994E-09 132810000 74194000 58616000 4509 IPI:IPI00642271.2;IPI:IPI00384867.4;IPI:IPI00854750.1 Adenosine 3'-phospho 5'-phosphosulfate transporter 1;PAPS transporter 1;Solute carrier family 35 member B2;Putative MAPK-activating protein PM15;Putative NF-kappa-B-activating protein 48 SLC35B2;PAPST1;PSEC0149 Q8TB61-1;Q8TB61;Q8TB61-2;Q8TB61-3 ENST00000288373;ENST00000341553;ENST00000393812 3 0.70977 1.5305 NaN 1.0417 1.0372 NaN Ank;KAP_NTPase cell part;cytoplasmic part;cytosol;integral to membrane;intracellular part;intrinsic to membrane;membrane part biological regulation;cell communication;cellular process;intracellular signaling cascade;regulation of biological process;regulation of cellular process;signal transduction 7 7 7 4 4 4 196.54 9.6803E-29 3475200 1919800 1555400 4510 IPI:IPI00885055.1;IPI:IPI00885052.1;IPI:IPI00384909.3;IPI:IPI00884985.1;IPI:IPI00183964.4 Kinase D-interacting substrate of 220 kDa;Ankyrin repeat-rich membrane spanning protein KIDINS220;ARMS;KIAA1250 Q9ULH0-1;Q9ULH0;Q9ULH0-4;Q9ULH0-2;Q9ULH0-5 ENST00000256707;ENST00000319688 5 1.0754 1.506 NaN 1.3652 0.97203 NaN cell part;cytoplasm;cytoskeleton;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle binding;protein binding 5 5 5 6.4 6.4 6.4 120.96 1.2033E-13 49360000 15706000 33654000 4511 IPI:IPI00384972.3;IPI:IPI00748004.1 Uncharacterized protein KIAA1267 KIAA1267 Q7Z3B3-1;Q7Z3B3 ENST00000262419;ENST00000393476 2 0.64991 1.2792 0.67337 0.82441 0.83586 0.8273 NOG1;NOGCT cell part;cytoplasmic part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;perinuclear region of cytoplasm binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity metabolic process;negative regulation of cell adhesion;negative regulation of cell proliferation;negative regulation of DNA replication;regulation of biosynthetic process;regulation of cyclin-dependent protein kinase activity;regulation of DNA replication 23 23 23 42 42 42 73.964 1.2831E-185 898330000 486660000 411670000 4512 IPI:IPI00385042.4 Nucleolar GTP-binding protein 1;Chronic renal failure gene protein;GTP-binding protein NGB GTPBP4;CRFG;NOG1 Q9BZE4 ENST00000360059;ENST00000360803 1 0.74606 1.3292 0.78653 0.94571 0.93378 0.97256 BID cell fraction;cytoplasmic part;cytosol;insoluble fraction;intracellular part;membrane;membrane fraction;mitochondrial membrane;mitochondrial outer membrane;mitochondrial part;organelle membrane;organelle outer membrane;organelle part;outer membrane binding;cytokine receptor binding;death receptor binding;protein binding;receptor binding;tumor necrosis factor receptor superfamily binding apoptosis;cell death;induction of apoptosis;induction of apoptosis by extracellular signals;induction of apoptosis via death domain receptors;mitochondrion organization;organelle organization;release of cytochrome c from mitochondria Alzheimer's disease;Amyotrophic lateral sclerosis (ALS);Apoptosis;Natural killer cell mediated cytotoxicity;p53 signaling pathway;Pathways in cancer 2 1 1 28.5 8 8 14.62 1.2905E-08 18528000 9691600 8836500 4513 IPI:IPI00385121.1 BH3-interacting domain death agonist;p22 BID;BH3-interacting domain death agonist p15;p15 BID;BH3-interacting domain death agonist p13;p13 BID;BH3-interacting domain death agonist p11;p11 BID BID P55957-3;P55957 ENST00000317361;ENST00000337587;ENST00000344090;ENST00000399761;ENST00000399767;ENST00000399774 K04726 1 0.73046 1.3325 0.73276 1.0067 0.87707 0.99627 SRP54;SRP-alpha_N integral to membrane;intrinsic to membrane;macromolecular complex;organelle part;protein complex;receptor complex;ribonucleoprotein complex;signal recognition particle receptor complex;signal recognition particle, endoplasmic reticulum targeting 7S RNA binding;binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;nucleic acid binding;nucleotide binding;pyrophosphatase activity;receptor activity;RNA binding;signal recognition particle binding;signal transducer activity cotranslational protein targeting to membrane;intracellular protein transport;protein targeting;protein targeting to ER;protein targeting to membrane;protein transport;SRP-dependent cotranslational protein targeting to membrane;transport Bacterial secretion system;Protein export 9 9 9 19.1 19.1 19.1 69.81 4.6065E-71 102260000 76003000 26255000 4516 IPI:IPI00385267.4 Signal recognition particle receptor subunit alpha;Docking protein alpha SRPR P08240 ENST00000332118 K03110 1 0.52092 1.3533 0.51104 0.72767 0.82553 0.68619 C1_1;C2;Pkinase;Pkinase_C cell fraction;cell part;cytoplasmic part;cytosol;insoluble fraction;intracellular part;membrane;membrane fraction;plasma membrane adenyl nucleotide binding;ATP binding;binding;calcium ion binding;diacylglycerol binding;lipid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;ribonucleotide binding;zinc ion binding cellular process;induction of apoptosis;induction of apoptosis by extracellular signals;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;regulation of cell death Calcium signaling pathway;ErbB signaling pathway;Focal adhesion;Gap junction;Glioma;Leukocyte transendothelial migration;Long-term depression;Long-term potentiation;MAPK signaling pathway;MAPK signaling pathway - yeast;Melanogenesis;Natural killer cell mediated cytotoxicity;Non-small cell lung cancer;Pathways in cancer;Phosphatidylinositol signaling system;Tight junction;Vascular smooth muscle contraction;VEGF signaling pathway;Vibrio cholerae infection;Wnt signaling pathway 10 10 4 15.8 15.8 5.5 76.763 1.4588E-87 88726000 52799000 35927000 4517 IPI:IPI00385449.4 Protein kinase C alpha type PRKCA;PKCA;PRKACA P17252 ENST00000284384 K02677 1 0.67752 1.4877 0.97765 0.89063 0.98321 1.2556 APC10;efhand;ZZ anaphase-promoting complex;cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nuclear ubiquitin ligase complex;organelle part;protein complex;ubiquitin ligase complex binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding regulation of biological process;regulation of cell cycle process;regulation of cellular process;regulation of mitosis;regulation of mitotic cell cycle;regulation of mitotic metaphase/anaphase transition;regulation of organelle organization 9 9 9 3.9 3.9 3.9 331.07 2.2306E-90 21526000 11157000 10370000 4519 IPI:IPI00385631.7;IPI:IPI00790964.3;IPI:IPI00847913.2 Zinc finger ZZ-type and EF-hand domain-containing protein 1 ZZEF1;KIAA0399 O43149-1;O43149;O43149-2;O43149-3 ENST00000381638 3 0.89106 0.44994 NaN 1.1231 0.31343 NaN Myb_DNA-binding cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;nucleoplasm;organelle;organelle part binding;DNA binding;nucleic acid binding;transcription regulator activity;transcription termination factor activity negative regulation of biosynthetic process;negative regulation of DNA replication;regulation of biosynthetic process;regulation of DNA replication;regulation of transcription, DNA-dependent;transcription termination 3 3 3 4.1 4.1 4.1 103.05 4.1009E-43 8338100 3557200 4780900 4520 IPI:IPI00385712.3 Transcription termination factor 1;TTF-I;RNA polymerase I termination factor TTF1 Q15361 ENST00000334270;ENST00000403124 1 NaN 1.081 0.55617 NaN 0.70179 0.73544 MMR_HSR1 binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding 4 4 4 8.2 8.2 8.2 78.457 3.3852E-69 5100300 2727800 2372500 4521 IPI:IPI00385928.2 Uncharacterized protein C4orf14 C4orf14 Q8NC60 ENST00000264230 1 NaN 1.4103 NaN NaN 0.88228 NaN Pyr_redox_2 catalytic activity;oxidoreductase activity metabolic process;oxidation reduction 3 3 3 5.2 5.2 5.2 55.792 5.6853E-47 1500600 848590 652040 4522 IPI:IPI00385950.7 Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 PYROXD1 Q8WU10 ENST00000240651 1 0.93851 1.8008 0.94875 1.1631 1.2919 1.1735 Lipase_3 cell part;integral to membrane;intrinsic to membrane;membrane;membrane part;plasma membrane binding;calcium ion binding;carboxylesterase activity;catalytic activity;cation binding;hydrolase activity;hydrolase activity, acting on ester bonds;ion binding;lipase activity;metal ion binding;triacylglycerol lipase activity catabolic process;lipid catabolic process;lipid metabolic process;metabolic process;primary metabolic process 5 5 5 9.1 9.1 9.1 73.731 1.7333E-09 37722000 19099000 18623000 4523 IPI:IPI00385987.6;IPI:IPI00909319.2;IPI:IPI00785012.1 Sn1-specific diacylglycerol lipase beta;KCCR13L DAGLB Q8NCG7-1;Q8NCG7;Q8NCG7-2 ENST00000297056 3 0.79343 1.797 NaN 0.99245 1.0728 NaN Glycos_transf_1 cell fraction;cytoplasmic part;insoluble fraction;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane fraction;membrane part;membrane-bounded organelle;nucleus;organelle alpha-1,3-mannosyltransferase activity;binding;catalytic activity;mannosyltransferase activity;protein anchor;protein binding;transferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring hexosyl groups carbohydrate metabolic process;cellular process;dolichol-linked oligosaccharide biosynthetic process;metabolic process;protein amino acid glycosylation;protein amino acid N-linked glycosylation;protein localization;protein modification process N-Glycan biosynthesis 3 3 3 10.3 10.3 10.3 47.091 7.1449E-06 2087800 1176900 910810 4525 IPI:IPI00386072.3;IPI:IPI00171443.1 Alpha-1,3-mannosyltransferase ALG2;GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase;Asparagine-linked glycosylation protein 2 ALG2;UNQ666/PRO1298 Q9H553-1;Q9H553;Q9H553-2 ENST00000238477;ENST00000319033 K03843 2 0.62003 1.6669 0.66879 0.83046 1.0934 0.88671 KH_1;zf-CCHC cytoplasmic part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;organelle;organelle part;ribonucleoprotein complex;ribosome;spliceosomal complex binding;nucleic acid binding;protein binding;RNA binding;RNA polymerase II transcription factor activity;transcription cofactor activity;transcription corepressor activity;transcription factor binding;transcription repressor activity;zinc ion binding metabolic process;mRNA splice site selection;nitrogen compound metabolic process;nuclear mRNA 3'-splice site recognition;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 9 1 1 19.9 1.7 1.7 80.62 2.1905E-141 16942000 8709200 8232800 4526 IPI:IPI00386119.4 Splicing factor 1;Zinc finger protein 162;Transcription factor ZFM1;Zinc finger gene in MEN1 locus;Mammalian branch point-binding protein mBBP SF1;ZFM1;ZNF162 Q15637-5;Q15637 ENST00000227503;ENST00000334944;ENST00000377387;ENST00000377390 1 0.82691 1.4357 NaN 1.0768 0.97728 NaN cell part;cytoplasm;intracellular part;membrane;plasma membrane actin binding;binding;cytoskeletal protein binding;protein binding 2 2 2 1.7 1.7 1.7 138.38 3.9617E-05 2256200 1263400 992740 4529 IPI:IPI00400812.5;IPI:IPI00386170.3;IPI:IPI00830086.1 Sperm-specific antigen 2;Cleavage signal-1 protein;Ki-ras-induced actin-interacting protein SSFA2;CS1;KIAA1927;KRAP P28290-1;P28290;P28290-3;P28290-2 ENST00000261006;ENST00000320370 3 0.75437 1.4404 0.74353 0.99528 0.9561 0.96486 TPR_2 cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex binding;protein binding angiogenesis;N-terminal protein amino acid acetylation;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein amino acid acetylation;protein modification process;regulation of transcription, DNA-dependent;transcription 40 40 2 46.4 46.4 2 101.27 0 2334400000 1244100000 1090300000 4530 IPI:IPI00386189.2 NMDA receptor-regulated protein 1;N-terminal acetyltransferase;Protein tubedown-1;Tbdn100;Gastric cancer antigen Ga19 NARG1;GA19;NATH;TBDN100 Q9BXJ9-1;Q9BXJ9 ENST00000296543 1 1.1528 1.9131 1.0331 1.4315 1.3851 1.2745 Mito_carr cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part binding;protein binding activation of caspase activity;cellular process;positive regulation of cell death;positive regulation of peptidase activity;regulation of cell communication;regulation of cell death;regulation of signal transduction;transport 4 4 4 10.5 10.5 10.5 41.544 7.8103E-18 44302000 23477000 20824000 4532 IPI:IPI00386258.1;IPI:IPI00479697.1;IPI:IPI00739665.1 Mitochondrial carrier homolog 1;Presenilin-associated protein MTCH1;PSAP;CGI-64;UNQ1871/PRO4314 Q9NZJ7-1;Q9NZJ7;Q9NZJ7-2;Q9NZJ7-3 ENST00000373616;ENST00000373627 3 0.72203 1.5123 0.68039 0.9476 1.0391 0.90427 Mito_carr cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part amine transmembrane transporter activity;amino acid transmembrane transporter activity;binding;calcium ion binding;L-glutamate transmembrane transporter activity;organic acid transmembrane transporter activity;protein binding;transporter activity acidic amino acid transport;amino acid transport;anion transport;aspartate transport;cellular process;ion transport;L-glutamate transport;mitochondrial transport;organic anion transport;response to inorganic substance;response to metal ion;transport 17 17 13 31.3 31.3 24.8 74.761 3.0221E-252 197470000 108500000 88972000 4533 IPI:IPI00386271.4 Calcium-binding mitochondrial carrier protein Aralar1;Mitochondrial aspartate glutamate carrier 1;Solute carrier family 25 member 12 SLC25A12;ARALAR1 O75746 ENST00000263812 1 NaN 0.90336 0.23818 NaN 0.61773 0.28993 HARP;Helicase_C;SNF2_N cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;DNA binding;DNA helicase activity;DNA-dependent ATPase activity;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity chromatin organization;DNA metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent 3 3 3 4.2 4.2 4.2 105.94 4.341E-18 210730000 118330000 92400000 4534 IPI:IPI00386311.2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1;Sucrose nonfermenting protein 2-like 1;HepA-related protein SMARCAL1;HARP Q9NZC9 ENST00000357276;ENST00000358207;ENST00000392128 1 0.86788 1.6581 0.70658 1.1751 1.0367 0.98106 BRK;Bromodomain;Helicase_C;HSA;QLQ;SNF2_N cell part;chromatin remodeling complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex;SWI/SNF complex;SWI/SNF-type complex ATP binding;binding;catalytic activity;DNA binding;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;transcription coactivator activity;transcription cofactor activity chromatin organization;chromatin remodeling;negative regulation of transcription from RNA polymerase II promoter;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 14 2 2 8.8 2.1 2.1 181.28 4.9792E-79 8192100 4524900 3667100 4535 IPI:IPI00514648.1;IPI:IPI00386718.4 Probable global transcription activator SNF2L2;ATP-dependent helicase SMARCA2;SNF2-alpha;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 SMARCA2;BRM;SNF2A;SNF2L2 P51531-1;P51531;P51531-2 ENST00000349721;ENST00000357248;ENST00000382203 K11647 2 0.83467 1.6678 0.77049 1.0946 1.055 0.98661 ERO1 cell fraction;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;insoluble fraction;intracellular part;membrane;membrane fraction;membrane part;microsome;organelle membrane;organelle part;vesicular fraction binding;catalytic activity;electron carrier activity;nucleoside binding;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on sulfur group of donors;protein binding;purine nucleoside binding 'de novo' protein folding;generation of precursor metabolites and energy;metabolic process;protein folding;protein modification process;protein thiol-disulfide exchange;response to abiotic stimulus;response to temperature stimulus;transport Vibrio cholerae infection 17 17 16 41.7 41.7 39.3 54.392 1.043E-167 326860000 177810000 149050000 4536 IPI:IPI00386755.2 ERO1-like protein alpha;Oxidoreductin-1-L-alpha;Endoplasmic oxidoreductin-1-like protein ERO1L;UNQ434/PRO865 Q96HE7 ENST00000359133;ENST00000395686 K10950 1 0.59593 1.4695 0.55665 0.81179 0.95174 0.7406 Ndc1_Nup cell part;intracellular organelle part;intracellular part;macromolecular complex;membrane;membrane part;nuclear membrane;nuclear part;nuclear pore;organelle membrane;organelle part;pore complex;protein complex structural constituent of nuclear pore;structural molecule activity anatomical structure formation;cellular process;intracellular protein transport;nuclear pore organization;nucleus organization;organelle organization;protein complex assembly;protein transport;transport 7 7 7 12.9 12.9 12.9 76.304 5.5172E-87 91142000 53657000 37485000 4537 IPI:IPI00386760.2;IPI:IPI00746642.1;IPI:IPI00003455.3;IPI:IPI00074330.7 Nucleoporin NDC1;Transmembrane protein 48 TMEM48;NDC1 Q9BTX1-1;Q9BTX1;Q9BTX1-2;Q9BTX1-4;Q9BTX1-3 ENST00000234725;ENST00000360494;ENST00000371429 4 0.78162 1.2602 0.73756 1.0018 0.84136 0.91839 Hist_deacetyl cell part;chromatin remodeling complex;cytoplasm;histone deacetylase complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex catalytic activity;deacetylase activity;histone deacetylase activity;hydrolase activity;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides biosynthetic process;chromatin organization;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;regulation of transcription, DNA-dependent;transcription 2 2 2 2.6 2.6 2.6 108.94 9.441E-09 20773000 11286000 9486700 4538 IPI:IPI00909569.1;IPI:IPI00916348.1;IPI:IPI00916810.2;IPI:IPI00916470.1;IPI:IPI00743474.1;IPI:IPI00386808.4;IPI:IPI00917034.3;IPI:IPI00944518.1;IPI:IPI00306189.3;IPI:IPI00944634.1 Histone deacetylase 7;HD7a HDAC7;HDAC7A Q8WUI4-8;Q8WUI4;Q8WUI4-5;Q8WUI4-6;Q8WUI4-7;Q8WUI4-1;Q8WUI4-4;Q8WUI4-3;Q8WUI4-10;Q8WUI4-2;Q8WUI4-9 ENST00000080059;ENST00000310824;ENST00000354334;ENST00000380610 10 NaN 2.307 NaN NaN 1.5324 NaN GoLoco;Rap_GAP cytoplasmic part;Golgi apparatus part;Golgi membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane;membrane-bounded organelle;nucleus;organelle;organelle membrane;organelle part enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity cell communication;cellular process;regulation of biological process;regulation of cell communication;regulation of cellular process;regulation of signal transduction;regulation of small GTPase mediated signal transduction;signal transduction 2 2 2 3.1 3.1 3.1 75.186 6.9036E-09 5089300 2399000 2690300 4540 IPI:IPI00386930.6;IPI:IPI00843926.4 Rap1 GTPase-activating protein 1 RAP1GAP;KIAA0474;RAP1GA1 P47736-2;P47736;P47736-1 ENST00000317967;ENST00000359708;ENST00000374761;ENST00000374765 2 0.81589 1.4922 0.81999 1.0596 0.96872 1.0606 A_deamin;dsrm;z-alpha cell part;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part adenosine deaminase activity;binding;catalytic activity;DNA binding;double-stranded RNA adenosine deaminase activity;double-stranded RNA binding;hydrolase activity;nucleic acid binding;RNA binding;zinc ion binding cellular process;metabolic process;mRNA processing;negative regulation of metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA modification;RNA processing Atrazine degradation 29 29 4 26.2 26.2 3.3 140.74 0 1281900000 670640000 611230000 4543 IPI:IPI00394668.2;IPI:IPI00394665.4;IPI:IPI00760588.2 Double-stranded RNA-specific adenosine deaminase;136 kDa double-stranded RNA-binding protein;P136;K88DSRBP;Interferon-inducible protein 4 ADAR;ADAR1;DSRAD;G1P1;IFI4 P55265-4;P55265;P55265-1;P55265-5 ENST00000292205;ENST00000368474;ENST00000392506 K01500 3 0.69137 1.556 0.78644 0.9346 0.98652 1.0556 cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part biosynthetic process;metabolic process;multicellular organismal development;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 10 10 10 26.7 26.7 26.7 58.499 8.6633E-50 166710000 88142000 78564000 4544 IPI:IPI00394679.3;IPI:IPI00643383.3 Negative elongation factor A;Wolf-Hirschhorn syndrome candidate 2 protein WHSC2;NELFA;P/OKcl.15 Q9H3P2-7;Q9H3P2;Q9H3P2-1 ENST00000333877;ENST00000382882 2 0.63234 1.405 0.67653 0.86593 0.8028 0.89032 Oxysterol_BP;PH cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle biosynthetic process;cellular biosynthetic process;cellular lipid metabolic process;cellular metabolic process;cellular process;lipid metabolic process;lipid transport;metabolic process;primary metabolic process;steroid metabolic process;transport 15 15 13 25.5 25.5 23.2 99.713 1.4393E-136 188880000 102550000 86329000 4545 IPI:IPI00394737.1;IPI:IPI00163644.2 Oxysterol-binding protein-related protein 8 OSBPL8;KIAA1451;ORP8;OSBP10 Q9BZF1-2;Q9BZF1;Q9BZF1-1 ENST00000261183;ENST00000393250 2 0.43747 1.9555 NaN 0.64203 1.2986 NaN HD catalytic activity 3 3 3 22.9 22.9 22.9 20.329 0.00077199 10604000 7262400 3341400 4547 IPI:IPI00789618.2;IPI:IPI00394782.5 HD domain-containing protein 3 HDDC3 Q8N4P3-1;Q8N4P3;Q8N4P3-2 ENST00000330334;ENST00000394272 2 0.75988 1.4034 0.7437 0.96234 0.93118 0.95202 tRNA_SAD;tRNA-synt_2c cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part alanine-tRNA ligase activity;aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-oxygen bonds;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding alanyl-tRNA aminoacylation;cellular amino acid and derivative metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;tRNA aminoacylation for protein translation;tRNA metabolic process 13 13 13 15.7 15.7 15.7 107.34 1.7823E-112 208020000 106990000 101030000 4548 IPI:IPI00394788.4 Probable alanyl-tRNA synthetase, mitochondrial;Alanine--tRNA ligase;Alanyl-tRNA synthetase-like AARS2;AARSL;KIAA1270 Q5JTZ9 ENST00000244571 1 0.80195 1.7063 0.95069 1.0802 1.101 1.2478 ApoO extracellular region 4 4 4 14.6 14.6 14.6 29.159 1.5085E-31 58870000 31660000 27210000 4550 IPI:IPI00394809.1 Apolipoprotein O-like;Protein FAM121A APOOL;CXorf33;FAM121A;UNQ8193/PRO23204 Q6UXV4 ENST00000373169;ENST00000373173 1 NaN 1.6208 0.65034 NaN 0.97559 0.8095 Lectin_C cell part;integral to membrane;intrinsic to membrane;membrane part binding;carbohydrate binding;sugar binding 2 2 2 5.4 5.4 5.4 42.823 0.0002082 3659000 1052400 2606600 4551 IPI:IPI00394851.2;IPI:IPI00719758.2 Killer cell lectin-like receptor subfamily G member 2;C-type lectin domain family 15 member B KLRG2;CLEC15B A4D1S0-1;A4D1S0;A4D1S0-2 ENST00000340940;ENST00000393039 2 0.46634 0.88859 0.50527 0.62893 0.53976 0.67524 CDC27 cell part;chromosomal part;delta DNA polymerase complex;DNA polymerase complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear chromosome part;nuclear part;nucleoplasm;organelle part;protein complex binding;catalytic activity;DNA binding;DNA polymerase activity;DNA-directed DNA polymerase activity;nucleic acid binding;nucleotidyltransferase activity;protein binding;transferase activity;transferase activity, transferring phosphorus-containing groups DNA metabolic process;DNA repair;DNA replication;DNA synthesis during DNA repair;mismatch repair;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleotide-excision repair, DNA gap filling DNA replication;Nucleotide excision repair 6 6 6 15.2 15.2 15.2 51.4 1.5615E-46 149050000 88432000 60616000 4552 IPI:IPI00394926.1 DNA polymerase delta subunit 3;DNA polymerase delta subunit p66 POLD3;KIAA0039 Q15054 ENST00000263681 K03504 1 0.61364 NaN NaN 0.767 NaN NaN KASH cell part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;nuclear membrane;nuclear outer membrane;nuclear part;organelle membrane;organelle outer membrane;organelle part;outer membrane actin binding;binding;cytoskeletal protein binding;protein binding 2 2 2 2.1 2.1 2.1 112.22 1.919E-13 5232200 2777600 2454600 4554 IPI:IPI00394994.2;IPI:IPI00829842.1;IPI:IPI00830100.1 Nesprin-3 C14orf49 Q6ZMZ3-1;Q6ZMZ3;Q6ZMZ3-2;Q6ZMZ3-3 ENST00000334258 3 0.85003 1.4342 0.83613 1.0329 1.0151 1.0673 La binding;nucleic acid binding;RNA binding 10 10 9 18.1 18.1 17.3 81.243 2.205E-151 259630000 141960000 117670000 4555 IPI:IPI00797384.2;IPI:IPI00395347.3;IPI:IPI00418689.4;IPI:IPI00043638.1 La-related protein 4;La ribonucleoprotein domain family member 4 LARP4;PP13296 Q71RC2-4;Q71RC2;Q71RC2-1;Q71RC2-3;Q71RC2-2 ENST00000293618;ENST00000341915;ENST00000398473 4 0.58814 1.0827 0.62146 0.76726 0.7194 0.81716 PCI binding;protein binding 18 18 18 52.1 52.1 52.1 46.029 0 536550000 293860000 242700000 4556 IPI:IPI00395420.5;IPI:IPI00100313.2;IPI:IPI00478550.4;IPI:IPI00072541.4 PCI domain-containing protein 2;CSN12-like protein PCID2;HT004 Q5JVF3-1;Q5JVF3;Q5JVF3-4;Q5JVF3-2;Q5JVF3-3 ENST00000246505;ENST00000337344;ENST00000375477;ENST00000375479 4 0.6529 1.6019 0.76492 0.92538 1.0414 1.022 DUF1781 3 3 3 2.5 2.5 2.5 179.34 6.9533E-15 7956100 4530000 3426100 4557 IPI:IPI00884928.1;IPI:IPI00395444.7;IPI:IPI00647751.2 Calmodulin-regulated spectrin-associated protein 1 CAMSAP1 Q5T5Y3-3;Q5T5Y3;Q5T5Y3-1;Q5T5Y3-2 ENST00000312405;ENST00000389533;ENST00000409386 3 0.81079 1.6317 0.65123 1.0331 1.081 0.84507 Snf7 cell part;cytoplasmic part;endosomal part;ESCRT III complex;intracellular organelle part;intracellular part;macromolecular complex;membrane part;organelle part;protein complex protein transporter activity;substrate-specific transporter activity;transporter activity cellular process;endosome transport;establishment of localization;establishment of protein localization;intracellular transport;late endosome to vacuole transport;protein transport;transport;vacuolar transport;vesicle-mediated transport 9 9 9 23 23 23 50.91 2.0351E-30 160930000 88232000 72699000 4558 IPI:IPI00395463.3 Charged multivesicular body protein 7;Chromatin-modifying protein 7 CHMP7 Q8WUX9 ENST00000313219;ENST00000397677 1 0.42024 0.64455 NaN 0.54551 0.44691 NaN SAM_1 cell part;cytoplasm;extracellular region;intracellular part 2 2 2 5.2 5.2 5.2 56.051 3.0489E-20 1747200 1020500 726770 4559 IPI:IPI00395474.1 Atherin;Sterile alpha motif domain-containing protein 1 SAMD1 Q6SPF0 ENST00000269724;ENST00000397471 1 0.43404 NaN NaN 0.58092 NaN NaN binding 4 4 4 5.7 5.7 5.7 94.5 3.2812E-42 6742500 3743100 2999400 4560 IPI:IPI00395476.3;IPI:IPI00887756.1 Putative protein arginine N-methyltransferase 10 PRMT10 Q6P2P2-1;Q6P2P2 ENST00000322396 2 1.0297 1.918 0.99172 1.4064 1.2476 1.3347 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 9 9 9 28.2 28.2 28.2 41.29 3.8654E-187 414180000 207810000 206380000 4561 IPI:IPI00395568.1;IPI:IPI00397700.5 PHD finger protein 6;PHD-like zinc finger protein PHF6;KIAA1823 Q8IWS0-1;Q8IWS0;Q8IWS0-2 ENST00000332070;ENST00000370800;ENST00000370803;ENST00000394292 2 0.80923 1.563 0.79233 1.0412 1.0387 1.0376 RGS-like;RhoGEF cell part;cytoplasmic part;cytosol;intracellular part;membrane;plasma membrane binding;enzyme activator activity;GTPase activator activity;guanyl-nucleotide exchange factor activity;protein binding;Ras guanyl-nucleotide exchange factor activity;Rho guanyl-nucleotide exchange factor activity;small GTPase regulator activity cell communication;cell proliferation;cellular process;intracellular signaling cascade;Ras protein signal transduction;regulation of signal transduction;Rho protein signal transduction;signal transduction;small GTPase mediated signal transduction Vascular smooth muscle contraction 32 32 32 33.5 33.5 33.5 104.06 0 1250400000 641790000 608650000 4562 IPI:IPI00395605.4;IPI:IPI00647786.1;IPI:IPI00339379.3;IPI:REV_IPI00289204.3 Rho guanine nucleotide exchange factor 1;115 kDa guanine nucleotide exchange factor;p115-RhoGEF;p115RhoGEF;Sub1.5 ARHGEF1 Q92888-3;Q92888;Q92888-1;Q92888-2 ENST00000337665;ENST00000347545;ENST00000354532;ENST00000378152 K12330 4 1.2816 2.383 1.2776 1.7129 1.4774 1.711 CS;SGS;Siah-Interact_N cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 20 20 20 59.6 59.6 59.6 26.21 0 5887500000 2850400000 3037100000 4563 IPI:IPI00395627.3;IPI:IPI00410678.1 Calcyclin-binding protein;Siah-interacting protein;S100A6-binding protein CACYBP;S100A6BP;SIP;PNAS-107 Q9HB71-1;Q9HB71 ENST00000367679 2 1.0662 NaN 1.2477 1.4875 NaN 1.5756 Pkinase cAMP-dependent protein kinase complex;cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;protein complex catalytic activity;cyclic nucleotide-dependent protein kinase activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding cell communication;cell surface receptor linked signal transduction;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;signal transduction Apoptosis;Calcium signaling pathway;Chemokine signaling pathway;Gap junction;GnRH signaling pathway;Hedgehog signaling pathway;Insulin signaling pathway;Long-term potentiation;MAPK signaling pathway;Melanogenesis;Olfactory transduction;Progesterone-mediated oocyte maturation;Taste transduction;Vascular smooth muscle contraction;Vibrio cholerae infection;Wnt signaling pathway 14 5 5 38.7 20.8 20.8 40.622 1.3654E-104 10821000 5342700 5478100 4564 IPI:IPI00395654.7;IPI:IPI00376119.1;IPI:IPI00645788.2;IPI:IPI00738231.1;IPI:IPI00737155.1;IPI:IPI00739595.1;IPI:IPI00739094.1;IPI:IPI00414365.1 cAMP-dependent protein kinase catalytic subunit beta PRKACB P22694-1;P22694;P22694-2;P22694-6;P22694-7;P22694-5;P22694-3;P22694-4;P22694-8 ENST00000370681;ENST00000370685;ENST00000370689;ENST00000394838;ENST00000394839 K04345 8 NaN 1.591 0.81502 NaN 0.99514 1.1736 Ank;PID;SAM_1 cell part;cytoplasm;intracellular part binding;protein binding 4 4 4 6 6 6 123.11 5.6642E-35 44669000 25394000 19275000 4565 IPI:IPI00395663.5 Ankyrin repeat and SAM domain-containing protein 1A;Odin ANKS1A;ANKS1;KIAA0229 Q92625 ENST00000360359 1 0.8912 2.141 0.90765 1.1874 1.3414 1.2055 UDPGP cell part;cytoplasmic part;cytosol;intracellular part binding;catalytic activity;nucleotidyltransferase activity;protein binding;transferase activity;transferase activity, transferring phosphorus-containing groups;UTP:glucose-1-phosphate uridylyltransferase activity alcohol metabolic process;carbohydrate metabolic process;glucose metabolic process;monosaccharide metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;phosphorus metabolic process;UDP-glucose metabolic process Galactose metabolism;Nucleotide sugars metabolism;Pentose and glucuronate interconversions;Starch and sucrose metabolism 13 13 13 33.9 33.9 33.9 56.94 0 751630000 414190000 337430000 4566 IPI:IPI00329331.6;IPI:IPI00395676.1 UTP--glucose-1-phosphate uridylyltransferase;UDP-glucose pyrophosphorylase UGP2;UGP1 Q16851-1;Q16851;Q16851-2 ENST00000337130;ENST00000394417;ENST00000394418 K00963 2 0.94388 1.7301 0.9874 1.1908 1.211 1.2504 Xpo1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;molecular transducer activity;protein binding;receptor activity;signal transducer activity establishment of localization;establishment of protein localization;protein transport;transport 21 21 21 29.9 29.9 29.9 108.92 0 643640000 324370000 319270000 4567 IPI:IPI00872398.2;IPI:IPI00395694.1;IPI:IPI00455127.2 Transportin-3;Transportin-SR;Importin-12 TNPO3;IPO12 Q9Y5L0-1;Q9Y5L0;Q9Y5L0-2;Q9Y5L0-3 ENST00000265388;ENST00000359305;ENST00000393245 3 0.76344 1.1925 0.70715 1.0086 0.79471 0.98622 WD40 binding;protein binding chromatin organization;DNA metabolic process;DNA replication;multicellular organismal development;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;transcription 13 8 8 41.2 32.5 32.5 47.82 3.738E-272 886890000 461380000 425510000 4568 IPI:IPI00395865.4 Histone-binding protein RBBP7;Retinoblastoma-binding protein 7;Retinoblastoma-binding protein p46;Histone acetyltransferase type B subunit 2;Nucleosome-remodeling factor subunit RBAP46 RBBP7;RBAP46 Q16576 ENST00000330735;ENST00000380084 K11659 1 0.68416 1.4574 0.71474 0.90679 0.94741 0.94636 Thioredoxin cell fraction;endoplasmic reticulum membrane;insoluble fraction;integral to membrane;intracellular organelle;intrinsic to membrane;membrane;membrane fraction;membrane-bounded organelle;nucleus;organelle;organelle membrane arsenate reductase (thioredoxin) activity;arsenate reductase activity;catalytic activity;disulfide oxidoreductase activity;oxidoreductase activity;oxidoreductase activity, acting on sulfur group of donors cell activation;DNA metabolic process;DNA replication;generation of precursor metabolites and energy;immune system process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent 10 10 10 29.3 29.3 29.3 31.791 4.8084E-77 739050000 359460000 379580000 4569 IPI:IPI00395887.4 Thioredoxin-related transmembrane protein 1;Thioredoxin domain-containing protein 1;Transmembrane Trx-related protein TMX1;TMX;TXNDC;TXNDC1;PSEC0085;UNQ235/PRO268 Q9H3N1 ENST00000267434 1 1.2305 1.9445 0.79275 1.6994 1.2304 0.999 DUF1356 cell part;integral to membrane;intrinsic to membrane;membrane part 4 4 4 14.2 14.2 14.2 31.127 2.2788E-06 62397000 34021000 28376000 4570 IPI:IPI00395903.1 Transmembrane protein 106B TMEM106B Q9NUM4 ENST00000336176;ENST00000396667;ENST00000396668 1 0.68366 1.265 0.95192 0.89864 0.83281 1.2484 Ribosomal_L32e binding;protein binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 4 4 4 32.6 32.6 32.6 15.86 1.493E-95 1280800000 663950000 616810000 4571 IPI:IPI00395998.5 60S ribosomal protein L32 RPL32;PP9932 P62910 ENST00000273223;ENST00000396953;ENST00000396957 K02912 1 NaN 1.8482 1.0077 NaN 1.2081 1.4871 SPT2 4 4 4 8.5 8.5 8.5 75.545 4.7089E-07 14373000 7285300 7087800 4572 IPI:IPI00396008.3;IPI:IPI00879460.1;IPI:IPI00878933.1 Protein SPT2 homolog;SPT2 domain-containing protein 1;Protein KU002155 SPTY2D1 Q68D10-1;Q68D10;Q68D10-2 ENST00000333429;ENST00000336349 3 0.73811 1.5019 0.60664 0.99492 1.06 0.81606 PID;TBC cell part;intracellular enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity;Rab GTPase activator activity;Ras GTPase activator activity;small GTPase regulator activity biological regulation;regulation of catalytic activity;regulation of GTPase activity;regulation of hydrolase activity;regulation of molecular function;regulation of Rab GTPase activity;regulation of Ras GTPase activity 5 3 3 4.8 3 3 94.001 7.9744E-09 14128000 8212700 5915000 4573 IPI:IPI00477388.5;IPI:IPI00396010.3;IPI:IPI00902948.1;IPI:IPI00418300.1 RAB GTPase-activating protein 1-like RABGAP1L;HHL;KIAA0471 Q5R372-3;Q5R372;Q5R372-1;Q5R372-4;Q5R372-2 ENST00000251507;ENST00000367692;ENST00000407735 4 0.2909 0.66317 0.30404 0.3687 0.41377 0.40549 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding cell cycle process;cell division;cellular component organization;cellular process;chromosome condensation;chromosome organization;DNA packaging;mitotic chromosome condensation;organelle organization 9 9 9 7.6 7.6 7.6 132.19 3.1966E-37 37167000 22760000 14407000 4574 IPI:IPI00396058.2;IPI:IPI00797030.1 Condensin-2 complex subunit G2;Chromosome-associated protein G2;Non-SMC condensin II complex subunit G2;Leucine zipper protein 5 NCAPG2;LUZP5 Q86XI2-2;Q86XI2;Q86XI2-1 ENST00000356309;ENST00000409339;ENST00000409423 K11492 2 0.71213 1.3183 0.69414 0.94319 0.86252 0.9435 UIM BRCA1-A complex;cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex binding;histone binding;K63-linked polyubiquitin binding;polyubiquitin binding;protein binding;small conjugating protein binding;ubiquitin binding cell cycle checkpoint;DNA damage checkpoint;DNA metabolic process;DNA repair;double-strand break repair;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of DNA repair;regulation of transcription, DNA-dependent;transcription 2 2 2 3.9 3.9 3.9 79.727 2.7316E-09 11805000 6400000 5404800 4575 IPI:IPI00396071.3;IPI:IPI00552059.2;IPI:IPI00872390.2 BRCA1-A complex subunit RAP80;Receptor-associated protein 80;Ubiquitin interaction motif-containing protein 1;Retinoid X receptor-interacting protein 110 UIMC1;RAP80;RXRIP110 Q96RL1-1;Q96RL1;Q96RL1-3;Q96RL1-2 ENST00000274827;ENST00000323774;ENST00000377219;ENST00000377227 3 0.74722 1.5723 0.72415 1.0168 0.92183 0.90623 BRAP2;zf-C3HC4;zf-UBP cell part;cytoplasm;intracellular part acid-amino acid ligase activity;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;protein binding;small conjugating protein ligase activity;ubiquitin-protein ligase activity;zinc ion binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;negative regulation of cell communication;negative regulation of signal transduction;proteolysis;regulation of cell communication;regulation of signal transduction 6 6 6 13.9 13.9 13.9 67.29 3.3399E-33 17741000 9710100 8030700 4576 IPI:IPI00396089.1 BRCA1-associated protein;BRAP2;Impedes mitogenic signal propagation;RING finger protein 52;Renal carcinoma antigen NY-REN-63 BRAP;RNF52 Q7Z569 ENST00000327551 1 0.36219 1.0994 0.63835 0.51239 0.77301 0.80311 Cpn60_TCP1;DEP;FYVE;PIP5K cell part;cytoplasmic part;early endosome membrane;endosomal part;endosome membrane;intracellular organelle part;intracellular part;membrane;membrane part;membrane raft;organelle membrane;organelle part ATP binding;binding;catalytic activity;inositol or phosphatidylinositol kinase activity;kinase activity;lipid kinase activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;zinc ion binding cell communication;cellular process;glycerophospholipid metabolic process;intracellular signaling cascade;lipid metabolic process;metabolic process;phospholipid metabolic process;protein localization;signal transduction;transport Inositol phosphate metabolism;Phosphatidylinositol signaling system;Regulation of actin cytoskeleton 11 11 11 6.1 6.1 6.1 237.11 4.5411E-35 38381000 22579000 15803000 4579 IPI:IPI00396145.1 FYVE finger-containing phosphoinositide kinase;PIKfyve;1-phosphatidylinositol-4-phosphate 5-kinase;Phosphatidylinositol-3-phosphate 5-kinase type III;p235 PIKFYVE;KIAA0981;PIP5K3 Q9Y2I7 ENST00000264380 K00889 1 0.79881 1.4818 0.746 1.0873 0.93077 1.022 Tubulin-binding cell part;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;microtubule;microtubule associated complex;organelle part;protein complex binding;protein binding;structural molecule activity negative regulation of macromolecule metabolic process;negative regulation of metabolic process;negative regulation of microtubule depolymerization;negative regulation of organelle organization;regulation of metabolic process 15 15 15 18.8 18.8 18.8 121 1.4908E-194 898190000 500780000 397420000 4580 IPI:IPI00396171.4;IPI:IPI00888475.2;IPI:IPI00220113.1;IPI:IPI00927819.2;IPI:IPI00411375.3 Microtubule-associated protein 4 MAP4 P27816-1;P27816;P27816-6;P27816-2 ENST00000264724;ENST00000320796;ENST00000360240;ENST00000395734;ENST00000403918 K10431 5 0.89681 1.6544 0.88095 1.2219 1.0425 1.2174 DUF814 9 9 9 42.3 42.3 42.3 24.479 4.1283E-81 187270000 98882000 88390000 4581 IPI:IPI00396174.4 Coiled-coil domain-containing protein 25 CCDC25 Q86WR0 ENST00000356537 1 0.72156 1.6222 0.63079 0.97214 1.0745 0.8572 Mak10 cell part;cytoplasm;intracellular part binding;protein binding cell proliferation;cellular process;muscle cell proliferation;smooth muscle cell proliferation 10 10 10 15.3 15.3 15.3 83.638 2.9634E-26 541310000 296670000 244640000 4582 IPI:IPI00396185.2 Protein MAK10 homolog;Embryonic growth-associated protein homolog MAK10;EGAP Q5VZE5 ENST00000361671 1 0.42918 0.94971 0.46647 0.56843 0.63112 0.56831 HEAT cell part;cytoskeletal part;intracellular organelle part;intracellular part;microtubule;organelle part binding;chaperone binding;protein binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 25 25 25 26.8 26.8 26.8 132.53 0 464660000 279480000 185170000 4583 IPI:IPI00396203.6;IPI:IPI00030774.2;IPI:IPI00386607.2;IPI:IPI00941229.1;IPI:IPI00719188.1 Tubulin-specific chaperone D;Tubulin-folding cofactor D;Beta-tubulin cofactor D;SSD-1 TBCD;KIAA0988;SSD1;TFCD;PP1096 Q9BTW9-1;Q9BTW9;Q9BTW9-4;Q9BTW9-5 ENST00000334614;ENST00000336211;ENST00000355528;ENST00000397466 5 1.0846 1.6909 0.92155 1.344 1.0865 1.1982 Pkinase clathrin-coated vesicle;coated vesicle;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;endosome membrane;Golgi apparatus;intracellular organelle;membrane;membrane-bounded organelle;membrane-bounded vesicle;organelle;organelle membrane;vesicle ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups cellular biopolymer metabolic process;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process 8 8 8 9.9 9.9 9.9 103.71 2.3433E-38 40972000 21436000 19536000 4584 IPI:IPI00396218.2 SCY1-like protein 2;Coated vesicle-associated kinase of 104 kDa SCYL2;CVAK104;KIAA1360 Q6P3W7 ENST00000360820 1 0.69416 1.5928 0.79602 0.88855 1.0125 1.008 Aminotran_4 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle branched-chain-amino-acid transaminase activity;catalytic activity;transaminase activity;transferase activity;transferase activity, transferring nitrogenous groups biosynthetic process;cellular amino acid and derivative metabolic process;cellular amino acid biosynthetic process;cellular amino acid metabolic process;metabolic process;nitrogen compound metabolic process;organic acid metabolic process Pantothenate and CoA biosynthesis;Valine, leucine and isoleucine biosynthesis;Valine, leucine and isoleucine degradation 10 10 10 29.3 29.3 29.3 44.287 1.4349E-191 337560000 182260000 155300000 4585 IPI:IPI00396258.3;IPI:IPI00181135.4 Branched-chain-amino-acid aminotransferase, mitochondrial;Placental protein 18 BCAT2;BCATM;BCT2;ECA40 O15382-1;O15382;O15382-2 ENST00000316273;ENST00000402551 K00826 2 0.50854 0.97551 NaN 0.71495 0.63345 NaN DUF2348 2 2 2 9.4 9.4 9.4 29.793 0.001984 4507200 2451500 2055700 4586 IPI:IPI00872492.1;IPI:IPI00396268.3 UPF0405 protein C3orf75;Protein TMEM103;Angiotonin-transactivated protein 1 C3orf75;ATP1;TMEM103 Q0PNE2-1;Q0PNE2;Q0PNE2-2 ENST00000296149;ENST00000327410 2 0.95221 1.9198 0.93515 1.2633 1.2128 1.178 HEAT centrosomal corona;condensed chromosome kinetochore;cortical cytoskeleton;cortical microtubule cytoskeleton;cytoplasmic microtubule;cytoskeleton;Golgi apparatus;kinetochore;kinetochore microtubule;macromolecular complex;microtubule;spindle microtubule binding;cytoskeletal protein binding;kinetochore binding;microtubule binding;microtubule plus-end binding;protein binding;tubulin binding cytoskeleton organization;microtubule bundle formation;microtubule cytoskeleton organization;microtubule-based process;mitosis;negative regulation of microtubule depolymerization;nuclear division;organelle organization 15 10 10 11.4 8.5 8.5 169.45 1.4572E-221 82705000 44267000 38438000 4587 IPI:IPI00396279.3;IPI:IPI00744551.2;IPI:IPI00828013.3 CLIP-associating protein 1;Cytoplasmic linker-associated protein 1;Multiple asters homolog 1 CLASP1;KIAA0622;MAST1 Q7Z460-1;Q7Z460;Q7Z460-3;Q7Z460-2 ENST00000263710;ENST00000397587 3 0.63047 1.638 0.65149 0.84062 1.0526 0.90532 TPR_1 binding;protein binding 10 10 10 20.2 20.2 20.2 79.377 3.4577E-162 102500000 57403000 45102000 4588 IPI:IPI00396314.5;IPI:IPI00794753.3;IPI:IPI00790411.2;IPI:IPI00878368.1;IPI:IPI00791933.1 CCR4-NOT transcription complex subunit 10 CNOT10 Q9H9A5-3;Q9H9A5;Q9H9A5-4;Q9H9A5-1;Q9H9A5-2 ENST00000328834;ENST00000331889 5 0.62542 1.3059 0.67217 0.81501 0.85559 0.88976 LRR_1 cell fraction;endoplasmic reticulum membrane;insoluble fraction;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane fraction;microsome;mitochondrial nucleoid;nucleoid;organelle membrane;organelle part;vesicular fraction binding;protein binding 9 9 9 30.3 30.3 30.3 34.93 1.7149E-153 1164200000 626260000 537910000 4589 IPI:IPI00396321.1 Leucine-rich repeat-containing protein 59 LRRC59;PRO1855 Q96AG4 ENST00000225972 1 0.86506 1.22 0.7094 1.1429 0.81786 0.8593 Brix cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;protein binding 7 7 7 25.5 25.5 25.5 35.582 2.5288E-34 93988000 48514000 45475000 4590 IPI:IPI00396329.1 Brix domain-containing protein 1 BXDC1 Q9H7B2 ENST00000368864 1 0.7088 1.3509 0.69179 0.94644 0.89764 0.90069 eIF2A;RRM_1 cell part;cytoplasmic part;cytosol;eukaryotic translation initiation factor 3 complex;intracellular part;macromolecular complex;protein complex binding;nucleic acid binding;nucleotide binding;protein binding;protein complex scaffold;RNA binding;structural molecule activity;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity cellular process;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of translation;regulation of translational initiation;translational initiation 36 36 36 44.8 44.8 44.8 99.028 0 5436200000 3580100000 1856000000 4591 IPI:IPI00719752.2;IPI:IPI00396370.6 Eukaryotic translation initiation factor 3 subunit B;Eukaryotic translation initiation factor 3 subunit 9;eIF-3-eta;eIF3 p116;eIF3 p110;Prt1 homolog EIF3B;EIF3S9 P55884-2;P55884;P55884-1 ENST00000314800;ENST00000360876;ENST00000397011 K03253 2 0.81786 1.5839 0.83851 1.0826 1.0122 1.1084 RRM_1 cell part;cytoplasm;heterogeneous nuclear ribonucleoprotein complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;ribonucleoprotein complex;spliceosomal complex binding;DNA binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding;sequence-specific DNA binding;single-stranded DNA binding;single-stranded telomeric DNA binding;structure-specific DNA binding;telomeric DNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 29 29 2 70 70 2.8 37.429 0 20954000000 10750000000 10204000000 4592 IPI:IPI00396378.3 Heterogeneous nuclear ribonucleoproteins A2/B1 HNRNPA2B1;HNRPA2B1 P22626-1;P22626 ENST00000354667;ENST00000356674;ENST00000360787 1 0.77781 1.3889 0.7202 0.9736 0.9126 0.92571 MMR_HSR1 cell part;extracellular region part;extracellular space;intracellular binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding;structural molecule activity adaptive immune response;immune effector process;immune system process;leukocyte mediated immunity;lymphocyte mediated immunity;T cell mediated immunity 14 14 14 27.8 27.8 27.8 68.66 2.6178E-135 428580000 231560000 197010000 4593 IPI:IPI00396387.3;IPI:IPI00479495.6 Guanine nucleotide-binding protein-like 1;GTP-binding protein HSR1 GNL1;HSR1 P36915-1;P36915;P36915-2 ENST00000376621;ENST00000383450;ENST00000383596 2 0.72178 1.5232 0.75043 0.93327 0.96905 0.9236 zf-C3HC4;zf-CCCH cell part;intracellular binding;cation binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transition metal ion binding;zinc ion binding 5 5 5 9.9 9.9 9.9 46.94 1.6523E-09 122560000 63215000 59347000 4594 IPI:IPI00396406.6 Makorin-2;RING finger protein 62 MKRN2;RNF62;HSPC070 Q9H000 ENST00000170447 1 0.59453 1.2046 0.59826 0.80582 0.79424 0.78513 DUF1605;HA2;Helicase_C cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex;U12-type spliceosomal complex ATP binding;ATP-dependent helicase activity;binding;catalytic activity;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity;RNA helicase activity cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 42 42 41 48.1 48.1 46.9 90.932 0 5061500000 2813600000 2247900000 4595 IPI:IPI00396435.3 Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15;DEAH box protein 15;ATP-dependent RNA helicase #46 DHX15;DBP1;DDX15 O43143 ENST00000336812 1 0.65466 1.4491 0.65103 0.89201 0.93935 0.88449 GTP_EFTU;GTP_EFTU_D2;GTP_EFTU_D3 cell part;cytoplasm;cytoplasmic part;cytosol;eukaryotic translation elongation factor 1 complex;intracellular part;macromolecular complex;protein complex binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;nucleic acid binding;nucleotide binding;protein binding;pyrophosphatase activity;translation elongation factor activity;translation factor activity, nucleic acid binding biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation 36 36 21 77.5 77.5 45.9 50.14 0 39628000000 21663000000 17965000000 4596 IPI:IPI00396485.3;IPI:IPI00472724.1 Elongation factor 1-alpha 1;eEF1A-1;Elongation factor Tu;Leukocyte receptor cluster member 7;Putative elongation factor 1-alpha-like 3;eEF1A-like 3 EEF1A1;EEF1A;EF1A;LENG7;EEF1AL3 P68104;Q5VTE0 ENST00000309268;ENST00000316292;ENST00000331523 K03231 2 1.0126 1.8015 0.80026 1.2961 1.1378 1.0641 Sina cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle acid-amino acid ligase activity;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;protein binding;protein C-terminus binding;ubiquitin-protein ligase activity;zinc ion binding apoptosis;axon guidance;catabolic process;cell cycle;cell death;cell motion;gamete generation;macromolecule catabolic process;metabolic process;protein modification process;proteolysis;spermatogenesis;ubiquitin-dependent protein catabolic process p53 signaling pathway;Ubiquitin mediated proteolysis;Wnt signaling pathway 3 3 3 10.2 10.2 10.2 34.628 0.00028846 41213000 22162000 19051000 4597 IPI:IPI00328242.1;IPI:IPI00396517.3;IPI:IPI00872574.1;IPI:IPI00305283.1 E3 ubiquitin-protein ligase SIAH1;Seven in absentia homolog 1;Siah-1a SIAH1;HUMSIAH Q8IUQ4-2;Q8IUQ4;Q8IUQ4-1;Q8IUQ4-3 ENST00000356721;ENST00000359996;ENST00000380006;ENST00000394725 K04506 4 NaN 1.7485 NaN NaN 1.1456 NaN KLRAQ;TTKRSYEDQ 2 2 2 4 4 4 88.313 2.6927E-07 1064500 594680 469800 4598 IPI:IPI00396527.4;IPI:IPI00747521.3;IPI:IPI00845272.1;IPI:IPI00845285.2 KLRAQ motif-containing protein 1;Coiled-coil domain-containing protein 128 KLRAQ1;CCDC128 Q6ZMI0-1;Q6ZMI0;Q6ZMI0-2;Q6ZMI0-3;Q6ZMI0-4 ENST00000281394;ENST00000294952 4 0.55392 0.95192 0.5149 0.7316 0.66829 0.68642 Lactamase_B cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;cation binding;endonuclease activity;hydrolase activity;hydrolase activity, acting on ester bonds;ion binding;metal ion binding;nuclease activity;protein binding;transition metal ion binding;zinc ion binding cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;tRNA metabolic process;tRNA processing 23 23 23 37.8 37.8 37.8 92.218 1.8657E-215 369500000 200900000 168600000 4599 IPI:IPI00396627.1;IPI:IPI00398822.1;IPI:IPI00398823.1 Zinc phosphodiesterase ELAC protein 2;Ribonuclease Z 2;tRNase Z 2;tRNA 3 endonuclease 2;ElaC homolog protein 2;Heredity prostate cancer protein 2 ELAC2;HPC2 Q9BQ52-1;Q9BQ52;Q9BQ52-2 ENST00000338034 K00784 3 0.87775 1.9353 0.83634 1.1592 1.2069 1.114 Pkinase cAMP-dependent protein kinase complex;cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;protein complex binding;cAMP-dependent protein kinase activity;catalytic activity;cyclic nucleotide-dependent protein kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding cell communication;cellular process;hormone-mediated signaling;intracellular signaling cascade;protein kinase cascade;response to endogenous stimulus;response to hormone stimulus;response to organic substance;signal transduction Apoptosis;Calcium signaling pathway;Chemokine signaling pathway;Gap junction;GnRH signaling pathway;Hedgehog signaling pathway;Insulin signaling pathway;Long-term potentiation;MAPK signaling pathway;Melanogenesis;Olfactory transduction;Progesterone-mediated oocyte maturation;Taste transduction;Vascular smooth muscle contraction;Vibrio cholerae infection;Wnt signaling pathway 15 15 6 34.2 34.2 16.2 40.589 4.1389E-113 546580000 297020000 249550000 4600 IPI:IPI00396630.3;IPI:IPI00217960.1;IPI:IPI00219592.3;IPI:REV_IPI00029144.1 cAMP-dependent protein kinase catalytic subunit alpha PRKACA;PKACA P17612-1;P17612;P17612-2 ENST00000308677;ENST00000350356 K04345 4 0.53328 1.3515 0.66439 0.79541 0.85287 0.95957 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle developmental process;keratinization 7 7 7 17 17 17 52.736 2.5129E-30 147590000 78929000 68660000 4601 IPI:IPI00410039.1;IPI:IPI00410040.3;IPI:IPI00396937.1;IPI:IPI00152093.3;IPI:IPI00855705.1;IPI:IPI00397558.1;IPI:IPI00410044.1 Periphilin-1;Gastric cancer antigen Ga50 PPHLN1;HSPC206;HSPC232 Q8NEY8-1;Q8NEY8;Q8NEY8-2;Q8NEY8-8;Q8NEY8-3;Q8NEY8-6 ENST00000256678;ENST00000337898;ENST00000358314;ENST00000395568;ENST00000395580 7 0.72464 1.3652 0.72659 1.0372 0.82839 0.99848 zf-CCCH cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;nucleic acid binding;RNA binding;transition metal ion binding;zinc ion binding 13 13 13 21.9 21.9 21.9 82.875 2.0094E-65 449450000 234360000 215090000 4603 IPI:IPI00397376.1;IPI:IPI00890821.1;IPI:IPI00890689.1;IPI:IPI00426049.3;IPI:IPI00451437.1;IPI:IPI00168501.3;IPI:IPI00168449.1;IPI:IPI00291357.2 Zinc finger CCCH domain-containing protein 14;Renal carcinoma antigen NY-REN-37 ZC3H14 Q6PJT7-1;Q6PJT7;Q6PJT7-2;Q6PJT7-5;Q6PJT7-7;Q6PJT7-3;Q6PJT7-4 ENST00000251038;ENST00000302216;ENST00000318308;ENST00000336693;ENST00000359301;ENST00000380684 8 NaN 0.4372 NaN NaN 0.30281 NaN Peptidase_C50 centrosome;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;microtubule organizing center;non-membrane-bounded organelle;nucleus;organelle;organelle part binding;catalytic activity;cysteine-type peptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides;protein binding apoptosis;cytokinesis;cytoskeleton organization;microtubule cytoskeleton organization;microtubule-based process;mitotic sister chromatid segregation;organelle organization;proteolysis;regulation of sister chromatid cohesion;sister chromatid segregation Cell cycle;Cell cycle - yeast 3 3 3 1.1 1.1 1.1 233.11 2.2817E-05 1046400 335280 711130 4604 IPI:IPI00397474.1;IPI:IPI00017538.3 Separin;Separase;Caspase-like protein ESPL1;Extra spindle poles-like 1 protein ESPL1;ESP1;KIAA0165 Q14674-1;Q14674;Q14674-2 ENST00000257934 K02365 2 0.015561 35.493 0.071439 0.021593 25.812 0.089258 efhand;Filaggrin;S_100;SVS_QK binding;calcium ion binding;cation binding;ion binding;metal ion binding;structural molecule activity + 6 6 6 3.6 3.6 3.6 248.07 2.3101E-44 29565000 29251000 313540 4606 IPI:IPI00397801.4 Filaggrin-2;Intermediate filament-associated and psoriasis-susceptibility protein FLG2;IFPS Q5D862 ENST00000388718 K10384 1 0.77649 1.6388 0.80853 0.99246 1.1027 1.0023 FERM_M;PH cell part;cytoplasm;intracellular part;membrane;plasma membrane binding;protein binding biological adhesion;cell adhesion;cellular process 30 30 30 54.1 54.1 54.1 75.952 0 2176100000 1181500000 994600000 4607 IPI:IPI00397834.1;IPI:IPI00216699.1 Fermitin family homolog 3;Unc-112-related protein 2;Kindlin-3;MIG2-like protein FERMT3;KIND3;MIG2B;URP2 Q86UX7-1;Q86UX7;Q86UX7-2 ENST00000279227;ENST00000345728 2 NaN 1.896 0.93469 NaN 1.1767 1.1911 2 2 2 8.5 8.5 8.5 37.976 2.9994E-27 12832000 6263300 6568400 4608 IPI:IPI00397883.6 Uncharacterized protein FLJ45252 Q6ZSR9 ENST00000339092 1 NaN 1.6526 NaN NaN 0.90237 NaN Adaptin_N clathrin coated vesicle membrane;coated vesicle membrane;cytoplasmic vesicle membrane;Golgi apparatus;intracellular organelle;macromolecular complex;membrane;membrane coat;membrane-bounded organelle;organelle;organelle membrane;vesicle membrane binding;enzyme binding;phosphatase binding;protein binding;protein phosphatase binding;protein transporter activity;substrate-specific transporter activity;transporter activity cellular component organization;cellular process;endocytosis;establishment of localization;membrane invagination;membrane organization;transport;vesicle-mediated transport 4 1 1 9 2.1 2.1 63.77 2.3558E-29 364420 223930 140490 4609 IPI:IPI00397887.2 AP-3 complex subunit beta-1;Adapter-related protein complex 3 subunit beta-1;Adaptor protein complex AP-3 beta-1 subunit;Beta3A-adaptin;Clathrin assembly protein complex 3 beta-1 large chain AP3B1;ADTB3A O00203-2;O00203 ENST00000255194 K12397 1 0.60547 1.1026 0.63182 0.76556 0.7562 0.7943 Nic96 cell part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;organelle part;pore complex;protein complex binding;protein binding cellular process;establishment of protein localization;intracellular protein transport;intracellular transport;mRNA transport;nucleic acid transport;nucleobase, nucleoside, nucleotide and nucleic acid transport;protein transport;RNA transport;transport 31 31 31 39.1 39.1 39.1 93.487 0 1746500000 953270000 793180000 4610 IPI:IPI00397904.6 Nuclear pore complex protein Nup93;Nucleoporin Nup93;93 kDa nucleoporin NUP93;KIAA0095 Q8N1F7 ENST00000308159 1 0.73158 1.2913 NaN 0.90296 0.90977 NaN PH;RhoGAP;SH3_1;WW cell part;cytoplasm;intracellular part;membrane binding;enzyme activator activity;enzyme regulator activity;GTPase activator activity;protein binding;protein domain specific binding;Ras GTPase activator activity;Rho GTPase activator activity;SH3 domain binding;small GTPase regulator activity cell communication;cellular component organization;cellular process;endocytosis;membrane invagination;membrane organization;receptor-mediated endocytosis;regulation of Ras GTPase activity;signal transduction;transport;vesicle-mediated transport 3 3 3 4.6 4.6 4.6 98.386 1.3393E-06 19893000 10756000 9137500 4612 IPI:IPI00885078.1;IPI:IPI00398170.3;IPI:IPI00885118.1 Rho GTPase-activating protein 27;Rho-type GTPase-activating protein 27;CIN85-associated multi-domain-containing Rho GTPase-activating protein 1 ARHGAP27;CAMGAP1;PP905 Q6ZUM4-1;Q6ZUM4;Q6ZUM4-2;Q6ZUM4-3 ENST00000290470;ENST00000330929;ENST00000376922 3 0.80155 1.7444 0.88086 1.0151 1.232 1.1044 CBS;Voltage_CLC cell surface;early endosome membrane;endosome membrane;Golgi membrane;integral to membrane;intracellular part;intrinsic to membrane;late endosome membrane;membrane;membrane part;organelle membrane;organelle part;plasma membrane;vesicle membrane anion channel activity;binding;chloride channel activity;ion channel activity;protein binding;transporter activity;voltage-gated anion channel activity;voltage-gated chloride channel activity;voltage-gated ion channel activity anion transport;cellular cation homeostasis;cellular homeostasis;cellular ion homeostasis;cellular monovalent inorganic cation homeostasis;cellular process;chloride transport;inorganic anion transport;ion transport;regulation of pH;transport 3 3 3 3 3 3 97.008 0.00049462 32944000 15927000 17017000 4613 IPI:IPI00398349.2;IPI:IPI00413568.2 H(+)/Cl(-) exchange transporter 3;Chloride transporter ClC-3;Chloride channel protein 3 CLCN3 P51790-1;P51790;P51790-2 ENST00000347613;ENST00000360642 K05012 2 0.19883 1.4048 NaN 0.27257 0.78773 NaN SAM_1;SAM_2 cell part;cell surface;cytoplasm;intracellular part binding;protein binding 5 3 3 4.5 2.7 2.7 133.49 1.5499E-29 1845500 1164000 681440 4614 IPI:IPI00398364.3;IPI:IPI00398365.3 Liprin-alpha-3;Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3 PPFIA3;KIAA0654 O75145-1;O75145;O75145-2 ENST00000334186;ENST00000334329 2 0.27375 NaN NaN 0.35842 NaN NaN Pkinase cell junction;cell part;cell-cell junction;membrane part;occluding junction;plasma membrane part;tight junction ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cell communication;cellular process;intracellular signaling cascade;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein kinase cascade;protein modification process;signal transduction 4 2 1 4.8 2.1 1.2 73.369 1.9686E-05 29870000 16969000 12901000 4615 IPI:IPI00398442.3 Serine/threonine-protein kinase WNK4;Protein kinase with no lysine 4;Protein kinase, lysine-deficient 4 WNK4;PRKWNK4 Q96J92-2;Q96J92 ENST00000246914;ENST00000316085 K08867 1 0.5717 NaN 0.48341 0.76922 NaN 0.63586 zf-C2H2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 2 2 2 1.8 1.8 1.8 149.56 1.2707E-06 1297500 780790 516690 4617 IPI:IPI00398725.1;IPI:IPI00479590.1 Zinc finger protein 644;Zinc finger motif enhancer-binding protein 2 ZNF644;KIAA1221;ZEP2 Q9H582-1;Q9H582;Q9H582-2 ENST00000337393;ENST00000347275;ENST00000361321;ENST00000370440;ENST00000394578 2 0.76963 1.6693 0.77806 0.98143 1.1435 1.012 Abhydrolase_2 cell part;cytoplasm;intracellular part carboxylesterase activity;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;lipase activity;lysophospholipase activity;phospholipase activity carboxylic acid metabolic process;cellular ketone metabolic process;cellular process;fatty acid metabolic process;lipid metabolic process;metabolic process;monocarboxylic acid metabolic process;organic acid metabolic process;oxoacid metabolic process Glycerophospholipid metabolism 5 5 5 31.3 31.3 31.3 24.669 4.0298E-41 64950000 35453000 29497000 4618 IPI:IPI00939508.1;IPI:IPI00398727.3 Acyl-protein thioesterase 1;Lysophospholipase 1;Lysophospholipase I LYPLA1;APT1;LPL1 O75608-1;O75608;O75608-2 ENST00000316963;ENST00000343231 K06128 2 NaN 1.7348 0.88166 NaN 1.2071 1.1378 Golgin_A5 8 8 8 17.6 17.6 17.6 57.005 4.2856E-31 34674000 17481000 17193000 4619 IPI:IPI00941851.1;IPI:IPI00398786.1 Uncharacterized protein C14orf133 C14orf133 Q9H9C1-1;Q9H9C1;Q9H9C1-2 ENST00000327028;ENST00000343765 2 0.93835 1.5439 0.8512 1.156 1.1018 1.2032 Reticulon endoplasmic reticulum membrane;extracellular region part;extracellular space;Golgi apparatus part;Golgi membrane;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part apoptosis;cell death;cellular process;death;establishment of localization;interspecies interaction between organisms;multi-organism process;programmed cell death;response to stimulus;response to stress;transport;vesicle-mediated transport 3 3 3 2.6 2.6 2.6 112.61 2.5468E-26 69357000 34686000 34671000 4620 IPI:IPI00743293.2;IPI:IPI00398795.4;IPI:IPI00412154.4;IPI:IPI00028946.2 Reticulon-3;Neuroendocrine-specific protein-like 2;NSP-like protein II RTN3;ASYIP;NSPL2 O95197-1;O95197;O95197-2;O95197-4;O95197-3 ENST00000339997;ENST00000341307;ENST00000354497;ENST00000356000;ENST00000377819 4 0.89572 1.4764 1.1498 1.1353 1.05 1.4392 Rab5-bind;TPR_1 cell part;cytoskeletal part;intracellular organelle part;intracellular part;kinesin complex;macromolecular complex;microtubule;microtubule associated complex;organelle part;protein complex binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;microtubule motor activity;motor activity;protein binding;pyrophosphatase activity 10 6 6 19.3 13.5 13.5 70.551 3.2822E-52 7358300 3811300 3547000 4621 IPI:IPI00743879.1;IPI:IPI00398812.5;IPI:IPI00788630.2;IPI:IPI00465074.2;IPI:IPI00478456.1;IPI:IPI00736469.1 Kinesin light chain 4;Kinesin-like protein 8 KLC4;KNSL8 Q9NSK0-3;Q9NSK0;Q9NSK0-1 ENST00000259708;ENST00000347162;ENST00000394056;ENST00000394058 6 0.31362 0.56811 0.37054 0.38937 0.40564 0.46538 PAS;Pkinase cell part;cytoplasm;intracellular part ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;signal transducer activity;transferase activity cell communication;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;regulation of biosynthetic process;regulation of transcription, DNA-dependent;signal transduction 4 4 4 4.8 4.8 4.8 142.93 4.504E-12 14201000 8462800 5738200 4622 IPI:IPI00398824.2;IPI:IPI00398825.4 PAS domain-containing serine/threonine-protein kinase PASK;KIAA0135 Q96RG2-1;Q96RG2;Q96RG2-2 ENST00000234040;ENST00000358649;ENST00000405260 K08801 2 0.718 1.4378 0.69395 0.95342 1.0192 0.90661 FCH;RhoGAP;SH3_1 adherens junction;cell junction;cell-substrate adherens junction;cell-substrate junction;cytoplasm;focal adhesion;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;enzyme activator activity;enzyme regulator activity;GTPase activator activity;protein binding;Ras GTPase activator activity;Rho GTPase activator activity;SH3/SH2 adaptor activity;signal transducer activity;small GTPase regulator activity cell communication;cellular process;cytoskeleton organization;intracellular signaling cascade;organelle organization;Ras protein signal transduction;Rho protein signal transduction;signal transduction;small GTPase mediated signal transduction 14 14 14 20.3 20.3 20.3 105.02 3.5258E-114 147590000 75618000 71970000 4623 IPI:IPI00398854.2 Rho GTPase-activating protein 4;Rho-type GTPase-activating protein 4;Rho-GAP hematopoietic protein C1;p115 ARHGAP4;KIAA0131;RGC1;RHOGAP4 P98171 ENST00000350060;ENST00000370028 1 0.64449 NaN 0.6849 0.83536 NaN 0.90415 PP1_inhibitor cell part;cytoplasm;intracellular part binding;enzyme inhibitor activity;enzyme regulator activity;phosphatase inhibitor activity;phosphatase regulator activity;phosphoprotein phosphatase inhibitor activity;protein binding;protein phosphatase regulator activity regulation of biological process;regulation of cellular metabolic process;regulation of cellular process;regulation of metabolic process;regulation of phosphate metabolic process;regulation of phosphorus metabolic process;regulation of phosphorylation 2 2 2 23.6 23.6 23.6 20.964 2.6398E-09 111910000 59721000 52191000 4624 IPI:IPI00398922.4 Protein phosphatase 1 regulatory subunit 14B;Phospholipase C beta 3 neighbouring gene protein PPP1R14B;PLCB3N;PNG Q96C90 ENST00000309318 1 0.49245 0.92056 0.44707 0.68335 0.65871 0.55556 Ank binding;protein binding 7 7 7 10 10 10 115.06 3.3106E-18 21756000 12502000 9254000 4625 IPI:IPI00398957.5 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C;Ankyrin repeat domain-containing protein 52 ANKRD52 Q8NB46 ENST00000267116 1 0.85223 1.3874 0.94329 1.1345 0.9432 1.2633 COG6 cell part;cytoplasmic part;Golgi apparatus part;Golgi membrane;Golgi transport complex;intracellular organelle part;intracellular part;macromolecular complex;membrane;organelle membrane;organelle part;protein complex establishment of localization;establishment of protein localization;protein transport;transport 7 7 7 13.2 13.2 13.2 73.278 9.9382E-57 25383000 12674000 12709000 4626 IPI:IPI00940437.1;IPI:IPI00398963.4;IPI:IPI00889669.1 Conserved oligomeric Golgi complex subunit 6;Component of oligomeric Golgi complex 6 COG6;KIAA1134 Q9Y2V7-1;Q9Y2V7;Q9Y2V7-2;Q9Y2V7-3 ENST00000255468 3 0.59456 0.93581 0.613 0.811 0.58608 0.769 BRK;Chromo;Helicase_C;SNF2_N cell part;chromatin;chromosomal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;organelle part;protein complex ATP binding;beta-catenin binding;binding;catalytic activity;chromatin binding;DNA binding;DNA helicase activity;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;p53 binding;protein binding;purine nucleoside binding chromatin assembly or disassembly;chromatin organization;chromatin remodeling;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription Wnt signaling pathway 10 7 5 4.3 3.1 2.4 290.51 1.0276E-51 24589000 13662000 10927000 4627 IPI:IPI00398992.6;IPI:IPI00719073.2;IPI:IPI00395823.3 Chromodomain-helicase-DNA-binding protein 8;ATP-dependent helicase CHD8;Helicase with SNF2 domain 1 CHD8;HELSNF1;KIAA1564 Q9HCK8-1;Q9HCK8;Q9HCK8-2 ENST00000262707;ENST00000399982 K04494 3 0.67183 1.6441 0.83747 0.81928 1.2084 1.1056 DUF498 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 4 4 4 22.3 22.3 22.3 20.35 2.8251E-38 146960000 84152000 62810000 4628 IPI:IPI00399053.4 Uncharacterized protein C3orf60 C3orf60 Q9BU61 ENST00000326925 K09008 1 0.72653 1.7972 0.77843 1.0349 1.1383 1.0863 Mesd anatomical structure development;developmental process;mesoderm development;tissue development 6 6 6 34.2 34.2 34.2 26.076 1.259E-72 233590000 130000000 103590000 4629 IPI:IPI00399089.4 Mesoderm development candidate 2;Renal carcinoma antigen NY-REN-61 MESDC2;KIAA0081;UNQ1911/PRO4369 Q14696 ENST00000261758 1 0.61224 2.2511 NaN 0.83983 1.4656 NaN PPTA catalytic activity;prenyltransferase activity;protein prenyltransferase activity;transferase activity;transferase activity, transferring alkyl or aryl (other than methyl) groups cellular biopolymer metabolic process;cellular process;macromolecule metabolic process;metabolic process;protein amino acid lipidation;protein amino acid prenylation;protein metabolic process;protein modification process;protein prenylation 2 2 2 4.7 4.7 4.7 46.405 0.00062523 1521400 930840 590550 4630 IPI:IPI00399115.5 Protein prenyltransferase alpha subunit repeat-containing protein 1 PTAR1 Q7Z6K3 ENST00000340434;ENST00000377200 1 0.18962 0.79462 NaN 0.25312 0.55023 NaN RCC1 2 2 2 7.2 7.2 7.2 40.078 7.2034E-07 6750400 3925600 2824800 4631 IPI:IPI00399158.4 RCC1 domain-containing protein 1 RCCD1 A6NED2 ENST00000300233;ENST00000394258 1 0.66457 NaN NaN 0.88807 NaN NaN OTU binding;protein binding 3 3 3 3.9 3.9 3.9 124.04 0.0021775 12010000 6097200 5912700 4632 IPI:IPI00399254.3 OTU domain-containing protein 4;HIV-1-induced protein HIN-1 OTUD4;HIN1;KIAA1046 Q01804-1;Q01804 ENST00000394097 1 0.48466 1.09 0.50172 0.65451 0.69643 0.66168 S1 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;nucleic acid binding;protein binding;RNA binding;transcription factor binding cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 39 39 39 24.3 24.3 24.3 208.7 0 1069300000 423110000 646190000 4633 IPI:IPI00400922.5;IPI:REV_IPI00413233.3 Protein RRP5 homolog;Programmed cell death protein 11;NF-kappa-B-binding protein PDCD11;KIAA0185 Q14690 ENST00000369797 2 0.68597 1.9924 0.95053 0.95757 1.2133 1.2138 K_tetra cation channel complex;cell part;ion channel complex;macromolecular complex;membrane part;plasma membrane part;potassium channel complex;protein complex;voltage-gated potassium channel complex binding;cation channel activity;cation transmembrane transporter activity;ion channel activity;potassium channel activity;protein binding;transporter activity;voltage-gated ion channel activity;voltage-gated potassium channel activity cation transport;establishment of localization;ion transport;metal ion transport;monovalent inorganic cation transport;potassium ion transport;transport 2 2 2 8.1 8.1 8.1 29.643 0.003325 34277000 19021000 15255000 4634 IPI:IPI00400983.3;IPI:IPI00644763.2 BTB/POZ domain-containing protein KCTD21;BTB/POZ domain-containing protein KCTD1 KCTD21;KCTD1;C18orf5 Q4G0X4;Q719H9 ENST00000340067;ENST00000317932;ENST00000408011 2 0.95323 2.615 NaN 1.3672 1.6138 NaN PTPLA cell part;integral to membrane;intrinsic to membrane;membrane part 2 2 2 4.3 4.3 4.3 27.52 0.0035848 5092200 2999800 2092400 4636 IPI:IPI00401243.3 Protein tyrosine phosphatase-like protein PTPLAD2;Protein-tyrosine phosphatase-like A domain-containing protein 2 PTPLAD2 Q5VWC8 ENST00000380233 1 0.98487 1.8134 0.9889 1.328 1.1832 1.3096 Thioredoxin cytoplasmic part;endoplasmic reticulum lumen;endoplasmic reticulum membrane;endoplasmic reticulum part;ER-Golgi intermediate compartment;intracellular part;membrane;membrane part;membrane-enclosed lumen;organelle lumen;organelle membrane;organelle part binding;catalytic activity;intramolecular oxidoreductase activity;intramolecular oxidoreductase activity, interconverting keto- and enol-groups;isomerase activity;protein binding;protein disulfide isomerase activity cellular homeostasis;cellular process;glycoprotein metabolic process;metabolic process;protein folding;protein metabolic process;response to biotic stimulus;response to organic substance;response to stress;response to unfolded protein 11 11 11 33.3 33.3 33.3 46.971 1.7106E-185 386600000 189830000 196770000 4637 IPI:IPI00401264.5 Endoplasmic reticulum resident protein ERp44;Thioredoxin domain-containing protein 4 ERP44;KIAA0573;TXNDC4;UNQ532/PRO1075 Q9BS26 ENST00000262455 1 0.54973 1.1443 0.60505 0.77637 0.71799 0.80902 Methyltransf_11 arginine N-methyltransferase activity;binding;catalytic activity;methyltransferase activity;N-methyltransferase activity;protein methyltransferase activity;S-adenosylmethionine-dependent methyltransferase activity;zinc ion binding 8 8 8 18.3 18.3 18.3 59.902 9.0526E-48 80970000 43890000 37080000 4640 IPI:IPI00401321.1 Protein arginine N-methyltransferase 3;Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3 PRMT3;HRMT1L3 O60678 ENST00000330796;ENST00000331079 K11436 1 NaN 1.3939 8.5736 NaN 0.88058 11.891 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 2 2 2 4.9 4.9 4.9 64.845 0.00066267 37874000 3685400 34189000 4641 IPI:IPI00401900.1;IPI:IPI00640905.1;IPI:IPI00385543.1 UPF0469 protein KIAA0907 KIAA0907;BLOM7 Q7Z7F0-1;Q7Z7F0;Q7Z7F0-2;Q7Z7F0-3 ENST00000368321 3 0.57143 0.9807 0.56915 0.71673 0.67298 0.79562 7 7 7 30.1 30.1 30.1 33.231 4.832E-127 73566000 38877000 34689000 4642 IPI:IPI00401962.2 Coiled-coil domain-containing protein 137 CCDC137 Q6PK04 ENST00000329214 1 0.55948 0.94844 0.79889 0.71833 0.66579 0.97051 RPAP1_C;RPAP1_N cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;DNA binding;DNA-directed RNA polymerase activity;nucleic acid binding;nucleotidyltransferase activity;RNA polymerase activity;transferase activity;transferase activity, transferring phosphorus-containing groups biosynthetic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription 8 8 8 6 6 6 152.75 1.4599E-75 61531000 31836000 29695000 4644 IPI:IPI00402657.4;IPI:IPI00844387.1;IPI:IPI00844376.1 RNA polymerase II-associated protein 1 RPAP1;KIAA1403 Q9BWH6-1;Q9BWH6;Q9BWH6-2 ENST00000304330 3 NaN 1.7258 NaN NaN 1.1578 NaN cell part;intracellular binding;enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity;protein binding biological regulation;regulation of biological process;regulation of cell communication;regulation of cellular process;regulation of signal transduction;regulation of small GTPase mediated signal transduction 5 5 5 2.4 2.4 2.4 166.8 5.954E-06 1732000 1053600 678380 4645 IPI:IPI00409601.1;IPI:IPI00410120.1;IPI:IPI00748653.2;IPI:IPI00936060.1 Protein KIAA1219 KIAA1219 Q86X10-1;Q86X10;Q86X10-3;Q86X10-2 ENST00000262879;ENST00000304939;ENST00000397038;ENST00000397040 4 0.91838 1.8584 1.2381 1.1596 1.3257 1.5921 Homeobox;TRAM_LAG1_CLN8 cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;nuclear membrane;nuclear part;organelle membrane;organelle part binding;DNA binding;nucleic acid binding;sequence-specific DNA binding;transcription factor activity;transcription regulator activity regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent 4 4 4 12 12 12 44.889 8.0442E-17 63522000 30565000 32957000 4646 IPI:IPI00409608.3 LAG1 longevity assurance homolog 6 LASS6 Q6ZMG9 ENST00000305747;ENST00000392687 1 0.58876 1.286 0.63433 0.79537 0.80871 0.79704 C2 cell part;integral to membrane;intrinsic to membrane;membrane;membrane part;plasma membrane 22 22 1 26.4 26.4 2.6 98.9 8.0314E-222 829550000 430470000 399080000 4647 IPI:IPI00409635.2;IPI:IPI00827920.1;IPI:IPI00827794.1;IPI:IPI00827663.1 Extended synaptotagmin-2;Chr2Syt;Protein FAM62B FAM62B;ESYT2;KIAA1228 A0FGR8-2;A0FGR8;A0FGR8-1;A0FGR8-4 ENST00000251527 4 0.86138 1.3166 0.78392 1.0918 0.91165 1.0331 UBA;ubiquitin cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;nucleus;organelle;plasma membrane binding 9 6 6 19.4 12.7 12.7 65.695 4.4329E-180 169350000 86017000 83331000 4648 IPI:IPI00409659.2 Ubiquilin-2;Protein linking IAP with cytoskeleton 2;Ubiquitin-like product Chap1/Dsk2;DSK2 homolog;Chap1 UBQLN2;N4BP4;PLIC2;HRIHFB2157 Q9UHD9 ENST00000338222 K04523 1 0.69228 1.5276 0.89657 0.93222 0.98216 1.1489 DEAD;Helicase_C Cajal body;cell part;intracellular organelle part;intracellular part;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part ATP binding;ATP-dependent helicase activity;binding;catalytic activity;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity;RNA binding 15 15 15 19.8 19.8 19.8 102.97 2.471E-150 245210000 124020000 121200000 4649 IPI:IPI00409671.3;IPI:IPI00829889.1 ATP-dependent RNA helicase DDX42;DEAD box protein 42;Splicing factor 3B-associated 125 kDa protein;RNA helicase-related protein;RNA helicase-like protein;SF3b DEAD-box protein DDX42 Q86XP3-1;Q86XP3;Q86XP3-2 ENST00000359353;ENST00000389924 2 0.67303 1.2412 0.54102 0.88598 0.75828 0.73097 MRG chromatin remodeling complex;H4/H2A histone acetyltransferase complex;histone acetyltransferase complex;histone deacetylase complex;macromolecular complex;NuA4 histone acetyltransferase complex;organelle part;protein complex;Sin3 complex binding;protein binding chromatin organization;DNA metabolic process;DNA repair;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein amino acid acetylation;protein modification process;regulation of transcription, DNA-dependent;transcription 4 2 2 14.4 7.5 7.5 41.473 1.4969E-40 66740000 43227000 23512000 4650 IPI:IPI00409675.1;IPI:IPI00930346.1 Mortality factor 4-like protein 1;MORF-related gene 15 protein;Transcription factor-like protein MRG15;MSL3-1 protein MORF4L1;MRG15;FWP006;HSPC008;HSPC061;PP368 Q9UBU8-1;Q9UBU8;Q9UBU8-2 ENST00000331268;ENST00000379535 K11339 2 0.80691 NaN NaN 1.0332 NaN NaN Choline_kinase cell part;cytoplasm;intracellular part ATP binding;binding;catalytic activity;choline kinase activity;kinase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;signal transducer activity;transferase activity;transferase activity, transferring phosphorus-containing groups establishment of localization;lipid transport;transport Glycerophospholipid metabolism;Glycine, serine and threonine metabolism 2 2 2 4.8 4.8 4.8 52.248 3.5958E-19 1758600 930640 827980 4651 IPI:IPI00409761.2;IPI:IPI00409762.2 Choline kinase alpha;CHETK-alpha CHKA;CHK;CKI P35790-1;P35790;P35790-2 ENST00000265689;ENST00000356135 K00866 2 0.91978 1.6326 0.83582 1.1927 1.0971 1.1075 PARP;zf-CCCH cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;ion binding;NAD+ ADP-ribosyltransferase activity;nucleic acid binding;RNA binding;transferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring pentosyl groups;zinc ion binding multi-organism process;response to biotic stimulus;response to other organism;response to stimulus;response to virus 29 29 28 37.3 37.3 36.4 101.43 0 1231100000 629740000 601330000 4652 IPI:IPI00410067.2;IPI:IPI00410069.4;IPI:IPI00332936.1;IPI:IPI00410070.2;IPI:IPI00410071.3 Zinc finger CCCH-type antiviral protein 1;Zinc finger CCCH domain-containing protein 2;Zinc finger antiviral protein ZC3HAV1;ZC3HDC2;PRO1677 Q7Z2W4-1;Q7Z2W4;Q7Z2W4-3;Q7Z2W4-2 ENST00000242351 5 0.84177 1.7509 0.81346 1.1007 1.1733 1.1132 integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane;membrane-bounded organelle;microtubule;mitochondrial membrane;nucleus;organelle;organelle membrane;organelle part binding;protein binding apoptosis;cell death;cell differentiation;cellular developmental process;cellular process;death;developmental process;programmed cell death 5 5 5 13 13 13 52.118 5.5173E-21 76622000 38923000 37699000 4653 IPI:IPI00410079.3;IPI:IPI00845345.1 Regulator of microtubule dynamics protein 3;Protein FAM82A2;Protein FAM82C;Protein tyrosine phosphatase-interacting protein 51;TCPTP-interacting protein 51;Cerebral protein 10 FAM82A2;FAM82C;PTPIP51;hucep-10;UNQ3122/PRO10274 Q96TC7-1;Q96TC7;Q96TC7-2 ENST00000260385;ENST00000338376 2 1.6433 2.9546 1.6181 2.116 2.0197 2.0007 DUF775 cell part;cytoplasm;intracellular part 6 6 6 27.9 27.9 27.9 21.627 2.0699E-70 354670000 160200000 194480000 4654 IPI:IPI00410091.3 Uncharacterized protein C11orf73 C11orf73;HSPC138;HSPC179;HSPC248 Q53FT3 ENST00000278483 1 0.59138 1.0911 0.63466 0.79633 0.69637 0.84824 2 2 2 9.6 9.6 9.6 21.957 2.3491E-24 14539000 8045100 6493500 4655 IPI:IPI00783733.3;IPI:IPI00410094.2 Protein FAM128A;Protein FAM128B FAM128A;FAM128B Q6P582;Q6NZ67 ENST00000309451;ENST00000410036;ENST00000281871;ENST00000409255 2 NaN 2.193 0.45409 NaN 1.2863 0.57181 cell part;cell projection;cilium anatomical structure formation;cell projection assembly;cell projection organization;cellular component assembly;cellular component organization;cellular process;cilium assembly 2 2 2 1.8 1.8 1.8 197.57 8.7645E-12 27728000 17626000 10102000 4656 IPI:IPI00410096.1 Intraflagellar transport protein 172 homolog IFT172;KIAA1179 Q9UG01-1;Q9UG01 ENST00000260570 1 0.80574 NaN 0.63767 1.0852 NaN 0.85414 Prenyltransf binding;catalytic activity;protein binding;transferase activity;transferase activity, transferring alkyl or aryl (other than methyl) groups 2 2 2 6 6 6 38.785 7.0709E-14 2936900 1798900 1138000 4657 IPI:IPI00514787.5;IPI:IPI00410097.2;IPI:IPI00410099.4 Dehydrodolichyl diphosphate synthase DHDDS;HDS Q86SQ9-2;Q86SQ9;Q86SQ9-1;Q86SQ9-3 ENST00000236342;ENST00000357049;ENST00000360009 K11778 3 0.51443 0.90382 0.47579 0.67499 0.55841 0.65162 DUF1605;HA2;Helicase_C ATP binding;ATP-dependent helicase activity;binding;catalytic activity;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity 5 5 5 7.8 7.8 7.8 88.559 4.9025E-49 40891000 24592000 16299000 4658 IPI:IPI00410110.3;IPI:IPI00797226.1;IPI:IPI00789290.2 Probable ATP-dependent RNA helicase DHX40;DEAH box protein 40;Protein PAD DHX40;DDX40;ARG147 Q8IX18-1;Q8IX18;Q8IX18-3;Q8IX18-2 ENST00000251241 3 0.75161 1.5486 0.73906 1.0291 0.99445 1.0088 Inositol_P cell part;cytoplasmic part;cytosol;intracellular part 3'(2'),5'-bisphosphate nucleotidase activity;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;inositol or phosphatidylinositol phosphatase activity;magnesium ion binding;nucleotidase activity;phosphatase activity cellular metabolic process;cellular process;developmental process;metabolic process;nervous system development;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;primary metabolic process Sulfur metabolism 14 14 14 44.2 44.2 44.2 33.392 0 650760000 346720000 304040000 4660 IPI:IPI00410214.1;IPI:IPI00410215.6 3'(2'),5'-bisphosphate nucleotidase 1;Bisphosphate 3'-nucleotidase 1;PAP-inositol-1,4-phosphatase BPNT1 O95861-1;O95861;O95861-2 ENST00000302686;ENST00000322067 K01082 2 0.94266 1.4066 0.7549 1.2139 0.98422 0.9761 BRCT;FCP1_C;NIF cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part catalytic activity;DNA-directed RNA polymerase activity;hydrolase activity;nucleotidyltransferase activity;phosphoprotein phosphatase activity;transferase activity;transferase activity, transferring phosphorus-containing groups cellular biopolymer metabolic process;cellular process;dephosphorylation;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid dephosphorylation;protein metabolic process;protein modification process 6 6 6 8.4 8.4 8.4 104.3 1.7885E-81 23724000 12603000 11121000 4661 IPI:IPI00410256.1;IPI:IPI00410257.1;IPI:IPI00410258.1 RNA polymerase II subunit A C-terminal domain phosphatase;TFIIF-associating CTD phosphatase CTDP1;FCP1 Q9Y5B0-1;Q9Y5B0;Q9Y5B0-2;Q9Y5B0-3 ENST00000075430;ENST00000299543 K01090 3 0.82554 1.4052 0.81293 1.0202 0.9757 1.0393 RRM_1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of heart contraction;RNA metabolic process;RNA processing 13 13 10 28.8 28.8 23.8 55.754 2.1963E-261 706060000 358700000 347350000 4662 IPI:IPI00410277.3;IPI:IPI00845479.1;IPI:IPI00845480.1;IPI:IPI00607544.4;IPI:IPI00853320.1 CUG-BP- and ETR-3-like factor 2;Bruno-like protein 3;RNA-binding protein BRUNOL-3;CUG triplet repeat RNA-binding protein 2;ELAV-type RNA-binding protein 3;Neuroblastoma apoptosis-related RNA-binding protein CUGBP2;BRUNOL3;CELF2;ETR3;NAPOR O95319-3;O95319;O95319-4;O95319-1;O95319-2;O95319-5 ENST00000379261;ENST00000399850 5 0.58019 1.1505 0.58553 0.77216 0.77175 0.78312 zf-CCHC binding;cation binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding 3 3 3 12.5 12.5 12.5 30.477 8.6393E-21 8756800 5289700 3467100 4663 IPI:IPI00410284.6 Zinc finger CCHC domain-containing protein 9 ZCCHC9 Q8N567 ENST00000254037;ENST00000380199;ENST00000407610 1 0.75369 1.4673 0.7006 0.98763 0.9732 0.92739 Pkinase cell part;intracellular catalytic activity;cyclic nucleotide-dependent protein kinase activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding activation of MAPK activity;alcohol metabolic process;fatty acid biosynthetic process;fatty acid metabolic process;lipid metabolic process;organic acid metabolic process;protein amino acid phosphorylation;protein modification process;response to hypoxia Adipocytokine signaling pathway;Insulin signaling pathway;mTOR signaling pathway;Regulation of autophagy 17 17 14 32.6 32.6 23.9 65.522 0 475370000 251770000 223610000 4664 IPI:IPI00410287.3;IPI:IPI00792482.1 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1;AMPK1 Q13131-2;Q13131;Q13131-1 ENST00000254690;ENST00000354209;ENST00000397128 K07198 2 0.90441 1.5103 0.81921 1.1902 1.0162 1.0627 AD binding;protein binding 4 4 4 29.3 29.3 29.3 21.999 7.7668E-37 194960000 69302000 125660000 4666 IPI:IPI00867714.1;IPI:IPI00410324.2 Protein LSM12 homolog LSM12 Q3MHD2-2;Q3MHD2;Q3MHD2-1 ENST00000293406 2 0.82838 1.3071 0.71836 1.0532 0.9211 0.9495 GATA chromatin remodeling complex;histone deacetylase complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear body;nuclear part;nuclear speck;NuRD complex;organelle part;protein complex;transcriptional repressor complex binding;cation binding;DNA binding;ion binding;nucleic acid binding;protein binding;protein binding, bridging;sequence-specific DNA binding;transcription factor activity;transcription regulator activity;transcription repressor activity;zinc ion binding DNA alkylation;DNA metabolic process;DNA methylation;DNA modification;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;one-carbon metabolic process;regulation of transcription, DNA-dependent;transcription 19 19 18 36 36 34.3 68.062 1.1306E-161 398920000 204350000 194580000 4667 IPI:IPI00410330.3;IPI:IPI00444526.1 Transcriptional repressor p66-alpha;Hp66alpha;GATA zinc finger domain-containing protein 2A GATAD2A Q86YP4-1;Q86YP4;Q86YP4-2 ENST00000252577;ENST00000358713;ENST00000404158 2 0.44108 0.82461 NaN 0.54732 0.49306 NaN Thymidylate_kin cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle ATP binding;binding;catalytic activity;cytidylate kinase activity;kinase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;pyrimidine nucleotide biosynthetic process;pyrimidine nucleotide metabolic process Pyrimidine metabolism 5 5 5 12 12 12 49.375 8.6248E-125 24130000 11093000 13037000 4668 IPI:IPI00410404.3;IPI:IPI00890710.1;IPI:IPI00830006.1;IPI:IPI00884425.1 UMP-CMP kinase 2, mitochondrial CMPK2 Q5EBM0-1;Q5EBM0;Q5EBM0-4;Q5EBM0-3 ENST00000256722 K00945 4 0.49511 1.0361 0.4554 0.68233 0.6547 0.6326 Pkinase cell part;cytoplasm;intracellular part;membrane;plasma membrane ATP binding;binding;catalytic activity;enzyme inhibitor activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein kinase inhibitor activity;protein serine/threonine kinase activity;purine nucleoside binding cell communication;intracellular signaling cascade;MAPKKK cascade;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein kinase cascade;protein modification process;response to stress;signal transduction MAPK signaling pathway 10 10 9 15.5 15.5 14 105.4 6.3508E-38 107340000 63156000 44179000 4669 IPI:IPI00410485.2 Serine/threonine-protein kinase TAO3;Thousand and one amino acid protein 3;Jun kinase-inhibitory kinase;JNK/SAPK-inhibitory kinase;Dendritic cell-derived protein kinase;Cutaneous T-cell lymphoma tumor antigen HD-CL-09;Kinase from chicken homolog A TAOK3;DPK;JIK;KDS;MAP3K18 Q9H2K8 ENST00000392533 K04429 1 NaN 1.3539 NaN NaN 0.89966 NaN 4 1 1 2.9 0.7 0.7 180.03 0.00031394 36573000 22599000 13974000 4670 IPI:IPI00410549.6;IPI:IPI00552057.5 Uncharacterized protein FLJ44048 Q6ZU21-1;Q6ZU21;Q6ZU21-2 ENST00000343098 2 NaN 0.38389 NaN NaN 0.25706 NaN AAA;LON;Lon_C ATP binding;ATP-dependent peptidase activity;binding;catalytic activity;endopeptidase activity;nucleoside binding;nucleotide binding;peptidase activity;protein binding;purine nucleoside binding;serine-type endopeptidase activity catabolic process;intracellular protein transport;macromolecule catabolic process;metabolic process;protein metabolic process;protein processing;protein targeting;protein targeting to peroxisome;protein transport;proteolysis;transport 2 2 2 2.2 2.2 2.2 94.615 0.00026202 14643000 6370500 8272500 4671 IPI:IPI00410584.4 Peroxisomal Lon protease homolog 2;Lon protease-like protein 2;Peroxisomal Lon protease LONP2;LONP Q86WA8 ENST00000285737 K01338 1 0.78053 1.7519 0.90801 1.1564 1.1356 1.2326 DFDF;FFD_TFG 3 3 3 9.1 9.1 9.1 50.553 6.0055E-06 94936000 47816000 47120000 4672 IPI:IPI00410590.5;IPI:IPI00478300.2 Protein LSM14 homolog A;Protein SCD6 homolog;Protein FAM61A;Putative alpha-synuclein-binding protein LSM14A;C19orf13;FAM61A Q8ND56-2;Q8ND56;Q8ND56-1 ENST00000324222;ENST00000356258 2 0.80196 1.2991 0.75859 1.0821 0.93998 0.91622 V-set cell part;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part binding;protein binding;structural molecule activity cell communication;cell surface receptor linked signal transduction;cell-cell signaling;cellular process;enzyme linked receptor protein signaling pathway;signal transduction;transmembrane receptor protein tyrosine kinase signaling pathway Cell adhesion molecules (CAMs) 3 3 3 16.3 16.3 16.3 22.761 3.0723E-11 44192000 21853000 22339000 4673 IPI:IPI00410607.4;IPI:IPI00022558.2;IPI:IPI00760547.1;IPI:IPI00644618.2 Myelin protein zero-like protein 1;Protein zero-related MPZL1;PZR;UNQ849/PRO1787 O95297-3;O95297;O95297-1;O95297-2 ENST00000359523;ENST00000392121 K06770 4 0.66717 1.5687 0.82458 0.94986 0.93854 1.162 2 2 2 17.5 17.5 17.5 17.465 3.2716E-15 53436000 28722000 24714000 4674 IPI:IPI00410618.4 Uncharacterized protein KIAA1143 KIAA1143 Q96AT1 ENST00000296121 1 0.7848 1.6706 0.79916 1.094 1.0213 1.0435 Pox_MCEL cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;catalytic activity;methyltransferase activity;mRNA (guanine-N7-)-methyltransferase activity;mRNA methyltransferase activity;N-methyltransferase activity;nucleic acid binding;RNA binding;RNA methyltransferase activity cellular process;metabolic process;mRNA capping;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA capping;RNA metabolic process;RNA processing 16 16 16 36.1 36.1 36.1 57.724 1.0384E-212 301820000 164290000 137530000 4675 IPI:IPI00410657.2;IPI:IPI00747403.20 mRNA cap guanine-N7 methyltransferase;mRNA (guanine-N(7)-)-methyltransferase;RG7MT1;mRNA cap methyltransferase RNMT;KIAA0398 O43148-2;O43148;O43148-1 ENST00000262173;ENST00000383314;ENST00000406931 K00565 2 0.97694 1.7662 1.0439 1.1927 1.2473 1.3109 Ank;zf-DHHC cell part;integral to membrane;intrinsic to membrane;membrane part acyltransferase activity;binding;catalytic activity;ion binding;signal transducer activity;transferase activity;transferase activity, transferring acyl groups;transferase activity, transferring acyl groups other than amino-acyl groups;zinc ion binding positive regulation of cell communication;positive regulation of protein kinase cascade;positive regulation of signal transduction;regulation of cell communication;regulation of protein kinase cascade;regulation of signal transduction 4 4 4 7.4 7.4 7.4 70.86 1.6085E-19 15469000 7877700 7591400 4676 IPI:IPI00410663.2;IPI:IPI00410665.1;IPI:IPI00410664.1 Probable palmitoyltransferase ZDHHC13;Zinc finger DHHC domain-containing protein 13;Huntingtin-interacting protein 14-related protein;Huntingtin-interacting protein HIP3RP;Putative MAPK-activating protein PM03;Putative NF-kappa-B-activating protein 209 ZDHHC13;HIP14L;HIP3RP Q8IUH4-1;Q8IUH4;Q8IUH4-3;Q8IUH4-2 ENST00000319776;ENST00000399351 3 NaN 0.5777 NaN NaN 0.41148 NaN LRR_1;PDZ cell part;cytoplasm;intracellular part;membrane binding;protein binding 3 3 3 2.2 2.2 2.2 177.69 4.1758E-07 8071100 4871900 3199200 4677 IPI:IPI00410666.2;IPI:IPI00425560.2;IPI:IPI00425562.6 Protein LAP4;Protein scribble homolog SCRIB;CRIB1;KIAA0147;LAP4;SCRB1;VARTUL Q14160-3;Q14160;Q14160-1;Q14160-2 ENST00000320476;ENST00000356994;ENST00000377533;ENST00000377539 3 0.92413 1.6911 0.88515 1.1657 1.1855 1.1421 Ank;zf-DHHC cytoplasmic part;cytoplasmic vesicle membrane;cytoplasmic vesicle part;Golgi apparatus part;Golgi membrane;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part;vesicle membrane acyltransferase activity;binding;catalytic activity;palmitoyltransferase activity;protein binding;S-acyltransferase activity;signal transducer activity;transferase activity;transferase activity, transferring acyl groups;zinc ion binding positive regulation of cell communication;positive regulation of protein kinase cascade;positive regulation of signal transduction;regulation of cell communication;regulation of protein kinase cascade;regulation of signal transduction;transport 2 2 2 3.3 3.3 3.3 72.639 0.00015343 5281500 2798500 2483000 4678 IPI:IPI00410687.11 Palmitoyltransferase ZDHHC17;Zinc finger DHHC domain-containing protein 17;Huntingtin-interacting protein 14;Huntingtin-interacting protein 3;Huntingtin-interacting protein H;Huntingtin yeast partner H;Putative MAPK-activating protein PM11;Putative NF-kappa-B-activating protein 205 ZDHHC17;HIP14;HIP3;HYPH;KIAA0946;HSPC294 Q8IUH5-1;Q8IUH5 ENST00000334822;ENST00000359019 1 0.70248 1.3412 0.76831 0.95357 0.90598 0.99257 HABP4_PAI-RBP1 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle;perinuclear region of cytoplasm binding;mRNA 3'-UTR binding;mRNA binding;nucleic acid binding;protein binding;RNA binding cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;posttranscriptional regulation of gene expression;regulation of gene expression;RNA metabolic process 17 17 17 42.2 42.2 42.2 44.965 0 3416900000 1745500000 1671400000 4679 IPI:IPI00410693.3;IPI:IPI00470497.3;IPI:IPI00470498.1;IPI:IPI00412714.3 Plasminogen activator inhibitor 1 RNA-binding protein;PAI1 RNA-binding protein 1;SERPINE1 mRNA-binding protein 1 SERBP1;PAIRBP1;CGI-55 Q8NC51-1;Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 ENST00000361219;ENST00000370990;ENST00000370994;ENST00000370995 4 0.67181 NaN 0.88316 0.89954 NaN 1.2464 Ras cell part;cytoplasm;intracellular part binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleotide binding;pyrophosphatase activity cell communication;cellular process;I-kappaB kinase/NF-kappaB cascade;intracellular signaling cascade;protein kinase cascade;regulation of biological process;regulation of cellular process;signal transduction;small GTPase mediated signal transduction 2 2 2 9.9 9.9 9.9 21.643 0.00020135 30866000 16664000 14202000 4680 IPI:IPI00410705.2 NF-kappa-B inhibitor-interacting Ras-like protein 1;I-kappa-B-interacting Ras-like protein 1 NKIRAS1;KBRAS1 Q9NYS0 ENST00000388759 1 0.66565 1.1936 0.5995 0.87591 0.76161 0.80186 CenpB-DNA-bind;DDE;zf-C2H2 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transition metal ion binding;zinc ion binding multicellular organismal development;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 13 13 13 12.1 12.1 12.1 155.34 6.1757E-134 107070000 55622000 51443000 4682 IPI:IPI00410717.2;IPI:IPI00410720.4;IPI:IPI00410719.2;IPI:IPI00514439.5;IPI:IPI00514078.1 Pogo transposable element with ZNF domain POGZ;KIAA0461;Nbla00003 Q7Z3K3-1;Q7Z3K3;Q7Z3K3-4;Q7Z3K3-3;Q7Z3K3-2;Q7Z3K3-5 ENST00000271715;ENST00000358476;ENST00000361398;ENST00000368863 5 0.2804 0.4758 0.2145 0.36091 0.32005 0.27103 AAA;PEX-1N;PEX-2N cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;microbody;microbody membrane;microbody part;organelle;organelle membrane;organelle part;peroxisomal membrane;peroxisomal part ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleoside binding;nucleotide binding;protein binding;protein C-terminus binding;purine nucleoside binding;pyrophosphatase activity cellular process;intracellular protein transport;microtubule-based process;peroxisomal transport;protein import;protein import into peroxisome matrix;protein targeting;protein targeting to peroxisome;protein transport;transport 5 5 5 3.7 3.7 3.7 142.87 4.9792E-11 4336000 2597500 1738500 4684 IPI:IPI00411291.1 Peroxisome biogenesis factor 1;Peroxin-1;Peroxisome biogenesis disorder protein 1 PEX1 O43933 ENST00000248633 1 0.75982 1.5185 0.81189 1.0491 1.0766 1.0781 AAA;MIT;Vps4_C cell part;cytoplasmic part;endosomal part;endosome membrane;intracellular organelle part;intracellular part;late endosome membrane;membrane;midbody;organelle membrane;organelle part;perinuclear region of cytoplasm ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleoside binding;nucleotide binding;protein binding;protein C-terminus binding;purine nucleoside binding;pyrophosphatase activity cell cycle;cell division;cellular process;cytokinesis;endosome transport;establishment of localization;establishment of protein localization;intracellular transport;protein transport;transport;vesicle-mediated transport 9 8 8 27.7 24.9 24.9 48.897 4.3509E-127 288250000 145300000 142960000 4685 IPI:IPI00411356.5 Vacuolar protein sorting-associated protein 4A;VPS4-1;Protein SKD2 VPS4A;VPS4 Q9UN37 ENST00000254950 K12196 1 0.98539 1.4971 0.94517 1.1976 1.0671 1.1951 Vps26 cell part;cytoplasmic part;cytosol;endosomal part;endosome membrane;intracellular organelle part;intracellular part;macromolecular complex;membrane;membrane part;organelle membrane;organelle part;protein complex;retromer complex binding;protein binding;protein transporter activity;substrate-specific transporter activity;transporter activity cellular process;endosome transport;establishment of localization;establishment of protein localization;intracellular transport;protein transport;retrograde transport, endosome to Golgi;transport;vacuolar transport;vesicle-mediated transport 10 10 9 39.1 39.1 37 38.169 1.2185E-132 332090000 175060000 157030000 4686 IPI:IPI00411426.3 Vacuolar protein sorting-associated protein 26A;Vesicle protein sorting 26A VPS26A;VPS26 O75436 ENST00000263559;ENST00000373382 1 0.68991 1.304 0.57477 0.9658 0.8714 0.79358 Adaptin_N;BLVR cell part;cytoplasmic part;Golgi apparatus part;Golgi membrane;intracellular organelle part;intracellular part;macromolecular complex;membrane;membrane coat;membrane part;organelle membrane;organelle part;protein complex binding;protein binding;protein transporter activity;substrate-specific transporter activity;transporter activity biosynthetic process;cellular process;eye pigment biosynthetic process;eye pigment metabolic process;intracellular protein transport;metabolic process;pigment metabolic process;protein transport;transport;vesicle-mediated transport 7 7 7 5.8 5.8 5.8 136.65 7.0039E-23 88938000 52518000 36420000 4687 IPI:IPI00719680.1;IPI:IPI00411453.3;IPI:IPI00411677.3;IPI:IPI00289608.4;IPI:IPI00413686.2 AP-3 complex subunit delta-1;Adapter-related protein complex 3 subunit delta-1;AP-3 complex subunit delta;Delta-adaptin AP3D1;PRO0039 O14617-5;O14617;O14617-1;O14617-4;O14617-2;O14617-3 ENST00000343722;ENST00000345016;ENST00000350812;ENST00000355272;ENST00000356926 K12396 5 0.53441 0.86325 0.52107 0.69004 0.6026 0.66922 Tau95 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex;transcription factor TFIIIC complex binding;DNA binding;nucleic acid binding;protein binding biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription;transcription from RNA polymerase III promoter;transcription, DNA-dependent 12 12 12 27.6 27.6 27.6 60.368 9.4241E-92 234100000 133560000 100550000 4688 IPI:IPI00879210.1;IPI:IPI00844182.1;IPI:IPI00411531.3 General transcription factor 3C polypeptide 5;Transcription factor IIIC subunit epsilon;TF3C-epsilon;TFIIIC 63 kDa subunit GTF3C5;CDABP0017 Q9Y5Q8-3;Q9Y5Q8;Q9Y5Q8-1;Q9Y5Q8-2 ENST00000372095;ENST00000372099;ENST00000372108 3 0.57798 1.1895 0.59056 0.77608 0.77085 0.80142 SMC_hinge;SMC_N chromosomal part;condensin complex;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;organelle part;protein complex adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cell cycle process;cell division;cellular component organization;cellular process;chromosome condensation;chromosome organization;DNA packaging;mitotic chromosome condensation;organelle organization Cell cycle - yeast 40 40 40 32.8 32.8 32.8 147.18 0 1214900000 689520000 525430000 4689 IPI:IPI00411559.2;IPI:IPI00328298.6 Structural maintenance of chromosomes protein 4;Chromosome-associated polypeptide C;XCAP-C homolog SMC4;CAPC;SMC4L1 Q9NTJ3-1;Q9NTJ3;Q9NTJ3-2 ENST00000344722;ENST00000357388;ENST00000360111 K06675 2 0.61026 0.99149 0.59389 0.80828 0.69 0.8001 WD40 cell part;cytoplasm;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;DNA binding;nucleic acid binding 17 17 17 18.2 18.2 18.2 125.97 2.3907E-111 208970000 109260000 99707000 4690 IPI:IPI00411614.1 WD repeat and HMG-box DNA-binding protein 1;Acidic nucleoplasmic DNA-binding protein 1 WDHD1;AND1 O75717 ENST00000360586 K11274 1 0.90757 1.6966 0.89665 1.1709 1.1349 1.1376 PCMT cell part;cytoplasmic part;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle binding;catalytic activity;methyltransferase activity;O-methyltransferase activity;protein binding;protein methyltransferase activity;protein-L-isoaspartate (D-aspartate) O-methyltransferase activity cellular biopolymer metabolic process;cellular process;metabolic process;methylation;one-carbon metabolic process;protein amino acid alkylation;protein amino acid methylation;protein metabolic process;protein modification process;protein repair 14 14 14 64.8 64.8 64.8 24.65 0 802140000 442560000 359570000 4691 IPI:IPI00411680.10;IPI:IPI00828189.2 Protein-L-isoaspartate(D-aspartate) O-methyltransferase;Protein-beta-aspartate methyltransferase;Protein L-isoaspartyl/D-aspartyl methyltransferase;L-isoaspartyl protein carboxyl methyltransferase PCMT1 P22061-1;P22061;P22061-2 ENST00000367378;ENST00000367380;ENST00000367384 K00573 2 0.68672 1.5532 0.75463 0.96261 0.96358 1.0227 eIF-5a annulate lamellae;cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;organelle part;pore complex;protein complex binding;nucleic acid binding;protein binding;protein N-terminus binding;RNA binding;snRNA binding;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity;U6 snRNA binding cellular amino acid and derivative metabolic process;mRNA export from nucleus;protein modification process;regulation of translation;regulation of translational initiation;RNA export from nucleus;translational initiation 17 17 17 69.6 69.6 69.6 20.17 0 6794500000 3606100000 3188400000 4692 IPI:IPI00376005.2;IPI:IPI00411704.9;IPI:IPI00855924.1;IPI:IPI00006935.3 Eukaryotic translation initiation factor 5A-1;Eukaryotic initiation factor 5A isoform 1;eIF-4D;Rev-binding factor;Eukaryotic translation initiation factor 5A-1-like;Eukaryotic initiation factor 5A isoform 1-like;Eukaryotic translation initiation factor 5A-2;Eukaryotic initiation factor 5A isoform 2 EIF5A;EIF5AL1;EIF5A2 P63241-2;P63241;P63241-1;Q6IS14;Q9GZV4 ENST00000336452;ENST00000336458;ENST00000295822 K03263 4 1.294 2.791 NaN 1.7508 1.8973 NaN SPRY 2 2 2 13.8 13.8 13.8 21.666 0.0021408 15079000 7893000 7185900 4693 IPI:IPI00411705.2;IPI:IPI00290764.5 Chronic lymphocytic leukemia deletion region gene 6 protein CLLD6;C13orf1 Q5W111-1;Q5W111;Q5W111-2 ENST00000361840;ENST00000378195 2 0.74863 1.502 0.76726 0.98529 1.002 0.99804 Esterase cell part;cytoplasmic membrane-bounded vesicle;cytoplasmic part;cytoplasmic vesicle;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;membrane-bounded vesicle;organelle;vesicle carboxylesterase activity;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;S-formylglutathione hydrolase activity;thiolester hydrolase activity 12 12 12 62.1 62.1 62.1 31.462 0 1905000000 1012400000 892610000 4694 IPI:IPI00411706.1 S-formylglutathione hydrolase;Esterase D ESD P10768 ENST00000378720 K03929 1 0.6572 1.1856 NaN 0.82476 0.78546 NaN HEAT cell fraction;cell part;soluble fraction binding;enzyme regulator activity;phosphatase regulator activity;protein binding;protein phosphatase regulator activity;protein phosphatase type 4 regulator activity biological regulation;cell communication;cellular process;regulation of biological process;regulation of cellular process;signal transduction 3 3 3 4.2 4.2 4.2 107 8.194E-44 9729300 5292700 4436500 4695 IPI:IPI00411730.5;IPI:IPI00478255.1 Serine/threonine-protein phosphatase 4 regulatory subunit 1 PPP4R1;MEG1;PP4R1 Q8TF05-1;Q8TF05;Q8TF05-2 ENST00000285124;ENST00000400556 2 0.73899 1.4411 0.69014 0.94862 0.99693 0.91348 DUF1605;HA2;Helicase_C cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial nucleoid;mitochondrial part;nucleoid;organelle part ATP binding;ATP-dependent helicase activity;binding;catalytic activity;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity;RNA binding 23 23 23 22.3 22.3 22.3 136.11 1.6549E-195 231770000 125950000 105820000 4696 IPI:IPI00926109.1;IPI:IPI00411733.4;IPI:IPI00477295.4 Putative ATP-dependent RNA helicase DHX30;DEAH box protein 30 DHX30;DDX30;KIAA0890 Q7L2E3-2;Q7L2E3;Q7L2E3-1;Q7L2E3-3 ENST00000328976;ENST00000348968 3 0.77316 1.3387 0.81953 0.98111 0.94047 1.0272 Ribosomal_L2;Ribosomal_L2_C intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;mitochondrion;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 9 9 9 40 40 40 33.3 1.0446E-76 62851000 33392000 29459000 4697 IPI:IPI00411816.3 39S ribosomal protein L2, mitochondrial;MRP-L2 MRPL2;CGI-22 Q5T653 ENST00000388752 1 0.53759 1.2126 0.55098 0.73357 0.78331 0.73865 Pkinase ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cellular biopolymer metabolic process;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process mTOR signaling pathway;Regulation of autophagy 13 13 13 34.1 34.1 34.1 53.444 9.6067E-146 103720000 51375000 52342000 4698 IPI:IPI00411818.4;IPI:IPI00944673.1 Serine/threonine-protein kinase ULK3;Unc-51-like kinase 3 ULK3 Q6PHR2-1;Q6PHR2 ENST00000268074 K08269 2 0.62071 1.3308 0.68452 0.82293 0.85495 0.84447 Noc2 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;protein binding 14 14 14 16.4 16.4 16.4 84.904 1.6254E-132 471480000 252500000 218980000 4699 IPI:IPI00411886.4 Nucleolar complex protein 2 homolog;NOC2-like NOC2L Q9Y3T9 ENST00000327044 1 0.68247 1.5097 0.7046 0.90987 0.97517 0.90691 Nop;NOP5NT;NOSIC cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;nucleic acid binding;RNA binding cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 28 28 28 55.7 55.7 55.7 66.049 0 3664600000 1939700000 1724900000 4700 IPI:IPI00411937.4 Nucleolar protein 56;Nucleolar protein 5A NOP56;NOL5A O00567 ENST00000329276 1 0.54458 0.99051 0.53873 0.68172 0.6756 0.68082 AMP-binding cell part;integral to membrane;intrinsic to membrane;membrane part binding;catalytic activity;fatty acid transporter activity;ligase activity;lipid transporter activity;nucleotide binding;protein binding;substrate-specific transporter activity;transporter activity carboxylic acid metabolic process;cellular process;fatty acid metabolic process;fatty acid transport;lipid metabolic process;lipid transport;metabolic process;monocarboxylic acid transport;organic acid metabolic process;organic acid transport;transport PPAR signaling pathway 7 7 7 11.8 11.8 11.8 72.063 8.381E-30 46497000 26375000 20122000 4702 IPI:IPI00412147.1 Long-chain fatty acid transport protein 4;Solute carrier family 27 member 4 SLC27A4;ACSVL4;FATP4 Q6P1M0 ENST00000300456 K08747 1 0.47787 1.0996 0.5074 0.66948 0.75066 0.67937 WD40 cell part;integral to membrane;intrinsic to membrane;membrane part 4 4 4 3.9 3.9 3.9 136.68 1.0037E-77 13711000 7561200 6149700 4703 IPI:IPI00412224.2 Bromodomain and WD repeat-containing protein 2;WD repeat-containing protein 11;WD repeat-containing protein 15 BRWD2;KIAA1351;WDR11;WDR15 Q9BZH6 ENST00000263461 1 0.75783 1.8117 NaN 1.1031 1.1105 NaN BolA 2 2 2 29 29 29 12.114 7.9864E-17 10488000 5461800 5026600 4704 IPI:IPI00412229.2 BolA-like protein 3 BOLA3 Q53S33 ENST00000327428 1 1.1657 NaN NaN 1.5396 NaN NaN TLD 2 2 2 6.4 6.4 6.4 51.032 3.6593E-39 440050 244190 195860 4705 IPI:IPI00412243.4 TLD domain-containing protein KIAA1609 KIAA1609 Q6P9B6 ENST00000343629 1 0.71888 1.1855 0.68958 0.90941 0.77026 0.91013 Pkinase cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;kinase activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity mRNA processing;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;RNA processing 16 16 13 29.3 29.3 24.9 74.324 2.9675E-159 418580000 225920000 192660000 4707 IPI:IPI00412344.6;IPI:IPI00936551.1;IPI:IPI00010067.4 Serine/threonine-protein kinase SRPK1;Serine/arginine-rich protein-specific kinase 1;SFRS protein kinase 1 SRPK1 Q96SB4-2;Q96SB4 ENST00000346162;ENST00000361690 K08831 3 0.78628 1.5845 0.72347 0.99278 1.0114 0.96816 Helicase_C cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;mitochondrial nucleoid;mitochondrial part;nucleoid;nucleus;organelle;organelle part ATP binding;binding;catalytic activity;DNA binding;DNA helicase activity;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity;RNA binding cellular biopolymer metabolic process;cellular process;DNA duplex unwinding;DNA geometric change;DNA metabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 12 12 12 21.8 21.8 21.8 87.99 1.3308E-129 148930000 81811000 67117000 4708 IPI:IPI00412404.1 ATP-dependent RNA helicase SUPV3L1, mitochondrial;SUV3-like protein 1;Suppressor of var1 3-like protein 1 SUPV3L1;SUV3 Q8IYB8 ENST00000359655 1 0.17166 NaN NaN 0.23626 NaN NaN BRCA2;BRCA-2_helical;BRCA-2_OB1;BRCA-2_OB3;Tower BRCA2-MAGE-D1 complex;centrosome;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;macromolecular complex;membrane-bounded organelle;membrane-bounded vesicle;microtubule organizing center;nucleoplasm;organelle;secretory granule;vesicle binding;cytoskeletal protein binding;DNA binding;gamma-tubulin binding;nucleic acid binding;protein binding;single-stranded DNA binding;structure-specific DNA binding;transcription activator activity;transcription regulator activity;tubulin binding cytokinesis;DNA metabolic process;DNA repair;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleotide-excision repair;regulation of transcription, DNA-dependent;response to stress Homologous recombination;Pancreatic cancer;Pathways in cancer 2 2 2 0.8 0.8 0.8 384.22 1.6045E-06 12773000 7384000 5389100 4709 IPI:IPI00412408.1 Breast cancer type 2 susceptibility protein;Fanconi anemia group D1 protein BRCA2;FACD;FANCD1 P51587 ENST00000380152 K08775 1 0.93124 1.9791 0.84059 1.2016 1.346 1.0935 Rab5-bind;Rabaptin cell part;cytoplasmic part;early endosome;endosome;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle binding;enzyme activator activity;enzyme regulator activity;growth factor activity;GTPase activator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity;protein binding;receptor binding cellular component organization;cellular process;endocytosis;establishment of localization;establishment of protein localization;membrane invagination;membrane organization;protein transport;transport;vesicle-mediated transport 6 6 6 12.8 12.8 12.8 63.542 1.2849E-37 49147000 29525000 19622000 4710 IPI:IPI00412499.1;IPI:IPI00412500.1 Rab GTPase-binding effector protein 2;Rabaptin-5beta RABEP2;RABPT5B Q9H5N1-1;Q9H5N1;Q9H5N1-2 ENST00000357573;ENST00000358201 2 0.66278 1.4826 0.68077 0.91369 0.90825 0.89433 Ribosomal_L1 cell part;cytoplasmic part;cytosol;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome binding;nucleic acid binding;RNA binding;structural constituent of ribosome;structural molecule activity anatomical structure morphogenesis;biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA processing;translational elongation Ribosome 15 15 15 54.4 54.4 54.4 24.831 2.6692E-294 5286000000 2808800000 2477200000 4711 IPI:IPI00412579.6 60S ribosomal protein L10a;CSA-19;Neural precursor cell expressed developmentally down-regulated protein 6 RPL10A;NEDD6 P62906 ENST00000322203;ENST00000361957 K02865 1 0.74786 1.4565 NaN 0.96216 1.0384 NaN Abhydrolase_1 extracellular region catalytic activity;hydrolase activity 3 3 3 10.9 10.9 10.9 32.823 6.4127E-27 27830000 7994000 19836000 4712 IPI:IPI00643071.2;IPI:IPI00412592.5 Abhydrolase domain-containing protein FAM108B1 FAM108B1;C9orf77;CGI-67 Q5VST6-2;Q5VST6;Q5VST6-1 ENST00000333421;ENST00000377041 2 0.67607 1.3085 0.87093 0.94646 0.86988 1.1344 Ribosomal_L29 cytosolic large ribosomal subunit;intracellular non-membrane-bounded organelle;intracellular organelle;large ribosomal subunit;macromolecular complex;non-membrane-bounded organelle;nucleolus;organelle;ribonucleoprotein complex;ribosomal subunit binding;mRNA binding;nucleic acid binding;protein binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 5 5 5 29.3 29.3 29.3 14.551 5.3476E-28 2839000000 1468000000 1371000000 4713 IPI:IPI00412607.6 60S ribosomal protein L35 RPL35 P42766 ENST00000348462 K02918 1 NaN 0.4957 0.26097 NaN 0.34216 0.33803 SPRY;zf-B_box;zf-C3HC4 cell fraction;cytoplasm;insoluble fraction;integral to membrane;integral to plasma membrane;intracellular part;intrinsic to membrane;intrinsic to plasma membrane;membrane;membrane fraction;nuclear membrane;nucleoplasm;organelle membrane;organelle part binding;catalytic activity;DNA binding;nucleic acid binding;protein kinase activity;protein tyrosine kinase activity;receptor activity;signal transducer activity;transmembrane receptor activity;transmembrane receptor protein tyrosine kinase activity negative regulation of transcription from RNA polymerase II promoter;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 4 4 4 10.5 10.5 10.5 58.489 3.8975E-20 19870000 11556000 8313500 4714 IPI:IPI00426252.1;IPI:IPI00412657.2 Zinc finger protein RFP;Ret finger protein;Tripartite motif-containing protein 27;RING finger protein 76 TRIM27;RFP;RNF76 P14373-1;P14373;P14373-2 ENST00000266119;ENST00000377194;ENST00000377199;ENST00000400720 K12009 2 0.92058 1.8238 0.95122 1.1342 1.2391 1.1594 Bac_surface_Ag cell fraction;insoluble fraction;integral to membrane;integral to membrane of membrane fraction;intrinsic to membrane;macromolecular complex;membrane fraction;mitochondrial sorting and assembly machinery complex;organelle part;protein complex anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex assembly;cellular macromolecular complex subunit organization;cellular process;protein complex assembly 18 18 18 37.7 37.7 37.7 51.976 1.9308E-136 491900000 247170000 244730000 4716 IPI:IPI00412713.4 Sorting and assembly machinery component 50 homolog SAMM50;CGI-51 Q9Y512 ENST00000350028;ENST00000396202 1 0.69685 1.5822 0.5857 0.86857 1.0993 0.71078 Mtc cell part;cytoplasmic part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial membrane;mitochondrial part;organelle membrane;organelle part binding;cation transmembrane transporter activity;ion transmembrane transporter activity;iron ion binding;substrate-specific transmembrane transporter activity;substrate-specific transporter activity;transmembrane transporter activity;transporter activity cation transport;di-, tri-valent inorganic cation transport;establishment of localization;ion transport;iron ion transport;metal ion transport;transition metal ion transport;transport 4 4 2 14.8 14.8 8 37.998 6.0309E-09 30458000 16403000 14054000 4717 IPI:IPI00412741.1;IPI:IPI00743741.3 Sideroflexin-4;Breast cancer resistance marker 1 SFXN4;BCRM1 Q6P4A7-1;Q6P4A7;Q6P4A7-2 ENST00000330036;ENST00000355697 2 0.95833 1.8787 0.92677 1.31 1.1583 1.2758 SH3_1 cell projection;filamentous actin;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane;non-membrane-bounded organelle;nucleolus;organelle;organelle part;plasma membrane;protein complex;ruffle binding;protein binding;protein domain specific binding;SH3 domain binding;structural constituent of cytoskeleton;structural molecule activity anatomical structure formation;cell communication;cellular component organization;cellular process;mitosis;nuclear division;organelle organization;protein complex assembly;signal transduction;substrate-bound cell migration, cell extension 11 11 11 20.7 20.7 20.7 71.45 2.9579E-32 214140000 110870000 103270000 4718 IPI:IPI00412771.1 CD2-associated protein;Cas ligand with multiple SH3 domains;Adapter protein CMS CD2AP Q9Y5K6 ENST00000359314;ENST00000371229 1 NaN 1.5138 0.89682 NaN 1.0731 1.0461 NAC 2 2 2 22.2 22.2 22.2 17.27 1.15E-05 88842000 45523000 43319000 4719 IPI:IPI00412792.2 Transcription factor BTF3 homolog 4;Basic transcription factor 3-like 4 BTF3L4 Q96K17 ENST00000313334;ENST00000371599;ENST00000405560 1 0.64659 1.1839 0.63494 0.84895 0.77813 0.84253 PrmA cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;methyltransferase activity;N-methyltransferase activity;protein binding;protein methyltransferase activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding chromatin organization;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;one-carbon metabolic process;protein amino acid methylation;protein modification process;regulation of transcription, DNA-dependent;transcription 16 16 16 28.4 28.4 28.4 63.459 3.3069E-154 363200000 197800000 165390000 4721 IPI:IPI00412880.2;IPI:IPI00514607.1 Histone-arginine methyltransferase CARM1;Protein arginine N-methyltransferase 4;Coactivator-associated arginine methyltransferase 1 CARM1;PRMT4 Q86X55-1;Q86X55;Q86X55-2 ENST00000327064;ENST00000344150 2 0.94956 1.6013 0.84246 1.2013 1.1016 1.1226 Cofilin_ADF cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;nucleus;organelle actin binding;binding;cytoskeletal protein binding;enzyme activator activity;enzyme inhibitor activity;growth factor activity;kinase regulator activity;protein binding;protein kinase inhibitor activity;receptor binding;signal transducer activity cell communication;cellular process;metabolic process;nervous system development;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein modification process;signal transduction 4 3 3 18.8 18.8 18.8 18.11 3.5798E-14 170610000 91315000 79299000 4722 IPI:IPI00412987.10 Glia maturation factor beta GMFB P60983 ENST00000354747;ENST00000358056;ENST00000401663 1 0.53474 1.8694 0.50646 0.70639 1.179 0.651 SMC_N cell part;chromosome;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cellular process;DNA metabolic process;DNA recombination;DNA repair;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to DNA damage stimulus;response to stress 4 4 4 4.1 4.1 4.1 128.81 4.787E-16 21945000 14008000 7937200 4725 IPI:IPI00413265.4 Structural maintenance of chromosomes protein 5 SMC5;KIAA0594;SMC5L1 Q8IY18 ENST00000361138 1 NaN 1.3701 NaN NaN 0.86463 NaN TLE_N;WD40 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding;transcription factor binding cell communication;cell surface receptor linked signal transduction;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;signal transduction;transcription 6 3 3 9.6 5.7 5.7 83.2 4.5308E-16 3431000 1780900 1650100 4726 IPI:IPI00413270.1;IPI:IPI00446767.2;IPI:IPI00749371.1;IPI:IPI00877770.1 Transducin-like enhancer protein 1;Enhancer of split groucho-like protein 1;E(Sp1) homolog;Transducin-like enhancer protein 4 TLE1;TLE4;KIAA1261 Q04724;Q04727-3;Q04727;Q04727-1;Q04727-2 ENST00000355002;ENST00000376499;ENST00000376527;ENST00000376537;ENST00000376544 4 0.67776 1.4422 0.6775 0.93947 0.90299 0.91342 Ribosomal_L22 cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;large ribosomal subunit;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 15 15 15 61.4 61.4 61.4 21.397 0 5041600000 2707300000 2334300000 4727 IPI:IPI00413324.6 60S ribosomal protein L17;60S ribosomal protein L23;PD-1 RPL17 P18621 ENST00000391360 K02880 1 NaN 1.7469 NaN NaN 1.2464 NaN CHCH cell part;cytoplasmic part;cytosol;intracellular part 2 2 2 25.6 25.6 25.6 10.394 7.0963E-05 1274600 728800 545840 4728 IPI:IPI00413436.2 Cytochrome c oxidase assembly protein COX19 COX19 Q49B96 ENST00000344111 1 0.84557 1.5708 NaN 1.1341 1.0074 NaN HCaRG cell part;cytoplasm;intracellular part binding;protein binding 7 7 7 48.7 48.7 48.7 21.764 3.8985E-94 48151000 26469000 21682000 4729 IPI:IPI00413500.4;IPI:IPI00456702.3 COMM domain-containing protein 4 COMMD4 Q9H0A8-1;Q9H0A8 ENST00000267935;ENST00000338995 2 0.73129 1.4426 0.81967 0.95484 0.98496 1.0316 BID cell fraction;cytoplasmic part;cytosol;insoluble fraction;intracellular part;membrane;membrane fraction;mitochondrial membrane;mitochondrial outer membrane;mitochondrial part;organelle membrane;organelle outer membrane;organelle part;outer membrane binding;cytokine receptor binding;death receptor binding;protein binding;receptor binding;tumor necrosis factor receptor superfamily binding apoptosis;cell death;induction of apoptosis;induction of apoptosis by extracellular signals;induction of apoptosis via death domain receptors;mitochondrion organization;organelle organization;release of cytochrome c from mitochondria Alzheimer's disease;Amyotrophic lateral sclerosis (ALS);Apoptosis;Natural killer cell mediated cytotoxicity;p53 signaling pathway;Pathways in cancer 7 7 6 38.2 38.2 26.6 26.836 2.8715E-123 509850000 256180000 253670000 4730 IPI:IPI00420084.3;IPI:IPI00413587.2;IPI:IPI00472003.1 BH3-interacting domain death agonist;p22 BID;BH3-interacting domain death agonist p15;p15 BID;BH3-interacting domain death agonist p13;p13 BID;BH3-interacting domain death agonist p11;p11 BID BID P55957-2;P55957;P55957-1 ENST00000317361;ENST00000337587;ENST00000344090;ENST00000399761;ENST00000399767;ENST00000399774 K04726 3 0.78706 1.5458 0.7915 1.005 1.0124 1.0347 Topoisom_I;Topoisom_I_N cell part;chromosome;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;nucleoplasm;organelle;organelle part binding;catalytic activity;chromatin binding;DNA binding;DNA topoisomerase (ATP-hydrolyzing) activity;DNA topoisomerase activity;DNA topoisomerase type I activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding cell death;DNA metabolic process;DNA unwinding during replication;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;phosphate metabolic process;phosphorus metabolic process 25 25 25 37.9 37.9 37.9 90.725 0 2860200000 1648700000 1211500000 4731 IPI:IPI00413611.1;IPI:IPI00465141.2 DNA topoisomerase 1;DNA topoisomerase I TOP1 P11387 ENST00000361337;ENST00000404238 K03163 2 0.89938 1.7497 0.91014 1.1932 1.1704 1.1598 Aldo_ket_red cell part;cytoplasmic part;cytosol;extracellular region part;extracellular space;intracellular part aldehyde reductase activity;aldo-keto reductase activity;binding;catalytic activity;electron carrier activity;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;protein binding carbohydrate metabolic process;metabolic process;oxidation reduction;primary metabolic process;response to stimulus;response to stress Fructose and mannose metabolism;Galactose metabolism;Glycerolipid metabolism;Pentose and glucuronate interconversions;Pyruvate metabolism 12 12 12 44.6 44.6 44.6 35.853 2.4378E-90 1687300000 918640000 768610000 4732 IPI:IPI00413641.7 Aldose reductase;Aldehyde reductase AKR1B1;ALDR1 P15121 ENST00000285930 K00011 1 0.54319 1.1074 0.54907 0.7456 0.7226 0.76587 cell part;integral to membrane;intrinsic to membrane;membrane part 4 4 4 14.4 14.4 14.4 51.409 3.1549E-103 77652000 42410000 35242000 4733 IPI:IPI00759562.1;IPI:IPI00413659.4 Alkylated DNA repair protein alkB homolog 5 ALKBH5;OFOXD1 Q6P6C2-1;Q6P6C2;Q6P6C2-2 ENST00000261650;ENST00000399138 K10767 2 0.86118 1.5158 NaN 1.1511 1.0794 NaN TAF4;TAFH cytoplasm;histone acetyltransferase complex;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex;transcription factor complex;transcription factor TFIID complex;transcription factor TFTC complex binding;DNA binding;nucleic acid binding;protein binding;RNA polymerase II transcription factor activity;transcription coactivator activity;transcription cofactor activity;transcription factor activity;transcription factor binding cellular process;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of transcription, DNA-dependent;transcription initiation;transcription initiation from RNA polymerase II promoter Basal transcription factors;Huntington's disease 2 2 2 2.7 2.7 2.7 110.11 4.0076E-26 3675800 1933900 1741900 4734 IPI:IPI00413755.1 Transcription initiation factor TFIID subunit 4;TBP-associated factor 4;Transcription initiation factor TFIID 135 kDa subunit;TAFII-130;RNA polymerase II TBP-associated factor subunit C TAF4;TAF2C;TAF2C1;TAF4A;TAFII130;TAFII135 O00268 ENST00000252996 K03129 1 1.0383 1.7196 0.93544 1.285 1.1751 1.1541 cell part;cytoplasmic part;Golgi apparatus part;Golgi cisterna membrane;Golgi membrane;intracellular organelle part;intracellular part;membrane;organelle membrane;organelle part binding;protein binding 4 3 3 4.3 3.3 3.3 113.08 1.6386E-09 2190300 1145900 1044400 4735 IPI:IPI00413895.2;IPI:IPI00943357.1;IPI:IPI00217605.2 Golgin subfamily A member 2;Cis-Golgi matrix protein GM130;Gm130 autoantigen;Golgin-95 GOLGA2 Q08379-2;Q08379;Q08379-1 ENST00000342583 3 NaN 0.066277 0.85083 NaN 0.048009 1.0228 SPRY;zf-B_box;zf-C3HC4 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding 2 2 2 3.5 3.5 3.5 71.669 5.0852E-33 83196000 30498000 52698000 4736 IPI:IPI00414021.2;IPI:IPI00414022.2;IPI:IPI00514646.2;IPI:IPI00909892.2 Tripartite motif-containing protein 41 TRIM41 Q8WV44-1;Q8WV44;Q8WV44-2;Q8WV44-4;Q8WV44-3 ENST00000315073;ENST00000351937 K12017 4 0.62635 1.5629 0.72226 0.86321 0.9753 0.96588 Ran_BP1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;enzyme activator activity;enzyme binding;enzyme regulator activity;GDP-dissociation inhibitor activity;GTPase activator activity;GTPase regulator activity;protein binding;Ran GTPase binding;Ras GTPase binding;small GTPase regulator activity biological regulation;cell communication;cellular process;establishment of localization;establishment of localization in cell;intracellular transport;regulation of biological process;regulation of cellular process;signal transduction;transport 10 10 10 47.8 47.8 47.8 23.31 0 2535100000 1373800000 1161200000 4737 IPI:IPI00414127.3 Ran-specific GTPase-activating protein;Ran-binding protein 1 RANBP1 P43487 ENST00000331821 1 0.72357 1.4982 0.74964 0.94805 0.98482 0.9742 zf-C3HC4 cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial membrane;mitochondrial outer membrane;mitochondrial part;organelle membrane;organelle outer membrane;organelle part;outer membrane binding;catalytic activity;cation binding;ion binding;ligase activity;metal ion binding;transition metal ion binding;zinc ion binding catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 4 4 4 19.8 19.8 19.8 31.231 2.7813E-104 89182000 48960000 40222000 4738 IPI:IPI00414168.1 E3 ubiquitin-protein ligase MARCH5;Membrane-associated RING finger protein 5;Membrane-associated RING-CH protein V;RING finger protein 153 MARCH5;RNF153 Q9NX47 ENST00000358935 K10660 1 0.83873 1.4476 1.1526 1.0411 0.93433 1.5437 RA cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding cell communication;cell cycle;cellular process;negative regulation of biological process;negative regulation of cell cycle;negative regulation of cellular process;regulation of biological process;regulation of cellular process;signal transduction 6 6 6 23.3 23.3 23.3 37.79 3.5543E-47 29528000 15418000 14110000 4739 IPI:IPI00414179.1;IPI:IPI00386527.3;IPI:IPI00644261.2;IPI:IPI00760676.1 Ras association domain-containing protein 2 RASSF2;KIAA0168 P50749 ENST00000379376;ENST00000379400 K09851 4 0.92513 1.7695 1.0329 1.1635 1.2435 1.4027 WD40 cell part;cytoplasm;intracellular part 6 6 6 12.3 12.3 12.3 72.123 7.7719E-92 23291000 14012000 9278500 4740 IPI:IPI00414197.3;IPI:IPI00645819.3 WD repeat-containing protein 26;CUL4- and DDB1-associated WDR protein 2;Myocardial ischemic preconditioning up-regulated protein 2 WDR26;CDW2;MIP2;PRO0852 Q9H7D7-1;Q9H7D7;Q9H7D7-2 ENST00000295024;ENST00000366852 2 0.84274 1.5757 0.73008 1.0548 1.0406 0.94653 GalKase_gal_bdg;GHMP_kinases_C;GHMP_kinases_N cell part;cytoplasm;intracellular part ATP binding;binding;catalytic activity;galactokinase activity;kinase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups alcohol metabolic process;carbohydrate metabolic process;cellular process;galactose metabolic process;hexose metabolic process;metabolic process;monosaccharide metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation 8 8 8 24.7 24.7 24.7 50.378 1.684E-207 99318000 54503000 44816000 4741 IPI:IPI00414287.1 N-acetylgalactosamine kinase;GalNAc kinase;Galactokinase 2 GALK2;GK2 Q01415 ENST00000327171;ENST00000396509 1 0.94799 1.7985 0.97833 1.2449 1.1568 1.242 Annexin cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;envelope;intracellular organelle;melanosome;membrane-bounded organelle;membrane-bounded vesicle;nuclear envelope;nucleoplasm;organelle;organelle envelope;vesicle binding;calcium ion binding;calcium-dependent phospholipid binding;calcium-dependent protein binding;cation binding;ion binding;lipid binding;metal ion binding;phospholipid binding;protein binding immune response;immune system process;response to stimulus 17 17 17 28.8 28.8 28.8 65.596 6.0975E-182 1182200000 594650000 587550000 4742 IPI:IPI00414320.2;IPI:IPI00465213.5;IPI:IPI00017337.7 Annexin A11;Annexin-11;Annexin XI;Calcyclin-associated annexin 50;56 kDa autoantigen ANXA11;ANX11 P50995 ENST00000265447;ENST00000360615;ENST00000372231;ENST00000372234 3 0.81387 1.8646 0.69699 1.1674 1.1045 0.90651 DUF625 centrosome;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;microtubule organizing center;non-membrane-bounded organelle;nucleus;organelle;organelle part binding;protein binding 7 4 4 11.8 7.7 7.7 97.443 1.0976E-123 6831600 3604100 3227500 4743 IPI:IPI00414323.5;IPI:IPI00551045.3;IPI:IPI00746325.2;IPI:IPI00795848.1 Serine/threonine-protein phosphatase 4 regulatory subunit 3B;SMEK homolog 2 SMEK2;KIAA1387;PP4R3B;PPP4R3B Q5MIZ7-1;Q5MIZ7;Q5MIZ7-2;Q5MIZ7-3 ENST00000272313;ENST00000345102 4 0.7052 1.7435 0.7223 0.98173 1.092 1.0671 Ribosomal_L22 intracellular membrane-bounded organelle;intracellular organelle;intracellular part;large ribosomal subunit;macromolecular complex;membrane-bounded organelle;mitochondrion;organelle;organelle part;ribonucleoprotein complex;ribosomal subunit structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 8 8 8 40.8 40.8 40.8 23.64 3.185E-54 95370000 51986000 43383000 4744 IPI:IPI00414410.2;IPI:IPI00556611.1 39S ribosomal protein L22, mitochondrial;MRP-L25 MRPL22;MRPL25;RPML25;HSPC158 Q9NWU5-1;Q9NWU5;Q9NWU5-2 ENST00000265229;ENST00000342738 2 0.89483 1.6888 0.9155 1.1857 1.1451 1.217 DUF773 binding;enzyme binding;kinase binding;neuronal Cdc2-like kinase binding;protein binding;protein kinase binding brain development;developmental process;regulation of cellular metabolic process;regulation of cyclin-dependent protein kinase activity;regulation of metabolic process;regulation of phosphate metabolic process;regulation of phosphorylation 12 12 12 22.6 22.6 22.6 59.586 1.551E-48 225220000 119880000 105340000 4745 IPI:IPI00414442.3;IPI:IPI00018780.1;IPI:IPI00187145.1 CDK5 regulatory subunit-associated protein 3;CDK5 activator-binding protein C53;Protein HSF-27 CDK5RAP3;IC53;MSTP016;OK/SW-cl.114;PP1553 Q96JB5-1;Q96JB5;Q96JB5-2;Q96JB5-3 ENST00000338399 3 0.74149 1.6745 1.0601 0.94672 1.1787 1.2904 LCM binding;catalytic activity;C-terminal protein carboxyl methyltransferase activity;methyltransferase activity;protein binding;protein methyltransferase activity;S-adenosylmethionine-dependent methyltransferase activity;transferase activity cellular process;C-terminal protein amino acid methylation;metabolic process;one-carbon metabolic process;peptide or protein carboxyl-terminal blocking;protein amino acid alkylation;protein amino acid methylation;protein modification process Aminophosphonate metabolism;Androgen and estrogen metabolism;Histidine metabolism;Naphthalene and anthracene degradation;Selenoamino acid metabolism;Tyrosine metabolism 8 8 8 19.3 19.3 19.3 41.105 1.1946E-40 95361000 41623000 53739000 4746 IPI:IPI00414463.3;IPI:IPI00872246.1 Leucine carboxyl methyltransferase 1;Protein-leucine O-methyltransferase LCMT1;LCMT;CGI-68 Q9UIC8-2;Q9UIC8;Q9UIC8-1 ENST00000380962;ENST00000399069 K00599 2 0.42494 0.82607 0.44465 0.56625 0.5322 0.56015 B-block_TFIIIC cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex;transcription factor TFIIIC complex binding;DNA binding;nucleic acid binding biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription;transcription from RNA polymerase III promoter;transcription, DNA-dependent 25 25 25 16.1 16.1 16.1 241.14 1.0192E-219 228610000 131300000 97315000 4747 IPI:IPI00414482.2;IPI:IPI00807491.2 General transcription factor 3C polypeptide 1;Transcription factor IIIC subunit alpha;TF3C-alpha;TFIIIC 220 kDa subunit;TFIIIC box B-binding subunit GTF3C1 Q12789-2;Q12789;Q12789-3 ENST00000170629;ENST00000356183 2 NaN 1.0786 0.74377 NaN 0.71861 0.90244 cell part;integral to membrane;intrinsic to membrane;membrane part 2 2 2 25.3 25.3 25.3 16.694 1.2403E-13 9681400 4632300 5049100 4748 IPI:IPI00414548.1 Uncharacterized protein C7orf44 C7orf44 Q9GZY4 ENST00000223336;ENST00000310564;ENST00000395879;ENST00000395880 1 0.94006 1.5968 0.90317 1.1229 0.94021 1.1162 GMP_PDE_delta 5 5 5 25.5 25.5 25.5 28.136 5.8552E-15 46222000 25149000 21072000 4750 IPI:IPI00414629.2;IPI:IPI00013262.1;IPI:IPI00220005.1 Protein unc-119 homolog B UNC119B A6NIH7 ENST00000344651 3 0.42107 1.1512 NaN 0.60694 0.79824 NaN AAA cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;DNA binding;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity biosynthetic process;cell cycle;cellular process;DNA metabolic process;DNA replication;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 8 7 7 10.4 9.7 9.7 110.21 5.1766E-35 8260600 4497300 3763400 4751 IPI:IPI00414657.4;IPI:IPI00872454.1;IPI:IPI00895945.1 Chromosome transmission fidelity protein 18 homolog CHTF18;CTF18 Q8WVB6-2;Q8WVB6;Q8WVB6-1;Q8WVB6-3 ENST00000262315;ENST00000317063 K11269 3 1.2244 2.3377 1.251 1.6442 1.512 1.6352 HATPase_c;HSP90 cell part;cytoplasmic membrane-bounded vesicle;cytoplasmic part;cytoplasmic vesicle;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;melanosome;membrane-bounded organelle;membrane-bounded vesicle;organelle;vesicle adenyl nucleotide binding;ATP binding;binding;enzyme regulator activity;nitric-oxide synthase regulator activity;nucleoside binding;nucleotide binding;protein binding;protein domain specific binding;purine nucleoside binding;purine nucleotide binding metabolic process;positive regulation of biosynthetic process;protein folding;regulation of biosynthetic process;regulation of cytokine-mediated signaling pathway;response to biotic stimulus;response to stress;response to unfolded protein Antigen processing and presentation;Pathways in cancer;Progesterone-mediated oocyte maturation;Prostate cancer 69 46 41 64.9 48.3 45.3 83.263 0 32954000000 16263000000 16691000000 4752 IPI:IPI00414676.6;IPI:IPI00555614.1;IPI:IPI00455599.4 Heat shock protein HSP 90-beta;HSP 84;Putative heat shock protein HSP 90-beta-3;Heat shock protein 90-beta c HSP90AB1;HSP90B;HSPC2;HSPCB;HSP90AB3P;HSP90BC P08238;Q58FF7 ENST00000353801;ENST00000371554;ENST00000371646;ENST00000327934 K04079 3 NaN NaN 0.76115 NaN NaN 1.1087 RRM_1 cell part;cytoplasm;heterogeneous nuclear ribonucleoprotein complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;ribonucleoprotein complex;spliceosomal complex binding;DNA binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding;sequence-specific DNA binding;single-stranded DNA binding;single-stranded telomeric DNA binding;structure-specific DNA binding;telomeric DNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 28 1 1 72.1 2.6 2.6 36.006 0 9858300 4769400 5088900 4753 IPI:IPI00414696.1 Heterogeneous nuclear ribonucleoproteins A2/B1 HNRNPA2B1;HNRPA2B1 P22626-2;P22626 ENST00000354667;ENST00000356674;ENST00000360787 1 0.96718 1.9942 1.0924 1.3217 1.2557 1.41 Cys_rich_FGFR cell part;cytoplasmic part;Golgi apparatus part;Golgi membrane;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part binding;protein binding;receptor binding 26 26 26 24.9 24.9 24.9 137.22 0 664130000 325390000 338750000 4754 IPI:IPI00414717.1;IPI:IPI00641153.3 Golgi apparatus protein 1;Golgi sialoglycoprotein MG-160;E-selectin ligand 1;Cysteine-rich fibroblast growth factor receptor;CFR-1 GLG1;CFR1;ESL1;MG160 Q92896-2;Q92896;Q92896-1 ENST00000205061 2 0.54811 1.2495 NaN 0.73152 0.81467 NaN HIT cell part;chromatin;chromosomal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;nucleoplasm;organelle;organelle part catalytic activity;chromatin binding;damaged DNA binding;deoxyribonuclease activity;DNA binding;double-stranded DNA binding;double-stranded RNA binding;exodeoxyribonuclease activity;exonuclease activity;nuclease activity;nucleic acid binding;RNA binding DNA metabolic process;DNA repair;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to DNA damage stimulus;response to reactive oxygen species;response to stress;single strand break repair 4 4 4 12.9 12.9 12.9 40.74 6.1535E-27 13811000 6723000 7088100 4755 IPI:IPI00420029.1;IPI:IPI00414767.1;IPI:IPI00554783.4;IPI:IPI00420030.1;IPI:IPI00420033.1;IPI:IPI00411460.1;IPI:IPI00420031.1;IPI:IPI00375305.1 Aprataxin;Forkhead-associated domain histidine triad-like protein APTX;AXA1 Q7Z2E3-1;Q7Z2E3;Q7Z2E3-7;Q7Z2E3-9;Q7Z2E3-3;Q7Z2E3-8;Q7Z2E3-10;Q7Z2E3-5 ENST00000309615;ENST00000344355;ENST00000379812;ENST00000379813;ENST00000379819 K10863 8 NaN 1.6727 NaN NaN 1.0524 NaN DEAD;DSHCT;Helicase_C cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;ATP-dependent RNA helicase activity;binding;catalytic activity;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;RNA binding;RNA helicase activity 3 3 3 3.7 3.7 3.7 137.8 2.2225E-29 3377600 2229900 1147700 4756 IPI:IPI00414819.2 Helicase SKI2W;Helicase-like protein SKIV2L;DDX13;SKI2W;SKIV2;W Q15477 ENST00000383336 1 0.79003 1.6001 0.82759 1.0574 1.0384 1.0574 Ank;SH3_1 cell part;cytoplasm;intracellular part binding;identical protein binding;protein binding biological regulation;cell communication;cellular process;developmental process;ossification;regulation of biological process;regulation of cellular process;signal transduction 8 8 8 45.8 45.8 45.8 23.787 5.5056E-78 467470000 238010000 229460000 4757 IPI:IPI00414836.6 Osteoclast-stimulating factor 1 OSTF1 Q92882 ENST00000346234;ENST00000407819 1 0.71573 2.1165 1.0243 0.93393 1.3551 1.3967 Sec34 cis-Golgi network;cytoplasmic part;Golgi apparatus part;Golgi cisterna membrane;Golgi membrane;Golgi transport complex;intracellular organelle part;intracellular part;macromolecular complex;membrane;organelle membrane;organelle part;protein complex protein transporter activity;substrate-specific transporter activity;transporter activity carbohydrate metabolic process;ER to Golgi vesicle-mediated transport;intracellular protein transport;protein amino acid glycosylation;protein modification process;retrograde vesicle-mediated transport, Golgi to ER;transport 3 3 3 3.7 3.7 3.7 94.095 4.7386E-46 7915300 4034400 3880900 4758 IPI:IPI00414858.3;IPI:IPI00555771.4 Conserved oligomeric Golgi complex subunit 3;Component of oligomeric Golgi complex 3;Vesicle-docking protein SEC34 homolog;p94 COG3;SEC34 Q96JB2-1;Q96JB2;Q96JB2-2 ENST00000349995 2 0.74902 1.3194 0.75113 1.0139 0.8869 0.9567 Ribosomal_L37ae cell part;cytoplasmic part;cytosol;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome binding;cation binding;ion binding;metal ion binding;protein binding;structural constituent of ribosome;structural molecule activity;transition metal ion binding;zinc ion binding biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 2 2 2 32.6 32.6 32.6 10.275 1.987E-90 1902200000 992010000 910180000 4759 IPI:IPI00414860.6 60S ribosomal protein L37a RPL37A P61513 ENST00000359681 K02921 1 0.73019 1.395 0.83263 0.95249 0.87754 1.0902 FAST_1;FAST_2;RAP ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups apoptosis;cell death;cellular process;death;programmed cell death 4 4 4 5.9 5.9 5.9 86.573 2.0374E-56 9196300 5469900 3726400 4760 IPI:IPI00414973.1 FAST kinase domain-containing protein 5 FASTKD5;KIAA1792 Q7L8L6 ENST00000380266 1 0.6598 1.2738 0.70841 0.86852 0.82661 0.93596 4 3 3 16.3 16.3 16.3 25.585 5.7825E-40 19859000 11237000 8622000 4761 IPI:IPI00414985.2 Uncharacterized protein C13orf27 C13orf27 Q5JUR7 ENST00000376032 1 0.77218 NaN NaN 1.0363 NaN NaN Ank;FERM_M cell part;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane;non-membrane-bounded organelle;organelle binding;enzyme regulator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity;protein binding;small GTPase regulator activity biological regulation;cell communication;cellular process;intracellular signaling cascade;regulation of biological process;regulation of cellular process;signal transduction;small GTPase mediated signal transduction 2 2 2 3 3 3 84.347 0.0010808 1549600 833620 715930 4762 IPI:IPI00418142.2 Krev interaction trapped protein 1;Cerebral cavernous malformations 1 protein KRIT1;CCM1 O00522-1;O00522 ENST00000340022;ENST00000394505;ENST00000394507 1 0.73328 1.6779 1.2435 0.96062 1.1074 1.5605 VPS9;zf-A20 cell part;cytoplasmic part;early endosome;endosome;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle;recycling endosome binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transition metal ion binding;zinc ion binding catabolic process;cellular component organization;cellular process;endocytosis;macromolecule catabolic process;membrane invagination;membrane organization;metabolic process;protein transport;proteolysis;transport;vesicle-mediated transport 2 2 2 3.2 3.2 3.2 79.37 2.8156E-12 34058000 16456000 17602000 4763 IPI:IPI00418213.1;IPI:IPI00816003.1;IPI:IPI00924641.1 Rab5 GDP/GTP exchange factor;Rabex-5;Rabaptin-5-associated exchange factor for Rab5;RAP1 RABGEF1;RABEX5 Q9UJ41-1;Q9UJ41;Q9UJ41-3;Q9UJ41-2 ENST00000284957;ENST00000380828 3 0.64315 2.0329 0.97064 0.91555 1.2425 1.3059 AT_hook;MBD cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;nucleus;organelle binding;DNA binding;double-stranded DNA binding;double-stranded methylated DNA binding;nucleic acid binding;protein binding;transcription cofactor activity;transcription corepressor activity;transcription factor binding;transcription repressor activity negative regulation of transcription from RNA polymerase II promoter;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 4 4 4 11.4 11.4 11.4 53.323 6.2523E-48 14330000 7705400 6624200 4764 IPI:IPI00645192.3;IPI:IPI00418234.4 Methyl-CpG-binding protein 2 MECP2 P51608-2;P51608;P51608-1 ENST00000303391;ENST00000369957;ENST00000369964 2 0.90777 1.6422 0.90415 1.1797 1.108 1.18 Glycolytic cell part;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle aldehyde-lyase activity;binding;carbon-carbon lyase activity;catalytic activity;cytoskeletal protein binding;fructose-bisphosphate aldolase activity;lyase activity;protein binding alcohol metabolic process;carbohydrate metabolic process;fructose metabolic process;generation of precursor metabolites and energy;glucose catabolic process;glucose metabolic process;glycolysis;metabolic process;monosaccharide metabolic process Carbon fixation in photosynthetic organisms;Fructose and mannose metabolism;Glycolysis / Gluconeogenesis;Pentose phosphate pathway 18 15 15 47.9 40.1 40.1 48.408 0 495210000 253860000 241350000 4766 IPI:IPI00418262.5 Fructose-bisphosphate aldolase C;Brain-type aldolase ALDOC;ALDC P09972 ENST00000226253;ENST00000395321 K01623 1 0.723 1.3359 0.74966 0.92233 0.91917 0.92169 Ribosomal_L14 intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;mitochondrion;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 5 5 5 26.2 26.2 26.2 15.947 3.5839E-32 75096000 45602000 29494000 4767 IPI:IPI00418290.1 39S ribosomal protein L14, mitochondrial;MRP-L32 MRPL14;MRPL32;RPML32 Q6P1L8 ENST00000372014 1 0.67197 1.5709 10.876 0.9558 1.1418 13.397 WH2 actin cytoskeleton;cell part;cytoplasmic part;cytoplasmic vesicle;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle;vesicle actin binding;binding;cytoskeletal protein binding;profilin binding;protein binding actin filament organization;actin polymerization or depolymerization;anatomical structure formation;cellular component assembly;cellular component organization;cellular process;cytoskeleton organization;organelle organization;protein complex assembly 3 3 3 9.4 9.4 9.4 51.996 1.8925E-22 74070000 13838000 60232000 4768 IPI:IPI00552369.1;IPI:IPI00418328.2;IPI:IPI00797331.2;IPI:IPI00952673.1 WAS/WASL-interacting protein family member 1;Wiskott-Aldrich syndrome protein-interacting protein;Protein PRPL-2 WIPF1;WASPIP;WIP O43516-3;O43516;O43516-1;O43516-2 ENST00000272746;ENST00000359761;ENST00000392546;ENST00000392547;ENST00000392548 4 0.65941 1.0351 0.59505 0.81046 0.74617 0.82511 DNA_mis_repair;HATPase_c;MutL_C cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;DNA binding;double-stranded DNA binding;endonuclease activity;hydrolase activity;nuclease activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding cell cycle;cellular process;DNA metabolic process;DNA repair;metabolic process;mismatch repair;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to DNA damage stimulus;response to stress Mismatch repair 4 4 4 6.4 6.4 6.4 95.797 4.9735E-17 7422200 3793300 3628900 4769 IPI:IPI00746337.1;IPI:IPI00418329.3;IPI:IPI00873034.1;IPI:IPI00874088.1 Mismatch repair endonuclease PMS2;PMS1 protein homolog 2;DNA mismatch repair protein PMS2 PMS2;PMSL2 P54278-1;P54278;P54278-3 ENST00000265849;ENST00000382321 K10858 4 0.71539 1.3192 0.61835 0.94257 0.8593 0.7578 DUF2356 cell part;integrator complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;protein binding cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;snRNA metabolic process;snRNA processing 11 11 11 15.8 15.8 15.8 118.07 1.3733E-160 58575000 31157000 27418000 4770 IPI:IPI00792312.1;IPI:IPI00418336.3;IPI:IPI00477093.3;IPI:IPI00645811.2 Integrator complex subunit 3 INTS3;C1orf193;C1orf60 Q68E01-1;Q68E01;Q68E01-2;Q68E01-3 ENST00000318967 4 NaN 1.6167 NaN NaN 0.99533 NaN GCFC cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;protein binding;transcription factor activity;transcription regulator activity biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 2 2 2 4.1 4.1 4.1 89.384 1.525E-05 900610 506660 393950 4771 IPI:IPI00418340.6;IPI:IPI00807475.1 GC-rich sequence DNA-binding factor;Transcription factor 9 TCF9;C2orf3 P16383-1;P16383;P16383-2 ENST00000321027 K09061 2 0.72836 1.4168 NaN 0.89654 1.0087 NaN Hydant_A_N;Hydantoinase_A;Hydantoinase_B ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;nucleoside binding;nucleotide binding;purine nucleoside binding Glutathione metabolism 2 2 2 3 3 3 137.46 0.0048443 4784500 2760000 2024500 4772 IPI:IPI00418382.1 5-oxoprolinase;5-oxo-L-prolinase;Pyroglutamase OPLAH O14841 ENST00000360660 K01469 1 0.68026 1.4889 0.66851 0.88482 0.95468 0.87685 Filament;Filament_head cell part;cytoplasm;cytoskeletal part;intermediate filament;intracellular organelle part;intracellular part;organelle part binding;protein binding;structural constituent of cytoskeleton;structural molecule activity cell motion;cellular process;interspecies interaction between organisms;multi-organism process 54 54 52 77.7 77.7 75.1 53.651 0 38675000000 20963000000 17712000000 4775 IPI:IPI00418471.6;IPI:IPI00465084.6;IPI:IPI00217507.6;IPI:IPI00793184.1;IPI:IPI00013164.4;IPI:IPI00237671.9 Vimentin VIM P08670 ENST00000224237 K07606 6 0.76 1.3127 0.76022 0.97675 0.91564 0.95672 NIF integral to membrane;intracellular part;intrinsic to membrane;macromolecular complex;membrane part;mitochondrial inner membrane presequence translocase complex;mitochondrial part;nuclear body;nuclear part;nuclear speck;organelle part;protein complex binding;catalytic activity;hydrolase activity;nucleic acid binding;phosphoprotein phosphatase activity;protein binding;protein serine/threonine phosphatase activity;protein tyrosine phosphatase activity;RNA binding intracellular protein transport;mitochondrial membrane organization;mitochondrion organization;organelle organization;phosphate metabolic process;phosphorus metabolic process;protein amino acid dephosphorylation;protein modification process;transport 10 10 10 26.5 26.5 26.5 50.464 1.0031E-149 327180000 174350000 152830000 4776 IPI:IPI00418497.1;IPI:IPI00656071.1 Mitochondrial import inner membrane translocase subunit TIM50 TIMM50;TIM50;PRO1512 Q3ZCQ8-2;Q3ZCQ8;Q3ZCQ8-1 ENST00000314349 2 0.95779 1.6099 1.0278 1.2702 1.0408 1.2594 UQ_con acid-amino acid ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleoside binding;nucleotide binding;purine nucleoside binding;ubiquitin-protein ligase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein metabolic process;protein modification process;proteolysis;regulation of metabolic process Ubiquitin mediated proteolysis 4 4 3 16.4 16.4 13 27.166 3.8145E-14 73480000 36617000 36862000 4777 IPI:IPI00418603.1 Ubiquitin-conjugating enzyme E2 R2;Ubiquitin-protein ligase R2;Ubiquitin carrier protein R2;E2-CDC34B UBE2R2;CDC34B;UBC3B Q712K3 ENST00000263228 K02207 1 1.0812 2.2225 1.3215 1.4815 1.4832 1.8062 Acyl-CoA_dh_1;Acyl-CoA_dh_M;Acyl-CoA_dh_N;APH;Hydrolase acyl-CoA dehydrogenase activity;binding;catalytic activity;electron carrier activity;hydrolase activity;nucleoside binding;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on the CH-CH group of donors;purine nucleoside binding metabolic process 3 3 3 3.9 3.9 3.9 118.83 4.0131E-65 348730 186380 162350 4778 IPI:IPI00418639.4;IPI:IPI00843833.1;IPI:IPI00797832.2;IPI:IPI00843880.1 Acyl-CoA dehydrogenase family member 10 ACAD10 Q6JQN1-1;Q6JQN1;Q6JQN1-2;Q6JQN1-3 ENST00000313698;ENST00000392636 4 0.77206 NaN NaN 0.9713 NaN NaN Metallophos cell part;integral to membrane;intrinsic to membrane;membrane part binding;catalytic activity;cation binding;hydrolase activity;ion binding;metal ion binding 2 2 2 5.5 5.5 5.5 49.452 1.8505E-06 5136400 2863800 2272600 4780 IPI:IPI00418754.3;IPI:IPI00885142.1 Transmembrane protein with metallophosphoesterase domain TMPPE Q6ZT21-1;Q6ZT21;Q6ZT21-2 ENST00000342462 2 0.80166 1.845 NaN 1.1117 1.2321 NaN Lipase_GDSL catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds catabolic process;lipid catabolic process;lipid metabolic process;metabolic process;primary metabolic process 4 4 4 27 27 27 27.598 2.8839E-34 15172000 8491000 6680800 4781 IPI:IPI00419194.2 Isoamyl acetate-hydrolyzing esterase 1 homolog IAH1 Q2TAA2 ENST00000351760 1 0.95091 1.8301 0.9378 1.2451 1.1952 1.2315 Peptidase_M17;Peptidase_M17_N aminopeptidase activity;binding;catalytic activity;cation binding;exopeptidase activity;hydrolase activity;ion binding;magnesium ion binding;manganese ion binding;metalloexopeptidase activity;metallopeptidase activity;peptidase activity;zinc ion binding biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis Arginine and proline metabolism;Glutathione metabolism 28 28 28 64.5 64.5 64.5 56.166 0 2732000000 1394500000 1337400000 4783 IPI:IPI00419237.3;IPI:IPI00789806.2 Cytosol aminopeptidase;Leucine aminopeptidase;Leucyl aminopeptidase;Leucine aminopeptidase 3;Proline aminopeptidase;Prolyl aminopeptidase;Peptidase S LAP3;LAPEP;PEPS P28838-1;P28838;P28838-2 ENST00000226299 K11142 2 0.60356 1.497 0.68234 0.902 0.94425 0.96715 HMG_box cell part;chromosome;condensed chromosome;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;nucleus;organelle;organelle part binding;DNA bending activity;DNA binding;nucleic acid binding;protein binding;transcription factor binding base-excision repair, DNA ligation;DNA ligation;DNA metabolic process;DNA unwinding during replication;negative regulation of transcription from RNA polymerase II promoter;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Base excision repair 22 22 16 52.1 52.1 35.8 24.893 0 10872000000 5811200000 5060500000 4784 IPI:IPI00419258.4;IPI:IPI00018755.1;IPI:IPI00022796.2 High mobility group protein B1;High mobility group protein 1;High mobility group protein 1-like 10;Putative high mobility group protein 1-like 1 HMGB1;HMG1;HMG1L10;HMG1L1 P09429;Q9UGV6;B2RPK0 ENST00000339872;ENST00000341423;ENST00000399494;ENST00000405805;ENST00000243919 K10802 3 0.84497 1.5291 0.73984 1.0677 1.0348 1.001 ACBP;ECH cell part;cytoplasmic part;intracellular organelle lumen;intracellular organelle part;intracellular part;membrane-enclosed lumen;microbody lumen;microbody part;organelle lumen;organelle part;peroxisomal matrix;peroxisomal part acyl-CoA binding;binding;catalytic activity;dodecenoyl-CoA delta-isomerase activity;fatty acid binding;intramolecular oxidoreductase activity;intramolecular oxidoreductase activity, transposing C=C bonds;isomerase activity;lipid binding carboxylic acid metabolic process;cellular ketone metabolic process;cellular process;fatty acid metabolic process;lipid metabolic process;metabolic process;monocarboxylic acid metabolic process;organic acid metabolic process;oxoacid metabolic process Fatty acid metabolism 19 19 19 51.8 51.8 51.8 43.585 3.406E-252 733490000 209410000 524080000 4785 IPI:IPI00639841.2;IPI:IPI00419263.4 Peroxisomal 3,2-trans-enoyl-CoA isomerase;Dodecenoyl-CoA isomerase;Delta(3),delta(2)-enoyl-CoA isomerase;DBI-related protein 1;DRS-1;Hepatocellular carcinoma-associated antigen 88;Renal carcinoma antigen NY-REN-1 PECI;DRS1;HCA88 O75521-1;O75521;O75521-2 ENST00000361538;ENST00000380118;ENST00000380125 K01825 2 0.46985 0.89927 0.50717 0.62515 0.60252 0.667 Cullin;Cullin_Nedd8 cell part;cullin-RING ubiquitin ligase complex;intracellular part;macromolecular complex;protein complex;ubiquitin ligase complex binding;enzyme binding;protein binding;ubiquitin protein ligase binding DNA metabolic process;DNA repair;G1/S transition of mitotic cell cycle;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Nucleotide excision repair;Ubiquitin mediated proteolysis 22 22 16 37.8 37.8 29.5 87.679 7.8494E-164 353870000 195090000 158790000 4786 IPI:IPI00419273.5;IPI:IPI00549919.1 Cullin-4A CUL4A Q13619-1;Q13619;Q13619-2 ENST00000375440;ENST00000375441 K10609 2 0.68023 1.6904 0.64062 0.94082 1.0695 0.92718 RRM_1 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 22 2 2 49.7 8.2 8.2 39.594 0 499950000 278310000 221640000 4787 IPI:IPI00419373.1 Heterogeneous nuclear ribonucleoprotein A3 HNRNPA3;HNRPA3 P51991-1;P51991 ENST00000392524 1 0.95586 1.7769 0.97399 1.2015 1.2199 1.2441 C2;RBD-FIP cytoplasmic vesicle membrane;endocytic vesicle membrane;endosome;intracellular membrane-bounded organelle;intracellular organelle;membrane;membrane-bounded organelle;organelle;organelle membrane;organelle part;phagocytic vesicle membrane;vesicle membrane binding;protein binding establishment of localization;establishment of protein localization;protein transport;transport 2 2 2 1.8 1.8 1.8 137.19 5.5133E-06 9894400 4707900 5186600 4788 IPI:IPI00419433.2;IPI:IPI00465151.1;IPI:IPI00335140.5;IPI:IPI00556406.1 Rab11 family-interacting protein 1;Rab-coupling protein RAB11FIP1;RCP Q6WKZ4-4;Q6WKZ4;Q6WKZ4-3;Q6WKZ4-1;Q6WKZ4-2 ENST00000287263;ENST00000330843;ENST00000343853 4 0.27714 0.40382 NaN 0.38144 0.26249 NaN SPRY;zf-B_box;zf-C3HC4 cell part;intracellular binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding 6 6 6 17.4 17.4 17.4 57.295 1.1384E-101 28234000 14765000 13469000 4789 IPI:IPI00419451.4 Tripartite motif-containing protein 65 TRIM65 Q6PJ69 ENST00000269383 K12031 1 NaN 1.6989 NaN NaN 0.92679 NaN NAC cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding;RNA polymerase II transcription factor activity;transcription regulator activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent 8 1 1 62.3 6.2 6.2 17.699 9.509E-213 2447000 668050 1778900 4790 IPI:IPI00419473.5;IPI:IPI00015945.1 Transcription factor BTF3;RNA polymerase B transcription factor 3 BTF3;NACB;OK/SW-cl.8 P20290-2;P20290 ENST00000335895;ENST00000380591 K01527 2 0.63809 1.0329 0.59041 0.81552 0.68899 0.73031 Lactamase_B;RMMBL cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;hydrolase activity;nucleic acid binding;protein binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 16 16 16 22.5 22.5 22.5 88.486 1.6308E-209 414840000 217890000 196950000 4791 IPI:IPI00419531.2 Cleavage and polyadenylation specificity factor subunit 2;Cleavage and polyadenylation specificity factor 100 kDa subunit CPSF2;CPSF100;KIAA1367 Q9P2I0 ENST00000298875 1 0.74212 1.6545 0.66341 1.0274 1.0284 0.88282 DUF410 binding;protein binding 2 2 2 8.2 8.2 8.2 36.603 1.8353E-48 84124000 21363000 62761000 4793 IPI:IPI00419575.6;IPI:IPI00893923.1 UPF0363 protein C7orf20;Conserved edge-expressed protein C7orf20;CEE;CGI-20 Q7L5D6-1;Q7L5D6;Q7L5D6-2 ENST00000265857 2 0.78936 1.3966 0.78425 0.99899 0.95721 1.0047 Pro_isomerase cell part;cytoplasmic part;cytosol;extracellular region;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;cis-trans isomerase activity;isomerase activity;peptide binding;peptidyl-prolyl cis-trans isomerase activity;protein binding;unfolded protein binding;virion binding cellular process;DNA integration;DNA metabolic process;DNA recombination;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein folding;provirus integration 16 16 16 87.3 87.3 87.3 18.012 0 29536000000 15300000000 14236000000 4795 IPI:IPI00419585.9;IPI:IPI00030144.1;IPI:IPI00657716.1 Peptidyl-prolyl cis-trans isomerase A;Cyclophilin A;Cyclosporin A-binding protein PPIA;CYPA P62937 ENST00000355968 K03767 3 0.8361 1.5119 0.81081 1.0997 0.97039 1.113 Mitoc_L55 cytoplasmic part;intracellular part;large ribosomal subunit;macromolecular complex;mitochondrial large ribosomal subunit;mitochondrial part;organellar large ribosomal subunit;organelle part;ribonucleoprotein complex;ribosomal subunit structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 3 3 3 24.4 24.4 24.4 18.902 3.5209E-43 76495000 41484000 35011000 4796 IPI:IPI00419626.2;IPI:IPI00640399.2 39S ribosomal protein L55, mitochondrial MRPL55;UNQ5835/PRO19675 Q7Z7F7-2;Q7Z7F7;Q7Z7F7-1 ENST00000295008;ENST00000336300;ENST00000336520;ENST00000348259;ENST00000366731;ENST00000366733;ENST00000366734;ENST00000366735;ENST00000366736;ENST00000366739;ENST00000366740;ENST00000366741;ENST00000366742;ENST00000366744;ENST00000366746;ENST00000366747;ENST00000391866;ENST00000391867 2 0.68607 2.0074 NaN 0.8652 1.3727 NaN SAM_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;identical protein binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transition metal ion binding;zinc ion binding developmental process;multicellular organismal development;multicellular organismal process 3 3 3 4.5 4.5 4.5 90.712 1.2296E-07 7006400 3831200 3175300 4797 IPI:IPI00943102.1;IPI:IPI00647439.2;IPI:IPI00419684.2;IPI:IPI00443448.3 Polyhomeotic-like protein 2;Early development regulatory protein 2 PHC2;EDR2;PH2 Q8IXK0-1;Q8IXK0;Q8IXK0-4;Q8IXK0-2;Q8IXK0-3 ENST00000257118;ENST00000361167;ENST00000373416 4 NaN 2.1879 0.94893 NaN 1.3692 1.3011 EGF_CA cell part;cytoplasmic part;endoplasmic reticulum;extracellular region;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle binding;calcium ion binding;cation binding;ion binding;metal ion binding 2 2 2 7 7 7 43.578 1.334E-10 28955000 11993000 16962000 4798 IPI:IPI00794252.1;IPI:IPI00796204.1;IPI:IPI00419731.4;IPI:IPI00794793.1;IPI:IPI00386754.4;IPI:IPI00797918.1 Cysteine-rich with EGF-like domain protein 2 CRELD2;UNQ185/PRO211 Q6UXH1-5;Q6UXH1;Q6UXH1-6;Q6UXH1-1;Q6UXH1-4;Q6UXH1-2;Q6UXH1-3 ENST00000328268;ENST00000404488 6 1.0442 1.7308 1.023 1.252 1.2256 1.2889 3 3 3 7.6 7.6 7.6 50.559 4.526E-29 92408000 46884000 45525000 4799 IPI:IPI00419791.3;IPI:IPI00848084.2 Arginine/serine-rich coiled-coil protein 2 RSRC2 Q7L4I2-1;Q7L4I2;Q7L4I2-2 ENST00000331738;ENST00000354654 2 1.2335 2.3679 1.3314 1.6436 1.5335 1.7046 ECH cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle 3-hydroxyisobutyryl-CoA hydrolase activity;binding;catalytic activity;CoA hydrolase activity;hydrolase activity;hydrolase activity, acting on ester bonds;protein binding;thiolester hydrolase activity catabolic process;cellular amino acid and derivative metabolic process;cellular amino acid catabolic process;cellular amino acid metabolic process;metabolic process;nitrogen compound metabolic process;organic acid metabolic process beta-Alanine metabolism;Propanoate metabolism;Valine, leucine and isoleucine degradation 19 19 19 51.6 51.6 51.6 43.482 1.3023E-163 420440000 208850000 211600000 4800 IPI:IPI00419802.4;IPI:IPI00377161.8 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial;3-hydroxyisobutyryl-coenzyme A hydrolase HIBCH Q6NVY1-1;Q6NVY1;Q6NVY1-2 ENST00000359678;ENST00000392332;ENST00000392333 K05605 2 0.72133 1.3561 0.72369 0.94954 0.92598 0.89672 UCH cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;cation binding;hydrolase activity;hydrolase activity, acting on ester bonds;ion binding;metal ion binding;protein binding;thiolester hydrolase activity;ubiquitin thiolesterase activity;zinc ion binding anatomical structure formation;catabolic process;cellular component organization;cellular process;macromolecule catabolic process;metabolic process;protein metabolic process;proteolysis;spliceosome assembly;ubiquitin-dependent protein catabolic process 15 15 15 34.3 34.3 34.3 65.38 2.5181E-256 625780000 343730000 282050000 4801 IPI:IPI00419844.3 U4/U6.U5 tri-snRNP-associated protein 2;U4/U6.U5 tri-snRNP-associated 65 kDa protein;Inactive ubiquitin-specific peptidase 39;SAD1 homolog USP39;CGI-21;HSPC332;PRO2855 Q53GS9 ENST00000323701;ENST00000409470 1 0.71275 1.3672 0.72183 0.90373 0.92075 0.94488 COX15-CtaA cell part;cytoplasmic part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane part;mitochondrial membrane part;mitochondrial part;mitochondrial respiratory chain;organelle part;respiratory chain catalytic activity;cation transmembrane transporter activity;cytochrome-c oxidase activity;heme-copper terminal oxidase activity;ion transmembrane transporter activity;monovalent inorganic cation transmembrane transporter activity;transporter activity generation of precursor metabolites and energy;heme a biosynthetic process;heme biosynthetic process;mitochondrial electron transport, cytochrome c to oxygen;porphyrin biosynthetic process;porphyrin metabolic process;protein complex assembly Oxidative phosphorylation;Porphyrin and chlorophyll metabolism;Two-component system 3 3 3 9 9 9 46.03 5.855E-13 53204000 26795000 26409000 4802 IPI:IPI00419869.1;IPI:IPI00455190.2 Cytochrome c oxidase assembly protein COX15 homolog COX15 Q7KZN9-1;Q7KZN9;Q7KZN9-2 ENST00000016171;ENST00000370483 K02259 2 0.68138 1.2847 0.69804 0.91925 0.88927 0.89999 Ribosomal_S3Ae cytosolic small ribosomal subunit;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nucleolus;organelle;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit binding;nucleic acid binding;protein binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular process;induction of apoptosis;macromolecule biosynthetic process;metabolic process;positive regulation of cell death;regulation of cell death;translational elongation;translational initiation Ribosome 26 26 26 68.6 68.6 68.6 29.945 0 10077000000 5436100000 4640600000 4803 IPI:IPI00419880.6 40S ribosomal protein S3a RPS3A;MFTL P61247 ENST00000274065 K02984 1 0.72851 1.3186 1.1446 0.95669 0.88678 1.7294 Ribosomal_L29e cell part;cytoplasmic part;cytosolic large ribosomal subunit;cytosolic part;intracellular organelle part;intracellular part;large ribosomal subunit;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit binding;carbohydrate binding;glycosaminoglycan binding;heparin binding;nucleic acid binding;pattern binding;polysaccharide binding;protein binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;developmental process;embryo implantation;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 3 3 3 22.6 22.6 22.6 17.752 4.4174E-27 1050600000 541510000 509090000 4804 IPI:IPI00419919.5 60S ribosomal protein L29;Cell surface heparin-binding protein HIP RPL29 P47914 ENST00000294189 K02905 1 NaN 0.54056 NaN NaN 0.38649 NaN IQ 2 2 2 2.9 2.9 2.9 77.297 0.0045224 2657600 1029200 1628500 4805 IPI:IPI00419922.2;IPI:IPI00843929.1;IPI:IPI00843879.1;IPI:IPI00844042.1 IQ domain-containing protein E IQCE;KIAA1023 Q6IPM2-1;Q6IPM2;Q6IPM2-4;Q6IPM2-3;Q6IPM2-2 ENST00000402050;ENST00000404984 4 1.4885 3.0053 1.1619 1.8363 2.1196 1.4432 Cation_ATPase_C;Cation_ATPase_N;E1-E2_ATPase;Hydrolase cell part;cytoplasmic part;Golgi apparatus part;Golgi membrane;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part;trans-Golgi network ATP binding;binding;calcium ion binding;calcium-transporting ATPase activity;catalytic activity;magnesium ion binding;nucleoside binding;nucleotide binding;purine nucleoside binding;signal transducer activity;transporter activity ATP biosynthetic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;transport 7 7 7 10.5 10.5 10.5 105.06 2.6111E-262 26410000 13155000 13255000 4806 IPI:IPI00745171.2;IPI:IPI00419957.2;IPI:IPI00607568.3;IPI:IPI00607812.1;IPI:IPI00413116.2;IPI:IPI00220473.2 Calcium-transporting ATPase type 2C member 1;ATP-dependent Ca(2+) pump PMR1 ATP2C1;KIAA1347;PMR1L;HUSSY-28 P98194-6;P98194;P98194-1;P98194-4;P98194-5;P98194-3;P98194-2 ENST00000328560;ENST00000347421;ENST00000359644;ENST00000393221 K01537 6 0.76904 1.5262 0.7712 1.0166 0.98049 0.99919 PBD;Pkinase cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;nucleus;organelle;perinuclear region of cytoplasm ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity apoptosis;cell communication;cell death;metabolic process;negative regulation of protein kinase activity;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;signal transduction Axon guidance;ErbB signaling pathway;Focal adhesion;MAPK signaling pathway;Regulation of actin cytoskeleton;Renal cell carcinoma;T cell receptor signaling pathway 29 29 19 62.5 62.5 45.3 58.075 0 2364800000 1243100000 1121700000 4807 IPI:IPI00419979.3 Serine/threonine-protein kinase PAK 2;p21-activated kinase 2;Gamma-PAK;PAK65;S6/H4 kinase;p58;PAK-2p27;PAK-2p34;C-t-PAK2 PAK2 Q13177 ENST00000327134 K04410 1 0.60207 1.2563 0.61224 0.75369 0.86803 0.75695 Myosin_head;Myosin_TH1 cell part;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;myosin complex;organelle part;protein complex actin binding;ATP binding;binding;calmodulin binding;catalytic activity;cytoskeletal protein binding;hydrolase activity;motor activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity 36 36 21 45.8 45.8 23.8 116.44 0 2051800000 1140500000 911360000 4808 IPI:IPI00420004.3;IPI:IPI00895957.1;IPI:IPI00895790.1 Myosin-Ig;Minor histocompatibility antigen HA-2 MYO1G B0I1T2-1;B0I1T2;B0I1T2-4 ENST00000258787 K10356 3 0.65611 1.2526 0.62955 0.85237 0.84082 0.83084 DEAD;Helicase_C;Sec63 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;small nuclear ribonucleoprotein complex;U5 snRNP ATP binding;ATP-dependent helicase activity;binding;catalytic activity;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;cis assembly of pre-catalytic spliceosome;ribonucleoprotein complex assembly Folate biosynthesis 81 81 81 44 44 44 244.5 0 3530600000 1925100000 1605500000 4809 IPI:IPI00420014.2;IPI:IPI00168235.4 U5 small nuclear ribonucleoprotein 200 kDa helicase;U5 snRNP-specific 200 kDa protein;Activating signal cointegrator 1 complex subunit 3-like 1;BRR2 homolog SNRNP200;ASCC3L1;HELIC2;KIAA0788 O75643-1;O75643 ENST00000323853;ENST00000349783 K01529 2 0.87254 1.7171 0.84321 1.1186 1.1873 1.1191 2-oxoacid_dh;Biotin_lipoyl cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;mitochondrial matrix;mitochondrial part;nucleus;organelle;organelle part;protein complex acyltransferase activity;binding;catalytic activity;dihydrolipoyllysine-residue succinyltransferase activity;protein binding;S-acyltransferase activity;transferase activity;transferase activity, transferring acyl groups acetyl-CoA catabolic process;acetyl-CoA metabolic process;catabolic process;cellular catabolic process;cellular metabolic process;cellular process;coenzyme catabolic process;coenzyme metabolic process;metabolic process;tricarboxylic acid cycle 3 3 3 6.4 6.4 6.4 48.729 3.0155E-12 86911000 47974000 38937000 4810 IPI:IPI00420108.5 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial;Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex;E2K DLST;DLTS P36957 ENST00000334220 1 1.1683 NaN NaN 1.5954 NaN NaN Ras cell part;intracellular;membrane;plasma membrane binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;protein binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cell communication;cellular process;intracellular signaling cascade;Ras protein signal transduction;sensory perception;sensory perception of sound;signal transduction;small GTPase mediated signal transduction;system process 4 1 1 27 6.9 6.9 21.656 1.6395E-60 297830 64551 233280 4811 IPI:IPI00423568.1;IPI:IPI00423570.3 GTPase KRas;K-Ras 2;Ki-Ras;c-K-ras;c-Ki-ras;GTPase KRas, N-terminally processed KRAS;KRAS2;RASK2 P01116-1;P01116;P01116-2 ENST00000256078;ENST00000311936;ENST00000395977 2 0.7614 1.3457 0.66632 0.93944 0.96117 0.83467 CUE;zf-C3HC4 cell fraction;insoluble fraction;integral to endoplasmic reticulum membrane;integral to membrane;integral to membrane of membrane fraction;intrinsic to endoplasmic reticulum membrane;intrinsic to membrane;intrinsic to organelle membrane;membrane fraction acid-amino acid ligase activity;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;protein binding;receptor activity;signal transducer activity;ubiquitin-protein ligase activity;zinc ion binding ER-nuclear signaling pathway;misfolded or incompletely synthesized protein catabolic process;protein complex assembly;protein modification process;protein polyubiquitination;proteolysis;response to stress;ubiquitin-dependent protein catabolic process 3 3 3 4.4 4.4 4.4 72.995 0.00072671 12556000 6492800 6063000 4812 IPI:IPI00423874.1 Autocrine motility factor receptor, isoform 2;gp78;RING finger protein 45 AMFR;RNF45 Q9UKV5 ENST00000290649 K10636 1 0.28387 NaN NaN 0.39357 NaN NaN centrosome;cytoplasmic part;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;microtubule;microtubule organizing center;non-membrane-bounded organelle;organelle;organelle part 2 2 2 2.1 2.1 2.1 141.75 0.00072415 1067400 844000 223390 4813 IPI:IPI00424603.5;IPI:IPI00853635.1 Centrosome and spindle pole-associated protein 1 CSPP1;CSPP Q1MSJ5-1;Q1MSJ5;Q1MSJ5-2 ENST00000262210;ENST00000389042 2 0.84649 1.2555 0.66164 1.1337 0.82037 0.88322 Hormone_recep;zf-C4 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle DNA binding;ligand-regulated transcription factor activity;nucleic acid binding;RNA polymerase II transcription factor activity;specific RNA polymerase II transcription factor activity;steroid hormone receptor activity;transcription factor activity biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription Adipocytokine signaling pathway;Non-small cell lung cancer;Pathways in cancer;PPAR signaling pathway;Small cell lung cancer;Thyroid cancer 4 4 2 7.7 7.7 4.1 56.921 3.7187E-07 2538700 1362200 1176500 4815 IPI:IPI00426305.2 Retinoic acid receptor RXR-beta;Retinoid X receptor beta;Nuclear receptor subfamily 2 group B member 2 RXRB;NR2B2 P28702 ENST00000374680;ENST00000374685;ENST00000383085;ENST00000383086;ENST00000383216;ENST00000383217 K08525 1 NaN 1.0505 1.2272 NaN 0.67236 1.777 tRNA_int_endo;tRNA_int_endo_N intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;protein complex;tRNA-intron endonuclease complex binding;catalytic activity;endonuclease activity;endoribonuclease activity;hydrolase activity;nuclease activity;nucleic acid binding;ribonuclease activity;tRNA-intron endonuclease activity;tRNA-specific ribonuclease activity mRNA processing;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA processing;RNA splicing, via endonucleolytic cleavage and ligation;tRNA metabolic process;tRNA splicing, via endonucleolytic cleavage and ligation 2 2 2 4.3 4.3 4.3 53.246 2.7667E-09 311690000 126410000 185280000 4816 IPI:IPI00427037.1;IPI:IPI00427039.1;IPI:IPI00427040.3 tRNA-splicing endonuclease subunit Sen2;tRNA-intron endonuclease Sen2 TSEN2;SEN2 Q8NCE0-1;Q8NCE0;Q8NCE0-2;Q8NCE0-3 ENST00000284995;ENST00000314571;ENST00000383797;ENST00000402228 K01170 3 0.55187 1.2524 NaN 0.69016 0.86305 NaN Fcf1 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 4 4 4 23.7 23.7 23.7 23.369 1.3038E-38 42399000 20823000 21575000 4817 IPI:IPI00427242.1 rRNA-processing protein FCF1 homolog FCF1;C14orf111;CGI-35 Q9Y324 ENST00000341162 K07158 1 0.70545 1.3715 0.80457 1.0507 0.89799 1.0956 SBDS;SBDS_C cell part;cytoplasm;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;spindle pole binding;cytoskeletal protein binding;microtubule binding;nucleic acid binding;protein binding;RNA binding;rRNA binding;tubulin binding cell motion;chemotaxis;immune system process;inner cell mass cell proliferation;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA processing;rRNA processing;system process 7 7 7 24.8 24.8 24.8 28.763 1.51E-10 68444000 35612000 32832000 4818 IPI:IPI00427330.3 Ribosome maturation protein SBDS;Shwachman-Bodian-Diamond syndrome protein SBDS;CGI-97 Q9Y3A5 ENST00000246868 1 0.85884 1.3307 0.77651 1.0739 0.96999 0.95782 L51_S25_CI-B8 intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;mitochondrial ribosome;non-membrane-bounded organelle;organellar ribosome;organelle;organelle part;ribonucleoprotein complex;ribosome binding;protein binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 7 7 7 30.7 30.7 30.7 23.431 5.6132E-46 208970000 110040000 98932000 4820 IPI:IPI00428285.3;IPI:IPI00428286.1;IPI:IPI00428287.1;IPI:IPI00428288.1 39S ribosomal protein L43, mitochondrial;Mitochondrial ribosomal protein bMRP36a MRPL43 Q8N983-1;Q8N983;Q8N983-2;Q8N983-3;Q8N983-4 ENST00000299179;ENST00000318325;ENST00000318364;ENST00000370234;ENST00000370242 4 0.56949 0.95897 0.58648 0.69991 0.65489 0.74126 LIM_bind cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;protein complex binding;LIM domain binding;protein binding;protein domain specific binding;transcription cofactor activity;transcription corepressor activity;transcription factor binding;transcription regulator activity;transcription repressor activity negative regulation of biosynthetic process;negative regulation of metabolic process;regulation of biosynthetic process;regulation of gene expression;regulation of immune system process;regulation of transcription, DNA-dependent 5 5 5 13.9 13.9 13.9 46.532 1.0086E-80 277770000 136250000 141530000 4821 IPI:IPI00856078.1;IPI:IPI00428954.1;IPI:IPI00760574.1;IPI:IPI00014634.1;IPI:IPI00855748.1;IPI:IPI00790687.1 LIM domain-binding protein 1;Nuclear LIM interactor;Carboxyl-terminal LIM domain-binding protein 2;LIM domain-binding factor CLIM2 LDB1;CLIM2 Q86U70-1;Q86U70;Q86U70-2;Q86U70-3 ENST00000361198 6 0.73627 1.4612 0.70006 0.98764 0.91986 0.93727 eRF1_1;eRF1_2;eRF1_3 cell part;cytoplasm;intracellular part binding;nucleic acid binding;protein binding;RNA binding;translation factor activity, nucleic acid binding;translation release factor activity;translation release factor activity, codon specific;translation termination factor activity cellular process;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of translation;regulation of translational termination;translational termination 23 23 23 50.3 50.3 50.3 49.03 0 1274600000 693470000 581100000 4822 IPI:IPI00429191.3 Eukaryotic peptide chain release factor subunit 1;TB3-1;Protein Cl1 ETF1;ERF1;RF1;SUP45L1 P62495 ENST00000360541 K03265 1 0.56387 1.1001 0.60782 0.74955 0.75503 0.81776 Pkinase cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;calcium ion binding;calmodulin binding;calmodulin-dependent protein kinase activity;catalytic activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding cell communication;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process;signal transduction Calcium signaling pathway;Long-term potentiation 11 11 11 26.6 26.6 26.6 51.925 6.5048E-127 149770000 80760000 69014000 4825 IPI:IPI00430411.1 Calcium/calmodulin-dependent protein kinase type IV;CAM kinase-GR CAMK4 Q16566 ENST00000282356 K05869 1 0.48609 0.91457 0.41394 0.63506 0.65274 0.59233 DEAD;Helicase_C;Sec63 cell part;cytoplasm;intracellular part ATP binding;ATP-dependent helicase activity;binding;catalytic activity;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription Folate biosynthesis 3 3 3 1.6 1.6 1.6 251.46 2.5329E-19 14510000 8410800 6099100 4826 IPI:IPI00430472.2 Activating signal cointegrator 1 complex subunit 3;ASC-1 complex subunit p200;Trip4 complex subunit p200;Helicase, ATP binding 1 ASCC3;HELIC1 Q8N3C0 ENST00000324696 K01529 1 0.74357 1.5965 NaN 1.0851 1.0135 NaN MIT cell death;cellular process;death 3 3 3 7.4 7.4 7.4 72.832 7.8724E-148 1879400 1026300 853130 4827 IPI:IPI00430622.1 Spartin;Trans-activated by hepatitis C virus core protein 1 SPG20;KIAA0610;TAHCCP1 Q8N0X7 ENST00000355182 1 NaN 1.6357 NaN NaN 0.93274 NaN S1;Tex_N cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;DNA binding;hydrolase activity;hydrolase activity, acting on ester bonds;nucleic acid binding;protein binding;RNA binding;transcription elongation regulator activity;transcription factor activity;transcription regulator activity chromatin organization;chromatin remodeling;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 13 1 1 26.6 4.8 4.8 61.3 5.1481E-31 2072400 1098500 973920 4828 IPI:IPI00430770.1 Transcription elongation factor SPT6;Tat-cotransactivator 2 protein SUPT6H;KIAA0162;SPT6H Q7KZ85-2;Q7KZ85 ENST00000314616;ENST00000347486 K11292 1 0.79942 1.1965 0.71977 1.0409 0.81419 0.89992 zf-CCHC cell part;cytoplasmic part;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transcription factor activity;transcription regulator activity;transition metal ion binding;zinc ion binding alcohol metabolic process;cholesterol biosynthetic process;lipid metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;steroid biosynthetic process;transcription 4 4 1 30.5 30.5 8.5 19.463 6.5254E-109 484990000 252200000 232790000 4830 IPI:IPI00430812.6;IPI:IPI00430813.3 Cellular nucleic acid-binding protein;Zinc finger protein 9 CNBP;RNF163;ZNF9 P62633-1;P62633;P62633-2 ENST00000307433;ENST00000393290 2 0.40272 NaN NaN 0.54066 NaN NaN zf-CCHC cell part;cytoplasmic part;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transcription factor activity;transcription regulator activity;transition metal ion binding;zinc ion binding alcohol metabolic process;cholesterol biosynthetic process;lipid metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;steroid biosynthetic process;transcription 4 1 1 30.5 7.2 7.2 18.412 2.2129E-43 268210 172730 95484 4831 IPI:IPI00430814.1 Cellular nucleic acid-binding protein;Zinc finger protein 9 CNBP;RNF163;ZNF9 P62633-3;P62633 ENST00000307433;ENST00000393290 1 0.7257 1.2394 0.66158 1.0258 0.77521 0.88551 Abi_HHR;SH3_1 cell fraction;cell junction;cell projection;cytoskeleton;cytosol;endoplasmic reticulum;filopodium;growth cone;insoluble fraction;lamellipodium;membrane fraction;neuron projection;nucleus;organelle;site of polarized growth;soluble fraction;synaptosome binding;cytoskeletal protein binding;protein binding cell communication;cell surface receptor linked signal transduction;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;signal transduction 9 9 5 17.9 17.9 12.4 55.08 4.3875E-170 172330000 80593000 91734000 4832 IPI:IPI00431025.1;IPI:IPI00827857.1;IPI:IPI00431031.5;IPI:IPI00431030.5;IPI:IPI00431027.3;IPI:IPI00431029.5;IPI:IPI00431026.3;IPI:IPI00431032.6;IPI:IPI00431033.3;IPI:IPI00935670.1 Abl interactor 1;Abelson interactor 1;Spectrin SH3 domain-binding protein 1;Eps8 SH3 domain-binding protein;e3B1;Nap1-binding protein;Abl-binding protein 4 ABI1;SSH3BP1 Q8IZP0-1;Q8IZP0;Q8IZP0-9;Q8IZP0-6;Q8IZP0-5;Q8IZP0-3;Q8IZP0-4;Q8IZP0-2;Q8IZP0-7;Q8IZP0-8;Q8IZP0-10 ENST00000355394;ENST00000376135;ENST00000376137;ENST00000376138;ENST00000376139;ENST00000376140;ENST00000376142 10 0.77673 1.5203 0.72786 1.0375 1.0488 0.98387 NAD_kinase catalytic activity;kinase activity;NAD+ kinase activity;phosphotransferase activity, alcohol group as acceptor;transferase activity;transferase activity, transferring phosphorus-containing groups metabolic process 9 9 9 21.9 21.9 21.9 49.432 3.4544E-104 103090000 67120000 35967000 4835 IPI:IPI00845432.1;IPI:IPI00431405.2;IPI:IPI00654793.2 UPF0465 protein C5orf33 C5orf33 Q4G0N4-1;Q4G0N4;Q4G0N4-2;Q4G0N4-3 ENST00000282512;ENST00000381937;ENST00000397338 3 1.2392 2.1878 1.0944 1.7423 1.375 1.4991 PRKCSH endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;membrane-enclosed lumen;organelle;organelle lumen;organelle part binding;protein binding 5 5 5 12 12 12 54.858 5.2434E-08 14003000 7466100 6537400 4837 IPI:IPI00748151.2;IPI:IPI00432337.3 XTP3-transactivated gene B protein;ER lectin C2orf30;XTP3TPB;UNQ1878/PRO4321 Q96DZ1-1;Q96DZ1;Q96DZ1-2 ENST00000185150;ENST00000378239 2 1.0168 2.413 NaN 1.3852 1.4447 NaN efhand;GAS2;Plectin;Spectrin cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle binding;calcium ion binding;cation binding;ion binding;metal ion binding;protein binding cell cycle arrest;cell cycle process;cellular process 42 4 4 8.8 1 1 670.14 0 1735200 950290 784930 4838 IPI:IPI00432363.1 Microtubule-actin cross-linking factor 1, isoform 4 MACF1;ABP620;ACF7;KIAA0465;KIAA1251 Q96PK2 ENST00000289893;ENST00000360115 1 0.44737 0.75411 0.41813 0.56897 0.53793 0.51434 AAA_4 adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cell differentiation;cellular developmental process;cellular process;developmental process 5 4 4 7.9 6.5 6.5 101.05 1.7615E-116 32499000 19383000 13115000 4839 IPI:IPI00433279.3;IPI:IPI00844250.1 Schlafen family member 5 SLFN5 Q08AF3-1;Q08AF3 ENST00000299977 2 NaN NaN 0.6047 NaN NaN 0.78306 KH_1 cell part;cytoplasm;intracellular part binding;nucleic acid binding;RNA binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 4 1 1 8.9 2.5 2.5 45.867 1.3872E-05 2375800 1334500 1041300 4840 IPI:IPI00434389.2 Activating signal cointegrator 1 complex subunit 1;ASC-1 complex subunit p50;Trip4 complex subunit p50 ASCC1;CGI-18 Q8N9N2-1;Q8N9N2 ENST00000342444;ENST00000394915;ENST00000394919 1 0.64937 3.6564 0.56899 0.87464 2.3656 0.76071 KH_1 cell part;cytoplasm;intracellular part binding;nucleic acid binding;RNA binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 4 4 1 9.8 9.8 2.9 43.581 2.5064E-14 29839000 15570000 14269000 4841 IPI:IPI00434390.2 Activating signal cointegrator 1 complex subunit 1;ASC-1 complex subunit p50;Trip4 complex subunit p50 ASCC1;CGI-18 Q8N9N2-2;Q8N9N2 ENST00000342444;ENST00000394915;ENST00000394919 1 0.75188 1.4572 0.78682 0.97871 0.96595 1.027 MBD binding;DNA binding;methyl-CpG binding;nucleic acid binding;nucleotide binding;protein binding;protein domain specific binding;satellite DNA binding;sequence-specific DNA binding;transcription regulator activity;transcription repressor activity biosynthetic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription 6 6 5 17.3 17.3 15.8 43.254 1.2445E-53 74062000 37875000 36187000 4842 IPI:IPI00434623.1;IPI:IPI00434624.1;IPI:IPI00434625.3 Methyl-CpG-binding domain protein 2;Methyl-CpG-binding protein MBD2;Demethylase MBD2 Q9UBB5-1;Q9UBB5;Q9UBB5-2 ENST00000256429;ENST00000398398 K11590 3 0.95808 1.9421 1.0281 1.2857 1.2267 1.3648 PX binding;lipid binding;phosphoinositide binding;phospholipid binding;protein binding cell communication;cellular process;establishment of localization;establishment of protein localization;protein transport;transport 7 6 6 34.3 30.2 30.2 19.73 2.8839E-18 121670000 62910000 58764000 4844 IPI:IPI00438170.3;IPI:IPI00844112.1 Sorting nexin-12 SNX12 Q9UMY4-1;Q9UMY4;Q9UMY4-2 ENST00000374274;ENST00000374281 2 0.74256 1.2811 0.72372 0.95622 0.88467 0.9072 PHD;zf-B_box;zf-C3HC4 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;protein binding;transcription cofactor activity;transcription corepressor activity;transcription factor activity;transcription factor binding;transcription repressor activity;zinc ion binding cell morphogenesis;cell morphogenesis involved in differentiation;epithelial to mesenchymal transition;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 28 28 28 42.3 42.3 42.3 88.549 0 3553800000 1873000000 1680800000 4846 IPI:IPI00438229.2;IPI:IPI00438230.3 Transcription intermediary factor 1-beta;Tripartite motif-containing protein 28;Nuclear corepressor KAP-1;KRAB-associated protein 1;KRAB-interacting protein 1;RING finger protein 96 TRIM28;KAP1;RNF96;TIF1B Q13263-1;Q13263;Q13263-2 ENST00000253024;ENST00000341753 K08882 2 0.60335 1.8458 NaN 0.81529 1.189 NaN MBD;zf-CXXC cell part;intracellular organelle part;intracellular part;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part binding;DNA binding;methyl-CpG binding;nucleic acid binding;nucleotide binding;protein binding;transcription cofactor activity;transcription corepressor activity;transcription factor activity;transcription factor binding;zinc ion binding metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent 3 3 3 5.1 5.1 5.1 66.606 7.2559E-46 5791100 3506000 2285100 4848 IPI:IPI00438701.1;IPI:IPI00438702.1;IPI:IPI00438705.1;IPI:IPI00438706.1;IPI:IPI00438703.1;IPI:IPI00438707.3;IPI:IPI00854577.1;IPI:IPI00941642.1 Methyl-CpG-binding domain protein 1;Methyl-CpG-binding protein MBD1;Protein containing methyl-CpG-binding domain 1;CXXC-type zinc finger protein 3 MBD1;CXXC3;PCM1 Q9UIS9-1;Q9UIS9;Q9UIS9-2;Q9UIS9-5;Q9UIS9-6;Q9UIS9-3;Q9UIS9-7;Q9UIS9-8;Q9UIS9-4 ENST00000269468;ENST00000269471;ENST00000339998;ENST00000347968;ENST00000349085;ENST00000353909;ENST00000398495 K11589 8 0.84629 1.9934 1.0162 1.1706 1.2329 1.2281 ADH_N;ADH_zinc_N cell part;cytoplasmic part;cytosol;intracellular part binding;catalytic activity;NADPH:quinone reductase activity;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;zinc ion binding cellular metabolic process;cellular process;cofactor metabolic process;metabolic process;oxidation reduction;quinone cofactor metabolic process 4 4 4 15.5 15.5 15.5 38.696 4.7215E-13 13809000 6799500 7009400 4849 IPI:IPI00438923.3 Quinone oxidoreductase-like protein 1;QOH-1;Zeta-crystallin homolog;4P11 CRYZL1 O95825 ENST00000381554 K00540 1 0.79674 1.4648 NaN 1.0755 0.98346 NaN MBD binding;DNA binding;nucleic acid binding;protein binding biosynthetic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription 5 4 4 24.1 22 22 32.844 5.6117E-73 15478000 8023900 7453800 4851 IPI:IPI00439194.1;IPI:IPI00439195.1 Methyl-CpG-binding domain protein 3;Methyl-CpG-binding protein MBD3 MBD3 O95983-1;O95983;O95983-2 ENST00000156825;ENST00000355664 K11591 2 0.62547 1.2628 NaN 0.77428 0.89763 NaN Ank;SH3_1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding;transcription cofactor activity;transcription corepressor activity;transcription factor binding;transcription regulator activity;transcription repressor activity apoptosis;biosynthetic process;cell death;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 2 2 2 2.4 2.4 2.4 89.09 0.0019238 2524000 1402400 1121600 4852 IPI:IPI00439948.6;IPI:IPI00181006.4 RelA-associated inhibitor;Inhibitor of ASPP protein;PPP1R13B-like protein;NFkB-interacting protein 1 PPP1R13L;IASPP;NKIP1;PPP1R13BL;RAI Q8WUF5-1;Q8WUF5;Q8WUF5-2 ENST00000360957 2 0.79711 1.5752 0.81114 1.0319 1.0659 1.0303 ATP-synt_ab;ATP-synt_ab_C;ATP-synt_ab_N macromolecular complex;membrane;mitochondrial matrix;mitochondrial proton-transporting ATP synthase complex;plasma membrane;protein complex;proton-transporting two-sector ATPase complex;proton-transporting two-sector ATPase complex, catalytic domain ATP binding;binding;catalytic activity;cation transmembrane transporter activity;ion transmembrane transporter activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;receptor binding;transporter activity negative regulation of endothelial cell proliferation;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;regulation of endothelial cell proliferation Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 36 36 35 63.3 63.3 62.2 59.75 0 16083000000 8439000000 7643800000 4853 IPI:IPI00440493.2;IPI:REV_IPI00157365.2;IPI:REV_IPI00377271.1 ATP synthase subunit alpha, mitochondrial ATP5A1;ATP5A;ATP5AL2;ATPM P25705 ENST00000282050;ENST00000398752 K02132 3 0.8664 1.6497 0.86935 1.2136 1.0467 1.2102 RRM_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding 10 10 10 38.2 38.2 38.2 46.089 2.0169E-156 575010000 297080000 277930000 4854 IPI:IPI00940039.1;IPI:IPI00440689.1 Polymerase delta-interacting protein 3;46 kDa DNA polymerase delta interaction protein;p46 POLDIP3;KIAA1649;PDIP46 Q9BY77-1;Q9BY77;Q9BY77-2 ENST00000252115;ENST00000348657 2 0.88944 1.6473 0.98147 1.1967 1.0917 1.3791 Bromodomain cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding 13 13 10 10.6 10.6 9 152.22 1.1708E-31 195420000 100710000 94703000 4855 IPI:IPI00440727.1;IPI:IPI00440728.1;IPI:IPI00014266.1;IPI:IPI00410716.1 Bromodomain-containing protein 4;HUNK1 protein BRD4;HUNK1 O60885-1;O60885;O60885-2 ENST00000263377;ENST00000392878 K11722 4 0.6593 1.5304 0.76935 0.87539 1.002 1.0426 FAA_hydrolase binding;calcium ion binding;catalytic activity;cation binding;hydrolase activity;ion binding;magnesium ion binding;metal ion binding;protein binding metabolic process 5 5 5 35.8 35.8 35.8 24.91 2.1099E-42 27479000 15922000 11557000 4856 IPI:IPI00440828.1;IPI:IPI00552360.2 Fumarylacetoacetate hydrolase domain-containing protein 1;YISK-like FAHD1;C16orf36;YISKL Q6P587-2;Q6P587;Q6P587-1 ENST00000326061;ENST00000382666;ENST00000382668 2 0.68797 1.6928 0.77064 0.91742 1.0943 1.0386 Glyco_hydro_35 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;lysosome;lytic vacuole;membrane-bounded organelle;organelle;perinuclear region of cytoplasm;vacuole beta-galactosidase activity;binding;catalytic activity;cation binding;galactosidase activity;hydrolase activity;hydrolase activity, acting on glycosyl bonds;hydrolase activity, hydrolyzing O-glycosyl compounds;ion binding;protein binding carbohydrate metabolic process;metabolic process;primary metabolic process Galactose metabolism;Glycosaminoglycan degradation;Glycosphingolipid biosynthesis - ganglio series;Other glycan degradation;Sphingolipid metabolism 8 8 8 14.2 14.2 14.2 76.074 3.6655E-46 39868000 22090000 17779000 4857 IPI:IPI00441344.2;IPI:IPI00441550.4;IPI:IPI00185998.6;IPI:IPI00414585.6 Beta-galactosidase;Acid beta-galactosidase;Elastin receptor 1 GLB1;ELNR1 P16278-1;P16278;P16278-2 ENST00000307363;ENST00000307377 K12309 4 0.74238 1.4239 0.67193 0.94359 0.95096 0.88957 PRMT5 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;histone-arginine N-methyltransferase activity;methyltransferase activity;N-methyltransferase activity;protein binding;protein methyltransferase activity;S-adenosylmethionine-dependent methyltransferase activity chromatin organization;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein amino acid methylation;protein modification process;regulation of transcription, DNA-dependent;spliceosomal snRNP biogenesis;transcription Cell cycle - yeast 18 18 18 32.8 32.8 32.8 72.683 2.2942E-137 1304800000 710570000 594220000 4858 IPI:IPI00441473.3 Protein arginine N-methyltransferase 5;Histone-arginine N-methyltransferase PRMT5;Shk1 kinase-binding protein 1 homolog;SKB1Hs;Jak-binding protein 1;72 kDa ICln-binding protein PRMT5;HRMT1L5;IBP72;JBP1;SKB1 O14744 ENST00000324366 K02516 1 0.67778 1.6076 NaN 0.91684 1.0521 NaN Pex19 brush border membrane;cell projection membrane;intracellular membrane-bounded organelle;intracellular organelle;membrane;membrane-bounded organelle;microbody;microbody membrane;organelle;organelle membrane;organelle part;peroxisomal membrane binding;protein binding establishment of localization;establishment of protein localization;intracellular protein transport;intracellular transport;peroxisomal transport;protein targeting;protein targeting to peroxisome;protein transport;transport 5 2 2 23.1 12.4 12.4 32.806 1.7203E-101 10696000 6020200 4675900 4859 IPI:IPI00441867.1;IPI:IPI00939321.1 Peroxisomal biogenesis factor 19;Peroxin-19;Peroxisomal farnesylated protein;33 kDa housekeeping protein PEX19;HK33;PXF;OK/SW-cl.22 P40855-1;P40855;P40855-5 ENST00000368071;ENST00000368072 2 0.68264 1.2618 NaN 0.86623 0.89353 NaN PH;RhoGAP;SH3_1 cell part;intracellular binding;enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity;protein binding biological regulation;cell communication;cellular process;regulation of biological process;regulation of cellular process;signal transduction 4 2 2 3.8 2.5 2.5 81.149 0.00051359 8698900 5483400 3215500 4860 IPI:IPI00442053.3;IPI:IPI00747804.1;IPI:IPI00414939.1 Rho GTPase-activating protein 9;Rho-type GTPase-activating protein 9 ARHGAP9 Q9BRR9-2;Q9BRR9;Q9BRR9-1;Q9BRR9-3 ENST00000356411;ENST00000393797 3 0.70788 1.4669 0.85923 0.94853 0.96386 1.13 LIM cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding 5 5 5 38.9 38.9 38.9 20.567 4.1013E-17 66993000 34890000 32103000 4861 IPI:IPI00442073.5 Cysteine and glycine-rich protein 1 CSRP1;CSRP;CYRP P21291 ENST00000340006;ENST00000367306 K09377 1 0.71774 1.2419 NaN 1.0788 0.8357 NaN cell part;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;cation binding;double-stranded RNA binding;ion binding;metal ion binding;nucleic acid binding;RNA binding;transition metal ion binding;zinc ion binding apoptosis;cell death;cellular process;death;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;programmed cell death;RNA metabolic process;RNA processing 4 4 4 17.6 17.6 17.6 35.771 2.2341E-35 11785000 5936900 5847800 4862 IPI:IPI00442165.1;IPI:IPI00550375.3 Zinc finger protein 346;Just another zinc finger protein ZNF346;JAZ Q9UL40-2;Q9UL40;Q9UL40-1 ENST00000261948;ENST00000358149 2 0.82671 1.3113 0.78348 1.0772 0.81823 1.0303 Peptidase_S9;Peptidase_S9_N cell part;cytoplasmic part;cytosol;intracellular part catalytic activity;endopeptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides;serine hydrolase activity;serine-type endopeptidase activity;serine-type peptidase activity biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis 6 6 6 11.7 11.7 11.7 83.926 8.9033E-22 37663000 19750000 17913000 4863 IPI:IPI00442171.4;IPI:IPI00619908.2;IPI:IPI00880064.1;IPI:IPI00760871.1 Prolyl endopeptidase-like;Prolylendopeptidase-like PREPL;KIAA0436 Q4J6C6-1;Q4J6C6;Q4J6C6-3;Q4J6C6-4;Q4J6C6-2 ENST00000260648;ENST00000378511;ENST00000378520;ENST00000409272;ENST00000409936;ENST00000410081 4 NaN NaN 0.78709 NaN NaN 0.94181 Abi_HHR;SH3_1 cell part;cell projection;cytoplasmic part;cytoskeleton;cytosol;filopodium;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;lamellipodium;non-membrane-bounded organelle;organelle binding;cytoskeletal adaptor activity;cytoskeletal protein binding;DNA binding;enzyme binding;kinase binding;nucleic acid binding;protein binding;protein domain specific binding;SH3 domain binding;SH3/SH2 adaptor activity;signal transducer activity actin filament organization;cell motion;cytoskeleton organization;metabolic process;organelle organization;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process Regulation of actin cytoskeleton 5 1 1 7.2 1.8 1.8 55.663 5.9427E-10 10541000 5775600 4765900 4864 IPI:IPI00442210.1;IPI:IPI00442211.1;IPI:IPI00442214.1 Abl interactor 2;Abelson interactor 2;Abl-binding protein 3;Arg-binding protein 1 ABI2;ARGBPIA Q9NYB9-1;Q9NYB9;Q9NYB9-2 ENST00000261016;ENST00000261017;ENST00000295851 K05751 3 0.70991 1.5147 NaN 0.99419 0.91951 NaN zf-NF-X1 cell part;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transcription factor activity;transcription regulator activity;transition metal ion binding;zinc ion binding regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent 6 6 6 10.6 10.6 10.6 101.34 7.3746E-55 17061000 8349100 8711700 4865 IPI:IPI00442274.3;IPI:IPI00745540.2 NF-X1-type zinc finger protein NFXL1;Ovarian zinc finger protein NFXL1;OZFP Q6ZNB6-1;Q6ZNB6;Q6ZNB6-2 ENST00000329043;ENST00000381538 2 0.78954 1.7955 0.93961 1.0038 1.1718 1.2 endoplasmic reticulum;integral to membrane;integral to plasma membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;intrinsic to plasma membrane;membrane-bounded organelle;organelle binding;protein binding 8 8 6 59.9 59.9 46.2 20.652 5.9887E-57 205890000 104270000 101620000 4866 IPI:IPI00443909.1 Protein canopy homolog 2;MIR-interacting saposin-like protein;Transmembrane protein 4;Putative secreted protein ZSIG9 CNPY2;MSAP;TMEM4;ZSIG9;UNQ1943/PRO4426 Q9Y2B0-1;Q9Y2B0 ENST00000273308 1 NaN 1.5781 NaN NaN 1.0098 NaN Ric8 cell cortex;cell part;cytoplasmic part;cytosol;intracellular part;membrane;plasma membrane binding;enzyme regulator activity;G-protein alpha-subunit binding;GTPase regulator activity;guanyl-nucleotide exchange factor activity;nucleoside-triphosphatase regulator activity;protein binding biological regulation;regulation of biological process;regulation of cell communication;regulation of cellular process;regulation of G-protein coupled receptor protein signaling pathway;regulation of signal transduction 4 3 3 11.2 8.6 8.6 60.839 6.3742E-108 57851000 56661000 1189800 4867 IPI:IPI00018771.3;IPI:IPI00746555.1;IPI:IPI00746112.1;IPI:IPI00443951.1 Synembryn-B;Brain synembrin;Protein Ric-8B RIC8B Q9NVN3-1;Q9NVN3;Q9NVN3-2;Q9NVN3-3;Q9NVN3-4 ENST00000261399;ENST00000392836;ENST00000392837 4 NaN 3.2475 NaN NaN 1.9894 NaN Ank;IQ;Myosin_head cell part;cytoplasmic part;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;membrane;myosin complex;nuclear part;nucleoplasm;organelle part;perinuclear region of cytoplasm;plasma membrane;protein complex actin binding;ATP binding;binding;catalytic activity;cytoskeletal protein binding;hydrolase activity;motor activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity cerebellum development;developmental process;negative regulation of cell cycle process;negative regulation of cell proliferation;regulation of cell cycle process;regulation of mitotic cell cycle;regulation of S phase of mitotic cell cycle 2 2 2 1.5 1.5 1.5 206.13 0.0052894 6912000 3788400 3123600 4868 IPI:IPI00444012.2;IPI:IPI00847384.1;IPI:IPI00643872.1;IPI:IPI00328367.6 Myosin-XVI;Unconventional myosin-16 MYO16;KIAA0865;MYO16B Q9Y6X6-1;Q9Y6X6;Q9Y6X6-2;Q9Y6X6-4;Q9Y6X6-3 ENST00000356711;ENST00000357550 4 0.71612 1.3313 0.65885 0.9242 0.88656 0.86641 PHD;PWWP;SET cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;lysine N-methyltransferase activity;methyltransferase activity;N-methyltransferase activity;protein binding;protein methyltransferase activity;S-adenosylmethionine-dependent methyltransferase activity;zinc ion binding chromatin organization;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;one-carbon metabolic process;protein amino acid methylation;protein modification process;regulation of transcription, DNA-dependent;transcription Lysine degradation 4 4 4 4.6 4.6 4.6 161.61 0.00031805 13842000 7280700 6561500 4869 IPI:IPI00743157.2;IPI:IPI00792713.1;IPI:IPI00444331.3;IPI:IPI00307783.9 Histone-lysine N-methyltransferase NSD3;Nuclear SET domain-containing protein 3;Wolf-Hirschhorn syndrome candidate 1-like protein 1;WHSC1-like 1 isoform 9 with methyltransferase activity to lysine WHSC1L1;NSD3;DC28 Q9BZ95-1;Q9BZ95;Q9BZ95-2;Q9BZ95-4;Q9BZ95-3 ENST00000316985;ENST00000317025 K11425 4 0.55715 1.1423 0.37135 0.75887 0.81494 0.49935 WD40 cytoplasmic part;cytosol;endosomal part;endosome membrane;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;organelle;organelle membrane;organelle part 3 3 2 4.4 4.4 3.1 101.37 6.642E-09 15186000 8187000 6998600 4870 IPI:IPI00444371.3;IPI:IPI00872729.1 WD repeat-containing protein 44;Rabphilin-11 WDR44 Q5JSH3-1;Q5JSH3;Q5JSH3-2 ENST00000254029 2 0.56711 0.99359 0.66092 0.75011 0.65138 0.82728 cell part;cytoplasmic mRNA processing body;cytoplasmic part;intracellular part;macromolecular complex;ribonucleoprotein complex ATP binding;binding;catalytic activity;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity;RNA binding biosynthetic process;metabolic process;mRNA cleavage;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;RNA processing;transcription 19 19 19 25.2 25.2 25.2 113.67 1.5687E-210 372740000 154550000 218190000 4871 IPI:IPI00444452.3;IPI:IPI00444454.3;IPI:IPI00005638.2;IPI:IPI00215671.3;IPI:IPI00929442.1 Putative helicase MOV-10;Moloney leukemia virus 10 protein MOV10;KIAA1631 Q9HCE1-1;Q9HCE1;Q9HCE1-2 ENST00000357443;ENST00000369645;ENST00000369648 5 0.7854 1.3815 0.76684 1.0234 0.92317 0.98432 DUF908;DUF913;HECT;UBA;WWE cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle acid-amino acid ligase activity;binding;catalytic activity;DNA binding;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleic acid binding;protein binding;small conjugating protein ligase activity;ubiquitin-protein ligase activity catabolic process;cellular component organization;cellular process;chromatin organization;macromolecule catabolic process;metabolic process;organelle organization;protein modification process;protein polyubiquitination;protein ubiquitination;proteolysis Ubiquitin mediated proteolysis 63 63 63 17.7 17.7 17.7 481.89 0 1304600000 704060000 600540000 4872 IPI:IPI00456919.2;IPI:IPI00643153.1;IPI:IPI00445401.3 E3 ubiquitin-protein ligase HUWE1;HECT, UBA and WWE domain-containing protein 1;Upstream regulatory element-binding protein 1;Mcl-1 ubiquitin ligase E3;ARF-binding protein 1;Large structure of UREB1;Homologous to E6AP carboxyl terminus homologous protein 9 HUWE1;KIAA0312;KIAA1578;UREB1;HSPC272 Q7Z6Z7-1;Q7Z6Z7;Q7Z6Z7-3;Q7Z6Z7-2 ENST00000262854;ENST00000276009;ENST00000342160 K10592 3 0.73101 1.2984 0.82868 0.94013 0.86094 1.0895 binding 2 2 2 1.8 1.8 1.8 111.15 0.0054725 9946800 4870700 5076100 4873 IPI:IPI00445972.3;IPI:IPI00888252.2 Protein FAM179A FAM179A Q6ZUX3-1;Q6ZUX3;Q6ZUX3-2 ENST00000344886;ENST00000379558;ENST00000403861 2 NaN 1.983 NaN NaN 1.207 NaN ATG16;WD40 autophagic vacuole;cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;organelle;pre-autophagosomal structure membrane;vacuole binding;protein binding anatomical structure formation;autophagic vacuole formation;cellular component assembly;cellular component organization;cellular process;organelle organization;protein complex assembly;protein transport;transport;vesicle organization 2 2 2 3.6 3.6 3.6 68.264 2.0666E-12 3011700 2295700 715970 4874 IPI:IPI00470446.2;IPI:IPI00555905.1;IPI:IPI00446614.1;IPI:IPI00432751.1 Autophagy-related protein 16-1;APG16-like 1 ATG16L1;APG16L;UNQ9393/PRO34307 Q676U5-1;Q676U5;Q676U5-2;Q676U5-4;Q676U5-3 ENST00000373525;ENST00000392018;ENST00000392020;ENST00000392021 4 0.53693 1.2019 0.54695 0.74422 0.78167 0.75074 HEAT cell part;integrator complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;protein binding cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;snRNA metabolic process;snRNA processing 8 8 8 10.3 10.3 10.3 108.17 4.7683E-28 1065700000 582380000 483350000 4875 IPI:IPI00446765.2;IPI:IPI00795935.1;IPI:IPI00748403.4;IPI:IPI00884212.1;IPI:IPI00102193.5;IPI:IPI00419468.5 Integrator complex subunit 4 INTS4;MSTP093 Q96HW7-1;Q96HW7;Q96HW7-2 ENST00000354849 6 0.99628 1.9106 1.0346 1.3056 1.2991 1.3863 SH3_2 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding immune system process;NLS-bearing substrate import into nucleus;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein import into nucleus;protein modification process;protein targeting;transport 10 10 9 13.9 13.9 13.9 85.386 3.7952E-25 179490000 95401000 84090000 4876 IPI:IPI00446986.3 FYN-binding protein;FYN-T-binding protein;FYB-120/130;p120/p130;SLP-76-associated phosphoprotein;SLAP-130;Adhesion and degranulation promoting adaptor protein FYB;SLAP130 O15117 ENST00000263405;ENST00000351578 1 0.69579 1.5469 0.7579 0.89071 1.0064 0.95922 adh_short cell part;membrane catalytic activity;L-xylulose reductase (NADP+) activity;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor alcohol metabolic process;carbohydrate metabolic process;D-xylose metabolic process;glucose metabolic process;hexose metabolic process;metabolic process;monosaccharide metabolic process;pentose metabolic process;primary metabolic process Pentose and glucuronate interconversions 10 10 10 43.4 43.4 43.4 25.913 7.5348E-127 159190000 86016000 73179000 4877 IPI:IPI00448095.3 L-xylulose reductase;Dicarbonyl/L-xylulose reductase;Kidney dicarbonyl reductase;Carbonyl reductase II;Sperm surface protein P34H DCXR Q7Z4W1 ENST00000306869 K03331 1 0.72702 0.99035 0.50605 0.9164 0.67913 0.67825 SAM_2 cell part;intrinsic to membrane;membrane part molecular transducer activity;receptor activity;signal transducer activity;transmembrane receptor activity cell communication;cellular process;defense response;immune response;immune system process;innate immune response;regulation of biological process;regulation of cellular process;response to stimulus;response to stress;signal transduction 6 6 6 9.9 9.9 9.9 79.387 2.2701E-31 2620100 1488200 1132000 4879 IPI:IPI00448630.1;IPI:IPI00007919.1 Sterile alpha and TIR motif-containing protein 1;Sterile alpha and Armadillo repeat protein;Tir-1 homolog SARM1;KIAA0524;SARM Q6SZW1-1;Q6SZW1;Q6SZW1-2 ENST00000003834;ENST00000379061 2 0.63709 1.7566 0.90661 0.86721 1.1571 1.1611 axon;cell part;cell projection;neuron projection developmental process;multicellular organismal development;multicellular organismal process 4 4 4 9.1 9.1 9.1 73.608 3.7329E-17 25648000 14737000 10912000 4880 IPI:IPI00448751.4;IPI:IPI00854700.3;IPI:IPI00921922.1;IPI:IPI00922178.1;IPI:IPI00854856.3;IPI:IPI00854567.3;IPI:IPI00921857.1 Shootin-1 KIAA1598 A0MZ66-3;A0MZ66;A0MZ66-1;A0MZ66-6;A0MZ66-5;A0MZ66-4;A0MZ66-2;A0MZ66-7 ENST00000355371;ENST00000392903 7 0.92555 1.8311 0.90148 1.2356 1.1477 1.2189 BRCT;PADR1;PARP;PARP_reg;WGR;zf-PARP cell part;envelope;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear envelope;nuclear part;nucleolus;organelle;organelle envelope;organelle part binding;catalytic activity;DNA binding;NAD+ ADP-ribosyltransferase activity;nucleic acid binding;nucleotide binding;protein binding;transferase activity;transferase activity, transferring glycosyl groups;zinc ion binding DNA metabolic process;DNA repair;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein modification process;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent Base excision repair 47 47 47 50.5 50.5 50.5 113.08 0 4990700000 2539000000 2451600000 4881 IPI:IPI00449049.5 Poly [ADP-ribose] polymerase 1;ADPRT;NAD(+) ADP-ribosyltransferase 1;Poly[ADP-ribose] synthetase 1 PARP1;ADPRT;PPOL P09874 ENST00000366794 K10798 1 NaN 7.6656 NaN NaN 5.4349 NaN C1-set antigen binding;binding;protein binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular process;immune response;immune system process;macromolecule metabolic process;metabolic process;protein metabolic process;protein modification process;protein-chromophore linkage 7 7 3 18.5 18.5 7.3 53.224 5.2421E-62 32056000 31347000 708710 4882 IPI:IPI00449920.1 Ig alpha-1 chain C region IGHA1 P01876 ENST00000390547 1 0.84479 1.3788 NaN 1.105 0.91441 NaN cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding 4 4 4 2.9 2.9 2.9 203.35 9.7183E-80 2556100 1451100 1105000 4883 IPI:IPI00449923.1;IPI:IPI00449924.1;IPI:IPI00449925.4;IPI:IPI00449926.3 Retinoic acid-induced protein 1 RAI1;KIAA1820 Q7Z5J4-1;Q7Z5J4;Q7Z5J4-2;Q7Z5J4-3;Q7Z5J4-4 ENST00000261641;ENST00000315321;ENST00000353383;ENST00000355970;ENST00000395776 4 1.114 2.0512 1.0636 1.447 1.3395 1.3599 Sen15 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;protein binding cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;tRNA metabolic process;tRNA processing 2 2 2 24 24 24 18.641 3.1512E-121 23676000 13036000 10639000 4884 IPI:IPI00450071.5 tRNA-splicing endonuclease subunit Sen15;tRNA-intron endonuclease Sen15 TSEN15;C1orf19;SEN15 Q8WW01 ENST00000361641 1 0.7321 1.717 0.55371 0.97546 1.1557 0.73218 IPK cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;inositol or phosphatidylinositol kinase activity;inositol trisphosphate 3-kinase activity;kinase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;transferase activity cellular process;glycerophospholipid metabolic process;lipid metabolic process;lipid modification;metabolic process;organophosphate metabolic process;phosphate metabolic process;phospholipid metabolic process;phosphorus metabolic process;phosphorylation 4 4 4 9.3 9.3 9.3 50.235 0.0013705 4180700 2301900 1878800 4885 IPI:IPI00452669.2 Inositol hexakisphosphate kinase 1;Inositol hexaphosphate kinase 1 IP6K1;IHPK1;KIAA0263 Q92551 ENST00000321599 K07756 1 0.79179 1.4169 0.8516 1.0754 0.96834 1.1583 cwf18 5 5 5 22.3 22.3 22.3 19.181 1.2145E-20 165100000 85885000 79217000 4887 IPI:IPI00453463.4 Coiled-coil domain-containing protein 12 CCDC12 Q8WUD4 ENST00000292314 1 0.70505 1.4179 0.74014 0.91758 0.95552 0.96416 Histone cell part;chromosomal part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;nucleosome;organelle part;protein-DNA complex binding;DNA binding;nucleic acid binding;protein binding anatomical structure formation;cell communication;cellular component organization;cellular process;chromatin organization;intracellular signaling cascade;nucleosome assembly;organelle organization;second-messenger-mediated signaling;signal transduction Systemic lupus erythematosus 16 16 16 71.8 71.8 71.8 11.367 0 87010000000 45489000000 41521000000 4888 IPI:IPI00453473.6 Histone H4 HIST1H4A;H4/A;H4FA;HIST1H4B;H4/I;H4FI;HIST1H4C;H4/G;H4FG;HIST1H4D;H4/B;H4FB;HIST1H4E;H4/J;H4FJ;HIST1H4F;H4/C;H4FC;HIST1H4H;H4/H;H4FH;HIST1H4I;H4/M;H4FM;HIST1H4J;H4/E;H4FE;HIST1H4K;H4/D;H4FD;HIST1H4L;H4/K;H4FK;HIST2H4A;H4/N;H4F2;H4FN;HIST2H4;HIST2H4B;H4/O;H4FO;HIST4H4 P62805 ENST00000289352;ENST00000340756;ENST00000354348;ENST00000355057;ENST00000355981;ENST00000357549;ENST00000358064;ENST00000358910;ENST00000359907;ENST00000360441;ENST00000369157;ENST00000369165;ENST00000377364;ENST00000377727;ENST00000377745;ENST00000377803;ENST00000392932;ENST00000392933;ENST00000392938;ENST00000392939;ENST00000392941 K11254 1 0.70183 1.4183 0.65211 0.96634 0.94351 0.97001 PHD binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding 6 6 6 8.6 8.6 8.6 100.05 2.5004E-86 34638000 19052000 15586000 4889 IPI:IPI00454969.4;IPI:IPI00941211.1 PHD finger protein 14 PHF14;KIAA0783 O94880-1;O94880;O94880-2 ENST00000303905;ENST00000403050 2 0.76013 1.6309 0.75751 1.0666 0.98477 1.0329 RRM_1 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 22 22 2 47.8 47.8 3.9 37.029 0 6120400000 3206500000 2913900000 4890 IPI:IPI00455134.1 Heterogeneous nuclear ribonucleoprotein A3 HNRNPA3;HNRPA3 P51991-2;P51991 ENST00000392524 1 0.68124 1.6498 0.7601 0.96278 1.026 0.9883 Nfu_N;NifU cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;nucleus;organelle 4 iron, 4 sulfur cluster binding;binding;cation binding;ion binding;iron ion binding;iron-sulfur cluster binding;metal cluster binding;metal ion binding;transition metal ion binding biosynthetic process;cellular biosynthetic process;cellular metabolic process;cellular process;cofactor biosynthetic process;cofactor metabolic process;iron-sulfur cluster assembly;metabolic process;metallo-sulfur cluster assembly 2 2 2 15 15 15 28.462 2.4428E-13 7200600 3962100 3238500 4891 IPI:IPI00455153.2 NFU1 iron-sulfur cluster scaffold homolog, mitochondrial;HIRA-interacting protein 5 NFU1;HIRIP5;CGI-33 Q9UMS0 ENST00000404290 1 0.76839 1.3487 NaN 1.054 0.85096 NaN bleb;cell junction;cell part;cell projection;cell-cell junction;gap junction;integral to membrane;intrinsic to membrane;membrane part;plasma membrane part cation transport;ion transport;positive regulation of biological process;positive regulation of cellular process;regulation of cytokine production;regulation of localization;regulation of protein localization;transport 2 2 2 6.1 6.1 6.1 48.059 7.3378E-19 6241300 3441100 2800100 4892 IPI:IPI00455165.1;IPI:IPI00455166.1 Pannexin-1 PANX1;MRS1;UNQ2529/PRO6028 Q96RD7-1;Q96RD7;Q96RD7-2 ENST00000227638 2 0.52151 1.0047 0.61514 0.70539 0.70864 0.8283 Met_10 cell part;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part catalytic activity;methyltransferase activity;RNA methyltransferase activity;S-adenosylmethionine-dependent methyltransferase activity;tRNA (guanine) methyltransferase activity;tRNA (guanine-N1-)-methyltransferase activity;tRNA methyltransferase activity cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;tRNA metabolic process;tRNA processing 6 6 6 13.6 13.6 13.6 58.246 9.0331E-63 31176000 18112000 13064000 4893 IPI:IPI00455268.4 tRNA (guanine-N(1)-)-methyltransferase;M1G-methyltransferase;tRNA [GM37] methyltransferase;tRNA methyltransferase 5 TRMT5;KIAA1393 Q32P41 ENST00000261249 K07055 1 0.96449 1.7714 0.93316 1.2399 1.1791 1.222 Annexin basement membrane;cell fraction;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;extracellular space;intracellular organelle;melanosome;membrane-bounded organelle;membrane-bounded vesicle;organelle;soluble fraction;vesicle binding;calcium ion binding;calcium-dependent phospholipid binding;cytoskeletal protein binding;enzyme inhibitor activity;enzyme regulator activity;ion binding;lipid binding;phospholipase inhibitor activity;phospholipid binding;protein binding anatomical structure development;developmental process;skeletal system development;system development 33 33 33 75.4 75.4 75.4 40.411 0 4513700000 2275800000 2237800000 4894 IPI:IPI00418169.3;IPI:IPI00455315.4;IPI:IPI00334627.3 Annexin A2;Annexin-2;Annexin II;Lipocortin II;Calpactin I heavy chain;Chromobindin-8;p36;Protein I;Placental anticoagulant protein IV;Putative annexin A2-like protein;Annexin A2 pseudogene 2;Lipocortin II pseudogene ANXA2;ANX2;ANX2L4;CAL1H;LPC2D;ANXA2P2;ANX2L2;ANX2P2;LPC2B P07355-2;P07355;P07355-1;A6NMY6 ENST00000332680;ENST00000356292;ENST00000396024 3 1.0136 1.6335 NaN 1.4335 0.99829 NaN 2 2 2 37.2 37.2 37.2 8.8268 1.6085E-48 4115900 1977300 2138600 4896 IPI:IPI00455446.1;IPI:IPI00455444.1 Protein GRINL1A, isoforms 4/5 GRINL1A Q6EEV4-2;Q6EEV4;Q6EEV4-1 2 0.81861 1.7007 0.91733 1.0677 1.1194 1.2268 SH3_2 cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part binding;protein binding exocytosis;negative regulation of cell adhesion;positive regulation of immune system process;positive regulation of leukocyte migration;regulation of immune system process;regulation of leukocyte migration;response to stress;transport 10 10 10 6.4 6.4 6.4 213.7 3.5439E-51 62997000 41686000 21310000 4897 IPI:IPI00455473.2;IPI:IPI00739902.2;IPI:IPI00655578.3;IPI:IPI00741107.3 Melanoma inhibitory activity protein 3;Transport and Golgi organization protein 1;C219-reactive peptide;D320 MIA3;KIAA0268;UNQ6077/PRO20088 Q5JRA6-1;Q5JRA6;Q5JRA6-2;Q5JRA6-4 ENST00000344922 4 NaN 1.0143 0.69581 NaN 0.69815 0.92441 Prothymosin cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle biosynthetic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription 3 3 3 24.3 24.3 24.3 12.203 5.3285E-55 47451000 25274000 22177000 4898 IPI:IPI00827535.1;IPI:IPI00455510.4 Prothymosin alpha;Thymosin alpha-1 PTMA;TMSA P06454-1;P06454;P06454-2 ENST00000341369;ENST00000410064 2 0.60605 2.1301 0.83091 0.80539 1.3931 1.1398 DUF2392 cell part;cytoplasm;intracellular part binding;protein binding nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA processing;tRNA metabolic process;tRNA modification;tRNA processing;tRNA wobble base modification;tRNA wobble uridine modification 3 3 3 8.2 8.2 8.2 56.107 1.5748E-06 2590800 1765100 825680 4899 IPI:IPI00455719.3;IPI:IPI00848327.1 Cytoplasmic tRNA 2-thiolation protein 2 CTU2;C16orf84;NCS2 Q2VPK5-1;Q2VPK5;Q2VPK5-3 ENST00000312060;ENST00000378384 2 NaN 1.2268 0.76396 NaN 0.83418 0.97113 PH cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;nucleus;organelle;plasma membrane 2 2 2 5.2 5.2 5.2 47.254 3.5522E-11 7202300 3741200 3461100 4900 IPI:IPI00455835.1 Pleckstrin homology domain-containing family A member 2;Tandem PH domain-containing protein 2 PLEKHA2;TAPP2 Q9HB19 ENST00000388745 1 0.73217 1.5973 NaN 0.99183 0.98887 NaN HMG_box cell part;cytoplasmic part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding cell communication;cell surface receptor linked signal transduction;endosome to lysosome transport;lysosomal transport;negative regulation of signal transduction;regulation of signal transduction;signal transduction;transport;vacuolar transport 3 3 3 8.5 8.5 8.5 65.711 4.0706E-76 4428800 2341100 2087700 4901 IPI:IPI00455982.1 HMG domain-containing protein 4;HMG box-containing protein 4;High mobility group protein 2-like 1;Protein HMGBCG HMGXB4;HMG2L1;HMGBCG Q9UGU5 ENST00000216106 K11298 1 0.66106 1.5906 0.76941 0.87875 1.1326 0.98226 AAA;Bromodomain ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity 6 5 5 5.1 4.3 4.3 164.94 5.3082E-49 7898600 4162600 3736000 4902 IPI:IPI00739581.2;IPI:IPI00456004.4 ATPase family AAA domain-containing protein 2B ATAD2B;KIAA1240 Q9ULI0-1;Q9ULI0;Q9ULI0-2 ENST00000381024 2 0.79409 1.4682 0.58194 0.97255 1.0464 0.72709 HCaRG binding;protein binding 3 3 3 17.1 17.1 17.1 22.745 2.8736E-36 130880000 67014000 63865000 4903 IPI:IPI00456048.4 COMM domain-containing protein 2 COMMD2;HSPC042;My004 Q86X83 ENST00000232863 1 0.77145 1.4728 0.75791 1.0327 0.97647 1.0201 LsmAD;PAM2 cell part;membrane 22 22 22 25.1 25.1 25.1 113.37 2.9703E-304 887850000 459330000 428520000 4904 IPI:IPI00456359.1;IPI:IPI00456363.1;IPI:IPI00456361.3;IPI:IPI00456365.1;IPI:IPI00456367.3;IPI:IPI00456369.1;IPI:IPI00479363.3 Ataxin-2-like protein;Ataxin-2 domain protein;Ataxin-2-related protein ATXN2L;A2D;A2LG;A2LP;A2RP Q8WWM7-1;Q8WWM7;Q8WWM7-3;Q8WWM7-2;Q8WWM7-4;Q8WWM7-5;Q8WWM7-6;Q8WWM7-7 ENST00000325200;ENST00000325215;ENST00000336783;ENST00000340394;ENST00000359153;ENST00000395547 7 0.72441 1.4514 NaN 0.99665 0.94892 NaN centriole;ciliary rootlet;cilium part;cytoplasmic part;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;organelle;organelle part binding;cytoskeletal protein binding;kinesin binding;protein binding;structural molecule activity cell cycle;cell projection organization;cellular component organization;cellular process;centrosome organization;localization;macromolecule localization;microtubule organizing center organization;organelle organization;protein localization 5 5 5 3 3 3 228.52 1.252E-11 3857900 2112100 1745900 4905 IPI:IPI00456492.2;IPI:IPI00644892.4 Rootletin;Ciliary rootlet coiled-coil protein CROCC;KIAA0445 Q5TZA2-1;Q5TZA2 ENST00000375541 2 0.44367 0.92865 0.38584 0.5923 0.66652 0.51342 14 14 14 13.8 13.8 13.8 154.69 7.4876E-105 215090000 115230000 99855000 4906 IPI:IPI00456628.5 Leucine-rich repeat-containing protein 16C;RGD, leucine-rich repeat, tropomodulin and proline-rich containing protein RLTPR;LRRC16C Q6F5E8 ENST00000334583 1 0.73898 1.2912 0.71473 0.94055 0.85202 0.89904 Amino_oxidase;SWIRM adenyl nucleotide binding;binding;catalytic activity;coenzyme binding;cofactor binding;electron carrier activity;FAD binding;nucleoside binding;nucleotide binding;oxidoreductase activity;purine nucleoside binding;purine nucleotide binding chromatin organization;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;protein amino acid demethylation;protein modification process;transcription 18 18 18 27.5 27.5 27.5 92.902 0 485430000 256550000 228880000 4907 IPI:IPI00456631.5;IPI:IPI00217540.7 Lysine-specific histone demethylase 1;Flavin-containing amine oxidase domain-containing protein 2;BRAF35-HDAC complex protein BHC110 KDM1;AOF2;KIAA0601;LSD1 O60341-1;O60341;O60341-2 ENST00000246149;ENST00000356634 K11450 2 0.8049 1.2241 NaN 1.0483 0.88415 NaN APC10;HECT anaphase-promoting complex;cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nuclear ubiquitin ligase complex;organelle part;protein complex;ubiquitin ligase complex acid-amino acid ligase activity;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;protein binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;protein metabolic process;protein modification process;proteolysis;regulation of cell cycle process;regulation of mitosis;regulation of mitotic cell cycle 6 6 6 9.8 9.8 9.8 97.112 6.2983E-54 37702000 17933000 19769000 4909 IPI:IPI00456642.3 Probable E3 ubiquitin-protein ligase HECTD3;HECT domain-containing protein 3 HECTD3 Q5T447-1;Q5T447 ENST00000372172 K12233 1 0.71174 0.6329 0.4045 0.89383 0.45081 0.51335 F-box cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 5 5 5 5 5 5 125.96 5.0819E-40 23512000 12742000 10770000 4910 IPI:IPI00456677.2;IPI:IPI00456676.2;IPI:IPI00456678.4 F-box only protein 38;Modulator of KLF7 activity homolog FBXO38;SP329 Q6PIJ6-2;Q6PIJ6;Q6PIJ6-1;Q6PIJ6-3 ENST00000296701;ENST00000340253 K10313 3 1.1786 NaN NaN 1.618 NaN NaN centrosome;cytoplasmic part;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;microtubule organizing center;non-membrane-bounded organelle;organelle;organelle part 3 3 3 1.1 1.1 1.1 279.11 0.00015566 1172200 120570 1051600 4911 IPI:IPI00456708.5;IPI:IPI00940639.1 Centrosomal protein of 192 kDa CEP192;KIAA1569;PP8407 Q8TEP8-1;Q8TEP8;Q8TEP8-2 ENST00000325971 2 0.81816 1.6965 0.68423 0.97977 1.2202 0.84975 BAR;RhoGAP cell part;cytoplasm;intracellular part binding;enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity;protein binding;protein domain specific binding;SH3 domain binding biological regulation;cell communication;cellular process;regulation of biological process;regulation of cellular process;signal transduction 3 3 3 6.4 6.4 6.4 75.712 1.5947E-13 16699000 9266100 7432700 4912 IPI:IPI00456744.1;IPI:IPI00456745.4 SH3 domain-binding protein 1 SH3BP1 Q9Y3L3-1;Q9Y3L3;Q9Y3L3-2 ENST00000336738;ENST00000357436 2 NaN 1.5373 NaN NaN 1.1108 NaN 2 2 2 3.3 3.3 3.3 82.682 1.0359E-20 710150 429550 280600 4913 IPI:IPI00456750.2 Niban-like protein 1;Protein FAM129B;Meg-3 FAM129B;C9orf88 Q96TA1 ENST00000373312;ENST00000373314 1 0.72299 1.3266 0.65914 0.94141 0.92774 0.88138 L15 cell part;cytoplasmic part;cytosolic large ribosomal subunit;cytosolic part;intracellular organelle part;intracellular part;large ribosomal subunit;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit binding;nucleic acid binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 8 8 8 39.9 39.9 39.9 16.561 2.1263E-109 2798300000 1453800000 1344500000 4914 IPI:IPI00456758.4 60S ribosomal protein L27a RPL27A P46776 ENST00000314138 K02900 1 0.82595 1.6868 0.89934 1.147 1.0886 1.172 6 6 6 8 8 8 147.18 3.2828E-50 63180000 30838000 32342000 4915 IPI:IPI00792422.1;IPI:IPI00797872.4;IPI:IPI00514705.2;IPI:IPI00456853.3;IPI:IPI00556261.2;IPI:IPI00884375.2;IPI:IPI00745075.4 Protein FAM21A;Protein FAM21C;Protein FAM21B FAM21A;FAM21C;KIAA0592;FAM21B Q641Q2-1;Q641Q2;Q641Q2-2;Q9Y4E1-1;Q9Y4E1;Q9Y4E1-2;Q9Y4E1-3;Q5SNT6 ENST00000399339;ENST00000336378;ENST00000359860;ENST00000282633 7 0.78662 1.2685 0.84823 1.0481 0.82163 1.113 SAP;SPRY cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;protein binding 16 16 16 20.9 20.9 20.9 85.104 1.2289E-118 290170000 147750000 142420000 4916 IPI:IPI00456887.2 Heterogeneous nuclear ribonucleoprotein U-like protein 2;Scaffold-attachment factor A2 HNRNPUL2;HNRPUL2 Q1KMD3 ENST00000301785 1 0.99094 1.7897 0.9864 1.2862 1.1887 1.2576 zf-C3HC4 binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding 4 4 4 8.1 8.1 8.1 77.193 4.5308E-36 10189000 5253100 4935500 4917 IPI:IPI00456899.2 RING finger protein 169 RNF169;KIAA1991 Q8NCN4 ENST00000299563 1 0.54964 1.1226 0.53421 0.75487 0.70603 0.71304 Ribosomal_L30 cell part;cytoplasmic part;intracellular organelle part;intracellular part;large ribosomal subunit;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit binding;protein binding;structural constituent of ribosome;structural molecule activity;transcription regulator activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 10 10 10 35 35 35 28.661 7.0634E-132 304830000 169780000 135050000 4918 IPI:IPI00456940.5 60S ribosomal protein L7-like 1 RPL7L1 Q6DKI1 ENST00000304734;ENST00000372871 1 0.74611 1.4152 0.73142 0.97794 0.94865 0.95653 AAA_5;DHC_N1;DHC_N2;Dynein_heavy cytoplasmic dynein complex;dynein complex;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;microtubule;microtubule associated complex;organelle;protein complex ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;microtubule motor activity;motor activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity cellular component organization;cellular process;cytoskeleton organization;microtubule cytoskeleton organization;microtubule-based movement;microtubule-based process;mitotic spindle organization;organelle organization;spindle organization 178 178 178 43.2 43.2 43.2 532.4 0 8280100000 4569000000 3711100000 4920 IPI:IPI00456969.1 Cytoplasmic dynein 1 heavy chain 1;Cytoplasmic dynein heavy chain 1;Dynein heavy chain, cytosolic DYNC1H1;DHC1;DNCH1;DNCL;DNECL;DYHC;KIAA0325 Q14204 ENST00000360184 K10413 1 0.73187 1.6169 0.76799 0.99 1.0308 1.0741 4 4 4 3.7 3.7 3.7 164.2 5.4126E-16 23982000 12864000 11119000 4923 IPI:IPI00457284.2;IPI:IPI00942874.1;IPI:IPI00328308.7;IPI:IPI00375560.4 G patch domain-containing protein 8 GPATCH8;GPATC8;KIAA0553 Q9UKJ3-1;Q9UKJ3;Q9UKJ3-2 ENST00000335500 4 0.77248 1.6663 0.94198 0.98222 1.1752 1.2248 RRM_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 6 6 6 18.8 18.8 18.8 53.542 2.1506E-97 677300000 352770000 324530000 4924 IPI:IPI00464952.2 Splicing factor, arginine/serine-rich 11;Arginine-rich 54 kDa nuclear protein;p54 SFRS11 Q05519 ENST00000370950;ENST00000405432 1 0.52308 1.2659 NaN 0.69201 0.79767 NaN binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding 4 4 4 3.5 3.5 3.5 161.74 6.6708E-07 5771500 3371900 2399600 4926 IPI:IPI00464985.5;IPI:IPI00549242.2 Vacuolar protein sorting-associated protein 8 homolog VPS8;KIAA0804 Q8N3P4-1;Q8N3P4;Q8N3P4-2 ENST00000287546 2 0.61668 1.3676 0.6402 0.81056 0.85381 0.85188 MMR_HSR1;TrmE_N cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleotide binding;pyrophosphatase activity cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA modification;RNA processing;tRNA metabolic process;tRNA modification;tRNA processing 4 4 4 9.2 9.2 9.2 55.533 2.2862E-08 10985000 6488300 4496600 4927 IPI:IPI00783945.2;IPI:IPI00464994.7;IPI:IPI00644024.2 tRNA modification GTPase GTPBP3, mitochondrial;GTP-binding protein 3;Mitochondrial GTP-binding protein 1 GTPBP3;MTGP1 Q969Y2-2;Q969Y2;Q969Y2-1;Q969Y2-3 ENST00000324894;ENST00000358792 K03650 3 0.30646 NaN 0.22875 0.40954 NaN 0.32176 HEAT binding 3 3 3 3.6 3.6 3.6 128.78 1.2381E-94 1384900 897010 487880 4928 IPI:IPI00464999.2 HEAT repeat-containing protein 6;Amplified in breast cancer protein 1 HEATR6;ABC1 Q6AI08 ENST00000184956 1 0.61078 1.2226 0.56526 0.82617 0.78848 0.75751 HATPase_c;SMC_hinge cell part;chromosome;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cellular component organization;cellular process;chromosome organization;organelle organization 28 28 28 16.3 16.3 16.3 226.37 1.1758E-285 449210000 252790000 196430000 4929 IPI:IPI00890837.1;IPI:IPI00465022.9;IPI:IPI00645162.3 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 SMCHD1;KIAA0650 A6NHR9-1;A6NHR9;A6NHR9-2 ENST00000261598 3 NaN 0.47103 0.13491 NaN 0.32393 0.17408 LRR_1 centrosome;cytoplasmic part;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;microtubule organizing center;non-membrane-bounded organelle;organelle;organelle part 2 2 2 3.4 3.4 3.4 71.717 0.00018025 5574000 4858600 715350 4930 IPI:IPI00465040.3;IPI:IPI00910558.1 Centrosomal protein of 72 kDa CEP72;KIAA1519 Q9P209-1;Q9P209;Q9P209-2 ENST00000264935 2 0.53878 0.97252 0.51572 0.67831 0.66849 0.66529 RCC1 chromosomal part;chromosome, centromeric region;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;microtubule;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;spindle cell cycle phase;cell cycle process;cell division;cellular component organization;cellular process;mitosis;nuclear division;organelle fission;organelle organization 30 30 30 58.2 58.2 58.2 56.084 0 4924000000 2712200000 2211800000 4931 IPI:IPI00465044.2;IPI:IPI00022997.1 Protein RCC2;Telophase disk protein of 60 kDa;RCC1-like protein TD-60 RCC2;KIAA1470;TD60 Q9P258 ENST00000375433;ENST00000375436 2 0.64884 0.89409 0.56837 0.87332 0.60316 0.78385 AMP-binding;DMAP_binding cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;protein binding;transcription factor binding metabolic process 12 12 11 11.4 11.4 10.7 171.49 9.8268E-104 39133000 21323000 17810000 4932 IPI:IPI00465045.2;IPI:IPI00643040.4 Disco-interacting protein 2 homolog B DIP2B;KIAA1463 Q9P265-1;Q9P265 ENST00000301180 2 NaN 1.4455 0.4257 NaN 1.0207 0.54504 EF_assoc_1;EF_assoc_2;Miro integral to membrane;integral to mitochondrial membrane;integral to mitochondrial outer membrane;integral to organelle membrane;intrinsic to membrane;intrinsic to mitochondrial outer membrane;intrinsic to organelle membrane;organelle part binding;calcium ion binding;catalytic activity;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;hydrolase activity;nucleotide binding;protein binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding apoptosis;cell communication;cell death;cellular process;intracellular signaling cascade;microtubule-based movement;microtubule-based process;microtubule-based transport;signal transduction;small GTPase mediated signal transduction;transport 3 2 2 5.2 3.4 3.4 68.117 3.7729E-37 574660 358030 216630 4933 IPI:IPI00465059.4 Mitochondrial Rho GTPase 2;Ras homolog gene family member T2 RHOT2;ARHT2;C16orf39 Q8IXI1-1;Q8IXI1 ENST00000315082 K07871 1 0.6733 1.3942 0.81675 0.89211 0.89368 1.0578 Histone cell part;chromosomal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;macromolecular complex;membrane-bounded organelle;nucleosome;nucleus;organelle;organelle part;protein-DNA complex binding;DNA binding;nucleic acid binding;protein binding anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;chromatin organization;nucleosome assembly;organelle organization Systemic lupus erythematosus 7 1 1 45.6 23.5 23.5 15.404 1.9494E-96 1497900000 762120000 735750000 4934 IPI:IPI00465070.7 Histone H3.1;H3/a;H3/b;H3/c;H3/d;H3/f;H3/h;H3/i;H3/j;H3/k;H3/l HIST1H3A;H3FA;HIST1H3B;H3FL;HIST1H3C;H3FC;HIST1H3D;H3FB;HIST1H3E;H3FD;HIST1H3F;H3FI;HIST1H3G;H3FH;HIST1H3H;H3FK;HIST1H3I;H3FF;HIST1H3J;H3FJ P68431 ENST00000230495;ENST00000244661;ENST00000321285;ENST00000328488;ENST00000356476;ENST00000357647;ENST00000359303;ENST00000360408;ENST00000360577;ENST00000369163;ENST00000369387;ENST00000377831 K11253 1 0.65361 1.2597 0.66767 0.8183 0.87342 0.83896 NAPRTase cell part;cytoplasmic part;cytosol;intracellular part catalytic activity;nicotinate phosphoribosyltransferase activity;transferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring pentosyl groups coenzyme metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;oxidoreduction coenzyme metabolic process;vitamin metabolic process;water-soluble vitamin metabolic process 7 7 7 13.1 13.1 13.1 60.291 5.8524E-70 35891000 19839000 16052000 4935 IPI:IPI00879716.1;IPI:IPI00465085.3;IPI:IPI00880164.1 Nicotinate phosphoribosyltransferase;Nicotinate phosphoribosyltransferase domain-containing protein 1;FHA-HIT-interacting protein NAPRT1;FHIP Q6XQN6-2;Q6XQN6;Q6XQN6-1;Q6XQN6-3 ENST00000276844 3 0.75999 NaN 0.46736 0.98114 NaN 0.61585 Peptidase_C12 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;cysteine-type peptidase activity;hydrolase activity;hydrolase activity, acting on ester bonds;peptidase activity;protein binding;thiolester hydrolase activity;ubiquitin thiolesterase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;negative regulation of cell proliferation;protein metabolic process;protein modification process;proteolysis;ubiquitin-dependent protein catabolic process 3 3 3 4.9 4.9 4.9 80.361 0.0025227 21756000 11518000 10237000 4936 IPI:IPI00465087.2 Ubiquitin carboxyl-terminal hydrolase BAP1;BRCA1-associated protein 1;Cerebral protein 6 BAP1;KIAA0272;hucep-6 Q92560 ENST00000296288 K08588 1 0.71155 1.1718 0.67083 0.9038 0.82727 0.81222 ubiquitin cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding 20 20 20 27.2 27.2 27.2 122.34 8.4306E-280 741620000 385050000 356570000 4938 IPI:IPI00645431.2;IPI:IPI00465128.4;IPI:IPI00640922.1;IPI:IPI00743888.2;IPI:IPI00760551.1;IPI:IPI00026669.1 Large proline-rich protein BAT3;HLA-B-associated transcript 3;Protein G3 BAT3;G3 P46379-3;P46379;P46379-1;P46379-2 ENST00000361076;ENST00000362049;ENST00000375964;ENST00000375976;ENST00000383254;ENST00000404765 6 0.66116 1.3558 0.63841 0.83155 0.87946 0.82612 Coatomer_E cell part;COPI vesicle coat;cytoplasmic part;cytoplasmic vesicle part;cytosol;Golgi apparatus part;intracellular organelle part;intracellular part;macromolecular complex;membrane coat;membrane part;organelle part;protein complex;vesicle coat binding;protein binding;structural molecule activity cellular component organization;cellular process;intra-Golgi vesicle-mediated transport;organelle organization;protein transport;retrograde vesicle-mediated transport, Golgi to ER;transport;vesicle coating;vesicle organization;vesicle-mediated transport 16 16 16 59.4 59.4 59.4 34.482 0 724410000 378190000 346220000 4939 IPI:IPI00465132.4 Coatomer subunit epsilon;Epsilon-coat protein COPE O14579 ENST00000262812 1 NaN 1.1689 NaN NaN 0.75193 NaN C2 binding;protein binding 3 3 3 3.9 3.9 3.9 121.46 7.1727E-27 6175000 3578900 2596000 4940 IPI:IPI00783895.4;IPI:IPI00465142.2 Uncharacterized protein KIAA0528 KIAA0528 Q86YS7-2;Q86YS7;Q86YS7-1 ENST00000333957;ENST00000396028 2 0.80363 1.4379 0.78696 0.97439 0.95883 1.0324 ABC_tran ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity 17 17 17 25.2 25.2 25.2 79.744 6.7919E-109 164670000 86188000 78481000 4943 IPI:IPI00465160.4;IPI:IPI00784776.1 ATP-binding cassette sub-family F member 3 ABCF3 Q9NUQ8-1;Q9NUQ8;Q9NUQ8-2 ENST00000292808 K06158 2 0.64099 1.5399 0.62069 0.86544 0.91295 0.80686 5_nucleotid binding;catalytic activity;cation binding;hydrolase activity;ion binding;magnesium ion binding;metal ion binding 8 8 8 17.9 17.9 17.9 63.419 1.2813E-29 14954000 8146900 6806700 4945 IPI:IPI00465170.1;IPI:IPI00642386.5 5'-nucleotidase domain-containing protein 3;Grp94-neighboring nucleotidase NT5DC3;GNN;TU12B1-TY Q86UY8-1;Q86UY8;Q86UY8-2 ENST00000339146;ENST00000392876 2 0.59098 NaN NaN 0.85548 NaN NaN intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;mitochondrion;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 2 2 2 19.9 19.9 19.9 21.838 3.5889E-11 1393300 835400 557870 4946 IPI:IPI00465176.2;IPI:IPI00748207.3;IPI:IPI00807606.1 39S ribosomal protein L30, mitochondrial;MRP-L30;MRP-L28 MRPL30;MRPL28;RPML28;HSPC249 Q8TCC3-2;Q8TCC3;Q8TCC3-1;Q8TCC3-3 ENST00000308644;ENST00000308656;ENST00000338148;ENST00000409841 3 NaN 1.6249 0.22766 NaN 1.1715 0.28458 DUF1167 centrosome;Golgi apparatus;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;microtubule;microtubule organizing center;non-membrane-bounded organelle;nucleus;organelle binding;fibroblast growth factor binding;growth factor binding;identical protein binding;protein binding;protein dimerization activity;protein homodimerization activity cell communication;cell surface receptor linked signal transduction;enzyme linked receptor protein signaling pathway;intracellular protein transport;protein import into nucleus, translocation;signal transduction;transport 2 2 2 4.4 4.4 4.4 57.088 9.786E-17 8569400 5585100 2984200 4947 IPI:IPI00465200.2;IPI:IPI00943523.1;IPI:IPI00005700.4;IPI:IPI00514128.1 Centrosomal protein of 57 kDa;Testis-specific protein 57;Translokin;FGF2-interacting protein CEP57;KIAA0092;TSP57 Q86XR8-1;Q86XR8;Q86XR8-4;Q86XR8-2;Q86XR8-3 ENST00000325486;ENST00000325542 4 0.90443 1.7905 1.0844 1.2386 1.0951 1.5288 cell part;integral to membrane;intrinsic to membrane;membrane part 6 6 6 7.9 7.9 7.9 111.26 8.2325E-16 27799000 13534000 14265000 4948 IPI:IPI00465238.3;IPI:IPI00872797.1 UPF0505 protein C16orf62;Esophageal cancer-associated protein C16orf62;101F10.2 Q7Z3J2-1;Q7Z3J2;Q7Z3J2-2 ENST00000251143 2 0.75649 1.4429 0.73094 0.98011 0.94549 0.9704 Enolase_C;Enolase_N cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;M band;macromolecular complex;membrane;membrane-bounded organelle;nucleus;organelle;phosphopyruvate hydratase complex;plasma membrane;protein complex catalytic activity;DNA binding;endopeptidase activity;magnesium ion binding;nucleic acid binding;serine-type endopeptidase activity;transcription cofactor activity;transcription corepressor activity;transcription factor activity alcohol metabolic process;carbohydrate metabolic process;glucose catabolic process;glucose metabolic process;monosaccharide metabolic process;negative regulation of transcription from RNA polymerase II promoter;regulation of cell growth Glycolysis / Gluconeogenesis 32 32 28 77.9 77.9 69.4 47.168 0 36044000000 19125000000 16919000000 4949 IPI:IPI00465248.5;IPI:IPI00759806.1 Alpha-enolase;2-phospho-D-glycerate hydro-lyase;Non-neural enolase;Enolase 1;Phosphopyruvate hydratase;C-myc promoter-binding protein;MBP-1;MPB-1;Plasminogen-binding protein ENO1;ENO1L1;MBPB1;MPB1 P06733-1;P06733;P06733-2 ENST00000234590 K01689 2 0.66887 1.4136 0.86809 0.82654 0.89666 1.1439 ADK;ADK_lid cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part adenylate kinase activity;ATP binding;binding;catalytic activity;GTP binding;kinase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups cellular metabolic process;cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;primary metabolic process Pyrimidine metabolism 4 4 4 21.1 21.1 21.1 25.565 1.8763E-42 25717000 13524000 12193000 4950 IPI:IPI00465256.4 GTP:AMP phosphotransferase mitochondrial;Adenylate kinase 3;Adenylate kinase 3 alpha-like 1 AK3;AK3L1;AK6;AKL3L Q9UIJ7 ENST00000381809 K00944 1 1.1117 1.958 NaN 1.4624 1.3278 NaN Peptidase_M1 endoplasmic reticulum lumen;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;membrane-enclosed lumen;organelle lumen;organelle membrane;organelle part aminopeptidase activity;binding;catalytic activity;cation binding;exopeptidase activity;hydrolase activity;ion binding;metal ion binding;metallopeptidase activity;peptidase activity;transition metal ion binding;zinc ion binding antigen processing and presentation of endogenous peptide antigen;antigen processing and presentation of peptide antigen via MHC class I;catabolic process;immune response;immune system process;metabolic process;proteolysis;regulation of blood pressure 6 6 6 7.3 7.3 7.3 110.46 3.2104E-55 7556600 4083300 3473300 4951 IPI:IPI00465261.2;IPI:IPI00747807.1;IPI:IPI00877711.1;IPI:IPI00878267.1 Endoplasmic reticulum aminopeptidase 2;Leukocyte-derived arginine aminopeptidase ERAP2;LRAP Q6P179-1;Q6P179;Q6P179-3;Q6P179-2;Q6P179-4 ENST00000343361;ENST00000379904 4 0.84278 1.4614 0.73559 1.1135 0.92922 0.99706 LisH;RanBPM_CRA;SPRY cytoplasm;cytoskeletal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;microtubule associated complex;nucleus;organelle;organelle part;protein complex binding;enzyme binding;GTPase binding;protein binding;Ran GTPase binding;Ras GTPase binding;small GTPase binding anatomical structure formation;cellular component organization;cellular process;cytoskeleton organization;microtubule cytoskeleton organization;microtubule nucleation;microtubule-based process;organelle organization;protein complex assembly 8 8 6 16.5 16.5 10.7 77.846 1.5478E-71 138950000 75536000 63413000 4952 IPI:IPI00465275.2;IPI:IPI00554545.1 Ran-binding protein 9;RanBP7;Ran-binding protein M;BPM90;BPM-L RANBP9;RANBPM Q96S59-1;Q96S59;Q96S59-2 ENST00000011619 2 NaN 1.4534 0.68792 NaN 0.98086 0.97499 zf-C2H2 cell part;cytoplasm;intracellular organelle part;intracellular part;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;transcription activator activity;transcription regulator activity;transition metal ion binding;zinc ion binding nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent 4 4 4 3.3 3.3 3.3 187.55 5.1055E-62 8063700 4068500 3995200 4953 IPI:IPI00465288.2;IPI:IPI00465287.2;IPI:IPI00853192.1;IPI:IPI00853504.1 Ras-responsive element-binding protein 1;Raf-responsive zinc finger protein LZ321;Zinc finger motif-enhancer binding-protein 1;Finger protein in nuclear bodies RREB1;FINB Q92766-2;Q92766;Q92766-1;Q92766-4 ENST00000334984;ENST00000349384;ENST00000379933 4 0.81314 1.6256 0.86051 1.1055 1.0743 1.1354 Myb_DNA-binding cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;nuclear body;nuclear speck;nucleolus;organelle;organelle part;ribonucleoprotein complex;spliceosomal complex binding;DNA binding;nucleic acid binding;protein binding;RNA binding cell cycle;metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;RNA processing;RNA splicing;transcription 20 20 20 26.9 26.9 26.9 92.25 1.25E-77 651950000 344140000 307810000 4955 IPI:IPI00465294.2 Cell division cycle 5-like protein;Pombe cdc5-related protein CDC5L;KIAA0432;PCDC5RP Q99459 ENST00000371477 1 0.47705 1.075 0.3847 0.60068 0.74444 0.47799 IBN_N;Xpo1 cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;organelle part;pore complex;protein complex binding;protein binding;protein transporter activity;substrate-specific transporter activity;transporter activity anatomical structure formation;cellular process;intracellular protein transport;nucleocytoplasmic transport;protein complex assembly;protein export from nucleus;protein import into nucleus, docking;protein targeting;protein transport;transport 4 4 4 3.8 3.8 3.8 128.88 6.5214E-29 5066400 3057600 2008700 4956 IPI:IPI00465296.2 Exportin-6;Ran-binding protein 20 XPO6;KIAA0370;RANBP20 Q96QU8 ENST00000304658 1 0.79479 1.9755 NaN 1.0707 1.3192 NaN PIG-S cell part;cytoplasmic part;endoplasmic reticulum part;GPI-anchor transamidase complex;intracellular organelle part;intracellular part;macromolecular complex;membrane part;organelle part;protein complex binding;protein binding attachment of GPI anchor to protein;biopolymer metabolic process;biopolymer modification;cellular biopolymer metabolic process;cellular process;macromolecule metabolic process;metabolic process;protein metabolic process;protein modification process Glycosylphosphatidylinositol(GPI)-anchor biosynthesis 8 8 8 20.5 20.5 20.5 61.655 2.1848E-109 25665000 14617000 11047000 4957 IPI:IPI00465308.3;IPI:IPI00554703.1 GPI transamidase component PIG-S;Phosphatidylinositol-glycan biosynthesis class S protein PIGS;UNQ1873/PRO4316 Q96S52-1;Q96S52;Q96S52-2 ENST00000308360 K05291 2 0.78911 1.639 0.7996 1.0123 1.0823 1.0549 Cytochrom_C cytosol;macromolecular complex;membrane-enclosed lumen;mitochondrial intermembrane space;mitochondrial matrix;nucleus;organelle;organelle envelope lumen;protein phosphatase type 2A complex;protein serine/threonine phosphatase complex binding;cation binding;electron carrier activity;electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity;heme binding;ion binding;iron ion binding;metal ion binding;protein binding DNA catabolic process;DNA catabolic process, endonucleolytic;DNA fragmentation involved in apoptosis;DNA metabolic process;generation of precursor metabolites and energy;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Alzheimer's disease;Amyotrophic lateral sclerosis (ALS);Apoptosis;Colorectal cancer;Huntington's disease;p53 signaling pathway;Parkinson's disease;Pathways in cancer;Small cell lung cancer 5 5 5 55.2 55.2 55.2 11.749 3.0478E-75 1120600000 602690000 517890000 4958 IPI:IPI00465315.6;IPI:CON_CytC Cytochrome c CYCS;CYC P99999 ENST00000305786;ENST00000409409;ENST00000409764 K08738 2 0.77445 1.2543 0.77277 0.94798 0.88583 0.9732 Ribosomal_L13e cell part;cytoplasmic part;cytosolic part;cytosolic ribosome;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome binding;nucleic acid binding;protein binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 12 12 12 45 45 45 24.261 4.1991E-151 4655500000 2426500000 2229100000 4960 IPI:IPI00465361.4 60S ribosomal protein L13;Breast basic conserved protein 1 RPL13;BBC1;OK/SW-cl.46 P26373 ENST00000311528;ENST00000393099 K02873 1 0.80216 NaN 0.57638 1.0312 NaN 0.69437 CBFD_NFYB_HMF condensed chromosome kinetochore;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;kinetochore;macromolecular complex;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;sequence-specific DNA binding 2 2 2 4.6 4.6 4.6 60.422 7.6047E-07 193820000 103520000 90301000 4961 IPI:IPI00465368.4;IPI:IPI00643513.2;IPI:IPI00787249.1 Centromere protein T;Interphase centromere complex protein 22 CENPT;C16orf56;ICEN22 Q96BT3-1;Q96BT3;Q96BT3-2;Q96BT3-3 ENST00000219172 K11512 3 0.83197 1.3372 0.85813 1.0397 0.93 1.0591 Aminotran_1_2 binding;carbon-sulfur lyase activity;catalytic activity;kynurenine-oxoglutarate transaminase activity;lipid binding;lyase activity;steroid binding;transaminase activity;transferase activity;transferase activity, transferring nitrogenous groups biosynthetic process;metabolic process 6 6 6 16.1 16.1 16.1 51.4 6.3576E-23 110180000 60050000 50134000 4962 IPI:IPI00465373.2;IPI:IPI00465006.2 Kynurenine--oxoglutarate transaminase 3;Kynurenine--oxoglutarate transaminase III;Kynurenine aminotransferase III;Cysteine-S-conjugate beta-lyase 2 CCBL2;KAT3;RBMXL1 Q6YP21-1;Q6YP21 ENST00000260508;ENST00000370485 2 0.571 1.5643 0.57698 0.7974 1.1079 0.78063 cell part;cytoplasm;intracellular part binding;protein binding cell communication;cell surface receptor linked signal transduction;cellular process;integrin-mediated signaling pathway;intracellular signaling cascade;MAPKKK cascade;protein kinase cascade;response to stress;signal transduction;vasculogenesis 3 3 3 8.3 8.3 8.3 48.836 5.6413E-06 7832000 4725900 3106100 4963 IPI:IPI00465425.3;IPI:IPI00945844.1 Malcavernin;Cerebral cavernous malformations 2 protein CCM2;C7orf22;PP10187 Q9BSQ5-1;Q9BSQ5;Q9BSQ5-2 ENST00000258781;ENST00000381112 2 0.56725 1.0284 0.54826 0.72995 0.69252 0.70237 DUF1162 localization;macromolecule localization;protein localization 37 37 37 11.8 11.8 11.8 422.39 3.8919E-264 426980000 236990000 189990000 4964 IPI:IPI00465428.2;IPI:IPI00797358.2;IPI:IPI00942695.1;IPI:IPI00604778.1 Vacuolar protein sorting-associated protein 13C VPS13C;KIAA1421 Q709C8-1;Q709C8;Q709C8-3;Q709C8-2;Q709C8-4 ENST00000249837;ENST00000261517;ENST00000395896 4 0.75942 1.6998 0.83442 1.0214 1.0996 1.053 Catalase;Catalase-rel intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;microbody;microbody membrane;microbody part;organelle;organelle membrane;organelle part;peroxisomal membrane;peroxisomal part antioxidant activity;binding;catalase activity;catalytic activity;growth factor activity;iron ion binding;nucleotide binding;oxidoreductase activity;peroxidase activity;protein binding;receptor binding catabolic process;cell proliferation;metabolic process;oxygen and reactive oxygen species metabolic process;protein complex assembly;response to oxidative stress;response to radiation;response to reactive oxygen species;response to stress;response to UV Amyotrophic lateral sclerosis (ALS);Methane metabolism;Tryptophan metabolism 18 18 18 38.9 38.9 38.9 59.755 4.3961E-181 605180000 323630000 281550000 4965 IPI:IPI00465436.4 Catalase CAT P04040 ENST00000241052 K03781 1 0.79803 1.4341 0.76299 1.0315 0.93912 1.0005 Glycolytic actin cytoskeleton;cytoskeleton;extracellular organelle;I band;intracellular membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;membrane-bounded vesicle;non-membrane-bounded organelle;nucleus;organelle;vesicle actin binding;aldehyde-lyase activity;binding;carbohydrate binding;carbon-carbon lyase activity;catalytic activity;cytoskeletal protein binding;fructose-bisphosphate aldolase activity;lyase activity;protein binding;sugar binding;tubulin binding alcohol metabolic process;carbohydrate metabolic process;fructose metabolic process;generation of precursor metabolites and energy;glucose catabolic process;glucose metabolic process;monosaccharide metabolic process;muscle system process;system process Carbon fixation in photosynthetic organisms;Fructose and mannose metabolism;Glycolysis / Gluconeogenesis;Pentose phosphate pathway 29 29 26 80.2 80.2 70.6 39.42 0 17174000000 8878200000 8296100000 4966 IPI:IPI00465439.5;IPI:IPI00218407.6 Fructose-bisphosphate aldolase A;Muscle-type aldolase;Lung cancer antigen NY-LU-1 ALDOA;ALDA P04075 ENST00000338110;ENST00000395240;ENST00000395248 K01623 2 0.71521 1.4318 0.72798 0.98273 0.93772 1.0211 PAP_assoc cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle ATP binding;binding;catalytic activity;nucleic acid binding;nucleoside binding;nucleotide binding;polynucleotide adenylyltransferase activity;purine nucleoside binding;RNA binding;transferase activity biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA processing;transcription 10 10 9 18.8 18.8 17.4 78.832 5.3367E-76 148050000 79119000 68926000 4968 IPI:IPI00470416.2;IPI:IPI00153051.5 Poly(A) RNA polymerase, mitochondrial;mtPAP;Polynucleotide adenylyltransferase;PAP-associated domain-containing protein 1 MTPAP;PAPD1 Q9NVV4-2;Q9NVV4;Q9NVV4-1 ENST00000263063;ENST00000358107 2 0.91969 1.5832 0.78673 1.2225 1.1123 1.0274 FAD_binding_1;Flavodoxin_1;NAD_binding_1 cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;intracellular organelle part;intracellular part;membrane;membrane part;organelle membrane;organelle part binding;catalytic activity;electron carrier activity;FMN binding;iron ion binding;NADPH-hemoprotein reductase activity;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;sugar binding metabolic process;oxidation reduction 10 10 10 21.1 21.1 21.1 76.689 4.6168E-115 113310000 56522000 56792000 4969 IPI:IPI00470467.5 NADPH--cytochrome P450 reductase POR;CYPOR P16435 ENST00000265302 K00327 1 0.40281 0.81966 0.62727 0.53169 0.55016 0.83388 WD40 6 6 6 4.2 4.2 4.2 165.95 8.9908E-106 38980000 20640000 18341000 4970 IPI:IPI00470483.17;IPI:IPI00654823.3;IPI:IPI00644445.4 WD repeat-containing protein 62 WDR62;C19orf14 O43379-1;O43379 ENST00000270301;ENST00000378860;ENST00000388999;ENST00000401500 3 0.93289 NaN 0.58766 1.2015 NaN 0.74122 DUF1518;HLH;Nuc_rec_co-act;PAS;SRC-1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;histone acetyltransferase activity;lysine N-acetyltransferase activity;N-acetyltransferase activity;protein binding;receptor binding;signal transducer activity;transcription coactivator activity;transcription cofactor activity biosynthetic process;cell communication;intracellular signaling cascade;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;signal transduction;transcription 2 2 1 1.4 1.4 1 156.75 0.0051614 6382100 3791600 2590500 4971 IPI:IPI00470490.2;IPI:IPI00470492.2;IPI:IPI00470491.3 Nuclear receptor coactivator 1;Steroid receptor coactivator 1;RIP160;Protein Hin-2;Renal carcinoma antigen NY-REN-52 NCOA1;SRC1 Q15788-1;Q15788;Q15788-3;Q15788-2 ENST00000288599;ENST00000348332;ENST00000406961 K09101 3 0.68312 1.3176 0.72462 0.9247 0.88678 0.92246 Ribosomal_L15e cell part;cytoplasmic part;cytosol;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome binding;nucleic acid binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 9 9 9 41.7 41.7 41.7 24.146 4.5259E-149 3761300000 1935400000 1826000000 4972 IPI:IPI00470528.5 60S ribosomal protein L15 RPL15;EC45;TCBAP0781 P61313 ENST00000307839;ENST00000354811 K02877 1 0.63473 1.1105 0.57862 0.84488 0.74062 0.76158 ARID cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transition metal ion binding;zinc ion binding biosynthetic process;chromatin organization;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;regulation of transcription, DNA-dependent;transcription 9 9 9 7.7 7.7 7.7 197.39 7.0919E-73 128280000 71986000 56298000 4973 IPI:IPI00470537.2;IPI:IPI00647133.1;IPI:IPI00444237.6 AT-rich interactive domain-containing protein 2;ARID domain-containing protein 2;BRG1-associated factor 200;Zinc finger protein with activation potential;Zipzap/p200 ARID2;KIAA1557 Q68CP9-1;Q68CP9;Q68CP9-3 ENST00000334344;ENST00000338636 K11765 3 0.4691 1.1092 0.49002 0.65698 0.72449 0.65859 LRR_1 binding;protein binding 5 5 5 27.2 27.2 27.2 26.754 2.6448E-18 27281000 16112000 11169000 4974 IPI:IPI00470576.4 Leucine-rich repeat-containing protein 57 LRRC57 Q8N9N7 ENST00000323443;ENST00000397130 1 NaN 1.4929 NaN NaN 0.96605 NaN 2 2 2 17.8 17.8 17.8 16.997 0.0020497 19211000 11817000 7393900 4976 IPI:IPI00470594.1;IPI:IPI00855711.1;IPI:IPI00855815.1;IPI:IPI00855947.1 UPF0485 protein C1orf144;Putative MAPK-activating protein PM18/PM20/PM22 C1orf144 Q7Z422-1;Q7Z422;Q7Z422-3;Q7Z422-4;Q7Z422-2 ENST00000375590;ENST00000401089 4 0.7414 1.2419 0.65336 0.95219 0.84624 0.88051 RRM_1 cell part;cytoplasm;intracellular organelle part;intracellular part;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part binding;cation binding;DNA binding;double-stranded DNA binding;ion binding;metal ion binding;nucleic acid binding;RNA binding;structure-specific DNA binding;transition metal ion binding;zinc ion binding cellular biopolymer metabolic process;cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 11 11 11 7.4 7.4 7.4 220.62 3.936E-144 34008000 18051000 15957000 4977 IPI:IPI00470596.3;IPI:IPI00607784.1;IPI:IPI00178953.3;IPI:IPI00916798.2;IPI:IPI00607679.1 Zinc finger protein 638;Zinc finger matrin-like protein;Nuclear protein 220;Cutaneous T-cell lymphoma-associated antigen se33-1;CTCL tumor antigen se33-1 ZNF638;NP220;ZFML Q14966-1;Q14966;Q14966-3;Q14966-4;Q14966-2 ENST00000264447;ENST00000355812;ENST00000377802;ENST00000409544 5 0.70931 1.7359 NaN 0.99627 1.1245 NaN UPF0020 binding;catalytic activity;methyltransferase activity;nucleic acid binding;transferase activity;transferase activity, transferring one-carbon groups cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;one-carbon metabolic process;RNA metabolic process;RNA processing;tRNA metabolic process;tRNA processing Aminophosphonate metabolism;Androgen and estrogen metabolism;Histidine metabolism;Naphthalene and anthracene degradation;Selenoamino acid metabolism;Tyrosine metabolism 4 4 4 9.3 9.3 9.3 53.42 3.2216E-11 22547000 13125000 9422500 4978 IPI:IPI00470606.3;IPI:IPI00741576.1;IPI:IPI00644082.1 tRNA guanosine-2'-O-methyltransferase TRM11 homolog TRMT11;C6orf75;MDS024 Q7Z4G4-1;Q7Z4G4;Q7Z4G4-2;Q7Z4G4-3 ENST00000334379;ENST00000368333 K00599 3 0.73567 1.5985 0.71286 0.99166 1.0264 0.93229 F420_oxidored binding;catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on the CH-NH group of donors;oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor;pyrroline-5-carboxylate reductase activity cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;metabolic process;nitrogen compound metabolic process;organic acid metabolic process;proline biosynthetic process;proline metabolic process Arginine and proline metabolism 11 10 10 47.2 43.1 43.1 33.637 5.0308E-238 596320000 319180000 277150000 4979 IPI:IPI00470610.4 Pyrroline-5-carboxylate reductase 2 PYCR2 Q96C36 ENST00000343818 K00286 1 0.86039 1.551 0.96149 1.074 1.1076 1.1877 G-gamma extrinsic to membrane;extrinsic to plasma membrane;Golgi apparatus;heterotrimeric G-protein complex;intracellular membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;organelle;protein complex molecular transducer activity;signal transducer activity cell communication;cellular process;cellular response to hormone stimulus;hormone-mediated signaling;intracellular signaling cascade;response to endogenous stimulus;response to hormone stimulus;response to organic substance;signal transduction Chemokine signaling pathway 2 2 2 36.6 36.6 36.6 7.8501 1.4415E-20 196110000 88463000 107650000 4980 IPI:IPI00470619.4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2;G gamma-I GNG2 P59768 ENST00000335281 K07826 1 0.61568 NaN 0.77625 0.79136 NaN 0.9767 COQ9 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle biosynthetic process;cellular ketone metabolic process;cellular process;coenzyme biosynthetic process;coenzyme metabolic process;metabolic process;oxidoreduction coenzyme metabolic process;ubiquinone biosynthetic process;ubiquinone metabolic process 2 2 2 6.9 6.9 6.9 35.509 0.00057874 40550000 21783000 18768000 4981 IPI:IPI00470631.2;IPI:IPI00385901.1 Ubiquinone biosynthesis protein COQ9, mitochondrial COQ9;C16orf49;HSPC326;PSEC0129 O75208-1;O75208;O75208-2 ENST00000262507 2 0.56544 0.97656 0.46169 0.76264 0.63612 0.61792 3 3 3 11.9 11.9 11.9 32.766 2.268E-05 32362000 17316000 15046000 4982 IPI:IPI00845227.1;IPI:IPI00470641.5;IPI:IPI00646945.2;IPI:IPI00845239.1 Uncharacterized protein C1orf131 C1orf131 Q8NDD1-1;Q8NDD1;Q8NDD1-2;Q8NDD1-3 ENST00000366649 4 0.77336 1.5651 0.75841 0.95974 1.0919 0.93541 Nicastrin endoplasmic reticulum membrane;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane;membrane-bounded organelle;nucleus;organelle;organelle membrane;organelle part binding;protein binding biopolymer metabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein maturation;protein metabolic process;protein processing 16 16 16 33.7 33.7 33.7 62.974 0 605570000 320720000 284850000 4983 IPI:IPI00470649.3;IPI:IPI00607732.1 Nicalin;Nicastrin-like protein NCLN Q969V3-1;Q969V3;Q969V3-2 ENST00000246117 2 NaN 2.5315 NaN NaN 1.5298 NaN FAD_binding_6;NAD_binding_1 cytoplasm;integral to membrane;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part catalytic activity;cytochrome-b5 reductase activity;electron carrier activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor alcohol metabolic process;biosynthetic process;cellular process;lipid biosynthetic process;lipid metabolic process;metabolic process;steroid biosynthetic process;steroid metabolic process;sterol biosynthetic process;sterol metabolic process Aminosugars metabolism 6 6 6 27.5 27.5 27.5 34.094 1.5621E-18 1379800 770460 609310 4984 IPI:IPI00470674.5 NADH-cytochrome b5 reductase 1;NAD(P)H:quinone oxidoreductase type 3 polypeptide A2;Humb5R2 CYB5R1;NQO3A2;UNQ3049/PRO9865 Q9UHQ9 ENST00000367249 K00326 1 0.58028 1.0541 0.60276 0.73678 0.7192 0.73815 DUF2465 4 4 4 17.8 17.8 17.8 37.329 1.3E-25 28160000 13018000 15142000 4985 IPI:IPI00470776.4;IPI:IPI00413170.8 Protein FAM98C FAM98C Q17RN3-1;Q17RN3;Q17RN3-2 ENST00000252530;ENST00000343358 2 0.85628 1.9937 0.91279 1.2011 1.1589 1.2502 Taxilin cell part;cytoplasm;extracellular region;intracellular part binding;cytokine activity;growth factor receptor binding;high molecular weight B cell growth factor receptor binding;protein binding;receptor binding cell proliferation;cellular process;establishment of localization;establishment of localization in cell;exocytosis;secretion;secretion by cell;transport;vesicle-mediated transport 15 15 15 21.4 21.4 21.4 61.89 2.7442E-88 374030000 193000000 181030000 4986 IPI:IPI00470779.2 Alpha-taxilin TXLNA;TXLN P40222 ENST00000373609;ENST00000373610 1 0.91054 1.4804 0.85425 1.1349 1.0109 1.0457 BRCT;FHA adherens junction;cell junction;cell-substrate adherens junction;cell-substrate junction;cytoskeleton;focal adhesion;intracellular non-membrane-bounded organelle;intracellular organelle;non-membrane-bounded organelle;nucleoplasm;organelle;organelle part binding;protein binding cell cycle;cellular process;DNA metabolic process;DNA repair;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to DNA damage stimulus;response to stress 11 11 11 6.8 6.8 6.8 226.66 1.0218E-122 139170000 96154000 43014000 4987 IPI:IPI00552897.2;IPI:IPI00470805.2;IPI:IPI00895860.1;IPI:IPI00895842.1 Mediator of DNA damage checkpoint protein 1;Nuclear factor with BRCT domains 1 MDC1;KIAA0170;NFBD1 Q14676-1;Q14676;Q14676-2;Q14676-3;Q14676-4 ENST00000376405;ENST00000376406;ENST00000383387 4 0.94269 1.7417 1.3295 1.3416 1.0776 1.7839 RhoGAP cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity biological regulation;cell communication;cellular process;regulation of biological process;regulation of cellular process;signal transduction 5 5 5 15.3 15.3 15.3 57.988 3.9981E-52 12345000 5610100 6735200 4988 IPI:IPI00470885.9;IPI:IPI00784933.2;IPI:IPI00514228.4;IPI:IPI00829662.1;IPI:IPI00793286.2;IPI:IPI00480149.3;IPI:IPI00783138.2 Rho GTPase-activating protein 19;Rho-type GTPase-activating protein 19 ARHGAP19 Q14CB8-2;Q14CB8;Q14CB8-1;Q14CB8-3;Q14CB8-6;Q14CB8-7 ENST00000316676;ENST00000358308;ENST00000358531;ENST00000393817 7 0.7634 1.2176 0.73576 0.96974 0.83069 0.95601 CSD cell part;cytoplasm;intracellular part binding;DNA binding;nucleic acid binding;protein binding;RNA binding gonad development;male gonad development;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of transcription, DNA-dependent;reproductive developmental process 30 30 30 38.8 38.8 38.8 88.884 0 1928100000 1034600000 893530000 4989 IPI:IPI00470891.2;IPI:IPI00873244.1 Cold shock domain-containing protein E1;UNR protein;N-ras upstream gene protein CSDE1;D1S155E;KIAA0885;NRU;UNR O75534-1;O75534;O75534-2 ENST00000339438;ENST00000358528;ENST00000369533 2 NaN 2.5443 NaN NaN 1.5998 NaN GRIP;Ran_BP1;TPR_2 binding establishment of localization;establishment of localization in cell;intracellular transport;transport 14 2 2 6.9 1.1 1.1 197.33 4.8851E-67 656000 317460 338540 4991 IPI:IPI00915967.2;IPI:IPI00470913.4;IPI:IPI00874205.1 RANBP2-like and GRIP domain-containing protein 1;Ran-binding protein 2-like 6;RANBP2-like and GRIP domain-containing protein 2 RGPD1;RANBP2L6;RGPD2;RANBP2L2 Q68DN6-2;Q68DN6;Q68DN6-1;P0C839 ENST00000339317;ENST00000398193;ENST00000409776;ENST00000327544;ENST00000398146;ENST00000409630 3 0.56755 1.4212 NaN 0.76018 0.92523 NaN PP2A_B_N;PP2A_B_subs_rcg cell part;cytoplasm;intracellular part;macromolecular complex;protein complex;protein phosphatase type 2A complex;protein serine/threonine phosphatase complex enzyme regulator activity;phosphatase regulator activity;protein phosphatase regulator activity;protein phosphatase type 2A regulator activity biological regulation;cell communication;cellular process;regulation of biological process;regulation of cellular process;signal transduction 5 1 1 15 3.8 3.8 52.042 4.5926E-63 9247900 5140800 4107100 4992 IPI:IPI00470920.1 Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform;PP2A, subunit B, B55-delta isoform;PP2A, subunit B, PR55-delta isoform;PP2A, subunit B, R2-delta isoform PPP2R2D;KIAA1541 Q66LE6 ENST00000314348 K04354 1 1.0884 1.6199 0.98928 1.3225 1.1334 1.3579 HLH cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;protein binding;transcription regulator activity cell proliferation;metabolic process;multicellular organismal development;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 4 4 4 17.8 17.8 17.8 34.27 3.6899E-22 100460000 45557000 54904000 4993 IPI:IPI00747776.2;IPI:IPI00471993.1;IPI:IPI00218206.1 T-cell acute lymphocytic leukemia protein 1;Stem cell protein;T-cell leukemia/lymphoma protein 5 TAL1;SCL;TCL5 P17542-1;P17542;P17542-2;P17542-3 ENST00000294339;ENST00000371883;ENST00000371884 K09068 3 NaN 1.7875 0.66939 NaN 1.1009 0.89652 ESSS cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial inner membrane;mitochondrial membrane;mitochondrial part;organelle inner membrane;organelle membrane;organelle part cellular metabolic process;cellular process;electron transport chain;establishment of localization;generation of precursor metabolites and energy;metabolic process;oxidation reduction;transport 2 2 2 20.9 20.9 20.9 18.364 4.1976E-15 11358000 6779200 4578400 4994 IPI:IPI00478450.1;IPI:IPI00472058.1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial;NADH-ubiquinone oxidoreductase ESSS subunit;Complex I-ESSS;Neuronal protein 17.3 NDUFB11;UNQ111/PRO1064 Q9NX14-2;Q9NX14;Q9NX14-1 ENST00000276062;ENST00000377811 2 0.84863 1.9295 NaN 1.1125 1.3356 NaN C1-set;MHC_I;MHC_I_C cell part;integral to membrane;intrinsic to membrane;macromolecular complex;membrane part;MHC class I protein complex;MHC protein complex;plasma membrane part;protein complex antigen processing and presentation;antigen processing and presentation of peptide antigen;antigen processing and presentation of peptide antigen via MHC class I;immune response;immune system process;interspecies interaction between organisms Allograft rejection;Antigen processing and presentation;Autoimmune thyroid disease;Cell adhesion molecules (CAMs);Graft-versus-host disease;Natural killer cell mediated cytotoxicity;Type I diabetes mellitus 5 3 1 17.8 11.2 4.1 40.932 2.1778E-126 12464000 6391700 6072000 4995 IPI:IPI00472162.1;IPI:IPI00744964.3;IPI:IPI00642409.2 HLA class I histocompatibility antigen, Cw-18 alpha chain;MHC class I antigen Cw*18;HLA class I histocompatibility antigen, Cw-6 alpha chain;MHC class I antigen Cw*6;HLA class I histocompatibility antigen, Cw-7 alpha chain;MHC class I antigen Cw*7 HLA-C;HLAC Q29865;Q29963;P10321 ENST00000400388;ENST00000400395;ENST00000376237;ENST00000396254 K06751 3 0.63189 1.3968 0.56647 0.79417 0.98889 0.71402 WH2 actin cytoskeleton;cell part;cell projection;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;lamellipodium;non-membrane-bounded organelle;organelle actin binding;binding;cytoskeletal protein binding;protein binding cell communication;cell surface receptor linked signal transduction;cytoskeleton organization;G-protein coupled receptor protein signaling pathway;organelle organization;signal transduction Adherens junction;Regulation of actin cytoskeleton 4 4 4 11.2 11.2 11.2 54.283 5.5768E-46 78577000 45115000 33462000 4996 IPI:IPI00472164.2;IPI:IPI00002647.2 Wiskott-Aldrich syndrome protein family member 2;Protein WAVE-2;Verprolin homology domain-containing protein 2;Wiskott-Aldrich syndrome protein family member 4 WASF2;WAVE2;WASF4;SCAR2 Q9Y6W5;Q8IV90 ENST00000374019;ENST00000338709 K05748 2 0.78595 1.5642 0.81009 0.99414 1.1006 0.96379 Kua-UEV1_localn;UQ_con cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;protein complex;ubiquitin conjugating enzyme complex acid-amino acid ligase activity;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;protein binding;small conjugating protein ligase activity;transcription activator activity;transcription regulator activity catabolic process;macromolecule catabolic process;metabolic process;protein modification process;protein polyubiquitination;proteolysis;regulation of biosynthetic process;regulation of DNA repair;regulation of transcription, DNA-dependent 8 4 4 53.1 29.3 29.3 16.495 2.1344E-59 338590000 183820000 154760000 4997 IPI:IPI00472498.3;IPI:IPI00019599.1;IPI:IPI00030962.7;IPI:IPI00447356.1;IPI:IPI00007847.1 Ubiquitin-conjugating enzyme E2 variant 1;CROC-1;TRAF6-regulated IKK activator 1 beta Uev1A UBE2V1;CROC1;UBE2V;UEV1;P/OKcl.19 Q13404-4;Q13404;Q13404-1;Q13404-7;Q13404-2;Q13404-6 ENST00000340309;ENST00000341698;ENST00000371658;ENST00000371674;ENST00000371677;ENST00000396059 K10704 5 1.0379 1.7129 1.0861 1.3994 1.1308 1.3698 dsrm cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;ribonucleoprotein complex;RNAi effector complex;RNA-induced silencing complex binding;double-stranded RNA binding;identical protein binding;nucleic acid binding;protein binding;protein dimerization activity;protein homodimerization activity;RNA binding;siRNA binding nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;regulation of translation;RNA processing 7 7 7 22.4 22.4 22.4 39.039 1.4092E-101 54183000 26248000 27934000 4998 IPI:IPI00847568.1;IPI:IPI00472583.2 RISC-loading complex subunit TARBP2;TAR RNA-binding protein 2;Trans-activation-responsive RNA-binding protein TARBP2;TRBP Q15633-1;Q15633;Q15633-2 ENST00000266987 2 1.2592 2.2964 1.0555 1.7035 1.4495 1.4445 cell part;integral to membrane;intrinsic to membrane;membrane part molecular transducer activity;signal transducer activity positive regulation of cell communication;positive regulation of protein kinase cascade;positive regulation of signal transduction;regulation of cell communication;regulation of protein kinase cascade;regulation of signal transduction 3 3 3 7.9 7.9 7.9 52.916 1.3249E-17 21061000 11506000 9554900 4999 IPI:IPI00472858.9;IPI:IPI00654550.2;IPI:IPI00786874.1 Protein GPR89;Putative MAPK-activating protein PM01;Putative NF-kappa-B-activating protein 90;Putative protein GPR89C GPR89A;GPR89;SH120;CGI-13;HSPC201;UNQ192/PRO218;GPR89B;GPR89C Q9Y302-1;Q9Y302;Q9Y302-2;A6NKF9 ENST00000313835;ENST00000314163;ENST00000356118 3 0.86571 1.579 0.90382 1.0732 1.1241 1.0667 SPC25 cell fraction;insoluble fraction;integral to membrane;intracellular part;intrinsic to membrane;macromolecular complex;membrane fraction;membrane part;microsome;organelle part;protein complex;signal peptidase complex;vesicular fraction catalytic activity;hydrolase activity;peptidase activity biopolymer metabolic process;cellular biopolymer metabolic process;cellular process;macromolecule metabolic process;metabolic process;peptide metabolic process;protein metabolic process;protein processing;signal peptide processing 6 6 6 27.4 27.4 27.4 25.003 2.4862E-18 334480000 170250000 164230000 5000 IPI:IPI00472939.3 Signal peptidase complex subunit 2;Microsomal signal peptidase 25 kDa subunit SPCS2;KIAA0102;SPC25 Q15005 ENST00000263672 1 NaN NaN 0.96662 NaN NaN 1.1785 Globin cell part;cytoplasmic part;cytosolic part;hemoglobin complex;intracellular part;macromolecular complex;protein complex binding;cation binding;heme binding;ion binding;iron ion binding;metal ion binding;oxygen binding;oxygen transporter activity;substrate-specific transporter activity;tetrapyrrole binding;transition metal ion binding;transporter activity establishment of localization;gas transport;oxygen transport;transport 8 1 1 48.3 8.8 8.8 16.055 1.79E-79 950640 586460 364180 5002 IPI:IPI00473011.3 Hemoglobin subunit delta;Hemoglobin delta chain;Delta-globin HBD P02042 ENST00000380299 1 1.0638 2.034 1.0747 1.4301 1.2806 1.4251 Cofilin_ADF actin binding;binding;cytoskeletal protein binding;protein binding actin cytoskeleton organization;actin filament organization;actin filament-based process;actin polymerization or depolymerization;cellular component organization;cellular process;cytoskeleton organization;organelle organization 12 11 11 69.7 63 63 18.506 8.8838E-193 1341600000 668420000 673170000 5003 IPI:IPI00473014.5 Destrin;Actin-depolymerizing factor DSTN;ACTDP;DSN P60981 ENST00000246069 K10363 1 0.84481 1.5868 0.86758 1.1192 1.0176 1.1546 CBS binding;cAMP-dependent protein kinase activity;cAMP-dependent protein kinase regulator activity;catalytic activity;cyclic nucleotide-dependent protein kinase activity;protein binding;protein kinase activity;protein serine/threonine kinase activity fatty acid biosynthetic process;fatty acid metabolic process;lipid metabolic process;organic acid metabolic process;protein amino acid phosphorylation;protein modification process;regulation of carbohydrate metabolic process;regulation of glycolysis Adipocytokine signaling pathway;Insulin signaling pathway 13 13 11 43.8 43.8 38.8 38.532 1.571E-290 331340000 174380000 156960000 5004 IPI:IPI00473047.2;IPI:IPI00219377.5 5'-AMP-activated protein kinase subunit gamma-1 PRKAG1 P54619 ENST00000316299;ENST00000395170 K07200 2 0.64613 0.95061 0.50539 0.81599 0.66682 0.67715 Nup188 cell part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;organelle part;pore complex;protein complex binding;protein binding cellular process;establishment of protein localization;intracellular protein transport;intracellular transport;mRNA transport;nucleic acid transport;nucleobase, nucleoside, nucleotide and nucleic acid transport;protein transport;RNA transport;transport 21 21 21 13.4 13.4 13.4 196.04 6.6424E-159 399940000 186920000 213020000 5005 IPI:IPI00477040.1;IPI:IPI00385001.4 Nucleoporin NUP188 homolog NUP188;KIAA0169 Q5SRE5-1;Q5SRE5;Q5SRE5-2 ENST00000356693;ENST00000372577 2 0.93768 1.5667 0.8286 1.1849 1.0666 1.0974 DUF2359 cell part;integral to membrane;intrinsic to membrane;membrane part binding;protein binding 11 11 11 20.3 20.3 20.3 77.15 9.3647E-81 173220000 89307000 83911000 5006 IPI:IPI00477118.3 Transmembrane protein 214 TMEM214;PP446 Q6NUQ4 ENST00000238788 1 NaN 1.5855 0.74135 NaN 1.0109 1.0336 NAGidase cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle beta-N-acetylhexosaminidase activity;catalytic activity;histone acetyltransferase activity;hyalurononglucosaminidase activity;hydrolase activity, hydrolyzing O-glycosyl compounds;lysine N-acetyltransferase activity;N-acetyltransferase activity biopolymer catabolic process;biopolymer metabolic process;catabolic process;cellular process;glycoprotein catabolic process;glycoprotein metabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process 6 6 6 7.6 7.6 7.6 111.18 9.422E-27 15789000 7948000 7841200 5007 IPI:IPI00477231.3;IPI:IPI00941608.1;IPI:IPI00465449.3 Bifunctional protein NCOAT;Nuclear cytoplasmic O-GlcNAcase and acetyltransferase;Meningioma-expressed antigen 5;Beta-hexosaminidase;N-acetyl-beta-glucosaminidase;Beta-N-acetylhexosaminidase;Hexosaminidase C;N-acetyl-beta-D-glucosaminidase;O-GlcNAcase;Histone acetyltransferase MGEA5;HEXC;KIAA0679;MEA5 O60502-1;O60502;O60502-2 ENST00000361464 3 NaN 2.3009 NaN NaN 1.4464 NaN RhoGAP cell part;intracellular enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity biological regulation;cell communication;cellular process;regulation of biological process;regulation of cellular process;signal transduction 3 3 3 4.5 4.5 4.5 113.86 2.801E-75 3665100 1164800 2500300 5008 IPI:IPI00477330.3;IPI:IPI00654746.1 Rho GTPase-activating protein 11A;Rho-type GTPase-activating protein 11A ARHGAP11A;KIAA0013 Q6P4F7 ENST00000361627 2 0.59891 1.3354 0.67294 0.80084 0.86174 0.89474 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle binding;cytoskeletal protein binding;kinesin binding;protein binding anatomical structure development;cell differentiation;cellular developmental process;cellular process;developmental process;intracellular transport;mitochondrial transport;nervous system development;system development;transport 3 3 3 5.3 5.3 5.3 71.813 9.6595E-08 37188000 20737000 16451000 5009 IPI:IPI00477355.3 KIF1-binding protein KIAA1279;KBP Q96EK5 ENST00000361983 1 0.8025 1.4601 0.76878 1.0632 0.98882 0.9807 TPR_1 cell part;intracellular organelle part;intracellular part;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part binding 16 16 16 15.7 15.7 15.7 133.5 1.4098E-108 291690000 151070000 140620000 5010 IPI:IPI00477468.1 RNA polymerase-associated protein CTR9 homolog;SH2 domain-binding protein 1 CTR9;KIAA0155;SH2BP1 Q6PD62 ENST00000361367 1 0.64257 1.5374 0.84487 0.89176 0.98986 1.0497 Ank cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;protein binding 7 6 6 9 7.3 7.3 116.54 1.4652E-156 14363000 7620700 6742400 5011 IPI:IPI00477505.3;IPI:IPI00514769.3 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A;Ankyrin repeat domain-containing protein 28;Phosphatase interactor targeting protein hnRNP K ANKRD28;KIAA0379 O15084-1;O15084;O15084-2 ENST00000383776;ENST00000383777;ENST00000399451 2 0.56639 1.0968 0.60322 0.71589 0.73353 0.7659 DUF2049 6 6 6 15.5 15.5 15.5 56.196 1.7216E-54 95476000 32945000 62531000 5012 IPI:IPI00477526.2 UPF0550 protein C7orf28 C7orf28A;CGI-43;C7orf28B O95766 ENST00000316731;ENST00000325974 1 0.59291 1.5404 NaN 0.8497 0.95796 NaN XPG_I;XPG_N cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part bubble DNA binding;catalytic activity;DNA binding;DNA secondary structure binding;double-stranded DNA binding;endodeoxyribonuclease activity;endonuclease activity;nuclease activity;nucleic acid binding;single-stranded DNA binding DNA catabolic process, endonucleolytic;DNA metabolic process;DNA repair;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleotide-excision repair, DNA damage removal;system process;transcription-coupled nucleotide-excision repair Nucleotide excision repair 3 3 3 3.5 3.5 3.5 133.11 1.6718E-22 8059900 4635400 3424500 5013 IPI:IPI00477535.6;IPI:IPI00640241.1 DNA repair protein complementing XP-G cells;Xeroderma pigmentosum group G-complementing protein;DNA excision repair protein ERCC-5 ERCC5;ERCM2;XPG;XPGC P28715-1;P28715 ENST00000355739 K10846 2 0.85744 1.539 0.81965 1.1451 1.0057 1.0914 CH;Filamin actin cytoskeleton;cell cortex;cytoskeleton;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intrinsic to membrane;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle;Z disc actin binding;binding;cytoskeletal protein binding;protein binding actin filament-based process;cell communication;cellular component organization;cellular process;cytoskeletal anchoring at plasma membrane;cytoskeleton organization;muscle organ development;organelle organization;signal transduction Focal adhesion;MAPK signaling pathway 99 99 95 49.1 49.1 47.6 276.94 0 5051800000 2611600000 2440200000 5014 IPI:IPI00477536.3;IPI:IPI00289334.1;IPI:IPI00953109.1;IPI:IPI00382697.1;IPI:IPI00940093.1;IPI:IPI00382698.1;IPI:IPI00382699.1;IPI:IPI00178352.6;IPI:IPI00413958.5 Filamin-B;Beta-filamin;Actin-binding-like protein;Thyroid autoantigen;Truncated actin-binding protein;ABP-280 homolog;ABP-278;Filamin 3;Filamin homolog 1 FLNB;FLN1L;FLN3;TABP;TAP O75369-2;O75369;O75369-1;O75369-6;O75369-3;O75369-7;O75369-4;O75369-5 ENST00000295956;ENST00000348383;ENST00000357272;ENST00000358537 K04437 9 0.56696 1.0664 NaN 0.83786 0.64652 NaN DUF1740 binding;protein binding 4 4 4 5.3 5.3 5.3 132.42 2.9283E-76 2871200 1559900 1311300 5015 IPI:IPI00477539.3 UPF0614 protein C14orf102 C14orf102 Q9H7Z3 ENST00000354366 1 0.62243 1.4152 0.56641 0.88531 0.90824 0.68284 Prefoldin cytoplasmic part;cytosolic part;DNA-directed RNA polymerase complex;DNA-directed RNA polymerase II, core complex;intracellular part;macromolecular complex;nuclear part;organelle part;prefoldin complex;protein complex;RNA polymerase complex binding;protein binding;transcription cofactor activity;transcription corepressor activity;transcription factor binding;transcription regulator activity;transcription repressor activity;unfolded protein binding cellular process;metabolic process;protein folding;regulation of biosynthetic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;response to biotic stimulus;response to virus 3 3 3 9 9 9 59.832 1.4904E-38 17847000 9931200 7915400 5016 IPI:IPI00477619.2;IPI:IPI00743872.4 Unconventional prefoldin RPB5 interactor;RNA polymerase II subunit 5-mediating protein;Protein NNX3 RMP;C19orf2;NNX3;URI O94763-1;O94763;O94763-2 ENST00000312051;ENST00000392271 2 0.69838 1.3672 0.77315 0.9221 0.90756 0.99688 2 2 2 1 1 1 209.52 0.0013425 94003000 53317000 40686000 5017 IPI:IPI00792611.3;IPI:IPI00477620.3;IPI:IPI00829780.1 Uncharacterized protein KIAA0802 KIAA0802 Q9Y4B5-1;Q9Y4B5;Q9Y4B5-3;Q9Y4B5-2 ENST00000306285;ENST00000306329;ENST00000359865;ENST00000400050 3 0.76455 1.3528 0.73335 0.99349 0.93678 0.96992 TFIIF_beta cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;organelle;organelle part;protein complex;transcription factor complex;transcription factor TFIIF complex ATP binding;ATP-dependent helicase activity;binding;catalytic activity;DNA binding;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;RNA polymerase II transcription factor activity nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile Basal transcription factors 10 10 10 55.4 55.4 55.4 28.38 8.1616E-29 255480000 133490000 121990000 5018 IPI:IPI00477686.2 General transcription factor IIF subunit 2;Transcription initiation factor IIF subunit beta;ATP-dependent helicase GTF2F2;Transcription initiation factor RAP30 GTF2F2;RAP30 P13984 ENST00000358995 K03139 1 0.90985 1.6485 0.88641 1.1442 1.0624 1.2644 ACOX;Acyl-CoA_dh_M acyl-CoA dehydrogenase activity;acyl-CoA oxidase activity;binding;catalytic activity;electron carrier activity;nucleoside binding;nucleotide binding;oxidoreductase activity;protein binding;purine nucleoside binding fatty acid beta-oxidation;fatty acid metabolic process;generation of precursor metabolites and energy;icosanoid metabolic process;lipid metabolic process;organic acid metabolic process;prostaglandin metabolic process;prostanoid metabolic process alpha-Linolenic acid metabolism;Biosynthesis of unsaturated fatty acids;Fatty acid metabolism;PPAR signaling pathway 16 16 16 34.5 34.5 34.5 74.667 8.3765E-245 339440000 181730000 157710000 5019 IPI:IPI00477729.2;IPI:IPI00296907.4 Peroxisomal acyl-coenzyme A oxidase 1;Palmitoyl-CoA oxidase;Straight-chain acyl-CoA oxidase ACOX1;ACOX Q15067-2;Q15067;Q15067-1 ENST00000293217;ENST00000301608 K00232 2 0.54163 0.7998 0.55708 0.67314 0.57018 0.67591 integral to membrane;integrator complex;intracellular organelle part;intracellular part;intrinsic to membrane;macromolecular complex;membrane;membrane part;nuclear membrane;nuclear part;nucleoplasm part;organelle membrane;organelle part;protein complex binding;protein binding cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;snRNA metabolic process;snRNA processing 4 4 4 4.2 4.2 4.2 134.34 1.6252E-44 22433000 12639000 9794700 5020 IPI:IPI00477759.1 Integrator complex subunit 2 INTS2;KIAA1287 Q9H0H0 ENST00000251334 1 0.90957 2.1107 0.64242 1.1467 1.4405 0.83817 ELM2;Myb_DNA-binding cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;molecular transducer activity;nucleic acid binding;signal transducer activity biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 4 4 4 8.8 8.8 8.8 63.425 3.0101E-32 13337000 7303200 6034200 5021 IPI:IPI00655783.4;IPI:IPI00477825.3;IPI:IPI00655630.1;IPI:IPI00478280.3;IPI:IPI00479032.2;IPI:IPI00640919.1;IPI:IPI00656089.1;IPI:IPI00655845.1;IPI:IPI00646985.1;IPI:IPI00656079.1 Mesoderm induction early response protein 1 MIER1;KIAA1610 Q8N108-2;Q8N108;Q8N108-1;Q8N108-8;Q8N108-10;Q8N108-3;Q8N108-5;Q8N108-7;Q8N108-4;Q8N108-6 ENST00000262348;ENST00000354777;ENST00000355356;ENST00000355977;ENST00000371017;ENST00000371018;ENST00000401040 10 0.92873 1.8795 0.97666 1.244 1.2093 1.2428 Peptidase_M1 cytosol;endoplasmic reticulum lumen;endoplasmic reticulum membrane;extracellular region;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;membrane-enclosed lumen;organelle lumen;organelle membrane;organelle part aminopeptidase activity;binding;catalytic activity;cytokine receptor binding;interleukin-1 receptor binding;interleukin-1, Type II receptor binding;interleukin-6 receptor binding;peptidase activity;protein binding;receptor binding angiogenesis;antigen processing and presentation of endogenous peptide antigen;antigen processing and presentation of peptide antigen via MHC class I;immune system process;proteolysis;regulation of immune system process 25 25 25 30.1 30.1 30.1 107.23 2.2765E-233 577630000 247660000 329970000 5022 IPI:IPI00477831.2;IPI:IPI00165949.2 Endoplasmic reticulum aminopeptidase 1;Adipocyte-derived leucine aminopeptidase;ARTS-1;Aminopeptidase PILS;Puromycin-insensitive leucyl-specific aminopeptidase;Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator ERAP1;APPILS;ARTS1;KIAA0525;UNQ584/PRO1154 Q9NZ08-1;Q9NZ08;Q9NZ08-2 ENST00000296754 K09604 2 0.208 0.42645 0.13777 0.27885 0.2599 0.16754 zf-FCS cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding developmental process;multicellular organismal development;multicellular organismal process 7 7 6 4.1 4.1 3.5 172.79 7.0781E-12 15355000 9872200 5482700 5023 IPI:IPI00477949.1;IPI:IPI00642195.2;IPI:IPI00513965.4;IPI:IPI00856055.1 Zinc finger MYM-type protein 4;Zinc finger protein 262 ZMYM4;KIAA0425;ZNF262 Q5VZL5-1;Q5VZL5;Q5VZL5-4;Q5VZL5-2;Q5VZL5-3 ENST00000314607;ENST00000373297 4 0.72643 1.4443 0.68073 0.89238 0.98275 0.86112 UDPGP catalytic activity;nucleotidyltransferase activity;transferase activity;transferase activity, transferring phosphorus-containing groups metabolic process 5 4 4 11.2 8.7 8.7 57.03 6.0606E-75 4457900000 2289500000 2168300000 5024 IPI:IPI00477962.3;IPI:IPI00798010.1 UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 UAP1L1 Q3KQV9-1;Q3KQV9 ENST00000409858 2 0.51842 0.94445 0.50474 0.66965 0.646 0.65173 Utp13;WD40 intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;preribosome;ribonucleoprotein complex;small-subunit processome molecular transducer activity;receptor signaling protein activity;signal transducer activity cell communication;cell surface receptor linked signal transduction;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA processing;rRNA processing;signal transduction 23 23 23 42.1 42.1 42.1 89.034 0 545510000 316720000 228780000 5025 IPI:IPI00477971.4 Transducin beta-like protein 3;WD repeat-containing protein SAZD TBL3;SAZD Q12788 ENST00000332704 1 0.51363 0.98812 NaN 0.69119 0.66042 NaN 2 2 2 3.8 3.8 3.8 71.078 7.6992E-07 550980 309320 241660 5026 IPI:IPI00478068.2 Glutathione S-transferase C-terminal domain-containing protein GSTCD Q8NEC7 ENST00000360505;ENST00000394728 1 NaN 1.2647 NaN NaN 0.90663 NaN KH_1;zf-C3HC4 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;nucleic acid binding;protein binding;RNA binding;transition metal ion binding;zinc ion binding 2 2 2 2.8 2.8 2.8 64.882 0.001776 29954000 15342000 14611000 5027 IPI:IPI00478085.3;IPI:IPI00783891.3 RNA-binding protein MEX3D;RING finger and KH domain-containing protein 1;RING finger protein 193;TINO MEX3D;KIAA2031;RKHD1;RNF193 Q86XN8-1;Q86XN8;Q86XN8-2 ENST00000402693;ENST00000403287 2 NaN 1.3025 0.75419 NaN 0.88946 0.93626 WD40 cell part;histone methyltransferase complex;intracellular organelle part;intracellular part;macromolecular complex;methyltransferase complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;protein binding 2 2 2 3.5 3.5 3.5 63.303 1.1787E-08 13429000 4564800 8864700 5028 IPI:IPI00478230.2;IPI:IPI00645975.1 Retinoblastoma-binding protein 5;Retinoblastoma-binding protein RBQ-3 RBBP5;RBQ3 Q15291-1;Q15291;Q15291-2 ENST00000264515 2 0.89044 1.4612 0.8591 1.1527 0.96333 1.1245 Ras cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane;non-membrane-bounded organelle;organelle;plasma membrane binding;catalytic activity;cytoskeletal protein binding;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;magnesium ion binding;nucleotide binding;protein binding;pyrophosphatase activity cell communication;intracellular signaling cascade;positive regulation of signal transduction;Ras protein signal transduction;regulation of signal transduction;Rho protein signal transduction;signal transduction;small GTPase mediated signal transduction Adherens junction;Axon guidance;Chemokine signaling pathway;Colorectal cancer;Focal adhesion;Leukocyte transendothelial migration;Pathways in cancer;Regulation of actin cytoskeleton;T cell receptor signaling pathway;TGF-beta signaling pathway;Tight junction;Vascular smooth muscle contraction;Wnt signaling pathway 10 10 3 65.8 65.8 20.2 21.768 1.588E-170 1620700000 821570000 799110000 5029 IPI:IPI00478231.2 Transforming protein RhoA;H12 RHOA;ARH12;ARHA;RHO12 P61586 ENST00000265538 K04513 1 0.83241 1.5625 0.74621 1.1186 1.0683 0.9889 ATP-synt intracellular part;macromolecular complex;membrane part;mitochondrial matrix;mitochondrial proton-transporting ATP synthase complex, catalytic core F(1);organelle part;protein complex;proton-transporting two-sector ATPase complex, catalytic domain catalytic activity;cation transmembrane transporter activity;hydrogen ion transmembrane transporter activity;ion transmembrane transporter activity;monovalent inorganic cation transmembrane transporter activity;transporter activity ATP biosynthetic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;transport Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 11 11 11 44.6 44.6 44.6 32.996 7.1479E-141 1752300000 947210000 805110000 5030 IPI:IPI00478410.2;IPI:IPI00395769.2 ATP synthase subunit gamma, mitochondrial;F-ATPase gamma subunit ATP5C1;ATP5C;ATP5CL1 P36542-1;P36542;P36542-2 ENST00000335698;ENST00000356708;ENST00000397106 K02136 2 0.2735 NaN NaN 0.33864 NaN NaN SPRY;zf-B_box cell part;intracellular binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding 2 2 2 5.4 5.4 5.4 49.772 4.2156E-14 228180 155520 72653 5031 IPI:IPI00478468.2 Tripartite motif-containing protein 14 TRIM14;KIAA0129 Q14142-1;Q14142 ENST00000311688;ENST00000341469;ENST00000342043;ENST00000375098 K12004 1 0.48117 0.73532 0.3719 0.64308 0.48657 0.49789 catalytic activity 5 5 5 8.7 8.7 8.7 70.195 6.6051E-90 27761000 16145000 11615000 5032 IPI:IPI00478616.1 Protein FAM111A FAM111A;KIAA1895 Q96PZ2 ENST00000361723 1 0.75389 1.5226 0.81168 1.0101 1.0152 1.0094 RRM_1 cell part;cytoplasm;intracellular part binding;mRNA binding;nucleic acid binding;RNA binding cellular process;metabolic process;mRNA metabolic process;mRNA polyadenylation;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing 15 15 15 33.5 33.5 33.5 53.126 4.6725E-148 503890000 259030000 244860000 5033 IPI:IPI00478657.4 G-rich sequence factor 1 GRSF1 Q12849 ENST00000254799 1 0.7408 1.3348 0.70149 0.99519 0.8923 0.91385 Peptidase_M16;Peptidase_M16_C cell part;cell surface;cytoplasmic part;cytosol;intracellular part binding;catalytic activity;cation binding;endopeptidase activity;growth factor binding;hormone binding;hydrolase activity;ion binding;metalloendopeptidase activity;metallopeptidase activity;peptidase activity;protein binding;zinc ion binding catabolic process;cell motion;cell proliferation;macromolecule catabolic process;metabolic process;neuromuscular junction development;positive regulation of metabolic process;proteolysis;regulation of catabolic process 23 23 23 20 20 20 139.28 6.2753E-266 751630000 406830000 344800000 5034 IPI:IPI00889668.1;IPI:IPI00478723.3 Nardilysin;N-arginine dibasic convertase NRD1 O43847-2;O43847;O43847-1 ENST00000352171;ENST00000354831 K01411 2 0.58174 0.89304 0.61326 0.76516 0.60538 0.8089 NAD_binding_4;Sterile integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intrinsic to membrane;membrane;membrane-bounded organelle;microbody;microbody membrane;organelle;organelle membrane;organelle part;peroxisomal membrane binding;catalytic activity;oxidoreductase activity;protein binding biosynthetic process;lipid biosynthetic process;lipid metabolic process;metabolic process;oxidation reduction;primary metabolic process 6 6 6 15.7 15.7 15.7 59.356 3.0859E-78 101500000 57831000 43664000 5035 IPI:IPI00478838.3 Fatty acyl-CoA reductase 1;Male sterility domain-containing protein 2 FAR1;MLSTD2;UNQ2423/PRO4981 Q8WVX9 ENST00000354817 1 0.65722 1.6291 0.67212 0.96321 0.94714 0.95599 Ribosomal_S19 cell part;cytoplasmic part;cytosolic part;cytosolic small ribosomal subunit;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit binding;DNA binding;nucleic acid binding;protein binding;structural constituent of ribosome;structural molecule activity nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;ribosomal small subunit export from nucleus;ribosome export from nucleus;RNA processing;rRNA processing;translational elongation;transport Ribosome 4 4 4 37.2 37.2 37.2 17.04 7.7361E-208 2159000000 1154500000 1004500000 5036 IPI:IPI00479058.2 40S ribosomal protein S15;RIG protein RPS15;RIG P62841 ENST00000233609 K02958 1 NaN 1.6873 NaN NaN 1.0358 NaN FCH;RhoGAP;SH3_1 cell part;intracellular enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity biological regulation;cell communication;cellular process;regulation of biological process;regulation of cellular process;signal transduction Axon guidance 2 2 2 2.1 2.1 2.1 120.88 5.0051E-20 2648700 1577600 1071100 5037 IPI:IPI00479125.3;IPI:IPI00376259.1;IPI:IPI00414827.1 SLIT-ROBO Rho GTPase-activating protein 2;Formin-binding protein 2;SLIT-ROBO Rho GTPase-activating protein 1;Rho GTPase-activating protein 13 SRGAP2;FNBP2;KIAA0456;SRGAP1;ARHGAP13;KIAA1304 O75044;Q7Z6B7-1;Q7Z6B7;Q7Z6B7-2 ENST00000295713;ENST00000355086;ENST00000357825 K07526 3 1.0783 1.7877 1.1139 1.3919 1.222 1.3453 WD40 binding;protein binding cellular component organization;cellular process;ER to Golgi vesicle-mediated transport;establishment of protein localization;intracellular protein transport;membrane organization;protein transport;transport;vesicle-mediated transport 9 9 9 41.6 41.6 41.6 35.54 4.1346E-212 713890000 302320000 411570000 5038 IPI:IPI00479141.2 Protein SEC13 homolog;SEC13-related protein;SEC13-like protein 1 SEC13;D3S1231E;SEC13L1;SEC13R P55735 ENST00000337354;ENST00000343726;ENST00000350697;ENST00000383801 1 0.61561 1.156 0.44279 0.77288 0.80968 0.58228 PACT_coil_coil centrosome;cytoplasmic part;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;microtubule organizing center;non-membrane-bounded organelle;organelle;organelle part binding;calmodulin binding;protein binding anatomical structure formation;cell projection assembly;cell projection organization;cellular component assembly;cellular component organization;cellular process;cilium assembly 7 7 7 2.6 2.6 2.6 378.08 5.7708E-21 12531000 6836000 5694600 5039 IPI:IPI00479143.2 Pericentrin;Pericentrin-B;Kendrin PCNT;KIAA0402;PCNT2 O95613 ENST00000359568 1 0.75887 1.5139 0.72656 1.014 0.97259 0.97289 PK;PK_C cell part;cytoplasmic part;cytosol;intracellular part ATP binding;binding;catalytic activity;kinase activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyruvate kinase activity;transferase activity alcohol metabolic process;carbohydrate metabolic process;catabolic process;cellular process;generation of precursor metabolites and energy;glucose catabolic process;glucose metabolic process;glycolysis;metabolic process;monosaccharide metabolic process Carbon fixation in photosynthetic organisms;Glycolysis / Gluconeogenesis;Purine metabolism;Pyruvate metabolism;Type II diabetes mellitus 46 46 5 74 74 9.4 57.936 0 48510000000 26441000000 22069000000 5040 IPI:IPI00479186.7 Pyruvate kinase isozymes M1/M2;Pyruvate kinase muscle isozyme;Pyruvate kinase 2/3;Cytosolic thyroid hormone-binding protein;THBP1;p58;M2-PK;Tumor M2-PK PKM2;PK2;PK3;PKM P14618-1;P14618 ENST00000319622;ENST00000335181;ENST00000389093 K00873 1 0.78364 1.5286 0.77145 1.0319 1.001 1.0079 SAP;SPRY cell part;cell surface;heterogeneous nuclear ribonucleoprotein complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex adenyl nucleotide binding;ATP binding;binding;DNA binding;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 35 35 34 39.8 39.8 39 90.583 0 15479000000 8107400000 7371600000 5041 IPI:IPI00883857.2;IPI:IPI00479217.1 Heterogeneous nuclear ribonucleoprotein U;Scaffold attachment factor A;p120;pp120 HNRNPU;HNRPU;SAFA;U21.1 Q00839-1;Q00839;Q00839-2 ENST00000283179;ENST00000366525 2 0.65033 1.2998 0.65049 0.88514 0.85737 0.853 MA3;MIF4G;W2 cell part;cytoplasmic part;cytosol;eukaryotic translation initiation factor 4F complex;intracellular part;macromolecular complex;protein complex binding;nucleic acid binding;protein binding;RNA binding;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of translation;regulation of translational initiation;translation 41 41 35 32.8 32.8 29.2 175.62 0 3839700000 2095800000 1743900000 5042 IPI:IPI00479262.4;IPI:IPI00927510.1;IPI:IPI00927765.1;IPI:IPI00552639.2;IPI:IPI00759560.2 Eukaryotic translation initiation factor 4 gamma 1;p220 EIF4G1;EIF4F;EIF4G;EIF4GI Q04637-3;Q04637;Q04637-5;Q04637-6;Q04637-1;Q04637-4 ENST00000319274;ENST00000346169;ENST00000350481;ENST00000352767;ENST00000382330;ENST00000382362;ENST00000392534;ENST00000392537 5 0.87033 1.574 0.89163 1.1335 1.1173 1.1175 Proteasome cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;proteasome core complex;protein complex binding;catalytic activity;endopeptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides;protein binding;threonine-type endopeptidase activity;threonine-type peptidase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Proteasome 9 9 9 42.2 42.2 42.2 28.48 7.415E-160 2145200000 1113900000 1031300000 5043 IPI:IPI00479306.1 Proteasome subunit beta type-5;Proteasome epsilon chain;Macropain epsilon chain;Multicatalytic endopeptidase complex epsilon chain;Proteasome subunit X;Proteasome chain 6;Proteasome subunit MB1 PSMB5;LMPX P28074 ENST00000361611 K02737 1 0.43868 1.658 NaN 0.61425 0.96677 NaN Methyltransf_11 catalytic activity;methyltransferase activity;transferase activity;transferase activity, transferring one-carbon groups metabolic process 4 4 4 8.6 8.6 8.6 78.767 2.9778E-54 76674000 45396000 31278000 5044 IPI:IPI00514340.1;IPI:IPI00479432.1;IPI:IPI00604631.1;IPI:IPI00409639.1;IPI:IPI00384061.2 Methyltransferase-like protein 13 METTL13;KIAA0859;CGI-01 Q8N6R0-5;Q8N6R0;Q8N6R0-3;Q8N6R0-4;Q8N6R0-1;Q8N6R0-2 ENST00000341850;ENST00000361735;ENST00000367737;ENST00000367738 5 NaN 1.5663 NaN NaN 0.98429 NaN I-set;PH;Pkinase;RhoGEF;SH3_1;Spectrin cell part;cytoplasm;intracellular part catalytic activity;guanyl-nucleotide exchange factor activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;small GTPase regulator activity cell communication;cell surface receptor linked signal transduction;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;signal transduction 2 2 2 0.8 0.8 0.8 346.9 4.866E-07 1082000 655010 427030 5045 IPI:IPI00657953.2;IPI:IPI00943836.1;IPI:IPI00479523.6;IPI:IPI00943984.1 Triple functional domain protein;PTPRF-interacting protein TRIO O75962-1;O75962;O75962-4;O75962-2;O75962-5 ENST00000344135;ENST00000344204 K08810 4 0.4988 1.1106 0.5996 0.67261 0.71815 0.77693 Jnk-SapK_ap_N acrosomal vesicle;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;integral to membrane;intracellular organelle;intrinsic to membrane;membrane-bounded organelle;membrane-bounded vesicle;organelle;secretory granule;vesicle binding;protein binding gamete generation;male gamete generation;positive regulation of biological process;positive regulation of cell migration;regulation of cell migration;regulation of localization;regulation of locomotion;reproductive process;spermatogenesis 10 10 10 8.6 8.6 8.6 146.2 7.0426E-173 93571000 50504000 43067000 5046 IPI:IPI00744648.1;IPI:IPI00479676.5;IPI:IPI00384432.4;IPI:IPI00879552.1;IPI:IPI00744288.1;IPI:IPI00748244.1;IPI:IPI00303397.5;IPI:IPI00219817.1;IPI:IPI00398504.5;IPI:IPI00748833.1 C-jun-amino-terminal kinase-interacting protein 4;JNK-associated leucine-zipper protein;Sperm-associated antigen 9;Mitogen-activated protein kinase 8-interacting protein 4;Human lung cancer oncogene 6 protein;Proliferation-inducing protein 6;Sperm-specific protein;Sperm surface protein;Protein highly expressed in testis;Sunday driver 1;Cancer/testis antigen 89 SPAG9;HSS;KIAA0516;MAPK8IP4;SYD1;HLC6 O60271-1;O60271;O60271-4;O60271-2;O60271-3;O60271-5;O60271-7 ENST00000357122;ENST00000357791;ENST00000357804;ENST00000376407 10 0.79539 1.5678 0.85634 1.0445 1.0412 1.118 PA28_alpha;PA28_beta cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;proteasome activator complex;protein complex proteasome activator activity;proteasome regulator activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Antigen processing and presentation;Proteasome 18 18 18 69.1 69.1 69.1 28.723 1.9536E-144 2592000000 1358800000 1233300000 5047 IPI:IPI00479722.2 Proteasome activator complex subunit 1;Proteasome activator 28 subunit alpha;Activator of multicatalytic protease subunit 1;11S regulator complex subunit alpha;Interferon gamma up-regulated I-5111 protein PSME1;IFI5111 Q06323 ENST00000206451;ENST00000382708 K06696 1 0.9557 1.821 0.79649 1.293 1.1528 0.9594 Pkinase cell part;coated pit;membrane part ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cellular biopolymer metabolic process;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process 16 16 14 22.5 22.5 20.3 93.577 2.0117E-155 106400000 56302000 50095000 5049 IPI:IPI00479760.7 AP2-associated protein kinase 1;Adaptor-associated kinase 1 AAK1;KIAA1048 Q2M2I8 ENST00000390657;ENST00000406297;ENST00000409085 K08853 1 0.7986 1.4659 0.79111 1.0021 0.98851 1.026 DUF1897;KH_1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;DNA binding;nucleic acid binding;protein binding;RNA binding;RNA splicing factor activity, transesterification mechanism biosynthetic process;metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;RNA processing;RNA splicing;transcription;transport 34 34 31 54.3 54.3 50.4 73.114 0 3231200000 1679700000 1551500000 5050 IPI:IPI00479786.5;IPI:IPI00855957.2 Far upstream element-binding protein 2;KH type-splicing regulatory protein;p75 KHSRP;FUBP2 Q92945-1;Q92945;Q92945-2 ENST00000201886;ENST00000398148 2 0.85618 1.6644 0.79711 1.1255 1.0914 1.0541 Aldedh cell part;cytoskeleton;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle aldehyde dehydrogenase (NAD) activity;catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on the aldehyde or oxo group of donors;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor biosynthetic process;cellular aldehyde metabolic process;cellular process;metabolic process;neurotransmitter biosynthetic process;neurotransmitter metabolic process;regulation of hormone levels;regulation of neurotransmitter levels 1,2-Dichloroethane degradation;3-Chloroacrylic acid degradation;Arginine and proline metabolism;Ascorbate and aldarate metabolism;beta-Alanine metabolism;Butanoate metabolism;Fatty acid metabolism;Glycerolipid metabolism;Glycolysis / Gluconeogenesis;Histidine metabolism;Limonene and pinene degradation;Lysine degradation;Propanoate metabolism;Pyruvate metabolism;Tryptophan metabolism;Valine, leucine and isoleucine degradation 19 19 19 34.6 34.6 34.6 56.291 3.1943E-254 1337800000 706230000 631530000 5051 IPI:IPI00479877.4 4-trimethylaminobutyraldehyde dehydrogenase;Aldehyde dehydrogenase family 9 member A1;Aldehyde dehydrogenase E3 isozyme;Gamma-aminobutyraldehyde dehydrogenase;R-aminobutyraldehyde dehydrogenase ALDH9A1;ALDH4;ALDH7;ALDH9 P49189 ENST00000271359;ENST00000354775 K00128;K00137;K00149 1 0.74271 1.495 0.76264 0.97387 1.0044 0.9607 NDUFB10 cytoplasmic part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;mitochondrial membrane part;mitochondrial part;mitochondrial respiratory chain complex I;NADH dehydrogenase complex;organelle part;protein complex binding;catalytic activity;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;protein binding cellular metabolic process;cellular process;electron transport chain;generation of precursor metabolites and energy;metabolic process;mitochondrial electron transport, NADH to ubiquinone;respiratory electron transport chain;transport Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 7 7 7 37.8 37.8 37.8 20.776 3.2023E-45 255350000 138610000 116740000 5052 IPI:IPI00479905.5 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10;NADH-ubiquinone oxidoreductase PDSW subunit;Complex I-PDSW NDUFB10 O96000 ENST00000268668 K03966 1 0.48722 2.0525 0.58033 0.63793 1.3053 0.75447 PX;WH2 cell part;cytoplasm;intracellular part;membrane;plasma membrane actin binding;ATP binding;binding;catalytic activity;cytoskeletal protein binding;kinase activity;lipid binding;nucleoside binding;nucleotide binding;phospholipid binding;protein binding;protein kinase activity;purine nucleoside binding cell communication;defense response;inflammatory response;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;response to external stimulus;response to stress 4 4 4 7.6 7.6 7.6 64.949 5.4626E-35 33878000 16742000 17135000 5053 IPI:IPI00479912.3;IPI:IPI00654715.2;IPI:IPI00655529.1;IPI:IPI00655607.3;IPI:IPI00556666.2;IPI:IPI00655666.1;IPI:IPI00656013.1 PX domain-containing protein kinase-like protein;Modulator of Na,K-ATPase PXK Q7Z7A4-1;Q7Z7A4;Q7Z7A4-4;Q7Z7A4-6;Q7Z7A4-2;Q7Z7A4-7;Q7Z7A4-5;Q7Z7A4-3 ENST00000302779;ENST00000356151;ENST00000383715;ENST00000383716 7 0.74061 1.2914 0.79502 0.95663 0.89799 0.95748 Stathmin cell part;cytoplasm;cytoskeletal part;intracellular organelle part;intracellular part;microtubule;organelle part binding;cytoskeletal protein binding;molecular transducer activity;protein binding;signal transducer activity;tubulin binding cell communication;cytoskeleton organization;microtubule cytoskeleton organization;microtubule depolymerization;microtubule-based process;mitotic spindle organization;organelle organization;signal transduction;spindle organization MAPK signaling pathway 14 14 14 64.4 64.4 64.4 17.302 6.0074E-151 3979000000 2032100000 1946900000 5054 IPI:IPI00479997.4;IPI:IPI00218667.2 Stathmin;Phosphoprotein p19;Leukemia-associated phosphoprotein p18;Oncoprotein 18;pp17;Prosolin;Metablastin;Protein Pr22 STMN1;LAP18;OP18 P16949 ENST00000357865;ENST00000374291;ENST00000399727;ENST00000399728 K04381 2 0.84745 1.8171 0.746 1.153 1.1329 0.9978 Erf4 cell part;cytoplasmic part;Golgi apparatus part;Golgi membrane;intracellular organelle part;intracellular part;membrane;organelle membrane;organelle part 2 2 2 16.1 16.1 16.1 15.824 0.00012146 17362000 9275200 8087000 5055 IPI:IPI00480022.1 Golgin subfamily A member 7;Golgi complex-associated protein of 16 kDa GOLGA7;GCP16;HDCKB03P;HSPC041 Q7Z5G4 ENST00000276530;ENST00000357743;ENST00000405786 1 NaN 1.1452 NaN NaN 0.7032 NaN Exo_endo_phos;RhoGAP cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;Golgi stack;Golgi-associated vesicle;intracellular membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;membrane-bounded vesicle;organelle;organelle part;vesicle catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;inositol or phosphatidylinositol phosphatase activity;phosphatase activity;phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity biological regulation;cell communication;cellular process;lipid metabolic process;metabolic process;primary metabolic process;regulation of biological process;regulation of cellular process;signal transduction Inositol phosphate metabolism;Phosphatidylinositol signaling system 2 2 2 3.1 3.1 3.1 104.2 6.67E-07 889470 447580 441890 5056 IPI:IPI00873093.1;IPI:IPI00480049.2 Inositol polyphosphate 5-phosphatase OCRL-1;Lowe oculocerebrorenal syndrome protein OCRL;INPP5F;OCRL1 Q01968-1;Q01968;Q01968-2 ENST00000357121;ENST00000371113 K01099 2 NaN 1.4955 0.57035 NaN 0.99271 0.74954 Ras cell part;cytoplasm;intracellular part;membrane binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleotide binding;pyrophosphatase activity cell communication;cellular process;establishment of protein localization;intracellular signaling cascade;protein transport;regulation of biological process;signal transduction;small GTPase mediated signal transduction;transport 4 2 2 22 10.6 10.6 24.389 1.8203E-66 6110800 3622100 2488700 5057 IPI:IPI00480056.8 Ras-related protein Rab-4A RAB4A;RAB4 P20338 ENST00000366690 K07879 1 0.3881 NaN NaN 0.55317 NaN NaN PB1;Pkinase cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle catalytic activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;receptor signaling protein serine/threonine kinase activity activation of JUN kinase activity;activation of MAPK activity;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;regulation of protein amino acid phosphorylation Gap junction;GnRH signaling pathway;MAPK signaling pathway 8 8 7 13.9 13.9 12.4 69.74 1.1309E-12 19365000 12616000 6749000 5059 IPI:IPI00513803.3 Mitogen-activated protein kinase kinase kinase 2;MAPK/ERK kinase kinase 2 MAP3K2;MAPKKK2;MEKK2 Q9Y2U5 ENST00000344908;ENST00000409179;ENST00000409947 K04420 1 0.69585 1.2794 0.64554 0.92809 0.80613 0.8519 SWIB cell part;chromatin remodeling complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex;SWI/SNF complex;SWI/SNF-type complex binding;protein binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding;transcription regulator activity chromatin organization;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 13 13 9 31.2 31.2 21.7 54.253 9.2813E-91 306360000 165270000 141090000 5060 IPI:IPI00514042.1;IPI:IPI00853043.1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2;60 kDa BRG-1/Brm-associated factor subunit B;BRG1-associated factor 60B SMARCD2;BAF60B;PRO2451 Q92925-2;Q92925;Q92925-1 ENST00000225742;ENST00000323347 2 0.89498 1.7387 0.9495 1.181 1.1518 1.2445 Adap_comp_sub AP-type membrane coat adaptor complex;clathrin adaptor complex;COPI vesicle coat;cytoplasmic vesicle part;cytosol;Golgi apparatus part;intracellular part;macromolecular complex;membrane coat;membrane part;organelle part;protein complex;vesicle coat binding;protein binding cellular component organization;cellular process;intracellular protein transport;organelle organization;protein transport;retrograde vesicle-mediated transport, Golgi to ER;transport;vesicle coating;vesicle organization;vesicle-mediated transport 27 27 27 50.3 50.3 50.3 57.21 0 1103500000 544990000 558540000 5061 IPI:IPI00514053.1 Coatomer subunit delta;Delta-coat protein ARCN1;COPD P48444 ENST00000264028;ENST00000359415 1 0.5538 1.678 0.60364 0.86639 0.96399 0.88445 Drf_DAD;Drf_FH3;Drf_GBD;FH2 cell part;cytoplasmic part;cytosol;early endosome;endosome;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle actin binding;binding;cytoskeletal protein binding;enzyme binding;GTPase binding;protein binding;Ras GTPase binding;receptor binding;Rho GTPase binding;small GTPase binding actin filament-based process;cellular component organization;cellular process;cytokinesis;cytoskeleton organization;female gamete generation;gamete generation;multicellular organismal development;organelle organization;reproductive process Regulation of actin cytoskeleton 7 7 7 7.9 7.9 7.9 125.48 1.0946E-41 47594000 25850000 21744000 5062 IPI:IPI00844377.2;IPI:IPI00844086.1;IPI:IPI00514075.5 Protein diaphanous homolog 2;Diaphanous-related formin-2 DIAPH2;DIA O60879-1;O60879;O60879-3;O60879-2 ENST00000324765;ENST00000355827;ENST00000373049;ENST00000373054 K05741 3 0.71366 1.377 0.68418 0.91275 0.87038 0.86055 GDE_C cell part;cytoplasmic part;cytosol;intracellular part;isoamylase complex;macromolecular complex;protein complex 4-alpha-glucanotransferase activity;amylo-alpha-1,6-glucosidase activity;binding;catalytic activity;glucosidase activity;glycogen debranching enzyme activity;hydrolase activity, hydrolyzing O-glycosyl compounds;transferase activity carbohydrate metabolic process;cellular glucan metabolic process;generation of precursor metabolites and energy;glycogen biosynthetic process;glycogen metabolic process;polysaccharide biosynthetic process;polysaccharide metabolic process Starch and sucrose metabolism 22 22 22 19 19 19 174.76 2.2163E-191 319740000 173400000 146340000 5063 IPI:IPI00514126.2;IPI:IPI00219066.5;IPI:IPI00219065.2 Glycogen debranching enzyme;Glycogen debrancher;4-alpha-glucanotransferase;Oligo-1,4-1,4-glucantransferase;Amylo-alpha-1,6-glucosidase;Dextrin 6-alpha-D-glucosidase AGL;GDE P35573-1;P35573;P35573-3;P35573-2 ENST00000294724;ENST00000311030;ENST00000361302;ENST00000361522;ENST00000361915;ENST00000370161;ENST00000370163;ENST00000370165 K00705;K01196 3 0.69499 1.265 NaN 0.87746 0.85578 NaN Myosin_head;Myosin_N;Myosin_tail_1 adherens junction;cell junction;cell-substrate adherens junction;cell-substrate junction;focal adhesion;macromolecular complex;muscle myosin complex;myosin complex;myosin filament;myosin II complex;nucleolus;organelle;striated muscle thick filament actin binding;ATP binding;binding;calmodulin binding;catalytic activity;cytoskeletal protein binding;microfilament motor activity;motor activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;structural molecule activity cytoskeleton organization;in utero embryonic development;muscle contraction;muscle system process;organelle organization;regulation of heart rate;regulation of the force of heart contraction;striated muscle contraction;system process;transport Tight junction 3 1 1 1.7 0.9 0.9 223.73 0.00011925 9898500 5422100 4476500 5065 IPI:IPI00514201.3 Myosin-6;Myosin heavy chain 6;Myosin heavy chain, cardiac muscle alpha isoform MYH6;MYHCA P13533 ENST00000356287;ENST00000405093 K10352 1 1.0054 1.2318 1.0426 1.2577 0.84699 1.2863 Mob1_phocein cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;enzyme activator activity;enzyme binding;enzyme regulator activity;ion binding;kinase activator activity;kinase binding;kinase regulator activity;metal ion binding;protein binding;transition metal ion binding;zinc ion binding cellular biopolymer metabolic process;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process Cell cycle - yeast 7 1 1 29.2 3.2 3.2 25.091 7.7505E-38 1017900 493930 524020 5066 IPI:IPI00514212.3 Mps one binder kinase activator-like 1A;Mob1 homolog 1A;Mob1B;Protein Mob4A MOBKL1A;MOB4A Q7L9L4 ENST00000309395;ENST00000396051 K06685 1 0.676 1.3282 0.69958 0.87636 0.91687 0.87969 KOW intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;mitochondrion;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 6 6 6 33.8 33.8 33.8 24.915 3.3023E-40 92656000 50463000 42193000 5068 IPI:IPI00514506.3 39S ribosomal protein L24, mitochondrial;MRP-L24 MRPL24 Q96A35 ENST00000361531;ENST00000368211 1 0.61702 1.4596 NaN 0.7919 0.96493 NaN Nnf1 cell part;chromosomal part;intracellular organelle part;intracellular part;macromolecular complex;MIS12/MIND type complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex binding;protein binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding;transcription regulator activity nitrogen compound metabolic process;nuclear division;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent 2 2 2 11.6 11.6 11.6 22.946 2.9474E-07 6207100 3329500 2877600 5069 IPI:IPI00514558.3;IPI:IPI00549361.4;IPI:IPI00784746.1 Polyamine-modulated factor 1 PMF1 Q6P1K2-2;Q6P1K2;Q6P1K2-1;Q6P1K2-4 ENST00000320139;ENST00000368273;ENST00000368276;ENST00000368277 K11546 3 0.97506 1.5651 0.98335 1.2083 1.1233 1.2344 HEAT cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding establishment of localization;establishment of protein localization;protein transport;transport 4 2 2 3.5 1.8 1.8 124.71 5.4074E-07 60693000 31184000 29509000 5070 IPI:IPI00514622.2 Ran-binding protein 6 RANBP6 O60518 ENST00000259569 1 0.88649 2.7322 NaN 1.122 1.7396 NaN cell part;cytoplasm;intracellular part ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups mRNA catabolic process;nuclear-transcribed mRNA catabolic process;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein modification process;RNA catabolic process 4 4 4 6.6 6.6 6.6 82.18 2.1126E-22 6587500 4846400 1741100 5071 IPI:IPI00514774.4;IPI:IPI00513919.5;IPI:IPI00829672.1 PAB-dependent poly(A)-specific ribonuclease subunit 3 PAN3 Q58A45-1;Q58A45;Q58A45-3;Q58A45-2 ENST00000282391;ENST00000380958;ENST00000399620 3 0.071404 NaN NaN 0.095388 NaN NaN cell part;cytoplasm;intracellular part 6 6 6 10.2 10.2 10.2 64.135 1.3639E-25 34652000 27775000 6876300 5072 IPI:IPI00514908.1 Keratinocyte proline-rich protein KPRP;C1orf45 Q5T749 ENST00000368773;ENST00000392673 1 1.0336 1.9098 0.97247 1.4435 1.2562 1.1962 OST3_OST6 cell part;cytoplasmic part;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;macromolecular complex;membrane part;oligosaccharyltransferase complex;organelle part;protein complex carbohydrate metabolic process;cellular process;metabolic process;peptidyl-amino acid modification;peptidyl-asparagine modification;protein amino acid glycosylation;protein amino acid N-linked glycosylation;protein modification process 5 5 5 15.2 15.2 15.2 38.036 4.8318E-18 259010000 129520000 129490000 5073 IPI:IPI00515117.5 Magnesium transporter protein 1;Implantation-associated protein MAGT1;IAG2;PSEC0084;UNQ628/PRO1244 Q9H0U3 ENST00000358075;ENST00000395579 1 0.72348 1.4714 0.8534 0.95645 0.97779 1.0805 zf-C2H2 cell part;chromosomal part;intracellular organelle part;intracellular part;macromolecular complex;nuclear chromosome part;nuclear origin of replication recognition complex;nuclear part;organelle part;origin recognition complex;protein complex binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding biosynthetic process;cellular process;DNA metabolic process;DNA replication;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 4 4 4 9.5 9.5 9.5 63.574 6.8789E-50 11910000 6633600 5276700 5074 IPI:IPI00549171.5 Replication initiator 1;Zinc finger protein 464;DHFR oribeta-binding protein RIP60;60 kDa replication initiation region protein;60 kDa origin-specific DNA-binding protein;ATT-binding protein REPIN1;RIP60;ZNF464 Q9BWE0 ENST00000397281 1 0.67959 1.2835 0.62491 0.86502 0.85611 0.82198 Peptidase_M3 cell part;cytoplasm;intracellular part binding;catalytic activity;cation binding;endopeptidase activity;hydrolase activity;ion binding;metal ion binding;metalloendopeptidase activity;metallopeptidase activity;peptidase activity;protein binding;transition metal ion binding;zinc ion binding biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis Renin-angiotensin system 15 15 15 23.2 23.2 23.2 78.839 4.2478E-140 982440000 531100000 451350000 5075 IPI:IPI00549189.4 Thimet oligopeptidase;Endopeptidase 24.15;MP78 THOP1 P52888 ENST00000307741 K01392 1 0.65833 2.0147 0.67234 0.95514 1.197 0.95158 DUF1640 cell part;cytoplasmic part;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane part;membrane-bounded organelle;mitochondrion;organelle 2 2 2 12.2 12.2 12.2 29.471 0.00016018 19219000 10240000 8979300 5076 IPI:IPI00549236.2;IPI:IPI00854851.1 Coiled-coil domain-containing protein 90B, mitochondrial CCDC90B;CUA003;MDS011;MDS025 Q9GZT6-1;Q9GZT6;Q9GZT6-2 ENST00000260054 2 0.7316 1.383 0.7443 0.94936 0.98628 0.99883 DAO cell part;cytoplasmic part;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane part;membrane-bounded organelle;mitochondrion;organelle binding;catalytic activity;oxidoreductase activity;protein binding metabolic process;oxidation reduction 6 6 6 14.4 14.4 14.4 53.811 1.3154E-78 54409000 29077000 25332000 5078 IPI:IPI00549357.3;IPI:IPI00827653.1 FAD-dependent oxidoreductase domain-containing protein 1 FOXRED1;FP634 Q96CU9-1;Q96CU9;Q96CU9-2 ENST00000263578 2 0.68184 1.8232 0.79377 0.9643 1.1578 1.0473 Ribosomal_L1 binding;nucleic acid binding;RNA binding cellular biopolymer metabolic process;cellular process;macromolecule metabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing 10 10 10 39.1 39.1 39.1 36.908 6.9726E-113 321040000 170250000 150790000 5079 IPI:IPI00549381.5 39S ribosomal protein L1, mitochondrial MRPL1;BM-022 Q9BYD6 ENST00000315567;ENST00000335904 1 0.91984 1.1518 0.77866 1.1682 0.80332 0.97577 DUF858 binding;catalytic activity;methyltransferase activity;protein binding;transferase activity;transferase activity, transferring one-carbon groups 5 5 5 29.9 29.9 29.9 25.474 5.2892E-71 65590000 33901000 31688000 5080 IPI:IPI00549389.3 Methyltransferase-like protein 11A METTL11A;C9orf32;AD-003 Q9BV86 ENST00000372480;ENST00000372483;ENST00000372486 1 0.73769 1.7103 0.9066 1.0123 1.0965 1.2065 CN_hydrolase catalytic activity;hydrolase activity;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds metabolic process;nitrogen compound metabolic process 14 14 14 52.9 52.9 52.9 30.608 4.2023E-246 319760000 160410000 159350000 5081 IPI:IPI00549467.3 Nitrilase homolog 2 NIT2;CUA002 Q9NQR4 ENST00000265259;ENST00000394140 1 0.52576 0.99603 0.52072 0.65307 0.68369 0.65652 CAF1;zf-CCCH cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear body;nuclear part;nuclear speck;nucleolus;nucleoplasm part;organelle;organelle part binding;cation binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding 6 6 6 15.1 15.1 15.1 56.547 2.1201E-43 60508000 31659000 28850000 5082 IPI:IPI00549516.3 Target of EGR1 protein 1 TOE1 Q96GM8 ENST00000372090 1 0.47718 1.0709 0.48969 0.63656 0.69377 0.61407 WD40 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part negative regulation of biological process;negative regulation of cell communication;negative regulation of cellular process;negative regulation of signal transduction;regulation of cell communication;regulation of signal transduction 9 9 9 27.3 27.3 27.3 43.963 7.6503E-45 69739000 38797000 30942000 5083 IPI:IPI00549540.3 p21-activated protein kinase-interacting protein 1;PAK1-interacting protein 1;PAK/PLC-interacting protein 1;WD repeat-containing protein 84 PAK1IP1;PIP1;WDR84 Q9NWT1 ENST00000379568 1 0.77314 1.3302 0.79559 0.97403 0.94306 0.98616 Neurochondrin cell part;cell projection;cytoplasm;dendrite;intracellular part;neuron projection 3 3 3 5.3 5.3 5.3 79.157 2.2504E-32 5878400 3225700 2652700 5084 IPI:IPI00889000.1;IPI:IPI00549543.1;IPI:IPI00555661.1 Neurochondrin NCDN;KIAA0607 Q9UBB6-3;Q9UBB6;Q9UBB6-1;Q9UBB6-2 ENST00000356090;ENST00000373243;ENST00000397922 3 0.97058 1.5915 0.93996 1.1934 1.12 1.2377 DALR_1;tRNA-synt_1d cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part aminoacyl-tRNA ligase activity;arginine-tRNA ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-oxygen bonds;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding arginyl-tRNA aminoacylation;cellular amino acid and derivative metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;tRNA aminoacylation for protein translation;tRNA metabolic process Aminoacyl-tRNA biosynthesis 7 7 7 13.3 13.3 13.3 65.505 5.003E-89 10260000 5711300 4548500 5085 IPI:IPI00549566.4 Probable arginyl-tRNA synthetase, mitochondrial;Arginine--tRNA ligase;Arginyl-tRNA synthetase-like RARS2;RARSL Q5T160 ENST00000369536;ENST00000392851 K01887 1 NaN 1.2809 0.5729 NaN 0.82661 0.76247 HEAT integral to membrane;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane;membrane part;non-membrane-bounded organelle;nuclear membrane;nucleolus;organelle;organelle membrane;organelle part binding 5 5 5 6.1 6.1 6.1 105.67 9.0666E-49 5396700 3112900 2283800 5086 IPI:IPI00549664.4 Testis-expressed sequence 10 protein TEX10;L18;Nbla10363 Q9NXF1 ENST00000374902 1 0.82648 1.7513 0.86306 1.0894 1.1576 1.1267 PCI cell part;cytoplasmic part;cytosol;intracellular part;macromolecular complex;proteasome regulatory particle;protein complex binding;protein binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Proteasome 22 22 22 61.5 61.5 61.5 42.671 0 2914800000 1549600000 1365200000 5087 IPI:IPI00549672.2 26S proteasome non-ATPase regulatory subunit 13;26S proteasome regulatory subunit S11;26S proteasome regulatory subunit p40.5 PSMD13 Q9UNM6 ENST00000352303 K03039 1 0.82492 1.6977 0.85067 1.0733 1.1207 1.0729 PGAM cell part;cytoplasmic part;cytosol;intracellular part 2,3-bisphospho-D-glycerate 2-phosphohydrolase activity;binding;bisphosphoglycerate mutase activity;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;phosphatase activity;phosphoglycerate mutase activity;protein binding alcohol metabolic process;carbohydrate metabolic process;generation of precursor metabolites and energy;glucose catabolic process;glucose metabolic process;glycolysis;monosaccharide metabolic process;regulation of carbohydrate metabolic process Glycolysis / Gluconeogenesis 22 22 22 79.1 79.1 79.1 28.804 0 10943000000 5686500000 5256300000 5088 IPI:IPI00549725.6;IPI:IPI00374975.2;IPI:IPI00218570.6 Phosphoglycerate mutase 1;Phosphoglycerate mutase isozyme B;BPG-dependent PGAM 1 PGAM1;PGAMA;CDABP0006 P18669 ENST00000334828;ENST00000402426 K01834 3 0.82683 1.5232 0.78278 1.0283 1.0202 0.99313 Aldolase_II cell part;cytoplasm;intracellular part binding;cation binding;identical protein binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding apoptosis;cell death;cellular process;death;programmed cell death Methionine metabolism 9 9 9 45 45 45 27.125 9.5361E-168 262820000 144110000 118710000 5089 IPI:IPI00549730.3 APAF1-interacting protein APIP;CGI-29 Q96GX9 ENST00000278359;ENST00000395786 K08964 1 NaN 1.0791 0.43284 NaN 0.66107 0.58751 Glycos_transf_1 cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part catalytic activity;chitobiosyldiphosphodolichol beta-mannosyltransferase activity;mannosyltransferase activity;transferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring hexosyl groups carbohydrate metabolic process;lipid biosynthetic process;lipid metabolic process;metabolic process;polysaccharide biosynthetic process;polysaccharide metabolic process;protein amino acid glycosylation;protein modification process N-Glycan biosynthesis 3 3 3 8.4 8.4 8.4 52.518 1.297E-75 34193000 19751000 14442000 5090 IPI:IPI00549761.3;IPI:IPI00145612.7 Chitobiosyldiphosphodolichol beta-mannosyltransferase;GDP-mannose-dolichol diphosphochitobiose mannosyltransferase;GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase;Beta-1,4-mannosyltransferase;Mannosyltransferase-1;Hmat-1;Asparagine-linked glycosylation protein 1 ALG1;HMAT1;HMT1;PSEC0061;UNQ861/PRO1870 Q9BT22 ENST00000262374 K03842 2 0.77441 1.5185 NaN 0.95582 1.0519 NaN N1221 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 2 2 2 2.4 2.4 2.4 95.575 1.2429E-11 1564400 909360 655040 5092 IPI:IPI00549766.2;IPI:IPI00619947.1;IPI:IPI00939477.1;IPI:IPI00005300.4;IPI:IPI00470377.1 Protein FAM40A;Protein FAM40B FAM40A;KIAA1761;FAM40B;KIAA1170 Q5VSL9-1;Q5VSL9;Q5VSL9-2;Q9ULQ0-1;Q9ULQ0;Q9ULQ0-2;Q5VSL9-4 ENST00000369794;ENST00000369795;ENST00000249344 5 0.85733 1.9077 0.90544 1.1248 1.2632 1.18 HS2ST cell part;cytoplasmic part;Golgi apparatus part;Golgi membrane;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part catalytic activity;transferase activity Heparan sulfate biosynthesis 5 5 5 15.4 15.4 15.4 41.881 1.4647E-52 88401000 45911000 42490000 5093 IPI:IPI00549891.3;IPI:IPI00040900.3;IPI:IPI00552241.1 Heparan sulfate 2-O-sulfotransferase 1 HS2ST1;HS2ST;KIAA0448 Q7LGA3-1;Q7LGA3;Q7LGA3-2;Q7LGA3-3 ENST00000370550 K02513 3 0.70404 1.4248 0.72611 0.94453 0.9358 0.97268 LIM binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding 2 2 2 23.6 23.6 23.6 14.07 2.5232E-137 159650000 84425000 75226000 5094 IPI:IPI00549972.3 LIM domain-containing protein 2 LIMD2;SB143 Q9BT23 ENST00000259006 1 0.72826 1.3873 0.69322 0.93674 0.91024 0.95731 Ribosomal_L3 cytosolic large ribosomal subunit;intracellular non-membrane-bounded organelle;intracellular organelle;large ribosomal subunit;macromolecular complex;non-membrane-bounded organelle;nucleolus;organelle;ribonucleoprotein complex;ribosomal subunit binding;nucleic acid binding;protein binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 20 20 20 41.9 41.9 41.9 46.108 0 7826300000 4348800000 3477500000 5096 IPI:IPI00550021.4;IPI:IPI00219335.10 60S ribosomal protein L3;HIV-1 TAR RNA-binding protein B RPL3;OK/SW-cl.32 P39023 ENST00000216146 K02925 2 0.71463 1.5678 0.76625 0.9592 1.0945 0.99287 Ribosomal_S15 cytoplasmic part;intracellular part;macromolecular complex;mitochondrial part;mitochondrial small ribosomal subunit;organellar small ribosomal subunit;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 6 6 6 20.2 20.2 20.2 29.842 1.0144E-24 164280000 90969000 73314000 5097 IPI:IPI00550037.3 28S ribosomal protein S15, mitochondrial;MRP-S15 MRPS15;RPMS15;DC37 P82914 ENST00000373116 1 0.53821 1.1187 0.56749 0.67732 0.73827 0.71965 LRR_1 angiogenin-PRI complex;cell part;cytoplasm;extracellular region part;intracellular part;macromolecular complex;protein complex binding;enzyme inhibitor activity;enzyme regulator activity;protein binding;ribonuclease inhibitor activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;mRNA catabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA catabolic process 20 20 20 66.8 66.8 66.8 49.973 0 1749700000 963850000 785890000 5098 IPI:IPI00550069.3 Ribonuclease inhibitor;Ribonuclease/angiogenin inhibitor 1;Placental ribonuclease inhibitor RNH1;PRI;RNH P13489 ENST00000354420;ENST00000356187;ENST00000397604;ENST00000397614;ENST00000397615 1 0.74942 1.7217 NaN 1.0274 1.1501 NaN adh_short integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intrinsic to membrane;membrane;membrane-bounded organelle;microbody;microbody membrane;organelle;organelle membrane;organelle part;peroxisomal membrane binding;catalytic activity;oxidoreductase activity metabolic process;oxidation reduction 3 3 3 8.6 8.6 8.6 35.119 7.9829E-101 3171000 1819200 1351800 5099 IPI:IPI00550165.4 Dehydrogenase/reductase SDR family member 7B DHRS7B;CGI-93;UNQ212/PRO238 Q6IAN0 ENST00000346603 K11166 1 0.80055 NaN NaN 1.1781 NaN NaN Snf7 cell part;cytoplasmic part;cytosol;endosomal part;endosome membrane;intracellular organelle part;intracellular part;late endosome membrane;membrane;organelle membrane;organelle part binding;protein binding;protein domain specific binding establishment of localization;establishment of protein localization;protein transport;transport 3 3 3 20.2 20.2 20.2 23.906 1.1271E-05 17904000 10776000 7128300 5100 IPI:IPI00550181.2 Charged multivesicular body protein 2b;Chromatin-modifying protein 2b;CHMP2.5;Vacuolar protein-sorting-associated protein 2-2 CHMP2B;CGI-84 Q9UQN3 ENST00000263780 K12192 1 0.79012 1.5554 0.77218 1.007 1.0371 0.94424 Hep_59 6 6 6 27.3 27.3 27.3 33.688 2.2437E-90 370640000 186410000 184230000 5101 IPI:IPI00550191.2 Uncharacterized protein C9orf78;Hepatocellular carcinoma-associated antigen 59 C9orf78;HCA59 Q9NZ63 ENST00000372447 1 0.96551 1.8523 0.92444 1.2478 1.1968 1.1869 AMP_N;Peptidase_M24 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;nucleus;organelle aminopeptidase activity;binding;catalytic activity;cation binding;exopeptidase activity;hydrolase activity;ion binding;manganese ion binding;metal ion binding;metallopeptidase activity;peptidase activity;transition metal ion binding cellular process 5 5 5 12.6 12.6 12.6 57.033 2.3726E-125 62050000 31712000 30337000 5102 IPI:IPI00550192.2;IPI:IPI00795212.1 Probable Xaa-Pro aminopeptidase 3;Aminopeptidase P3 XPNPEP3 Q9NQH7-1;Q9NQH7;Q9NQH7-2 ENST00000357137 K01262 2 0.98323 1.9953 1.1047 1.288 1.3452 1.414 P16-Arc Arp2/3 protein complex;cell part;cell projection;cytoplasm;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;organelle part;protein complex actin binding;binding;cytoskeletal protein binding;protein binding;structural constituent of cytoskeleton;structural molecule activity actin filament-based process;cell motion;cellular component organization;cellular process;cytoskeleton organization;organelle organization;regulation of actin polymerization or depolymerization;regulation of metabolic process Regulation of actin cytoskeleton 4 4 4 33.1 33.1 33.1 16.32 2.6882E-69 825610000 417320000 408290000 5104 IPI:IPI00550234.4;IPI:IPI00007280.10 Actin-related protein 2/3 complex subunit 5;Arp2/3 complex 16 kDa subunit ARPC5;ARC16 O15511-1;O15511;O15511-2 ENST00000294742;ENST00000359856 K05754 2 0.84312 1.6897 0.77521 1.0974 1.1396 1.0368 THUMP 10 10 10 26.9 26.9 26.9 39.315 8.148E-199 249510000 128350000 121170000 5105 IPI:IPI00550243.2 THUMP domain-containing protein 1 THUMPD1 Q9NXG2 ENST00000381337;ENST00000396083 K06963 1 0.60035 0.95802 0.47103 0.75699 0.66125 0.57992 cell part;integrator complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;protein binding cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;snRNA metabolic process;snRNA processing 9 9 9 15.4 15.4 15.4 82.235 4.1591E-47 32704000 17803000 14901000 5106 IPI:IPI00550272.3 Integrator complex subunit 10 INTS10;C8orf35 Q9NVR2 ENST00000397977 1 0.85279 1.3839 0.88426 1.0845 0.98336 1.0939 RRM_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding 17 17 17 20.1 20.1 20.1 97.394 4.6155E-40 645440000 341250000 304190000 5108 IPI:IPI00550308.1 RNA-binding protein 12;RNA-binding motif protein 12;SH3/WW domain anchor protein in the nucleus RBM12;KIAA0765;HRIHFB2091 Q9NTZ6 ENST00000359646;ENST00000374104;ENST00000374114 1 NaN 0.20381 NaN NaN 0.15049 NaN HemN_C;Radical_SAM cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle binding;catalytic activity;coproporphyrinogen oxidase activity;iron ion binding;oxidoreductase activity;oxidoreductase activity, acting on the CH-CH group of donors;oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor biosynthetic process;cellular process;heterocycle biosynthetic process;metabolic process;nitrogen compound metabolic process;porphyrin biosynthetic process;porphyrin metabolic process;tetrapyrrole biosynthetic process;tetrapyrrole metabolic process 3 3 3 7.9 7.9 7.9 48.713 1.2879E-27 11409000 2740600 8668300 5109 IPI:IPI00550335.4 Radical S-adenosyl methionine domain-containing protein 1, mitochondrial;Oxygen-independent coproporphyrinogen-III oxidase-like protein RSAD1 RSAD1 Q9HA92 ENST00000258955 1 0.70357 1.3156 0.7188 0.89764 0.89466 0.92977 Calponin;CH cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane;non-membrane-bounded organelle;nuclear membrane;nuclear part;organelle;organelle membrane;organelle part;plasma membrane binding;protein binding anatomical structure development;developmental process;muscle organ development;organ development 17 17 17 84.9 84.9 84.9 22.391 0 5579300000 2953100000 2626200000 5110 IPI:IPI00550363.3 Transgelin-2;SM22-alpha homolog TAGLN2;KIAA0120;CDABP0035 P37802 ENST00000320307;ENST00000368096;ENST00000368097 1 0.76389 1.4647 0.77761 1.0262 0.97063 0.98388 PGM_PMM_I;PGM_PMM_II cell part;cytoplasm;intracellular part binding;catalytic activity;cation binding;intramolecular transferase activity;intramolecular transferase activity, phosphotransferases;ion binding;isomerase activity;magnesium ion binding;metal ion binding;phosphoglucomutase activity alcohol metabolic process;carbohydrate metabolic process;glucose metabolic process;hexose metabolic process;metabolic process;monosaccharide metabolic process;primary metabolic process Galactose metabolism;Glycolysis / Gluconeogenesis;Pentose phosphate pathway;Starch and sucrose metabolism;Streptomycin biosynthesis 23 23 22 41.2 41.2 40.2 68.283 0 1442400000 785580000 656850000 5111 IPI:IPI00550364.8 Phosphoglucomutase-2;Glucose phosphomutase 2 PGM2;MSTP006 Q96G03 ENST00000381967 K01835 1 0.79893 1.3047 0.81178 1.0493 0.90366 1.0147 Metallophos cell part;cytoplasm;histone methyltransferase complex;intracellular organelle part;intracellular part;macromolecular complex;methyltransferase complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;iron ion binding;manganese ion binding;phosphatase activity;phosphoprotein phosphatase activity;protein binding;protein serine/threonine phosphatase activity carbohydrate metabolic process;cellular glucan metabolic process;energy reserve metabolic process;generation of precursor metabolites and energy;glycogen metabolic process;polysaccharide metabolic process;protein modification process 23 23 6 63.6 63.6 16.1 37.512 0 3431500000 1756600000 1674800000 5114 IPI:IPI00550451.1 Serine/threonine-protein phosphatase PP1-alpha catalytic subunit PPP1CA;PPP1A P62136 ENST00000312989;ENST00000376745 1 0.73237 1.4332 NaN 0.98879 0.91962 NaN zf-C3HC4 cell part;cytoplasm;intracellular part binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding positive regulation of biosynthetic process;positive regulation of metabolic process;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process 3 3 3 8.3 8.3 8.3 90.496 1.3951E-28 18587000 8943800 9643400 5115 IPI:IPI00939548.1;IPI:IPI00550496.4 RING finger protein 10 RNF10;KIAA0262;RIE2 Q8N5U6-2;Q8N5U6;Q8N5U6-1 ENST00000325954 2 0.85069 1.7614 0.80529 1.1413 1.1281 1.0209 GBP cell part;integral to membrane;intrinsic to membrane;membrane part binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleotide binding;pyrophosphatase activity 16 16 16 39.7 39.7 39.7 60.541 0 651730000 348790000 302940000 5116 IPI:IPI00550523.5;IPI:IPI00845461.2 Atlastin-3 ATL3 Q6DD88-1;Q6DD88;Q6DD88-2 ENST00000332645;ENST00000398868 2 0.73286 1.1056 0.57243 0.94966 0.74393 0.76948 RNA_pol_I_A49 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;catalytic activity;DNA binding;DNA-directed RNA polymerase activity;nucleic acid binding;nucleotidyltransferase activity;protein binding;RNA polymerase activity;transferase activity;transferase activity, transferring phosphorus-containing groups biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;rRNA transcription;transcription;transcription, DNA-dependent RNA polymerase 8 8 8 19.8 19.8 19.8 47.26 8.4631E-33 86196000 46012000 40184000 5117 IPI:IPI00550638.2;IPI:IPI00251989.2 DNA-directed RNA polymerase I subunit RPA49;DNA-directed RNA polymerase I subunit E;RNA polymerase I-associated factor 1;RNA polymerase I-associated factor 53 POLR1E;PAF53;PRAF1 Q9GZS1-2;Q9GZS1;Q9GZS1-1 ENST00000377792;ENST00000377798 K03005 2 0.88214 1.7952 0.75459 1.1882 1.1587 1.0261 Spin-Ssty cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle cell cycle;cellular process;developmental process;gamete generation;multicellular organismal development;multicellular organismal process;reproductive process 3 3 3 15.3 15.3 15.3 29.6 4.3052E-18 28401000 14019000 14382000 5118 IPI:IPI00550655.4;IPI:IPI00174535.7 Spindlin-1;Ovarian cancer-related protein SPIN1;OCR;SPIN Q9Y657 ENST00000375859;ENST00000404529 2 0.80893 1.5752 0.77314 1.0411 1.0136 1.0138 UPF0027 binding;cytoskeletal protein binding;protein binding;vinculin binding anatomical structure morphogenesis;biological adhesion;cell adhesion;cell morphogenesis;cell morphogenesis involved in differentiation;cell-matrix adhesion;cell-substrate adhesion;cellular component organization;cellular process;developmental process 20 20 20 49.9 49.9 49.9 55.21 0 2968700000 1581500000 1387200000 5119 IPI:IPI00550689.3 UPF0027 protein C22orf28 C22orf28;HSPC117 Q9Y3I0 ENST00000216038 1 1.0596 2.2272 1.0772 1.4621 1.3858 1.516 CS cell part;cytoplasm;cytoskeletal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;microtubule;nucleus;organelle;organelle part binding;protein binding cell cycle phase;cell cycle process;cell proliferation;cellular component organization;cellular process;developmental process;mitosis;multicellular organismal development;multicellular organismal process;nuclear division;organelle organization 27 27 27 66.2 66.2 66.2 38.242 0 5079100000 2485800000 2593300000 5120 IPI:IPI00550746.4 Nuclear migration protein nudC;Nuclear distribution protein C homolog NUDC Q9Y266 ENST00000321265 1 0.56574 1.1176 0.63672 0.72844 0.77526 0.77552 Nop52 intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nucleolus;organelle;organelle part;preribosome;preribosome, small subunit precursor;ribonucleoprotein complex cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 9 9 9 19.1 19.1 19.1 52.839 6.9817E-54 260880000 140910000 119970000 5121 IPI:IPI00550766.1 Ribosomal RNA processing protein 1 homolog A;RRP1-like protein;Novel nuclear protein 1;Nucleolar protein Nop52 RRP1;D21S2056E;NNP1;NOP52;RRP1A P56182 ENST00000400387 1 0.61471 1.6888 0.76127 0.78223 1.1426 0.94166 5 5 5 12.6 12.6 12.6 55.046 1.9521E-168 90424000 50695000 39729000 5122 IPI:IPI00550772.5;IPI:IPI00384112.5;IPI:IPI00015860.4 Uncharacterized protein C12orf41 C12orf41 Q9H9L4-1;Q9H9L4;Q9H9L4-2;Q9H9L4-3 ENST00000324947;ENST00000357861 3 0.84728 1.5966 0.81082 1.0525 1.0411 1.0552 RRM_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 11 11 11 32.3 32.3 32.3 52.049 6.9878E-128 472100000 247220000 224870000 5124 IPI:IPI00550821.2;IPI:IPI00719106.1 Cleavage and polyadenylation specificity factor subunit 7;Cleavage and polyadenylation specificity factor 59 kDa subunit;Pre-mRNA cleavage factor Im 59 kDa subunit CPSF7 Q8N684-1;Q8N684;Q8N684-2 ENST00000340437;ENST00000394888 2 0.84353 1.5407 0.88544 1.0874 1.0341 1.1282 Dynactin_p62 centrosome;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;microtubule organizing center;non-membrane-bounded organelle;nucleus;organelle;organelle part binding;protein binding;protein N-terminus binding 14 14 14 39.6 39.6 39.6 52.337 1.222E-218 257530000 151920000 105610000 5125 IPI:IPI00550852.4 Dynactin subunit 4;Dynactin subunit p62 DCTN4 Q9UJW0 ENST00000255263 1 NaN NaN 0.5478 NaN NaN 0.70667 Vps39_1;Vps39_2 cell part;cytoplasm;intracellular part;membrane binding;cytokine receptor binding;protein binding;receptor binding;SMAD binding;transforming growth factor beta receptor binding cell communication;cell surface receptor linked signal transduction;enzyme linked receptor protein signaling pathway;signal transduction;transmembrane receptor protein serine/threonine kinase signaling pathway 3 3 3 3.1 3.1 3.1 97.157 3.112E-12 8200500 5064500 3135900 5126 IPI:IPI00550891.3 Transforming growth factor-beta receptor-associated protein 1 TGFBRAP1 Q8WUH2 ENST00000258449;ENST00000393359 1 0.80976 NaN NaN 1.1069 NaN NaN Glucosamine_iso cell part;cytoplasmic part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle catalytic activity;deaminase activity;glucosamine-6-phosphate deaminase activity;hydrolase activity;intramolecular oxidoreductase activity;intramolecular oxidoreductase activity, interconverting aldoses and ketoses;isomerase activity alcohol metabolic process;amino sugar metabolic process;carbohydrate metabolic process;glucosamine metabolic process;metabolic process;monosaccharide metabolic process;N-acetylglucosamine metabolic process;primary metabolic process Aminosugars metabolism 8 1 1 34.8 4.3 4.3 31.084 1.0007E-196 940180 543080 397110 5127 IPI:IPI00550894.4;IPI:IPI00896466.1;IPI:IPI00896510.1 Glucosamine-6-phosphate isomerase 2;Glucosamine-6-phosphate deaminase 2;Glucosamine-6-phosphate isomerase SB52 GNPDA2 Q8TDQ7-1;Q8TDQ7;Q8TDQ7-3;Q8TDQ7-2 ENST00000295448 K02564 3 0.78551 1.6396 0.78328 1.0484 1.0328 1.0386 TCTP cell part;cytoplasmic part;endosome;extracellular region part;extracellular space;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;late endosome;membrane-bounded organelle;multivesicular body;organelle binding;calcium ion binding;cation binding;ion binding;metal ion binding;protein binding anti-apoptosis;calcium ion transport;cation transport;cellular calcium ion homeostasis;cellular ion homeostasis;cellular metal ion homeostasis;cellular process;di-, tri-valent inorganic cation transport;ion transport;regulation of cell death;transport 8 8 8 62.8 62.8 62.8 19.595 3.7535E-227 2929600000 1574700000 1354900000 5128 IPI:IPI00550900.1;IPI:IPI00410496.2 Translationally-controlled tumor protein;p23;Histamine-releasing factor;Fortilin TPT1 P13693 ENST00000309246;ENST00000379060 2 NaN 1.394 0.77522 NaN 0.89164 0.92974 RRM_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;nucleotide binding;RNA binding cellular biopolymer metabolic process;cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing 8 3 3 14.6 4.2 4.2 64.436 8.985E-70 28349000 14468000 13881000 5129 IPI:IPI00550906.6 Cleavage stimulation factor 64 kDa subunit, tau variant;TauCstF-64;CF-1 64 kDa subunit, tau variant CSTF2T;KIAA0689 Q9H0L4 ENST00000331173 1 0.86315 1.5587 0.80792 1.0956 1.005 1.059 Cofilin_ADF cell part;cytoplasmic part;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle;perinuclear region of cytoplasm actin binding;adenyl nucleotide binding;ATP binding;binding;cytoskeletal protein binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding 10 10 9 39.3 39.3 37.2 39.548 0 418460000 216000000 202460000 5130 IPI:IPI00550917.3 Twinfilin-2;Twinfilin-1-like protein;A6-related protein;Protein tyrosine kinase 9-like TWF2;PTK9L;MSTP011 Q6IBS0 ENST00000305533 K08870 1 0.53027 1.0043 0.49455 0.68628 0.66882 0.59997 DUF2151 8 8 8 14.9 14.9 14.9 80.224 3.1621E-50 30760000 16674000 14086000 5131 IPI:IPI00550986.4 Uncharacterized protein C12orf11;Sarcoma antigen NY-SAR-95 C12orf11 Q9NVM9 ENST00000261191 1 0.607 1.3613 0.49966 0.81657 0.91656 0.66021 PIH1 4 4 4 22.4 22.4 22.4 32.363 8.5315E-35 33236000 18215000 15020000 5132 IPI:IPI00550995.2 PIH1 domain-containing protein 1;Nucleolar protein 17 homolog PIH1D1;NOP17 Q9NWS0 ENST00000262265 1 0.95376 1.5661 0.89502 1.2322 1.09 1.1192 PUF cell part;cytoplasm;intracellular part binding;nucleic acid binding;RNA binding posttranscriptional regulation of gene expression;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of metabolic process;regulation of translation 13 13 10 14.9 14.9 12.1 126.47 1.1647E-233 143630000 74122000 69505000 5133 IPI:IPI00551014.1;IPI:IPI00941189.1 Pumilio homolog 1 PUM1;KIAA0099;PUMH1 Q14671-1;Q14671;Q14671-2 ENST00000257075;ENST00000373741 2 0.74654 1.6625 0.70914 0.96693 1.0579 0.9182 Dak1;Dak2 ATP binding;binding;catalytic activity;cyclase activity;glycerone kinase activity;kinase activity;magnesium ion binding;nucleoside binding;nucleotide binding;purine nucleoside binding;transferase activity alcohol metabolic process;alditol metabolic process;carbohydrate metabolic process;cellular metabolic process;cellular process;glycerol metabolic process;metabolic process;polyol metabolic process;primary metabolic process Glycerolipid metabolism 8 8 8 20.7 20.7 20.7 58.977 8.1193E-208 65206000 34533000 30673000 5134 IPI:IPI00551024.4 Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;Glycerone kinase;FAD-AMP lyase (cyclizing);FAD-AMP lyase (cyclic FMN forming);FMN cyclase DAK Q3LXA3 ENST00000311463;ENST00000394900 K00863 1 0.85788 1.9512 0.94935 1.1271 1.285 1.2396 extracellular region 5 5 5 17.6 17.6 17.6 30.748 3.8531E-63 133760000 70476000 63283000 5136 IPI:IPI00551062.2 Protein canopy homolog 3;Trinucleotide repeat-containing gene 5 protein;CTG repeat protein 4a;Expanded repeat-domain protein CAG/CTG 5 CNPY3;CTG4A;ERDA5;TNRC5;HSPC084;UNQ1934/PRO4409 Q9BT09-1;Q9BT09 ENST00000372836;ENST00000394142 1 0.64962 1.2908 0.67732 0.84622 0.83595 0.89654 DUF1605;HA2;Helicase_C cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;ATP-dependent helicase activity;binding;catalytic activity;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity;RNA helicase activity cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 16 15 15 18.3 17.5 17.5 119.26 1.3961E-194 344630000 182320000 162320000 5137 IPI:IPI00552073.1 Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16;DEAH-box protein 16;ATP-dependent RNA helicase #3 DHX16;DBP2;DDX16;KIAA0577 O60231 ENST00000376442;ENST00000383407 1 0.6748 1.2112 0.66231 0.91582 0.76755 0.88485 DUF2044 10 10 10 19.7 19.7 19.7 72.748 3.9499E-99 152570000 79292000 73280000 5139 IPI:IPI00552546.1;IPI:IPI00478758.2 UPF0557 protein C10orf119 C10orf119 Q9BTE3-2;Q9BTE3;Q9BTE3-1 ENST00000360003 2 0.43874 0.92544 0.47993 0.61566 0.58774 0.6327 Helicase_C;SNF2_N chromosomal part;condensed chromosome kinetochore;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;kinetochore;macromolecular complex;non-membrane-bounded organelle;organelle;organelle part;protein complex ATP binding;binding;catalytic activity;DNA binding;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity cell cycle phase;cell cycle process;cell division;cellular component organization;cellular process;mitosis;nuclear division;organelle fission;organelle organization 12 12 12 13.2 13.2 13.2 141.1 2.9701E-104 70793000 40080000 30713000 5140 IPI:IPI00552569.1 DNA excision repair protein ERCC-6-like;ATP-dependent helicase ERCC6-like;PLK1-interacting checkpoint helicase;Tumor antigen BJ-HCC-15 ERCC6L;PICH Q2NKX8 ENST00000334463 1 0.66729 1.4579 NaN 0.91078 1.0176 NaN CR6_interact cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding cell cycle;cellular process;interspecies interaction between organisms;multi-organism process 4 4 4 23 23 23 25.384 2.2943E-125 8999900 5478900 3521000 5141 IPI:IPI00552587.1 Growth arrest and DNA-damage-inducible proteins-interacting protein 1;CR6-interacting factor 1;CKII beta-associating protein;Papillomavirus L2-interacting nuclear protein 1;p53-responsive gene 6 protein GADD45GIP1;PLINP1;PRG6 Q8TAE8 ENST00000316939 1 0.86619 1.4926 NaN 1.1506 0.95171 NaN Plexin_cytopl;PSI;Sema;TIG cell part;integral to membrane;intracellular;intrinsic to membrane;membrane part molecular transducer activity;receptor activity;semaphorin receptor activity;signal transducer activity;transmembrane receptor activity biological regulation;cell communication;cellular process;developmental process;multicellular organismal development;multicellular organismal process;regulation of biological process;regulation of cellular process;signal transduction Axon guidance 3 3 3 2 2 2 211.08 1.2296E-13 2053300 1156100 897180 5142 IPI:IPI00552671.2 Plexin-A1;Semaphorin receptor NOV PLXNA1;NOV;PLXN1 Q9UIW2 ENST00000393409 K06820 1 NaN 1.1629 NaN NaN 0.70785 NaN 3 3 3 10 10 10 38.808 1.711E-06 540720 159370 381350 5143 IPI:IPI00552849.2;IPI:IPI00827638.1;IPI:IPI00020559.2;IPI:IPI00011374.2;IPI:IPI00178377.2;IPI:IPI00640824.2 Protein FAM76B FAM76B Q5HYJ3-1;Q5HYJ3;Q5HYJ3-2 ENST00000358780;ENST00000398187 6 0.61276 1.2492 0.68265 0.84701 0.81614 0.90639 RNase_PH;RNase_PH_C cytoplasm;exosome (RNase complex);intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;protein complex 3'-5' exonuclease activity;3'-5'-exoribonuclease activity;binding;catalytic activity;exonuclease activity;exoribonuclease activity;hydrolase activity;nuclease activity;nucleic acid binding;protein binding;ribonuclease activity;RNA binding cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 6 6 6 26.1 26.1 26.1 30.039 2.2223E-180 167760000 92808000 74948000 5144 IPI:IPI00552920.2 Exosome complex exonuclease RRP43;Ribosomal RNA-processing protein 43;Exosome component 8;p9;Opa-interacting protein 2 EXOSC8;OIP2;RRP43 Q96B26 ENST00000239893 K01149 1 0.78606 1.5661 0.73352 1.0838 1.0069 0.95936 STAG cell part;cytoskeleton;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle binding;protein binding cell cycle phase;cell cycle process;cell division;cellular component organization;cellular process;chromosome segregation;meiosis;mitosis;nuclear division;organelle fission;organelle organization 18 18 15 16.7 16.7 14.5 141.32 9.2543E-107 138930000 72714000 66213000 5145 IPI:IPI00552978.1;IPI:IPI00018353.2;IPI:IPI00216104.4 Cohesin subunit SA-2;Stromal antigen 2;SCC3 homolog 2 STAG2;SA2 Q8N3U4 ENST00000371144;ENST00000371157;ENST00000371160;ENST00000371166 3 NaN NaN 0.65969 NaN NaN 0.85656 HGTP_anticodon;tRNA-synt_2b cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-oxygen bonds;nucleoside binding;nucleotide binding;proline-tRNA ligase activity;purine nucleoside binding cellular amino acid and derivative metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;prolyl-tRNA aminoacylation;tRNA aminoacylation for protein translation;tRNA metabolic process Aminoacyl-tRNA biosynthesis 2 2 2 4.6 4.6 4.6 53.262 2.0317E-08 2233400 1254400 979030 5146 IPI:IPI00553006.1 Probable prolyl-tRNA synthetase, mitochondrial;Proline--tRNA ligase PARS2 Q7L3T8 ENST00000371279 K01881 1 0.75434 1.6821 0.75623 1.0094 1.0946 1.0662 DUF2450;DUF2451 5 5 5 6.5 6.5 6.5 111.17 7.3359E-55 19241000 10432000 8809100 5147 IPI:IPI00553067.4;IPI:IPI00103148.4 Coiled-coil domain-containing protein 132 CCDC132;KIAA1861 Q96JG6-1;Q96JG6 ENST00000251739;ENST00000305866 2 0.71209 1.5767 0.62418 0.90791 1.0347 0.8272 Epimerase cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;identical protein binding;isomerase activity;protein binding;racemase and epimerase activity;racemase and epimerase activity, acting on carbohydrates and derivatives;UDP-glucose 4-epimerase activity alcohol metabolic process;carbohydrate catabolic process;carbohydrate metabolic process;catabolic process;galactose metabolic process;hexose catabolic process;hexose metabolic process;metabolic process;monosaccharide metabolic process Galactose metabolism;Nucleotide sugars metabolism 4 4 4 11.2 11.2 11.2 38.281 1.383E-11 51943000 26569000 25374000 5148 IPI:IPI00553131.2 UDP-glucose 4-epimerase;UDP-galactose 4-epimerase;Galactowaldenase GALE Q14376 ENST00000313298;ENST00000374497 K01784 1 0.6228 1.7704 0.87943 0.86929 1.1717 1.1629 IATP cell part;cell surface;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle angiostatin binding;ATPase inhibitor activity;binding;calmodulin binding;enzyme binding;enzyme inhibitor activity;enzyme regulator activity;identical protein binding;protein binding;protein dimerization activity;protein homodimerization activity angiogenesis;generation of precursor metabolites and energy;metabolic process;negative regulation of endothelial cell proliferation;protein complex assembly;regulation of endothelial cell proliferation;regulation of nucleotide metabolic process 2 2 2 19.6 19.6 19.6 12.405 0.0022764 220750000 106420000 114330000 5149 IPI:IPI00553153.1 ATPase inhibitor, mitochondrial ATPIF1;ATPI Q9UII2 ENST00000335514 1 0.69456 1.3667 0.72451 0.90133 0.91186 0.915 Ribosomal_S2 cytosolic small ribosomal subunit;intracellular organelle;macromolecular complex;membrane;membrane-bounded organelle;nucleus;organelle;plasma membrane;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit binding;molecular transducer activity;receptor activity;ribonucleoprotein binding;ribosome binding;signal transducer activity;structural constituent of ribosome;structural molecule activity biological adhesion;biosynthetic process;cell adhesion;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome 15 15 15 63.7 63.7 63.7 32.854 0 10945000000 5865700000 5078800000 5150 IPI:IPI00553164.4 40S ribosomal protein SA;Laminin receptor 1;37/67 kDa laminin receptor;Laminin-binding protein precursor p40;37 kDa laminin receptor precursor;67 kDa laminin receptor;Colon carcinoma laminin-binding protein;NEM/1CHD4;Multidrug resistance-associated protein MGr1-Ag RPSA;LAMBR;LAMR1 P08865 ENST00000301821 K02998 1 0.91115 1.7029 0.93961 1.1761 1.1452 1.1848 Cpn60_TCP1 cytoplasm;cytoskeleton;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle;plasma membrane adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 45 45 45 75.8 75.8 75.8 60.533 0 15550000000 7971900000 7578200000 5152 IPI:IPI00553185.2 T-complex protein 1 subunit gamma;CCT-gamma CCT3;CCTG;TRIC5 P49368 ENST00000368261 K09495 1 0.96346 1.7669 0.9814 1.2996 1.139 1.2986 Ferritin cell part;ferritin complex;intracellular ferritin complex;intracellular part;macromolecular complex;protein complex binding;catalytic activity;ferric iron binding;ferroxidase activity;ion binding;iron ion binding;oxidoreductase activity;oxidoreductase activity, oxidizing metal ions;oxidoreductase activity, oxidizing metal ions, oxygen as acceptor;protein binding cation transport;cell proliferation;immune response;immune system process;intracellular sequestering of iron ion;ion transport;iron ion transport;metabolic process;negative regulation of cell proliferation;transition metal ion transport;transport Porphyrin and chlorophyll metabolism 5 5 5 43.2 43.2 43.2 21.225 9.9671E-58 209790000 105250000 104550000 5154 IPI:IPI00554521.2 Ferritin heavy chain;Cell proliferation-inducing gene 15 protein FTH1;FTH;FTHL6;OK/SW-cl.84;PIG15 P02794 ENST00000273550;ENST00000406545 K00522 1 0.59482 1.2801 0.57628 0.80828 0.87389 0.79654 TPP_enzyme_C;TPP_enzyme_M;TPP_enzyme_N cell part;integral to membrane;intrinsic to membrane;membrane part binding;catalytic activity;cation binding;coenzyme binding;cofactor binding;ion binding;magnesium ion binding;metal ion binding;thiamin pyrophosphate binding;transferase activity;vitamin binding 7 7 7 17.1 17.1 17.1 67.867 9.954E-85 109510000 62496000 47009000 5155 IPI:IPI00554541.2;IPI:IPI00556506.3 Acetolactate synthase-like protein;IlvB-like protein ILVBL;AHAS A1L0T0-1;A1L0T0 ENST00000263383;ENST00000269733 K11259 2 NaN 1.5696 NaN NaN 0.99244 NaN cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part 4 4 4 13.8 13.8 13.8 51.588 1.9556E-12 1148500 631210 517250 5156 IPI:IPI00554560.4 Protein C16orf88;Testis-specific gene 118 protein C16orf88;TSG118 Q1ED39 ENST00000219837 1 0.87114 1.865 0.90057 1.1552 1.2863 1.1719 cell fraction;cell part;cytoplasm;intracellular part;soluble fraction binding;enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity;protein binding;protein dimerization activity;protein heterodimerization activity establishment of localization;establishment of protein localization;intracellular protein transport;intracellular transport;protein transport;regulation of catalytic activity;regulation of GTPase activity;regulation of hydrolase activity;transport 8 8 8 6.7 6.7 6.7 155.98 2.2555E-27 45082000 20952000 24130000 5157 IPI:IPI00554590.1;IPI:IPI00477068.1 Rab3 GTPase-activating protein non-catalytic subunit;Rab3 GTPase-activating protein 150 kDa subunit;Rab3-GAP p150;Rab3-GAP regulatory subunit;RGAP-iso RAB3GAP2;KIAA0839 Q9H2M9-1;Q9H2M9 ENST00000237724;ENST00000358951 2 0.77644 1.2335 0.79822 0.93971 0.89598 0.92671 RRM_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;ribonucleoprotein complex binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding cellular biopolymer metabolic process;cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing 5 1 1 23 2.5 2.5 31.232 1.3795E-30 513190000 263190000 250000000 5158 IPI:IPI00554613.1;IPI:IPI00479814.1 Heterogeneous nuclear ribonucleoprotein L-like;Stromal RNA-regulating factor HNRPLL;SRRF;BLOCK24 Q8WVV9-2;Q8WVV9;Q8WVV9-3 ENST00000272249;ENST00000358367;ENST00000378908 2 1.0583 1.7815 1.0533 1.2565 1.2739 1.2513 Pro-kuma_activ cell fraction;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;intracellular organelle;lysosome;lytic vacuole;melanosome;membrane-bounded organelle;membrane-bounded vesicle;mitochondrion;organelle;soluble fraction;vacuole;vesicle binding;catalytic activity;endopeptidase activity;exopeptidase activity;hydrolase activity;peptidase activity;protein binding;serine hydrolase activity;serine-type endopeptidase activity;serine-type peptidase activity;tripeptidyl-peptidase activity catabolic process;lipid metabolic process;lysosome organization;metabolic process;nervous system development;organelle organization;peptide metabolic process;proteolysis;system process;tissue homeostasis;vacuole organization 2 2 2 5 5 5 61.247 7.3914E-95 243120000 120230000 122890000 5159 IPI:IPI00939667.1;IPI:IPI00554617.2 Tripeptidyl-peptidase 1;Tripeptidyl-peptidase I;Tripeptidyl aminopeptidase;Lysosomal pepstatin-insensitive protease;Cell growth-inhibiting gene 1 protein TPP1;CLN2;GIG1;UNQ267/PRO304 O14773-1;O14773;O14773-2 ENST00000299427 K01279 2 0.75221 1.4596 0.74711 0.94856 1.0084 0.98365 Peptidase_C54 cell part;cytoplasm;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;microtubule associated complex;organelle part;protein complex binding;catalytic activity;cysteine-type peptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides;protein binding autophagy;catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;protein transport;proteolysis;transport Regulation of autophagy 11 11 11 31.6 31.6 31.6 52.544 0 127070000 70714000 56357000 5160 IPI:IPI00746254.1;IPI:IPI00554649.1;IPI:IPI00647200.2;IPI:IPI00941681.1;IPI:IPI00743619.2;IPI:IPI00292327.1;IPI:IPI00064708.3 Cysteine protease ATG4B;Autophagy-related protein 4 homolog B;Autophagin-1;Autophagy-related cysteine endopeptidase 1;AUT-like 1 cysteine endopeptidase ATG4B;APG4B;AUTL1;KIAA0943 Q9Y4P1-2;Q9Y4P1;Q9Y4P1-1;Q9Y4P1-6;Q9Y4P1-4;Q9Y4P1-3 ENST00000311517;ENST00000344376;ENST00000396411;ENST00000400771;ENST00000400772;ENST00000404914;ENST00000405546 K08342 7 0.7458 1.6154 0.88183 0.97041 1.0835 1.1301 ETC_C1_NDUFA5 cytoplasmic part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;mitochondrial membrane part;mitochondrial part;mitochondrial respiratory chain complex I;NADH dehydrogenase complex;organelle part;protein complex catalytic activity;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor cellular metabolic process;cellular process;electron transport chain;generation of precursor metabolites and energy;metabolic process;mitochondrial electron transport, NADH to ubiquinone;respiratory electron transport chain;transport Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 6 6 6 59.5 59.5 59.5 13.459 4.4346E-304 176890000 93758000 83127000 5161 IPI:IPI00554681.2 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5;NADH-ubiquinone oxidoreductase 13 kDa-B subunit;Complex I-13kD-B;Complex I subunit B13 NDUFA5 Q16718 ENST00000340034;ENST00000355749 K03949 1 0.24989 7.178 0.21858 0.33714 4.9417 0.29469 Arm;HEAT anchoring junction;cell fraction;cell junction;cell part;cell-cell junction;desmosome;insoluble fraction;membrane fraction;membrane part;plasma membrane part;soluble fraction binding;cytoskeletal protein binding;enzyme binding;phosphatase binding;protein binding;protein phosphatase binding Acute myeloid leukemia;Pathways in cancer + 13 13 13 21.7 21.7 21.7 81.744 1.7879E-98 413890000 73473000 340410000 5162 IPI:IPI00554711.3;IPI:IPI00017292.1 Junction plakoglobin;Desmoplakin-3;Desmoplakin III;Catenin gamma JUP;CTNNG;DP3 P14923 ENST00000310706;ENST00000393930;ENST00000393931 K10056 2 0.80043 1.301 0.74076 0.98334 0.88822 0.95453 Ribosomal_L16 cytosolic large ribosomal subunit;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;large ribosomal subunit;macromolecular complex;membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosomal subunit structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation 17 17 17 55.1 55.1 55.1 24.604 7.2968E-216 4077500000 2121800000 1955700000 5163 IPI:IPI00554723.5;IPI:IPI00064765.3 60S ribosomal protein L10;Protein QM;Tumor suppressor QM;Laminin receptor homolog RPL10;DXS648E;QM P27635 ENST00000344746;ENST00000369810;ENST00000369817;ENST00000406022 2 0.81905 1.5344 0.84889 1.0704 1.0194 1.0831 HEAT cell fraction;cytoskeleton;cytosol;macromolecular complex;membrane;membrane-bounded organelle;microtubule cytoskeleton;mitochondrion;nucleus;organelle;protein phosphatase type 2A complex;protein serine/threonine phosphatase complex;soluble fraction antigen binding;binding;enzyme regulator activity;phosphatase regulator activity;protein binding;protein dimerization activity;protein heterodimerization activity;protein phosphatase regulator activity;protein phosphatase type 2A regulator activity inactivation of MAPK activity;negative regulation of protein amino acid phosphorylation;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of cell growth;regulation of protein amino acid phosphorylation Long-term depression;TGF-beta signaling pathway;Tight junction;Wnt signaling pathway 29 29 23 58.2 58.2 44 65.308 0 3837600000 1965200000 1872400000 5164 IPI:IPI00554737.3 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;PP2A, subunit A, PR65-alpha isoform;PP2A, subunit A, R1-alpha isoform;Medium tumor antigen-associated 61 kDa protein PPP2R1A P30153 ENST00000322088 K03456 1 0.84251 1.7642 0.88882 1.1221 1.1733 1.1457 API5 cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;fibroblast growth factor binding;growth factor binding;protein binding anti-apoptosis;apoptosis;cell death;cellular process;death;negative regulation of apoptosis;negative regulation of programmed cell death;programmed cell death;regulation of apoptosis;regulation of cell death;regulation of programmed cell death 17 17 17 34.9 34.9 34.9 56.769 1.2626E-177 790930000 425300000 365640000 5165 IPI:IPI00554742.3;IPI:IPI00855856.2;IPI:IPI00555572.1;IPI:IPI00555743.1 Apoptosis inhibitor 5;Fibroblast growth factor 2-interacting factor;Protein XAGL;Antiapoptosis clone 11 protein;Cell migration-inducing gene 8 protein API5;MIG8 Q9BZZ5-2;Q9BZZ5;Q9BZZ5-4;Q9BZZ5-1;Q9BZZ5-3 ENST00000378852 4 0.92739 1.6454 NaN 1.1661 1.0932 NaN cNMP_binding;RIIa cAMP-dependent protein kinase complex;centrosome;Golgi apparatus;intracellular organelle;macromolecular complex;membrane-bounded organelle;microtubule organizing center;mitochondrion;non-membrane-bounded organelle;organelle AMP binding;binding;cAMP-dependent protein kinase regulator activity;enzyme regulator activity;kinase regulator activity;nucleoside binding;nucleotide binding;protein kinase regulator activity;purine nucleoside binding;purine nucleotide binding cell communication;cellular process;hormone-mediated signaling;intracellular signaling cascade;regulation of protein amino acid phosphorylation;response to endogenous stimulus;response to hormone stimulus;response to organic substance;signal transduction Apoptosis;Insulin signaling pathway 7 3 3 20.8 11 11 46.302 3.4601E-103 3838800 2172100 1666700 5166 IPI:IPI00554752.3 cAMP-dependent protein kinase type II-beta regulatory subunit PRKAR2B P31323 ENST00000265717 K04739 1 0.58781 1.8432 NaN 0.87208 1.0107 NaN HMG14_17 cell part;chromatin;chromosomal part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;nucleus;organelle;organelle part binding;DNA binding;nucleic acid binding;positive transcription elongation factor activity;RNA polymerase II transcription factor activity;transcription elongation regulator activity;transcription regulator activity 3 3 3 37 37 37 10.659 7.4712E-08 28085000 16580000 11505000 5167 IPI:IPI00554761.2 Non-histone chromosomal protein HMG-14;High-mobility group nucleosome-binding domain-containing protein 1 HMGN1;HMG14 P05114 ENST00000288344;ENST00000380749 K11299 1 0.63162 1.1365 0.61435 0.85318 0.78533 0.81207 Asn_synthase;GATase_2 cell fraction;cell part;cytoplasmic part;cytosol;intracellular part;soluble fraction asparagine synthase (glutamine-hydrolyzing) activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleoside binding;nucleotide binding;purine nucleoside binding asparagine biosynthetic process;asparagine metabolic process;cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;glutamine metabolic process;nitrogen compound metabolic process;organic acid metabolic process Alanine and aspartate metabolism;Nitrogen metabolism 22 22 22 44 44 44 64.369 0 1130400000 623980000 506420000 5168 IPI:IPI00554777.2 Asparagine synthetase [glutamine-hydrolyzing];Glutamine-dependent asparagine synthetase;Cell cycle control protein TS11 ASNS;TS11 P08243 ENST00000175506;ENST00000394308;ENST00000394309 K01953 1 0.81025 1.4234 0.77283 1.045 0.97705 1.0098 Glutaredoxin;Pyr_redox;Pyr_redox_2;Pyr_redox_dim cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;disulfide oxidoreductase activity;electron carrier activity;nucleoside binding;nucleotide binding;protein disulfide oxidoreductase activity;purine nucleoside binding;selenium binding;thioredoxin-disulfide reductase activity cell communication;cell redox homeostasis;cellular homeostasis;cellular metabolic process;cellular process;electron transport chain;generation of precursor metabolites and energy;homeostatic process;metabolic process;signal transduction;transport Pyrimidine metabolism 21 21 21 41.2 41.2 41.2 71.152 0 1699500000 912050000 787450000 5169 IPI:IPI00884896.2;IPI:IPI00885213.1;IPI:IPI00783641.4;IPI:IPI00847482.5;IPI:IPI00871867.2;IPI:IPI00554786.5;IPI:IPI00220566.2;IPI:IPI00157820.3;IPI:IPI00883598.3 Thioredoxin reductase 1, cytoplasmic;Thioredoxin reductase TR1;KM-102-derived reductase-like factor;Gene associated with retinoid-IFN-induced mortality 12 protein TXNRD1;KDRF Q16881-1;Q16881;Q16881-6;Q16881-3;Q16881-4;Q16881-2;Q16881-5 ENST00000354940;ENST00000378070 K00384 9 1.0681 1.8591 1.037 1.3368 1.2975 1.2669 ARPC4 Arp2/3 protein complex;cell part;cell projection;cytoplasm;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;organelle part;protein complex actin binding;binding;cytoskeletal protein binding;protein binding actin filament organization;actin polymerization or depolymerization;anatomical structure formation;cellular component assembly;cellular component organization;cellular process;cytoskeleton organization;organelle organization;protein complex assembly 9 9 9 45.2 45.2 45.2 19.667 1.6501E-166 1039100000 528390000 510750000 5170 IPI:IPI00554811.2 Actin-related protein 2/3 complex subunit 4;Arp2/3 complex 20 kDa subunit ARPC4;ARC20 P59998 ENST00000287613;ENST00000336674;ENST00000397261 1 1.9089 3.0285 1.8864 2.4891 2.0572 2.486 HATPase_c;HSP90 adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process;response to stress 10 1 1 11.9 2.2 2.2 58.264 7.6684E-131 169640000 75503000 94136000 5171 IPI:IPI00555565.1 Putative heat shock protein HSP 90-beta 4 HSP90AB4P Q58FF6 ENST00000380522 1 0.77372 1.4852 0.81345 1.0162 0.95962 1.0476 Asparaginase_2 cell part;cytoplasm;intracellular part asparaginase activity;catalytic activity;hydrolase activity;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity asparagine catabolic process;asparagine metabolic process;catabolic process;cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;metabolic process;nitrogen compound metabolic process;organic acid metabolic process Alanine and aspartate metabolism;Cyanoamino acid metabolism;Nitrogen metabolism 7 7 7 36 36 36 32.054 0 190990000 103540000 87444000 5172 IPI:IPI00555734.3;IPI:IPI00867663.1 L-asparaginase;L-asparagine amidohydrolase;Asparaginase-like protein 1 ASRGL1;ALP;CRASH Q7L266-1;Q7L266;Q7L266-2 ENST00000301776 K01424 2 0.7354 1.33 0.74446 0.93415 0.91879 0.90782 Ribosomal_L14e cell part;cytoplasmic part;cytosolic large ribosomal subunit;cytosolic part;intracellular organelle part;intracellular part;large ribosomal subunit;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit binding;nucleic acid binding;protein binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA processing;rRNA processing;translational elongation Ribosome 8 8 8 36.4 36.4 36.4 23.787 4.4842E-119 3817900000 2044400000 1773500000 5173 IPI:IPI00555744.6 60S ribosomal protein L14;CAG-ISL 7 RPL14 P50914 ENST00000338970;ENST00000396203 K02875 1 0.92112 1.9626 0.94661 1.2422 1.341 1.2503 RRM_1 cell part;cytoplasmic part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;nucleotide binding;RNA binding biosynthetic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription 15 15 15 26.3 26.3 26.3 64.179 3.5513E-92 222580000 117640000 104940000 5174 IPI:IPI00555833.1;IPI:IPI00386418.4;IPI:IPI00555987.4;IPI:IPI00292940.2 Myelin expression factor 2;MST156 MYEF2;KIAA1341 Q9P2K5-1;Q9P2K5;Q9P2K5-2;Q9P2K5-3 ENST00000267836;ENST00000324324;ENST00000396590 4 0.77371 1.7983 0.86415 1.0219 1.1124 1.1344 OCIA cell part;cytoplasmic part;endosome;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle 10 10 10 51.3 51.3 51.3 16.953 2.2767E-97 572300000 305170000 267130000 5176 IPI:IPI00555902.1;IPI:IPI00181546.4 OCIA domain-containing protein 2;Ovarian carcinoma immunoreactive antigen-like protein OCIAD2 Q56VL3-1;Q56VL3;Q56VL3-2 ENST00000273860;ENST00000381464 2 0.90324 1.7332 0.9112 1.1159 1.1325 1.1772 Proteasome centrosome;cytosol;intracellular membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;microtubule organizing center;non-membrane-bounded organelle;nucleus;organelle;proteasome core complex catalytic activity;endopeptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides;threonine-type endopeptidase activity;threonine-type peptidase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Proteasome 9 9 9 50 50 50 29.204 0 1172900000 620320000 552590000 5177 IPI:IPI00555956.2 Proteasome subunit beta type-4;Macropain beta chain;Multicatalytic endopeptidase complex beta chain;Proteasome chain 3;HSN3;HsBPROS26 PSMB4 P28070 ENST00000290541 K02736 1 0.80552 1.343 0.52426 1.0311 0.93725 0.71677 cell division site part;cell fraction;contractile ring;insoluble fraction;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane fraction;non-membrane-bounded organelle;nuclear matrix;organelle;spindle actin binding;binding;cytoskeletal protein binding;protein binding biological adhesion;cell adhesion;cell cycle;cellular process;developmental maturation;developmental process;negative regulation of myeloid cell apoptosis;regulation of cell death;regulation of mitotic cell cycle;regulation of myeloid cell apoptosis 5 5 5 9.8 9.8 9.8 45.287 2.4411E-17 18840000 10756000 8084400 5179 IPI:IPI00607605.4;IPI:IPI00556323.2;IPI:IPI00845303.2;IPI:IPI00419963.4;IPI:IPI00845323.1 Macrophage erythroblast attacher;Erythroblast macrophage protein;Cell proliferation-inducing gene 5 protein;Human lung cancer oncogene 10 protein MAEA;EMP;HLC10;PIG5 Q7L5Y9-1;Q7L5Y9;Q7L5Y9-3;Q7L5Y9-2 ENST00000264750;ENST00000303400;ENST00000382947 5 0.88701 1.718 0.91531 1.1512 1.1751 1.1649 tRNA-synt_1e cell part;cytoplasm;intracellular part aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;cysteine-tRNA ligase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;RNA binding;tRNA binding;zinc ion binding cellular amino acid and derivative metabolic process;cysteinyl-tRNA aminoacylation;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;tRNA aminoacylation for protein translation;tRNA metabolic process 28 28 28 40.5 40.5 40.5 85.472 3.342E-179 1736900000 879420000 857430000 5180 IPI:IPI00556365.1;IPI:IPI00939491.1 Cysteinyl-tRNA synthetase, cytoplasmic;Cysteine--tRNA ligase CARS P49589-1;P49589;P49589-2 ENST00000278224;ENST00000380525 2 0.79581 1.75 NaN 1.0872 1.1286 NaN VDRIP cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;mediator complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;protein binding;receptor activity;receptor binding;RNA polymerase II transcription factor activity;signal transducer activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding cell communication;intracellular signaling cascade;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;signal transduction;transcription initiation;transcription initiation from RNA polymerase II promoter 4 4 4 18.9 18.9 18.9 29.745 1.4271E-23 22908000 11791000 11117000 5181 IPI:IPI00556494.3 Mediator of RNA polymerase II transcription subunit 4;Mediator complex subunit 4;Vitamin D3 receptor-interacting protein complex 36 kDa component;Activator-recruited cofactor 36 kDa component;TRAP/SMCC/PC2 subunit p36 subunit MED4;ARC36;DRIP36;VDRIP;HSPC126 Q9NPJ6 ENST00000258648 1 0.58633 1.2467 0.73539 0.85841 0.81965 1.0179 PSP;zf-CCHC cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;cation binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transition metal ion binding;zinc ion binding cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 8 8 8 14.6 14.6 14.6 78.576 4.2953E-126 78522000 42558000 35964000 5182 IPI:IPI00556594.3;IPI:IPI00166422.6 Zinc finger CCHC domain-containing protein 8 ZCCHC8 Q6NZY4-1;Q6NZY4;Q6NZY4-2 ENST00000336229 2 0.89519 1.1678 0.84236 1.2046 0.84545 1.051 FHA;Fork_head cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;transcription factor activity;transcription regulator activity biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;muscle organ development;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription 7 7 6 11.7 11.7 10.1 75.456 5.3872E-133 84586000 42511000 42075000 5183 IPI:IPI00556645.3;IPI:IPI00807514.1 Forkhead box protein K1;Myocyte nuclear factor FOXK1;MNF P85037-1;P85037;P85037-2 ENST00000328914 K09404 2 0.75625 1.3746 0.74396 0.98625 0.90712 0.99637 HECT;IQ cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;protein complex acid-amino acid ligase activity;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;protein binding;small conjugating protein ligase activity;ubiquitin-protein ligase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein metabolic process;protein modification process;protein polyubiquitination;protein ubiquitination;proteolysis Ubiquitin mediated proteolysis 7 7 7 7.4 7.4 7.4 123.92 9.0906E-65 60185000 32226000 27959000 5184 IPI:IPI00604464.3;IPI:IPI00472810.3;IPI:IPI00411748.3 Ubiquitin-protein ligase E3C UBE3C;KIAA0010 Q15386-1;Q15386;Q15386-2 ENST00000348165;ENST00000389103 K10589 3 0.81949 1.3909 0.82756 1.0189 0.93657 1.0274 HGTP_anticodon;TGS;tRNA_SAD;tRNA-synt_2b cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-oxygen bonds;nucleoside binding;nucleotide binding;purine nucleoside binding;threonine-tRNA ligase activity cellular amino acid and derivative metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;threonyl-tRNA aminoacylation;tRNA aminoacylation for protein translation;tRNA metabolic process Aminoacyl-tRNA biosynthesis;Glycine, serine and threonine metabolism 8 8 8 12.5 12.5 12.5 81.035 1.4692E-106 36168000 19683000 16484000 5185 IPI:IPI00604527.2 Threonyl-tRNA synthetase, mitochondrial;Threonine--tRNA ligase;Threonyl-tRNA synthetase-like 1 TARS2;TARSL1 Q9BW92 ENST00000369064 K01868 1 0.4451 0.87104 NaN 0.58663 0.58502 NaN zf-4CXXC_R1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 4 3 3 12.7 10.7 10.7 51.444 4.2445E-14 28751000 15841000 12910000 5186 IPI:IPI00784714.1;IPI:IPI00604551.3;IPI:IPI00785043.1 Cell division cycle-associated protein 7;Protein JPO1 CDCA7;JPO1 Q9BWT1-2;Q9BWT1;Q9BWT1-1;Q9BWT1-3 ENST00000306721;ENST00000347703;ENST00000392567 3 0.64759 1.2458 0.61396 0.87354 0.79876 0.79355 EMP24_GP25L ER-Golgi intermediate compartment membrane;Golgi apparatus;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intrinsic to membrane;membrane;membrane-bounded organelle;organelle;organelle membrane;organelle part establishment of localization;establishment of protein localization;protein transport;transport 3 3 3 18.9 18.9 18.9 24.777 4.451E-09 103810000 57730000 46077000 5187 IPI:IPI00604599.2 Transmembrane emp24 domain-containing protein 3;Membrane protein p24B TMED3;C15orf22;UNQ5357/PRO1078 Q9Y3Q3 ENST00000299705 1 0.64295 1.384 0.69091 0.87152 0.87124 0.92322 FYDLN_acid;RRM_1 cell cortex;cytoplasmic part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;ribonucleoprotein complex binding;DNA binding;nucleic acid binding;nucleotide binding;protein binding;protein C-terminus binding;RNA binding;sequence-specific DNA binding;telomeric DNA binding anatomical structure formation;anatomical structure formation involved in morphogenesis;angiogenesis;developmental process 38 38 38 37.7 37.7 37.7 76.613 0 17400000000 9409400000 7990700000 5188 IPI:IPI00604620.3 Nucleolin;Protein C23 NCL P19338 ENST00000322723;ENST00000356936 K11294 1 0.83879 1.2841 0.77748 1.0502 0.90599 0.95394 NIF3 cell part;cytoplasm;intracellular part binding;protein binding;transcription factor binding positive regulation of biosynthetic process;positive regulation of metabolic process;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of transcription, DNA-dependent 6 6 6 21.8 21.8 21.8 41.968 1.8884E-49 34937000 18695000 16241000 5189 IPI:IPI00604624.1;IPI:IPI00873590.1 NIF3-like protein 1;Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 1 protein NIF3L1;ALS2CR1;MDS015;My018 Q9GZT8-1;Q9GZT8;Q9GZT8-2 ENST00000359683;ENST00000403702;ENST00000409020;ENST00000409357 2 0.56166 1.1471 0.64558 0.74375 0.72603 0.94975 DUF1162 cell part;intracellular binding;protein binding cellular process;endosome transport;establishment of protein localization;Golgi to endosome transport;Golgi vesicle transport;intracellular transport;post-Golgi vesicle-mediated transport;protein transport;transport;vesicle-mediated transport 12 12 12 4.8 4.8 4.8 347.67 1.6274E-49 34354000 19814000 14540000 5190 IPI:IPI00604660.4;IPI:IPI00843835.1;IPI:IPI00746613.2;IPI:IPI00478586.3 Vacuolar protein sorting-associated protein 13A;Chorein;Chorea-acanthocytosis protein VPS13A;CHAC;KIAA0986 Q96RL7-4;Q96RL7;Q96RL7-1;Q96RL7-3;Q96RL7-2 ENST00000355766;ENST00000360280;ENST00000376634;ENST00000376636;ENST00000376646 4 NaN 1.5164 NaN NaN 0.95986 NaN FHA;Kinesin;PH cell part;cytoplasmic part;cytoskeletal part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;microtubule;nucleus;organelle;organelle part ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;microtubule motor activity;motor activity;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity anterograde axon cargo transport;axon cargo transport;cellular process;cytoskeleton-dependent intracellular transport;intracellular transport;microtubule-based movement;microtubule-based process;microtubule-based transport;transport 3 1 1 1.9 0.8 0.8 202.9 4.094E-05 6986600 3604500 3382100 5191 IPI:IPI00815672.3;IPI:IPI00604711.3 Kinesin-like protein KIF1A;Axonal transporter of synaptic vesicles;Microtubule-based motor KIF1A;Unc-104- and KIF1A-related protein KIF1A;ATSV;C2orf20 Q12756-2;Q12756;Q12756-1 ENST00000373308;ENST00000404283 K10392 2 0.93661 1.6488 0.88852 1.2798 1.0632 1.1822 Pkinase cell cortex;cell part;cell projection;cytoplasmic part;endomembrane system;intracellular part;lamellipodium;membrane ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups cellular process;ER to Golgi vesicle-mediated transport;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein modification process;transport;vesicle-mediated transport 4 4 4 10.5 10.5 10.5 59.844 4.1235E-94 123670000 62963000 60708000 5192 IPI:IPI00604756.2 Nuclear receptor-binding protein NRBP1;BCON3;NRBP Q9UHY1 ENST00000233557;ENST00000379852;ENST00000379863 K08875 1 0.66287 1.4674 0.6914 0.8904 1.0048 0.94052 DPPIV_N;Peptidase_S9 cell part;cytoplasmic part;cytosol;intracellular part;membrane aminopeptidase activity;catalytic activity;exopeptidase activity;hydrolase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides;serine hydrolase activity;serine-type peptidase activity biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis 7 7 7 8.4 8.4 8.4 110.24 1.1166E-43 66494000 38807000 27687000 5193 IPI:IPI00940180.1;IPI:IPI00604777.5;IPI:IPI00604483.1;IPI:IPI00604694.1;IPI:IPI00604645.1 Dipeptidyl peptidase 9;Dipeptidyl peptidase IX;DP9;Dipeptidyl peptidase-like protein 9;Dipeptidyl peptidase IV-related protein 2 DPP9;DPRP2 Q86TI2-2;Q86TI2;Q86TI2-1;Q86TI2-4;Q86TI2-3;Q86TI2-5 ENST00000357909;ENST00000381797 5 0.46533 0.71047 NaN 0.557 0.4883 NaN Tis11B_N;zf-CCCH cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;RNA binding;transcription factor activity;transcription regulator activity;transition metal ion binding;zinc ion binding cell proliferation;cellular process 3 3 3 10.9 10.9 10.9 51.447 1.3757E-20 1430900 979270 451640 5194 IPI:IPI00604786.2 Butyrate response factor 2;Protein TIS11D;EGF-response factor 2 ZFP36L2;BRF2;ERF2;RNF162C;TIS11D P47974 ENST00000282388 1 1.2332 2.2123 1.1413 1.6242 1.483 1.5119 UCH catalytic activity;cysteine-type peptidase activity;hydrolase activity;hydrolase activity, acting on ester bonds;peptidase activity;peptidase activity, acting on L-amino acid peptides;thiolester hydrolase activity;ubiquitin thiolesterase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process 20 20 20 18 18 18 157.27 3.0246E-282 285710000 148290000 137410000 5195 IPI:IPI00607554.1;IPI:IPI00165528.1;IPI:IPI00607731.1 Ubiquitin carboxyl-terminal hydrolase 47;Ubiquitin thioesterase 47;Ubiquitin-specific-processing protease 47;Deubiquitinating enzyme 47 USP47 Q96K76-1;Q96K76;Q96K76-2 ENST00000305481;ENST00000339865;ENST00000399455 K11857 3 0.80708 1.537 0.82745 1.0368 1.0161 1.0516 Arm binding;enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity 26 26 26 48.8 48.8 48.8 66.316 0 2331900000 1208800000 1123100000 5196 IPI:IPI00607591.3;IPI:IPI00856100.1 Rap1 GTPase-GDP dissociation stimulator 1;SMG GDS protein;SMG P21 stimulatory GDP/GTP exchange protein;Exchange factor smgGDS RAP1GDS1 P52306-1;P52306;P52306-2 ENST00000339360;ENST00000408900;ENST00000408927 2 0.70104 1.3391 0.92674 0.9265 0.84166 1.2553 MRP-L51 cytoplasmic part;intracellular part;large ribosomal subunit;macromolecular complex;mitochondrial large ribosomal subunit;mitochondrial part;organellar large ribosomal subunit;organelle part;ribonucleoprotein complex;ribosomal subunit structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 4 4 4 27.3 27.3 27.3 15.095 1.8026E-57 43691000 23652000 20039000 5197 IPI:IPI00607627.3 39S ribosomal protein L51, mitochondrial;bMRP-64 MRPL51;MRP64;CDA09;HSPC241 Q4U2R6 ENST00000229238 1 0.85861 1.3732 NaN 1.1188 0.83207 NaN Sds3 cell part;chromatin remodeling complex;histone deacetylase complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;Sin3 complex;Sin3-type complex binding;enzyme binding;histone deacetylase binding;protein binding biosynthetic process;chromatin organization;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;regulation of transcription, DNA-dependent;transcription 3 3 3 9.5 9.5 9.5 38.136 2.9527E-54 1641100 866920 774220 5198 IPI:IPI00607645.5 Sin3 histone deacetylase corepressor complex component SDS3;Suppressor of defective silencing 3 protein homolog;45 kDa Sin3-associated polypeptide SUDS3;SAP45;SDS3 Q9H7L9 ENST00000251152 1 1.119 2.2391 0.97448 1.5485 1.3885 1.4396 NUDIX cell part;cytoplasm;intracellular part binding;catalytic activity;diphosphoinositol-polyphosphate diphosphatase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;magnesium ion binding;pyrophosphatase activity cell communication;intracellular signaling cascade;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;signal transduction;transport 4 4 4 27.8 27.8 27.8 20.306 1.7928E-15 27563000 14866000 12697000 5199 IPI:IPI00607685.1;IPI:IPI00021408.1;IPI:IPI00305384.3;IPI:IPI00549204.1;IPI:IPI00396090.3 Diphosphoinositol polyphosphate phosphohydrolase 2;Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2;Nucleoside diphosphate-linked moiety X motif 4;Diphosphoinositol polyphosphate phosphohydrolase 3-beta;Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-beta;Nucleoside diphosphate-linked moiety X motif 11;Diphosphoinositol polyphosphate phosphohydrolase 3-alpha;Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-alpha;Nucleoside diphosphate-linked moiety X motif 10 NUDT4;DIPP2;KIAA0487;HDCMB47P;NUDT11;APS1;DIPP3B;NUDT10;APS2;DIPP3A Q9NZJ9-1;Q9NZJ9;Q9NZJ9-2;Q96G61;Q8NFP7;Q9NZJ9-3 ENST00000337179;ENST00000360993;ENST00000375992;ENST00000356450;ENST00000376006 K07766 5 0.75154 1.3791 0.76108 0.98785 0.89813 0.99732 Mtc cell part;cytoplasmic part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;mitochondrial membrane;mitochondrial part;organelle membrane;organelle part binding;cation transmembrane transporter activity;ion transmembrane transporter activity;iron ion binding;substrate-specific transmembrane transporter activity;substrate-specific transporter activity;transmembrane transporter activity;transporter activity cation transport;di-, tri-valent inorganic cation transport;establishment of localization;ion transport;iron ion transport;metal ion transport;transition metal ion transport;transport 3 1 1 16.3 5.9 5.9 24.587 6.9999E-06 27706000 15322000 12384000 5200 IPI:IPI00607781.1 Sideroflexin-4;Breast cancer resistance marker 1 SFXN4;BCRM1 Q6P4A7-3;Q6P4A7 ENST00000330036;ENST00000355697 1 0.95042 1.7351 0.87442 1.2355 1.205 1.13 adh_short cell part;cytoplasm;intracellular part 3-hydroxybutyrate dehydrogenase activity;binding;catalytic activity;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor catabolic process;cellular process;fatty acid beta-oxidation;fatty acid catabolic process;fatty acid metabolic process;lipid catabolic process;lipid metabolic process;metabolic process;organic acid catabolic process;organic acid metabolic process Butanoate metabolism;Synthesis and degradation of ketone bodies 7 7 7 31.8 31.8 31.8 26.724 1.0539E-138 119080000 64781000 54298000 5201 IPI:IPI00607799.5;IPI:IPI00446769.4 3-hydroxybutyrate dehydrogenase type 2;R-beta-hydroxybutyrate dehydrogenase;Dehydrogenase/reductase SDR family member 6;Oxidoreductase UCPA BDH2;DHRS6;UNQ6308/PRO20933 Q9BUT1-1;Q9BUT1;Q9BUT1-2 ENST00000296424 K00019 2 0.83566 1.5997 0.87588 1.0708 1.1012 1.1174 G6PD_C;G6PD_N;Glucosamine_iso endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;membrane-enclosed lumen;organelle;organelle lumen;organelle part binding;carboxylesterase activity;catalytic activity;glucose-6-phosphate dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors metabolic process;oxidation reduction Pentose phosphate pathway 6 6 6 10.4 10.4 10.4 88.892 2.8174E-106 33595000 17522000 16074000 5202 IPI:IPI00607861.2 GDH/6PGL endoplasmic bifunctional protein;Glucose 1-dehydrogenase;Hexose-6-phosphate dehydrogenase;6-phosphogluconolactonase H6PD;GDH O95479 ENST00000377403 K00034;K01057 1 0.42162 1.252 NaN 0.5986 0.78066 NaN PHD;SPOC;TFIIS_M cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding apoptosis;biosynthetic process;cell death;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;programmed cell death;transcription 10 10 10 5.2 5.2 5.2 243.87 1.6084E-47 30117000 16217000 13900000 5203 IPI:IPI00619921.3;IPI:IPI00249982.4;IPI:IPI00183350.1;IPI:IPI00249984.2 Death-inducer obliterator 1;Death-associated transcription factor 1 DIDO1;C20orf158;DATF1;KIAA0333 Q9BTC0-4;Q9BTC0;Q9BTC0-1 ENST00000266070;ENST00000266071;ENST00000354665;ENST00000370371;ENST00000395343 4 NaN 1.0227 NaN NaN 0.7188 NaN Kelch_1;Kelch_2 cell part;cytoplasmic part;endosomal part;endosome membrane;intracellular organelle part;intracellular part;membrane;organelle membrane;organelle part cellular component organization;cellular process;endocytosis;membrane docking;membrane invagination;membrane organization;receptor-mediated endocytosis;transport;vesicle docking;vesicle docking during exocytosis;vesicle-mediated transport 3 3 3 8.3 8.3 8.3 40.564 2.1399E-16 4311500 2391500 1920000 5204 IPI:IPI00639811.2;IPI:IPI00384623.2 Rab9 effector protein with Kelch motifs;40 kDa Rab9 effector protein;p40 RABEPK;RAB9P40 Q7Z6M1-1;Q7Z6M1 ENST00000259460;ENST00000373538;ENST00000394125 2 0.47948 1.0941 0.53412 0.66023 0.69942 0.65428 3 3 3 13.4 13.4 13.4 29.107 1.5391E-09 12736000 6988100 5747800 5205 IPI:IPI00639887.3;IPI:IPI00607866.1 Protein FAM60A;Tera protein homolog FAM60A;C12orf14;L4 Q9NP50-1;Q9NP50 ENST00000337682;ENST00000395766 2 0.90682 1.9087 0.92461 1.2406 1.1777 1.2464 CAP_C;CAP_N cell part;membrane;plasma membrane actin binding;binding;cytoskeletal protein binding;protein binding activation of adenylate cyclase activity;cell communication;cellular process;establishment or maintenance of cell polarity;regulation of biosynthetic process;regulation of nucleotide metabolic process;signal transduction 31 31 1 54.6 54.6 4.6 51.784 0 3838400000 2000300000 1838100000 5206 IPI:IPI00639931.2 Adenylyl cyclase-associated protein 1 CAP1;CAP Q01518-2;Q01518 ENST00000340450;ENST00000372792;ENST00000372805 1 0.90716 1.6141 0.88935 1.1884 1.0397 1.0835 ArfGap;PH;RA;RhoGAP;SAM_1 cell part;cytoplasmic part;Golgi apparatus part;Golgi cisterna membrane;Golgi membrane;intracellular organelle part;intracellular part;membrane;organelle membrane;organelle part;plasma membrane binding;enzyme activator activity;GTPase activator activity;phosphatidylinositol-3,4,5-trisphosphate binding;phospholipid binding;protein binding;Ras GTPase activator activity;Rho GTPase activator activity;small GTPase regulator activity actin filament organization;cell communication;cell cycle process;cellular component organization;cellular process;cytoskeleton organization;negative regulation of organelle organization;organelle organization;regulation of cell shape;signal transduction 12 12 12 10.6 10.6 10.6 162.19 4.7616E-63 25205000 14851000 10354000 5207 IPI:IPI00828080.1;IPI:IPI00639996.3;IPI:IPI00479190.3;IPI:IPI00646915.2;IPI:IPI00220421.2;IPI:IPI00640351.2;IPI:IPI00514588.1;IPI:IPI00100939.1 Arf-GAP, Rho-GAP domain, ANK repeat and PH domain-containing protein 1;Centaurin-delta-2 ARAP1;CENTD2;KIAA0782 Q96P48-6;Q96P48;Q96P48-3;Q96P48-1;Q96P48-4;Q96P48-2;Q96P48-5 ENST00000334211;ENST00000359373;ENST00000393605;ENST00000393609 8 0.3467 0.41986 0.19848 0.45752 0.28639 0.26602 Pkinase_Tyr;SH2;SH3_1 cell part;cytoplasmic part;cytosol;endosome;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;organelle;plasma membrane ATP binding;binding;catalytic activity;glycoprotein binding;non-membrane spanning protein tyrosine kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein tyrosine kinase activity;purine nucleoside binding activation of immune response;immune response-activating cell surface receptor signaling pathway;immune response-activating signal transduction;immune system process;positive regulation of immune system process;regulation of immune system process Adherens junction;Axon guidance;Fc epsilon RI signaling pathway;Focal adhesion;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway 9 8 6 17.6 15.7 13.7 60.158 1.9121E-54 41342000 24147000 17195000 5208 IPI:IPI00640091.3;IPI:IPI00219012.4;IPI:IPI00166845.2 Proto-oncogene tyrosine-protein kinase Fyn;p59-Fyn;Protooncogene Syn;SLK FYN P06241-2;P06241;P06241-1;P06241-3 ENST00000229471;ENST00000356013;ENST00000368667;ENST00000368678;ENST00000368682 K05703 3 NaN 1.8224 NaN NaN 1.1265 NaN efhand binding;calcium ion binding;cation binding;ion binding;metal ion binding 2 2 2 7.4 7.4 7.4 49.666 7.5845E-25 2423100 316590 2106500 5210 IPI:IPI00640276.1 EF-hand domain-containing family member A1 EFHA1 Q8IYU8 ENST00000382374 1 0.79863 1.4688 0.82975 1.0493 0.97769 1.0657 FKBP_C;TPR_1 cell part;cytoplasmic part;intracellular organelle part;intracellular part;membrane;mitochondrial membrane;mitochondrial part;organelle membrane;organelle part binding;calcium ion binding;catalytic activity;cation binding;cis-trans isomerase activity;ion binding;isomerase activity;metal ion binding;peptidyl-prolyl cis-trans isomerase activity apoptosis;cell communication;cell death;cellular biopolymer metabolic process;cellular process;death;intracellular signaling cascade;metabolic process;programmed cell death;protein folding;protein metabolic process;signal transduction 9 9 9 29.9 29.9 29.9 44.561 2.3883E-217 317850000 160550000 157300000 5211 IPI:IPI00640341.1;IPI:IPI00328161.8 FK506-binding protein 8;Peptidyl-prolyl cis-trans isomerase;38 kDa FK506-binding protein;FKBPR38 FKBP8;FKBP38 Q14318-1;Q14318;Q14318-2 ENST00000222308 K09574 2 0.34487 1.5297 0.7536 0.43241 0.97903 1.0118 OTU catalytic activity;cysteine-type peptidase activity;hydrolase activity;hydrolase activity, acting on ester bonds;peptidase activity;peptidase activity, acting on L-amino acid peptides;thiolester hydrolase activity;ubiquitin thiolesterase activity catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 2 2 2 4.7 4.7 4.7 60.625 7.0472E-30 38477000 21555000 16922000 5212 IPI:IPI00640364.2;IPI:IPI00641956.1;IPI:IPI00940013.1 OTU domain-containing protein 5;Deubiquinating enzyme A OTUD5 Q96G74-1;Q96G74;Q96G74-3;Q96G74-2 ENST00000156084;ENST00000396743 3 0.68454 1.6735 1.0509 0.90965 1.1148 1.3427 Bromodomain;PHD;PWWP;zf-MYND binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding 3 3 1 2.9 2.9 1 131.58 5.5968E-11 4280200 2306200 1974000 5213 IPI:IPI00640598.1;IPI:IPI00741204.2;IPI:IPI00946867.1;IPI:IPI00748579.1;IPI:IPI00719508.3;IPI:IPI00418316.6 Protein kinase C-binding protein 1;Rack7;Cutaneous T-cell lymphoma-associated antigen se14-3;CTCL tumor antigen se14-3;Zinc finger MYND domain-containing protein 8 ZMYND8;KIAA1125;PRKCBP1;RACK7 Q9ULU4-9;Q9ULU4;Q9ULU4-5;Q9ULU4-1;Q9ULU4-3;Q9ULU4-8;Q9ULU4-7 ENST00000262975;ENST00000311275;ENST00000352431;ENST00000355972 6 0.55674 1.091 0.56547 0.75895 0.6927 0.74943 Xpo1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;protein binding;RNA binding;tRNA binding cellular process;gene silencing;gene silencing by RNA;negative regulation of gene expression;negative regulation of macromolecule metabolic process;negative regulation of metabolic process;regulation of gene expression;regulation of metabolic process 26 26 26 28.2 28.2 28.2 136.31 0 346830000 191680000 155160000 5214 IPI:IPI00640703.3;IPI:IPI00747670.2 Exportin-5;Ran-binding protein 21 XPO5;KIAA1291;RANBP21 Q9HAV4-1;Q9HAV4;Q9HAV4-2 ENST00000265351;ENST00000398799 2 0.91211 1.4243 0.85084 1.1527 0.95601 1.0971 PDZ;PX;RA cell part;cytoplasmic part;cytosol;early endosome;endosome;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle binding;lipid binding;phosphoinositide binding;phospholipid binding;protein binding biological regulation;cell communication;cellular process;establishment of localization;establishment of protein localization;protein transport;regulation of biological process;regulation of cellular process;signal transduction;transport 10 10 10 21.6 21.6 21.6 61.264 1.9951E-60 51982000 29972000 22011000 5215 IPI:IPI00645303.1;IPI:IPI00640980.1;IPI:IPI00328097.4 Sorting nexin-27 SNX27;KIAA0488;My014 Q96L92-1;Q96L92;Q96L92-3;Q96L92-2 ENST00000368841;ENST00000368843 3 0.85132 1.5465 0.83064 1.1037 1.0486 1.0872 zf-UBR cytoplasm;cytoskeleton;integral to membrane;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intrinsic to membrane;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle acid-amino acid ligase activity;binding;calmodulin binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;protein binding;small conjugating protein ligase activity;ubiquitin-protein ligase activity;zinc ion binding catabolic process;cellular biopolymer metabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis 73 73 73 18.2 18.2 18.2 575.95 0 1466800000 781200000 685580000 5216 IPI:IPI00746934.2;IPI:IPI00843999.2;IPI:IPI00640981.3;IPI:IPI00646605.3;IPI:IPI00180305.7;IPI:IPI00386907.4 E3 ubiquitin-protein ligase UBR4;N-recognin-4;Zinc finger UBR1-type protein 1;Retinoblastoma-associated factor of 600 kDa;600 kDa retinoblastoma protein-associated factor;RBAF600;p600 UBR4;KIAA0462;KIAA1307;RBAF600;ZUBR1 Q5T4S7-2;Q5T4S7;Q5T4S7-1;Q5T4S7-4;Q5T4S7-3 ENST00000375254 K10691 6 0.65333 1.275 0.57784 0.85979 0.86271 0.7491 MARCKS cell part;membrane;plasma membrane binding;calmodulin binding;protein binding 2 2 2 11.3 11.3 11.3 19.529 1.3732E-24 198100000 118170000 79935000 5217 IPI:IPI00641181.5 MARCKS-related protein;MARCKS-like protein 1;Macrophage myristoylated alanine-rich C kinase substrate MARCKSL1;MLP;MRP P49006 ENST00000329421 1 0.36949 0.71197 0.35512 0.45949 0.50804 0.42941 Ldl_recept_a cell part;cytoplasmic part;endoplasmic reticulum;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane part;membrane-bounded organelle;organelle binding;growth factor activity;protein binding;receptor binding biological regulation;regulation of biological process;regulation of cell growth;regulation of cellular process;regulation of growth 3 3 3 10.3 10.3 10.3 28.991 2.6606E-09 55622000 28174000 27448000 5219 IPI:IPI00641251.1 CD320 antigen;8D6 antigen;FDC-signaling molecule 8D6;Transcobalamin receptor CD320;8D6A;UNQ198/PRO224 Q9NPF0 ENST00000301458 K06734 1 0.76087 1.5995 0.72054 0.96349 1.0885 0.92699 zf-C3HC4 cell part;cytoplasm;intracellular organelle part;intracellular part;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part binding;cation binding;ion binding;metal ion binding;transcription regulator activity;transcription repressor activity;transition metal ion binding;zinc ion binding catabolic process;macromolecule catabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;proteolysis;regulation of transcription, DNA-dependent;transcription 6 4 4 16.5 12.8 12.8 42.429 3.9013E-32 87883000 45548000 42335000 5220 IPI:IPI00641330.1;IPI:IPI00455876.2 E3 ubiquitin-protein ligase RING1;RING finger protein 1;Polycomb complex protein RING1 RING1;RNF1 Q06587-1;Q06587;Q06587-2 ENST00000374656;ENST00000383079;ENST00000383212 K10695 2 0.81011 1.519 0.77647 1.0227 0.99191 1.042 cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;Golgi apparatus part;Golgi membrane;intracellular organelle part;intracellular part;membrane;membrane part;organelle membrane;organelle part cellular process;establishment of localization;establishment of protein localization;protein transport;transport;vesicle-mediated transport 24 24 24 15.4 15.4 15.4 251.89 5.3666E-150 490630000 187610000 303020000 5221 IPI:IPI00641384.2;IPI:IPI00031242.9;IPI:IPI00166487.3;IPI:IPI00896436.1;IPI:IPI00219314.5 Protein transport protein Sec16A;Protein SEC16 homolog A SEC16A;KIAA0310;SEC16;SEC16L O15027-1;O15027;O15027-5;O15027-3;O15027-4;O15027-2 ENST00000290037;ENST00000313050;ENST00000371706 5 4.0791 8.8882 3.5224 5.138 6.2732 4.8355 BAG;WW cell part;cytoplasmic part;cytosol;intracellular part anti-apoptosis;apoptosis;cell death;cellular biopolymer metabolic process;cellular process;death;metabolic process;programmed cell death;protein folding;protein metabolic process;regulation of apoptosis;regulation of cell death 10 10 10 29.9 29.9 29.9 61.594 5.0023E-188 101850000 35527000 66324000 5222 IPI:IPI00641582.1 BAG family molecular chaperone regulator 3;Bcl-2-associated athanogene 3;Bcl-2-binding protein Bis;Docking protein CAIR-1 BAG3;BIS O95817 ENST00000369085 K09557 1 0.74057 1.399 0.77374 0.97522 0.9433 0.99114 DEAD;Helicase_C cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex ATP binding;ATP-dependent RNA helicase activity;binding;catalytic activity;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;RNA binding;RNA helicase activity nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 23 23 8 50.8 50.8 26.6 50.679 0 7296300000 3818400000 3477800000 5224 IPI:IPI00641829.5;IPI:IPI00848161.1 Spliceosome RNA helicase BAT1;DEAD box protein UAP56;56 kDa U2AF65-associated protein;ATP-dependent RNA helicase p47;HLA-B-associated transcript-1 BAT1;UAP56 Q13838-2;Q13838;Q13838-1 ENST00000376174;ENST00000376185;ENST00000383315;ENST00000383508;ENST00000396172;ENST00000400258;ENST00000400260;ENST00000400295;ENST00000400296 2 0.80525 1.4286 0.62224 0.97143 0.95511 0.83192 Ribosomal_S9 cytoplasmic part;intracellular part;macromolecular complex;mitochondrial part;mitochondrial small ribosomal subunit;organellar small ribosomal subunit;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit binding;protein binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;peptide metabolic process;protein metabolic process;response to DNA damage stimulus;response to stress;translation 10 10 10 24.2 24.2 24.2 45.834 1.0555E-175 140410000 77123000 63291000 5226 IPI:IPI00641924.2 28S ribosomal protein S9, mitochondrial;MRP-S9 MRPS9;RPMS9 P82933 ENST00000258455 1 0.35692 0.61749 0.34772 0.48451 0.4241 0.42216 Las1 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;protein binding 10 10 10 16.2 16.2 16.2 83.064 2.1573E-192 141790000 80569000 61223000 5227 IPI:IPI00641990.1;IPI:IPI00645869.1;IPI:IPI00009917.3;IPI:IPI00152781.3 LAS1-like protein LAS1L;MSTP060 Q9Y4W2-1;Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3 ENST00000312391;ENST00000374807;ENST00000374811 4 0.97036 1.6831 0.93319 1.2245 1.1445 1.2709 tRNA-synt_1c cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;glutamate-tRNA ligase activity;ligase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;RNA binding cellular amino acid and derivative metabolic process;glutamyl-tRNA aminoacylation;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;tRNA aminoacylation for protein translation;tRNA metabolic process Aminoacyl-tRNA biosynthesis;Glutamate metabolism;Porphyrin and chlorophyll metabolism 9 9 9 23.3 23.3 23.3 58.688 3.1391E-87 14235000 7606000 6629000 5228 IPI:IPI00642156.1 Probable glutamyl-tRNA synthetase, mitochondrial;Glutamate--tRNA ligase EARS2;KIAA1970 Q5JPH6 ENST00000341597 K01885 1 NaN 2.3377 1.2452 NaN 1.6366 1.5726 BACK;BTB;Kelch_1 binding;protein binding catabolic process;cell communication;cell surface receptor linked signal transduction;cellular process;macromolecule catabolic process;metabolic process;protein metabolic process;proteolysis;signal transduction;Wnt receptor signaling pathway 3 3 3 5.1 5.1 5.1 67.727 1.6398E-13 2663600 1276500 1387100 5229 IPI:IPI00642182.2 Kelch-like protein 12;CUL3-interacting protein 1 KLHL12;C3IP1 Q53G59 ENST00000367261 K10450 1 0.74982 1.5822 0.75528 0.95047 1.0411 0.97358 Leuk-A4-hydro_C;Peptidase_M1 cell part;extracellular region part;extracellular space;membrane;plasma membrane aminopeptidase activity;binding;catalytic activity;epoxide hydrolase activity;exopeptidase activity;hydrolase activity;hydrolase activity, acting on ether bonds;metalloexopeptidase activity;metallopeptidase activity;peptidase activity;zinc ion binding fatty acid biosynthetic process;fatty acid metabolic process;icosanoid metabolic process;leukotriene metabolic process;lipid metabolic process;metabolic process;organic acid metabolic process;proteolysis;unsaturated fatty acid biosynthetic process 19 19 19 30.1 30.1 30.1 73.497 1.0846E-196 477380000 254440000 222940000 5230 IPI:IPI00642211.3 Aminopeptidase B;Arginine aminopeptidase;Arginyl aminopeptidase RNPEP;APB Q9H4A4 ENST00000295640 K01260 1 0.9051 1.7296 0.92992 1.1711 1.1732 1.1756 Linker_histone cell part;chromosomal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;macromolecular complex;membrane-bounded organelle;nucleosome;nucleus;organelle;organelle part;protein-DNA complex binding;DNA binding;nucleic acid binding anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;chromatin organization;nucleosome assembly;organelle organization 20 20 20 37.3 37.3 37.3 61.206 0 1728600000 887730000 840870000 5231 IPI:IPI00642238.4;IPI:IPI00646486.1;IPI:IPI00871239.1;IPI:IPI00448752.1 Heterochromatin protein 1-binding protein 3;Protein HP1-BP74 HP1BP3 Q5SSJ5-1;Q5SSJ5;Q5SSJ5-2;Q5SSJ5-3 ENST00000312239;ENST00000400444 4 0.91347 1.7293 0.88621 1.1977 1.1356 1.1913 F_actin_cap_B cell part;cytoplasm;cytoskeletal part;F-actin capping protein complex;intracellular organelle part;intracellular part;macromolecular complex;organelle part;protein complex actin binding;binding;cytoskeletal protein binding;protein binding cell motion;cellular process;cytoskeleton organization;negative regulation of macromolecule metabolic process;negative regulation of metabolic process;organelle organization;regulation of actin polymerization or depolymerization 24 24 24 71.7 71.7 71.7 30.628 0 4475700000 2307000000 2168800000 5232 IPI:IPI00642256.2;IPI:IPI00026185.7 F-actin-capping protein subunit beta;CapZ beta CAPZB P47756-2;P47756;P47756-1 ENST00000264202;ENST00000375142;ENST00000401084 K10365 2 0.55351 1.141 0.98884 0.69225 0.76558 1.1785 Dynamin_N;Fzo_mitofusin cytoplasmic part;cytosol;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;intrinsic to mitochondrial outer membrane;intrinsic to organelle membrane;membrane part;mitochondrial part;organelle part binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleotide binding;pyrophosphatase activity intracellular protein transport;membrane fusion;mitochondrial fusion;mitochondrial membrane organization;mitochondrial transport;mitochondrion organization;organelle organization;protein targeting;protein targeting to mitochondrion;transport 9 9 9 12.3 12.3 12.3 86.401 8.3612E-17 45012000 24836000 20176000 5233 IPI:IPI00642329.2;IPI:IPI00902732.2 Mitofusin-2;Transmembrane GTPase MFN2 MFN2;CPRP1;KIAA0214 O95140-1;O95140;O95140-2 ENST00000235329 K06030 2 0.83187 1.7167 0.79283 1.041 1.1728 0.99515 DUF1620 cell part;integral to membrane;intrinsic to membrane;membrane part binding;protein binding 19 19 19 27 27 27 111.76 0 222600000 116620000 105980000 5235 IPI:IPI00642584.2;IPI:IPI00784543.1;IPI:IPI00645487.2;IPI:IPI00642244.2 Uncharacterized protein KIAA0090 KIAA0090;PSEC0263 Q8N766-1;Q8N766;Q8N766-2;Q8N766-3;Q8N766-4 ENST00000375199;ENST00000375208 4 0.73165 NaN NaN 0.90478 NaN NaN Myosin_head;Myosin_N;Myosin_tail_1 cytoplasmic part;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;membrane;muscle myosin complex;myosin complex;myosin filament;myosin II complex;organelle part;protein complex;striated muscle thick filament actin binding;ATP binding;binding;catalytic activity;cytoskeletal protein binding;hydrolase activity;motor activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity multicellular organismal process;muscle contraction;muscle system process;striated muscle contraction;system process 4 3 2 1.7 1.2 0.9 225.84 6.7867E-07 690740 411300 279440 5236 IPI:IPI00642716.6 Myosin-7B;Myosin heavy chain 7B, cardiac muscle beta isoform;Myosin cardiac muscle beta chain;Antigen MLAA-21;Slow A MYH14 MYH7B;KIAA1512 A7E2Y1-1;A7E2Y1 ENST00000262873;ENST00000374615 1 0.92388 1.7155 1.0071 1.2026 1.1265 1.2646 SRP9 intracellular part;macromolecular complex;membrane part;organelle part;protein complex;receptor complex;ribonucleoprotein complex;signal recognition particle receptor complex;signal recognition particle, endoplasmic reticulum targeting 7S RNA binding;binding;nucleic acid binding;protein binding;ribonucleoprotein binding;RNA binding;signal recognition particle binding cotranslational protein targeting to membrane;protein targeting;protein targeting to membrane;regulation of translation;regulation of translational elongation;SRP-dependent cotranslational protein targeting to membrane;transport Protein export 4 4 4 44.2 44.2 44.2 10.112 8.4192E-49 780350000 388160000 392180000 5237 IPI:IPI00642816.2 Signal recognition particle 9 kDa protein SRP9 P49458 ENST00000304786;ENST00000318333 K03109 1 0.91169 1.8673 1.0378 1.2255 1.1958 1.397 Pro_isomerase;RRM_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;cis-trans isomerase activity;isomerase activity;nucleic acid binding;nucleotide binding;peptidyl-prolyl cis-trans isomerase activity;RNA binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 11 11 11 21.5 21.5 21.5 57.224 3.8059E-50 173240000 88330000 84912000 5238 IPI:IPI00642862.1 Peptidyl-prolyl cis-trans isomerase-like 4;Cyclophilin-like protein PPIL4 PPIL4 Q8WUA2 ENST00000253329 K01802 1 NaN NaN 0.71969 NaN NaN 0.92182 EF-1_beta_acid;EF1_GNE cell part;cytoplasmic part;cytosol;eukaryotic translation elongation factor 1 complex;intracellular part;macromolecular complex;protein complex binding;molecular transducer activity;nucleic acid binding;protein binding;signal transducer activity;translation elongation factor activity;translation factor activity, nucleic acid binding;translation regulator activity biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;positive regulation of signal transduction;regulation of protein kinase cascade;regulation of signal transduction;translational elongation 14 1 1 23.5 2.6 2.6 71.407 0 1932800 907080 1025700 5239 IPI:IPI00642971.3 Elongation factor 1-delta;Antigen NY-CO-4 EEF1D;EF1D P29692-2;P29692 ENST00000337369;ENST00000356793;ENST00000395119 1 0.773 1.5359 0.76038 1.0392 0.99037 1.0355 Ras cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;cytosol;intracellular organelle;macromolecular complex;melanosome;membrane-bounded organelle;membrane-bounded vesicle;nuclear pore;nucleoplasm;organelle;vesicle binding;catalytic activity;chromatin binding;GTP binding;GTPase activity;nucleotide binding;protein binding;pyrophosphatase activity;receptor binding;transcription coactivator activity;transcription cofactor activity;transcription factor binding DNA metabolic process;microtubule cytoskeleton organization;nuclear division;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein targeting;regulation of transcription, DNA-dependent;RNA export from nucleus 19 19 19 56.9 56.9 56.9 24.423 2.8154E-276 12147000000 6443000000 5704200000 5240 IPI:IPI00643041.3 GTP-binding nuclear protein Ran;GTPase Ran;Ras-related nuclear protein;Ras-like protein TC4;Androgen receptor-associated protein 24 RAN;ARA24;OK/SW-cl.81 P62826 ENST00000254675;ENST00000392369 K07936 1 0.67849 NaN 0.72263 0.90562 NaN 0.9678 DUF1731 binding;catalytic activity metabolic process 2 2 2 5.6 5.6 5.6 34.747 0.00089002 15623000 9045800 6577400 5241 IPI:IPI00829615.2;IPI:IPI00643286.4;IPI:IPI00829668.1 Epimerase family protein SDR39U1;Short chain dehydrogenase/reductase family 39U member 1 SDR39U1;C14orf124;HCDI Q9NRG7-1;Q9NRG7;Q9NRG7-2;Q9NRG7-3 ENST00000336353;ENST00000399390;ENST00000399395 K07071 3 0.83458 1.5645 NaN 1.0847 1.0078 NaN Robl_LC7 cell part;cytoplasm;cytoplasmic dynein complex;cytoskeletal part;dynein complex;intracellular organelle part;intracellular part;macromolecular complex;microtubule;microtubule associated complex;organelle part;protein complex binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;microtubule motor activity;motor activity;protein binding;pyrophosphatase activity behavior;cellular process;microtubule-based movement;microtubule-based process;multicellular organismal process;response to abiotic stimulus;response to light stimulus;response to radiation;response to stimulus;visual behavior 3 3 3 47.9 47.9 47.9 10.921 3.0764E-52 41071000 20457000 20614000 5242 IPI:IPI00643583.2;IPI:IPI00178188.5;IPI:IPI00063849.3 Dynein light chain roadblock-type 1;Dynein light chain 2A, cytoplasmic;Dynein-associated protein Km23;Roadblock domain-containing protein 1;Bithoraxoid-like protein;Dynein light chain roadblock-type 2;Dynein light chain 2B, cytoplasmic;Roadblock domain-containing protein 2 DYNLRB1;BITH;DNCL2A;DNLC2A;ROBLD1;HSPC162;DYNLRB2;DNCL2B;DNLC2B;ROBLD2 Q9NP97-1;Q9NP97;Q8TF09 ENST00000300469;ENST00000357156;ENST00000374846;ENST00000305904 K10419 3 0.7529 1.459 0.78627 0.98632 0.97265 0.99677 ARID cell part;chromatin remodeling complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex;SWI/SNF complex;SWI/SNF-type complex binding;DNA binding;nucleic acid binding;protein binding;transcription activator activity;transcription regulator activity cell communication;chromatin organization;chromatin remodeling;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;regulation of transcription, DNA-dependent;transcription 21 21 20 12.7 12.7 11.9 242.04 1.4979E-234 452980000 244280000 208700000 5243 IPI:IPI00643722.1;IPI:IPI00642705.1;IPI:IPI00929427.1 AT-rich interactive domain-containing protein 1A;ARID domain-containing protein 1A;SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1;SWI-SNF complex protein p270;B120;SWI-like protein;Osa homolog 1;BRG1-associated factor 250;BRG1-associated factor 250a ARID1A;C1orf4;OSA1;SMARCF1 O14497-1;O14497;O14497-2;O14497-3 ENST00000324856 K11653 3 0.16442 NaN NaN 0.22319 NaN NaN WD40 cell part;cytoplasm;intracellular organelle part;intracellular part;membrane;nuclear membrane;nuclear part;organelle membrane;organelle part binding;protein binding catabolic process;DNA metabolic process;DNA replication;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;proteolysis;response to DNA damage stimulus;response to stress 2 2 2 3 3 3 79.44 3.12E-09 1822400 991600 830760 5244 IPI:IPI00643808.2 Denticleless protein homolog;Lethal(2) denticleless protein homolog;Ddb1- and Cul4-associated factor 2;Retinoic acid-regulated nuclear matrix-associated protein DTL;CDT2;CDW1;DCAF2;L2DTL;RAMP Q9NZJ0-1;Q9NZJ0 ENST00000318866;ENST00000366991 K11790 1 0.7363 1.5687 0.84259 0.99654 0.96088 1.2201 6 6 6 24.4 24.4 24.4 39.367 2.8548E-73 52254000 28069000 24185000 5245 IPI:IPI00643818.2;IPI:IPI00167998.3;IPI:IPI00871233.1 UPF0667 protein C1orf55 C1orf55 Q6IQ49-3;Q6IQ49;Q6IQ49-1;Q6IQ49-2 ENST00000272091;ENST00000366818 3 0.58496 1.2969 0.83537 0.80559 0.80263 1.1109 Helicase_C;RNA_pol_L;SNF2_N cell part;chromatin;chromosomal part;heterochromatin;intracellular organelle part;intracellular part;nuclear chromatin;nuclear chromosome part;nuclear heterochromatin;nuclear part;nucleoplasm;organelle part binding;catalytic activity;DNA binding;DNA-directed RNA polymerase activity;nucleic acid binding;nucleotidyltransferase activity;protein binding;RNA polymerase activity;transferase activity;transferase activity, transferring phosphorus-containing groups biosynthetic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription RNA polymerase + 2 1 1 13.9 5.7 5.7 14.332 1.5073E-05 13048000 7305800 5742200 5246 IPI:IPI00643892.1;IPI:REV_IPI00297633.6;IPI:REV_IPI00845355.1;IPI:REV_IPI00220109.6;IPI:REV_IPI00938010.1;IPI:REV_IPI00883721.2;IPI:REV_IPI00940810.1 DNA-directed RNA polymerases I and III subunit RPAC2;DNA-directed RNA polymerase I 16 kDa polypeptide;RPC16;hRPA19;AC19;Transcriptional regulator ATRX;ATP-dependent helicase ATRX;X-linked helicase II;X-linked nuclear protein;Znf-HX POLR1D;ATRX;RAD54L;XH2 Q9Y2S0-2;Q9Y2S0;P46100-1;P46100;P46100-4;P46100-5;P46100-3;P46100-2;P46100-6 ENST00000302979;ENST00000399696;ENST00000399697;ENST00000343347;ENST00000373342;ENST00000373344;ENST00000395603;ENST00000395605;ENST00000400870;ENST00000400871 K03020;K10779 7 0.83684 1.5491 0.83967 1.0767 1.0186 1.0771 Anticodon_1;tRNA-synt_1 cell fraction;cell part;cytoplasm;intracellular part;soluble fraction aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;isoleucine-tRNA ligase activity;ligase activity;ligase activity, forming carbon-oxygen bonds;nucleoside binding;nucleotide binding;purine nucleoside binding;zinc ion binding cellular amino acid and derivative metabolic process;isoleucyl-tRNA aminoacylation;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;tRNA aminoacylation for protein translation;tRNA metabolic process 50 50 50 42.7 42.7 42.7 144.5 0 5574300000 2855600000 2718700000 5248 IPI:IPI00644127.2 Isoleucyl-tRNA synthetase, cytoplasmic;Isoleucine--tRNA ligase IARS P41252 ENST00000375660 1 0.73609 1.2996 0.73074 0.90554 0.92895 0.92071 FragX_IP cell fraction;cell junction;cell part;cell projection;cytoplasmic part;insoluble fraction;intracellular part;lamellipodium;membrane fraction;membrane part;perinuclear region of cytoplasm;plasma membrane part;ruffle;synapse;synaptosome actin binding;actin filament binding;binding;cytoskeletal protein binding;enzyme binding;GTPase binding;protein binding;Rac GTPase binding;Ras GTPase binding;Rho GTPase binding;small GTPase binding anatomical structure formation;anatomical structure morphogenesis;axonogenesis;cellular component organization;cellular process;regulation of anatomical structure morphogenesis;regulation of cell morphogenesis;regulation of cell shape Regulation of actin cytoskeleton 15 5 3 13.2 4.3 2.4 145.18 6.0076E-102 25944000 14421000 11523000 5249 IPI:IPI00644231.3 Cytoplasmic FMR1-interacting protein 1;Specifically Rac1-associated protein 1;p140sra-1 CYFIP1;KIAA0068 Q7L576-1;Q7L576 ENST00000313077 K05749 1 0.68638 1.1437 0.63449 0.9172 0.78626 0.82833 Anticodon_1;tRNA-synt_1 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-oxygen bonds;nucleoside binding;nucleotide binding;purine nucleoside binding;valine-tRNA ligase activity cellular amino acid and derivative metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;tRNA aminoacylation for protein translation;tRNA metabolic process;valyl-tRNA aminoacylation Aminoacyl-tRNA biosynthesis;Valine, leucine and isoleucine biosynthesis 9 9 9 10.1 10.1 10.1 118.46 7.1784E-100 95324000 40137000 55187000 5251 IPI:IPI00644468.1;IPI:IPI00895822.1 Valyl-tRNA synthetase, mitochondrial;Valine--tRNA ligase;Valyl-tRNA synthetase-like VARS2;KIAA1885;VARS2L;VARSL Q5ST30-1;Q5ST30;Q5ST30-2 ENST00000383369 K01873 2 0.82595 1.3987 0.77728 1.0686 0.96553 1.0355 HCCA3 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex assembly;cellular macromolecular complex subunit organization;cellular process;proteasome assembly;protein complex assembly 8 8 8 24.6 24.6 24.6 29.396 4.4784E-23 440420000 232140000 208280000 5252 IPI:IPI00644482.1 Proteasome assembly chaperone 2;Tumor necrosis factor superfamily member 5-induced protein 1;Hepatocellular carcinoma-susceptibility protein 3 PSMG2;HCCA3;PAC2;TNFSF5IP1 Q969U7 ENST00000317615 K11876 1 0.81607 1.5709 0.73179 1.0458 1.1059 1.0019 ParA cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding 4 4 4 27.7 27.7 27.7 28.825 9.3471E-47 32395000 17508000 14887000 5253 IPI:IPI00644674.1 Nucleotide-binding protein 2 NUBP2 Q9Y5Y2 ENST00000262302 1 0.91733 1.7309 0.88379 1.2143 1.223 1.1439 SOUL cell part;cytoplasm;intracellular part 7 7 7 33.2 33.2 33.2 24.029 1.8793E-72 184170000 92815000 91354000 5254 IPI:IPI00644697.2;IPI:IPI00003799.2 Heme-binding protein 2;Placental protein 23;Protein SOUL HEBP2;C6orf34;SOUL Q9Y5Z4-1;Q9Y5Z4;Q9Y5Z4-2 ENST00000058691 2 0.71526 NaN NaN 0.88781 NaN NaN AA_permease basolateral plasma membrane;cell part;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part amine transmembrane transporter activity;amino acid transmembrane transporter activity;antiporter activity;organic acid transmembrane transporter activity;secondary active transmembrane transporter activity;transporter activity amine metabolic process;amino acid transport;cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;metabolic process;nitrogen compound metabolic process;organic acid metabolic process;protein complex assembly;transport 2 1 1 2.9 1.6 1.6 56.827 0.00051368 1662000 928810 733170 5255 IPI:IPI00644701.1 Y+L amino acid transporter 2;y(+)L-type amino acid transporter 2;Cationic amino acid transporter, y+ system;Solute carrier family 7 member 6 SLC7A6;KIAA0245 Q92536 ENST00000219343 1 0.63786 1.359 0.62711 0.86116 0.8532 0.85604 Ku;Ku_C;Ku_N;SAP cell fraction;DNA-dependent protein kinase-DNA ligase 4 complex;insoluble fraction;macromolecular complex;membrane fraction;nuclear telomere cap complex;organelle part;protein complex;protein-DNA complex;telomere cap complex;transcription factor complex ATP-dependent DNA helicase activity;ATP-dependent helicase activity;binding;catalytic activity;DNA binding;DNA helicase activity;double-stranded DNA binding;helicase activity;nucleic acid binding;protein binding;protein C-terminus binding DNA ligation;DNA metabolic process;DNA repair;double-strand break repair;double-strand break repair via nonhomologous end joining;non-recombinational repair;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;telomere maintenance Non-homologous end-joining 51 51 51 59.9 59.9 59.9 69.842 0 11157000000 5949300000 5207400000 5256 IPI:IPI00644712.4;IPI:IPI00216710.1;IPI:IPI00418178.5 ATP-dependent DNA helicase 2 subunit 1;ATP-dependent DNA helicase II 70 kDa subunit;Lupus Ku autoantigen protein p70;70 kDa subunit of Ku antigen;Thyroid-lupus autoantigen;CTC box-binding factor 75 kDa subunit;DNA repair protein XRCC6 XRCC6;G22P1 P12956 ENST00000359308;ENST00000360079;ENST00000405878 K10884 3 0.61935 1.5297 0.53325 0.82074 0.97707 0.70916 CBS;IMPDH cell part;cytoplasmic part;cytosol;intracellular part binding;catalytic activity;IMP dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;potassium ion binding GMP biosynthetic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;system process 22 20 20 41.6 38.5 38.5 60.437 1.2023E-277 302600000 166980000 135620000 5257 IPI:IPI00644730.1;IPI:IPI00916697.1;IPI:IPI00647813.1 Inosine-5'-monophosphate dehydrogenase 1;IMPDH-I;IMPD 1 IMPDH1;IMPD1 P20839-3;P20839;P20839-1;P20839-2 ENST00000338791;ENST00000343214;ENST00000348127;ENST00000354269 3 0.91311 1.6999 0.95551 1.1861 1.1629 1.2485 G-alpha extrinsic to membrane;extrinsic to plasma membrane;Golgi membrane;heterotrimeric G-protein complex;intracellular part;intrinsic to membrane;macromolecular complex;membrane;organelle membrane;organelle part;protein complex;trans-Golgi network membrane binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity;signal transducer activity activation of adenylate cyclase activity;cell communication;cell surface receptor linked signal transduction;G-protein coupled receptor protein signaling pathway;regulation of nucleotide metabolic process;signal transduction;system process;transport Calcium signaling pathway;Gap junction;GnRH signaling pathway;Long-term depression;Melanogenesis;Taste transduction;Vascular smooth muscle contraction;Vibrio cholerae infection 16 15 15 43.8 40.9 40.9 44.179 1.1962E-82 472560000 238810000 233740000 5258 IPI:IPI00644936.1;IPI:IPI00095891.2;IPI:IPI00646491.2;IPI:IPI00514055.1;IPI:IPI00219835.1;IPI:IPI00006395.1 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Adenylate cyclase-stimulating G alpha protein;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas;Extra large alphas protein GNAS;GNAS1;GSP P63092-3;P63092;Q5JWF2-1;Q5JWF2;Q5JWF2-2;P63092-1;P63092-2 ENST00000265620;ENST00000371082;ENST00000371085;ENST00000371100 K04632 6 0.53663 1.053 0.61805 0.64938 0.72877 0.78819 cell part;integrator complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;protein binding cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;snRNA metabolic process;snRNA processing 6 6 6 9 9 9 106.83 6.4107E-26 21930000 11985000 9945100 5260 IPI:IPI00743871.2;IPI:IPI00645022.2;IPI:IPI00645488.2 Integrator complex subunit 7 INTS7;C1orf73 Q9NVH2-1;Q9NVH2;Q9NVH2-2;Q9NVH2-3 ENST00000366994 3 0.82029 1.5271 0.81426 1.055 1.0083 1.0729 ThiF;UBA_e1_C;UBA_e1_thiolCys;UBACT cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle adenyl nucleotide binding;ATP binding;binding;catalytic activity;ligase activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;ribonucleotide binding;small protein activating enzyme activity catabolic process;cell death;cellular process;death;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;protein modification process;proteolysis Parkinson's disease;Ubiquitin mediated proteolysis 37 37 37 48.7 48.7 48.7 117.85 0 9435900000 4850500000 4585400000 5261 IPI:IPI00645078.1 Ubiquitin-like modifier-activating enzyme 1;Ubiquitin-activating enzyme E1;Protein A1S9 UBA1;A1S9T;UBE1 P22314 ENST00000335972;ENST00000377351 K03178 1 0.7566 1.5454 0.75828 0.99923 1.0132 1.0027 cell part;integral to membrane;intrinsic to membrane;membrane part 9 9 9 20.1 20.1 20.1 63.626 4.6708E-91 291770000 149720000 142050000 5263 IPI:IPI00719170.1;IPI:IPI00645440.2;IPI:IPI00019248.3 TRAF3-interacting JNK-activating modulator;TRAF3-interacting protein 3 TRAF3IP3;T3JAM Q9Y228-1;Q9Y228;Q9Y228-2;Q9Y228-3 ENST00000010338;ENST00000367024;ENST00000367025 3 NaN 1.7356 NaN NaN 1.1093 NaN Rhodanese cell part;cytoplasmic part;intracellular part;perinuclear region of cytoplasm catalytic activity;sulfurtransferase activity;thiosulfate sulfurtransferase activity;transferase activity;transferase activity, transferring sulfur-containing groups 2 2 1 23.9 23.9 11 11.75 0.00015868 3329300 1908700 1420600 5264 IPI:IPI00645501.1 Putative thiosulfate sulfurtransferase KAT KAT Q8NFU3-3;Q8NFU3 ENST00000318289;ENST00000368025 1 0.54885 1.0991 0.46977 0.73495 0.72754 0.64687 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 14 14 14 39.6 39.6 39.6 61.687 5.7364E-127 88987000 47698000 41289000 5266 IPI:IPI00645608.2 Interferon regulatory factor 2-binding protein 1 IRF2BP1 Q8IU81 ENST00000302165 1 NaN 1.9809 NaN NaN 1.3101 NaN MAP65_ASE1 cell part;cytoplasm;cytoskeletal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;microtubule;nucleus;organelle;organelle part;spindle microtubule binding;protein binding cell cycle process;cell division;cellular process;cytokinesis;microtubule-based process;mitotic spindle elongation;spindle elongation 4 4 1 10.8 10.8 2.8 66.595 2.6121E-28 7842800 4902900 2939900 5267 IPI:IPI00645623.2 Protein regulator of cytokinesis 1 PRC1 O43663-2;O43663 ENST00000361919;ENST00000394249 1 0.81113 1.793 0.86409 1.0929 1.1456 1.1746 4 4 4 11.2 11.2 11.2 38.141 2.7628E-21 49140000 24537000 24603000 5268 IPI:IPI00645766.2;IPI:IPI00477669.3;IPI:IPI00847580.1;IPI:IPI00853527.1 Uncharacterized protein KIAA1704;Lipopolysaccharide-specific response protein 7 KIAA1704;LSR7;AD029 Q8IXQ4-1;Q8IXQ4;Q8IXQ4-2;Q8IXQ4-3 ENST00000361121;ENST00000361481;ENST00000379151 4 0.87456 1.781 0.75947 1.1402 1.1527 0.9685 Acyl-CoA_dh_1;Acyl-CoA_dh_M;Acyl-CoA_dh_N cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part acyl-CoA dehydrogenase activity;binding;catalytic activity;electron carrier activity;isovaleryl-CoA dehydrogenase activity;nucleoside binding;nucleotide binding;oxidoreductase activity;purine nucleoside binding metabolic process;oxidation reduction Valine, leucine and isoleucine degradation 8 8 8 16.5 16.5 16.5 46.319 6.8611E-59 156950000 80774000 76179000 5269 IPI:IPI00645805.4 Isovaleryl-CoA dehydrogenase, mitochondrial IVD P26440 ENST00000249760 K00253 1 0.87001 1.6197 NaN 1.1591 0.97874 NaN DUF729 cell part;cytoplasm;intracellular part 3 3 3 13.4 13.4 13.4 31.957 6.3091E-08 7891000 3503800 4387200 5270 IPI:IPI00936230.1;IPI:IPI00645882.1;IPI:IPI00470480.3 Protein FAM54B FAM54B;HYST1888;MSTP116 Q9H019-1;Q9H019;Q9H019-3 ENST00000336146;ENST00000374300;ENST00000374301 3 0.79766 NaN 0.77083 1.0327 NaN 1.0251 Alpha_kinase;I-set ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cellular biopolymer metabolic process;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process 2 2 2 1 1 1 237.01 0.0054124 45492000 23887000 21605000 5272 IPI:IPI00792557.1;IPI:IPI00646010.3 Alpha-protein kinase 2;Heart alpha-protein kinase ALPK2;HAK Q86TB3-1;Q86TB3;Q86TB3-2 ENST00000361673;ENST00000398254 2 0.6136 1.1416 0.81663 0.82627 0.8221 1.0452 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex binding;protein binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding;transcription regulator activity cellular process;regulation of biosynthetic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription initiation;transcription initiation from RNA polymerase II promoter 13 13 13 11.3 11.3 11.3 156.47 9.5697E-49 54743000 29207000 25535000 5273 IPI:IPI00844220.1;IPI:IPI00646226.1;IPI:IPI00867654.1;IPI:IPI00413272.3;IPI:IPI00472333.1 Mediator of RNA polymerase II transcription subunit 23;Mediator complex subunit 23;Cofactor required for Sp1 transcriptional activation subunit 3;CRSP complex subunit 3;Transcriptional coactivator CRSP130;Vitamin D3 receptor-interacting protein complex 130 kDa component;Activator-recruited cofactor 130 kDa component MED23;ARC130;CRSP3;DRIP130;KIAA1216;SUR2 Q9ULK4-1;Q9ULK4;Q9ULK4-5;Q9ULK4-4;Q9ULK4-3;Q9ULK4-2 ENST00000368058;ENST00000368068;ENST00000403834 5 1.0592 2.2794 1.0625 1.4356 1.4335 1.403 Pro_isomerase cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;endoplasmic reticulum;endoplasmic reticulum lumen;intracellular organelle;melanosome;membrane-bounded organelle;membrane-bounded vesicle;membrane-enclosed lumen;organelle;vesicle binding;catalytic activity;cis-trans isomerase activity;isomerase activity;peptide binding;peptidyl-prolyl cis-trans isomerase activity;protein binding;unfolded protein binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 18 18 18 67.6 67.6 67.6 23.742 0 5665500000 2783900000 2881600000 5275 IPI:IPI00646304.4 Peptidyl-prolyl cis-trans isomerase B;Cyclophilin B;S-cyclophilin;CYP-S1 PPIB;CYPB P23284 ENST00000300026 K03768 1 0.8055 1.4562 NaN 1.0792 0.91872 NaN DUF1741 cell part;integral to membrane;intrinsic to membrane;membrane part 3 3 3 5.2 5.2 5.2 78.71 1.4031E-66 5888200 3363500 2524700 5276 IPI:IPI00646323.2;IPI:IPI00843920.1 UPF0668 protein C10orf76 C10orf76 Q5T2E6-1;Q5T2E6 ENST00000370033 2 1.4882 1.6153 0.86887 1.8196 1.0446 1.1727 MA3;MIF4G;W2 cell part;cytoplasmic part;eukaryotic translation initiation factor 4F complex;intracellular part;macromolecular complex;protein complex binding;nucleic acid binding;protein binding;RNA binding;RNA cap binding;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of translation;regulation of translational initiation;translation 12 6 6 7.6 3.9 3.9 176.65 2.1762E-87 88155000 42021000 46134000 5277 IPI:IPI00646377.1 Eukaryotic translation initiation factor 4 gamma 3;eIF-4-gamma II EIF4G3 O43432-1;O43432 ENST00000264211;ENST00000400422 K03260 1 0.86578 1.8047 NaN 1.0856 1.165 NaN ABC_membrane;ABC_tran cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part ATP binding;binding;catalytic activity;nucleoside binding;nucleotide binding;oligopeptide transporter activity;peptide transporter activity;primary active transmembrane transporter activity;protein binding;purine nucleoside binding;transporter activity establishment of localization;establishment of protein localization;immune response;immune system process;oligopeptide transport;peptide transport;protein transport;response to stimulus;transport ABC transporters;Antigen processing and presentation;Primary immunodeficiency 2 2 2 4.8 4.8 4.8 87.217 3.4675E-114 4762700 2792600 1970100 5280 IPI:IPI00646625.1 Antigen peptide transporter 1;Peptide transporter TAP1;ATP-binding cassette sub-family B member 2;Peptide supply factor 1;Peptide transporter PSF1;Peptide transporter involved in antigen processing 1 TAP1;ABCB2;PSF1;RING4;Y3 Q03518 ENST00000354258;ENST00000383115;ENST00000383235 K05653 1 0.79331 1.4004 0.78431 0.99774 0.97645 0.99148 DUF953 cell part;cytoplasmic part;cytosol;intracellular part antioxidant activity;binding;catalytic activity;electron carrier activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;oxidoreductase activity, acting on sulfur group of donors;peroxidase activity;protein binding cell communication;cell surface receptor linked signal transduction;cellular process;cytokine-mediated signaling pathway;regulation of biological process;regulation of cellular process;signal transduction;tumor necrosis factor-mediated signaling pathway 5 5 5 39.8 39.8 39.8 13.941 2.7944E-122 797830000 424180000 373650000 5281 IPI:IPI00646689.1 Thioredoxin domain-containing protein 17;Thioredoxin-like protein 5;14 kDa thioredoxin-related protein;TRP14;Protein 42-9-9 TXNDC17;TXNL5 Q9BRA2 ENST00000250101 1 0.75095 3.9183 0.47019 1.0182 2.4569 0.6475 Gelsolin actin cytoskeleton;cell part;cytoplasmic part;cytoskeleton;cytosol;extracellular region;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle actin binding;binding;calcium ion binding;cation binding;cytoskeletal protein binding;ion binding;metal ion binding;protein binding actin filament organization;actin polymerization or depolymerization;cellular process;cytoskeleton organization;negative regulation of metabolic process;organelle organization;protein complex assembly;regulation of actin polymerization or depolymerization Regulation of actin cytoskeleton + 6 6 6 11.4 11.4 11.4 85.696 3.2876E-33 15006000 10173000 4833000 5282 IPI:IPI00026314.1;IPI:IPI00646773.2;IPI:CON_00694255.1 Gelsolin;Actin-depolymerizing factor;Brevin;AGEL GSN P06396-1;P06396;P06396-2;Q3SX14 ENST00000341272;ENST00000373818 K05768 3 0.83327 1.4646 0.77978 1.1005 0.986 0.9985 NUDIX centrosome;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;microtubule organizing center;non-membrane-bounded organelle;nuclear body;nuclear part;organelle;organelle part;paraspeckles binding;catalytic activity;hydrolase activity;nucleic acid binding;protein binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 13 13 13 52 52 52 26.227 9.0817E-193 1104300000 575850000 528490000 5284 IPI:IPI00646917.1 Cleavage and polyadenylation specificity factor subunit 5;Cleavage and polyadenylation specificity factor 25 kDa subunit;Pre-mRNA cleavage factor Im 25 kDa subunit;Nucleoside diphosphate-linked moiety X motif 21 NUDT21;CFIM25;CPSF25;CPSF5 O43809 ENST00000300291 1 1.5771 2.6988 1.4832 2.0569 1.7278 1.9964 GKAP centrosome;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;microtubule organizing center;non-membrane-bounded organelle;nucleus;organelle;spindle pole centrosome binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;phosphatase activity;phosphoprotein phosphatase activity;phosphoric ester hydrolase activity;protein binding cell communication;cell proliferation;cell-cell signaling;cellular process;mitotic chromosome movement towards spindle pole;regulation of cell cycle process;regulation of mitosis;regulation of mitotic cell cycle 15 15 15 24 24 24 95.114 1.406E-153 301840000 122850000 178990000 5285 IPI:IPI00647892.1;IPI:IPI00647106.1 Disks large-associated protein 5;Disks large-associated protein DLG7;Discs large homolog 7;Hepatoma up-regulated protein DLGAP5;DLG7;KIAA0008 Q15398-2;Q15398;Q15398-1 ENST00000247191;ENST00000341764 2 NaN NaN 0.86674 NaN NaN 1.1196 TB2_DP1_HVA22 cell part;integral to membrane;intrinsic to membrane;membrane part 2 2 2 12.5 12.5 12.5 20.733 5.8284E-36 13047000 9142600 3904000 5286 IPI:IPI00647161.1 Receptor expression-enhancing protein 6;Polyposis locus protein 1-like 1 REEP6;C19orf32;DP1L1 Q96HR9 ENST00000233596;ENST00000395484 1 0.83282 1.5091 0.75972 1.0869 0.97767 1.0214 LIM cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding anatomical structure development;anatomical structure morphogenesis;cell differentiation;cell growth;cellular developmental process;cellular process;developmental process;growth;muscle organ development;organ development;organ morphogenesis 9 9 9 36.1 36.1 36.1 31.895 1.8492E-39 55751000 30811000 24940000 5287 IPI:IPI00647207.3;IPI:IPI00055606.2;IPI:IPI00644668.2 Four and a half LIM domains protein 1;Skeletal muscle LIM-protein 1 FHL1;SLIM1 Q13642-1;Q13642;Q13642-2;Q13642-3 ENST00000345434;ENST00000370676;ENST00000370690;ENST00000394153;ENST00000394155 3 0.49477 0.99688 0.55249 0.6549 0.65426 0.72572 DEAD;DSHCT;Helicase_C intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;ribonucleoprotein complex;spliceosomal complex ATP binding;ATP-dependent helicase activity;binding;catalytic activity;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing Folate biosynthesis 29 29 29 35.2 35.2 35.2 117.8 1.6999E-222 1135400000 650750000 484630000 5288 IPI:IPI00647217.2 Superkiller viralicidic activity 2-like 2;ATP-dependent helicase SKIV2L2 SKIV2L2;KIAA0052 P42285 ENST00000230640 K01529 1 1.91 3.4563 NaN 2.5619 2.2132 NaN Exonuc_X-T cell part;intracellular organelle part;intracellular part;nuclear body;nuclear part;nucleoplasm part;organelle part;PML body 3'-5'-exoribonuclease activity;binding;catalytic activity;deoxyribonuclease activity;exodeoxyribonuclease activity;exonuclease activity;exoribonuclease activity;nuclease activity;nucleic acid binding;ribonuclease activity;RNA binding cell proliferation;DNA catabolic process;DNA catabolic process, exonucleolytic;DNA metabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA catabolic process 2 2 2 12.2 12.2 12.2 20.363 2.0992E-09 3653000 1960100 1693000 5289 IPI:IPI00647246.1;IPI:IPI00514614.1 Interferon-stimulated gene 20 kDa protein;Promyelocytic leukemia nuclear body-associated protein ISG20;Estrogen-regulated transcript 45 protein ISG20;HEM45 Q96AZ6-1;Q96AZ6;Q96AZ6-2 ENST00000306072;ENST00000379224;ENST00000405917 K01147 2 0.61457 NaN 0.5506 0.79436 NaN 0.69049 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;tRNA metabolic process;tRNA processing 7 7 7 12.5 12.5 12.5 67.315 6.1609E-68 26351000 14590000 11761000 5290 IPI:IPI00647491.1;IPI:IPI00004584.1;IPI:IPI00915950.1;IPI:IPI00915794.1 Mitochondrial ribonuclease P protein 3 KIAA0391;MRPP3 O15091-1;O15091;O15091-2;O15091-4 ENST00000250377 4 0.77084 1.662 0.77395 1.0377 1.07 0.99687 fn3;Y_phosphatase adherens junction;cell junction;cell-substrate adherens junction;cell-substrate junction;focal adhesion;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;phosphoprotein phosphatase activity;protein binding;protein tyrosine phosphatase activity;receptor activity;signal transducer activity;transmembrane receptor activity;transmembrane receptor protein tyrosine phosphatase activity cell activation;negative regulation of leukocyte mediated cytotoxicity;negative regulation of T cell mediated cytotoxicity;regulation of leukocyte mediated cytotoxicity;regulation of T cell mediated cytotoxicity Cell adhesion molecules (CAMs);Primary immunodeficiency;T cell receptor signaling pathway 32 32 32 29.7 29.7 29.7 147.25 0 1323000000 674780000 648190000 5291 IPI:IPI00844079.1;IPI:IPI00647613.4 Leukocyte common antigen;T200 PTPRC;CD45 P08575-1;P08575;P08575-2 ENST00000271610;ENST00000348564;ENST00000367372;ENST00000367376 K06478 2 1.0495 1.8077 1.074 1.3473 1.191 1.4284 C1-set;MHC_I;MHC_I_C cell part;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;macromolecular complex;membrane part;MHC class I protein complex;MHC protein complex;plasma membrane part;protein complex binding;MHC class I receptor activity;molecular transducer activity;protein binding;receptor activity;signal transducer activity;transmembrane receptor activity antigen processing and presentation;antigen processing and presentation of peptide antigen;antigen processing and presentation of peptide antigen via MHC class I;immune response;immune system process;interspecies interaction between organisms Allograft rejection;Antigen processing and presentation;Autoimmune thyroid disease;Cell adhesion molecules (CAMs);Graft-versus-host disease;Natural killer cell mediated cytotoxicity;Type I diabetes mellitus 17 17 6 52.6 52.6 10.7 40.84 0 724820000 348460000 376360000 5292 IPI:IPI00647634.1;IPI:IPI00472112.1;IPI:IPI00472448.1;IPI:IPI00026569.3;IPI:IPI00644748.19;IPI:IPI00742968.1;IPI:IPI00472736.1;IPI:IPI00004672.5 HLA class I histocompatibility antigen, A-3 alpha chain;MHC class I antigen A*3;HLA class I histocompatibility antigen, A-11 alpha chain;MHC class I antigen A*11;HLA class I histocompatibility antigen, A-1 alpha chain;MHC class I antigen A*1;HLA class I histocompatibility antigen, A-36 alpha chain;MHC class I antigen A*36;Aw-36 HLA-A;HLAA P04439;P13746-2;P13746;P13746-1;P30443;P30455 ENST00000376805;ENST00000376809;ENST00000396634;ENST00000383498;ENST00000400653 K06751 8 0.74331 NaN 0.84854 0.99044 NaN 1.0561 ABC1 cell part;integral to membrane;intrinsic to membrane;membrane part catalytic activity;kinase activity;phosphotransferase activity, alcohol group as acceptor;protein kinase activity;protein serine/threonine kinase activity;transferase activity;transferase activity, transferring phosphorus-containing groups 4 4 4 7.5 7.5 7.5 60.069 0.00017399 2503000 1309500 1193400 5293 IPI:IPI00647707.3;IPI:IPI00178315.2;IPI:IPI00464978.1 Uncharacterized aarF domain-containing protein kinase 4 ADCK4 Q96D53-1;Q96D53;Q96D53-2 ENST00000243583;ENST00000324464 K08869 3 0.86832 1.5418 0.98735 1.1781 1.0628 1.2665 ARD cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;nucleus;organelle;plasma membrane binding;catalytic activity;nickel ion binding;oxidoreductase activity;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen;protein binding cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;methionine metabolic process;organic acid metabolic process;sulfur amino acid biosynthetic process;sulfur amino acid metabolic process;sulfur metabolic process Methionine metabolism 10 10 10 65.4 65.4 65.4 21.498 4.8616E-96 810880000 397420000 413460000 5294 IPI:IPI00651738.1;IPI:IPI00470791.2 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase;Aci-reductone dioxygenase;Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1;Submergence-induced protein 2 homolog ADI1;MTCBP1;HMFT1638 Q9BV57-1;Q9BV57;Q9BV57-2 ENST00000327435;ENST00000382093 K08967 2 NaN 1.1287 NaN NaN 0.76944 NaN AhpC-TSA cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;oxidoreductase activity, acting on sulfur group of donors;oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor cell communication;cell differentiation;cell surface receptor linked signal transduction;cellular homeostasis;cellular process;metabolic process;multicellular organismal development;signal transduction;Wnt receptor signaling pathway 4 1 1 22 4 4 20.328 1.5636E-84 325440 178490 146950 5295 IPI:IPI00651743.1 Nucleoredoxin NXN;NRX Q6DKJ4-2;Q6DKJ4 ENST00000336868;ENST00000397383 1 0.66992 1.3198 0.6475 0.84602 0.9041 0.80951 Nol1_Nop2_Fmu;P120R cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;catalytic activity;methyltransferase activity;nucleic acid binding;protein binding;RNA binding;S-adenosylmethionine-dependent methyltransferase activity;transferase activity;transferase activity, transferring one-carbon groups cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;positive regulation of cell proliferation;RNA metabolic process;RNA processing;rRNA processing 18 18 18 23.9 23.9 23.9 92.859 2.7845E-204 1461700000 811090000 650640000 5296 IPI:IPI00654555.3;IPI:IPI00872909.1 Putative ribosomal RNA methyltransferase NOP2;Nucleolar protein 2 homolog;Nucleolar protein 1;Proliferating-cell nucleolar antigen p120;Proliferation-associated nucleolar protein p120 NOP2;NOL1 P46087-1;P46087;P46087-2 ENST00000322166;ENST00000399466 2 0.67732 1.2071 0.73874 0.89687 0.7527 0.96781 MAP7 cell part;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;organelle;organelle part;spindle 13 13 13 19.3 19.3 19.3 92.819 2.1646E-161 201400000 108110000 93285000 5297 IPI:IPI00654605.1;IPI:IPI00867630.1;IPI:IPI00645814.1;IPI:IPI00167009.3 MAP7 domain-containing protein 1;Proline/arginine-rich coiled-coil domain-containing protein 1;Arginine/proline-rich coiled-coil domain-containing protein 1 MAP7D1;KIAA1187;PARCC1;RPRC1;PP2464 Q3KQU3-1;Q3KQU3;Q3KQU3-4;Q3KQU3-2 ENST00000316156;ENST00000373148;ENST00000373151 4 0.76909 1.5518 0.79906 1.019 0.99468 1.16 MRP-S33 cytoplasmic part;intracellular part;macromolecular complex;mitochondrial part;mitochondrial small ribosomal subunit;organellar small ribosomal subunit;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 3 3 3 24.1 24.1 24.1 13.371 2.3866E-06 110310000 59201000 51106000 5298 IPI:IPI00654654.19 28S ribosomal protein S33, mitochondrial;MRP-S33 MRPS33;CGI-139;PTD003 Q9Y291 ENST00000324787;ENST00000393008;ENST00000393011 1 0.7739 1.3347 0.82353 0.98918 0.92716 1.0489 ATP-synt_A integral to membrane;intrinsic to membrane;macromolecular complex;mitochondrial proton-transporting ATP synthase complex, coupling factor F(o);organelle part;protein complex;proton-transporting two-sector ATPase complex, proton-transporting domain cation transmembrane transporter activity;hydrogen ion transmembrane transporter activity;ion transmembrane transporter activity;monovalent inorganic cation transmembrane transporter activity;transmembrane transporter activity;transporter activity ATP biosynthetic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;transport 2 2 2 6.8 6.8 6.8 26.049 2.3431E-06 411150000 226000000 185150000 5301 IPI:IPI00654820.2 ATP synthase subunit a;F-ATPase protein 6 MT-ATP6;ATP6;ATPASE6;MTATP6 P00846 ENST00000361899;ENST00000409008;ENST00000409152 1 0.7561 1.3295 0.77039 0.92055 0.91512 0.9482 Ribosomal_S26e cell part;cytoplasmic part;cytosolic part;cytosolic small ribosomal subunit;intracellular organelle part;intracellular part;macromolecular complex;organelle;organelle part;ribonucleoprotein complex;ribosomal subunit;ribosome;small ribosomal subunit binding;mRNA binding;nucleic acid binding;protein binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;negative regulation of macromolecule metabolic process;negative regulation of metabolic process;regulation of gene expression;translational elongation Ribosome 4 4 4 31.3 31.3 31.3 13.015 2.3711E-105 2077300000 1090500000 986790000 5302 IPI:IPI00655650.2;IPI:IPI00187140.1 40S ribosomal protein S26;Putative 40S ribosomal protein S26-like 1 RPS26;RPS26P11;RPS26L1 P62854;Q5JNZ5 ENST00000356247;ENST00000356464;ENST00000356756 K02976 2 0.75965 1.1294 0.78026 0.95323 0.779 0.99084 Tyr-DNA_phospho cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;DNA binding;double-stranded DNA binding;exonuclease activity;hydrolase activity;nuclease activity;nucleic acid binding;phosphoric diester hydrolase activity;protein binding;single-stranded DNA binding DNA metabolic process;DNA repair;double-strand break repair;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to DNA damage stimulus;response to stress;single strand break repair 5 5 5 11.3 11.3 11.3 68.42 4.6305E-45 8912200 4400700 4511500 5303 IPI:IPI00655885.2 Tyrosyl-DNA phosphodiesterase 1 TDP1 Q9NUW8 ENST00000335725;ENST00000393454 K10862 1 NaN 1.2945 NaN NaN 0.88672 NaN CXC cell part;chromosome;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 2 2 2 3.2 3.2 3.2 79.466 0.00086306 645150 308410 336740 5304 IPI:IPI00789941.2;IPI:IPI00655989.2;IPI:IPI00889131.1;IPI:IPI00900329.1 Protein lin-54 homolog;CXC domain-containing protein 1 LIN54;CXCDC1;KIAA2037 Q6MZP7-1;Q6MZP7;Q6MZP7-2;Q6MZP7-3;Q6MZP7-4 ENST00000340417;ENST00000395282;ENST00000395283 4 1.0061 1.7539 0.99709 1.207 1.1433 1.3194 PBD;Pkinase adherens junction;cell junction;cell-substrate adherens junction;cell-substrate junction;focal adhesion;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane part;membrane-bounded organelle;organelle ATP binding;binding;catalytic activity;collagen binding;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity apoptosis;ER-nuclear signaling pathway;organelle organization;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;regulation of protein amino acid phosphorylation Axon guidance;Chemokine signaling pathway;Epithelial cell signaling in Helicobacter pylori infection;ErbB signaling pathway;Focal adhesion;MAPK signaling pathway;MAPK signaling pathway - yeast;Natural killer cell mediated cytotoxicity;Regulation of actin cytoskeleton;Renal cell carcinoma;T cell receptor signaling pathway 14 7 6 27.9 15 13.4 60.646 1.0949E-283 82987000 41743000 41244000 5306 IPI:IPI00656138.1;IPI:IPI00289746.2 Serine/threonine-protein kinase PAK 1;p21-activated kinase 1;p65-PAK;Alpha-PAK PAK1 Q13153-1;Q13153;Q13153-2 ENST00000278568;ENST00000356341 K04409 2 0.79779 1.4377 0.76276 1.0885 0.95865 1.0267 XRN_N cell part;cytoplasm;intracellular part 5'-3' exonuclease activity;binding;catalytic activity;DNA binding;exonuclease activity;hydrolase activity;hydrolase activity, acting on ester bonds;nuclease activity;nucleic acid binding;protein binding;RNA binding cell cycle;cellular metabolic process;cellular process;metabolic process;negative regulation of cell cycle;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;primary metabolic process 10 10 10 7.7 7.7 7.7 194.1 2.2135E-17 20808000 11487000 9321000 5307 IPI:IPI00657805.1;IPI:IPI00657645.1;IPI:IPI00328115.3 5'-3' exoribonuclease 1;Strand-exchange protein 1 homolog XRN1;SEP1 Q8IZH2-1;Q8IZH2;Q8IZH2-2 ENST00000264951;ENST00000392981 3 1.6884 3.3486 1.9442 2.174 2.2371 2.503 MBOAT cell part;integral to membrane;intrinsic to membrane;membrane part acyltransferase activity;catalytic activity;transferase activity;transferase activity, transferring acyl groups;transferase activity, transferring acyl groups other than amino-acyl groups biosynthetic process;cellular metabolic process;cellular process;lipid biosynthetic process;lipid metabolic process;metabolic process;organophosphate metabolic process;phospholipid biosynthetic process;phospholipid metabolic process 5 5 5 14.6 14.6 14.6 52.764 3.1553E-68 83435000 39580000 43854000 5308 IPI:IPI00657706.1;IPI:IPI00885058.1;IPI:IPI00645667.1 Lysophospholipid acyltransferase 7;1-acylglycerophosphatidylinositol O-acyltransferase;Lysophosphatidylinositol acyltransferase;Leukocyte receptor cluster member 4;Bladder and breast carcinoma-overexpressed gene 1 protein;Membrane-bound O-acyltransferase domain-containing protein 7 MBOAT7;BB1;LENG4;OACT7 Q96N66-1;Q96N66;Q96N66-2;Q96N66-3 ENST00000245615 3 0.37125 0.80158 NaN 0.47021 0.58409 NaN zf-4CXXC_R1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 4 4 3 9 9 7 52.206 1.0136E-16 38141000 19609000 18532000 5310 IPI:IPI00657791.2;IPI:IPI00784657.1 Cell division cycle-associated 7-like protein;Protein JPO2;Transcription factor RAM2 CDCA7L;HR1;JPO2;R1 Q96GN5-1;Q96GN5;Q96GN5-2 ENST00000373934;ENST00000406877 2 0.94385 1.6355 0.99988 1.2184 1.1146 1.2492 Septin cell cortex part;cell part;cytoplasmic part;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;organelle part;protein complex;septin complex binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;protein binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cell cycle;cell division;cellular process 13 13 13 46.3 46.3 46.3 41.97 2.7946E-252 1465900000 637430000 828420000 5311 IPI:IPI00657797.3;IPI:IPI00910257.1 Septin-1;LARP;Serologically defined breast cancer antigen NY-BR-24;Peanut-like protein 3 SEPT1;DIFF6;PNUTL3 Q8WYJ6-1;Q8WYJ6 ENST00000321367;ENST00000395109 2 0.60822 0.79133 0.86158 0.75317 0.54479 1.0908 DUF2216 3 3 3 7.6 7.6 7.6 45.209 0.0015293 15324000 9075600 6248800 5312 IPI:IPI00657798.2 Coiled-coil domain-containing protein 85C CCDC85C A6NKD9 ENST00000380243 1 0.71942 1.5004 0.67573 0.97452 0.97439 0.93506 KH_1;RRM_1 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;mRNA 5'-UTR binding;mRNA binding;nucleic acid binding;nucleotide binding;RNA binding;translation regulator activity anatomical structure morphogenesis;biosynthetic process;macromolecule biosynthetic process;metabolic process;regulation of biosynthetic process;regulation of cytokine production;regulation of translation;translation 20 20 18 39.4 39.4 36.1 63.704 1.5738E-174 521600000 283850000 237740000 5313 IPI:IPI00658000.3;IPI:IPI00165467.10 Insulin-like growth factor 2 mRNA-binding protein 3;IGF-II mRNA-binding protein 3;KH domain-containing protein overexpressed in cancer;VICKZ family member 3 IGF2BP3;IMP3;KOC1;VICKZ3 O00425-1;O00425 ENST00000258729 2 0.9037 1.5962 0.85259 1.1467 1.0727 1.0519 SH2;Y_phosphatase cell part;cytoplasmic part;cytosol;intracellular part binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;non-membrane spanning protein tyrosine phosphatase activity;phosphoprotein phosphatase activity;protein binding;protein tyrosine phosphatase activity cell communication;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid dephosphorylation;protein modification process;sensory perception;sensory perception of sound;signal transduction;system process Adipocytokine signaling pathway;Chronic myeloid leukemia;Epithelial cell signaling in Helicobacter pylori infection;Jak-STAT signaling pathway;Leukocyte transendothelial migration;MAPK signaling pathway - fly;Natural killer cell mediated cytotoxicity;Renal cell carcinoma 18 18 18 37.2 37.2 37.2 68.436 3.6222E-146 397120000 207320000 189800000 5314 IPI:IPI00658023.1;IPI:IPI00298347.1;IPI:IPI00658002.1 Tyrosine-protein phosphatase non-receptor type 11;Protein-tyrosine phosphatase 2C;PTP-1D;SH-PTP3;SH-PTP2 PTPN11;PTP2C;SHPTP2 Q06124-1;Q06124;Q06124-2;Q06124-3 ENST00000351677;ENST00000392596 K07293 3 0.22803 0.46535 0.23096 0.28503 0.32747 0.29168 HEAT extracellular region binding 12 12 12 20 20 20 88.118 1.6414E-168 61890000 39468000 22422000 5315 IPI:IPI00658145.3;IPI:IPI00797616.1;IPI:IPI00798399.2 HEAT repeat-containing protein C7orf27 C7orf27 Q6PJG6-1;Q6PJG6 ENST00000340611 3 0.74852 1.8204 0.85992 0.98808 1.2019 1.057 WD40 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;lysosome;lytic vacuole;membrane-bounded organelle;nucleus;organelle;vacuole binding;protein binding biopolymer metabolic process;biopolymer modification;cellular biopolymer metabolic process;cellular process;macromolecule metabolic process;metabolic process;protein deubiquitination;protein metabolic process;protein modification process 4 4 4 9 9 9 76.21 9.4274E-41 23457000 7889100 15567000 5316 IPI:IPI00658210.1;IPI:IPI00937128.1;IPI:IPI00792902.2;IPI:IPI00791758.3;IPI:IPI00658079.1 WD repeat-containing protein 48;WD repeat endosomal protein;USP1-associated factor 1;p80 WDR48;KIAA1449;UAF1 Q8TAF3-1;Q8TAF3;Q8TAF3-3;Q8TAF3-4;Q8TAF3-5 ENST00000302313;ENST00000396258 5 0.39779 1.1167 NaN 0.53282 0.70647 NaN Diphthamide_syn cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle biosynthetic process;cell cycle;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation 4 4 4 9.3 9.3 9.3 48.805 3.7818E-44 3901200 2284300 1616900 5318 IPI:IPI00718991.4;IPI:IPI00868806.1;IPI:IPI00868847.1 Diphthamide biosynthesis protein 1;DPH1 homolog;Diphthamide biosynthesis protein 2 homolog-like 1;Ovarian cancer-associated gene 1 protein DPH1;DPH2L;DPH2L1;OVCA1 Q9BZG8-1;Q9BZG8;Q9BZG8-2;Q9BZG8-3 ENST00000263083 3 0.46008 1.0025 0.46916 0.6091 0.62348 0.59832 centrosome;cytoplasmic part;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;microtubule organizing center;non-membrane-bounded organelle;organelle;organelle part;spindle cell cycle phase;cell cycle process;cell division;cellular component organization;cellular process;mitosis;nuclear division;organelle fission;organelle organization 13 13 13 14.2 14.2 14.2 108.62 2.2293E-89 134920000 112600000 22325000 5320 IPI:IPI00719210.1;IPI:IPI00465253.4 HAUS augmin-like complex subunit 6 HAUS6;DGT6;FAM29A;KIAA1574 Q7Z4H7-1;Q7Z4H7;Q7Z4H7-2 ENST00000380502 2 0.66185 1.2293 0.68182 0.83346 0.86485 0.86535 FragX_IP cell fraction;cell junction;cell part;cytoplasmic part;insoluble fraction;intracellular part;membrane fraction;membrane part;perinuclear region of cytoplasm;plasma membrane part;synapse;synaptosome binding;protein binding apoptosis;biological adhesion;cell adhesion;cell death;cell-cell adhesion;cellular process;death;programmed cell death Regulation of actin cytoskeleton 28 28 18 26.1 26.1 17.2 145.67 1.2936E-240 444680000 241030000 203650000 5321 IPI:IPI00719600.5;IPI:IPI00789699.2 Cytoplasmic FMR1-interacting protein 2;p53-inducible protein 121 CYFIP2;KIAA1168;PIR121 Q96F07-2;Q96F07;Q96F07-1 ENST00000318218;ENST00000347377;ENST00000377576 K05749 2 0.70131 1.2097 0.74149 0.95711 0.83848 0.95371 Ribosomal_S28e cell part;cytoplasmic part;cytosolic part;cytosolic small ribosomal subunit;intracellular organelle part;intracellular part;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit binding;protein binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA processing;rRNA processing;translational elongation Ribosome 7 7 7 60.9 60.9 60.9 7.8409 7.1166E-69 1843700000 954900000 888760000 5322 IPI:IPI00719622.1 40S ribosomal protein S28 RPS28 P62857 K02979 1 0.86179 1.8041 0.84711 1.1405 1.1757 1.166 TPR_1;TPR_2 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle;perinuclear region of cytoplasm binding;protein binding anatomical structure development;cell differentiation;cellular developmental process;cellular process;developmental process;muscle organ development;organ development 25 25 1 29.2 29.2 1.1 101.67 0 301650000 161540000 140120000 5323 IPI:IPI00735181.2 Protein unc-45 homolog A;GCUNC-45;Smooth muscle cell-associated protein 1 UNC45A;SMAP1 Q9H3U1-2;Q9H3U1 ENST00000268159;ENST00000394275 1 0.65733 1.518 0.69544 0.88983 1.0867 0.93843 PP2C catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;phosphatase activity;phosphoprotein phosphatase activity;phosphoric ester hydrolase activity 5 5 5 13.8 13.8 13.8 56.447 8.4518E-66 9778000 4789000 4989000 5324 IPI:IPI00736251.2 Protein phosphatase 1H PPM1H;ARHCL1;KIAA1157 Q9ULR3 ENST00000228705 1 NaN 1.5091 NaN NaN 1.0261 NaN 2 2 2 5.2 5.2 5.2 74.954 0.0021892 745970 432900 313070 5326 IPI:IPI00737638.2 UPF0611 protein FAM169A FAM169A;KIAA0888 Q9Y6X4-1;Q9Y6X4 ENST00000380515;ENST00000389156 1 0.60386 1.0852 0.62792 0.74969 0.77976 0.77373 3 3 3 1.9 1.9 1.9 247.89 3.129E-06 77280000 41969000 35311000 5327 IPI:IPI00738216.2 Uncharacterized protein KIAA0947 KIAA0947 Q9Y2F5 ENST00000296564 1 0.41085 0.88201 0.45679 0.55422 0.60216 0.58445 C1_4;Ssl1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;nuclear part;nucleoplasm;nucleus;organelle;organelle part binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transcription factor activity;transition metal ion binding;translation factor activity, nucleic acid binding;zinc ion binding DNA metabolic process;DNA repair;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;response to DNA damage stimulus;response to stress;transcription Basal transcription factors;Nucleotide excision repair 5 5 5 16.5 16.5 16.5 44.452 1.197E-18 38179000 21657000 16523000 5328 IPI:IPI00738524.1;IPI:IPI00426640.1 General transcription factor IIH subunit 2-like protein;General transcription factor IIH polypeptide 2-like protein;General transcription factor IIH subunit 2;General transcription factor IIH polypeptide 2;TFIIH basal transcription factor complex p44 subunit;Basic transcription factor 2 44 kDa subunit;BTF2-p44 GTF2H2;BTF2P44 Q6P1K8;Q13888 ENST00000380729;ENST00000274400;ENST00000330280 K03142 2 0.8494 2.1343 0.65149 1.1112 1.3758 0.80819 cell fraction;cell part;insoluble fraction binding;PDZ domain binding;protein binding;protein domain specific binding;protein self-association cell communication;cell surface receptor linked signal transduction;cellular process;metabolic process;protein complex assembly;regulation of gene expression;regulation of protein amino acid phosphorylation;signal transduction 5 5 5 3 3 3 228.21 4.2986E-08 51058000 26559000 24499000 5329 IPI:IPI00740019.2 Protein Daple;Dvl-associating protein with a high frequency of leucine residues;Coiled-coil domain-containing protein 88C;Hook-related protein 2 CCDC88C;DAPLE;KIAA1509 Q9P219-1;Q9P219 ENST00000389857 1 NaN 1.3725 NaN NaN 0.87794 NaN BEN 3 3 3 4.1 4.1 4.1 94.474 2.6357E-38 1911300 1084300 826990 5331 IPI:IPI00741958.1 BEN domain-containing protein 3 BEND3;KIAA1553 Q5T5X7 ENST00000339644;ENST00000369042 1 0.81231 1.3813 0.84001 1.0761 0.94998 1.0751 UBX binding;protein binding 7 7 7 18.8 18.8 18.8 54.862 3.8311E-89 121980000 63955000 58021000 5332 IPI:IPI00742124.2 UBX domain-containing protein 7 UBXN7;KIAA0794;UBXD7 O94888 ENST00000296328;ENST00000381887 1 0.71967 1.4662 0.73701 0.99978 0.95346 0.99654 TPR_MLP1_2 cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;membrane;membrane part;nuclear membrane;nuclear part;nuclear pore;nucleoplasm;organelle membrane;organelle part;pore complex;protein complex aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-oxygen bonds;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;serine-tRNA ligase activity cell cycle checkpoint;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;seryl-tRNA aminoacylation;tRNA aminoacylation for protein translation;tRNA metabolic process MAPK signaling pathway - yeast;Pathways in cancer;Thyroid cancer 55 55 55 28.2 28.2 28.2 267.29 0 1345500000 715550000 629930000 5333 IPI:IPI00742682.2 Nucleoprotein TPR TPR P12270 ENST00000367478 K09291 1 0.69696 1.4249 0.74019 0.92173 0.94302 0.93893 13 13 13 23.9 23.9 23.9 73.451 2.477E-86 377320000 213280000 164040000 5334 IPI:IPI00742863.2;IPI:IPI00943662.1;IPI:IPI00643888.2 Uncharacterized protein C6orf190 C6orf190;C6orf207 Q8N1K5-1;Q8N1K5;Q8N1K5-2;Q8N1K5-3 ENST00000368248 3 0.73647 1.3201 0.78961 0.94183 0.9147 0.96282 WD40 cell part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;organelle part;pore complex;protein complex cellular process;establishment of protein localization;intracellular protein transport;intracellular transport;mRNA transport;nucleic acid transport;nucleobase, nucleoside, nucleotide and nucleic acid transport;protein transport;RNA transport;transport 6 6 6 23.7 23.7 23.7 42.15 1.3361E-170 277600000 147660000 129940000 5335 IPI:IPI00742943.1 Nucleoporin Nup43;p42 NUP43 Q8NFH3 ENST00000340413;ENST00000367404;ENST00000403890 1 0.63406 1.5189 NaN 0.85648 1.0045 NaN binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding 7 7 7 12.9 12.9 12.9 77.667 1.9511E-152 41435000 22899000 18537000 5336 IPI:IPI00742996.2 RING finger protein 214 RNF214 Q8ND24 ENST00000300650;ENST00000397945 1 0.30526 0.64427 NaN 0.39849 0.43854 NaN B12-binding;B12-binding_2;Met_synt_B12;Pterin_bind;S-methyl_trans cell part;cytoplasmic part;cytosol;intracellular part binding;catalytic activity;dihydropteroate synthase activity;methionine synthase activity;methyltransferase activity;protein binding;S-adenosylmethionine-dependent methyltransferase activity;S-methyltransferase activity;zinc ion binding cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;methionine metabolic process;organic acid metabolic process;sulfur amino acid biosynthetic process;sulfur amino acid metabolic process Methionine metabolism;One carbon pool by folate 4 4 4 3.8 3.8 3.8 140.53 5.4036E-18 16078000 11825000 4252700 5337 IPI:IPI00743284.2 Methionine synthase;5-methyltetrahydrofolate--homocysteine methyltransferase;Vitamin-B12 dependent methionine synthase MTR Q99707 ENST00000366576 K00548 1 1.1053 2.0443 0.96811 1.4893 1.3018 1.3454 LIM adherens junction;cell junction;cell-substrate adherens junction;cell-substrate junction;cytoplasm;cytoskeleton;focal adhesion;intracellular organelle;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle binding;nuclear hormone receptor binding;protein binding;receptor binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding;transcription regulator activity;zinc ion binding cell communication;intracellular signaling cascade;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;signal transduction;transcription 8 8 8 30.8 30.8 30.8 32.193 3.6794E-54 46115000 23658000 22457000 5338 IPI:IPI00743342.2 Four and a half LIM domains protein 2;Skeletal muscle LIM-protein 3;LIM domain protein DRAL FHL2;DRAL;SLIM3 Q14192 ENST00000322142;ENST00000344213;ENST00000358129;ENST00000393352;ENST00000393353;ENST00000408995;ENST00000409177;ENST00000409807 1 1.4634 2.7046 2.6215 2.0477 1.7569 3.6802 CALCOCO1 cell fraction;cytoskeleton;Golgi apparatus;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle;soluble fraction binding;identical protein binding;protein binding;protein dimerization activity;protein homodimerization activity response to chemical stimulus;response to cytokine stimulus;response to interferon-gamma;response to organic substance;response to stimulus;viral reproduction 8 8 8 26.9 26.9 26.9 52.253 8.0316E-75 38553000 14142000 24411000 5339 IPI:IPI00743360.2 Calcium-binding and coiled-coil domain-containing protein 2;Nuclear domain 10 protein NDP52;Antigen nuclear dot 52 kDa protein CALCOCO2;NDP52 Q13137 ENST00000258947 1 NaN 1.5948 0.9263 NaN 1.1143 1.2151 V_ATPase_I cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;cytoplasmic vesicle membrane;integral to membrane;intrinsic to membrane;macromolecular complex;membrane;membrane-bounded vesicle;organelle membrane;vesicle;vesicle membrane binding;cation transmembrane transporter activity;hydrogen ion transmembrane transporter activity;ion transmembrane transporter activity;monovalent inorganic cation transmembrane transporter activity;protein binding;transporter activity ATP biosynthetic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;transport 4 4 4 5.4 5.4 5.4 96.412 4.4904E-11 7263300 3729200 3534000 5341 IPI:IPI00796045.5;IPI:IPI00743576.1 V-type proton ATPase 116 kDa subunit a isoform 1;Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1;Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit;Vacuolar proton pump subunit 1;Vacuolar adenosine triphosphatase subunit Ac116 ATP6V0A1;ATP6N1;ATP6N1A;VPP1 Q93050-2;Q93050;Q93050-1 ENST00000264649;ENST00000343619;ENST00000393829 2 0.93058 0.89542 NaN 1.1572 0.58957 NaN MATH;zf-C3HC4;zf-TRAF cell part;cytoplasmic part;cytosol;intracellular part acid-amino acid ligase activity;binding;catalytic activity;ion binding;ligase activity;ligase activity, forming carbon-nitrogen bonds;protein binding;small conjugating protein ligase activity;ubiquitin-protein ligase activity;zinc ion binding activation of immune response;immune response-activating cell surface receptor signaling pathway;immune system process;positive regulation of cytokine production;protein polyubiquitination;regulation of cytokine production MAPK signaling pathway;Pathways in cancer;Small cell lung cancer;Toll-like receptor signaling pathway;Ubiquitin mediated proteolysis 2 2 2 4 4 4 59.573 0.00058792 3284700 1646600 1638100 5342 IPI:IPI00743663.3 TNF receptor-associated factor 6;Interleukin-1 signal transducer;RING finger protein 85 TRAF6;RNF85 Q9Y4K3 ENST00000313105;ENST00000348124 K03175 1 0.59632 NaN NaN 0.80078 NaN NaN CH;IQ cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;calmodulin binding;protein binding cell cycle phase;cell cycle process;cell division;cellular component organization;cellular process;mitosis;nuclear division;organelle fission;organelle organization 5 5 5 1.4 1.4 1.4 409.8 3.3579E-60 3788800 2136500 1652300 5344 IPI:IPI00743813.3;IPI:IPI00480042.3 Abnormal spindle-like microcephaly-associated protein;Abnormal spindle protein homolog ASPM;MCPH5 Q8IZT6-1;Q8IZT6;Q8IZT6-2 ENST00000294732;ENST00000367409 2 0.89974 1.7239 0.98102 1.1325 1.1469 1.2164 WD40 cell part;cytoplasmic part;cytosol;intracellular part;macromolecular complex;protein complex binding;protein binding interspecies interaction between organisms;multi-organism process 8 8 8 23.7 23.7 23.7 42.19 4.1774E-95 445470000 88420000 357050000 5345 IPI:IPI00743862.2;IPI:IPI00867542.1 Proteasomal ATPase-associated factor 1;WD repeat-containing protein 71;Protein G-16 PAAF1;WDR71 Q9BRP4-1;Q9BRP4;Q9BRP4-2 ENST00000310571;ENST00000376384 K11887 2 1.1621 1.7584 0.87631 1.4595 1.1677 1.1703 GRASP55_65 cell part;cytoplasmic part;Golgi apparatus part;Golgi membrane;intracellular organelle part;intracellular part;membrane;organelle membrane;organelle part binding;protein binding 8 8 8 28 28 28 48.674 5.151E-142 231790000 114990000 116800000 5346 IPI:IPI00743931.3;IPI:IPI00941614.1 Golgi reassembly-stacking protein 2;Golgi reassembly-stacking protein of 55 kDa;p59;Golgi phosphoprotein 6 GORASP2 Q9H8Y8-2;Q9H8Y8;Q9H8Y8-1 ENST00000234160 2 0.6897 1.5144 0.29765 0.91286 0.98567 0.43472 Biotin_carb_C;Biotin_lipoyl;CPSase_L_chain;CPSase_L_D2 cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part ATP binding;binding;biotin binding;catalytic activity;CoA carboxylase activity;ligase activity;ligase activity, forming carbon-carbon bonds;nucleoside binding;nucleotide binding;propionyl-CoA carboxylase activity;purine nucleoside binding metabolic process 14 14 14 22.4 22.4 22.4 80.058 1.6083E-74 27766000 15060000 12706000 5347 IPI:IPI00744115.1 Propionyl-CoA carboxylase alpha chain, mitochondrial;Propanoyl-CoA:carbon dioxide ligase subunit alpha PCCA P05165 ENST00000376285;ENST00000376286 1 0.72452 0.99584 0.97356 0.96102 0.64756 1.183 IF4E cell part;cytoplasm;intracellular part binding;nucleic acid binding;protein binding;RNA binding;RNA cap binding;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity cellular process;posttranscriptional regulation of gene expression;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of translation;translational initiation Insulin signaling pathway;mTOR signaling pathway 4 4 4 20.4 20.4 20.4 28.362 1.218E-07 13201000 4553700 8647000 5349 IPI:IPI00744211.2 Eukaryotic translation initiation factor 4E type 2;mRNA cap-binding protein type 3;Eukaryotic translation initiation factor 4E-like 3;Eukaryotic translation initiation factor 4E homologous protein;mRNA cap-binding protein 4EHP;eIF4E-like protein 4E-LP EIF4E2;EIF4EL3 O60573 ENST00000258416 K03259 1 0.94526 1.8352 0.75517 1.1717 1.298 0.95692 Rap_GAP cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;nucleus;organelle enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity biological regulation;regulation of biological process;regulation of cell communication;regulation of cellular process;regulation of signal transduction;regulation of small GTPase mediated signal transduction 5 5 5 2.4 2.4 2.4 221.1 1.3949E-12 12629000 6549400 6079100 5350 IPI:IPI00744251.2;IPI:IPI00456722.3;IPI:IPI00472044.3;IPI:IPI00456723.1;IPI:IPI00646904.3 GTPase-activating Rap/Ran-GAP domain-like 1;GAP-related-interacting partner to E12;Tuberin-like protein 1 GARNL1;KIAA0884;TULIP1 Q6GYQ0-4;Q6GYQ0;Q6GYQ0-2;Q6GYQ0-1;Q6GYQ0-5 ENST00000258840;ENST00000307138;ENST00000335518;ENST00000382366;ENST00000389698 5 0.84689 1.6233 0.78102 1.114 1.0624 1.0353 Alpha_adaptinC2;GAT;VHS AP-type membrane coat adaptor complex;clathrin adaptor complex;cytoplasmic part;endosomal part;endosome membrane;Golgi apparatus part;intracellular part;macromolecular complex;membrane;membrane part;organelle membrane;organelle part;protein complex binding;protein binding cellular process;establishment of localization;establishment of localization in cell;establishment of protein localization;intracellular protein transport;intracellular transport;protein transport;transport;vesicle-mediated transport 6 6 5 9.4 9.4 8.3 70.383 3.0112E-21 89300000 47467000 41833000 5351 IPI:IPI00744361.1;IPI:IPI00216337.1 ADP-ribosylation factor-binding protein GGA1;Golgi-localized, gamma ear-containing, ARF-binding protein 1;Gamma-adaptin-related protein 1 GGA1 Q9UJY5-1;Q9UJY5;Q9UJY5-2 ENST00000337437;ENST00000343632;ENST00000381756 K12404 2 0.83326 1.6215 0.84638 1.0885 1.0845 1.112 Pkinase cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;nucleus;organelle;plasma membrane ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cell communication;cell surface receptor linked signal transduction;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;signal transduction Adherens junction;Circadian rhythm - plant;Tight junction;Wnt signaling pathway 22 22 21 56.8 56.8 56.8 45.143 0 2824400000 1466900000 1357500000 5352 IPI:IPI00744507.1;IPI:IPI00877726.3;IPI:IPI00015141.4;IPI:IPI00658109.1 Casein kinase II subunit alpha CSNK2A1;CK2A1 P68400 ENST00000217244;ENST00000349736;ENST00000381973 K03097 4 0.8312 1.55 NaN 1.0396 1.0916 NaN Sugar_tr cell part;integral to membrane;intrinsic to membrane;membrane;membrane part;plasma membrane cation transmembrane transporter activity;cation:sugar symporter activity;glucose transmembrane transporter activity;ion transmembrane transporter activity;sugar:hydrogen symporter activity;transporter activity carbohydrate transport;cellular process;establishment of localization;transmembrane transport;transport 2 2 2 3.7 3.7 3.7 54.539 2.191E-13 3624300 1766100 1858200 5353 IPI:IPI00744602.2 Solute carrier family 2, facilitated glucose transporter member 6;Glucose transporter type 6;Glucose transporter type 9 SLC2A6;GLUT9 Q9UGQ3 ENST00000371899 K08144 1 0.89849 1.5826 0.89453 1.1288 1.0788 1.1251 FYVE;RUN cell part;cytoplasmic part;early endosome membrane;endosomal part;endosome membrane;intracellular organelle part;intracellular part;membrane;organelle membrane;organelle part binding;cation binding;ion binding;lipid binding;metal ion binding;transition metal ion binding;zinc ion binding cellular component organization;cellular process;endocytosis;establishment of localization;establishment of protein localization;membrane invagination;membrane organization;protein transport;transport;vesicle-mediated transport 17 17 16 30.8 30.8 29.7 79.817 0 216790000 109870000 106920000 5354 IPI:IPI00744637.2;IPI:IPI00465429.3;IPI:IPI00556586.2 RUN and FYVE domain-containing protein 1;FYVE-finger protein EIP1;Zinc finger FYVE domain-containing protein 12;La-binding protein 1;Rab4-interacting protein RUFY1;RABIP4;ZFYVE12 Q96T51-1;Q96T51;Q96T51-2 ENST00000377001;ENST00000393438;ENST00000393448 3 0.82501 1.6838 0.83576 1.0943 1.1161 1.0912 Transaldolase cell part;cytoplasmic part;cytosol;intracellular part binding;catalytic activity;protein binding;transaldolase activity;transferase activity;transferase activity, transferring aldehyde or ketonic groups alcohol metabolic process;carbohydrate metabolic process;glucose catabolic process;glucose metabolic process;monosaccharide metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;pentose-phosphate shunt Pentose phosphate pathway 22 22 22 52.2 52.2 52.2 37.54 3.6471E-270 6012100000 3189300000 2822700000 5355 IPI:IPI00744692.1 Transaldolase TALDO1;TAL;TALDO;TALDOR P37837 ENST00000319006 K00616 1 1.181 1.37 NaN 1.5071 0.8775 NaN DUF2464 centrosome;endosome membrane;intracellular membrane-bounded organelle;intracellular organelle;late endosome membrane;membrane;membrane-bounded organelle;microtubule organizing center;non-membrane-bounded organelle;nucleus;organelle;organelle membrane binding;protein binding;protein domain specific binding;SH3 domain binding establishment of localization;establishment of protein localization;protein transport;transport 3 3 3 16.5 16.5 16.5 28.783 3.5363E-79 3987900 1294300 2693600 5356 IPI:IPI00744702.2;IPI:IPI00788162.1;IPI:IPI00787031.1 Multivesicular body subunit 12A;ESCRT-I complex subunit MVB12A;Protein FAM125A;CIN85/CD2AP family-binding protein FAM125A;CFBP Q96EY5-1;Q96EY5;Q96EY5-3;Q96EY5-2 ENST00000317040;ENST00000392702 K12186 3 0.70556 1.4406 0.67532 0.94427 0.94371 0.90703 KH_1;PNPase;RNase_PH;RNase_PH_C 3'-5' exonuclease activity;3'-5'-exoribonuclease activity;binding;catalytic activity;exonuclease activity;exoribonuclease activity;nuclease activity;nucleic acid binding;polyribonucleotide nucleotidyltransferase activity;ribonuclease activity;RNA binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;mRNA catabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA catabolic process;RNA processing Purine metabolism;Pyrimidine metabolism 21 21 21 29.8 29.8 29.8 85.95 1.7329E-198 438260000 240630000 197630000 5357 IPI:IPI00744711.2 Polyribonucleotide nucleotidyltransferase 1, mitochondrial;PNPase 1;Polynucleotide phosphorylase-like protein;PNPase old-35;3'-5' RNA exonuclease OLD35 PNPT1;PNPASE Q8TCS8 ENST00000260604;ENST00000402246 K00962 1 0.71026 1.3647 0.72787 0.96397 0.88834 0.97111 Ribosomal_S17 cytoplasmic part;intracellular part;macromolecular complex;membrane;mitochondrial part;mitochondrial small ribosomal subunit;organellar small ribosomal subunit;organelle part;ribonucleoprotein complex;ribosomal subunit;small ribosomal subunit binding;nucleic acid binding;RNA binding;rRNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation;transport 3 3 3 22.3 22.3 22.3 14.502 3.38E-09 77359000 41498000 35861000 5358 IPI:IPI00744772.2 28S ribosomal protein S17, mitochondrial;MRP-S17 MRPS17;RPMS17;HSPC011 Q9Y2R5 ENST00000285298 1 0.92057 1.5292 0.94896 1.1367 1.1105 1.2113 DUF938 3 3 3 19.6 19.6 19.6 22.578 5.5514E-69 45175000 21877000 23298000 5359 IPI:IPI00745105.1;IPI:IPI00065475.6;IPI:IPI00893549.1 UPF0585 protein C16orf13 C16orf13;JFP2 Q96S19-1;Q96S19;Q96S19-2;Q96S19-3 ENST00000301686;ENST00000338401 3 0.72674 1.3643 0.68777 1.0052 0.89476 0.99511 MBOAT cell fraction;endoplasmic reticulum membrane;insoluble fraction;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane fraction;membrane part;microsome;organelle membrane;organelle part;vesicular fraction acyl-CoA binding;acyltransferase activity;binding;catalytic activity;cholesterol binding;fatty acid binding;lipid binding;O-acyltransferase activity;steroid binding;sterol O-acyltransferase activity;transferase activity alcohol metabolic process;biosynthetic process;cholesterol metabolic process;leukocyte differentiation;lipid metabolic process;lipid transport;metabolic process;myeloid leukocyte differentiation;steroid metabolic process;transport Biosynthesis of steroids 3 3 3 7.1 7.1 7.1 64.734 2.804E-21 112170000 59448000 52719000 5360 IPI:IPI00745125.2 Sterol O-acyltransferase 1;Cholesterol acyltransferase 1;Acyl coenzyme A:cholesterol acyltransferase 1 SOAT1;ACACT;ACACT1;ACAT;ACAT1;SOAT;STAT P35610 ENST00000367619 K00637 1 0.73619 1.5024 0.74198 0.97304 0.97541 0.97291 Paf67 cell part;cytoplasmic part;eukaryotic translation initiation factor 3 complex;intracellular part;macromolecular complex;protein complex binding;nucleic acid binding;protein binding;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity cellular process;translational initiation 26 26 26 45 45 45 66.726 0 2594400000 1386300000 1208100000 5361 IPI:IPI00745266.1 Eukaryotic translation initiation factor 3 subunit L;Eukaryotic translation initiation factor 3 subunit E-interacting protein;Eukaryotic translation initiation factor 3 subunit 6-interacting protein EIF3L;EIF3EIP;EIF3S6IP;HSPC021;HSPC025;MSTP005 Q9Y262 ENST00000262832;ENST00000381683 1 0.66378 1.2462 0.62816 0.82306 0.81582 0.83378 DUF1785;PAZ;Piwi cytoplasmic mRNA processing body;macromolecular complex;micro-ribonucleoprotein complex;mRNA cap binding complex;nucleus;organelle;ribonucleoprotein complex;RNA cap binding complex;RNAi effector complex;RNA-induced silencing complex binding;catalytic activity;endonuclease activity;endoribonuclease activity;nuclease activity;nucleic acid binding;protein binding;ribonuclease activity;RNA 7-methylguanosine cap binding;RNA binding;RNA cap binding;translation initiation factor activity mRNA cleavage;mRNA processing;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;regulation of translation;regulation of translational initiation;RNA processing;transcription;translation 9 9 6 14.9 14.9 10.5 97.207 3.2892E-73 45189000 25198000 19991000 5362 IPI:IPI00745433.2;IPI:IPI00929290.1;IPI:IPI00304181.4 Protein argonaute-2;Argonaute2;Protein slicer;PAZ Piwi domain protein;Eukaryotic translation initiation factor 2C 2 EIF2C2;AGO2 Q9UKV8-1;Q9UKV8;Q9UKV8-2 ENST00000220592 K11593 3 0.79524 1.5587 0.84775 1.072 1.009 1.0805 TIP41 binding;protein binding 14 14 14 55.9 55.9 55.9 31.444 4.3117E-268 706140000 370910000 335230000 5364 IPI:IPI00745568.2;IPI:IPI00641815.1 TIP41-like protein;Putative MAPK-activating protein PM10 TIPRL O75663-1;O75663;O75663-2 ENST00000367830;ENST00000367833;ENST00000401737 2 0.67945 1.1914 0.69601 0.81605 0.84927 0.85539 RNase_PH;RNase_PH_C cytoplasm;exosome (RNase complex);intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;protein complex 3'-5' exonuclease activity;3'-5'-exoribonuclease activity;binding;catalytic activity;exonuclease activity;exoribonuclease activity;hydrolase activity;nuclease activity;nucleic acid binding;protein binding;ribonuclease activity;RNA binding cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 5 5 5 22.4 22.4 22.4 26.383 3.1943E-23 154020000 76614000 77406000 5365 IPI:IPI00745613.2 Exosome complex exonuclease RRP41;Ribosomal RNA-processing protein 41;Exosome component 4;p12A EXOSC4;RRP41;SKI6 Q9NPD3 ENST00000316052 K01149 1 NaN NaN 0.79337 NaN NaN 1.0265 NmrA binding;catalytic activity;oxidoreductase activity;transcription regulator activity;transcription repressor activity biological regulation;metabolic process;oxidation reduction;regulation of biological process;regulation of metabolic process;regulation of nitrogen compound metabolic process;regulation of nitrogen utilization 2 2 2 5.7 5.7 5.7 37.051 1.5234E-18 12334000 7205500 5128800 5366 IPI:IPI00745792.1 NmrA-like family domain-containing protein 1 NMRAL1;HSCARG Q9HBL8 ENST00000283429;ENST00000404295 1 1.1201 1.8564 1.0957 1.4345 1.2386 1.3977 Cyclin_C;Cyclin_N centrosome;cytoplasmic part;cytoskeletal part;cytosol;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;microtubule organizing center;non-membrane-bounded organelle;nuclear part;nucleoplasm;organelle;organelle part binding;protein binding catabolic process;cellular process;G2/M transition of mitotic cell cycle;macromolecule catabolic process;metabolic process;mitosis;nuclear division;organelle organization;proteolysis;ubiquitin-dependent protein catabolic process Cell cycle;p53 signaling pathway;Progesterone-mediated oocyte maturation 7 7 7 19.4 19.4 19.4 48.337 6.6634E-121 265930000 128790000 137140000 5367 IPI:IPI00745793.1 G2/mitotic-specific cyclin-B1 CCNB1;CCNB P14635 ENST00000256442 K05868 1 0.65354 1.1523 0.65189 0.87457 0.79246 0.85443 Ebp2 cell fraction;insoluble fraction;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane fraction;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;protein binding cellular component biogenesis;cellular process;ribonucleoprotein complex biogenesis;ribosome biogenesis 7 7 7 27.5 27.5 27.5 34.852 3.345E-105 435120000 237680000 197440000 5368 IPI:IPI00745955.4 Probable rRNA-processing protein EBP2;EBNA1-binding protein 2;Nucleolar protein p40 EBNA1BP2;EBP2 Q99848 ENST00000236051 1 0.71858 1.4735 0.6892 0.96176 0.91263 0.90381 Ribosomal_S27e intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle;ribonucleoprotein complex;ribosome binding;caspase activator activity;enzyme activator activity;nucleic acid binding;structural constituent of ribosome;structural molecule activity;translation activator activity;translation factor activity, nucleic acid binding;zinc ion binding cell cycle checkpoint;DNA damage checkpoint;DNA metabolic process;DNA repair;induction of apoptosis;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to stress;translation 5 5 5 32.1 32.1 32.1 9.4771 1.3013E-40 1290100000 693220000 596830000 5369 IPI:IPI00746004.2;IPI:IPI00397358.4 40S ribosomal protein S27-like protein RPS27L Q71UM5 ENST00000330964;ENST00000380356 2 0.8954 1.6982 0.89529 1.191 1.099 1.1863 WD40 cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle actin binding;binding;cytoskeletal protein binding;protein binding cognition;multicellular organismal process;neurological system process;sensory perception;sensory perception of mechanical stimulus;sensory perception of sound;system process 39 39 39 74.6 74.6 74.6 66.193 0 10249000000 5341000000 4907800000 5371 IPI:IPI00746165.2;IPI:IPI00903292.2 WD repeat-containing protein 1;Actin-interacting protein 1;NORI-1 WDR1 O75083-1;O75083;O75083-3 ENST00000382451;ENST00000382452;ENST00000400001 2 0.6355 1.1761 0.67635 0.87307 0.76963 0.92595 WD40 intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;katanin complex;macromolecular complex;microtubule;microtubule associated complex;non-membrane-bounded organelle;organelle;organelle part;protein complex;spindle binding;cytoskeletal protein binding;microtubule binding;protein binding;protein dimerization activity;protein heterodimerization activity;tubulin binding intracellular protein transport;mitosis;negative regulation of metabolic process;negative regulation of microtubule depolymerization;nuclear division;organelle organization;positive regulation of metabolic process;protein targeting;transport 9 9 9 13.3 13.3 13.3 72.333 7.4838E-30 38648000 21114000 17534000 5372 IPI:IPI00746256.2 Katanin p80 WD40-containing subunit B1;p80 katanin KATNB1 Q9BVA0 ENST00000268509;ENST00000379661 1 0.71113 1.4002 0.71512 0.91682 0.90481 0.89065 RNB cytoplasm;exosome (RNase complex);intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;protein complex binding;catalytic activity;exonuclease activity;GDP-dissociation stimulator activity;hydrolase activity;nuclease activity;nucleic acid binding;protein binding;ribonuclease activity;RNA binding;small GTPase regulator activity cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;rRNA metabolic process;rRNA processing 20 20 20 26.7 26.7 26.7 109 4.7885E-205 368940000 199890000 169050000 5373 IPI:IPI00746351.2;IPI:IPI00183462.8 Exosome complex exonuclease RRP44;Ribosomal RNA-processing protein 44;Protein DIS3 homolog DIS3;KIAA1008;RRP44 Q9Y2L1-1;Q9Y2L1;Q9Y2L1-2 ENST00000377767;ENST00000377780 K01149 2 0.88899 1.7103 0.92007 1.1547 1.1209 1.1533 SH3BGR cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle catalytic activity;disulfide oxidoreductase activity;electron carrier activity;oxidoreductase activity;oxidoreductase activity, acting on sulfur group of donors;protein disulfide oxidoreductase activity biological regulation;cell redox homeostasis;cellular homeostasis;cellular process;homeostatic process;regulation of biological process;regulation of biological quality;regulation of cellular process 2 2 2 21.5 21.5 21.5 10.438 4.9948E-52 624000000 319870000 304140000 5374 IPI:IPI00746352.1 SH3 domain-binding glutamic acid-rich-like protein 3;SH3 domain-binding protein 1 SH3BGRL3;P1725 Q9H299 ENST00000270792;ENST00000374243 1 1.0774 NaN 0.67726 1.6075 NaN 0.92208 Ribosomal_L5;Ribosomal_L5_C cytosolic large ribosomal subunit;intracellular non-membrane-bounded organelle;intracellular organelle;large ribosomal subunit;macromolecular complex;non-membrane-bounded organelle;nucleolus;organelle;ribonucleoprotein complex;ribosomal subunit binding;nucleic acid binding;protein binding;RNA binding;rRNA binding;structural constituent of ribosome;structural molecule activity intracellular protein transport;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein targeting;RNA processing;rRNA processing;translational elongation;transport Ribosome 14 2 2 66.1 7.9 7.9 20.124 5.565E-140 22811000 12594000 10217000 5375 IPI:IPI00746438.2 60S ribosomal protein L11;CLL-associated antigen KW-12 RPL11 P62913-2;P62913 ENST00000374550 K02868 1 0.68897 1.2274 NaN 0.85708 0.83349 NaN UQ_con acid-amino acid ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleoside binding;nucleotide binding;purine nucleoside binding;ubiquitin-protein ligase activity DNA metabolic process;DNA repair;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;postreplication repair;protein modification process;proteolysis;ubiquitin-dependent protein catabolic process Ubiquitin mediated proteolysis 3 3 3 19.1 19.1 19.1 17.315 5.5995E-19 17950000 10298000 7652500 5376 IPI:IPI00746451.2 Ubiquitin-conjugating enzyme E2 A;Ubiquitin-protein ligase A;Ubiquitin carrier protein A;HR6A;hHR6A UBE2A;RAD6A P49459 ENST00000371558 K10573 1 0.52703 1.4292 0.64707 0.74381 0.95944 0.94385 PTR2 cell part;integral to membrane;intrinsic to membrane;membrane part active transmembrane transporter activity;oligopeptide transporter activity;peptide transporter activity;secondary active transmembrane transporter activity;symporter activity;transmembrane transporter activity;transporter activity establishment of localization;establishment of protein localization;oligopeptide transport;peptide transport;protein transport;transport 3 3 3 7.6 7.6 7.6 62.033 1.5304E-39 6766400 2688700 4077800 5377 IPI:IPI00746531.2 Solute carrier family 15 member 4;Peptide transporter 4;Peptide/histidine transporter 1 SLC15A4;PHT1;PTR4;FP12591 Q8N697-1;Q8N697 ENST00000266771;ENST00000376744 1 0.72046 1.585 0.73105 0.98496 0.97636 0.98337 ADH_N;ADH_zinc_N alcohol dehydrogenase (NAD) activity;binding;catalytic activity;electron carrier activity;fatty acid binding;lipid binding;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;zinc ion binding alcohol metabolic process;ethanol metabolic process;ethanol oxidation;metabolic process;monohydric alcohol metabolic process;oxidation reduction;response to chemical stimulus;response to redox state;response to stimulus 1- and 2-Methylnaphthalene degradation;3-Chloroacrylic acid degradation;Drug metabolism - cytochrome P450;Fatty acid metabolism;Glycolysis / Gluconeogenesis;Metabolism of xenobiotics by cytochrome P450;Methane metabolism;Retinol metabolism;Tyrosine metabolism 17 17 17 41.4 41.4 41.4 39.724 0 2461800000 1347000000 1114700000 5378 IPI:IPI00746777.3 Alcohol dehydrogenase class-3;Alcohol dehydrogenase class-III;Alcohol dehydrogenase 5;Alcohol dehydrogenase class chi chain;S-(hydroxymethyl)glutathione dehydrogenase;Glutathione-dependent formaldehyde dehydrogenase ADH5;ADHX;FDH P11766 ENST00000296412 K00001;K00121 1 0.50866 NaN NaN 0.71279 NaN NaN Helicase_C;ResIII cell part;holo TFIIH complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex ATP binding;ATP-dependent DNA helicase activity;binding;catalytic activity;damaged DNA binding;DNA binding;DNA helicase activity;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding cell cycle checkpoint;DNA catabolic process, endonucleolytic;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleotide-excision repair, DNA damage removal;nucleotide-excision repair, DNA duplex unwinding;system process Nucleotide excision repair 2 2 2 3.8 3.8 3.8 89.277 3.002E-12 7186800 4348100 2838700 5379 IPI:IPI00747053.2 TFIIH basal transcription factor complex helicase XPB subunit;Basic transcription factor 2 89 kDa subunit;BTF2-p89;TFIIH 89 kDa subunit;DNA repair protein complementing XP-B cells;Xeroderma pigmentosum group B-complementing protein;DNA excision repair protein ERCC-3 ERCC3;XPB;XPBC P19447 ENST00000285398 K10843 1 0.84457 0.86347 0.76966 1.074 0.60095 0.97704 Acyl-CoA_dh_1;Acyl-CoA_dh_M;Acyl-CoA_dh_N cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle acyl-CoA dehydrogenase activity;binding;catalytic activity;electron carrier activity;nucleoside binding;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on the CH-CH group of donors;purine nucleoside binding cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;regulation of transcription, DNA-dependent;transcription Valine, leucine and isoleucine degradation 7 7 7 18.3 18.3 18.3 45.069 7.2677E-60 42949000 21376000 21573000 5380 IPI:IPI00747159.1 Isobutyryl-CoA dehydrogenase, mitochondrial;Acyl-CoA dehydrogenase family member 8;Activator-recruited cofactor 42 kDa component ACAD8;ARC42;IBD Q9UKU7 ENST00000281182 K11538 1 0.72157 1.3173 0.71119 0.92243 0.88602 0.94165 RCC1 chromatin;chromosome;condensed chromosome;condensed nuclear chromosome;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;non-membrane-bounded organelle;nuclear chromatin;nuclear chromosome;organelle;organelle part binding;chromatin binding;enzyme regulator activity;guanyl-nucleotide exchange factor activity;protein binding;Ran guanyl-nucleotide exchange factor activity;Ras guanyl-nucleotide exchange factor activity;small GTPase regulator activity cytoskeleton organization;G1/S transition of mitotic cell cycle;microtubule cytoskeleton organization;microtubule-based process;mitosis;mitotic spindle organization;nuclear division;organelle organization;regulation of mitosis;spindle organization 14 14 14 53.9 53.9 53.9 44.969 0 865750000 461000000 404750000 5382 IPI:IPI00747309.1 Regulator of chromosome condensation;Chromosome condensation protein 1;Cell cycle regulatory protein RCC1;CHC1 P18754 ENST00000373832;ENST00000373833;ENST00000373834;ENST00000398958;ENST00000398962 K11493 1 0.92803 1.4959 NaN 1.2251 1.0433 NaN Arm;IBB cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;organelle part;pore complex;protein complex binding;protein binding establishment of protein localization;intracellular protein transport;intracellular transport;NLS-bearing substrate import into nucleus;nucleocytoplasmic transport;protein import;protein import into nucleus;protein targeting;protein transport;transport 13 7 7 23.8 14.6 14.6 60.579 2.0925E-216 52884000 28792000 24092000 5383 IPI:IPI00747764.3;IPI:IPI00413214.3 Importin subunit alpha-7;Karyopherin subunit alpha-6 KPNA6;IPOA7 O60684 ENST00000373625 2 0.27656 0.49379 0.30346 0.34119 0.35499 0.40198 HEAT cell part;chromosomal part;condensin complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear chromosome part;nuclear condensin complex;nuclear part;organelle part;protein complex binding cell cycle process;cell division;cellular component organization;cellular process;chromosome condensation;chromosome organization;DNA packaging;mitotic chromosome condensation;organelle organization 10 10 10 8.9 8.9 8.9 168.89 3.9033E-251 38167000 22351000 15816000 5384 IPI:IPI00747787.2 Condensin-2 complex subunit D3;Non-SMC condensin II complex subunit D3 NCAPD3;CAPD3;KIAA0056 P42695 ENST00000281189 K11491 1 0.80053 1.4376 0.85442 0.99096 0.96149 1.0915 BolA 6 6 6 74.4 74.4 74.4 10.116 1.2602E-170 962360000 496780000 465580000 5385 IPI:IPI00747913.2;IPI:IPI00410226.3 BolA-like protein 2 BOLA2;BOLA2A;My016;BOLA2B Q9H3K6-1;Q9H3K6;Q9H3K6-2 ENST00000305321;ENST00000330978;ENST00000338271 2 0.9082 1.4292 NaN 1.3306 0.85555 NaN BRCT;RhoGEF cell part;intracellular enzyme regulator activity;GTPase regulator activity;guanyl-nucleotide exchange factor activity;Ras guanyl-nucleotide exchange factor activity;Rho guanyl-nucleotide exchange factor activity;signal transducer activity;small GTPase regulator activity cell communication;cellular process;intracellular signaling cascade;positive regulation of signal transduction;regulation of cell communication;regulation of protein kinase cascade;regulation of signal transduction;signal transduction 6 6 6 8.8 8.8 8.8 105.07 1.4932E-16 29967000 15308000 14659000 5386 IPI:IPI00794284.2;IPI:IPI00748143.2 Protein ECT2;Epithelial cell-transforming sequence 2 oncogene ECT2 Q9H8V3-2;Q9H8V3;Q9H8V3-1 ENST00000232458;ENST00000392692 2 0.82987 1.5538 0.88736 1.0853 1.0408 1.1358 G-alpha binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity;signal transducer activity response to chemical stimulus;response to external stimulus;response to extracellular stimulus;response to nutrient;response to nutrient levels;response to stimulus Axon guidance;Chemokine signaling pathway;Gap junction;Leukocyte transendothelial migration;Long-term depression;Melanogenesis;Progesterone-mediated oocyte maturation;Tight junction 21 21 15 64.5 64.5 45.4 40.45 0 2876400000 1490900000 1385500000 5387 IPI:IPI00748145.2;IPI:IPI00217906.3;IPI:IPI00337415.9;IPI:IPI00398700.3;IPI:IPI00220281.3;IPI:IPI00248911.8;IPI:IPI00217269.3;IPI:IPI00218488.3 Guanine nucleotide-binding protein G(i), alpha-2 subunit;Adenylate cyclase-inhibiting G alpha protein GNAI2;GNAI2B P04899-1;P04899;P04899-2 ENST00000266027;ENST00000313601 K04630 8 0.73859 1.3331 NaN 0.94078 0.88681 NaN APG6 cell part;cytoplasmic part;Golgi apparatus part;Golgi membrane;intracellular organelle part;intracellular part;membrane;organelle membrane;organelle part binding;protein binding anti-apoptosis;autophagy;catabolic process;cellular defense response;cellular process;defense response;metabolic process;regulation of apoptosis;regulation of cell death;response to biotic stimulus;response to stress;response to virus Regulation of autophagy 5 5 5 10.4 10.4 10.4 51.896 3.134E-08 16080000 9409900 6670200 5388 IPI:IPI00748342.2 Beclin-1;Coiled-coil myosin-like BCL2-interacting protein;Protein GT197 BECN1;GT197 Q14457 ENST00000361523 K08334 1 0.50639 0.94967 0.70536 0.70099 0.59709 0.90998 cell part;integral to membrane;intrinsic to membrane;membrane part binding 10 10 10 7 7 7 200.07 5.0896E-108 33189000 18866000 14324000 5389 IPI:IPI00748360.2 Uncharacterized protein KIAA1797 KIAA1797 Q5VW36 ENST00000338382;ENST00000380249 1 NaN NaN 0.74946 NaN NaN 1.0006 extracellular matrix;extracellular region part;extracellular space;proteinaceous extracellular matrix 3 3 3 5.7 5.7 5.7 46.561 0.00029795 3404900 2042300 1362600 5390 IPI:IPI00748502.2 Cartilage-associated protein CRTAP;CASP O75718 ENST00000320954 1 0.6561 1.2278 0.69208 0.84647 0.79706 0.84702 Psf3 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle biosynthetic process;cellular process;DNA metabolic process;DNA replication;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 4 4 4 18.5 18.5 18.5 24.534 1.5301E-11 55931000 30841000 25089000 5391 IPI:IPI00748700.2;IPI:IPI00185097.1 DNA replication complex GINS protein PSF3;GINS complex subunit 3 GINS3;PSF3 Q9BRX5-1;Q9BRX5 ENST00000318129;ENST00000328514 K10734 2 0.68308 NaN 0.44011 0.91947 NaN 0.61394 GRAM;Myotub-related cell part;cytoplasm;extracellular matrix;extracellular region part;intracellular part;membrane;plasma membrane catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;phosphatase activity;phosphoprotein phosphatase activity;protein serine/threonine phosphatase activity;protein tyrosine phosphatase activity cellular process;dephosphorylation;developmental process;metabolic process;muscle organ development;phosphate metabolic process;phosphorus metabolic process;protein amino acid dephosphorylation;protein metabolic process;protein modification process 3 3 3 5.3 5.3 5.3 69.931 0.0010291 30786000 2168900 28617000 5392 IPI:IPI00748788.2 Myotubularin MTM1;CG2 Q13496 ENST00000306167 K01104 1 0.55939 1.2728 0.59739 0.75279 0.8162 0.78816 cell part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;organelle part;pore complex;protein complex binding;nucleocytoplasmic transporter activity;protein binding;transporter activity cellular process;establishment of protein localization;intracellular protein transport;mRNA export from nucleus;nucleobase, nucleoside, nucleotide and nucleic acid transport;nucleocytoplasmic transport;protein transport;RNA export from nucleus;transport 23 23 23 19.8 19.8 19.8 162.12 0 356220000 194710000 161510000 5393 IPI:IPI00748807.2;IPI:IPI00909318.1;IPI:IPI00221235.4 Nuclear pore complex protein Nup160;Nucleoporin Nup160;160 kDa nucleoporin NUP160;KIAA0197;NUP120 Q12769-1;Q12769 ENST00000263764;ENST00000378460 3 0.66489 1.6772 0.56887 0.9177 1.0415 0.83081 Ded_cyto;PH binding;enzyme binding;enzyme regulator activity;GTP binding;GTPase regulator activity;guanyl nucleotide binding;guanyl-nucleotide exchange factor activity;nucleotide binding;protein binding;purine nucleotide binding;ribonucleotide binding 5 5 5 3 3 3 237.67 6.4573E-34 24301000 13828000 10474000 5394 IPI:IPI00748916.2 Dedicator of cytokinesis protein 11;Zizimin-2;Activated Cdc42-associated guanine nucleotide exchange factor DOCK11;ZIZ2 Q5JSL3 ENST00000276202;ENST00000276204 1 0.6322 1.5708 0.58395 0.85717 1.0331 0.7598 cell part;membrane;plasma membrane 6 6 6 10.9 10.9 10.9 86.704 1.1051E-42 32962000 19013000 13949000 5395 IPI:IPI00749454.5 Raftlin;Raft-linking protein;Cell migration-inducing gene 2 protein RFTN1;KIAA0084;MIG2 Q14699 ENST00000334133 1 1.0247 1.8491 0.9989 1.3411 1.1784 1.3156 INCENP_ARK-bind centromeric heterochromatin;chromatin;heterochromatin;intracellular membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;microtubule;non-membrane-bounded organelle;nucleus;organelle;spindle binding;protein binding cell cycle phase;cell cycle process;cell division;cellular component organization;cellular process;chromosome segregation;cytokinesis;mitosis;nuclear division;organelle fission;organelle organization 11 11 11 12.9 12.9 12.9 105.43 2.8431E-111 149920000 75751000 74170000 5396 IPI:IPI00876972.1;IPI:IPI00759472.1 Inner centromere protein INCENP Q9NQS7-1;Q9NQS7;Q9NQS7-2 ENST00000394818 K11515 2 0.93559 1.8889 0.99143 1.2389 1.243 1.3069 Redoxin cell part;cytoplasmic part;cytosolic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;microbody;mitochondrion;organelle;peroxisome antioxidant activity;catalytic activity;cysteine-type endopeptidase inhibitor activity;endopeptidase inhibitor activity;enzyme inhibitor activity;oxidoreductase activity;oxidoreductase activity, acting on peroxide as acceptor;peroxidase activity cellular homeostasis;cellular process;defense response;inflammatory response;metabolic process;regulation of cell death;response to external stimulus;response to oxidative stress;response to reactive oxygen species;response to stress;response to wounding 11 11 11 47.2 47.2 47.2 22.026 4.7476E-171 1870100000 973450000 896670000 5398 IPI:IPI00024915.2;IPI:IPI00759663.1 Peroxiredoxin-5, mitochondrial;Prx-V;Peroxisomal antioxidant enzyme;PLP;Thioredoxin reductase;Thioredoxin peroxidase PMP20;Antioxidant enzyme B166;TPx type VI;Liver tissue 2D-page spot 71B;Alu corepressor 1 PRDX5;ACR1;SBBI10 P30044-1;P30044;P30044-2 ENST00000265462 K11187 2 0.76543 1.7368 0.79277 1.0702 1.1061 1.085 PARG_cat cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle catalytic activity;hydrolase activity;hydrolase activity, acting on glycosyl bonds;hydrolase activity, hydrolyzing O-glycosyl compounds;poly(ADP-ribose) glycohydrolase activity carbohydrate metabolic process;metabolic process;primary metabolic process 8 8 8 10.8 10.8 10.8 111.11 5.8172E-207 46015000 25319000 20696000 5399 IPI:IPI00759749.4;IPI:IPI00470744.1;IPI:IPI00787604.1 Poly(ADP-ribose) glycohydrolase PARG Q86W56-1;Q86W56;Q86W56-2;Q86W56-3 ENST00000402038 K07759 3 0.79802 1.7442 0.78679 1.0573 1.1099 1.0589 IQ;Myosin_head;PDZ cell part;cytoplasmic part;cytoskeletal part;ER-Golgi intermediate compartment;intracellular organelle part;intracellular part;macromolecular complex;myosin complex;organelle part;protein complex ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;motor activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity anti-apoptosis;negative regulation of apoptosis;negative regulation of biological process;negative regulation of programmed cell death;regulation of apoptosis;regulation of cell death;regulation of programmed cell death 34 34 34 19.5 19.5 19.5 233.11 0 533560000 288920000 244640000 5401 IPI:IPI00760846.1;IPI:IPI00828082.1;IPI:IPI00760925.2;IPI:IPI00334410.1;IPI:IPI00827840.2 Myosin-XVIIIa;Myosin containing a PDZ domain;Molecule associated with JAK3 N-terminus MYO18A;KIAA0216;MYSPDZ Q92614-1;Q92614;Q92614-4;Q92614-3;Q92614-2;Q92614-5 ENST00000354329;ENST00000354682;ENST00000359450 K10362 5 NaN 1.7365 0.65607 NaN 1.0644 0.95818 KRAB;zf-C2H2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 2 2 2 3.8 3.8 3.8 108.44 1.621E-14 3572500 1938800 1633600 5402 IPI:IPI00760941.3 Zinc finger protein 316 ZNF316 A6NFI3 ENST00000382252 1 0.75484 1.5809 0.90936 1.0732 1.0003 1.2373 PAT1 cell part;cytoplasmic mRNA processing body;cytoplasmic part;intracellular part;macromolecular complex;ribonucleoprotein complex 6 6 6 9.7 9.7 9.7 86.849 1.6157E-105 106260000 66759000 39498000 5403 IPI:IPI00885108.1;IPI:IPI00760958.3 Protein PAT1 homolog 1;PAT1-like protein 1 PATL1;OK/KNS-cl.5 Q86TB9-1;Q86TB9;Q86TB9-2 ENST00000300146 2 NaN 3.2156 1.6014 NaN 2.1083 2.1231 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 4 4 4 3.2 3.2 3.2 138.53 2.709E-16 3086300 1672900 1413400 5404 IPI:IPI00761051.1;IPI:IPI00844267.1;IPI:IPI00746361.2;IPI:IPI00914869.1 Erythroid differentiation-related factor 1 EDRF1;C10orf137 Q3B7T1-1;Q3B7T1;Q3B7T1-5;Q3B7T1-3 ENST00000337623;ENST00000356792;ENST00000392732 4 0.80977 1.8101 NaN 1.1235 1.107 NaN DUF2414 3 3 3 5.8 5.8 5.8 70.592 3.6117E-07 29508000 16216000 13292000 5405 IPI:IPI00782974.1;IPI:IPI00032056.4 Uncharacterized protein C17orf85;Protein ELG C17orf85 Q53F19-1;Q53F19;Q53F19-2 ENST00000158149;ENST00000389005 2 0.83508 1.5055 0.94848 1.0437 1.0654 1.1878 cwf21 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;nucleic acid binding;protein binding;RNA binding cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 32 32 32 16.7 16.7 16.7 299.61 0 2148900000 1078400000 1070500000 5406 IPI:IPI00782992.3;IPI:IPI00785023.2;IPI:IPI00784560.3 Serine/arginine repetitive matrix protein 2;Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa;Splicing coactivator subunit SRm300;300 kDa nuclear matrix antigen SRRM2;KIAA0324;SRL300;SRM300;HSPC075 Q9UQ35-1;Q9UQ35;Q9UQ35-2 ENST00000301740;ENST00000382301;ENST00000396975 3 NaN 1.5354 NaN NaN 0.93369 NaN Methyltransf_5 catalytic activity;methyltransferase activity;transferase activity;transferase activity, transferring one-carbon groups 5 5 5 17 17 17 46.121 3.7625E-130 13465000 5545700 7919700 5407 IPI:IPI00783001.1;IPI:IPI00641281.2;IPI:IPI00384389.4;IPI:IPI00877655.2 Putative S-adenosyl-L-methionine-dependent methyltransferase METT5D1;Methyltransferase 5 domain-containing protein 1 METT5D1 A6NJ78-1;A6NJ78 ENST00000303459;ENST00000342303;ENST00000379199;ENST00000407364 4 0.70791 1.5209 0.74728 0.9372 1.0301 1.0376 TGT binding;catalytic activity;cation binding;ion binding;metal ion binding;queuine tRNA-ribosyltransferase activity;transferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring pentosyl groups;zinc ion binding guanosine metabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;queuosine biosynthetic process;RNA processing;tRNA metabolic process;tRNA modification;tRNA processing 5 5 5 14.9 14.9 14.9 46.712 3.5404E-40 83429000 45822000 37607000 5408 IPI:IPI00783033.2 Queuine tRNA-ribosyltransferase domain-containing protein 1 QTRTD1 Q9H974 ENST00000281273 1 0.80587 1.6175 0.84186 1.0798 1.0333 1.1095 HGTP_anticodon;tRNA-synt_2b;WHEP-TRS cell fraction;cell part;soluble fraction aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;glycine-tRNA ligase activity;ligase activity;ligase activity, forming carbon-oxygen bonds;nucleoside binding;nucleotide binding;purine nucleoside binding cellular amino acid and derivative metabolic process;glycyl-tRNA aminoacylation;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;tRNA aminoacylation for protein translation;tRNA metabolic process Aminoacyl-tRNA biosynthesis;Glycine, serine and threonine metabolism 32 32 32 52.6 52.6 52.6 83.139 0 3112000000 1639600000 1472400000 5409 IPI:IPI00783097.3 Glycyl-tRNA synthetase;Glycine--tRNA ligase GARS P41250 ENST00000389266 K01880 1 0.75582 1.3181 0.80843 0.92942 0.93002 1.0088 5_nucleotid binding;catalytic activity;cation binding;hydrolase activity;ion binding;magnesium ion binding;metal ion binding 10 10 10 21.2 21.2 21.2 64.144 2.5228E-48 51591000 26232000 25359000 5411 IPI:IPI00783118.2;IPI:IPI00009662.2;IPI:IPI00100938.5;IPI:IPI00783682.1 5'-nucleotidase domain-containing protein 2 NT5DC2 Q9H857-2;Q9H857;Q9H857-1;Q9H857-3;Q9H857-4 ENST00000307076;ENST00000307092 4 0.8381 1.452 0.77606 1.0679 0.98223 1.0607 Ank;KH_1;MutS_V cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle adenyl nucleotide binding;ATP binding;binding;DNA binding;double-stranded DNA binding;mismatched DNA binding;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;purine nucleotide binding;ribonucleotide binding;RNA binding cellular process;DNA metabolic process;DNA repair;metabolic process;mismatch repair;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;response to DNA damage stimulus;response to stress 24 24 12 11.9 11.9 5.8 274.25 0 238840000 125400000 113440000 5413 IPI:IPI00784020.1;IPI:IPI00783186.2;IPI:IPI00868922.1;IPI:IPI00251783.2;IPI:IPI00953250.1 Ankyrin repeat domain-containing protein 17;Gene trap ankyrin repeat protein;Serologically defined breast cancer antigen NY-BR-16 ANKRD17;GTAR;KIAA0697 O75179-1;O75179;O75179-2 ENST00000330838;ENST00000358602 5 0.49749 0.9942 0.48101 0.64365 0.67885 0.61846 GCD14 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;methyltransferase activity;protein binding;RNA methyltransferase activity;S-adenosylmethionine-dependent methyltransferase activity;tRNA (adenine)-methyltransferase activity;tRNA methyltransferase activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;one-carbon metabolic process;RNA methylation;RNA processing;tRNA metabolic process;tRNA modification;tRNA processing 7 7 7 35.6 35.6 35.6 31.381 0 80938000 44095000 36843000 5414 IPI:IPI00783197.2;IPI:IPI00177856.9 tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRMT61A;tRNA(m1A58)-methyltransferase subunit TRMT61A TRMT61A;C14orf172;TRM61 Q96FX7-1;Q96FX7;Q96FX7-2 ENST00000299201;ENST00000389749 K07442 2 0.57456 1.1613 0.51439 0.74613 0.81314 0.64758 Cyclin_N binding;protein binding nuclear division;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of cyclin-dependent protein kinase activity;regulation of transcription, DNA-dependent;transcription;transcription, DNA-dependent 3 3 3 6.3 6.3 6.3 66.136 1.1051E-35 25439000 13779000 11660000 5415 IPI:IPI00783214.2;IPI:IPI00915260.1;IPI:IPI00431127.3;IPI:IPI00939345.1 Cyclin-K CCNK;CPR4 O75909-4;O75909;O75909-3;O75909-1;O75909-2 ENST00000216279;ENST00000389879 4 0.78286 1.5872 0.77352 1.0221 1.0326 1.019 PPR chromosome;condensed chromosome;condensed nuclear chromosome;cytoskeleton;membrane;nuclear chromosome;nuclear inner membrane;nuclear membrane;nuclear outer membrane;nucleoid;nucleoplasm;organelle inner membrane;organelle membrane;outer membrane beta-tubulin binding;binding;cytoskeletal protein binding;microtubule binding;nucleic acid binding;protein binding;RNA binding;tubulin binding metabolic process;microtubule-based movement;microtubule-based process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription;transport 80 80 80 64.1 64.1 64.1 157.9 0 5809200000 3098700000 2710500000 5416 IPI:IPI00783271.1 Leucine-rich PPR motif-containing protein, mitochondrial;130 kDa leucine-rich protein;LRP 130;GP130 LRPPRC;LRP130 P42704 ENST00000260665 1 1.0313 1.9366 1.2116 1.3043 1.3492 1.5056 WD40 9 9 9 11.5 11.5 11.5 103.96 1.081E-27 44001000 20431000 23569000 5417 IPI:IPI00783277.1;IPI:IPI00382979.4 WD repeat-containing protein 22;Breakpoint cluster region protein 2 WDR22;BCRG2;KIAA1824 Q96JK2-1;Q96JK2;Q96JK2-2 ENST00000341516 K11800 2 0.75548 1.5274 0.74222 0.96756 0.99883 0.99158 PPR cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle binding;protein binding 18 17 17 31.8 30.9 30.9 78.549 5.0275E-202 149920000 77638000 72287000 5418 IPI:IPI00783302.1;IPI:IPI00867557.1 Pentatricopeptide repeat-containing protein 3, mitochondrial;Transformation-related gene 15 protein PTCD3;TRG15 Q96EY7-1;Q96EY7 ENST00000254630 2 1.446 2.2549 1.1147 1.8482 1.4698 1.3668 Mad3_BUB1_I condensed chromosome kinetochore;intracellular non-membrane-bounded organelle;intracellular organelle;kinetochore;macromolecular complex;microtubule organizing center;non-membrane-bounded organelle;organelle;protein complex;spindle pole body ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cell cycle checkpoint;mitosis;mitotic cell cycle checkpoint;nuclear division;organelle organization;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;regulation of mitosis Cell cycle;Cell cycle - yeast;Progesterone-mediated oocyte maturation 10 10 10 10.2 10.2 10.2 122.37 1.1981E-78 39373000 17383000 21991000 5419 IPI:IPI00783305.1 Mitotic checkpoint serine/threonine-protein kinase BUB1;BUB1A BUB1;BUB1L O43683 ENST00000302759 K02178 1 0.68132 1.1101 NaN 0.82423 0.75558 NaN zf-CDGSH cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle 2 iron, 2 sulfur cluster binding;binding;cation binding;ion binding;iron ion binding;iron-sulfur cluster binding;metal cluster binding;metal ion binding;transition metal ion binding 3 3 3 26 26 26 14.215 1.2874E-08 16485000 8059600 8425000 5420 IPI:IPI00783359.2 CDGSH iron sulfur domain-containing protein 3, mitochondrial;MitoNEET-related protein 2 CISD3 P0C7P0 1 0.74233 1.2635 0.66628 0.96637 0.83524 0.86692 UQ_con acid-amino acid ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleoside binding;nucleotide binding;purine nucleoside binding;ubiquitin-protein ligase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein metabolic process;protein modification process;proteolysis;regulation of metabolic process Ubiquitin mediated proteolysis 22 22 22 19 19 19 141.29 1.7303E-204 583280000 309290000 273990000 5421 IPI:IPI00783378.3 Ubiquitin-conjugating enzyme E2 O;Ubiquitin-protein ligase O;Ubiquitin carrier protein O;Ubiquitin-conjugating enzyme E2 of 230 kDa UBE2O;KIAA1734 Q9C0C9 ENST00000319380 K10581 1 0.8098 1.8478 0.83049 1.1024 1.2229 1.0666 ATG11 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding biosynthetic process;cell cycle;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 4 4 4 3.4 3.4 3.4 183.09 9.6721E-64 374370000 199920000 174450000 5422 IPI:IPI00783392.2 RB1-inducible coiled-coil protein 1 RB1CC1;KIAA0203;RBICC Q8TDY2 ENST00000025008 1 0.79457 1.5132 0.81655 1.1033 0.97391 1.0745 TIG cellular process;establishment of localization;establishment of localization in cell;establishment of protein localization;exocytosis;protein transport;secretion;secretion by cell;transport;vesicle-mediated transport 14 14 14 18.3 18.3 18.3 104.07 4.2905E-60 62511000 32845000 29666000 5423 IPI:IPI00783559.1 Exocyst complex component 2;Exocyst complex component Sec5 EXOC2;SEC5;SEC5L1 Q96KP1 ENST00000230449 1 0.76518 1.4378 0.82488 0.9752 1.0135 1.0051 PBP intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;mitochondrion;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome 10 10 10 28.9 28.9 28.9 44.596 4.1588E-72 226660000 120000000 106660000 5424 IPI:IPI00783656.1 39S ribosomal protein L38, mitochondrial MRPL38;HSPC262 Q96DV4 ENST00000409963 1 0.57167 1.2607 0.52769 0.7525 0.85465 0.68884 cell part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;organelle part;pore complex;protein complex binding;protein binding anatomical structure formation;cellular process;intracellular protein transport;nucleobase, nucleoside, nucleotide and nucleic acid transport;protein complex assembly;protein import into nucleus, docking;protein transport;transport 23 23 23 15.1 15.1 15.1 227.92 1.0655E-204 358040000 201910000 156140000 5425 IPI:IPI00783781.1 Nuclear pore complex protein Nup205;Nucleoporin Nup205;205 kDa nucleoporin NUP205;C7orf14;KIAA0225 Q92621 ENST00000285968 1 0.84589 1.3743 0.59799 1.0936 0.87617 0.78461 DUF1162;UBA localization;macromolecule localization;protein localization 4 4 4 0.9 0.9 0.9 491.84 2.9049E-05 230660000 120670000 109990000 5426 IPI:IPI00784473.2;IPI:IPI00783859.2 Vacuolar protein sorting-associated protein 13D VPS13D;KIAA0453 Q5THJ4-1;Q5THJ4;Q5THJ4-2 ENST00000011700;ENST00000356315;ENST00000358136 2 0.92516 1.8369 0.97414 1.2092 1.1688 1.1977 Epimerase cell part;cytoplasm;intracellular part biliverdin reductase activity;binding;catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on the CH-CH group of donors;oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor cellular metabolic process;cellular process;metabolic process;oxidation reduction Porphyrin and chlorophyll metabolism 7 7 7 46.1 46.1 46.1 22.119 1.8593E-82 333940000 162750000 171190000 5427 IPI:IPI00783862.2 Flavin reductase;NADPH-dependent diaphorase;NADPH-flavin reductase;Biliverdin reductase B;Biliverdin-IX beta-reductase;Green heme-binding protein BLVRB;FLR P30043 ENST00000263368 K05901 1 0.71016 1.219 0.72533 0.95548 0.78671 0.93579 cell part;cell projection;cytoplasmic part;cytosol;dendrite;integral to membrane;integral to plasma membrane;intracellular part;intrinsic to membrane;intrinsic to plasma membrane;membrane part;neuron projection;plasma membrane part binding;protein binding 13 13 13 20.2 20.2 20.2 78.365 2.0678E-140 2173300000 1164900000 1008400000 5428 IPI:IPI00783872.2;IPI:IPI00873926.1 Caprin-1;Cytoplasmic activation- and proliferation-associated protein 1;GPI-anchored membrane protein 1;GPI-anchored protein p137;p137GPI;Cell cycle-associated protein 1;Membrane component chromosome 11 surface marker 1 CAPRIN1;GPIAP1;GPIP137;M11S1 Q14444-1;Q14444;Q14444-2 ENST00000341394;ENST00000389645 2 0.85086 1.5911 0.85673 1.1133 1.0731 1.0978 Hydrolase catalytic activity;hydrolase activity metabolic process 4 4 4 23.9 23.9 23.9 28.536 6.5977E-10 25154000 13332000 11822000 5429 IPI:IPI00783874.2;IPI:IPI00644472.2 Haloacid dehalogenase-like hydrolase domain-containing protein 2 HDHD2 Q9H0R4-1;Q9H0R4;Q9H0R4-2 ENST00000300605 2 0.81995 0.63339 NaN 1.1732 0.41281 NaN MRP;Sad1_UNC cell part;cytoplasmic part;intracellular part;perinuclear region of cytoplasm 3 3 3 4.9 4.9 4.9 91.112 2.9447E-24 9252800 4935900 4316900 5430 IPI:IPI00783943.2;IPI:IPI00873723.2;IPI:IPI00306682.4;IPI:IPI00335367.3 Protein unc-84 homolog A;Sad1/unc-84 protein-like 1 UNC84A;KIAA0810;SUN1 O94901-1;O94901;O94901-5 ENST00000297445;ENST00000405266;ENST00000407944 4 0.96217 1.9048 0.91205 1.2466 1.2406 1.2401 Adaptin_N;Gamma-COP cell part;COPI vesicle coat;cytoplasmic part;cytoplasmic vesicle part;cytosol;Golgi apparatus part;intracellular organelle part;intracellular part;macromolecular complex;membrane coat;membrane part;organelle part;protein complex;vesicle coat binding;protein binding;structural molecule activity cellular component organization;cellular process;intracellular protein transport;organelle organization;protein transport;retrograde vesicle-mediated transport, Golgi to ER;transport;vesicle coating;vesicle organization;vesicle-mediated transport 34 34 30 49.7 49.7 44.1 97.717 0 1423100000 730960000 692130000 5431 IPI:IPI00783982.1 Coatomer subunit gamma;Gamma-coat protein COPG;COPG1 Q9Y678 ENST00000314797 1 0.72067 1.3564 NaN 0.96559 0.86145 NaN Trs120 cell part;cytoplasmic part;endoplasmic reticulum;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle cell differentiation;cellular developmental process;cellular process;developmental process 2 2 2 2.1 2.1 2.1 139.44 1.2132E-11 1217400 699930 517450 5432 IPI:IPI00783996.2;IPI:IPI00940268.1;IPI:IPI00790904.1 Trafficking protein particle complex subunit 9;NIK- and IKBKB-binding protein;Tularik gene 1 protein TRAPPC9;KIAA1882;NIBP;T1 Q96Q05-2;Q96Q05;Q96Q05-1;Q96Q05-3 ENST00000301226;ENST00000389328 3 NaN 0.40066 NaN NaN 0.2504 NaN Ank;TPR_1 cell part;cytoplasm;intracellular part binding;protein binding 3 3 3 3.3 3.3 3.3 150.93 1.1731E-05 730980 327190 403780 5433 IPI:IPI00783999.3;IPI:IPI00889713.1 NF-kappa-B inhibitor-like protein 2;Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2;Inhibitor of kappa B-related protein NFKBIL2;IKBR Q96HA7-1;Q96HA7;Q96HA7-2 ENST00000292520;ENST00000409379 K09257 2 0.71998 1.5951 0.64322 0.95902 1.0365 0.86622 HEPN;ubiquitin adenyl nucleotide binding;ATP binding;binding;heat shock protein binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 7 7 7 1.9 1.9 1.9 521.12 3.8044E-13 67703000 38106000 29597000 5434 IPI:IPI00795015.2;IPI:IPI00784002.2 Sacsin SACS;KIAA0730 Q9NZJ4-1;Q9NZJ4;Q9NZJ4-2 ENST00000281578;ENST00000382292;ENST00000382298 2 0.66404 1.6725 NaN 0.9117 1.0212 NaN Pkinase_Tyr cytoplasm;cytoskeleton;endomembrane system;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;membrane;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle catalytic activity;non-membrane spanning protein tyrosine kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein tyrosine kinase activity;purine nucleoside binding;receptor signaling protein tyrosine kinase activity response to antibiotic;response to chemical stimulus;response to stimulus Jak-STAT signaling pathway;Pancreatic cancer;Pathways in cancer 2 2 2 2.2 2.2 2.2 133.28 0.0041372 32276000 16678000 15599000 5435 IPI:IPI00784013.1 Tyrosine-protein kinase JAK1;Janus kinase 1 JAK1;JAK1A;JAK1B P23458 ENST00000342505 K11217 1 0.77798 1.7049 0.74325 1.0549 1.1213 0.9967 Carboxyl_trans cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part ATP binding;binding;catalytic activity;CoA carboxylase activity;ligase activity;ligase activity, forming carbon-carbon bonds;methylcrotonoyl-CoA carboxylase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;purine nucleotide binding catabolic process;cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;leucine catabolic process;leucine metabolic process;metabolic process;nitrogen compound metabolic process;organic acid metabolic process Valine, leucine and isoleucine degradation 13 13 13 29.8 29.8 29.8 61.332 0 147870000 80714000 67152000 5436 IPI:IPI00784044.1;IPI:IPI00789428.1 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial;3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta;3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit;3-methylcrotonyl-CoA carboxylase 2 MCCC2;MCCB Q9HCC0-1;Q9HCC0;Q9HCC0-2 ENST00000323375;ENST00000340941 K01969 2 0.83359 1.6146 0.84205 1.0847 1.0475 1.0921 Cpn60_TCP1 cell part;cytoplasmic part;cytosol;intracellular part ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 46 46 46 72.8 72.8 72.8 59.62 0 10421000000 5424600000 4996200000 5437 IPI:IPI00784090.2 T-complex protein 1 subunit theta;CCT-theta;Renal carcinoma antigen NY-REN-15 CCT8;CCTQ;KIAA0002 P50990 ENST00000286788 K09500 1 0.69303 1.3132 0.7125 0.92509 0.88835 0.89365 Dus;zf-CCCH binding;catalytic activity;nucleic acid binding;nucleoside binding;nucleotide binding;oxidoreductase activity;oxidoreductase activity, acting on the CH-CH group of donors;purine nucleoside binding;purine nucleotide binding;zinc ion binding cellular process;metabolic process;ncRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;tRNA metabolic process;tRNA processing 10 10 10 20 20 20 72.593 2.1458E-144 134330000 65525000 68807000 5438 IPI:IPI00784107.1;IPI:IPI00640947.2;IPI:IPI00186125.2 tRNA-dihydrouridine synthase 3-like DUS3L Q96G46-1;Q96G46;Q96G46-2;Q96G46-3 ENST00000309061;ENST00000320699 K05544 3 1.0353 1.7175 1.0278 1.3943 1.1023 1.2795 ATP-synt_S1 integral to membrane;intrinsic to membrane;macromolecular complex;membrane;organelle membrane;organelle part;protein complex;proton-transporting two-sector ATPase complex, catalytic domain;proton-transporting V-type ATPase, V1 domain;vacuolar membrane ATP binding;binding;catalytic activity;cation transmembrane transporter activity;ion transmembrane transporter activity;nucleoside binding;nucleotide binding;purine nucleoside binding;transporter activity ATP biosynthetic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;transport Epithelial cell signaling in Helicobacter pylori infection;Oxidative phosphorylation;Vibrio cholerae infection 8 8 8 16.4 16.4 16.4 52.025 1.2504E-46 230780000 64519000 166260000 5439 IPI:IPI00784119.1 V-type proton ATPase subunit S1;Vacuolar proton pump subunit S1;V-ATPase S1 accessory protein;V-ATPase Ac45 subunit;Protein XAP-3 ATP6AP1;ATP6IP1;ATP6S1;VATPS1;XAP3 Q15904 ENST00000369762 K03662 1 1.1569 2.4544 1.1824 1.5359 1.5684 1.5882 Cpn60_TCP1 cell surface;coated pit;coated vesicle;cytoplasmic membrane-bounded vesicle;cytosol;early endosome;endosome;extracellular space;membrane;mitochondrial inner membrane;mitochondrial matrix;organelle inner membrane;organelle membrane;secretory granule ATP binding;binding;catalytic activity;DNA binding;DNA replication origin binding;lipopolysaccharide binding;nucleic acid binding;nucleoside binding;nucleotide binding;p53 binding;protein binding;purine nucleoside binding;single-stranded DNA binding cell activation;cytokine production;positive regulation of cytokine production;regulation of cytokine production;somatic diversification of immune receptors;somatic recombination of immunoglobulin genes during immune response Type I diabetes mellitus 61 61 61 78.2 78.2 78.2 61.054 0 58842000000 29132000000 29710000000 5440 IPI:IPI00784154.1 60 kDa heat shock protein, mitochondrial;Heat shock protein 60;60 kDa chaperonin;Chaperonin 60;Mitochondrial matrix protein P1;P60 lymphocyte protein;HuCHA60 HSPD1;HSP60 P10809 ENST00000345042;ENST00000388968 K04077 1 0.74837 1.2635 0.49876 0.95567 0.88221 0.64624 2 2 2 5.8 5.8 5.8 60.594 0.00011781 20527000 11034000 9493400 5441 IPI:IPI00784155.1;IPI:IPI00395342.3 SLAIN motif-containing protein 1 SLAIN1 Q8ND83-1;Q8ND83;Q8ND83-2 ENST00000267219;ENST00000351546;ENST00000389459 2 0.82682 1.5272 0.80756 1.0836 1.0032 1.0782 Adaptin_N;Alpha_adaptinC2;B2-adapt-app_C AP-type membrane coat adaptor complex;cell part;clathrin adaptor complex;coated pit;cytoplasmic part;cytosol;intracellular part;macromolecular complex;membrane part;protein complex binding;protein binding;protein transporter activity;substrate-specific transporter activity;transporter activity cellular process;intracellular protein transport;protein transport;regulation of defense response;regulation of immune effector process;regulation of immune system process;regulation of response to biotic stimulus;transport;vesicle-mediated transport Huntington's disease 36 36 16 35.9 35.9 18.1 105.69 0 1773700000 934610000 839110000 5442 IPI:IPI00784366.1;IPI:IPI00784156.1 AP-2 complex subunit beta-1;Adapter-related protein complex 2 beta-1 subunit;Beta2-adaptin;Beta-adaptin;Plasma membrane adaptor HA2/AP2 adaptin beta subunit;Clathrin assembly protein complex 2 beta large chain;AP105B AP2B1;ADTB2;CLAPB1 P63010-2;P63010;P63010-1 ENST00000262325;ENST00000312678 K11825 2 0.76123 1.3433 0.73036 1.01 0.91434 0.95402 S1;Tex_N cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;DNA binding;hydrolase activity;hydrolase activity, acting on ester bonds;nucleic acid binding;protein binding;RNA binding;transcription elongation regulator activity;transcription factor activity;transcription regulator activity chromatin organization;chromatin remodeling;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 30 30 18 18.2 18.2 11.3 199.07 6.8462E-97 556560000 299070000 257490000 5443 IPI:IPI00784161.1;IPI:IPI00456683.1 Transcription elongation factor SPT6;Tat-cotransactivator 2 protein SUPT6H;KIAA0162;SPT6H Q7KZ85-1;Q7KZ85 ENST00000314616;ENST00000347486 K11292 2 0.84848 1.5278 0.7617 1.1227 0.95499 1.1041 DZF cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;RNA binding;transition metal ion binding;zinc ion binding developmental process;multicellular organismal development;multicellular organismal process 15 15 15 20.8 20.8 20.8 117.69 0 146830000 75183000 71644000 5444 IPI:IPI00784224.1 Zinc finger RNA-binding protein;M-phase phosphoprotein homolog ZFR Q96KR1 ENST00000265069 1 0.73578 1.5897 0.63561 1.0539 0.96562 0.90195 GYF binding;protein binding 6 6 6 7.4 7.4 7.4 150.07 2.7471E-117 120600000 66243000 54352000 5445 IPI:IPI00784233.2;IPI:IPI00647635.3 PERQ amino acid-rich with GYF domain-containing protein 2;GRB10-interacting GYF protein 2;Trinucleotide repeat-containing gene 15 protein GIGYF2;KIAA0642;PERQ2;TNRC15 Q6Y7W6-1;Q6Y7W6;Q6Y7W6-3 ENST00000373563;ENST00000373566;ENST00000409547 2 0.79701 1.5094 0.87403 1.0965 0.99938 1.176 SH2;STAT_alpha;STAT_bind;STAT_int cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;calcium ion binding;DNA binding;hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity;nucleic acid binding;receptor signaling protein activity;signal transducer activity;transcription factor activity negative regulation of transcription from RNA polymerase II promoter;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription Acute myeloid leukemia;Adipocytokine signaling pathway;Chemokine signaling pathway;Jak-STAT signaling pathway;Pancreatic cancer;Pathways in cancer 24 24 24 40.4 40.4 40.4 88.067 0 444320000 229490000 214830000 5447 IPI:IPI00784414.1;IPI:IPI00306436.1 Signal transducer and activator of transcription 3;Acute-phase response factor STAT3;APRF P40763-1;P40763;P40763-2 ENST00000264657;ENST00000389272 K04692 2 NaN 1.0169 0.63134 NaN 0.73884 0.80974 SpoU_methylase;SpoU_sub_bind cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle binding;catalytic activity;methyltransferase activity;nucleic acid binding;RNA binding;RNA methyltransferase activity;transferase activity;transferase activity, transferring one-carbon groups cellular biopolymer metabolic process;cellular process;macromolecule metabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing 4 4 4 11.6 11.6 11.6 38.638 3.7941E-14 8464800 4347200 4117600 5448 IPI:IPI00784477.3;IPI:IPI00827737.1 rRNA methyltransferase 1, mitochondrial;Mitochondrial large ribosomal RNA ribose methylase MRM1 Q6IN84-1;Q6IN84 ENST00000250156 2 0.5162 1.3656 NaN 0.72714 0.90641 NaN cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle cellular component organization;cellular process;chromatin modification;chromatin organization;chromosome organization;organelle organization 2 2 2 6 6 6 67.138 1.7801E-80 561500 304820 256680 5449 IPI:IPI00784883.4;IPI:IPI00953625.1 Male-specific lethal 1 homolog;Male-specific lethal 1-like 1;Male-specific lethal-1 homolog 1 MSL1;MSL1L1 Q68DK7-1;Q68DK7;Q68DK7-3 ENST00000339569 2 0.8189 1.5369 0.77323 0.99748 1.0797 0.97778 2 2 2 1.9 1.9 1.9 127.14 0.0022215 55577000 29317000 26260000 5450 IPI:IPI00784980.1 Coiled-coil domain-containing protein 158 CCDC158 Q5M9N0-1;Q5M9N0 ENST00000318586;ENST00000388914 1 0.7784 1.5897 NaN 1.0319 1.0106 NaN C1-set cell fraction;cell part;extracellular region;insoluble fraction;membrane fraction antigen binding;binding;protein binding immune response;immune system process;response to stimulus 3 3 3 7.7 7.7 7.7 51.082 2.3579E-12 6743300 4956700 1786600 5451 IPI:IPI00785084.2;IPI:IPI00827754.3;IPI:IPI00930442.1;IPI:IPI00426051.3 Ig gamma-1 chain C region;Ig gamma-3 chain C region;Heavy chain disease protein;HDC IGHG1;IGHG3 P01857;P01860 ENST00000390548;ENST00000390549;ENST00000390550;ENST00000390551 4 0.90294 1.8112 0.91672 1.2047 1.1567 1.2314 W2 cell part;cytoplasm;intracellular part binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 17 17 15 35.6 35.6 32.5 48.043 1.0838E-93 1083700000 568080000 515580000 5452 IPI:IPI00785096.5;IPI:IPI00180128.4;IPI:IPI00900322.1 Basic leucine zipper and W2 domain-containing protein 1;Protein Orf;Putative basic leucine zipper and W2 domain-containing protein 1-like 1 BZW1;BZAP45;KIAA0005;BZW1L1 Q7L1Q6-1;Q7L1Q6;Q7L1Q6-2;P0C7T9 ENST00000353957;ENST00000409226;ENST00000409600;ENST00000410110;ENST00000409521 3 0.61248 1.5172 0.66798 0.86051 0.9821 0.88479 M16C_assoc;Peptidase_M16_C cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;mitochondrial matrix;mitochondrial part;nucleus;organelle;organelle part binding;catalytic activity;cation binding;endopeptidase activity;enzyme activator activity;enzyme regulator activity;hydrolase activity;ion binding;metalloendopeptidase activity;metallopeptidase activity;peptidase activity;zinc ion binding biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis 18 18 18 24 24 24 117.55 4.4271E-119 232940000 128550000 104400000 5454 IPI:IPI00787827.1;IPI:IPI00952680.1 Presequence protease, mitochondrial;Pitrilysin metalloproteinase 1 PITRM1;KIAA1104;MP1 Q5JRX3-2;Q5JRX3;Q5JRX3-1 ENST00000224949;ENST00000380989 2 0.95265 1.9675 NaN 1.2991 1.2294 NaN Inositol_P cell part;cytoplasmic part;Golgi apparatus;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;inositol or phosphatidylinositol phosphatase activity;inositol-1(or 4)-monophosphatase activity;magnesium ion binding;phosphatase activity 2 2 2 4.5 4.5 4.5 38.681 3.1467E-08 11934000 6457500 5476100 5455 IPI:IPI00787853.2 Inositol monophosphatase 3;Inositol-1(or 4)-monophosphatase 3;Myo-inositol monophosphatase A3;Inositol monophosphatase domain-containing protein 1 IMPAD1;IMPA3 Q9NX62 ENST00000262644 1 0.59731 1.228 0.70631 0.82746 0.80761 0.94485 LIM adherens junction;anchoring junction;cell junction;cell part;cell-substrate adherens junction;cell-substrate junction;focal adhesion;intracellular organelle;membrane part;membrane-bounded organelle;nucleus;organelle;plasma membrane part binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding aging;cell aging;cellular process;developmental process 6 6 6 26.4 26.4 26.4 38.421 9.9863E-45 72872000 41093000 31780000 5456 IPI:IPI00788612.1;IPI:IPI00398576.3;IPI:IPI00815737.3;IPI:IPI00867554.1 LIM and senescent cell antigen-like-containing domain protein 1;Particularly interesting new Cys-His protein 1;Renal carcinoma antigen NY-REN-48;LIM and senescent cell antigen-like-containing domain protein 2;Particularly interesting new Cys-His protein 2;LIM-like protein 2 LIMS1;PINCH;PINCH1;LIMS2;PINCH2 P48059;Q7Z4I7-2;Q7Z4I7;Q7Z4I7-1;Q7Z4I7-3 ENST00000332345;ENST00000338045;ENST00000393310;ENST00000409441;ENST00000410093;ENST00000324938;ENST00000355119 4 0.8265 1.61 0.86323 1.0143 1.073 1.0912 PGAM cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 16 16 16 48.8 48.8 48.8 32.004 4.317E-129 769940000 404190000 365740000 5457 IPI:IPI00788907.2;IPI:IPI00063242.5 Phosphoglycerate mutase family member 5;Bcl-XL-binding protein v68 PGAM5 Q96HS1-1;Q96HS1;Q96HS1-2 ENST00000317555 2 1.0296 1.7548 1.1958 1.3338 1.2383 1.45 Band_7 caveola;cell part;cell surface;membrane part;membrane raft;plasma membrane part binding;protein binding anatomical structure development;biological adhesion;cell adhesion;cellular process;developmental process;epidermis development;tissue development 10 10 10 30.8 30.8 30.8 47.064 8.5135E-98 74907000 37116000 37791000 5458 IPI:IPI00789008.1 Flotillin-2;Epidermal surface antigen FLOT2;ESA1;M17S1 Q14254 ENST00000335362;ENST00000394906;ENST00000394908 1 0.74023 1.6181 0.82396 1.021 1.061 1.0894 Pinin_SDK_memA;Pinin_SDK_N cell junction;cell-cell junction;cytoskeletal part;desmosome;intermediate filament;intracellular part;macromolecular complex;membrane part;nuclear body;nuclear part;nuclear speck;organelle part;ribonucleoprotein complex;spliceosomal complex binding;DNA binding;nucleic acid binding;protein binding;structural molecule activity cell adhesion;cell cycle;metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;RNA processing;RNA splicing;transcription 10 10 10 16.3 16.3 16.3 81.613 6.9717E-194 990040000 514440000 475610000 5459 IPI:IPI00789041.2;IPI:IPI00002649.2 Pinin;140 kDa nuclear and cell adhesion-related phosphoprotein;Domain-rich serine protein;Melanoma metastasis clone A protein;Desmosome-associated protein;SR-like protein;Nuclear protein SDK3 PNN;DRS;MEMA Q9H307-1;Q9H307;Q9H307-2 ENST00000216832 2 0.48561 NaN NaN 0.60855 NaN NaN BACK;BTB;Kelch_1 binding;protein binding 2 2 2 4 4 4 63.638 7.5913E-18 232120 232120 0 5460 IPI:IPI00789341.2;IPI:IPI00747824.1 Kelch-like protein 18 KLHL18;KIAA0795;OK/SW-cl.74 O94889-1;O94889;O94889-2 ENST00000232766 K10455 2 0.62777 1.0516 0.50374 0.78528 0.74667 0.63966 Drf_DAD;Drf_FH3;Drf_GBD;FH2 actin binding;binding;cytoskeletal protein binding;enzyme binding;GTPase binding;protein binding;Ras GTPase binding;Rho GTPase binding;small GTPase binding actin cytoskeleton organization;actin filament-based process;cellular component organization;cellular process;cytoskeleton organization;organelle organization Regulation of actin cytoskeleton 7 7 7 7.5 7.5 7.5 136.92 3.2425E-80 8438800 4670100 3768700 5461 IPI:IPI00789805.3;IPI:IPI00794752.1;IPI:IPI00791213.1;IPI:IPI00791794.1;IPI:IPI00855715.1;IPI:IPI00747250.6;IPI:IPI00655865.5 Protein diaphanous homolog 3;Diaphanous-related formin-3 DIAPH3;DIAP3 Q9NSV4-3;Q9NSV4;Q9NSV4-4;Q9NSV4-5;Q9NSV4-6;Q9NSV4-7;Q9NSV4-1 ENST00000267214;ENST00000400324;ENST00000400326;ENST00000400327;ENST00000400330 K05745 7 1.2385 2.0429 1.1162 1.5777 1.3381 1.5063 cell part;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;microtubule;microtubule associated complex;organelle part;protein complex binding;protein binding;structural molecule activity 33 33 33 16.4 16.4 16.4 305.62 8.8006E-285 472490000 230950000 241530000 5462 IPI:IPI00789977.2;IPI:IPI00008868.3 Microtubule-associated protein 1A;Proliferation-related protein p80;MAP1 light chain LC2 MAP1A;MAP1L P78559 ENST00000382031;ENST00000399453 2 0.60692 0.96163 0.49615 0.74956 0.61309 0.64095 17 17 17 10.1 10.1 10.1 189.03 1.7971E-49 97066000 53389000 43677000 5463 IPI:IPI00790098.3;IPI:IPI00796104.3;IPI:IPI00793355.3;IPI:IPI00745978.3;IPI:REV_IPI00479786.5;IPI:REV_IPI00855957.2 Uncharacterized protein C3orf63;Retinoblastoma-associated protein RAP140;CTCL tumor antigen se89-1 C3orf63;KIAA1105 Q9UK61-1;Q9UK61;Q9UK61-4;Q9UK61-3;Q9UK61-2 ENST00000355628 6 0.75675 2.0387 1.2991 1.0046 1.3029 1.8122 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding 4 4 4 33.7 33.7 33.7 17.9 9.0239E-77 33944000 18569000 15375000 5464 IPI:IPI00790228.1 Uncharacterized potential DNA-binding protein C17orf49 C17orf49 Q8IXM2 ENST00000293804 1 0.52457 1.1726 0.52617 0.70925 0.75427 0.71484 IQ;Myosin_head;Myosin_N;Myosin_tail_1 actin filament bundle;actomyosin;cell cortex;cell division site part;cleavage furrow;cytoplasmic part;cytoskeletal part;intracellular part;macromolecular complex;midbody;myosin complex;organelle part;protein complex;stress fiber actin binding;ATP binding;binding;calmodulin binding;catalytic activity;cytoskeletal protein binding;microfilament motor activity;motor activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity actin filament-based movement;actin filament-based process;cell cycle process;cellular process;cytokinesis;cytokinesis after mitosis;regulation of anatomical structure morphogenesis;regulation of cell morphogenesis;regulation of cell shape;transport Tight junction 78 60 55 38.7 31.9 29.8 231.37 0 2150100000 1231400000 918650000 5465 IPI:IPI00790503.3;IPI:IPI00397526.3;IPI:IPI00479307.4 Myosin-10;Myosin heavy chain 10;Myosin heavy chain, non-muscle IIb;Non-muscle myosin heavy chain IIb;Cellular myosin heavy chain, type B;Non-muscle myosin heavy chain B MYH10 P35580-3;P35580;P35580-1;P35580-2 ENST00000269243;ENST00000360416;ENST00000379980;ENST00000396239 K10352 3 0.42007 1.1477 0.40347 0.57349 0.74374 0.53444 Nucleopor_Nup85 condensed chromosome kinetochore;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;kinetochore;macromolecular complex;membrane;non-membrane-bounded organelle;nuclear membrane;nuclear pore;organelle;organelle membrane;spindle cellular process;establishment of protein localization;intracellular protein transport;intracellular transport;mRNA transport;nucleic acid transport;nucleobase, nucleoside, nucleotide and nucleic acid transport;protein transport;RNA transport;transport 13 13 13 28 28 28 75.019 6.4121E-175 129900000 76867000 53033000 5466 IPI:IPI00790530.1 Nucleoporin NUP85;Nuclear pore complex protein Nup85;85kDa nucleoporin;Nucleoporin Nup75;Pericentrin-1;FROUNT NUP85;NUP75;PCNT1 Q9BW27 ENST00000245544 1 0.9075 1.4663 0.85887 1.1106 1.0403 1.0613 Med1-Trap220 cell part;intracellular organelle part;intracellular part;macromolecular complex;mediator complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;DNA binding;nucleic acid binding;protein binding;receptor activity;receptor binding;RNA polymerase II transcription factor activity;signal transducer activity;transcription coactivator activity;transcription cofactor activity cell communication;intracellular signaling cascade;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;signal transduction;transcription initiation;transcription initiation from RNA polymerase II promoter 3 3 3 2.5 2.5 2.5 168.48 0.0006617 10762000 5601600 5160100 5468 IPI:IPI00829826.1;IPI:IPI00790747.1 Mediator of RNA polymerase II transcription subunit 1;Mediator complex subunit 1;Peroxisome proliferator-activated receptor-binding protein;Thyroid hormone receptor-associated protein complex 220 kDa component;Thyroid receptor-interacting protein 2;p53 regulatory protein RB18A;Vitamin D receptor-interacting protein complex component DRIP205;Activator-recruited cofactor 205 kDa component MED1;ARC205;CRSP1;CRSP200;DRIP205;DRIP230;PBP;PPARBP;PPARGBP;RB18A;TRAP220;TRIP2 Q15648-1;Q15648;Q15648-3 ENST00000300651;ENST00000394287 2 0.56687 NaN NaN 0.83012 NaN NaN cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;intracellular part;macromolecular complex;membrane;membrane part;nuclear membrane;nuclear part;nuclear pore;organelle membrane;organelle part;protein complex cellular process;establishment of protein localization;intracellular protein transport;intracellular transport;mRNA transport;nucleic acid transport;nucleobase, nucleoside, nucleotide and nucleic acid transport;protein transport;RNA transport;transport 2 1 1 3 2.1 2.1 127.72 0.00025657 3992300 2154500 1837800 5469 IPI:IPI00902533.1;IPI:IPI00902621.1;IPI:IPI00790779.1 Nuclear envelope pore membrane protein POM 121;Pore membrane protein of 121 kDa;Nuclear envelope pore membrane protein POM 121A POM121;KIAA0618;NUP121;POM121A Q96HA1-1;Q96HA1;Q96HA1-3;Q96HA1-2 ENST00000257665 3 0.66466 1.4802 0.7297 0.90003 0.95531 1.0288 NMD3 cell part;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;nucleoplasm;organelle;organelle part establishment of localization;establishment of protein localization;protein transport;transport 6 6 6 14.5 14.5 14.5 57.603 1.2077E-108 114720000 62128000 52588000 5470 IPI:IPI00790937.3 60S ribosomal export protein NMD3 NMD3;CGI-07 Q96D46 ENST00000351193 K07562 1 0.56169 1.1428 0.54722 0.74393 0.73016 0.7276 CPL endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;non-membrane-bounded organelle;nucleolus;organelle;organelle part binding;nucleic acid binding;RNA binding 25 25 25 42 42 42 77.291 0 611770000 334270000 277500000 5471 IPI:IPI00791325.1 Pumilio domain-containing protein KIAA0020;HBV X-transactivated gene 5 protein;Minor histocompatibility antigen HA-8 KIAA0020;XTP5 Q15397 ENST00000382032;ENST00000397885 1 NaN 2.2623 NaN NaN 1.3511 NaN SAM_1 binding;protein binding 4 4 4 6.1 6.1 6.1 75.483 4.4364E-58 1062900 542500 520390 5473 IPI:IPI00791720.1 Protein Smaug homolog 2;Sterile alpha motif domain-containing protein 4B SAMD4B;SMAUG2 Q5PRF9 ENST00000314471 1 1.2505 NaN 1.2498 1.738 NaN 1.7394 DUF1077 cell part;integral to membrane;intrinsic to membrane;membrane part 2 1 1 13.2 5.9 5.9 15.088 6.5526E-05 75895000 37232000 38664000 5474 IPI:IPI00791782.2 Transmembrane protein 85;Cell proliferation-inducing gene 17 protein TMEM85;HSPC184;PIG17 Q5J8M3-3;Q5J8M3 ENST00000249209;ENST00000267750 1 0.60742 0.75531 0.6915 0.81774 0.5281 0.99366 Ank;BTB;RCC1 cell part;cytoplasm;intracellular part;membrane binding;enzyme binding;enzyme inhibitor activity;enzyme regulator activity;kinase binding;kinase inhibitor activity;kinase regulator activity;protein binding;protein kinase binding;protein kinase inhibitor activity;protein kinase regulator activity calcium ion transport;cation transport;cellular calcium ion homeostasis;cellular ion homeostasis;ion transport;negative regulation of protein amino acid phosphorylation;regulation of protein amino acid phosphorylation;transport 3 3 3 2.4 2.4 2.4 150.53 9.8805E-07 62747000 34386000 28361000 5475 IPI:IPI00792333.2;IPI:IPI00829736.1;IPI:IPI00910313.2 Inhibitor of Bruton tyrosine kinase IBTK;BTKI;KIAA1417 Q9P2D0-1;Q9P2D0;Q9P2D0-2;Q9P2D0-3 ENST00000306270 3 0.63 1.3787 0.59137 0.83089 0.91436 0.79575 RRM_1;SAP cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;nucleotide binding;RNA binding apoptosis;biosynthetic process;cell death;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 15 15 15 16.5 16.5 16.5 117.15 1.1282E-256 447470000 248290000 199170000 5476 IPI:IPI00792743.1 SAFB-like transcription modulator;Modulator of estrogen-induced transcription SLTM;MET Q9NWH9 ENST00000249736;ENST00000380516 1 0.76333 1.6004 0.75828 0.99941 1.037 1.0131 Creatinase_N;Peptidase_M24 cell part;cytoplasm;intracellular part aminopeptidase activity;binding;catalytic activity;cation binding;exopeptidase activity;hydrolase activity;ion binding;manganese ion binding;metal ion binding;metalloexopeptidase activity;metallopeptidase activity;peptidase activity biopolymer catabolic process;biopolymer metabolic process;catabolic process;cellular process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;protein catabolic process;protein metabolic process;proteolysis 22 22 22 45.3 45.3 45.3 74.797 8.7701E-158 889060000 486010000 403050000 5477 IPI:IPI00793375.1;IPI:IPI00607814.3 Xaa-Pro aminopeptidase 1;X-Pro aminopeptidase 1;X-prolyl aminopeptidase 1, soluble;Cytosolic aminopeptidase P;Soluble aminopeptidase P;Aminoacylproline aminopeptidase XPNPEP1;XPNPEPL;XPNPEPL1 Q9NQW7-1;Q9NQW7;Q9NQW7-2 ENST00000322238;ENST00000369680;ENST00000403138 K01262 2 0.66207 1.3396 0.68975 0.8633 0.87883 0.91668 HEAT cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane part;non-membrane-bounded organelle;nuclear part;nuclear pore;nucleolus;organelle;organelle part;protein complex binding;enzyme binding;enzyme inhibitor activity;enzyme regulator activity;GTPase inhibitor activity;protein binding;protein transporter activity;Ran GTPase binding;Ras GTPase binding;substrate-specific transporter activity;transporter activity cellular process;intracellular protein transport;NLS-bearing substrate import into nucleus;nucleocytoplasmic transport;protein complex assembly;protein import into nucleus;protein import into nucleus, docking;protein targeting;transport 48 48 6 50.1 50.1 5.1 125.54 0 3801300000 2006800000 1794500000 5478 IPI:IPI00939304.1;IPI:IPI00793443.2 Importin-5;Importin subunit beta-3;Karyopherin beta-3;Ran-binding protein 5 IPO5;KPNB3;RANBP5 O00410-3;O00410;O00410-1 ENST00000261574;ENST00000357602;ENST00000403772 2 0.68478 NaN 0.6925 0.92283 NaN 0.89503 Snf7 cell part;cytoplasmic part;cytoplasmic vesicle membrane;cytoplasmic vesicle part;endosomal part;endosome membrane;intracellular organelle part;intracellular part;late endosome membrane;membrane;organelle membrane;organelle part;vesicle membrane binding;lipid binding;protein binding establishment of localization;establishment of protein localization;protein transport;transport 4 1 1 18.9 6 6 29.803 1.9865E-73 53535000 30973000 22562000 5481 IPI:IPI00794397.1 Charged multivesicular body protein 4a;Chromatin-modifying protein 4a;Vacuolar protein-sorting-associated protein 32-1;SNF7-1;hSnf-1;SNF7 homolog associated with Alix-2 CHMP4A;C14orf123;SHAX2;CDA04;HSPC134 Q9BY43 ENST00000347519 K12194 1 0.72404 1.3259 0.52651 0.96688 0.87441 0.63431 BRK;Chromo;Helicase_C;SNF2_N cell part;chromatin;chromosomal part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;nucleus;organelle;organelle part ATP binding;binding;catalytic activity;chromatin binding;DNA binding;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity cell activation;heart morphogenesis;immune system process;in utero embryonic development;leukocyte differentiation;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of peptide secretion;skeletal system development 11 10 7 3.6 3.3 2.2 335.92 1.1969E-31 142020000 81609000 60410000 5482 IPI:IPI00794880.1;IPI:IPI00472901.4 Chromodomain-helicase-DNA-binding protein 7;ATP-dependent helicase CHD7 CHD7;KIAA1416 Q9P2D1-1;Q9P2D1 ENST00000307121 2 0.78775 1.6049 0.789 1.0613 1.0303 1.077 FF;WW binding;protein binding 4 2 2 5.8 3.1 3.1 65.659 1.1628E-07 217630000 115990000 101640000 5483 IPI:IPI00794939.1 Transcription elongation regulator 1-like protein TCERG1L Q5VWI1 ENST00000368642 1 0.77231 1.6171 NaN 1.0086 1.0051 NaN 5 5 5 31.7 31.7 31.7 28.17 3.9729E-92 15731000 9084200 6647300 5484 IPI:IPI00795249.2 Uncharacterized protein C12orf43 C12orf43 Q96C57 ENST00000288757 1 0.74553 1.4917 0.74973 1.0019 0.97075 1.0156 NDK cell part;cell projection;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;lamellipodium;membrane-bounded organelle;nucleus;organelle;ruffle ATP binding;binding;catalytic activity;DNA binding;magnesium ion binding;nucleic acid binding;nucleoside binding;nucleoside diphosphate kinase activity;nucleotide binding;protein binding;purine nucleoside binding;transcription factor activity GTP biosynthetic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;purine nucleotide biosynthetic process;purine nucleotide metabolic process;pyrimidine nucleoside metabolic process;pyrimidine nucleotide metabolic process Purine metabolism;Pyrimidine metabolism 15 15 5 77.5 77.5 25.1 30.137 7.4099E-281 17054000000 9058400000 7995900000 5485 IPI:IPI00795292.1;IPI:IPI00026260.1;IPI:IPI00029091.1 Nucleoside diphosphate kinase B;nm23-H2;C-myc purine-binding transcription factor PUF NME2;NM23B P22392-2;P22392;P22392-1 ENST00000376392;ENST00000393190;ENST00000393191;ENST00000393192;ENST00000393193;ENST00000393194;ENST00000393198;ENST00000393199 K00940 3 0.83453 1.6305 1.2299 1.1989 1.0836 1.6099 Arm binding 10 10 10 16.8 16.8 16.8 75.509 1.5043E-48 80233000 39552000 40681000 5486 IPI:IPI00795553.2;IPI:IPI00790407.2;IPI:IPI00794568.2;IPI:IPI00396379.3 Armadillo repeat-containing protein 8 ARMC8;S863-2 Q8IUR7-1;Q8IUR7;Q8IUR7-2;Q8IUR7-3;Q8IUR7-6 ENST00000289094;ENST00000358441 4 0.56425 1.3825 NaN 0.82524 0.83448 NaN SR-25 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle cellular biopolymer metabolic process;cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 3 3 3 13.1 13.1 13.1 44.915 2.4386E-15 36533000 18403000 18130000 5487 IPI:IPI00796038.1;IPI:IPI00434965.1;IPI:IPI00877018.1;IPI:IPI00434966.1;IPI:IPI00877082.1 ADP-ribosylation factor-like protein 6-interacting protein 4;SR-15;SRp25;SR-25;HSP-975;HSVI-binding protein ARL6IP4 Q66PJ3-1;Q66PJ3;Q66PJ3-2;Q66PJ3-3;Q66PJ3-4 ENST00000315580;ENST00000392433;ENST00000392435 5 0.53225 1.3057 0.525 0.72107 0.84441 0.66951 PseudoU_synth_2 binding;catalytic activity;intramolecular transferase activity;isomerase activity;nucleic acid binding;pseudouridine synthase activity;RNA binding cellular biopolymer metabolic process;cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;pseudouridine synthesis;RNA metabolic process;RNA modification 2 2 2 7 7 7 37.533 1.8428E-17 9476300 5560700 3915600 5488 IPI:IPI00796048.3;IPI:IPI00916988.1;IPI:IPI00953398.1 RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Q6P087-1;Q6P087;Q6P087-2;Q6P087-3 ENST00000287624;ENST00000383820;ENST00000397234 3 1.0264 NaN NaN 1.2692 NaN NaN fn3;ig;I-set;Y_phosphatase cell part;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part binding;catalytic activity;phosphoprotein phosphatase activity;protein binding;protein tyrosine phosphatase activity;receptor activity;signal transducer activity;transmembrane receptor activity;transmembrane receptor protein tyrosine phosphatase activity cell communication;cell surface receptor linked signal transduction;phosphate metabolic process;phosphorus metabolic process;protein amino acid dephosphorylation;protein modification process;signal transduction 5 4 4 3.3 2.7 2.7 214.76 5.4327E-12 3727100 1844400 1882700 5489 IPI:IPI00852829.1;IPI:IPI00796452.2;IPI:IPI00219860.3;IPI:IPI00107831.4;IPI:IPI00465186.3 Receptor-type tyrosine-protein phosphatase delta PTPRD P23468-1;P23468;P23468-2 ENST00000346816;ENST00000360074;ENST00000381196 5 0.59173 1.2822 0.4972 0.8089 0.7997 0.70951 Death;TIR cell part;cytoplasm;intracellular part;intrinsic to membrane;membrane part binding;cytokine receptor binding;death receptor binding;molecular transducer activity;protein binding;receptor activity;receptor binding;signal transducer activity;transmembrane receptor activity;tumor necrosis factor receptor superfamily binding defense response;immune response;immune system process;inflammatory response;positive regulation of signal transduction;regulation of signal transduction;response to external stimulus;response to stress;response to wounding Apoptosis;Toll-like receptor signaling pathway 5 5 5 22.4 22.4 22.4 34.097 1.821E-31 40288000 22169000 18119000 5490 IPI:IPI00796856.1 Myeloid differentiation primary response protein MyD88 MYD88 Q99836 ENST00000396334 K04729 1 0.57166 1.4657 0.69545 0.73568 1.039 0.91941 DUF1981 binding cellular process;endosome transport;establishment of protein localization;Golgi to endosome transport;Golgi vesicle transport;intracellular transport;post-Golgi vesicle-mediated transport;protein transport;transport;vesicle-mediated transport 7 7 7 4.1 4.1 4.1 190.48 9.049E-19 31703000 17316000 14387000 5492 IPI:IPI00855820.1;IPI:IPI00797186.1;IPI:IPI00797469.2;IPI:IPI00183974.2 Protein MON2 homolog;Protein SF21 MON2;KIAA1040;SF21 Q7Z3U7-1;Q7Z3U7;Q7Z3U7-4;Q7Z3U7-2 ENST00000261188;ENST00000280379;ENST00000393632 4 0.82084 1.3605 0.54639 1.089 0.92414 0.65856 Alg6_Alg8 cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part catalytic activity;glucosyltransferase activity;transferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring hexosyl groups carbohydrate metabolic process;cellular biopolymer metabolic process;cellular process;metabolic process;protein amino acid glycosylation;protein amino acid N-linked glycosylation;protein metabolic process;protein modification process N-Glycan biosynthesis 2 2 2 4.9 4.9 4.9 58.18 4.2279E-42 27524000 14149000 13375000 5493 IPI:IPI00797222.1 Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase;Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase;Asparagine-linked glycosylation protein 6 ALG6;My046 Q9Y672 ENST00000263440;ENST00000371108;ENST00000405765 K03848 1 0.76376 1.4868 0.74257 0.98184 0.98202 0.97348 TIM cell part;cytoplasmic part;cytosol;intracellular part catalytic activity;intramolecular oxidoreductase activity;intramolecular oxidoreductase activity, interconverting aldoses and ketoses;isomerase activity;triose-phosphate isomerase activity alcohol metabolic process;carbohydrate metabolic process;generation of precursor metabolites and energy;glucose catabolic process;glucose metabolic process;monosaccharide metabolic process;organic acid metabolic process;pyruvate metabolic process Carbon fixation in photosynthetic organisms;Fructose and mannose metabolism;Glycolysis / Gluconeogenesis;Inositol phosphate metabolism 20 20 20 83.1 83.1 83.1 26.669 0 9324200000 4932000000 4392200000 5494 IPI:IPI00797270.4;IPI:IPI00451401.3;IPI:IPI00844224.2 Triosephosphate isomerase;Triose-phosphate isomerase TPI1;TPI P60174-1;P60174;P60174-2 ENST00000229270;ENST00000382270;ENST00000396705 K01803 3 0.72419 1.5446 0.64451 0.91457 0.96956 0.89097 Ank;KH_1 cell part;cytoplasm;intracellular part binding;nucleic acid binding;protein binding;RNA binding 22 10 10 11.4 5.3 5.3 278.74 0 59954000 31670000 28283000 5495 IPI:IPI00815707.3;IPI:IPI00797397.1;IPI:IPI00556571.3;IPI:IPI00871927.1;IPI:IPI00410680.4 Ankyrin repeat and KH domain-containing protein 1;Multiple ankyrin repeats single KH domain;HIV-1 Vpr-binding ankyrin repeat protein ANKHD1;KIAA1085;MASK;VBARP;PP2500 Q8IWZ3-4;Q8IWZ3;Q8IWZ3-1 ENST00000297183;ENST00000360839 5 0.78265 1.4534 0.78282 1.0165 0.96359 1.0032 CS immune response;immune system process;response to stimulus 14 14 14 28.3 28.3 28.3 66.775 9.2228E-78 516820000 274120000 242710000 5496 IPI:IPI00797537.2;IPI:IPI00306398.7;IPI:IPI00789225.2 NudC domain-containing protein 1;Chronic myelogenous leukemia tumor antigen 66;Tumor antigen CML66 NUDCD1;CML66 Q96RS6-1;Q96RS6;Q96RS6-2;Q96RS6-3 ENST00000239690 3 0.81226 1.7162 0.758 1.1297 1.1472 1.0186 AT_hook binding;DNA binding;nucleic acid binding 11 11 11 5 5 5 330.46 5.676E-213 36841000 18192000 18649000 5497 IPI:IPI00797574.3 Protein FAM44A FAM44A;KIAA1327 Q8NFC6 ENST00000040738 1 0.50039 1.0114 0.47025 0.64198 0.65826 0.6029 PHD;ubiquitin;YDG_SRA cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;cation binding;DNA binding;ion binding;ligase activity;nucleic acid binding;protein binding;RNA polymerase II transcription factor activity;transcription factor activity;transcription regulator activity;zinc ion binding DNA metabolic process;DNA repair;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;proteolysis;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 15 15 14 23.1 23.1 21.8 89.813 5.3052E-79 382150000 212670000 169480000 5499 IPI:IPI00797945.1 E3 ubiquitin-protein ligase UHRF1;Ubiquitin-like PHD and RING finger domain-containing protein 1;Ubiquitin-like-containing PHD and RING finger domains protein 1;Inverted CCAAT box-binding protein of 90 kDa;Transcription factor ICBP90;Nuclear zinc finger protein Np95;HuNp95;RING finger protein 106 UHRF1;ICBP90;NP95;RNF106 Q96T88 ENST00000262952;ENST00000398240 K10638 1 NaN 2.8609 0.56948 NaN 1.7592 0.74019 GBP;GBP_C cell part;integral to membrane;intrinsic to membrane;membrane part binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleotide binding;pyrophosphatase activity immune response;immune system process;response to stimulus 3 2 2 7.1 5.7 5.7 68.113 5.3129E-14 1318300 774410 543900 5500 IPI:IPI00798277.1 Guanylate-binding protein 3;Guanine nucleotide-binding protein 3;GTP-binding protein 3 GBP3 Q9H0R5 ENST00000370481;ENST00000394662 1 0.62654 1.2494 1.0138 0.87629 0.80124 1.3111 UMPH-1 cell part;cytoplasmic part;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle 2'-phosphotransferase activity;5'-nucleotidase activity;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;magnesium ion binding;nucleotidase activity;nucleotide binding;phosphatase activity;transferase activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside metabolic process;nucleoside phosphate metabolic process;pyrimidine nucleoside metabolic process Nicotinate and nicotinamide metabolism;Purine metabolism;Pyrimidine metabolism 8 8 8 30.1 30.1 30.1 37.948 5.1981E-46 195970000 78684000 117290000 5501 IPI:IPI00807412.1;IPI:IPI00619911.1;IPI:IPI00100192.4;IPI:IPI00647805.1 Cytosolic 5'-nucleotidase 3;Cytosolic 5'-nucleotidase III;Pyrimidine 5'-nucleotidase 1;Uridine 5'-monophosphate hydrolase 1;p36 NT5C3;P5N1;UMPH1;HSPC233 Q9H0P0-4;Q9H0P0;Q9H0P0-1;Q9H0P0-2;Q9H0P0-3 ENST00000242210;ENST00000381626;ENST00000396152;ENST00000405342 K01081 4 NaN 0.63631 2.2963 NaN 0.44363 3.0745 binding;protein binding 3 3 3 2.5 2.5 2.5 142.32 3.5007E-07 1864000 868330 995650 5502 IPI:IPI00807526.2 Uncharacterized protein C6orf167 C6orf167 Q6ZRQ5 ENST00000275053 1 0.57117 1.7789 NaN 0.8585 1.0393 NaN KH_1;ROKNT cell part;cytoplasm;heterogeneous nuclear ribonucleoprotein complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm;organelle part;ribonucleoprotein complex;spliceosomal complex binding;DNA binding;nucleic acid binding;protein binding;RNA binding nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 28 1 1 57 3 3 48.562 0 6227500 3884600 2342900 5504 IPI:IPI00807545.1 Heterogeneous nuclear ribonucleoprotein K;Transformation up-regulated nuclear protein HNRNPK;HNRPK P61978-3;P61978 ENST00000351839;ENST00000360384;ENST00000376258;ENST00000376263;ENST00000376281 1 0.62491 NaN NaN 0.78301 NaN NaN WD40 cytoplasmic part;cytosol;endosomal part;endosome membrane;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;organelle;organelle membrane;organelle part 2 1 1 4.7 1.9 1.9 48.564 3.3347E-05 64795 36170 28625 5505 IPI:IPI00807730.1 WD repeat-containing protein 44;Rabphilin-11 WDR44 Q5JSH3-3;Q5JSH3 ENST00000254029 1 NaN 1.6762 0.80732 NaN 1.0968 1.0674 Cofilin_ADF actin cytoskeleton;cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle actin binding;binding;catalytic activity;cytoskeletal protein binding;kinase activity;protein binding;protein kinase activity;protein tyrosine kinase activity;transferase activity;transferase activity, transferring phosphorus-containing groups cellular biopolymer metabolic process;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process 4 3 3 8.3 6.5 6.5 43.917 1.7649E-123 39944000 21255000 18689000 5506 IPI:IPI00183508.3;IPI:IPI00815767.1;IPI:IPI00816829.2 Twinfilin-1;Protein A6;Protein tyrosine kinase 9 TWF1;PTK9 Q12792-2;Q12792;Q12792-3;Q12792-4 ENST00000325127;ENST00000334878;ENST00000395510 K08870 3 1.3728 2.418 1.4409 1.8678 1.6065 1.8329 PX cell part;cytoplasm;intracellular part binding;enzyme binding;lipid binding;phosphatase binding;phosphoinositide binding;phospholipid binding;protein binding;protein phosphatase binding cell communication;cellular component organization;cellular process;endocytosis;establishment of localization;establishment of protein localization;membrane invagination;membrane organization;protein transport;transport;vesicle-mediated transport 10 10 9 50 50 45.7 18.762 1.041E-47 800970000 377290000 423680000 5507 IPI:IPI00815770.2;IPI:IPI00552276.5;IPI:IPI00216508.3;IPI:IPI00029740.2 Sorting nexin-3;Protein SDP3 SNX3 O60493-1;O60493;O60493-4;O60493-2;O60493-3 ENST00000230085;ENST00000349379;ENST00000368982 4 0.85157 1.6475 0.86678 1.1477 1.1127 1.1301 Septin actin filament bundle;actomyosin;condensed chromosome kinetochore;intracellular organelle;kinetochore;macromolecular complex;membrane-bounded organelle;non-membrane-bounded organelle;nucleus;organelle;septin complex;spindle;stress fiber binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;protein binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding;structural molecule activity anatomical structure formation;cell cycle phase;cell cycle process;cellular component assembly;cellular component organization;cellular process;cytokinesis;mitosis;nuclear division;organelle organization;protein complex assembly 22 22 22 48.4 48.4 48.4 50.808 0 1681700000 882060000 799630000 5508 IPI:IPI00941534.1;IPI:IPI00816201.1;IPI:IPI00900267.1 Septin-7;CDC10 protein homolog SEPT7;CDC10 Q16181-1;Q16181;Q16181-2 ENST00000350320 3 NaN 1.0139 NaN NaN 0.71184 NaN cell part;membrane;plasma membrane binding 2 2 2 3.8 3.8 3.8 92.923 0.0011661 317960 157080 160880 5509 IPI:IPI00470711.4;IPI:IPI00816614.1;IPI:IPI00470468.3 Protein EFR3 homolog A;Protein EFR3-like EFR3A;KIAA0143 Q14156-1;Q14156;Q14156-2;Q14156-3 ENST00000254624;ENST00000407309 3 0.80349 1.57 0.79077 1.0829 1.022 1.0668 DUF1777;zf-CCCH binding;cation binding;ion binding;metal ion binding;nucleic acid binding;nucleotide binding;RNA binding;transition metal ion binding;zinc ion binding 13 13 12 11.2 11.2 10 113.6 1.86E-162 100390000 55834000 44553000 5510 IPI:IPI00942458.1;IPI:IPI00827541.1;IPI:IPI00329545.7;IPI:IPI00795335.2;IPI:IPI00646837.3;IPI:IPI00032188.3 RNA-binding protein 26;RNA-binding motif protein 26;CTCL tumor antigen se70-2 RBM26;C13orf10;PRO1777 Q5T8P6-1;Q5T8P6;Q5T8P6-2;Q5T8P6-3;Q5T8P6-4;Q5T8P6-5 ENST00000267229;ENST00000327303 6 0.85759 1.444 0.88271 1.0644 1.0256 1.1807 Ras cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;protein binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding biological regulation;cell communication;cellular process;intracellular signaling cascade;regulation of biological process;regulation of cellular process;signal transduction;small GTPase mediated signal transduction 6 6 6 9.5 9.5 9.5 79.635 5.1169E-26 17763000 10082000 7680900 5512 IPI:IPI00827967.1;IPI:IPI00827972.1;IPI:IPI00514853.2;IPI:IPI00827825.1;IPI:IPI00827874.1 Putative GTP-binding protein Parf;Partner of ARF PARF;C9orf86 Q3YEC7-2;Q3YEC7;Q3YEC7-1;Q3YEC7-3 ENST00000311502;ENST00000371663;ENST00000371673;ENST00000371675 5 0.52516 1.0729 0.5123 0.68474 0.70566 0.67308 zf-C3HC4 binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleotide binding;protein binding;pyrophosphatase activity;zinc ion binding 102 102 101 22.9 22.9 22.8 596.48 0 1526000000 869300000 656660000 5513 IPI:IPI00828098.2;IPI:IPI00218094.3;IPI:IPI00642126.4;IPI:IPI00217287.3;IPI:IPI00470478.5;IPI:IPI00187159.8 RING finger protein 213 RNF213;C17orf27;KIAA1554 Q63HN8-1;Q63HN8 ENST00000336301 6 1.1646 2.1138 1.1728 1.562 1.3561 1.5045 CS;SGS;TPR_1 chromosomal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;kinetochore;macromolecular complex;non-membrane-bounded organelle;organelle;organelle part;protein complex;ubiquitin ligase complex binding catabolic process;cellular component organization;cellular process;macromolecule catabolic process;metabolic process;mitosis;modification-dependent protein catabolic process;nuclear division;organelle organization;protein metabolic process;proteolysis 21 21 21 57 57 57 41.024 0 2044000000 1010100000 1034000000 5514 IPI:IPI00828150.1;IPI:IPI00791573.1 Suppressor of G2 allele of SKP1 homolog;Sgt1;Putative 40-6-3 protein SUGT1 Q9Y2Z0-1;Q9Y2Z0;Q9Y2Z0-2 ENST00000343788 2 0.79443 1.5043 0.83407 1.0314 1.0168 1.027 DUF618;RRM_1 binding;nucleic acid binding;nucleotide binding;RNA binding 10 10 8 9.9 9.9 8.4 140.52 7.5341E-120 114780000 61309000 53467000 5516 IPI:IPI00829652.1 Putative RNA-binding protein 16;RNA-binding motif protein 16 RBM16;KIAA1116 Q9UPN6 ENST00000367178 1 0.54237 1.449 0.68317 0.72034 0.91561 0.88201 LEM cell part;cytoplasm;envelope;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane part;nuclear envelope;nuclear part;organelle envelope;organelle part 9 9 9 14.7 14.7 14.7 104.11 1.3139E-88 20361000 11255000 9105900 5517 IPI:IPI00829741.2;IPI:IPI00329245.8 Ankyrin repeat and LEM domain-containing protein 2 ANKLE2;KIAA0692 Q86XL3-1;Q86XL3;Q86XL3-2 ENST00000357997 2 0.90883 1.7382 0.68475 1.1876 1.1075 0.92435 Sec10 cell part;cytoplasm;intracellular part cellular process;establishment of protein localization;exocytosis;Golgi vesicle transport;intracellular transport;membrane docking;post-Golgi vesicle-mediated transport;protein transport;secretion;secretion by cell;transport;vesicle-mediated transport 13 13 13 21.5 21.5 21.5 81.852 1.808E-65 142240000 74798000 67439000 5518 IPI:IPI00829808.1 Exocyst complex component 5;Exocyst complex component Sec10 EXOC5;SEC10;SEC10L1 O00471 ENST00000340918 1 1.5282 1.5042 1.8557 2.2077 0.90942 2.7093 G-patch cell part;intracellular binding;nucleic acid binding 3 3 3 4.9 4.9 4.9 50.381 3.1454E-14 11623000 5573300 6050100 5519 IPI:IPI00829835.2;IPI:IPI00445571.3 G patch domain-containing protein 4 GPATCH4;GPATC4 Q5T3I0-1;Q5T3I0;Q5T3I0-2 ENST00000334588;ENST00000368229 2 0.8775 NaN NaN 1.1135 NaN NaN RhoGAP cell part;intracellular enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity biological regulation;cell communication;cellular process;regulation of biological process;regulation of cellular process;signal transduction 3 3 2 3.9 3.9 2.8 118.59 1.2737E-05 4311300 2100800 2210500 5520 IPI:IPI00830067.1;IPI:IPI00619938.2;IPI:IPI00376321.3;IPI:IPI00829903.1 Rho GTPase-activating protein 30;Rho-type GTPase-activating protein 30 ARHGAP30 Q7Z6I6-1;Q7Z6I6;Q7Z6I6-3;Q7Z6I6-2;Q7Z6I6-4 ENST00000368013;ENST00000368016 4 0.70072 1.5027 0.69972 0.9439 0.99649 0.86966 DnaJ;Myb_DNA-binding cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;heat shock protein binding;nucleic acid binding;protein binding;unfolded protein binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 16 16 16 34.6 34.6 34.6 71.896 4.595E-92 242620000 130330000 112300000 5521 IPI:IPI00830108.1;IPI:IPI00455199.2 DnaJ homolog subfamily C member 2;Zuotin-related factor 1;M-phase phosphoprotein 11 DNAJC2;MPHOSPH11;MPP11;ZRF1 Q99543-1;Q99543;Q99543-2 ENST00000249270;ENST00000379263 K09522 2 0.75312 1.5279 0.75415 0.98208 1.0222 0.98151 HEAT;IBN_N cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;organelle part;pore complex;protein complex binding;nuclear localization sequence binding;peptide binding;protein binding;protein transporter activity;signal sequence binding;substrate-specific transporter activity;transporter activity anatomical structure formation;cellular component organization;cellular process;intracellular protein transport;protein complex assembly;protein import into nucleus, docking;protein import into nucleus, translocation;protein transport;transport 25 25 20 31.7 31.7 27.1 102.35 0 2120000000 1126500000 993490000 5522 IPI:IPI00024364.2;IPI:IPI00843876.1;IPI:IPI00908817.2 Transportin-1;Importin beta-2;Karyopherin beta-2;M9 region interaction protein TNPO1;KPNB2;MIP1;TRN Q92973-1;Q92973;Q92973-2;Q92973-3 ENST00000337273;ENST00000396346 3 0.89652 1.346 NaN 1.1097 0.95325 NaN Cohesin_load extracellular region binding 2 2 1 11.5 11.5 4.6 24.654 1.0796E-14 2348000 1317700 1030200 5524 IPI:IPI00843937.1 Uncharacterized protein KIAA0892 KIAA0892 Q9Y6X3-2;Q9Y6X3 ENST00000262815;ENST00000392313 K11266 1 0.76841 1.4924 0.69699 1.0207 0.98412 0.99221 ERM;FERM_C;FERM_M;FERM_N actin filament;apical plasma membrane;cell projection;cell projection membrane;cortical cytoskeleton;cytoskeleton;cytosol;extrinsic to membrane;filopodium;leading edge membrane;microvillus membrane;non-membrane-bounded organelle;organelle;ruffle membrane actin binding;actin filament binding;binding;cell adhesion molecule binding;cytoskeletal protein binding;protein binding actin filament organization;anatomical structure formation;cell adhesion;cellular process;cytoskeletal anchoring at plasma membrane;cytoskeleton organization;leukocyte adhesion;organelle organization;regulation of cell shape Leukocyte transendothelial migration;Regulation of actin cytoskeleton 37 26 25 57.7 43.7 42.3 69.412 1.9051E-304 2116300000 1110300000 1005900000 5525 IPI:IPI00843975.1 Ezrin;p81;Cytovillin;Villin-2 EZR;VIL2 P15311 ENST00000337147;ENST00000367075;ENST00000392177 K08007 1 0.88073 1.6914 0.91179 1.1782 1.1414 1.1958 DUF2042 binding;protein binding 23 23 23 33.4 33.4 33.4 89.594 3.4951E-301 500900000 260340000 240560000 5526 IPI:IPI00844000.1 UPF0555 protein KIAA0776 KIAA0776 O94874 ENST00000369278 1 0.49244 1.1531 0.57775 0.66112 0.7165 0.86618 DUF171 3 3 3 9 9 9 42.008 5.9338E-20 13059000 5298800 7760100 5527 IPI:IPI00844014.1 Uncharacterized protein C9orf114 C9orf114 Q5T280 ENST00000361256;ENST00000372618 K09142 1 NaN 1.2767 NaN NaN 0.82559 NaN Ubiq_cyt_C_chap cell part;cytoplasmic part;cytoplasmic vesicle;intracellular organelle;intracellular part;organelle;vesicle 3 3 3 10.4 10.4 10.4 34.572 1.1526E-12 3001100 1491400 1509700 5529 IPI:IPI00844050.1;IPI:IPI00219889.2;IPI:IPI00396970.2;IPI:IPI00748809.1 Ubiquinol-cytochrome c reductase complex chaperone CBP3 homolog;Basic FGF-repressed Zic-binding protein UQCC;BZFB;C20orf44 Q9NVA1-1;Q9NVA1;Q9NVA1-2;Q9NVA1-4 ENST00000349714;ENST00000374381;ENST00000374385;ENST00000397556 4 0.57933 1.2613 0.13859 0.80057 0.84863 0.1786 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;DNA binding;ion binding;nucleic acid binding;protein binding;transcription cofactor activity;transcription corepressor activity;transcription factor binding;transcription regulator activity;transcription repressor activity;zinc ion binding negative regulation of transcription from RNA polymerase II promoter;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 2 2 2 28.4 28.4 28.4 15.199 4.1922E-05 79135000 54605000 24530000 5530 IPI:IPI00844193.2 Zinc finger protein 593;Zinc finger protein T86 ZNF593 O00488 ENST00000270812;ENST00000374266;ENST00000407889 1 0.78784 1.6575 0.87226 1.0934 1.0471 1.1564 DUF1716 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;enzyme binding;protein binding apoptosis;cell death;cellular process;death;immune system process;positive regulation of cell death;programmed cell death;regulation of cell death;somatic diversification of immune receptors;somatic diversification of immunoglobulins 11 11 11 19.9 19.9 19.9 65.173 4.4972E-283 169380000 88416000 80962000 5531 IPI:IPI00844214.1;IPI:IPI00472981.3;IPI:IPI00645320.1 Beta-catenin-like protein 1;Nuclear-associated protein;Testis development protein NYD-SP19 CTNNBL1;C20orf33;PP8304 Q8WYA6-1;Q8WYA6;Q8WYA6-2;Q8WYA6-3 ENST00000361383;ENST00000405275 3 0.7867 1.6274 0.8051 1.0375 1.0591 1.0611 efhand;efhand_Ca_insen;SH3_1;Spectrin cell cortex part;cell fraction;cell part;cytoplasmic part;cytoskeletal part;cytosol;insoluble fraction;intracellular organelle part;intracellular part;membrane fraction;organelle part;spectrin actin binding;binding;calcium ion binding;calmodulin binding;cation binding;cytoskeletal protein binding;ion binding;metal ion binding;protein binding;structural constituent of cytoskeleton;structural molecule activity negative regulation of macromolecule metabolic process;negative regulation of metabolic process;negative regulation of organelle organization;regulation of actin polymerization or depolymerization;regulation of metabolic process 135 135 1 54.7 54.7 0.7 284.54 0 9443500000 4873200000 4570300000 5532 IPI:IPI00844215.1;IPI:IPI00843765.1 Spectrin alpha chain, brain;Spectrin, non-erythroid alpha chain;Alpha-II spectrin;Fodrin alpha chain SPTAN1;SPTA2 Q13813-1;Q13813;Q13813-3 ENST00000358161;ENST00000372719;ENST00000372731 K06114 2 NaN NaN 0.61973 NaN NaN 0.84208 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 2 2 2 11.1 11.1 11.1 25.977 5.1616E-43 33681000 18816000 14865000 5533 IPI:IPI00844507.2 UPF0688 protein C1orf174 C1orf174 Q8IYL3 ENST00000361605;ENST00000378200 1 0.64964 1.2444 0.66996 0.84847 0.84825 0.82523 DEAD;dsrm;DUF1605;HA2;Helicase_C centrosome;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;microtubule organizing center;non-membrane-bounded organelle;nucleolus;organelle;organelle part;ribonucleoprotein complex ATP-dependent DNA helicase activity;catalytic activity;DNA binding;DNA helicase activity;double-stranded RNA binding;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;RNA binding;RNA helicase activity nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 53 53 53 46.5 46.5 46.5 140.96 0 7995700000 4233200000 3762500000 5534 IPI:IPI00844578.1 ATP-dependent RNA helicase A;Nuclear DNA helicase II;DEAH box protein 9 DHX9;DDX9;LKP;NDH2 Q08211 ENST00000367549 1 1.2567 NaN 0.31758 1.562 NaN 0.39526 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cell cycle;cellular process 3 3 3 3.7 3.7 3.7 104.99 6.7453E-10 2361400 1396500 964990 5535 IPI:IPI00845273.1;IPI:IPI00816121.3;IPI:IPI00903029.1 Protein URG4;HBV X protein up-regulated gene 4 protein;HBxAg up-regulated gene 4 protein URG4;KIAA1507 Q8TCY9-1;Q8TCY9;Q8TCY9-2;Q8TCY9-3 ENST00000223341;ENST00000336086;ENST00000398990;ENST00000402306 3 0.72582 1.5157 0.71314 0.95721 0.97314 0.94815 AT_hook;HEAT cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle adenyl nucleotide binding;ATP binding;binding;DNA binding;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding cell cycle process;cell proliferation;cellular component organization;cellular process;mitotic sister chromatid cohesion;negative regulation of cell proliferation;organelle organization;regulation of cell proliferation;sister chromatid cohesion 39 39 35 26.9 26.9 24.2 164.67 0 808090000 438990000 369110000 5536 IPI:IPI00937545.1;IPI:IPI00845446.2;IPI:IPI00845459.1;IPI:IPI00845253.1;IPI:IPI00845353.2 Sister chromatid cohesion protein PDS5 homolog B;Androgen-induced proliferation inhibitor;Androgen-induced prostate proliferative shutoff-associated protein AS3 PDS5B;APRIN;AS3;KIAA0979 Q9NTI5-1;Q9NTI5;Q9NTI5-2 ENST00000315596;ENST00000400481 K11267 5 NaN 1.4842 NaN NaN 0.94302 NaN cell part;integral to membrane;intrinsic to membrane;membrane part 2 2 2 4.3 4.3 4.3 59.659 7.8583E-05 1150200 594680 555540 5537 IPI:IPI00845516.1;IPI:IPI00396658.3 Protein ITFG3 ITFG3;C16orf9 Q9H0X4-1;Q9H0X4;Q9H0X4-2 ENST00000301678;ENST00000399932 2 NaN 1.4859 NaN NaN 0.95981 NaN C2;efhand_like;PH;PI-PLC-X;PI-PLC-Y cell part;cytoplasm;intracellular part binding;calcium ion binding;catalytic activity;inositol or phosphatidylinositol phosphodiesterase activity;phosphoinositide phospholipase C activity;phospholipase activity;phospholipase C activity;signal transducer activity biological regulation;cell communication;cellular process;intracellular signaling cascade;lipid metabolic process;metabolic process;primary metabolic process;regulation of biological process;regulation of cellular process;signal transduction 3 3 3 3.8 3.8 3.8 125.86 4.3838E-25 824470 481090 343390 5539 IPI:IPI00847504.1;IPI:IPI00010334.5;IPI:IPI00789859.2 Inactive phospholipase C-like protein 2;Phospholipase C epsilon 2 PLCL2;KIAA1092;PLCE2 Q9UPR0-1;Q9UPR0;Q9UPR0-3;Q9UPR0-2 ENST00000285094 3 0.77413 1.2894 0.74399 1.0082 0.84669 0.95014 WD40 cell part;membrane;plasma membrane binding;enzyme binding;phosphatase binding;protein binding;protein phosphatase binding;receptor binding 22 22 22 66.2 66.2 66.2 35.076 0 13911000000 7224600000 6686500000 5543 IPI:IPI00848226.1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-like protein 12.3;Receptor of activated protein kinase C 1;Receptor for activated C kinase;Cell proliferation-inducing gene 21 protein;Human lung cancer oncogene 7 protein GNB2L1;HLC7;PIG21 P63244 ENST00000376817;ENST00000389599 1 0.68059 1.514 0.76654 0.99711 0.9588 1.0143 YjeF_N extracellular region binding;protein binding 4 4 4 16 16 16 31.674 2.3596E-20 34743000 19387000 15357000 5544 IPI:IPI00941988.1;IPI:IPI00848298.1 Apolipoprotein A-I-binding protein;YjeF N-terminal domain-containing protein 1 APOA1BP;AIBP;YJEFN1 Q8NCW5-1;Q8NCW5;Q8NCW5-2 ENST00000368235 2 0.94286 1.6675 1.0821 1.2956 1.1306 1.4892 binding;nucleic acid binding;RNA binding 4 4 4 6.5 6.5 6.5 129.98 1.2077E-16 70018000 36965000 33053000 5545 IPI:IPI00852584.3 RNA-binding protein 33;RNA-binding motif protein 33;Proline-rich protein 8 RBM33;PRR8 Q96EV2-1;Q96EV2 ENST00000287912;ENST00000307403;ENST00000392761 1 0.09832 8.9389 NaN 0.12172 6.2268 NaN zf-C2H2 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;transition metal ion binding;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription + 3 2 2 2.3 1.6 1.6 124.29 0.00030639 1876900 395810 1481100 5546 IPI:IPI00852669.1 Zinc finger protein 516 ZNF516;KIAA0222 Q92618 ENST00000217537 1 0.77167 1.496 0.80325 1.0717 0.95513 1.053 Drf_DAD;Drf_FH1;Drf_FH3;Drf_GBD;FH2 cell projection membrane;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;leading edge membrane;membrane part;non-membrane-bounded organelle;organelle;plasma membrane part;ruffle membrane actin binding;binding;cytoskeletal protein binding;enzyme binding;GTPase binding;protein binding;Ras GTPase binding;receptor binding;Rho GTPase binding;small GTPase binding actin cytoskeleton organization;actin filament-based process;cellular component organization;cellular process;cytoskeleton organization;multicellular organismal process;organelle organization;sensory perception;sensory perception of sound;system process 36 36 36 31.7 31.7 31.7 141.35 0 2079600000 1084000000 995570000 5547 IPI:IPI00852685.1;IPI:IPI00884341.2 Protein diaphanous homolog 1;Diaphanous-related formin-1 DIAPH1;DIAP1 O60610-1;O60610;O60610-2 ENST00000253811;ENST00000398557 2 0.57897 1.5841 NaN 0.8028 1.0329 NaN CRAL_TRIO;CRAL_TRIO_N;Y_phosphatase cell part;cytoplasm;intracellular part binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;non-membrane spanning protein tyrosine phosphatase activity;phosphoprotein phosphatase activity;protein binding;protein tyrosine phosphatase activity cellular biopolymer metabolic process;cellular process;dephosphorylation;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid dephosphorylation;protein metabolic process;protein modification process 4 4 4 7.8 7.8 7.8 68.019 2.7352E-42 5379300 3620600 1758700 5548 IPI:IPI00852804.1 Tyrosine-protein phosphatase non-receptor type 9;Protein-tyrosine phosphatase MEG2 PTPN9 P43378 ENST00000306726 K01104 1 0.89908 1.67 0.92721 1.2267 1.0571 1.1953 SWIB cell part;chromatin remodeling complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex;SWI/SNF complex;SWI/SNF-type complex binding;protein binding;protein complex scaffold;structural molecule activity;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding;transcription regulator activity chromatin organization;chromatin remodeling;organelle organization;positive regulation of biosynthetic process;regulation of biosynthetic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent 10 7 6 21.2 14.8 13.4 58.232 1.0261E-73 51092000 26714000 24377000 5549 IPI:IPI00852816.1;IPI:IPI00853408.1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1;SWI/SNF complex 60 kDa subunit;60 kDa BRG-1/Brm-associated factor subunit A;BRG1-associated factor 60A SMARCD1;BAF60A Q96GM5-1;Q96GM5;Q96GM5-2 ENST00000228253;ENST00000347683;ENST00000394963 K11650 2 0.79191 1.2281 NaN 1.0169 0.88722 NaN UCH;zf-UBP cell part;histone acetyltransferase complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;SAGA complex;SAGA-type complex binding;catalytic activity;peptidase activity;protein binding;transcription coactivator activity;transcription cofactor activity;transcription factor binding;ubiquitin thiolesterase activity;ubiquitin-specific protease activity chromatin organization;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein modification process;proteolysis;regulation of transcription, DNA-dependent;transcription;ubiquitin-dependent protein catabolic process 3 3 3 5.7 5.7 5.7 59.96 3.657E-05 16615000 9129900 7485500 5550 IPI:IPI00852960.1;IPI:IPI00923593.1;IPI:IPI00399220.7 Ubiquitin carboxyl-terminal hydrolase 22;Ubiquitin thioesterase 22;Ubiquitin-specific-processing protease 22;Deubiquitinating enzyme 22 USP22;KIAA1063;USP3L Q9UPT9-1;Q9UPT9;Q9UPT9-2 ENST00000261497 K11366 3 0.87988 0.8603 0.89763 1.0471 0.54102 1.0834 Beach;WD40 binding 7 7 7 4.2 4.2 4.2 302.51 5.5776E-62 292200000 150330000 141870000 5551 IPI:IPI00894235.1;IPI:IPI00852973.2;IPI:IPI00432423.1;IPI:IPI00180515.3 Neurobeachin-like protein 2 NBEAL2;KIAA0540;UNQ253/PRO290 Q6ZNJ1-1;Q6ZNJ1;Q6ZNJ1-2 ENST00000292309;ENST00000296147;ENST00000383740 4 0.65545 NaN NaN 0.91771 NaN NaN DUF1897;KH_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;DNA binding;nucleic acid binding;protein binding;RNA binding;single-stranded DNA binding;structure-specific DNA binding;transcription factor activity;transcription regulator activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription;transcription from RNA polymerase II promoter;transcription, DNA-dependent 24 1 1 45.1 3.2 3.2 68.733 0 4194600 2434200 1760500 5552 IPI:IPI00853059.2 Far upstream element-binding protein 1;DNA helicase V;HDH V FUBP1 Q96AE4-2;Q96AE4 ENST00000370767;ENST00000370768;ENST00000370773 1 0.72522 1.4281 0.70905 0.89605 1.0332 0.8783 Bromo_TP;PHD cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex;transcription factor TFIID complex binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transition metal ion binding;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 3 3 3 3.2 3.2 3.2 103.58 6.6671E-05 4429000 2477700 1951300 5556 IPI:IPI00853240.1 Transcription initiation factor TFIID subunit 3;TBP-associated factor 3;Transcription initiation factor TFIID 140 kDa subunit;140 kDa TATA box-binding protein-associated factor;TAF140;TAFII140 TAF3 Q5VWG9 ENST00000344293 1 0.96538 1.6481 0.5964 1.3669 1.1097 0.8101 7 7 7 18.4 18.4 18.4 62.543 1.8212E-77 48327000 25716000 22611000 5557 IPI:IPI00853278.1 SLAIN motif-containing protein 2 SLAIN2;KIAA1458 Q9P270 ENST00000264313 1 0.72994 1.6601 0.93957 1.0358 1.1074 1.2332 FKBP_C axon;cell part;cell projection;cytoplasm;intracellular part;neuron projection biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 9 9 9 11.6 11.6 11.6 133.63 2.4648E-81 48484000 24143000 24341000 5558 IPI:IPI00853400.1;IPI:IPI00855962.1;IPI:IPI00646791.2 FK506-binding protein 15 FKBP15;KIAA0674 Q5T1M5-1;Q5T1M5;Q5T1M5-2 ENST00000238256 3 NaN NaN 1.4339 NaN NaN 1.7952 2 2 2 2.5 2.5 2.5 108.56 1.8703E-29 2036300 1002900 1033400 5559 IPI:IPI00853404.1 Uncharacterized protein KIAA0226 KIAA0226 Q92622 ENST00000296343 1 0.92082 1.2964 0.93564 1.2056 0.84448 1.2185 efhand cell part;cell projection;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;lamellipodium;membrane-bounded organelle;nucleus;organelle;ruffle binding;calcium ion binding;cation binding;enzyme inhibitor activity;enzyme regulator activity;ion binding;magnesium ion binding;phosphatase inhibitor activity;phosphatase regulator activity;protein binding;protein phosphatase regulator activity 3 3 3 12.4 12.4 12.4 30.289 6.7681E-111 39361000 19989000 19372000 5560 IPI:IPI00853505.1;IPI:IPI00791863.1 Tescalcin TESC Q96BS2-1;Q96BS2 ENST00000392545 2 0.71196 1.3597 0.68164 0.93023 0.9121 0.91003 HEAT cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;identical protein binding;protein binding cell cycle phase;cell cycle process;cell division;cellular component organization;cellular process;mitosis;nuclear division;organelle fission;organelle organization 34 30 30 29.7 26.8 26.8 150.83 0 764290000 409140000 355150000 5561 IPI:IPI00854642.1;IPI:IPI00854687.2 Sister chromatid cohesion protein PDS5 homolog A;Sister chromatid cohesion protein 112;Cell proliferation-inducing gene 54 protein PDS5A;KIAA0648;PDS5;PIG54 Q29RF7-1;Q29RF7 ENST00000303538 K11267 2 0.3876 0.52422 0.61346 0.4805 0.37169 0.75951 LLGL;WD40 cortical actin cytoskeleton;cortical cytoskeleton;cytoplasmic part;cytoskeletal part;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle;organelle part binding;enzyme binding;kinase binding;protein binding;protein kinase binding;structural molecule activity anatomical structure formation;cellular component assembly;cellular component organization;cellular process;cytoskeleton organization;exocytosis;organelle organization;protein complex assembly;transport;vesicle-mediated transport Tight junction 5 5 5 5.9 5.9 5.9 115.42 4.1354E-35 5327900 3257600 2070300 5563 IPI:IPI00854741.2 Lethal(2) giant larvae protein homolog 1;Human homolog to the D-lgl gene protein;Hugl-1;DLG4 LLGL1;DLG4;HUGL;HUGL1 Q15334 ENST00000316843 K06094 1 NaN 2.0194 NaN NaN 1.3957 NaN PWWP 2 2 2 3.6 3.6 3.6 81.959 8.1385E-05 1213400 954330 259030 5564 IPI:IPI00871452.1;IPI:IPI00855754.1 PWWP domain-containing protein 2A PWWP2A;KIAA1935;MST101 Q96N64-1;Q96N64;Q96N64-2 ENST00000307063 2 0.82783 1.1322 0.90835 1.0266 0.78362 1.1326 La binding;nucleic acid binding;RNA binding 5 1 1 17.1 4.6 4.6 33.364 1.6765E-36 77255000 34676000 42578000 5565 IPI:IPI00855786.1;IPI:IPI00855812.1;IPI:IPI00855721.1 La-related protein 2;La ribonucleoprotein domain family member 2 LARP2 Q659C4-5;Q659C4;Q659C4-6;Q659C4-7 ENST00000264584;ENST00000326639;ENST00000354456;ENST00000394288 3 2.2634 3.6707 2.1041 2.8655 2.3346 2.9159 cell part;cytoplasm;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;microtubule;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;DNA binding;nucleic acid binding cytokinesis;cytokinesis after mitosis;cytoskeleton organization;DNA packaging;microtubule cytoskeleton organization;microtubule-based process;mitotic chromosome condensation;organelle organization;regulation of mitosis;regulation of mitotic cell cycle 11 11 1 34.6 34.6 4.7 47.569 1.9672E-95 114970000 45550000 69421000 5566 IPI:IPI00855788.1 Nucleolar and spindle-associated protein 1 NUSAP1;ANKT;BM-037;PRO0310 Q9BXS6-4;Q9BXS6 ENST00000260359 1 0.75551 1.458 0.68968 0.92 0.99232 0.8958 5 5 5 51.9 51.9 51.9 9.0564 6.4967E-213 2386700000 1253100000 1133600000 5567 IPI:IPI00855846.1 UPF0727 protein C6orf115 C6orf115;HSPC280;PRO2013 Q9P1F3 ENST00000367660 1 0.80621 1.4745 0.81642 1.0575 0.97197 1.0528 RRM_1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;ribonucleoprotein complex binding;DNA binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding apoptosis;cell death;metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;RNA processing;RNA splicing;transcription 17 17 17 44.1 44.1 44.1 55.399 2.4953E-216 1901800000 905780000 996060000 5569 IPI:IPI00855912.1;IPI:IPI00100716.2;IPI:IPI00856076.1;IPI:IPI00788826.1;IPI:IPI00069750.2;IPI:IPI00797595.1 Poly(U)-binding-splicing factor PUF60;60 kDa poly(U)-binding-splicing factor;FUSE-binding protein-interacting repressor;Siah-binding protein 1;Ro-binding protein 1 PUF60;FIR;ROBPI;SIAHBP1 Q9UHX1-6;Q9UHX1;Q9UHX1-2;Q9UHX1-5;Q9UHX1-4;Q9UHX1-1;Q9UHX1-3 ENST00000313352;ENST00000349157 6 2.0956 4.3221 2.0293 2.8172 2.7031 2.5394 Cenp-F_leu_zip;Cenp-F_N;Rb-bdg_C_Cenp-F chromosomal part;cytoskeletal part;envelope;intracellular part;macromolecular complex;midbody;nuclear envelope;nuclear matrix;nuclear part;organelle envelope;organelle part;outer kinetochore of condensed chromosome;protein complex;spindle pole binding;chromatin binding;dynein binding;identical protein binding;protein binding;protein C-terminus binding;protein dimerization activity;protein homodimerization activity;transcription factor binding cell cycle checkpoint;DNA metabolic process;DNA replication;G2 phase of mitotic cell cycle;nitrogen compound metabolic process;nuclear division;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein complex assembly;transport 50 50 50 18.4 18.4 18.4 367.76 0 212580000 104790000 107790000 5570 IPI:IPI00855998.1 Centromere protein F;Kinetochore protein CENP-F;Mitosin;AH antigen CENPF P49454 K11499 1 0.66824 1.2096 0.65928 0.88435 0.81253 0.88484 Ribosomal_L22e cell part;cytoplasmic part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation Ribosome 4 3 3 45.9 39.3 39.3 14.606 1.0838E-33 265230000 136440000 128790000 5571 IPI:IPI00856049.1 60S ribosomal protein L22-like 1 RPL22L1 Q6P5R6 ENST00000295830 K02891 1 0.71873 NaN NaN 1.0623 NaN NaN JmjC;PHD cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding 2 1 1 2.6 1.4 1.4 120.77 4.9462E-53 1255200 675190 580000 5572 IPI:IPI00867617.6 PHD finger protein 2;GRC5 PHF2;KIAA0662 O75151 ENST00000359246 1 0.80435 1.6338 0.83824 0.98767 1.1324 1.0358 HECT cell part;intracellular acid-amino acid ligase activity;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;protein modification process;proteolysis 6 5 5 1.7 1.5 1.5 439.34 7.6863E-06 22421000 13436000 8985100 5573 IPI:IPI00869000.1;IPI:IPI00942832.1;IPI:REV_IPI00173642.1;IPI:REV_IPI00477038.1 Probable E3 ubiquitin-protein ligase KIAA0614 KIAA0614 Q9Y4D8-2;Q9Y4D8;Q9Y4D8-1 ENST00000377560 4 1.1466 2.4006 0.6011 1.5133 1.5337 0.80937 CARD cell part;cytoplasmic part;cytosol;intracellular part;membrane;membrane part;membrane raft;plasma membrane binding;catalytic activity;guanylate kinase activity;kinase activity;nucleotide kinase activity;phosphotransferase activity, phosphate group as acceptor;protein binding;transferase activity;transferase activity, transferring phosphorus-containing groups positive regulation of cytokine production;regulation of biosynthetic process;regulation of cell death;regulation of cytokine production;regulation of gene expression;regulation of macromolecule biosynthetic process B cell receptor signaling pathway;T cell receptor signaling pathway 5 5 5 4.8 4.8 4.8 133.28 2.8981E-14 4204700 2582000 1622700 5574 IPI:IPI00869011.2 Caspase recruitment domain-containing protein 11;CARD-containing MAGUK protein 3;Carma 1 CARD11;CARMA1 Q9BXL7 ENST00000355508;ENST00000396946 K07367 1 0.58555 1.3998 0.54135 0.76742 0.93614 0.71189 NUDIX cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;microbody;mitochondrion;organelle;peroxisome binding;catalytic activity;cation binding;hydrolase activity;ion binding;magnesium ion binding;manganese ion binding;metal ion binding;transition metal ion binding 5 5 5 17.1 17.1 17.1 42.233 3.8908E-15 56325000 33309000 23016000 5575 IPI:IPI00869107.1 Nucleoside diphosphate-linked moiety X motif 19, mitochondrial NUDT19 A8MXV4 ENST00000397061 1 0.60073 1.4457 0.65928 0.81122 0.92869 0.93992 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;nucleus;organelle binding;protein binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding;transcription regulator activity biosynthetic process;gamete generation;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;spermatogenesis;transcription 7 7 7 57.3 57.3 57.3 11.967 1.5232E-41 177660000 99785000 77873000 5576 IPI:IPI00871174.2 C-Myc-binding protein;Associate of Myc 1 MYCBP;AMY1 Q99417 ENST00000372993;ENST00000397572 1 0.73951 1.1356 0.79353 0.93033 0.7692 1.0062 3 2 2 11.6 8.8 8.8 36.275 5.5303E-07 8448300 4379600 4068700 5577 IPI:IPI00871376.1 GATS-like protein 3 GATSL3 Q8WTX7 ENST00000330168;ENST00000407689 1 0.69558 1.2666 0.61975 0.8933 0.80764 0.83563 Mov34 BRCA1-A complex;BRISC complex;cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nuclear ubiquitin ligase complex;organelle part;protein complex;ubiquitin ligase complex binding;catalytic activity;cysteine-type peptidase activity;hydrolase activity;metallopeptidase activity;peptidase activity;protein binding;ubiquitin thiolesterase activity;ubiquitin-specific protease activity;zinc ion binding cell cycle checkpoint;chromatin organization;DNA damage checkpoint;DNA metabolic process;DNA repair;double-strand break repair;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein modification process;regulation of DNA repair 6 6 6 25.4 25.4 25.4 33.149 6.3486E-70 133770000 66186000 67586000 5579 IPI:IPI00871617.1;IPI:IPI00939471.1;IPI:IPI00936224.2;IPI:IPI00929376.2;IPI:IPI00853631.2 Lys-63-specific deubiquitinase BRCC36;BRCA1-A complex subunit BRCC36;BRISC complex subunit BRCC36;BRCA1/BRCA2-containing complex subunit 3;BRCA1/BRCA2-containing complex subunit 36 BRCC3;BRCC36;C6.1A;CXorf53 P46736-2;P46736;P46736-1;P46736-3;P46736-4 ENST00000369462;ENST00000399042 K11864 5 0.91757 1.6847 0.677 1.1422 1.1596 0.85296 DDHD;SAM_1;WWE cell part;cytoplasm;intracellular part binding;catalytic activity;cation binding;hydrolase activity;ion binding;metal ion binding catabolic process;lipid catabolic process;lipid metabolic process;metabolic process;primary metabolic process 2 2 2 2.5 2.5 2.5 81.031 5.0362E-09 10858000 6055200 4802300 5580 IPI:IPI00871731.1 Phospholipase DDHD2;DDHD domain-containing protein 2;SAM, WWE and DDHD domain-containing protein 1 DDHD2;KIAA0725;SAMWD1 O94830 ENST00000397166 1 NaN 2.6242 1.2115 NaN 1.8978 1.579 cell part;cytoplasm;cytoplasmic microtubule;cytoskeletal part;intracellular organelle part;intracellular part;microtubule;organelle part cell communication;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;G2 phase of mitotic cell cycle;microtubule-based process;response to DNA damage stimulus;response to stress;signal transduction p53 signaling pathway 4 4 4 8.2 8.2 8.2 76.614 4.2223E-24 11346000 5759100 5587300 5582 IPI:IPI00871779.2 G2 and S phase-expressed protein 1;B99 homolog GTSE1 Q9NYZ3 ENST00000160874;ENST00000361934 K10129 1 0.78503 1.3251 0.80056 0.98974 0.93323 1.0002 RRM_1 binding;nucleic acid binding;nucleotide binding;RNA binding 7 7 7 7.7 7.7 7.7 118.1 8.4727E-82 55634000 29062000 26572000 5583 IPI:IPI00871780.1 RNA-binding protein 12B;RNA-binding motif protein 12B RBM12B Q8IXT5 ENST00000399300 1 0.84558 1.3868 0.84785 1.1036 0.91753 1.1159 HECT;WWE cell part;cytoplasmic part;cytosol;intracellular part;macromolecular complex;protein complex acid-amino acid ligase activity;binding;catalytic activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;protein binding;receptor binding;transcription factor binding;ubiquitin-protein ligase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;protein modification process;protein ubiquitination;proteolysis Ubiquitin mediated proteolysis 33 33 33 20.9 20.9 20.9 220.43 0 352860000 181950000 170910000 5584 IPI:IPI00871861.1 Probable E3 ubiquitin-protein ligase TRIP12;Thyroid receptor-interacting protein 12 TRIP12;KIAA0045 Q14669 ENST00000283943;ENST00000389044 K10590 1 0.34486 0.62988 0.13356 0.43428 0.43022 0.17561 C1_1;Pkinase;RBD ATP binding;binding;catalytic activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;receptor signaling protein activity;signal transducer activity cell communication;cellular process;intracellular signaling cascade;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein modification process;signal transduction Acute myeloid leukemia;Bladder cancer;Chronic myeloid leukemia;Colorectal cancer;Endometrial cancer;ErbB signaling pathway;Glioma;Insulin signaling pathway;Long-term depression;Long-term potentiation;Melanoma;Natural killer cell mediated cytotoxicity;Non-small cell lung cancer;Pancreatic cancer;Pathways in cancer;Progesterone-mediated oocyte maturation;Prostate cancer;Regulation of actin cytoskeleton;Renal cell carcinoma;Vascular smooth muscle contraction 7 7 3 15.7 15.7 8.4 67.585 1.022E-34 59842000 35049000 24793000 5585 IPI:IPI00872240.1 A-Raf proto-oncogene serine/threonine-protein kinase;A-raf-1;Proto-oncogene Pks ARAF;ARAF1;PKS;PKS2 P10398 ENST00000290277;ENST00000377045 K08845 1 0.79376 1.6476 0.84314 1.083 1.082 1.0941 Ras binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding biological regulation;cell communication;cellular process;intracellular signaling cascade;regulation of biological process;regulation of cellular process;signal transduction;small GTPase mediated signal transduction 6 6 6 39.8 39.8 39.8 20.48 1.1229E-146 76053000 41376000 34677000 5586 IPI:IPI00872292.1;IPI:IPI00879146.1 Putative GTP-binding protein RAY-like;Rab-like protein 4 RABL4;RAYL Q9BW83-1;Q9BW83;Q9BW83-2 ENST00000216198;ENST00000340630 K07934 2 0.9236 1.566 0.97479 1.1945 1.1029 1.1928 HD catalytic activity 9 9 9 57.4 57.4 57.4 23.39 6.7605E-156 590560000 306190000 284370000 5587 IPI:IPI00872352.1;IPI:IPI00386751.2;IPI:IPI00783518.2 HD domain-containing protein 2;Hepatitis C virus NS5A-transactivated protein 2 HDDC2;C6orf74;NS5ATP2;CGI-130 Q7Z4H3-1;Q7Z4H3;Q7Z4H3-2 ENST00000368377;ENST00000389000;ENST00000398153 K07023 3 0.84287 1.4535 1.2956 0.99659 0.98918 1.6344 EI24 cell part;integral to membrane;intrinsic to membrane;membrane part induction of apoptosis;induction of programmed cell death;negative regulation of cell growth;positive regulation of apoptosis;positive regulation of cell death;regulation of apoptosis;regulation of cell death;regulation of cell growth;regulation of growth p53 signaling pathway 2 2 2 5.3 5.3 5.3 40.979 0.001913 64439000 30776000 33662000 5588 IPI:IPI00872497.4 Etoposide-induced protein 2.4 homolog;p53-induced gene 8 protein EI24;PIG8 O14681 ENST00000278903;ENST00000397776 K10134 1 0.84304 1.8561 0.87685 1.1352 1.1901 1.1451 CoA_binding;Ligase_CoA cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part ATP citrate synthase activity;binding;catalytic activity;CoA-ligase activity;GTP binding;nucleotide binding;succinate-CoA ligase (ADP-forming) activity;succinate-CoA ligase (GDP-forming) activity;succinate-CoA ligase activity;transferase activity acetyl-CoA catabolic process;acetyl-CoA metabolic process;catabolic process;cellular catabolic process;cellular metabolic process;cellular process;coenzyme catabolic process;coenzyme metabolic process;metabolic process;tricarboxylic acid cycle Citrate cycle (TCA cycle);Propanoate metabolism 4 4 4 15.9 15.9 15.9 36.249 3.737E-49 394490000 205670000 188820000 5589 IPI:IPI00872762.2 Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial;Succinyl-CoA synthetase subunit alpha SUCLG1 P53597 ENST00000393868 K01899 1 0.8483 1.9101 1.0421 1.1458 1.2724 1.2891 Annexin cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle binding;calcium ion binding;calcium-dependent phospholipid binding;cation binding;enzyme inhibitor activity;enzyme regulator activity;ion binding;lipid binding;metal ion binding;phospholipase inhibitor activity;phospholipid binding anti-apoptosis;cell communication;cellular process;negative regulation of apoptosis;negative regulation of programmed cell death;regulation of apoptosis;regulation of cell death;regulation of programmed cell death;signal transduction 13 13 13 40.4 40.4 40.4 35.882 7.8051E-133 280160000 141150000 139020000 5590 IPI:IPI00872780.1 Annexin A4;Annexin-4;Annexin IV;Lipocortin IV;Endonexin I;Chromobindin-4;Protein II;P32.5;Placental anticoagulant protein II;PP4-X;35-beta calcimedin;Carbohydrate-binding protein p33/p41 ANXA4;ANX4 P09525 ENST00000355054;ENST00000394295 1 0.84634 1.8792 0.88571 1.1775 1.2056 1.2526 RRM_1;SVS_QK;zf-RanBP cell part;cell surface;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;calmodulin binding;cation binding;ion binding;metal ion binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding;transition metal ion binding;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 8 8 8 13.9 13.9 13.9 68.477 1.4131E-268 886080000 453160000 432920000 5591 IPI:IPI00872855.1;IPI:IPI00293254.1 RNA-binding protein EWS;EWS oncogene;Ewing sarcoma breakpoint region 1 protein EWSR1;EWS Q01844-1;Q01844;Q01844-2 ENST00000332050;ENST00000397938;ENST00000405024 2 0.8248 1.7741 0.14556 1.0954 1.1019 0.19026 Carb_kinase 12 12 12 35.7 35.7 35.7 36.576 7.811E-122 82514000 44900000 37614000 5592 IPI:IPI00873027.2;IPI:IPI00645172.1;IPI:IPI00940060.1 Carbohydrate kinase domain-containing protein CARKD Q8IW45-1;Q8IW45;Q8IW45-2 3 0.975 1.3558 0.85052 1.2273 0.95541 1.0564 4 4 4 12.2 12.2 12.2 41.685 4.7384E-10 22489000 11734000 10755000 5593 IPI:IPI00873040.1 WD repeat-containing protein 73 WDR73;HSPC264 Q6P4I2 ENST00000323189;ENST00000398528 1 NaN 1.2654 NaN NaN 0.82954 NaN Ago_hook centrosome;cytoplasmic mRNA processing body;Golgi apparatus;intracellular organelle;macromolecular complex;membrane-bounded organelle;microtubule organizing center;non-membrane-bounded organelle;nucleus;organelle;ribonucleoprotein complex binding;nucleic acid binding;nucleotide binding;RNA binding cellular process;negative regulation of macromolecule metabolic process;negative regulation of metabolic process;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of translation 2 2 2 1.9 1.9 1.9 195.4 4.2641E-14 689450 322250 367200 5594 IPI:IPI00940033.1;IPI:IPI00873067.1;IPI:IPI00152296.1 Trinucleotide repeat-containing gene 6B protein TNRC6B;KIAA1093 Q9UPQ9-3;Q9UPQ9;Q9UPQ9-1;Q9UPQ9-2 ENST00000335727;ENST00000400140 3 0.82707 1.4715 NaN 1.1349 0.88454 NaN Bromodomain;PWWP;zf-MYND cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;DNA binding;ion binding;metal ion binding;nucleic acid binding;protein binding;transition metal ion binding;zinc ion binding negative regulation of transcription from RNA polymerase II promoter;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 2 2 2 4.6 4.6 4.6 69.016 0.0012757 9321700 4684300 4637500 5595 IPI:IPI00873394.1 Zinc finger MYND domain-containing protein 11;Adenovirus 5 E1A-binding protein;Protein BS69 ZMYND11;BS69 Q15326 ENST00000309776;ENST00000381584;ENST00000381591;ENST00000397959;ENST00000397962 1 0.52856 1.1703 0.95785 0.7127 0.75271 1.1295 Gelsolin;Sec23_BS;Sec23_helical;Sec23_trunk;zf-Sec23_Sec24 COPII vesicle coat;endoplasmic reticulum membrane;endoplasmic reticulum part;Golgi apparatus part;intracellular part;macromolecular complex;membrane;membrane coat;membrane part;organelle membrane;organelle part;protein complex;vesicle coat binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding cellular component organization;cellular process;ER to Golgi vesicle-mediated transport;establishment of protein localization;intracellular protein transport;membrane organization;protein transport;transport;vesicle-mediated transport 3 3 3 3.4 3.4 3.4 119.75 6.2347E-27 61877000 25910000 35967000 5596 IPI:IPI00873472.1;IPI:IPI00178798.4 Protein transport protein Sec24A;SEC24-related protein A SEC24A O95486-1;O95486;O95486-2 ENST00000322887;ENST00000398844 2 0.70291 1.4669 0.64642 0.93861 0.95916 0.88017 SAPS cell part;cytoplasm;intracellular part binding;protein binding 14 14 14 28.4 28.4 28.4 96.723 1.1822E-202 505690000 266410000 239290000 5597 IPI:IPI00873586.3 Serine/threonine-protein phosphatase 6 regulatory subunit 1;SAPS domain family member 1 SAPS1;KIAA1115;PP6R1 Q9UPN7 ENST00000327021 1 0.72907 1.3488 0.88283 0.94466 0.92908 1.1309 Thioredoxin cell part;integral to membrane;intrinsic to membrane;membrane part biological regulation;cell redox homeostasis;cellular homeostasis;cellular process;homeostatic process;regulation of biological process;regulation of biological quality;regulation of cellular process 5 5 5 18.2 18.2 18.2 34.037 1.1524E-17 136750000 70650000 66096000 5598 IPI:IPI00873607.2;IPI:IPI00556619.1 Thioredoxin-related transmembrane protein 2;Thioredoxin domain-containing protein 14;Proliferation-inducing gene 26 protein TMX2;TXNDC14;CGI-31;My009;PIG26;PSEC0045;UNQ237/PRO270 Q9Y320-1;Q9Y320;Q9Y320-2 ENST00000278422;ENST00000319399;ENST00000378312 2 0.61789 1.8608 NaN 0.84051 1.2054 NaN SEA cell part;integral to membrane;intrinsic to membrane;membrane part binding;carbohydrate binding;glycosaminoglycan binding;heparin binding;molecular transducer activity;pattern binding;polysaccharide binding;receptor activity;signal transducer activity 2 2 2 2 2 2 138.59 0.0028824 3358200 1961900 1396300 5599 IPI:IPI00873766.1 Interphotoreceptor matrix proteoglycan 2;Sialoprotein associated with cones and rods proteoglycan;Interphotoreceptor matrix proteoglycan of 200 kDa IMPG2;IPM200 Q9BZV3 ENST00000394112 1 0.77335 1.6794 0.8535 1.0567 1.0487 1.1527 FKBP_C cell part;cytoplasmic part;cytosol;endoplasmic reticulum part;intracellular organelle part;intracellular part;organelle part;organelle subcompartment;terminal cisterna binding;catalytic activity;cytokine receptor binding;drug binding;FK506 binding;macrolide binding;peptidyl-prolyl cis-trans isomerase activity;protein binding;receptor binding;signal transducer activity;transforming growth factor beta receptor binding catabolic process;cell activation;'de novo' protein folding;glycoprotein catabolic process;immune system process;metabolic process;protein complex assembly;protein folding;regulation of immune system process;SMAD protein complex assembly 8 8 8 50.9 50.9 50.9 11.951 2.9805E-293 1429500000 731400000 698080000 5600 IPI:IPI00873810.1 Peptidyl-prolyl cis-trans isomerase FKBP1A;FK506-binding protein 1A;Rotamase;Immunophilin FKBP12 FKBP1A;FKBP1;FKBP12 P62942 ENST00000381719;ENST00000381742;ENST00000400137 K09568 1 0.79372 1.9764 1 1.1001 1.2624 1.2305 cell part;cytoplasmic part;early endosome;endosome;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle 11 11 11 15.3 15.3 15.3 95.988 1.2885E-165 106410000 55840000 50572000 5601 IPI:IPI00873904.1;IPI:IPI00607628.3;IPI:IPI00414215.1;IPI:IPI00423384.1 GRIP1-associated protein 1 GRIPAP1;KIAA1167 Q4V328-1;Q4V328;Q4V328-4;Q4V328-2 ENST00000015926;ENST00000357386;ENST00000376441;ENST00000376444 4 0.85529 2.0024 0.8926 1.1239 1.2586 1.2111 Pterin_4a 4-alpha-hydroxytetrahydrobiopterin dehydratase activity;binding;carbon-oxygen lyase activity;catalytic activity;hydro-lyase activity;lyase activity;protein binding biosynthetic process;cellular aromatic compound metabolic process;metabolic process;nitrogen compound metabolic process;regulation of biosynthetic process;regulation of transcription, DNA-dependent;tetrahydrobiopterin biosynthetic process 3 3 3 26.2 26.2 26.2 14.365 8.8294E-07 30626000 15875000 14751000 5602 IPI:IPI00874020.2 Pterin-4-alpha-carbinolamine dehydratase 2;4-alpha-hydroxy-tetrahydropterin dehydratase 2;DcoH-like protein DCoHm;Dimerization cofactor of hepatocyte nuclear factor 1 from muscle;HNF-1-alpha dimerization cofactor PCBD2;DCOH2;DCOHM Q9H0N5 ENST00000254908;ENST00000398833 K01724 1 0.59035 0.92258 NaN 0.75531 0.64411 NaN cell part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;nuclear membrane;nuclear part;organelle membrane;organelle part 8 8 8 4.7 4.7 4.7 244.29 7.4326E-31 13453000 7039400 6413500 5603 IPI:IPI00876931.1 Integrator complex subunit 1 INTS1;KIAA1440;UNQ1821/PRO3434 Q8N201 ENST00000389470;ENST00000404767;ENST00000407754 1 0.66162 1.1817 0.63537 0.87949 0.73519 0.80182 Drf_FH3;Drf_GBD;FH2;WH2 cell part;cytoplasmic part;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle actin binding;binding;cytoskeletal protein binding;enzyme binding;GTPase binding;protein binding;Ras GTPase binding;Rho GTPase binding;small GTPase binding actin cytoskeleton organization;actin filament-based process;cellular component organization;cellular process;cytoskeleton organization;organelle organization 7 7 7 8.3 8.3 8.3 135.62 1.5802E-63 15158000 8835400 6323000 5604 IPI:IPI00878985.1;IPI:IPI00876962.2;IPI:IPI00937711.1 Inverted formin-2;HBEBP2-binding protein C INF2;C14orf151;C14orf173 Q27J81-1;Q27J81;Q27J81-2 ENST00000252520;ENST00000392634 3 0.82696 1.6557 0.75144 1.0648 1.1325 1.0327 Ank;BTB cell part;integral to membrane;intrinsic to membrane;membrane part binding;DNA binding;nucleic acid binding;protein binding 6 6 6 8.3 8.3 8.3 120.88 9.9398E-127 7011400 3738500 3273000 5606 IPI:IPI00878014.3;IPI:IPI00889522.2;IPI:IPI00604727.4;IPI:IPI00181388.3 Ankyrin repeat and BTB/POZ domain-containing protein BTBD11 BTBD11 A6QL63-1;A6QL63;A6QL63-3;A6QL63-2 ENST00000280758;ENST00000341886;ENST00000357167 4 0.83493 1.6184 0.87184 1.054 1.0586 1.0794 SelT cell part;cytoplasm;intracellular part binding;selenium binding biological regulation;cell redox homeostasis;cellular homeostasis;cellular process;homeostatic process;regulation of biological process;regulation of biological quality;regulation of cellular process 4 4 4 44.3 44.3 44.3 12.403 3.3253E-26 228790000 120740000 108050000 5607 IPI:IPI00878073.1 Uncharacterized protein C17orf37;Protein C35;HBV X-transactivated gene 4 protein C17orf37;XTP4 Q9BRT3 ENST00000394231 K07401 1 0.62174 1.4828 0.73512 0.7438 1.0248 0.96766 TBC cell part;intracellular enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity;Rab GTPase activator activity;Ras GTPase activator activity;small GTPase regulator activity biological regulation;regulation of catalytic activity;regulation of GTPase activity;regulation of hydrolase activity;regulation of molecular function;regulation of Rab GTPase activity;regulation of Ras GTPase activity 4 4 4 9.7 9.7 9.7 87.198 7.2225E-36 3071600 1684200 1387400 5608 IPI:IPI00878181.2;IPI:IPI00465071.4 TBC1 domain family member 10B TBC1D10B;FP2461 Q4KMP7-2;Q4KMP7;Q4KMP7-1 ENST00000305663;ENST00000409939 2 0.48172 0.96839 0.4257 0.64877 0.62409 0.60448 AT_hook cell part;cytoplasm;intracellular organelle part;intracellular part;nuclear matrix;nuclear part;organelle part binding;DNA binding;nucleic acid binding biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;multicellular organismal development;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription 18 18 18 8.9 8.9 8.9 256.25 5.3397E-83 106930000 63057000 43869000 5609 IPI:IPI00878213.1;IPI:IPI00954159.1 AT-hook-containing transcription factor 1;Embryonic large molecule derived from yolk sac AHCTF1;ELYS;TMBS62;MSTP108 Q8WYP5-2;Q8WYP5;Q8WYP5-1 ENST00000326225;ENST00000361182 2 0.76311 1.8467 0.7228 1.1204 1.1524 1.0516 Thioredoxin intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part catalytic activity;disulfide oxidoreductase activity;electron carrier activity;oxidoreductase activity;oxidoreductase activity, acting on sulfur group of donors;protein disulfide oxidoreductase activity cellular homeostasis;cellular metabolic process;cellular process;electron transport chain;generation of precursor metabolites and energy;glycerol ether metabolic process;homeostatic process;metabolic process;organic ether metabolic process;transport 2 2 2 21.7 21.7 21.7 18.383 7.7123E-18 46355000 26344000 20011000 5610 IPI:IPI00878215.1 Thioredoxin, mitochondrial;Thioredoxin-2 TXN2;TRX2 Q99757 ENST00000216185;ENST00000403313 1 0.88462 1.7046 0.83997 1.0697 1.0623 1.101 5 5 2 0.8 0.8 0.3 780.6 0.001402 415460000 219610000 195850000 5611 IPI:IPI00878236.2 Fibrous sheath-interacting protein 2 FSIP2 Q5CZC0-1;Q5CZC0 ENST00000326147;ENST00000344648;ENST00000397005 1 0.43523 1.0163 0.31535 0.55404 0.65807 0.4501 WD40 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex;transcription factor TFIIIC complex binding;protein binding biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;transcription;transcription from RNA polymerase III promoter;transcription, DNA-dependent 6 6 6 8.8 8.8 8.8 100.68 2.1597E-47 49067000 28229000 20838000 5612 IPI:IPI00878252.1;IPI:IPI00412837.3 General transcription factor 3C polypeptide 2;Transcription factor IIIC subunit beta;TF3C-beta;TFIIIC 110 kDa subunit GTF3C2;KIAA0011 Q8WUA4-1;Q8WUA4;Q8WUA4-2 ENST00000264720;ENST00000359541 2 1.1059 2.1428 0.77293 1.4051 1.4093 1.0414 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 8 8 8 13 13 13 78.429 3.4032E-52 27556000 14803000 12754000 5613 IPI:IPI00878754.1;IPI:IPI00789246.1 Pre-mRNA-processing factor 39;PRP39 homolog PRPF39 Q86UA1-1;Q86UA1;Q86UA1-2 ENST00000355765;ENST00000355846 2 0.6316 1.0996 0.70146 0.7717 0.78575 0.86305 CHCH 5 5 5 52.1 52.1 52.1 11.308 2.0086E-39 163740000 89047000 74692000 5614 IPI:IPI00009817.5;IPI:IPI00878815.1 Coiled-coil-helix-coiled-coil-helix domain-containing protein 8;E2-induced gene 2 protein CHCHD8;E2IG2 Q9NYJ1-2;Q9NYJ1;Q9NYJ1-1 ENST00000355693 2 0.49226 0.84556 0.45007 0.64004 0.58596 0.56638 cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;RNA binding 4 4 4 20.7 20.7 20.7 32.334 3.1712E-32 53384000 29192000 24192000 5616 IPI:IPI00879006.1 Ribosomal RNA-processing protein 7 homolog A;Gastric cancer antigen Zg14 RRP7A;CGI-96 Q9Y3A4 ENST00000323013 1 0.75951 1.7391 0.72656 1.0077 1.1591 0.97464 C1-set cell part;membrane;plasma membrane binding;molecular transducer activity;protein binding;receptor activity;signal transducer activity immune response;immune system process;response to stimulus 6 6 6 26.5 26.5 26.5 34.617 8.8448E-92 481380000 270010000 211370000 5617 IPI:IPI00879200.2;IPI:IPI00003986.1 T-cell receptor beta chain C region TRBC1 P01850 ENST00000390409 2 0.78426 2.1484 0.72902 1.0148 1.4358 0.99361 GAT;VHS centrosome;cytosol;early endosome;endosome;intracellular membrane-bounded organelle;intracellular organelle;membrane;membrane-bounded organelle;microtubule organizing center;non-membrane-bounded organelle;organelle binding;protein binding cellular component organization;cellular process;endocytosis;endosome transport;establishment of protein localization;intracellular protein transport;membrane invagination;membrane organization;protein transport;transport;vesicle-mediated transport 5 5 5 12.2 12.2 12.2 53.874 2.1608E-17 62037000 32952000 29085000 5618 IPI:IPI00941588.1;IPI:IPI00913835.1;IPI:IPI00879680.2;IPI:IPI00913911.1 Target of Myb protein 1 TOM1 O60784-2;O60784;O60784-1;O60784-4 ENST00000337040 4 0.78067 1.6822 0.86525 1.06 1.1045 1.1348 Filament;IF_tail structural molecule activity 32 29 29 42.3 38.5 38.5 67.688 0 1352300000 707820000 644500000 5619 IPI:IPI00879819.1 Lamin-B2 LMNB2;LMN2 Q03252 ENST00000325327 K07611 1 0.73993 1.3119 0.66186 0.92175 0.89744 0.84894 DBP10CT;DEAD;Helicase_C cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part ATP-dependent RNA helicase activity;catalytic activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;RNA binding;RNA helicase activity;transcription cofactor activity;transcription corepressor activity cell communication;intracellular signaling cascade;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;RNA processing;signal transduction;transcription Folate biosynthesis 13 13 13 18.7 18.7 18.7 98.594 1.4577E-110 267650000 141970000 125680000 5620 IPI:IPI00879999.1 ATP-dependent RNA helicase DDX54;DEAD box protein 54;ATP-dependent RNA helicase DP97;DEAD box RNA helicase 97 kDa DDX54 Q8TDD1 ENST00000306014 K01529 1 0.81602 1.3502 NaN 1.0275 0.86824 NaN OB_RNB;RNB binding;catalytic activity;exonuclease activity;hydrolase activity;hydrolase activity, acting on ester bonds;nuclease activity;nucleic acid binding;ribonuclease activity;RNA binding 5 5 5 6.9 6.9 6.9 99.209 1.1424E-11 9716700 6071800 3644900 5621 IPI:IPI00880048.1;IPI:IPI00217752.3;IPI:IPI00167753.1;IPI:IPI00465384.3;IPI:IPI00385160.2 DIS3-like exonuclease 2 DIS3L2;FAM6A Q8IYB7-1;Q8IYB7;Q8IYB7-2;Q8IYB7-3 ENST00000273009;ENST00000325385;ENST00000360410;ENST00000390005;ENST00000409307 5 0.84344 1.633 0.94007 1.0438 1.1232 1.1651 Lamp cell fraction;endosome membrane;insoluble fraction;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;lysosomal membrane;membrane;membrane fraction;organelle membrane;organelle part;vacuolar membrane 4 4 4 9.8 9.8 9.8 44.882 4.1715E-144 284270000 145130000 139140000 5622 IPI:IPI00884105.2 Lysosome-associated membrane glycoprotein 1;CD107 antigen-like family member A LAMP1 P11279 ENST00000332556 K06528 1 0.72534 1.6853 0.69646 0.91964 1.1089 0.90959 11 11 4 8.6 8.6 3.1 164.81 5.1335E-55 65697000 33757000 31940000 5623 IPI:IPI00885054.1;IPI:IPI00884966.1;IPI:IPI00398837.3;IPI:IPI00395716.7 Coiled-coil domain-containing protein 88B;Brain leucine zipper domain-containing protein;Hook-related protein 3 CCDC88B;BRLZ A6NC98-1;A6NC98;A6NC98-4;A6NC98-2 ENST00000356786;ENST00000394494 4 1.3535 1.7608 0.79503 1.8947 1.1119 1.0531 PWWP binding;protein binding 5 4 4 10.3 9.1 9.1 74.316 3.3289E-146 97754000 54132000 43622000 5624 IPI:IPI00939776.1;IPI:IPI00885081.1 Hepatoma-derived growth factor-related protein 2 HDGFRP2;HDGF2;UNQ785/PRO1604 Q7Z4V5-1;Q7Z4V5;Q7Z4V5-2 ENST00000301284 2 1.0941 1.4607 0.91084 1.5006 0.86348 1.2984 cell part;cytoplasm;cytoskeletal part;intracellular organelle part;intracellular part;microtubule;organelle part 4 4 4 14.9 14.9 14.9 44.857 1.5937E-56 465790000 231870000 233920000 5625 IPI:IPI00305490.5;IPI:IPI00885183.1 HAUS augmin-like complex subunit 8;HEC1/NDC80-interacting centrosome-associated protein 1;Sarcoma antigen NY-SAR-48 HAUS8;HICE1 Q9BT25-1;Q9BT25;Q9BT25-2 ENST00000253669 2 NaN NaN 0.72397 NaN NaN 0.96897 LRR_1 binding;protein binding biological regulation;cell communication;cellular process;regulation of biological process;regulation of cellular process;signal transduction 2 2 2 2.9 2.9 2.9 98.034 0.0040566 73214 50652 22563 5626 IPI:IPI00887636.1 Leucine-rich repeat and death domain-containing protein LOC401387 A4D1F6-1;A4D1F6 ENST00000343318 1 0.76093 1.3683 0.76805 0.94739 0.93293 0.99246 DEAD;Helicase_C cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;ATP-dependent helicase activity;binding;catalytic activity;helicase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;RNA binding;RNA helicase activity;RNA-dependent ATPase activity cellular biopolymer metabolic process;cellular process;macromolecule metabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing 46 46 36 52.5 52.5 44 80.272 0 8626000000 4415000000 4211000000 5628 IPI:IPI00889541.2;IPI:IPI00651653.1;IPI:IPI00651677.1;IPI:IPI00952778.1 Probable ATP-dependent RNA helicase DDX17;DEAD box protein 17;RNA-dependent helicase p72;DEAD box protein p72 DDX17 Q92841-4;Q92841;Q92841-3;Q92841-2;Q92841-1 ENST00000216019;ENST00000381633;ENST00000396821;ENST00000403230 4 1.1468 2.1674 0.97412 1.5926 1.317 1.4067 C2;efhand;PH;RhoGEF;SH3_1;SH3_2 cell part;cytoplasm;intracellular part binding;calcium ion binding;guanyl-nucleotide exchange factor activity;Ras guanyl-nucleotide exchange factor activity;Rho guanyl-nucleotide exchange factor activity;SH3/SH2 adaptor activity;signal transducer activity;small GTPase regulator activity cellular component organization;cellular process;endocytosis;membrane invagination;membrane organization;regulation of cell communication;regulation of Rho protein signal transduction;regulation of signal transduction;transport;vesicle-mediated transport 5 5 5 4.4 4.4 4.4 193.33 1.4801E-22 11082000 5666100 5415900 5631 IPI:IPI00937782.1;IPI:IPI00941398.1;IPI:IPI00943185.1;IPI:IPI00892957.2 Intersectin-2;SH3 domain-containing protein 1B;SH3P18;SH3P18-like WASP-associated protein ITSN2;KIAA1256;SH3D1B;SWAP Q9NZM3-1;Q9NZM3;Q9NZM3-2;Q9NZM3-4;Q9NZM3-3 ENST00000355123;ENST00000380868;ENST00000380883 4 0.78293 1.9571 0.85889 1.0368 1.2784 1.1015 Fer2 cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part 2 iron, 2 sulfur cluster binding;binding;cation binding;electron carrier activity;ion binding;iron ion binding;iron-sulfur cluster binding;metal cluster binding;metal ion binding;transition metal ion binding cellular metabolic process;cellular process;electron transport chain;establishment of localization;generation of precursor metabolites and energy;metabolic process;oxidation reduction;transport 2 2 2 12.6 12.6 12.6 19.521 4.7548E-05 25159000 13569000 11590000 5632 IPI:IPI00894257.5 Adrenodoxin-like protein, mitochondrial;Ferredoxin-1-like protein FDX1L Q6P4F2 ENST00000393708 1 0.60134 1.3779 3.6252 0.8785 0.87447 4.4615 4 4 4 43.1 43.1 43.1 13.775 1.2988E-166 44599000 21526000 23073000 5634 IPI:IPI00895892.1 Proteasome assembly chaperone 4 PSMG4;C6orf86;PAC4 Q5JS54 ENST00000380303 K11878 1 0.80754 1.712 0.91018 1.101 1.0945 1.2176 TPD52 cell part;cytoplasmic part;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle;perinuclear region of cytoplasm binding;calcium ion binding;cation binding;identical protein binding;ion binding;metal ion binding;protein binding;protein dimerization activity;protein heterodimerization activity;protein homodimerization activity anatomical structure morphogenesis;B cell activation;B cell differentiation;cell activation;cell differentiation;cellular process;developmental process;immune system process;leukocyte differentiation;lymphocyte differentiation;transport 10 10 10 45.6 45.6 45.6 26.382 8.2031E-237 2204300000 1136400000 1067900000 5635 IPI:IPI00873344.1;IPI:IPI00896474.2;IPI:IPI00619958.3 Tumor protein D52;Protein N8 TPD52 P55327-3;P55327;P55327-2;P55327-1 ENST00000379097 3 1.2482 2.253 1.1849 1.7839 1.4816 1.5617 CH;PH;RhoGEF;SH3_1 cell part;cytoplasmic part;cytosol;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part enzyme regulator activity;GTPase regulator activity;guanyl-nucleotide exchange factor activity;Ras guanyl-nucleotide exchange factor activity;Rho guanyl-nucleotide exchange factor activity;small GTPase regulator activity cell communication;cellular process;intracellular signaling cascade;regulation of cell communication;regulation of Ras protein signal transduction;regulation of Rho protein signal transduction;regulation of signal transduction;signal transduction 9 4 4 15.6 9.2 9.2 82.57 6.932E-128 49078000 23726000 25352000 5636 IPI:IPI00900260.1;IPI:IPI00945115.1;IPI:IPI00449909.1;IPI:IPI00449908.6;IPI:IPI00449907.1;IPI:IPI00900378.1 Rho guanine nucleotide exchange factor 7;PAK-interacting exchange factor beta;Beta-Pix;COOL-1;p85 ARHGEF7;COOL1;KIAA0142;P85SPR;PAK3BP;PIXB;Nbla10314 Q14155-5;Q14155;Q14155-1;Q14155-4;Q14155-3;Q14155-2;Q14155-6 ENST00000317133;ENST00000375739;ENST00000375741 6 6.9848 0.17441 0.34753 9.1917 0.11506 0.47783 DUF2428 binding 2 2 2 1.4 1.4 1.4 219.6 2.4748E-08 26061000 4303100 21757000 5637 IPI:IPI00936978.1;IPI:IPI00900266.2;IPI:IPI00900350.1;IPI:IPI00917435.1 Thyroid adenoma-associated protein;Gene inducing thyroid adenomas protein THADA;GITA;KIAA1767 Q6YHU6-1;Q6YHU6;Q6YHU6-2;Q6YHU6-3;Q6YHU6-4 ENST00000330266;ENST00000405006;ENST00000405975 4 0.89276 1.7597 0.75156 1.1543 1.1563 1.0006 AAA_5 extracellular region ATP binding;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity 22 22 22 12.9 12.9 12.9 214.82 9.9907E-91 163520000 88035000 75485000 5639 IPI:IPI00900366.1;IPI:IPI00946725.1;IPI:IPI00376322.2 Uncharacterized protein KIAA0564 KIAA0564 A3KMH1-1;A3KMH1;A3KMH1-3;A3KMH1-2 ENST00000281496;ENST00000379310 3 0.49226 1.0468 0.61113 0.64994 0.67885 0.81011 eIF2A cell part;cytoplasmic part;eukaryotic translation initiation factor 2 complex;intracellular part;macromolecular complex;protein complex binding;nucleic acid binding;ribonucleoprotein binding;ribosome binding;RNA binding;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity;tRNA binding biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of translation;translation 21 21 21 45.5 45.5 45.5 64.989 2.3484E-285 732410000 410690000 321720000 5640 IPI:IPI00902564.1;IPI:IPI00939283.2 Eukaryotic translation initiation factor 2A;65 kDa eukaryotic translation initiation factor 2A EIF2A;CDA02;MSTP004;MSTP089 Q9BY44-1;Q9BY44;Q9BY44-2 ENST00000273435;ENST00000383043;ENST00000406576 2 0.80561 1.516 0.72521 1.0305 0.98634 0.97488 UBA;UCH catalytic activity;cysteine-type peptidase activity;hydrolase activity;hydrolase activity, acting on ester bonds;peptidase activity;peptidase activity, acting on L-amino acid peptides;thiolester hydrolase activity;ubiquitin thiolesterase activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process 26 26 26 11.6 11.6 11.6 294.36 1.889E-189 224790000 122040000 102750000 5641 IPI:IPI00902614.2 Ubiquitin carboxyl-terminal hydrolase 24;Ubiquitin thioesterase 24;Ubiquitin-specific-processing protease 24;Deubiquitinating enzyme 24 USP24;KIAA1057 Q9UPU5 ENST00000294383 K11840 1 0.78927 1.7645 0.84059 1.105 1.0574 1.2191 ERM;FERM_C;FERM_M;FERM_N cell part;cytoplasm;cytoskeleton;extrinsic to membrane;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane part;non-membrane-bounded organelle;organelle;plasma membrane actin binding;binding;cytoskeletal protein binding;protein binding negative regulation of macromolecule metabolic process;negative regulation of metabolic process;regulation of actin polymerization or depolymerization;sensory perception;sensory perception of sound;system process Regulation of actin cytoskeleton 20 6 6 30.4 12.3 12.3 68.563 3.6438E-191 82679000 44409000 38271000 5642 IPI:IPI00903145.1 Radixin RDX P35241 ENST00000343115;ENST00000405097 K05762 1 0.64765 1.0527 0.66056 0.79801 0.74473 0.8284 cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;Golgi apparatus part;Golgi membrane;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part;trans-Golgi network binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;lipase activity;magnesium ion binding;phospholipase activity;phosphoric diester hydrolase activity;protein binding;sphingomyelin phosphodiesterase activity catabolic process;lipid metabolic process;membrane lipid metabolic process;metabolic process;phospholipid catabolic process;phospholipid metabolic process;sphingolipid metabolic process;sphingomyelin catabolic process;sphingomyelin metabolic process Sphingolipid metabolism 10 10 10 14.3 14.3 14.3 98.147 6.7637E-48 185010000 98827000 86186000 5643 IPI:IPI00828125.1;IPI:IPI00793691.3;IPI:IPI00903175.1;IPI:IPI00827746.1;IPI:IPI00828176.1 Sphingomyelin phosphodiesterase 4;Neutral sphingomyelinase 3;Neutral sphingomyelinase III SMPD4;KIAA1418 Q9NXE4-4;Q9NXE4;Q9NXE4-1;Q9NXE4-2;Q9NXE4-3;Q9NXE4-5 ENST00000339679;ENST00000351288;ENST00000392978;ENST00000409031 K12353 5 0.71245 1.7372 0.62889 0.98217 1.0806 0.86125 ELM2;Myb_DNA-binding cell part;cytoplasm;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part binding;DNA binding;nucleic acid binding;protein binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 6 3 3 12.1 6.5 6.5 55.581 1.0441E-09 23354000 12855000 10499000 5644 IPI:IPI00903300.3;IPI:IPI00164550.7 REST corepressor 3 RCOR3;KIAA1343 Q9P2K3-1;Q9P2K3;Q9P2K3-2 ENST00000367005;ENST00000367006 2 0.74351 1.3374 0.82222 0.95795 0.9075 1.039 Tubulin;Tubulin_C cell part;cytoskeletal part;intracellular organelle part;intracellular part;microtubule;organelle part binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleotide binding;protein binding;pyrophosphatase activity;receptor binding cell killing;cell motion;immune effector process;immune system process;induction of apoptosis;leukocyte mediated cytotoxicity;leukocyte mediated immunity;lymphocyte mediated immunity;natural killer cell mediated immunity;protein complex assembly Gap junction 28 8 7 60.3 20.9 17.7 52.048 0 22101000000 11337000000 10763000000 5645 IPI:IPI00909140.5 Tubulin beta chain;Tubulin beta-5 chain TUBB;TUBB5;OK/SW-cl.56 P07437 ENST00000259925;ENST00000327892;ENST00000383564 K07375 1 0.87766 1.4694 0.91681 1.1528 0.95778 1.1767 MAGE binding;protein binding 12 12 12 26.1 26.1 26.1 37.833 1.833E-120 630960000 313380000 317570000 5646 IPI:IPI00910524.1;IPI:IPI00157174.1;IPI:IPI00301104.1;IPI:IPI00301082.1;IPI:IPI00299085.3;IPI:IPI00046955.9;IPI:IPI00289940.2;IPI:IPI00065350.1;IPI:IPI00738845.3;IPI:IPI00018074.1 Melanoma-associated antigen 4;MAGE-4 antigen;MAGE-X2 antigen;MAGE-41 antigen;Cancer/testis antigen 1.4 MAGEA4;MAGE4 P43358 ENST00000276344;ENST00000360243;ENST00000370335;ENST00000370340;ENST00000393920;ENST00000393921 10 0.87415 1.5994 0.83091 1.1357 1.0491 1.0263 Ank;BTB;FYVE cell part;cytoplasmic part;endosomal part;endosome membrane;intracellular organelle part;intracellular part;membrane;organelle membrane;organelle part binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding 12 12 12 14 14 14 128.48 3.8859E-54 160890000 86442000 74447000 5647 IPI:IPI00914539.1;IPI:IPI00159899.9 Ankyrin repeat and FYVE domain-containing protein 1;Ankyrin repeats hooked to a zinc finger motif ANKFY1;ANKHZN;KIAA1255 Q9P2R3-2;Q9P2R3;Q9P2R3-1 ENST00000341657 2 0.78915 1.3367 0.74433 0.98926 0.90407 1.0103 polyprenyl_synt cell part;cytoplasm;intracellular part catalytic activity;dimethylallyltranstransferase activity;geranyltranstransferase activity;prenyltransferase activity;transferase activity;transferase activity, transferring alkyl or aryl (other than methyl) groups alcohol metabolic process;cholesterol biosynthetic process;cholesterol metabolic process;isoprenoid biosynthetic process;isoprenoid metabolic process;lipid metabolic process;metabolic process;steroid biosynthetic process;steroid metabolic process Biosynthesis of steroids;Terpenoid biosynthesis 9 9 9 25.5 25.5 25.5 48.275 9.6942E-141 2618800000 1397300000 1221400000 5648 IPI:IPI00914566.2 Farnesyl pyrophosphate synthetase;Farnesyl diphosphate synthetase;Dimethylallyltranstransferase;Geranyltranstransferase FDPS;FPS;KIAA1293 P14324 ENST00000356657;ENST00000368356 K00787;K00795 1 0.60598 1.1433 0.69335 0.78647 0.80127 0.8684 tRNA_SAD cell part;cytoplasm;intracellular part alanine-tRNA ligase activity;aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;ligase activity;ligase activity, forming carbon-oxygen bonds;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding alanyl-tRNA aminoacylation;cellular amino acid and derivative metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;tRNA aminoacylation for protein translation;tRNA metabolic process 5 5 5 14.3 14.3 14.3 58.752 1.1215E-15 94860000 52813000 42047000 5649 IPI:IPI00914584.1;IPI:IPI00916940.1 Alanyl-tRNA synthetase domain-containing protein 1 AARSD1 Q9BTE6-2;Q9BTE6;Q9BTE6-1 ENST00000360221;ENST00000409103;ENST00000409399 2 0.74128 1.5513 0.67386 0.98407 0.98315 1.0401 Adaptin_N;Alpha_adaptin_C;Alpha_adaptinC2 AP-2 adaptor complex;AP-type membrane coat adaptor complex;clathrin adaptor complex;cytoplasmic part;cytoplasmic vesicle part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;membrane part;organelle part;protein complex binding;lipid binding;protein transporter activity;substrate-specific transporter activity;transporter activity cellular process;endocytosis;intracellular protein transport;membrane invagination;protein transport;regulation of immune effector process;regulation of immune system process;regulation of response to biotic stimulus;transport Huntington's disease 26 18 18 34.6 23.4 23.4 103.96 0 604950000 338260000 266700000 5650 IPI:IPI00914938.1;IPI:IPI00016621.7;IPI:IPI00914952.1 AP-2 complex subunit alpha-2;Adapter-related protein complex 2 alpha-2 subunit;Adaptor protein complex AP-2 subunit alpha-2;Alpha2-adaptin;Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit;Alpha-adaptin C;Clathrin assembly protein complex 2 alpha-C large chain;100 kDa coated vesicle protein C;Huntingtin-interacting protein J;Huntingtin yeast partner J AP2A2;ADTAB;CLAPA2;HYPJ;KIAA0899 O94973-1;O94973;O94973-2;O94973-3 ENST00000332231 K11824 3 0.6346 1.3133 0.6701 0.86208 0.86336 0.86694 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;nucleic acid binding;protein binding;RNA binding cellular process;metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA processing;RNA splicing;transport 27 27 27 21.2 21.2 21.2 182.77 0 622700000 332940000 289760000 5651 IPI:IPI00915022.2;IPI:IPI00158615.8 THO complex subunit 2 THOC2;CXorf3 Q8NI27-1;Q8NI27;Q8NI27-2 ENST00000355725;ENST00000408933 2 6.5223 1.2532 0.87096 10.119 0.79962 1.25 3_5_exonuc cell part;cytoplasmic part;cytoskeleton;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;non-membrane-bounded organelle;organelle 3'-5' exonuclease activity;binding;catalytic activity;exonuclease activity;hydrolase activity;hydrolase activity, acting on ester bonds;nuclease activity;nucleic acid binding cellular metabolic process;cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;primary metabolic process 3 3 3 8.1 8.1 8.1 56.345 1.3966E-26 13223000 3880300 9342300 5652 IPI:IPI00915852.1 Exonuclease 3'-5' domain-containing protein 2;Exonuclease 3'-5' domain-like-containing protein 2 EXD2;C14orf114;EXDL2 Q9NVH0 ENST00000193422;ENST00000409014;ENST00000409018;ENST00000409242;ENST00000409675;ENST00000409949 1 0.8545 1.6372 0.89292 1.0945 1.0681 1.1146 Ldh_1_C;Ldh_1_N cell part;cytoplasmic part;cytosol;intracellular part catalytic activity;malate dehydrogenase activity;malic enzyme activity;oxidoreductase activity;oxidoreductase activity, acting on CH-OH group of donors;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor acetyl-CoA metabolic process;alcohol metabolic process;carbohydrate metabolic process;generation of precursor metabolites and energy;glucose catabolic process;glucose metabolic process;monosaccharide metabolic process;organic acid metabolic process Carbon fixation in photosynthetic organisms;Citrate cycle (TCA cycle);Glyoxylate and dicarboxylate metabolism;Pyruvate metabolism;Reductive carboxylate cycle (CO2 fixation) 14 14 14 42.6 42.6 42.6 38.655 0 2453500000 1300500000 1153100000 5653 IPI:IPI00916111.2 Malate dehydrogenase, cytoplasmic;Cytosolic malate dehydrogenase MDH1;MDHA P40925 ENST00000233114;ENST00000394423 K00026 1 1.0847 1.5178 0.82199 1.4766 1.0063 1.0993 Sec15 cell cortex part;cell part;cytoplasmic part;exocyst;intracellular part;macromolecular complex;protein complex cellular process;establishment of localization;establishment of protein localization;membrane docking;protein transport;transport;vesicle docking;vesicle docking during exocytosis 4 4 4 8.4 8.4 8.4 79.368 7.4785E-27 18209000 8709300 9500200 5654 IPI:IPI00917263.1 Exocyst complex component 6B;Exocyst complex component Sec15B;SEC15-like protein 2 EXOC6B;KIAA0919;SEC15B;SEC15L2 Q9Y2D4 ENST00000290144;ENST00000410112 1 0.77256 1.1668 0.77527 0.97242 0.76739 0.98252 4 4 3 15.5 15.5 12.8 36.056 3.3723E-14 33905000 17957000 15948000 5655 IPI:IPI00921468.1;IPI:IPI00921125.2 GATS-like protein 2;GATS-like protein 1 GATSL2;GATSL1 A6NHX0;A6NNH0 ENST00000361825;ENST00000332301 2 0.71323 1.9307 0.6013 0.90101 1.382 0.73918 Clat_adaptor_s AP-type membrane coat adaptor complex;clathrin adaptor complex;clathrin coat;clathrin coat of trans-Golgi network vesicle;clathrin vesicle coat;coated pit;cytosol;macromolecular complex;membrane coat;organelle part;protein complex;vesicle coat binding;protein binding;protein transporter activity;substrate-specific transporter activity;transporter activity cellular component organization;cellular process;endocytosis;establishment of protein localization;intracellular protein transport;intracellular transport;membrane invagination;membrane organization;protein transport;transport;vesicle-mediated transport 3 1 1 15.3 5.7 5.7 18.615 1.2425E-07 13585000 7640900 5944600 5656 IPI:IPI00922006.2 AP-1 complex subunit sigma-2;Adapter-related protein complex 1 sigma-1B subunit;Adaptor protein complex AP-1 sigma-1B subunit;Sigma-adaptin 1B;Sigma1B-adaptin;Golgi adaptor HA1/AP1 adaptin sigma-1B subunit;Clathrin assembly protein complex 1 sigma-1B small chain;Sigma 1B subunit of AP-1 clathrin AP1S2;DC22 P56377 ENST00000329235;ENST00000380291 K12394 1 0.76794 1.5681 0.77008 0.97744 1.0149 0.93579 E1_dh cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part binding;catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor;protein binding;pyruvate dehydrogenase (acetyl-transferring) activity;pyruvate dehydrogenase activity alcohol metabolic process;carbohydrate metabolic process;catabolic process;cellular process;generation of precursor metabolites and energy;glucose catabolic process;glucose metabolic process;glycolysis;metabolic process;monosaccharide metabolic process Butanoate metabolism;Citrate cycle (TCA cycle);Glycolysis / Gluconeogenesis;Pyruvate metabolism;Valine, leucine and isoleucine biosynthesis 16 16 16 33.5 33.5 33.5 44.108 4.1296E-131 405690000 220510000 185180000 5658 IPI:IPI00922697.1;IPI:IPI00024087.3 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial;PDHE1-A type I PDHA1;PHE1A P08559 ENST00000355808 K00161 2 0.94612 1.443 0.81331 1.2235 0.96451 1.0238 2 2 2 17.2 17.2 17.2 10.741 4.1027E-06 92777000 49051000 43726000 5661 IPI:IPI00924667.1 UPF0539 protein C7orf59 C7orf59 Q0VGL1 ENST00000341942 1 0.72711 2.3905 0.75673 1.0085 1.5158 1.0933 Abhydrolase_3 cell fraction;endoplasmic reticulum;insoluble fraction;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intrinsic to membrane;membrane fraction;membrane-bounded organelle;microsome;organelle;vesicular fraction carboxylesterase activity;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds catabolic process;lipid catabolic process;lipid metabolic process;metabolic process;primary metabolic process 4 4 4 11.6 11.6 11.6 49.881 3.1555E-102 16835000 10086000 6748700 5662 IPI:IPI00924788.2;IPI:IPI00925612.1;IPI:IPI00790972.2 Arylacetamide deacetylase-like 1;Neutral cholesterol ester hydrolase AADACL1;KIAA1363 Q6PIU2-2;Q6PIU2;Q6PIU2-1;Q6PIU2-3 ENST00000273512 3 0.77192 2.0211 0.73614 1.0451 1.2558 1.0236 Ank cell part;cytoplasm;intracellular part binding;protein binding cell growth;cellular process;posttranscriptional regulation of gene expression;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of translation 7 7 7 75.4 75.4 75.4 12.895 4.9647E-211 583050000 318710000 264350000 5663 IPI:IPI00924816.1 Myotrophin;Protein V-1 MTPN P58546 ENST00000356707;ENST00000393085 1 1.0196 2.167 1.0904 1.432 1.297 1.4719 Armet extracellular region binding;growth factor activity;protein binding;receptor binding 9 9 9 47.5 47.5 47.5 20.256 2.0132E-203 1406100000 711090000 694980000 5664 IPI:IPI00924819.1 Protein ARMET;Mesencephalic astrocyte-derived neurotrophic factor;Arginine-rich protein ARMET;ARP P55145 ENST00000273628 1 0.74673 1.433 0.72974 0.99269 0.95415 0.92276 tRNA_synt_1c_R1;tRNA_synt_1c_R2;tRNA-synt_1c;tRNA-synt_1c_C cell part;cytoplasm;intracellular part aminoacyl-tRNA ligase activity;ATP binding;binding;catalytic activity;glutamine-tRNA ligase activity;ligase activity;ligase activity, forming carbon-oxygen bonds;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding glutaminyl-tRNA aminoacylation;glutamyl-tRNA aminoacylation;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organic acid metabolic process;tRNA aminoacylation for protein translation;tRNA metabolic process Aminoacyl-tRNA biosynthesis;Glutamate metabolism 45 45 45 63.6 63.6 63.6 87.798 0 2139000000 1111000000 1028000000 5665 IPI:IPI00925046.1 Glutaminyl-tRNA synthetase;Glutamine--tRNA ligase QARS P47897 ENST00000306125 K01886 1 0.81899 1.4765 0.79541 1.1231 0.9046 1.1405 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle 9 9 8 13.1 13.1 12.3 94.868 2.2822E-87 61375000 32036000 29339000 5666 IPI:IPI00925255.1;IPI:IPI00856118.3 Round spermatid basic protein 1-like protein RSBN1L Q6PCB5-1;Q6PCB5;Q6PCB5-2 ENST00000334955 2 0.87907 2.3464 NaN 1.1554 1.6702 NaN cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;ER-Golgi intermediate compartment membrane;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part 2 2 2 1.6 1.6 1.6 235.7 1.7117E-07 1906300 916040 990260 5667 IPI:IPI00925924.1 Protein FAM38A;Membrane protein induced by beta-amyloid treatment FAM38A;KIAA0233 Q92508 ENST00000301015 1 0.29472 0.48899 0.34113 0.38841 0.31918 0.45199 Cyt-b5;FA_desaturase cell fraction;endoplasmic reticulum membrane;insoluble fraction;integral to membrane;intracellular part;intrinsic to membrane;membrane;membrane fraction;membrane part;microsome;organelle membrane;organelle part;vesicular fraction binding;C-5 sterol desaturase activity;catalytic activity;iron ion binding;oxidoreductase activity;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;protein binding fatty acid biosynthetic process;fatty acid metabolic process;generation of precursor metabolites and energy;lipid metabolic process;organic acid metabolic process;phospholipid metabolic process;unsaturated fatty acid biosynthetic process Biosynthesis of unsaturated fatty acids 4 4 4 12.8 12.8 12.8 51.964 1.246E-12 20391000 11032000 9358600 5668 IPI:IPI00926423.2 Fatty acid desaturase 1;Delta(5) fatty acid desaturase FADS1;FADSD5 O60427 ENST00000350997 K10224 1 1.1576 2.0942 1.3009 1.5453 1.3903 1.6302 LIM adherens junction;cell junction;cell-cell adherens junction;cell-cell junction;cell-substrate adherens junction;cell-substrate junction;cytoplasm;focal adhesion;integral to membrane;integral to plasma membrane;intrinsic to membrane;nucleus;stress fiber binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding biological adhesion;cell adhesion;cell communication;cell-cell signaling;cellular process;interspecies interaction between organisms;multi-organism process;regulation of biological process;regulation of cellular process;signal transduction Focal adhesion 8 8 8 24.3 24.3 24.3 61.277 1.5149E-62 411990000 196750000 215240000 5669 IPI:IPI00926625.1 Zyxin;Zyxin-2 ZYX Q15942 ENST00000322764;ENST00000354434;ENST00000404957 K06273 1 0.39677 0.92462 0.38435 0.49795 0.6444 0.49203 IFRD;IFRD_C binding cell differentiation;cell proliferation;cellular developmental process;cellular process;developmental process 2 2 2 5.4 5.4 5.4 48.047 0.00063514 4493200 2545600 1947700 5670 IPI:IPI00926673.1 Interferon-related developmental regulator 2;SKMC15 protein IFRD2 Q12894 ENST00000336089 1 0.78988 1.9754 0.98997 1.0755 1.2054 1.2387 GSHPx cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle antioxidant activity;binding;catalytic activity;glutathione peroxidase activity;oxidoreductase activity;peroxidase activity;proteasome inhibitor activity;proteasome regulator activity;protein binding;selenium binding cellular amino acid and derivative metabolic process;circulatory system process;heart process;peptide metabolic process;release of cytochrome c from mitochondria;response to reactive oxygen species;system process Arachidonic acid metabolism;Glutathione metabolism 6 6 6 34.5 34.5 34.5 22.041 6.5622E-22 59787000 31100000 28687000 5671 IPI:IPI00927606.1 Glutathione peroxidase 1;GSHPx-1;Cellular glutathione peroxidase GPX1 P07203 ENST00000388829 K00432 1 0.78997 1.4116 0.79979 1.0219 0.95206 1.0231 Peptidase_M16;Peptidase_M16_C cell part;cytoplasmic part;intracellular organelle part;intracellular part;mitochondrial matrix;mitochondrial part;organelle part binding;catalytic activity;cation binding;endopeptidase activity;hydrolase activity;ion binding;metal ion binding;metalloendopeptidase activity;metallopeptidase activity;peptidase activity;transition metal ion binding;zinc ion binding biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis 18 18 18 43.4 43.4 43.4 54.366 0 1244200000 592610000 651630000 5673 IPI:IPI00927892.1 Mitochondrial-processing peptidase subunit beta;Beta-MPP;P-52 PMPCB;MPPB O75439 ENST00000249269 K01412 1 0.72534 1.9485 0.88871 1.0382 1.0614 1.1266 Bromodomain 3 3 3 8 8 8 66.999 1.1997E-16 18577000 9272000 9305100 5674 IPI:IPI00930290.1;IPI:IPI00549384.2;IPI:IPI00759680.3;IPI:IPI00479047.2 Bromodomain-containing protein 9;Rhabdomyosarcoma antigen MU-RMS-40.8 BRD9;UNQ3040/PRO9856 Q9H8M2-5;Q9H8M2 ENST00000323510;ENST00000323547;ENST00000388890 4 0.94729 1.485 0.94767 1.2448 0.99019 1.2494 Aminotran_5 binding;catalytic activity;lipid binding;O-phospho-L-serine:2-oxoglutarate aminotransferase activity;steroid binding;transaminase activity;transferase activity;transferase activity, transferring nitrogenous groups;vitamin binding cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;L-serine biosynthetic process;L-serine metabolic process;organic acid metabolic process;vitamin metabolic process;water-soluble vitamin metabolic process Glycine, serine and threonine metabolism;Vitamin B6 metabolism 24 24 24 59.7 59.7 59.7 40.422 0 7154100000 3562600000 3591600000 5675 IPI:IPI00930609.1;IPI:IPI00219478.3 Phosphoserine aminotransferase;Phosphohydroxythreonine aminotransferase PSAT1;PSA Q9Y617-1;Q9Y617;Q9Y617-2 ENST00000347159;ENST00000376588 K00831 2 0.83328 1.3979 0.80798 1.0476 0.99681 0.96251 SRCR cell part;extracellular region;membrane molecular transducer activity;receptor activity;scavenger receptor activity;signal transducer activity;transmembrane receptor activity 4 4 4 19.4 19.4 19.4 25.091 1.0114E-14 55261000 29359000 25903000 5676 IPI:IPI00935213.1 Putative scavenger receptor cysteine-rich domain-containing protein LOC619207 Q4G0T1 ENST00000333815 1 0.99038 1.6777 1.0193 1.2798 1.1245 1.2719 HSBP1 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding;transcription cofactor activity;transcription corepressor activity;transcription factor binding;transcription regulator activity;transcription repressor activity negative regulation of biosynthetic process;negative regulation of transcription from RNA polymerase II promoter;regulation of biosynthetic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent 2 2 2 39.5 39.5 39.5 8.5435 6.7874E-61 65288000 33413000 31874000 5677 IPI:IPI00935516.1 Heat shock factor-binding protein 1;Nasopharyngeal carcinoma-associated antigen 13 HSBP1;HSF1BP O75506 ENST00000299671 1 0.69763 1.6018 0.74856 0.8772 1.0734 0.97076 OTU 6 6 6 29.7 29.7 29.7 33.812 3.0024E-63 112950000 57449000 55502000 5678 IPI:IPI00935722.1 OTU domain-containing protein 6B;DUBA-5 OTUD6B;DUBA5;CGI-77 Q8N6M0 ENST00000285420;ENST00000404789 1 0.96249 1.7571 0.8936 1.25 1.15 1.1432 cell part;cytoplasmic part;cytosol;intracellular part binding;protein binding anti-apoptosis;negative regulation of peptidase activity;regulation of apoptosis;regulation of cell death;reproductive process;response to biotic stimulus;response to virus;viral genome replication;viral reproductive process 2 2 2 37.4 37.4 37.4 9.6138 1.6123E-144 276920000 150710000 126210000 5679 IPI:IPI00935729.1 Hepatitis B virus X-interacting protein HBXIP;XIP O43504 ENST00000256644;ENST00000369775 1 NaN 1.5803 0.93793 NaN 1.1121 1.1566 C8;Cys_knot;TIL;VWC;VWD extracellular region binding;enzyme inhibitor activity;enzyme regulator activity;extracellular matrix structural constituent;peptidase inhibitor activity;protein binding;structural molecule activity biological adhesion;cell adhesion;cellular process 2 2 2 0.7 0.7 0.7 590.78 0.0059722 4640600 1806700 2833900 5680 IPI:IPI00936444.2 Mucin-5B;Mucin-5 subtype B, tracheobronchial;High molecular weight salivary mucin MG1;Sublingual gland mucin;Cervical mucin MUC5B;MUC5 Q9HC84 ENST00000349637 1 0.83078 1.6282 0.9064 1.0934 1.1126 1.1779 LAP1C cell part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;nuclear inner membrane;nuclear membrane;nuclear part;organelle inner membrane;organelle membrane;organelle part 11 11 11 26.8 26.8 26.8 66.248 3.5448E-180 705000000 367600000 337400000 5681 IPI:IPI00936738.1;IPI:IPI00012280.4 Torsin-1A-interacting protein 1 TOR1AIP1 Q5JTV8-1;Q5JTV8 ENST00000271583;ENST00000325993;ENST00000398836 2 0.66603 1.4438 0.66002 0.85738 0.86844 0.86703 Band_7 cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part 5 3 3 18.5 11.6 11.6 38.925 4.8632E-70 7668500 4346000 3322500 5682 IPI:IPI00936931.1 Erlin-1;Endoplasmic reticulum lipid raft-associated protein 1;Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1;Protein KE04 ERLIN1;C10orf69;KE04;KEO4;SPFH1 O75477 ENST00000370408;ENST00000370410;ENST00000407654 1 0.86389 1.5736 0.76777 1.0938 1.041 0.98988 SAC3_GANP cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;proteasome regulatory particle;protein complex binding;protein binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;proteasomal protein catabolic process;protein metabolic process;proteolysis;ubiquitin-dependent protein catabolic process Proteasome 10 10 10 47.1 47.1 47.1 30.004 7.9892E-102 1113900000 587790000 526070000 5683 IPI:IPI00937278.1 26S proteasome non-ATPase regulatory subunit 8;26S proteasome regulatory subunit S14;p31 PSMD8 P48556 ENST00000215071;ENST00000404323 K03031 1 0.45506 0.79492 0.36559 0.60652 0.49947 0.48536 NUC189;WD40 cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part 10 10 10 18 18 18 74.89 6.0347E-70 137100000 73346000 63750000 5685 IPI:IPI00937477.1 WD repeat-containing protein 43 WDR43;KIAA0007 Q15061 ENST00000296126;ENST00000407426 1 0.76972 1.4663 0.75437 1.001 0.97513 0.97077 EF1G;GST_C;GST_N cell part;cytoplasmic part;cytosol;eukaryotic translation elongation factor 1 complex;intracellular part;macromolecular complex;protein complex binding;nucleic acid binding;protein binding;translation elongation factor activity;translation factor activity, nucleic acid binding;translation regulator activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation 29 29 29 58.4 58.4 58.4 50.118 0 12697000000 6663100000 6034200000 5686 IPI:IPI00937615.2 Elongation factor 1-gamma;eEF-1B gamma EEF1G;EF1G;PRO1608 P26641 ENST00000329251;ENST00000378019 K03233 1 0.64521 1.2428 0.83112 0.83786 0.79148 1.2008 WD40 apoptosis;cell death;cellular process;death;programmed cell death 10 10 10 31.4 31.4 31.4 39.74 2.6171E-35 318280000 82004000 236280000 5687 IPI:IPI00937835.1 WD repeat-containing protein 92;WD repeat-containing protein Monad WDR92 Q96MX6 ENST00000295121 1 0.74519 1.5231 0.67229 0.9167 1.1051 0.8707 ALAD cell part;cytoplasmic part;cytosol;intracellular part binding;carbon-oxygen lyase activity;catalytic activity;cation binding;hydro-lyase activity;ion binding;lyase activity;metal ion binding;porphobilinogen synthase activity;transition metal ion binding;zinc ion binding biosynthetic process;cellular process;heme biosynthetic process;heterocycle biosynthetic process;metabolic process;nitrogen compound metabolic process;porphyrin biosynthetic process;porphyrin metabolic process;tetrapyrrole metabolic process Porphyrin and chlorophyll metabolism 8 8 8 27.9 27.9 27.9 36.294 5.9316E-52 66828000 35749000 31078000 5689 IPI:IPI00937974.1;IPI:IPI00442121.4 Delta-aminolevulinic acid dehydratase;Porphobilinogen synthase ALAD P13716-1;P13716;P13716-2 ENST00000277315;ENST00000374173;ENST00000409155 K01698 2 0.93145 1.8667 1.0317 1.2419 1.2113 1.3182 efhand binding;calcium ion binding;cation binding;ion binding;metal ion binding 12 12 11 19 19 19 86.661 2.5329E-111 68492000 29859000 38633000 5690 IPI:IPI00940373.2;IPI:IPI00938352.2;IPI:IPI00783030.3 RalBP1-associated Eps domain-containing protein 1;RalBP1-interacting protein 1 REPS1 Q96D71-1;Q96D71;Q96D71-3;Q96D71-2 ENST00000258062;ENST00000367663;ENST00000367672 3 0.85028 1.3774 NaN 1.0437 0.94136 NaN F420_oxidored binding;catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on the CH-NH group of donors;oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor;pyrroline-5-carboxylate reductase activity cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;metabolic process;nitrogen compound metabolic process;organic acid metabolic process;proline biosynthetic process;proline metabolic process 6 6 6 27.7 27.7 27.7 28.649 8.2706E-56 52226000 28901000 23325000 5691 IPI:IPI00939144.1 Pyrroline-5-carboxylate reductase 3;Pyrroline-5-carboxylate reductase-like protein PYCRL Q53H96 ENST00000220966;ENST00000377579 1 0.15913 0.75797 0.27315 0.19932 0.51571 0.35598 FERM_M;IQ;Myosin_head;MyTH4;SH3_2 apical plasma membrane;cell part;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;myosin complex;organelle part;plasma membrane part;protein complex actin binding;ATP binding;binding;catalytic activity;cytoskeletal protein binding;hydrolase activity;motor activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity 5 5 5 2.6 2.6 2.6 241.6 1.4923E-26 116540000 52967000 63574000 5692 IPI:IPI00939150.1;IPI:IPI00889512.1 Myosin-VIIb MYO7B Q6PIF6-1;Q6PIF6;Q6PIF6-2 ENST00000272666;ENST00000389524;ENST00000409816 K10359 2 0.61789 1.1677 0.62987 0.83514 0.78125 0.84845 Nucleoside_tran cell fraction;cell part;insoluble fraction;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane fraction;membrane part;plasma membrane part binding;nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity;nucleoside transmembrane transporter activity;protein binding;transmembrane transporter activity;transporter activity cellular process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid transport;nucleoside transport;transport 7 7 7 16.4 16.4 16.4 50.219 1.5807E-45 153290000 83674000 69620000 5693 IPI:IPI00939219.1 Equilibrative nucleoside transporter 1;Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter;Nucleoside transporter, es-type;Solute carrier family 29 member 1 SLC29A1;ENT1 Q99808 ENST00000313248;ENST00000371708;ENST00000371713;ENST00000371724;ENST00000371731;ENST00000371740;ENST00000371755;ENST00000393841;ENST00000393844 K03323 1 0.6161 1.3076 0.64271 0.74667 0.93917 0.80238 FATC;HEAT;PI3_PI4_kinase cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity DNA metabolic process;DNA repair;nuclear-transcribed mRNA catabolic process;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA catabolic process 5 4 4 1.6 1.4 1.4 410.5 2.3305E-52 15295000 8579500 6715700 5695 IPI:IPI00939320.1;IPI:IPI00639874.2;IPI:IPI00183368.7;IPI:IPI00640955.1;IPI:IPI00878277.2;IPI:IPI00413300.1 Serine/threonine-protein kinase SMG1;Lambda/iota protein kinase C-interacting protein;61E3.4 SMG1;ATX;KIAA0421;LIP Q96Q15-1;Q96Q15;Q96Q15-2;Q96Q15-3 ENST00000389467 K08873 6 1.84 3.8672 2.0435 2.4272 2.4429 2.6828 HSP70 adenyl nucleotide binding;adenyl ribonucleotide binding;ATP binding;binding;nucleoside binding;nucleotide binding;purine nucleoside binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding response to biotic stimulus;response to chemical stimulus;response to organic substance;response to protein stimulus;response to stimulus;response to stress;response to unfolded protein Antigen processing and presentation;MAPK signaling pathway 11 2 2 18.1 2.5 2.5 70.374 4.7065E-245 676230000 308480000 367750000 5696 IPI:IPI00939442.1 Heat shock 70 kDa protein 1L;Heat shock 70 kDa protein 1-like;Heat shock 70 kDa protein 1-Hom;HSP70-Hom HSPA1L P34931 ENST00000375654 K03283 1 0.49724 0.82502 0.45442 0.60504 0.57607 0.59746 TPR_1 cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding catabolic process;cellular process;macromolecule catabolic process;metabolic process;mitosis;nuclear division;organelle organization;proteasomal protein catabolic process;proteolysis;ubiquitin-dependent protein catabolic process 11 11 11 21.2 21.2 21.2 63.132 6.3861E-112 218250000 123300000 94951000 5697 IPI:IPI00939488.1 Anaphase-promoting complex subunit 7;Cyclosome subunit 7 ANAPC7;APC7 Q9UJX3 ENST00000354390 1 0.66625 1.2926 0.63768 0.8807 0.85023 0.82533 FTHFS;THF_DHG_CYH;THF_DHG_CYH_C cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle ATP binding;binding;catalytic activity;formate-tetrahydrofolate ligase activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding cellular aromatic compound metabolic process;coenzyme metabolic process;folic acid and derivative metabolic process;group transfer coenzyme metabolic process;metabolic process;one-carbon metabolic process;organic acid metabolic process Glyoxylate and dicarboxylate metabolism;One carbon pool by folate 27 26 25 35.1 34 33.4 105.79 0 1239300000 842160000 397130000 5698 IPI:IPI00939493.1;IPI:IPI00552054.4 Monofunctional C1-tetrahydrofolate synthase, mitochondrial;Formyltetrahydrofolate synthetase MTHFD1L;FTHFSDC1 Q6UB35-1;Q6UB35 ENST00000367321 K00288;K01491;K01938 2 0.76876 1.3917 0.75042 0.96598 0.92599 0.96111 BcrAD_BadFG ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;purine nucleotide binding;transferase activity;transferase activity, transferring phosphorus-containing groups alcohol metabolic process;amino sugar metabolic process;carbohydrate metabolic process;glucosamine metabolic process;mannosamine metabolic process;monosaccharide metabolic process;N-acetylglucosamine metabolic process;N-acetylmannosamine metabolic process Aminosugars metabolism 13 13 13 43.6 43.6 43.6 37.375 3.5218E-154 129400000 69925000 59477000 5699 IPI:IPI00939575.1 N-acetyl-D-glucosamine kinase;GlcNAc kinase NAGK Q9UJ70 ENST00000244204 K00884 1 0.30568 0.70462 NaN 0.39552 0.48456 NaN DNA_pol_B;DNA_pol_B_exo;DUF1744 cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;catalytic activity;chromatin binding;DNA binding;DNA-directed DNA polymerase activity;nucleic acid binding;nucleotide binding;protein binding;transferase activity;transferase activity, transferring phosphorus-containing groups;zinc ion binding DNA metabolic process;DNA replication;DNA synthesis during DNA repair;G1/S transition of mitotic cell cycle;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleotide-excision repair, DNA gap filling DNA replication;Nucleotide excision repair 6 6 6 3.4 3.4 3.4 261.51 3.0413E-58 60361000 31876000 28484000 5700 IPI:IPI00939602.1 DNA polymerase epsilon catalytic subunit A POLE;POLE1 Q07864 ENST00000320574 K02324 1 0.68556 1.6316 NaN 0.93321 0.99694 NaN DnaJ;DUF1977 cell part;cytoplasmic part;endoplasmic reticulum;integral to membrane;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;intrinsic to membrane;membrane part;membrane-bounded organelle;organelle binding;heat shock protein binding;protein binding;unfolded protein binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;primary metabolic process;protein folding;protein metabolic process 6 6 6 19.7 19.7 19.7 41.859 9.1746E-48 8606600 4861300 3745300 5701 IPI:IPI00939657.1 DnaJ homolog subfamily B member 12 DNAJB12 Q9NXW2 ENST00000338820;ENST00000394903 K09518 1 0.65261 1.0516 0.61964 0.85567 0.72714 0.79967 binding 21 21 21 17.9 17.9 17.9 146.67 8.774E-139 632260000 355610000 276650000 5702 IPI:IPI00939707.1;IPI:IPI00001516.1;IPI:IPI00218806.1 Protein KIAA0664 KIAA0664 O75153 ENST00000322335 K03255 3 0.57819 1.039 0.49702 0.7216 0.70198 0.65602 BIR;UQ_con cell part;intracellular binding;cysteine-type endopeptidase inhibitor activity;endopeptidase inhibitor activity;enzyme inhibitor activity;enzyme regulator activity;peptidase inhibitor activity;protein binding anti-apoptosis;apoptosis;catabolic process;cell death;cellular process;death;macromolecule catabolic process;metabolic process;programmed cell death;protein modification process;proteolysis;regulation of cell death;regulation of metabolic process Ubiquitin mediated proteolysis 11 11 10 2.3 2.3 2.2 527.6 2.9496E-56 21268000 11553000 9714800 5703 IPI:IPI00939720.1;IPI:REV_IPI00060146.6 Baculoviral IAP repeat-containing protein 6;Ubiquitin-conjugating BIR domain enzyme apollon BIRC6;KIAA1289 Q9NR09 ENST00000261359 K10586 2 0.47147 0.87964 0.57437 0.61699 0.61697 0.71087 cell part;cytoplasmic part;cytosol;intracellular organelle part;intracellular part;macromolecular complex;membrane part;nuclear part;nuclear pore;organelle part;pore complex;protein complex binding;nucleic acid binding;protein transporter activity;RNA binding;RNA cap binding;substrate-specific transporter activity;transporter activity cellular process;intracellular protein transport;nucleocytoplasmic transport;protein import;protein import into nucleus;protein targeting;protein transport;ribonucleoprotein complex biogenesis;spliceosomal snRNP biogenesis;transport 4 4 4 14.2 14.2 14.2 41.142 4.2139E-18 39244000 22669000 16575000 5704 IPI:IPI00939743.1 Snurportin-1;RNA U transporter 1 SNUPN;RNUT1;SPN1 O95149 ENST00000308588;ENST00000371091;ENST00000394932 1 0.8498 1.6239 0.85111 1.1378 1.0778 1.1374 Fe-S_biosyn cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle binding;cation binding;ion binding;iron ion binding;iron-sulfur cluster binding;metal cluster binding;metal ion binding;structural molecule activity;transition metal ion binding biosynthetic process;cellular biosynthetic process;cellular metabolic process;cellular process;cofactor biosynthetic process;cofactor metabolic process;iron-sulfur cluster assembly;metabolic process;metallo-sulfur cluster assembly 3 3 3 31 31 31 14.179 1.4818E-07 61264000 32106000 29158000 5705 IPI:IPI00939800.1 Iron-sulfur cluster assembly 1 homolog, mitochondrial;HESB-like domain-containing protein 2;Iron sulfur assembly protein IscA ISCA1;HBLD2;GK004 Q9BUE6 ENST00000375991 1 0.92652 1.7425 0.89075 1.2442 1.1826 1.1966 Adaptin_N;Alpha_adaptinC2 AP-type membrane coat adaptor complex;clathrin adaptor complex;clathrin coated vesicle membrane;coated vesicle membrane;cytoplasmic vesicle membrane;cytosol;macromolecular complex;membrane;organelle membrane;organelle part;protein complex;vesicle membrane binding;protein binding;protein transporter activity;substrate-specific transporter activity;transporter activity cellular component organization;cellular process;endocytosis;establishment of protein localization;intracellular protein transport;intracellular transport;membrane invagination;membrane organization;protein transport;transport;vesicle-mediated transport 15 15 15 22.6 22.6 22.6 91.35 0 485900000 245280000 240620000 5707 IPI:IPI00939879.1 AP-1 complex subunit gamma-1;Adapter-related protein complex 1 subunit gamma-1;Adaptor protein complex AP-1 subunit gamma-1;Golgi adaptor HA1/AP1 adaptin subunit gamma-1;Gamma1-adaptin;Clathrin assembly protein complex 1 gamma-1 large chain AP1G1;ADTG;CLAPG1 O43747 ENST00000299980;ENST00000393512 1 0.14962 NaN NaN 0.19925 NaN NaN C1-set extracellular region antigen binding;binding;protein binding immune response;immune system process;response to stimulus 3 3 3 23.5 23.5 23.5 25.451 4.7415E-132 15232000 15018000 214660 5708 IPI:IPI00940069.1 Ig kappa chain C region IGKC P01834 ENST00000390237 1 0.71265 1.3282 0.83283 0.93413 0.90989 1.0212 cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;membrane;membrane part;nuclear membrane;nuclear part;nuclear pore;nucleoplasm;organelle membrane;organelle part;pore complex;protein complex cellular process;establishment of protein localization;intracellular protein transport;intracellular transport;mRNA transport;nucleic acid transport;nucleobase, nucleoside, nucleotide and nucleic acid transport;protein transport;RNA transport;transport 10 10 10 24.5 24.5 24.5 55.435 8.076E-209 392340000 207170000 185170000 5709 IPI:IPI00940095.1;IPI:IPI00386702.1 Nucleoporin p54;54 kDa nucleoporin NUP54 Q7Z3B4-1;Q7Z3B4;Q7Z3B4-2 ENST00000264883;ENST00000342467 2 0.76063 1.5212 0.79688 1.0441 0.97039 1.0474 GDI cell part;cell surface;cytoplasm;intracellular part;membrane enzyme activator activity;enzyme regulator activity;GDP-dissociation inhibitor activity;GTPase activator activity;GTPase regulator activity;Rab GDP-dissociation inhibitor activity;small GTPase regulator activity cell communication;cellular process;establishment of protein localization;protein transport;regulation of biological process;regulation of catalytic activity;regulation of cellular process;regulation of GTPase activity;signal transduction;transport 49 49 38 91.5 91.5 73.7 50.663 0 7026000000 3689800000 3336300000 5710 IPI:IPI00940148.1 Rab GDP dissociation inhibitor beta;Guanosine diphosphate dissociation inhibitor 2 GDI2;RABGDIB P50395 ENST00000380191 1 0.69759 1.1761 0.68815 0.91085 0.8185 0.89922 FAST_1;FAST_2;RAP cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;purine nucleoside binding;transferase activity;transferase activity, transferring phosphorus-containing groups apoptosis;cell cycle arrest;cell cycle phase;cell cycle process;cell death;cellular process;death;G1 phase of mitotic cell cycle;positive regulation of cell proliferation;programmed cell death;regulation of cell proliferation 11 11 11 26 26 26 70.737 5.6432E-145 387260000 214700000 172560000 5711 IPI:IPI00940204.1;IPI:IPI00477123.2 Protein TBRG4;Transforming growth factor beta regulator 4;Cell cycle progression restoration protein 2;FAST kinase domain-containing protein 4 TBRG4;CPR2;FASTKD4;KIAA0948 Q969Z0-1;Q969Z0;Q969Z0-2 ENST00000258770;ENST00000361278;ENST00000395655;ENST00000404564 2 0.75382 1.2992 0.75498 1.0174 0.87752 0.94103 DEAD;Helicase_C cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;ATP-dependent helicase activity;binding;catalytic activity;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 23 8 8 52.7 27.6 27.6 49.129 2.1295E-227 583680000 308510000 275170000 5712 IPI:IPI00940237.1 ATP-dependent RNA helicase DDX39;DEAD box protein 39;Nuclear RNA helicase URH49 DDX39 O00148 ENST00000242776 1 0.79026 1.4134 0.78872 0.99226 0.96442 0.97325 GalKase_gal_bdg;GHMP_kinases_C;GHMP_kinases_N cell part;cytoplasmic part;cytosol;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle ATP binding;binding;catalytic activity;galactokinase activity;galactose binding;kinase activity;nucleoside binding;nucleotide binding;purine nucleoside binding;sugar binding;transferase activity alcohol metabolic process;carbohydrate metabolic process;cellular process;galactose metabolic process;hexose metabolic process;metabolic process;monosaccharide metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation Galactose metabolism 13 13 13 38 38 38 42.272 2.7662E-146 374380000 201950000 172430000 5713 IPI:IPI00940264.1 Galactokinase;Galactose kinase GALK1;GALK P51570 ENST00000225614;ENST00000375188 K00849 1 0.96888 1.6216 0.93147 1.1897 1.134 1.2421 ATP_bind_1 cell part;cytoplasm;intracellular part binding;catalytic activity;GTP binding;hydrolase activity;hydrolase activity, acting on acid anhydrides;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleotide binding;protein binding;pyrophosphatase activity 4 4 4 14.7 14.7 14.7 41.74 1.3707E-224 71044000 27928000 43116000 5714 IPI:IPI00940277.1 GPN-loop GTPase 1;XPA-binding protein 1;MBD2-interacting protein GPN1;MBDIN;XAB1;HUSSY-23 Q9HCN4 ENST00000264718 K06883 1 0.56923 1.4866 0.77417 0.81607 0.89536 1.0164 MATH;zf-C3HC4;zf-TRAF centrosome;cytoplasmic part;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;microtubule organizing center;non-membrane-bounded organelle;organelle;organelle part binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding apoptosis;cell communication;cell death;cellular process;positive regulation of signal transduction;regulation of cell communication;regulation of protein kinase cascade;regulation of signal transduction;signal transduction Pathways in cancer;Small cell lung cancer 2 2 2 4.5 4.5 4.5 64.405 7.3219E-09 4193100 2470700 1722300 5715 IPI:IPI00940298.1 TNF receptor-associated factor 5;RING finger protein 84 TRAF5;RNF84 O00463 ENST00000261464;ENST00000336184;ENST00000367004 K09849 1 0.92731 2.0765 0.75541 1.16 1.4303 1.1057 CBS;Voltage_CLC cell part;integral to membrane;intrinsic to membrane;membrane part anion channel activity;anion transmembrane transporter activity;binding;chloride channel activity;ion channel activity;transporter activity;voltage-gated anion channel activity;voltage-gated chloride channel activity;voltage-gated ion channel activity anion transport;chloride transport;establishment of localization;inorganic anion transport;ion transport;transport 4 4 4 5.1 5.1 5.1 88.678 2.2216E-10 24422000 14164000 10258000 5716 IPI:IPI00940305.1 Chloride channel protein 7 CLCN7 P51798 ENST00000262318;ENST00000382745 1 0.73322 1.423 0.83627 0.98264 0.90426 1.1195 YTH cell part;cytoplasm;intracellular part 7 5 3 13.7 10.9 6.5 63.86 1.0853E-73 75701000 39284000 36417000 5717 IPI:IPI00940386.1 YTH domain family protein 3 YTHDF3 Q7Z739 ENST00000339066 1 0.60796 1.0463 0.56054 0.77374 0.72515 0.70488 tRNA_int_endo intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part;protein complex;tRNA-intron endonuclease complex binding;catalytic activity;endonuclease activity;endoribonuclease activity;hydrolase activity;nuclease activity;nucleic acid binding;ribonuclease activity;tRNA-intron endonuclease activity;tRNA-specific ribonuclease activity cellular process;metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;tRNA-type intron splice site recognition and cleavage 6 6 6 21.9 21.9 21.9 33.652 4.3444E-62 20495000 11180000 9314700 5718 IPI:IPI00940410.1 tRNA-splicing endonuclease subunit Sen34;tRNA-intron endonuclease Sen34;Leukocyte receptor cluster member 5 TSEN34;LENG5;SEN34 Q9BSV6 ENST00000302937;ENST00000396383;ENST00000396388 K01170 1 0.14027 0.34728 0.14588 0.17333 0.22991 0.18334 Pkinase_Tyr;SH2;SH3_1 cytoskeletal part;cytosol;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane part;membrane-bounded organelle;organelle;organelle part;pericentriolar material;plasma membrane catalytic activity;glycoprotein binding;non-membrane spanning protein tyrosine kinase activity;nucleoside binding;nucleotide binding;phosphoprotein phosphatase activity;protein kinase activity;protein tyrosine kinase activity;purine nucleoside binding calcium ion transport;cation transport;cell activation;cellular ion homeostasis;immune system process;ion transport;leukocyte differentiation;positive regulation of immune system process;regulation of immune system process;transport Natural killer cell mediated cytotoxicity;Primary immunodeficiency;T cell receptor signaling pathway 18 18 17 52.8 52.8 50.9 58 0 1769700000 1189400000 580300000 5719 IPI:IPI00940423.1;IPI:IPI00515097.3;IPI:IPI00411413.2 Proto-oncogene tyrosine-protein kinase LCK;Lymphocyte cell-specific protein-tyrosine kinase;p56-LCK;LSK;T cell-specific protein-tyrosine kinase LCK P06239-1;P06239;P06239-3;P06239-2 ENST00000336890;ENST00000373562;ENST00000398345 K05856 3 0.61468 1.0939 0.68829 0.8156 0.74779 0.9169 M20_dimer;Peptidase_M20 cell part;cytoplasmic part;cytosol;intracellular part aminoacylase activity;binding;catalytic activity;hydrolase activity;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;metallopeptidase activity;peptidase activity;protein binding;zinc ion binding catabolic process;cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;macromolecule catabolic process;metabolic process;nitrogen compound metabolic process;organic acid metabolic process;proteolysis Arginine and proline metabolism 6 6 6 16.4 16.4 16.4 45.884 1.4806E-15 19690000 11331000 8359200 5720 IPI:IPI00940464.1 Aminoacylase-1;N-acyl-L-amino-acid amidohydrolase;ACY-1 ACY1 Q03154 ENST00000232907;ENST00000404366 K01436 1 0.8683 1.511 0.85028 1.1383 0.91216 1.0729 MAD centrosome;cytosol;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;microtubule organizing center;non-membrane-bounded organelle;nucleus;organelle;spindle binding;protein binding cell cycle checkpoint;cell cycle phase;cell cycle process;cellular process;mitotic anaphase;mitotic cell cycle checkpoint;mitotic metaphase;mitotic telophase;regulation of biological process;regulation of cellular process;regulation of mitotic cell cycle Cell cycle 9 9 9 14.5 14.5 14.5 83.066 2.8454E-47 127160000 65692000 61469000 5721 IPI:IPI00940535.1 Mitotic spindle assembly checkpoint protein MAD1;Mitotic arrest deficient-like protein 1;MAD1-like 1;Mitotic checkpoint MAD1 protein homolog;Tax-binding protein 181 MAD1L1;MAD1;TXBP181 Q9Y6D9 ENST00000265854;ENST00000399654;ENST00000406869 K06638 1 0.67066 1.3276 0.68225 0.88874 0.84592 0.94169 WD40 cell part;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;small nuclear ribonucleoprotein complex;small nucleolar ribonucleoprotein complex;U5 snRNP binding;catalytic activity;protein binding;RNA splicing factor activity, transesterification mechanism nuclear mRNA splicing, via spliceosome;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 17 17 17 66.4 66.4 66.4 39.31 0 913270000 481880000 431380000 5722 IPI:IPI00940685.1 U5 small nuclear ribonucleoprotein 40 kDa protein;U5 snRNP-specific 40 kDa protein;38 kDa-splicing factor;WD repeat-containing protein 57;Prp8-binding protein SNRNP40;PRP8BP;SFP38;WDR57 Q96DI7 ENST00000263694 1 0.86704 1.2607 1.0075 1.114 0.76451 1.2707 Cadherin;EGF;Laminin_G_2 cell part;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part binding;calcium ion binding;cation binding;ion binding;metal ion binding;protein binding anatomical structure morphogenesis;biological adhesion;cell adhesion;cell communication;cell-cell adhesion;cell-cell signaling;cellular process;developmental process;homophilic cell adhesion 6 6 6 1.6 1.6 1.6 506.27 8.4018E-11 19990000 9467700 10523000 5723 IPI:IPI00940698.1 Protocadherin Fat 1;Cadherin-related tumor suppressor homolog;Protein fat homolog FAT1;CDHF7;FAT Q14517 ENST00000260147 1 0.90348 1.5762 0.88707 1.1892 1.0614 1.186 DUF1982;Fer2;Molybdopterin;NADH-G_4Fe-4S_3 intracellular part;macromolecular complex;membrane part;membrane-enclosed lumen;mitochondrial intermembrane space;mitochondrial respiratory chain complex I;NADH dehydrogenase complex;organelle envelope lumen;organelle part;protein complex binding;catalytic activity;electron carrier activity;iron ion binding;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;protein binding generation of precursor metabolites and energy;mitochondrial electron transport, NADH to ubiquinone;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;purine nucleotide metabolic process Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 27 27 27 46.1 46.1 46.1 79.467 0 728840000 376840000 352000000 5724 IPI:IPI00940744.1 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial;Complex I-75kD NDUFS1 P28331 ENST00000233190 K03934 1 0.69048 1.2346 0.69016 0.90661 0.83257 0.86829 MCM alpha DNA polymerase:primase complex;cell part;chromosomal part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear chromosome part;nuclear part;nucleoplasm;organelle part;protein complex ATP binding;binding;catalytic activity;DNA binding;hydrolase activity;hydrolase activity, acting on acid anhydrides;nucleic acid binding;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity cell cycle;DNA metabolic process;DNA replication initiation;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription Cell cycle;Cell cycle - yeast;DNA replication 37 37 37 50.7 50.7 50.7 90.98 0 3711000000 1969900000 1741100000 5725 IPI:IPI00940786.1 DNA replication licensing factor MCM3;DNA polymerase alpha holoenzyme-associated protein P1;RLF subunit beta;P102 protein;P1-MCM3 MCM3 P25205 ENST00000229854 K02541 1 0.66151 1.722 NaN 0.82295 1.1344 NaN Torsin endoplasmic reticulum;endoplasmic reticulum lumen;intracellular membrane-bounded organelle;intracellular organelle;membrane;membrane-bounded organelle;membrane-enclosed lumen;nuclear membrane;organelle;organelle lumen;organelle membrane;organelle part ATP binding;binding;catalytic activity;endopeptidase activity;hydrolase activity;nucleoside binding;nucleotide binding;peptidase activity;protein binding;purine nucleoside binding;serine-type endopeptidase activity;serine-type peptidase activity cellular biopolymer metabolic process;cellular process;'de novo' protein folding;metabolic process;protein folding;protein metabolic process;response to biotic stimulus;response to organic substance;response to stress;response to unfolded protein 9 9 9 27.7 27.7 27.7 37.808 3.7821E-58 23330000 12421000 10909000 5726 IPI:IPI00940790.1;IPI:IPI00386422.3 Torsin-1A;Torsin family 1 member A;Dystonia 1 protein TOR1A;DQ2;DYT1 O14656-1;O14656 ENST00000351698 2 1.1062 1.3213 NaN 1.4798 0.84993 NaN Metallophos;Mre11_DNA_bind cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part catalytic activity;DNA binding;double-stranded DNA binding;endodeoxyribonuclease activity;endonuclease activity;exonuclease activity;nuclease activity;nucleic acid binding;single-stranded DNA specific endodeoxyribonuclease activity DNA metabolic process;DNA replication;non-recombinational repair;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of DNA recombination;regulation of mitotic recombination;RNA-dependent DNA replication;telomere maintenance 3 3 3 4.1 4.1 4.1 80.592 2.0612E-09 5958000 3214000 2744000 5727 IPI:IPI00940798.1;IPI:IPI00218853.1 Double-strand break repair protein MRE11A;MRE11 meiotic recombination 11 homolog A;MRE11 homolog 1 MRE11A;HNGS1;MRE11 P49959-1;P49959;P49959-2 ENST00000323929;ENST00000323977;ENST00000393241;ENST00000407439 2 1.0798 1.8078 1.1676 1.415 1.2203 1.417 DNA_binding_1;Methyltransf_1N cell part;intracellular organelle part;intracellular part;nuclear part;nucleoplasm;organelle part binding;catalytic activity;DNA binding;DNA-methyltransferase activity;methylated-DNA-[protein]-cysteine S-methyltransferase activity;methyltransferase activity;nucleic acid binding;S-methyltransferase activity;transferase activity;zinc ion binding cellular biopolymer metabolic process;cellular process;DNA ligation;DNA metabolic process;macromolecule metabolic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 6 6 6 39.1 39.1 39.1 21.646 3.638E-241 221210000 111870000 109350000 5728 IPI:IPI00940824.1 Methylated-DNA--protein-cysteine methyltransferase;6-O-methylguanine-DNA methyltransferase;O-6-methylguanine-DNA-alkyltransferase MGMT P16455 ENST00000306010 1 0.81162 1.6585 0.9635 1.0473 1.145 1.2123 C2;HECT;WW apicolateral plasma membrane;cell cortex;cell fraction;chromatin;chromosomal part;cytoplasmic part;cytosol;insoluble fraction;intracellular part;macromolecular complex;membrane fraction;membrane part;organelle part;protein complex;ubiquitin ligase complex auxiliary transport protein activity;binding;catalytic activity;channel inhibitor activity;channel regulator activity;G-protein-coupled receptor binding;ion channel inhibitor activity;protein binding;receptor binding;ubiquitin-protein ligase activity negative regulation of transcription from RNA polymerase II promoter;protein modification process;protein targeting;regulation of sodium ion transport;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent Ubiquitin mediated proteolysis 5 5 4 6.6 6.6 5.4 104.16 7.7453E-45 35679000 19611000 16068000 5729 IPI:IPI00940829.2;IPI:IPI00945379.1;IPI:IPI00944928.1;IPI:IPI00384495.4 E3 ubiquitin-protein ligase NEDD4;Neural precursor cell expressed developmentally down-regulated protein 4 NEDD4;KIAA0093 P46934-4;P46934;P46934-1;P46934-2 ENST00000164316;ENST00000338963 K10591 4 0.8371 1.4416 0.82748 1.0844 1.0017 1.0644 RRM_1 binding;identical protein binding;mRNA binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding developmental process;multicellular organismal development;multicellular organismal process 15 15 15 54.6 54.6 54.6 36.091 2.5714E-302 3180000000 1628100000 1552000000 5730 IPI:IPI00940851.1;IPI:IPI00607677.1;IPI:IPI00479625.2;IPI:IPI00395507.4;IPI:IPI00644588.1;IPI:IPI00030250.4;IPI:IPI00219967.2 ELAV-like protein 1;Hu-antigen R ELAVL1;HUR Q15717 ENST00000351593;ENST00000407627 7 0.86058 1.3902 0.81828 1.1066 0.95918 1.0593 DUF1917 4 4 4 17.9 17.9 17.9 27.382 7.7704E-14 35755000 18957000 16798000 5731 IPI:IPI00940858.1 UPF0696 protein C11orf68;Basophilic leukemia-expressed protein Bles03;Protein p5326 C11orf68;BLES03 Q9H3H3 ENST00000312536 1 0.71054 1.3473 1.2263 0.94329 0.88684 1.6227 PHD cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;cation binding;ion binding;metal ion binding;protein binding;transition metal ion binding;zinc ion binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 3 3 3 11.5 11.5 11.5 46.646 5.4375E-102 4860400 2481600 2378800 5732 IPI:IPI00940864.1;IPI:IPI00941847.1 PHD finger protein 10;XAP135 PHF10 Q8WUB8-1;Q8WUB8;Q8WUB8-2 ENST00000252308;ENST00000339209;ENST00000366780 2 0.74574 1.4473 0.71159 0.98952 0.90418 0.95176 YLP cell part;intracellular organelle part;intracellular part;nuclear body;nuclear part;nuclear speck;nucleoplasm part;organelle part 19 19 19 11.4 11.4 11.4 219.98 6.6832E-132 333080000 176340000 156730000 5733 IPI:IPI00940874.1;IPI:IPI00514265.1;IPI:IPI00181641.5 YLP motif-containing protein 1;Nuclear protein ZAP3;ZAP113 YLPM1;C14orf170;ZAP3 P49750-1;P49750;P49750-3;P49750-2 ENST00000238571;ENST00000325680 3 0.5161 0.81122 0.55324 0.64818 0.5463 0.69883 Hist_deacetyl;zf-UBP cell part;chromatin remodeling complex;cytoplasm;cytoskeletal part;histone deacetylase complex;intracellular organelle part;intracellular part;macromolecular complex;microtubule;nuclear part;nucleoplasm part;organelle part;protein complex actin binding;binding;catalytic activity;cytoskeletal protein binding;hydrolase activity;protein binding;specific transcriptional repressor activity;transcription repressor activity;zinc ion binding chromatin organization;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein amino acid deacetylation;protein modification process;regulation of transcription, DNA-dependent;transcription 4 4 4 3.3 3.3 3.3 131.42 7.3938E-24 34509000 18649000 15859000 5734 IPI:IPI00940882.1 Histone deacetylase 6 HDAC6;KIAA0901;JM21 Q9UBN7 ENST00000334136;ENST00000376619 K11407 1 1.0174 1.8588 0.96164 1.3573 1.2122 1.309 Arf cell part;cytoplasmic part;cytoskeletal part;endosomal part;endosome membrane;intracellular organelle part;intracellular part;late endosome membrane;lysosomal membrane;membrane;midbody;organelle membrane;organelle part;vacuolar membrane;vacuolar part binding;catalytic activity;cytoskeletal protein binding;GTP binding;GTPase activity;hydrolase activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity;tubulin binding biological regulation;cell communication;cellular process;chromosome segregation;intracellular signaling cascade;regulation of biological process;regulation of cellular process;signal transduction;small GTPase mediated signal transduction 8 8 5 40.9 40.9 21.5 21.539 2.5915E-130 475600000 241340000 234260000 5735 IPI:IPI00940959.1 ADP-ribosylation factor-like protein 8B;ADP-ribosylation factor-like protein 10C;Novel small G protein indispensable for equal chromosome segregation 1 ARL8B;ARL10C;GIE1 Q9NVJ2 ENST00000256496 K07956 1 0.93942 2.1373 NaN 1.2768 1.3629 NaN E1_DerP2_DerF2 cell part;cytoplasmic part;extracellular region;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;lysosome;lytic vacuole;membrane-bounded organelle;nucleus;organelle;vacuole binding;cholesterol binding;enzyme binding;lipid binding;protein binding;steroid binding;sterol binding cholesterol transport;lipid transport;phospholipid transport;regulation of cellular metabolic process;regulation of isoprenoid metabolic process;regulation of lipid metabolic process;regulation of metabolic process;sterol transport;transport 3 3 3 32.5 32.5 32.5 16.57 1.2037E-48 8047900 4658100 3389800 5736 IPI:IPI00940960.1 Epididymal secretory protein E1;Niemann-Pick disease type C2 protein NPC2 P61916 ENST00000238633 1 1.0263 1.3491 0.9814 1.2146 0.96149 1.3118 SAP18 cell part;chromatin remodeling complex;histone deacetylase complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;protein binding;transcription cofactor activity;transcription corepressor activity;transcription factor binding;transcription regulator activity;transcription repressor activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 2 2 2 17 17 17 17.561 1.0928E-100 137260000 64969000 72295000 5737 IPI:IPI00940972.1 Histone deacetylase complex subunit SAP18;Sin3-associated polypeptide, 18 kDa;Sin3-associated polypeptide p18;Cell growth-inhibiting protein 38;2HOR0202 SAP18;GIG38 O00422 ENST00000382533 1 0.89695 1.8286 0.82567 1.1913 1.2682 1.1092 PGM_PMM_I;PGM_PMM_IV binding;catalytic activity;cation binding;intramolecular transferase activity;intramolecular transferase activity, phosphotransferases;ion binding;isomerase activity;magnesium ion binding;metal ion binding;phosphoacetylglucosamine mutase activity alcohol metabolic process;amino sugar metabolic process;carbohydrate metabolic process;glucosamine metabolic process;metabolic process;monosaccharide metabolic process;primary metabolic process Aminosugars metabolism 7 7 7 14.2 14.2 14.2 59.851 3.1543E-38 64916000 36285000 28631000 5738 IPI:IPI00941001.1 Phosphoacetylglucosamine mutase;Acetylglucosamine phosphomutase;N-acetylglucosamine-phosphate mutase;Phosphoglucomutase 3 PGM3;AGM1 O95394 ENST00000283977;ENST00000369731 K01836 1 1.3415 2.5971 1.3199 1.8816 1.6363 1.8063 Sad1_UNC cell part;cytoplasmic part;endosomal part;endosome membrane;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;nuclear membrane;nuclear part;organelle membrane;organelle part binding;cytoskeletal protein binding;microtubule binding;protein binding;tubulin binding cellular process;cytoskeleton organization;microtubule cytoskeleton organization;microtubule-based process;mitotic spindle organization;nuclear envelope organization;nuclear migration;nucleus organization;organelle organization;spindle organization 8 8 8 18 18 18 80.31 1.461E-136 81373000 37795000 43578000 5739 IPI:IPI00941110.1 Protein unc-84 homolog B;Sad1/unc-84 protein-like 2;Rab5-interacting protein UNC84B;FRIGG;KIAA0668;RAB5IP;SUN2 Q9UH99 ENST00000216064;ENST00000396784;ENST00000405018;ENST00000405510;ENST00000406622 1 NaN 1.5392 1.1095 NaN 1.0027 1.4747 UPF0005 cell part;integral to membrane;intrinsic to membrane;membrane part 3 3 3 8.7 8.7 8.7 37.205 0.0006355 64500000 29043000 35457000 5740 IPI:IPI00941155.1 Growth hormone-inducible transmembrane protein;Dermal papilla-derived protein 2;Transmembrane BAX inhibitor motif-containing protein 5 GHITM;DERP2;TMBIM5;My021;UNQ244/PRO281 Q9H3K2 ENST00000372134 1 0.75396 1.6659 0.78669 1.0302 1.091 1.0726 Uso1_p115_C;Uso1_p115_head cell part;cytoplasmic part;cytosol;Golgi apparatus part;Golgi membrane;intracellular organelle part;intracellular part;membrane;organelle membrane;organelle part binding;protein binding cellular component organization;cellular process;membrane fusion;membrane organization;organelle fusion;organelle organization;vesicle fusion;vesicle fusion with Golgi apparatus;vesicle organization 27 27 27 34.6 34.6 34.6 107.89 0 1291200000 678870000 612330000 5742 IPI:IPI00941161.1;IPI:REV_IPI00746398.1;IPI:REV_IPI00100453.7;IPI:REV_IPI00386049.4 General vesicular transport factor p115;Protein USO1 homolog;Transcytosis-associated protein;Vesicle-docking protein USO1;VDP O60763 ENST00000264904 4 0.97036 1.8842 0.91077 1.3006 1.2394 1.213 Glyco_hydro_20;Glyco_hydro_20b cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;lysosome;lytic vacuole;membrane-bounded organelle;organelle;vacuole beta-N-acetylhexosaminidase activity;binding;catalytic activity;cation binding;hexosaminidase activity;hydrolase activity;hydrolase activity, acting on glycosyl bonds;hydrolase activity, hydrolyzing O-glycosyl compounds;ion binding;protein binding Aminosugars metabolism;Glycosaminoglycan degradation;Glycosphingolipid biosynthesis - ganglio series;Glycosphingolipid biosynthesis - globo series;Other glycan degradation 10 10 10 19.1 19.1 19.1 60.688 5.2079E-51 204770000 105420000 99344000 5743 IPI:IPI00941167.1 Beta-hexosaminidase subunit alpha;N-acetyl-beta-glucosaminidase subunit alpha;Beta-N-acetylhexosaminidase subunit alpha HEXA P06865 ENST00000268097 K12373 1 0.8548 2.0333 0.90403 1.1118 1.3819 1.1853 Plug_translocon;SecY cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane;membrane part;organelle membrane;organelle part binding;P-P-bond-hydrolysis-driven transmembrane transporter activity;primary active transmembrane transporter activity;protein binding;protein transmembrane transporter activity;protein transporter activity;transporter activity cellular process;establishment of localization;establishment of localization in cell;establishment of protein localization;intracellular protein transport;intracellular transport;protein transport;transmembrane transport;transport Vibrio cholerae infection 8 8 8 15.5 15.5 15.5 52.264 2.0772E-29 458090000 230340000 227750000 5744 IPI:IPI00941172.1;IPI:IPI00604476.1;IPI:IPI00414427.2;IPI:IPI00414428.7 Protein transport protein Sec61 subunit alpha isoform 1 SEC61A1;SEC61A P61619-1;P61619;P61619-3 ENST00000243253 K10956 4 0.72886 1.3472 0.71463 0.94616 0.92622 0.92968 Mov34 cell part;cytoplasmic part;cytosol;eukaryotic translation initiation factor 3 complex;intracellular part;macromolecular complex;protein complex binding;nucleic acid binding;protein binding;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity cellular process;translational initiation 11 11 11 37 37 37 37.563 0 2557700000 1353900000 1203800000 5746 IPI:IPI00941255.1 Eukaryotic translation initiation factor 3 subunit F;Eukaryotic translation initiation factor 3 subunit 5;eIF-3-epsilon;eIF3 p47 EIF3F;EIF3S5 O00303 ENST00000309828 K03249 1 0.5271 1.2847 0.60618 0.77356 0.85618 0.75336 C1_1;PH;Pkinase cell part;intracellular ATP binding;binding;catalytic activity;kinase activity;lipid binding;nucleoside binding;nucleotide binding;protein kinase activity;protein kinase C activity;protein serine/threonine kinase activity;purine nucleoside binding;zinc ion binding cell communication;cellular process;intracellular signaling cascade;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein modification process;signal transduction 10 10 9 16.6 16.6 15.7 96.721 3.0145E-31 62711000 33649000 29062000 5747 IPI:IPI00941257.1 Serine/threonine-protein kinase D2;nPKC-D2 PRKD2;PKD2;HSPC187 Q9BZL6 ENST00000291281 K06070 1 0.7948 1.5294 0.69316 1.0743 0.9893 0.9116 Mov34 cell part;cytoplasmic part;cytosol;eukaryotic translation initiation factor 3 complex;intracellular part;macromolecular complex;protein complex binding;nucleic acid binding;protein binding;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity cellular process;regulation of biosynthetic process;regulation of gene expression;regulation of macromolecule biosynthetic process;regulation of translation;regulation of translational initiation;translational initiation 17 17 17 44.3 44.3 44.3 39.93 7.5787E-260 486690000 262610000 224080000 5748 IPI:IPI00941359.1 Eukaryotic translation initiation factor 3 subunit H;Eukaryotic translation initiation factor 3 subunit 3;eIF-3 gamma;eIF3 p40 subunit EIF3H;EIF3S3 O15372 ENST00000276682 K03247 1 0.68267 1.4291 0.80891 0.92404 0.98126 1.0133 NAP cell part;chromatin assembly complex;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;protein complex binding;protein binding;unfolded protein binding anatomical structure formation;cellular component assembly;cellular component organization;cellular macromolecular complex subunit organization;cellular process;chromatin organization;nucleosome assembly;organelle organization 11 11 9 30.7 30.7 28 42.823 5.8759E-272 3456500000 1779600000 1676900000 5749 IPI:IPI00941463.1 Nucleosome assembly protein 1-like 4;Nucleosome assembly protein 2 NAP1L4;NAP2 Q99733 ENST00000380542;ENST00000399624 K11282 1 0.80858 1.2901 0.83955 1.0324 0.8658 1.198 Tetraspannin cell part;integral to membrane;integral to plasma membrane;intrinsic to membrane;intrinsic to plasma membrane;membrane part;plasma membrane part carbohydrate metabolic process;cellular biopolymer metabolic process;cellular process;metabolic process;protein amino acid glycosylation;protein amino acid N-linked glycosylation;protein metabolic process;protein modification process 2 2 2 9.6 9.6 9.6 27.574 2.6187E-53 55887000 29847000 26041000 5750 IPI:IPI00941552.1 Tetraspanin-7;Transmembrane 4 superfamily member 2;Cell surface glycoprotein A15;T-cell acute lymphoblastic leukemia-associated antigen 1;Membrane component, X chromosome, surface marker 1 TSPAN7;A15;DXS1692E;MXS1;TM4SF2 P41732 ENST00000286824 K06571 1 0.79047 1.3535 0.81374 1.0483 0.92196 1.0183 F420_oxidored cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle binding;catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on the CH-NH group of donors;oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor;pyrroline-5-carboxylate reductase activity cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;metabolic process;nitrogen compound metabolic process;organic acid metabolic process;proline biosynthetic process;proline metabolic process Arginine and proline metabolism 13 13 12 53.9 53.9 49.8 33.36 6.8281E-218 950470000 480670000 469800000 5751 IPI:IPI00941557.1 Pyrroline-5-carboxylate reductase 1, mitochondrial PYCR1 P32322 ENST00000329875;ENST00000405481 K00286 1 0.73334 1.4696 0.76099 0.94898 0.96462 0.97146 MA3;MIF4G;W2 cell part;cytoplasmic part;eukaryotic translation initiation factor 4F complex;intracellular part;macromolecular complex;protein complex binding;nucleic acid binding;protein binding;translation factor activity, nucleic acid binding;translation initiation factor activity;translation regulator activity biosynthetic process;cell cycle arrest;cell death;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of translation;regulation of translational initiation;translation 30 30 30 38.8 38.8 38.8 102.36 0 2339100000 1297700000 1041400000 5752 IPI:IPI00941589.1 Eukaryotic translation initiation factor 4 gamma 2;p97;Death-associated protein 5 EIF4G2;DAP5;OK/SW-cl.75 P78344 ENST00000339995 1 0.75631 1.4927 0.74695 1.0472 0.95135 1.0589 RRM_1 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;membrane-bounded organelle;mitochondrion;nuclear part;nucleoplasm;organelle;organelle part binding;nucleic acid binding;nucleotide binding;protein binding;RNA binding biosynthetic process;macromolecule biosynthetic process;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription 6 6 6 17.6 17.6 17.6 43.239 1.6942E-64 53387000 26629000 26758000 5753 IPI:IPI00941607.1 Negative elongation factor E;RNA-binding protein RD RDBP;NELFE;RD P18615 ENST00000375429;ENST00000383174;ENST00000383343 1 NaN NaN 0.65238 NaN NaN 0.9516 Elongin_A;TFIIS cell part;cytoplasm;integral to membrane;intracellular organelle part;intracellular part;intrinsic to membrane;membrane part;nuclear part;nucleoplasm;organelle part binding;DNA binding;nucleic acid binding;protein binding;transcription regulator activity metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 2 2 2 3.6 3.6 3.6 87.229 5.6843E-06 42208000 23579000 18629000 5754 IPI:IPI00941732.1 Transcription elongation factor B polypeptide 3;RNA polymerase II transcription factor SIII subunit A1;SIII p110;Elongin-A;Elongin 110 kDa subunit TCEB3;MSTP059 Q14241 ENST00000374536 1 0.88015 1.814 0.87383 1.1783 1.1755 1.143 Calreticulin cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;endoplasmic reticulum membrane;integral to membrane;intrinsic to membrane;melanosome;membrane;membrane-bounded organelle;membrane-bounded vesicle;organelle;organelle membrane;vesicle binding;calcium ion binding;carbohydrate binding;cation binding;ion binding;metal ion binding;protein binding;sugar binding;unfolded protein binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular process;macromolecule metabolic process;metabolic process;protein folding;protein metabolic process;protein secretion;protein transport;secretion by cell;transport Antigen processing and presentation 19 19 19 32.9 32.9 32.9 67.567 9.9863E-261 2990300000 1550600000 1439700000 5755 IPI:IPI00941747.1;IPI:IPI00024776.1 Calnexin;Major histocompatibility complex class I antigen-binding protein p88;p90;IP90 CANX P27824 ENST00000247461 K08054 2 NaN NaN 0.67015 NaN NaN 0.8533 DSPc cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;hydrolase activity;hydrolase activity, acting on ester bonds;nucleic acid binding;phosphoprotein phosphatase activity;protein tyrosine phosphatase activity;protein tyrosine/serine/threonine phosphatase activity;RNA binding nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid dephosphorylation;protein modification process;RNA processing 2 2 2 7 7 7 38.938 0.00028286 14291000 7108700 7182200 5756 IPI:IPI00941817.1 RNA/RNP complex-1-interacting phosphatase;Phosphatase that interacts with RNA/RNP complex 1;Dual specificity protein phosphatase 11 DUSP11;PIR1 O75319-1;O75319 ENST00000272444;ENST00000377706 1 NaN 0.30981 NaN NaN 0.2091 NaN Pkinase_Tyr;SH2;SH3_1 ATP binding;binding;catalytic activity;kinase activity;non-membrane spanning protein tyrosine kinase activity;nucleoside binding;nucleotide binding;protein kinase activity;protein tyrosine kinase activity;purine nucleoside binding;transferase activity cell communication;cellular process;intracellular signaling cascade;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein kinase cascade;protein modification process;signal transduction 2 2 2 4.6 4.6 4.6 57.706 8.5312E-30 384370 0 384370 5758 IPI:IPI00941870.1 Tyrosine-protein kinase BLK;B lymphocyte kinase;p55-BLK BLK P51451 ENST00000259089 K08890 1 0.88481 1.8434 0.96198 1.1831 1.1833 1.2225 efhand cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;endoplasmic reticulum lumen;extracellular region;Golgi apparatus;melanosome;membrane-bounded organelle;membrane-bounded vesicle;membrane-enclosed lumen;organelle;sarcoplasmic reticulum lumen;vesicle binding;calcium ion binding;cation binding;ion binding;metal ion binding 5 5 2 16.5 16.5 2.9 37.106 2.7862E-14 337650000 167610000 170050000 5759 IPI:IPI00941900.1 Calumenin;Crocalbin;IEF SSP 9302 CALU O43852-1;O43852 ENST00000249364;ENST00000342367 1 0.30682 1.1713 0.36229 0.38486 0.77429 0.49225 HECT;RCC1;SPRY;WD40 cell part;cytoplasmic part;cytosol;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;organelle acid-amino acid ligase activity;ARF guanyl-nucleotide exchange factor activity;catalytic activity;guanyl-nucleotide exchange factor activity;ligase activity;ligase activity, forming carbon-nitrogen bonds;small GTPase regulator activity catabolic process;cellular process;macromolecule catabolic process;metabolic process;modification-dependent protein catabolic process;protein catabolic process;protein metabolic process;protein modification process;proteolysis;transport Ubiquitin mediated proteolysis 10 10 10 2.3 2.3 2.3 532.18 1.0761E-59 18045000 14286000 3758300 5760 IPI:IPI00941901.1 Probable E3 ubiquitin-protein ligase HERC1;HECT domain and RCC1-like domain-containing protein 1;p532;p619 HERC1 Q15751 ENST00000261887 K10594 1 0.829 1.597 0.8748 1.166 1.0263 1.1565 WD40 cell part;cytoplasm;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;organelle part;ribonucleoprotein complex;spliceosomal complex binding;identical protein binding;protein binding cellular process;metabolic process;mRNA metabolic process;mRNA processing;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;RNA metabolic process;RNA processing;RNA splicing 18 18 18 55.7 55.7 55.7 38.438 0 6039900000 4108300000 1931600000 5761 IPI:IPI00941907.1 Serine-threonine kinase receptor-associated protein;UNR-interacting protein;WD-40 repeat protein PT-WD;MAP activator with WD repeats STRAP;MAWD;UNRIP Q9Y3F4 ENST00000025399 1 0.73976 1.2736 0.7168 0.93604 0.89567 0.89838 HEAT cell part;holo TFIIH complex;intracellular organelle part;intracellular part;macromolecular complex;nuclear part;nucleoplasm part;organelle part;protein complex;transcription factor complex binding;protein binding;receptor binding;receptor signaling complex scaffold activity;structural molecule activity;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding DNA metabolic process;DNA repair;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleotide-excision repair;regulation of transcription, DNA-dependent;transcription;two-component signal transduction system (phosphorelay) 17 17 17 27.6 27.6 27.6 113.29 1.0494E-172 278040000 150940000 127100000 5762 IPI:IPI00941928.1;IPI:IPI00178649.9;IPI:IPI00640677.2;IPI:IPI00180322.4 MMS19 nucleotide excision repair protein homolog;MMS19-like protein;MET18 homolog MMS19;MMS19L Q96T76-1;Q96T76;Q96T76-5;Q96T76-4 ENST00000327238;ENST00000327277;ENST00000355839;ENST00000370782 4 0.60782 1.3479 0.59045 0.82092 0.89972 0.78632 4 4 4 9.9 9.9 9.9 48.544 2.6877E-16 16284000 9492500 6791200 5763 IPI:IPI00942040.1 Secernin-3 SCRN3 Q0VDG4 ENST00000272732 1 0.77864 1.5719 0.79055 1.0286 1.028 1.0399 ADSL_C;Lyase_1 cell part;cytoplasmic part;cytosol;intracellular part amidine-lyase activity;carbon-nitrogen lyase activity;catalytic activity;lyase activity;N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity AMP biosynthetic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process;protein complex assembly;purine nucleotide biosynthetic process;purine nucleotide metabolic process Alanine and aspartate metabolism;Purine metabolism 18 18 18 46.5 46.5 46.5 54.889 4.489E-253 1741800000 920100000 821680000 5764 IPI:IPI00942092.1;IPI:IPI00220887.1 Adenylosuccinate lyase;Adenylosuccinase ADSL;AMPS P30566-1;P30566;P30566-2 ENST00000216194;ENST00000342312 K01756 2 NaN 1.277 NaN NaN 0.86789 NaN Pkinase cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle ATP binding;binding;catalytic activity;kinase activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity apoptosis;cell communication;cell death;intracellular signaling cascade;metabolic process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein kinase cascade;protein modification process;signal transduction MAPK signaling pathway 16 9 9 34.6 20.2 20.2 56.3 0 40434000 21502000 18932000 5765 IPI:IPI00942120.1 Serine/threonine-protein kinase 3;STE20-like kinase MST2;Mammalian STE20-like protein kinase 2;Serine/threonine-protein kinase Krs-1 STK3;MST2 Q13188 ENST00000354930 K04412 1 0.59874 1.2354 0.60296 0.80141 0.78641 0.75898 Pkinase ATP binding;binding;catalytic activity;kinase activity;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;protein tyrosine kinase activity;purine nucleoside binding;transferase activity cell communication;intracellular signaling cascade;MAPKKK cascade;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein kinase cascade;protein modification process;response to stress;signal transduction Epithelial cell signaling in Helicobacter pylori infection;ErbB signaling pathway;Fc epsilon RI signaling pathway;GnRH signaling pathway;MAPK signaling pathway;Toll-like receptor signaling pathway 14 14 14 41.9 41.9 41.9 44.287 1.8608E-159 262930000 123640000 139290000 5766 IPI:IPI00942214.1 Dual specificity mitogen-activated protein kinase kinase 4;JNK-activating kinase 1;c-Jun N-terminal kinase kinase 1;SAPK/ERK kinase 1 MAP2K4;JNKK1;MKK4;PRKMK4;SERK1 P45985 ENST00000353533 K04430 1 0.88418 2.0554 NaN 1.1357 1.4417 NaN 2 2 2 11.7 11.7 11.7 29.251 2.6336E-47 6014000 2900000 3114000 5767 IPI:IPI00942215.1 ATP synthase subunit s-like protein ATP5SL Q9NW81-1;Q9NW81 ENST00000221943;ENST00000301183 1 0.63217 2.175 0.71012 0.95009 1.2168 0.90683 cell part;integral to membrane;intrinsic to membrane;membrane part 2 2 2 4.9 4.9 4.9 54.528 1.3698E-15 84978000 52738000 32240000 5768 IPI:IPI00942265.1 Solute carrier family 43 member 3;Protein FOAP-13 SLC43A3;PSEC0252 Q8NBI5 ENST00000352187;ENST00000395123;ENST00000395124 K08230 1 0.51165 1.1184 NaN 0.68156 0.72547 NaN Ank;Pre-SET;SET cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;catalytic activity;lysine N-methyltransferase activity;methyltransferase activity;N-methyltransferase activity;protein methyltransferase activity;S-adenosylmethionine-dependent methyltransferase activity;zinc ion binding cellular component organization;cellular process;chromatin modification;chromatin organization;metabolic process;one-carbon metabolic process;organelle organization;protein amino acid alkylation;protein amino acid methylation;protein modification process Lysine degradation 3 3 3 3.4 3.4 3.4 141.46 3.0849E-10 4691700 2684000 2007600 5769 IPI:IPI00946054.1;IPI:IPI00942420.1;IPI:IPI00645334.3 Histone-lysine N-methyltransferase, H3 lysine-9 specific 5;Histone H3-K9 methyltransferase 5;H3-K9-HMTase 5;Euchromatic histone-lysine N-methyltransferase 1;G9a-like protein 1;Lysine N-methyltransferase 1D EHMT1;EUHMTASE1;KIAA1876;KMT1D Q9H9B1-3;Q9H9B1;Q9H9B1-1 ENST00000298728;ENST00000334856;ENST00000371400 K11420 3 0.88665 1.8566 0.88944 1.2207 1.2312 1.1849 efhand cell part;coated pit;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane part;membrane-bounded organelle;nucleus;organelle binding;calcium ion binding;cation binding;ion binding;metal ion binding cellular component organization;cellular process;endocytosis;establishment of localization;membrane invagination;membrane organization;transport;vesicle-mediated transport 15 15 15 22 22 22 94.254 1.6764E-118 156580000 80193000 76391000 5770 IPI:IPI00942431.1 Epidermal growth factor receptor substrate 15-like 1;Eps15-related protein EPS15L1;EPS15R Q9UBC2 ENST00000248070 1 NaN 0.5704 0.27231 NaN 0.38001 0.33287 Adap_comp_sub AP-type membrane coat adaptor complex;cell part;clathrin adaptor complex;cytoplasmic part;intracellular part;macromolecular complex;membrane part;protein complex binding;protein binding cellular process;establishment of localization;establishment of localization in cell;establishment of protein localization;intracellular protein transport;intracellular transport;protein transport;transport;vesicle-mediated transport 3 3 3 9.4 9.4 9.4 54.766 5.1073E-05 3464100 2223600 1240400 5771 IPI:IPI00942480.1;IPI:IPI00061266.1 MHD domain-containing death-inducing protein;Mu-2-related death-inducing protein;Putative HIV-1 infection-related protein MUDENG;C14orf108 Q9H0R1-1;Q9H0R1;Q9H0R1-2 ENST00000261558 2 0.66285 1.6071 0.73341 0.92571 1.05 0.93037 MED6 cell part;intracellular organelle part;intracellular part;macromolecular complex;mediator complex;nuclear part;nucleoplasm part;organelle part;protein complex binding;general RNA polymerase II transcription factor activity;protein binding;RNA polymerase II transcription factor activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-dependent;transcription 2 2 2 12.6 12.6 12.6 28.424 0.00019401 19379000 10011000 9367900 5772 IPI:IPI00942495.1 Mediator of RNA polymerase II transcription subunit 6;Mediator complex subunit 6;Activator-recruited cofactor 33 kDa component;Renal carcinoma antigen NY-REN-28 MED6;ARC33 O75586 ENST00000256379 1 0.60128 1.2057 0.65995 0.74605 0.83078 0.83895 2 2 2 4.3 4.3 4.3 88.604 3.2827E-116 9271100 5322700 3948400 5773 IPI:IPI00942617.1;IPI:IPI00872712.1 Uncharacterized protein KIAA0415 KIAA0415 O43299-1;O43299;O43299-2 ENST00000348624;ENST00000401897 2 0.82243 1.4351 0.83981 1.0173 0.9746 1.0353 DUF323 endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;membrane-enclosed lumen;organelle;organelle lumen;organelle part binding;calcium ion binding;cation binding;ion binding;metal ion binding 9 9 9 36.2 36.2 36.2 33.857 1.8484E-69 133220000 67805000 65417000 5774 IPI:IPI00942652.1;IPI:IPI00334513.1;IPI:IPI00334514.2;IPI:IPI00334516.1 Sulfatase-modifying factor 2;C-alpha-formylglycine-generating enzyme 2 SUMF2;PSEC0171;UNQ1968/PRO4500 Q8NBJ7-1;Q8NBJ7;Q8NBJ7-2;Q8NBJ7-3 ENST00000275607;ENST00000342190;ENST00000395437 4 0.74504 1.4747 0.75963 1.0003 0.96166 1.0406 WW cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding 6 6 6 10.7 10.7 10.7 80.669 5.4689E-13 18088000 9609200 8478800 5775 IPI:IPI00942711.1 Phosphorylated CTD-interacting factor 1 PCIF1;C20orf67 Q9H4Z3 ENST00000372409 1 0.66519 1.8416 0.68312 0.89495 1.1569 0.86888 MRP-S27 intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;macromolecular complex;membrane-bounded organelle;mitochondrion;non-membrane-bounded organelle;organelle;ribonucleoprotein complex;ribosome 11 11 11 26.3 26.3 26.3 47.611 1.1506E-58 80915000 44518000 36397000 5776 IPI:IPI00942760.1 28S ribosomal protein S27, mitochondrial;MRP-S27 MRPS27;KIAA0264 Q92552 ENST00000261413 1 0.6036 1.2146 0.64318 0.83926 0.76041 0.869 Abhydrolase_1;Hydrolase cell fraction;cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;microbody;organelle;peroxisome;soluble fraction binding;catalytic activity;epoxide hydrolase activity;ether hydrolase activity;hydrolase activity;hydrolase activity, acting on ether bonds;identical protein binding;ion binding;magnesium ion binding;protein binding;protein homodimerization activity catabolic process;cellular aromatic compound metabolic process;cellular calcium ion homeostasis;cellular ion homeostasis;cellular metal ion homeostasis;metabolic process;oxygen and reactive oxygen species metabolic process;xenobiotic metabolic process Arachidonic acid metabolism;Tetrachloroethene degradation 16 16 16 39.8 39.8 39.8 62.615 5.5871E-142 515020000 280000000 235020000 5777 IPI:IPI00942976.1 Epoxide hydrolase 2;Soluble epoxide hydrolase;Epoxide hydratase;Cytosolic epoxide hydrolase EPHX2 P34913 ENST00000380476 K08726 1 0.68995 1.3759 0.69187 0.95191 0.8908 0.90009 Transket_pyr;Transketolase_C;Transketolase_N cell part;cytoplasmic part;cytosol;intracellular part binding;calcium ion binding;catalytic activity;cation binding;ion binding;metal ion binding;protein binding;transferase activity;transferase activity, transferring aldehyde or ketonic groups;transketolase activity metabolic process Biosynthesis of ansamycins;Carbon fixation in photosynthetic organisms;Pentose phosphate pathway 35 35 35 66 66 66 67.877 0 9588300000 5114200000 4474100000 5778 IPI:IPI00942979.1 Transketolase TKT P29401 ENST00000296289 K00615 1 2.9046 8.9163 3.0873 3.7663 5.5602 4.0085 2OG-FeII_Oxy cell part;cytoplasmic part;endoplasmic reticulum membrane;endoplasmic reticulum part;intracellular organelle part;intracellular part;membrane;membrane part;organelle membrane;organelle part;rough endoplasmic reticulum membrane binding;catalytic activity;iron ion binding;oxidoreductase activity;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen;procollagen-lysine 5-dioxygenase activity;protein binding cellular amino acid and derivative metabolic process;cellular amino acid metabolic process;metabolic process;nitrogen compound metabolic process;organic acid metabolic process;protein modification process;response to hypoxia;response to stress Lysine degradation 7 7 7 12 12 12 83.549 2.0974E-44 92190000 42132000 50058000 5779 IPI:IPI00943008.1 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1;Lysyl hydroxylase 1 PLOD1;LLH;PLOD Q02809 ENST00000196061 K00473 1 0.49403 0.94556 0.43562 0.61962 0.66128 0.53461 DUF1605;HA2;Helicase_C cell part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear part;nucleolus;organelle;organelle part ATP binding;ATP-dependent helicase activity;binding;catalytic activity;helicase activity;hydrolase activity;nucleic acid binding;nucleoside binding;nucleotide binding;purine nucleoside binding;pyrophosphatase activity 6 6 6 10.9 10.9 10.9 78.74 4.4088E-51 21000000 11675000 9324300 5780 IPI:IPI00943053.1;IPI:IPI00655950.1 Putative ATP-dependent RNA helicase DHX33;DEAH box protein 33 DHX33;DDX33 Q9H6R0-1;Q9H6R0;Q9H6R0-2 ENST00000225296 2 0.83871 1.7708 0.84424 1.1064 1.2097 1.0867 PRKCSH cell part;cytoplasmic part;endoplasmic reticulum;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;organelle binding;calcium ion binding;cation binding;ion binding;metal ion binding;protein binding biological regulation;cell communication;cellular process;intracellular signaling cascade;protein kinase cascade;regulation of biological process;regulation of cellular process;signal transduction 13 13 13 21 21 21 59.425 4.9216E-235 2355600000 1236000000 1119700000 5782 IPI:IPI00943074.1 Glucosidase 2 subunit beta;Glucosidase II subunit beta;Protein kinase C substrate 60.1 kDa protein heavy chain;80K-H protein PRKCSH;G19P1 P14314 ENST00000252455 K08288 1 0.77245 1.3929 0.68282 0.97486 0.95269 0.86063 C1_1;RhoGAP cell part;intracellular binding;cation binding;diacylglycerol binding;enzyme activator activity;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;ion binding;lipid binding;metal ion binding;transition metal ion binding;zinc ion binding biological regulation;cell communication;cellular process;intracellular signaling cascade;regulation of biological process;regulation of cellular process;signal transduction 17 17 17 20.9 20.9 20.9 124.61 7.818E-176 357320000 176510000 180810000 5783 IPI:IPI00943093.1 Minor histocompatibility protein HA-1;Minor histocompatibility antigen HA-1 HMHA1;KIAA0223 Q92619 ENST00000313093 1 0.52081 1.0345 0.51768 0.68146 0.66788 0.68808 DUF1899;DUF1900;WD40 actin cytoskeleton;cell part;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle actin binding;binding;cytoskeletal protein binding;protein binding cell communication;cellular component organization;cellular process;endocytosis;membrane invagination;membrane organization;phagocytosis;regulation of biological process;signal transduction;transport;vesicle-mediated transport 15 15 15 34.6 34.6 34.6 53.248 4.9023E-199 653300000 361040000 292260000 5784 IPI:IPI00943173.1;IPI:IPI00903139.1;IPI:IPI00789933.1;IPI:IPI00034860.10;IPI:IPI00939459.1 Coronin-1C;Coronin-3 CORO1C;CRNN4 Q9ULV4 ENST00000261401 5 0.54764 0.89754 0.50758 0.6913 0.63508 0.70115 Sec1 binding;protein binding;SNARE binding;syntaxin binding;syntaxin-2 binding;syntaxin-3 binding cellular process;establishment of localization;establishment of protein localization;intracellular protein transport;intracellular transport;membrane docking;protein transport;transport;vesicle docking;vesicle docking during exocytosis 13 13 13 31.4 31.4 31.4 66.438 0 88382000 46275000 42107000 5785 IPI:IPI00943192.1 Syntaxin-binding protein 2;Unc-18 homolog 2;Unc-18B STXBP2;UNC18B Q15833 ENST00000221283 1 0.85103 1.5154 0.75588 1.0641 0.98561 0.97411 NADH_oxidored cytoplasmic part;integral to membrane;intracellular part;intrinsic to membrane;macromolecular complex;membrane part;mitochondrial part;mitochondrial respiratory chain complex I;NADH dehydrogenase complex;organelle part;protein complex catalytic activity;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor cellular metabolic process;cellular process;electron transport chain;generation of precursor metabolites and energy;metabolic process;mitochondrial electron transport, NADH to ubiquinone;respiratory electron transport chain;transport 4 4 4 20 20 20 11.912 3.9222E-07 92038000 46850000 45188000 5786 IPI:IPI00025725.2;IPI:IPI00943798.1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1;NADH-ubiquinone oxidoreductase MNLL subunit;Complex I-MNLL NDUFB1 O75438-2;O75438;O75438-1 ENST00000329559 2 0.73769 1.396 0.71805 0.98748 0.90047 1.0117 Complex1_LYR cytoplasmic part;intracellular organelle part;intracellular part;macromolecular complex;membrane part;mitochondrial membrane part;mitochondrial part;mitochondrial respiratory chain complex I;NADH dehydrogenase complex;organelle part;protein complex catalytic activity;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity;oxidoreductase activity;oxidoreductase activity, acting on NADH or NADPH;oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor cellular process;electron transport chain;generation of precursor metabolites and energy;metabolic process;mitochondrial electron transport, NADH to ubiquinone;respiratory electron transport chain;response to oxidative stress;response to stress;transport Alzheimer's disease;Huntington's disease;Oxidative phosphorylation;Parkinson's disease 4 4 4 35.2 35.2 35.2 15.136 1.9796E-20 395490000 212470000 183020000 5787 IPI:IPI00945153.1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6;NADH-ubiquinone oxidoreductase B14 subunit;Complex I-B14;LYR motif-containing protein 6 NDUFA6;LYRM6;NADHB14 P56556 ENST00000331989 K03950 1 0.88048 1.4093 0.80639 1.1616 0.96703 1.0659 HEAT cell cortex;centrosome;condensed chromosome kinetochore;cytoplasmic microtubule;Golgi apparatus;kinetochore;kinetochore microtubule;macromolecular complex;membrane-bounded organelle;microtubule;microtubule organizing center;organelle;spindle microtubule binding;catalytic activity;cytoskeletal protein binding;fucosyltransferase activity;galactoside 2-alpha-L-fucosyltransferase activity;microtubule binding;protein binding;transferase activity;tubulin binding cellular process;establishment or maintenance of cell polarity;mitosis;negative regulation of metabolic process;negative regulation of microtubule depolymerization;nuclear division;organelle organization 19 19 14 17.2 17.2 13.8 141.13 5.1581E-160 206790000 92705000 114090000 5788 IPI:IPI00945554.1;IPI:IPI00167067.3 CLIP-associating protein 2;Cytoplasmic linker-associated protein 2 CLASP2;KIAA0627 O75122-1;O75122 ENST00000307312;ENST00000313350 2 NaN 1.1686 NaN NaN 0.72314 NaN Beach;DUF1088;WD40 binding;protein binding 29 1 1 12.6 0.5 0.5 317.7 0 941060 470050 471010 5789 IPI:IPI00945818.1 Lipopolysaccharide-responsive and beige-like anchor protein;CDC4-like protein;Beige-like protein LRBA;BGL;CDC4L;LBA P50851-2;P50851 ENST00000357115 1 0.69431 2.0745 0.88266 0.94377 1.3832 1.092 GRIM-19 integral to membrane;intracellular part;intrinsic to membrane;macromolecular complex;membrane part;mitochondrial part;mitochondrial respiratory chain complex I;NADH dehydrogenase complex;nuclear part;nucleoplasm;organelle part;protein complex ATP binding;binding;catalytic activity;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity;nucleoside binding;nucleotide binding;oxidoreductase activity;protein binding;purine nucleoside binding generation of precursor metabolites and energy;oxygen and reactive oxygen species metabolic process;protein import into nucleus;protein targeting;regulation of cell growth;regulation of transcription, DNA-dependent;regulation of translation;transport 6 6 6 27.8 27.8 27.8 25.865 1.1526E-22 227290000 118340000 108950000 5790 IPI:IPI00946421.1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13;NADH-ubiquinone oxidoreductase B16.6 subunit;Complex I-B16.6;Gene associated with retinoic-interferon-induced mortality 19 protein;Cell death regulatory protein GRIM-19 NDUFA13;GRIM19;CGI-39;CDA016 Q9P0J0 ENST00000252576 1 0.48596 0.74147 0.43276 0.59853 0.49789 0.57653 Ribonuc_red_sm cell part;cytoplasmic part;cytosol;intracellular part binding;catalytic activity;ion binding;iron ion binding;oxidoreductase activity;oxidoreductase activity, acting on CH or CH2 groups;oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor;ribonucleoside-diphosphate reductase activity biosynthetic process;DNA metabolic process;DNA replication;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;nucleoside phosphate metabolic process Glutathione metabolism;p53 signaling pathway;Purine metabolism;Pyrimidine metabolism 22 22 19 55.8 55.8 48.1 44.877 0 1237300000 680020000 557290000 5791 IPI:IPI00946732.1;IPI:IPI00438859.1 Ribonucleoside-diphosphate reductase subunit M2;Ribonucleotide reductase small subunit;Ribonucleotide reductase small chain RRM2;RR2 P31350 ENST00000304567;ENST00000360566 K10808 2 0.66692 1.2027 0.67592 0.81765 0.84805 0.84289 SET cell part;ESC/E(Z) complex;histone methyltransferase complex;intracellular organelle part;intracellular part;macromolecular complex;methyltransferase complex;nuclear part;nucleoplasm part;organelle part;PcG protein complex;protein complex binding;catalytic activity;DNA binding;methyltransferase activity;N-methyltransferase activity;nucleic acid binding;protein binding;protein methyltransferase activity;S-adenosylmethionine-dependent methyltransferase activity biosynthetic process;chromatin organization;metabolic process;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;regulation of transcription, DNA-dependent;transcription 7 7 7 12.5 12.5 12.5 85.362 9.2453E-61 90069000 49995000 40074000 5792 IPI:IPI00947357.1;IPI:IPI00921311.1;IPI:IPI00023672.7;IPI:IPI00921284.1;IPI:IPI00921136.1;IPI:IPI00921257.1 Histone-lysine N-methyltransferase EZH2;Enhancer of zeste homolog 2;ENX-1;Lysine N-methyltransferase 6 EZH2;KMT6 Q15910 ENST00000320356 6 0.72746 1.5668 0.87544 1.0411 1.0262 1.0846 Septin actin filament bundle;actomyosin;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;membrane-bounded organelle;nucleus;organelle;organelle part;protein complex;septin complex;stress fiber binding;GTP binding;guanyl nucleotide binding;guanyl ribonucleotide binding;nucleotide binding;protein binding;purine nucleotide binding;purine ribonucleotide binding;ribonucleotide binding anatomical structure formation;cell cycle;cell division;cellular component assembly;cellular component organization;cellular process;macromolecular complex subunit organization;protein complex assembly;protein heterooligomerization;protein oligomerization 17 8 7 39.6 22.6 18.2 49.398 1.6856E-210 340310000 162130000 178180000 5793 IPI:IPI00952909.1;IPI:IPI00019376.7 Septin-11 SEPT11 Q9NVA2-1;Q9NVA2;Q9NVA2-2 ENST00000264893 2 0.56381 NaN 0.61311 0.81425 NaN 0.87873 C2 cell part;integral to membrane;intrinsic to membrane;membrane;membrane part;plasma membrane 22 1 1 24.3 1.7 1.7 104.71 8.6905E-190 58120000 32375000 25745000 5794 IPI:IPI00953221.1 Extended synaptotagmin-2;Chr2Syt;Protein FAM62B FAM62B;ESYT2;KIAA1228 A0FGR8-6;A0FGR8 ENST00000251527 1 NaN NaN 0.84015 NaN NaN 1.1037 fn3;I-set;PH;Pkinase;RhoGEF;SH3_1;SH3_2;Spectrin actin cytoskeleton;cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle catalytic activity;guanyl-nucleotide exchange factor activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;small GTPase regulator activity cell communication;intracellular signaling cascade;metabolic process;nervous system development;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein modification process;signal transduction;transport 2 2 2 1 1 1 340.17 0.0061432 39715000 18415000 21299000 5795 IPI:IPI00953291.1;IPI:IPI00028382.3;IPI:IPI00021156.7;IPI:IPI00410728.2;IPI:IPI00410727.2 Kalirin;Huntingtin-associated protein-interacting protein;Protein Duo;Serine/threonine kinase with Dbl- and pleckstrin homology domain KALRN;DUET;DUO;HAPIP;TRAD O60229-1;O60229;O60229-2;O60229-4;O60229-6;O60229-5 ENST00000291478;ENST00000354186;ENST00000360013 K08810 5 0.80449 1.6814 0.79217 1.136 1.0739 1.0449 La binding;nucleic acid binding;RNA binding 10 9 9 17.1 16.3 16.3 80.551 1.3271E-87 139550000 76068000 63487000 5796 IPI:IPI00953461.1 La-related protein 5;La ribonucleoprotein domain family member 5 LARP5;KIAA0217 Q92615 ENST00000263154;ENST00000316157 1 0.67811 1.3831 0.70877 0.92002 0.89304 0.93931 FKBP_C;TPR_2 cell part;cytoplasmic part;cytosol;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle binding;protein binding;transcription activator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding;transcription regulator activity;unfolded protein binding biopolymer metabolic process;cellular biopolymer metabolic process;cellular metabolic process;cellular process;macromolecule metabolic process;metabolic process;protein folding;protein maturation by protein folding;protein metabolic process 14 14 14 46.9 46.9 46.9 38.489 5.2384E-184 708800000 378570000 330230000 5797 IPI:IPI00953925.1 AH receptor-interacting protein;Aryl-hydrocarbon receptor-interacting protein;Immunophilin homolog ARA9;HBV X-associated protein 2 AIP;XAP2 O00170 ENST00000279146 1 0.80115 0.19238 0.26854 1.1023 0.1155 0.36162 + + 2 2 2 2.4 2.4 2.4 101.51 0.0036523 63299000 20341000 42957000 5798 IPI:REV_CON_00717930.1 Q3T052;Q5EA67 1 1.145 2.0989 1.025 1.4704 1.3897 1.309 Filament;Filament_head cell part;cytoskeletal part;intermediate filament;intracellular organelle part;intracellular part;neurofilament;organelle part structural constituent of cytoskeleton;structural molecule activity anatomical structure development;cell differentiation;cellular developmental process;cellular process;developmental process;nervous system development;system development + 2 2 2 3.2 3.2 3.2 55.39 0.00037083 131630000 61419000 70207000 5800 IPI:REV_IPI00001453.2 Alpha-internexin;66 kDa neurofilament protein;Neurofilament-66 INA;NEF5 Q16352 ENST00000369849 K07608 1 NaN 0.70204 NaN NaN 0.49016 NaN ANF_receptor;Lig_chan;Lig_chan-Glu_bd cell junction;cell part;integral to membrane;intrinsic to membrane;membrane;membrane part;plasma membrane part;postsynaptic membrane;synapse part extracellular ligand-gated ion channel activity;ion channel activity;ionotropic glutamate receptor activity;receptor activity;signal transducer activity;transmembrane receptor activity;transporter activity cell communication;cell surface receptor linked signal transduction;cellular process;establishment of localization;glutamate signaling pathway;ion transport;regulation of biological process;regulation of cellular process;signal transduction;transport + 2 2 2 2.2 2.2 2.2 100.87 0.0067715 17885000 10100000 7784600 5805 IPI:REV_IPI00007632.2 Glutamate receptor 4;GluR-D;Glutamate receptor ionotropic, AMPA 4;AMPA-selective glutamate receptor 4 GRIA4;GLUR4 P48058 ENST00000282499 1 0.60086 1.5934 NaN 0.79984 1.0469 NaN Peptidase_S8 cell part;cytoplasm;intracellular part aminopeptidase activity;catalytic activity;endopeptidase activity;exopeptidase activity;hydrolase activity;peptidase activity;serine hydrolase activity;serine-type endopeptidase activity;serine-type peptidase activity;tripeptidyl-peptidase activity biopolymer catabolic process;biopolymer metabolic process;catabolic process;macromolecule catabolic process;macromolecule metabolic process;metabolic process;primary metabolic process;protein catabolic process;protein metabolic process;proteolysis + 3 3 3 3.2 3.2 3.2 138.35 0.00043403 48989000 27946000 21043000 5809 IPI:REV_IPI00020416.8 Tripeptidyl-peptidase 2;Tripeptidyl-peptidase II;Tripeptidyl aminopeptidase TPP2 P29144 ENST00000376052;ENST00000376065 K01280 1 NaN 1.9645 0.58335 NaN 1.1515 0.82486 IQ;Myosin_head;Myosin_N;Myosin_tail_1 cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;macromolecular complex;melanosome;membrane-bounded vesicle;muscle myosin complex;myosin complex;myosin filament;myosin II complex;organelle;striated muscle thick filament;vesicle actin binding;ATP binding;binding;calmodulin binding;catalytic activity;cytoskeletal protein binding;motor activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;structural molecule activity anatomical structure formation;cellular process;cytoskeleton organization;muscle contraction;muscle system process;organelle organization;protein complex assembly;smooth muscle contraction;striated muscle contraction;system process + 3 3 3 1.7 1.7 1.7 227.34 0.0041498 41195000 21497000 19698000 5810 IPI:REV_IPI00020501.1 Myosin-11;Myosin heavy chain 11;Myosin heavy chain, smooth muscle isoform;SMMHC MYH11;KIAA0866 P35749 ENST00000300036;ENST00000396324 1 0.7876 NaN NaN 1.0448 NaN NaN SH3_1;SH3_2 cell part;cytoplasm;cytoplasmic part;cytoskeleton;cytosol;endomembrane system;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane;non-membrane-bounded organelle;organelle binding;electron carrier activity;guanyl-nucleotide exchange factor activity;iron ion binding;protein binding;Ras guanyl-nucleotide exchange factor activity;receptor binding;Rho guanyl-nucleotide exchange factor activity;small GTPase regulator activity actin filament-based process;behavior;cell migration;cell motion;cellular component organization;cellular process;chemotaxis;cytoskeleton organization;immune system process;locomotory behavior;organelle organization;response to external stimulus Chemokine signaling pathway + 2 2 2 1.5 1.5 1.5 211.95 0.017309 130310000 70022000 60289000 5811 IPI:REV_IPI00022449.6;IPI:REV_IPI00015286.2 Dedicator of cytokinesis protein 2;Dedicator of cytokinesis protein 1;180 kDa protein downstream of CRK;DOCK180 DOCK2;KIAA0209;DOCK1 Q92608-1;Q92608;Q14185 ENST00000256935;ENST00000343291;ENST00000280333;ENST00000398025 K12367;K05727 2 NaN 1.6545 NaN NaN 1.0129 NaN BAH;Bromodomain;HMG_box cell part;chromosome;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;non-membrane-bounded organelle;nuclear chromosome;nuclear part;organelle;organelle part binding;chromatin binding;DNA binding;nucleic acid binding;protein binding chromatin organization;chromatin remodeling;mitosis;nitrogen compound metabolic process;nuclear division;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;regulation of transcription, DNA-dependent;transcription + 3 3 3 2.2 2.2 2.2 192.95 0.0023278 3957200 2753600 1203600 5812 IPI:REV_IPI00384176.1;IPI:REV_IPI00910435.1;IPI:REV_IPI00301041.4;IPI:REV_IPI00909142.1;IPI:REV_IPI00334894.1;IPI:REV_IPI00873041.1;IPI:REV_IPI00023097.1;IPI:REV_IPI00640304.1;IPI:REV_IPI00398781.3 Protein polybromo-1;Polybromo-1D;BRG1-associated factor 180 PBRM1;PB1 Q86U86-1;Q86U86;Q86U86-8;Q86U86-2;Q86U86-9;Q86U86-3;Q86U86-7;Q86U86-5;Q86U86-4 ENST00000296302;ENST00000337303;ENST00000356770;ENST00000394830 K11757 9 0.85783 1.5115 0.79913 1.1815 0.98678 1.0884 fn3;ig;I-set;Pkinase;PPAK;Titin_Z chromosome;condensed chromosome;condensed nuclear chromosome;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;nuclear chromosome;nuclear part;organelle;organelle part;Z disc actin binding;catalytic activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;small GTPase regulator activity DNA packaging;muscle contraction;muscle system process;phosphate metabolic process;phosphorus metabolic process;protein amino acid phosphorylation;protein complex assembly;protein modification process;striated muscle contraction;system process + 18 18 18 0.6 0.6 0.6 3829.8 1.4857E-13 2545300000 1443900000 1101400000 5813 IPI:REV_IPI00759542.1;IPI:REV_IPI00759754.1;IPI:REV_IPI00023283.3;IPI:REV_IPI00179357.2;IPI:REV_IPI00759637.1;IPI:REV_IPI00952748.1;IPI:REV_IPI00455173.4;IPI:REV_IPI00783950.1 Titin;Connectin;Rhabdomyosarcoma antigen MU-RMS-40.14 TTN Q8WZ42-8;Q8WZ42;Q8WZ42-1;Q8WZ42-2;Q8WZ42-7;Q8WZ42-4;Q8WZ42-5;Q8WZ42-3 ENST00000360870;ENST00000375038 8 0.62199 3.2638 1.7587 0.89887 1.9406 2.593 PDZ cell part;cytoplasmic part;Golgi apparatus;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane;membrane-bounded organelle;nucleus;organelle;plasma membrane binding;protein binding axon ensheathment;behavior;cellular process;ensheathment of neurons;mechanosensory behavior;response to abiotic stimulus;response to external stimulus;response to mechanical stimulus;response to stimulus + 4 4 4 2.7 2.7 2.7 155 0.00063918 337200000 159740000 177460000 5814 IPI:REV_IPI00024853.2;IPI:REV_IPI00221069.1 Periaxin PRX;KIAA1620 Q9BXM0-1;Q9BXM0;Q9BXM0-3 ENST00000291825;ENST00000324001;ENST00000341562 2 0.88671 1.4636 0.85005 1.2372 1.0487 1.0351 EGF_2;Fibrinogen_C;fn3 cell part;extracellular matrix;extracellular region part;extracellular space;intracellular;proteinaceous extracellular matrix binding;carbohydrate binding;glycosaminoglycan binding;heparin binding;integrin binding;pattern binding;polysaccharide binding;protein binding;protein complex binding;receptor binding anatomical structure formation;biological adhesion;cell adhesion;cell communication;cellular component assembly;cellular component organization;cellular process;cytoskeleton organization;metabolic process;organelle organization;signal transduction + 5 5 5 1.8 1.8 1.8 464.45 0.0026947 88042000 41712000 46329000 5815 IPI:REV_IPI00025276.1;IPI:REV_IPI00744907.4 Tenascin-X;Hexabrachion-like protein TNXB;HXBL;TNX;TNXB1;TNXB2;XB P22105-1;P22105;P22105-3 ENST00000299669;ENST00000375247 2 NaN 1.3866 NaN NaN 0.8949 NaN Sec8_exocyst cell cortex part;cell part;cytoplasmic part;exocyst;intracellular part;macromolecular complex;protein complex binding;protein binding cellular process;establishment of localization;establishment of protein localization;membrane docking;protein transport;transport;vesicle docking;vesicle docking during exocytosis + 2 2 2 3.4 3.4 3.4 110.5 0.0051614 48718000 27989000 20730000 5818 IPI:REV_IPI00059279.5 Exocyst complex component 4;Exocyst complex component Sec8 EXOC4;KIAA1699;SEC8;SEC8L1 Q96A65 ENST00000253861 1 0.86449 1.534 0.83151 1.0354 1.0113 1.0781 FAT;FATC;PI3_PI4_kinase H4/H2A histone acetyltransferase complex;histone acetyltransferase complex;macromolecular complex;NuA4 histone acetyltransferase complex;PCAF complex;protein complex;STAGA complex;transcription factor complex;transcription factor TFTC complex binding;catalytic activity;phosphotransferase activity, alcohol group as acceptor;protein binding;transcription cofactor activity;transcription factor binding;transferase activity;transferase activity, transferring phosphorus-containing groups chromatin organization;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;protein amino acid acetylation;protein modification process;regulation of transcription, DNA-dependent;transcription + 5 5 5 1.5 1.5 1.5 437.6 0.0023409 424720000 217590000 207130000 5820 IPI:REV_IPI00069084.2;IPI:REV_IPI00879277.2;IPI:REV_IPI00795880.2;IPI:REV_IPI00385917.4 Transformation/transcription domain-associated protein;350/400 kDa PCAF-associated factor;PAF350/400;STAF40;Tra1 homolog TRRAP;PAF400 Q9Y4A5-1;Q9Y4A5;Q9Y4A5-2 ENST00000355540;ENST00000359863 K08874 4 NaN 0.91602 NaN NaN 0.65304 NaN EFG_C;EFG_IV;GTP_EFTU;GTP_EFTU_D2 cell part;cytoplasmic part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;organelle binding;catalytic activity;GTP binding;GTPase activity;hydrolase activity;nucleic acid binding;nucleotide binding;pyrophosphatase activity;translation elongation factor activity;translation factor activity, nucleic acid binding biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;protein metabolic process;translation + 2 2 2 2.7 2.7 2.7 90.505 0.0001084 1442600 381580 1061100 5821 IPI:REV_IPI00071703.2;IPI:REV_IPI00945410.1;IPI:REV_IPI00216419.1;IPI:REV_IPI00946969.1;IPI:REV_IPI00172648.1 Elongation factor G 2, mitochondrial;mEF-G 2;Elongation factor G2 GFM2;EFG2;MSTP027 Q969S9-1;Q969S9;Q969S9-3;Q969S9-2;Q969S9-4;Q969S9-5 ENST00000296805;ENST00000345239 K02355 5 0.98195 1.283 0.97214 1.1999 0.91357 1.2076 PAZ;Piwi cell part;chromatoid body;cytoplasmic part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;macromolecular complex;non-membrane-bounded organelle;organelle;P granule;ribonucleoprotein complex binding;nucleic acid binding;piRNA binding;RNA binding DNA alkylation;DNA metabolic process;DNA methylation;DNA modification;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;one-carbon metabolic process;regulation of translation;RNA 5'-end processing;RNA processing Dorso-ventral axis formation + 3 3 3 2.7 2.7 2.7 109.85 0.0026783 406440000 196600000 209830000 5823 IPI:REV_IPI00154664.1;IPI:REV_IPI00923514.1 Piwi-like protein 2;Cancer/testis antigen 80 PIWIL2;HILI Q8TC59-1;Q8TC59;Q8TC59-2 ENST00000356766 K02156 2 0.83087 NaN 0.75143 1.0896 NaN 1.116 fn3;SPRY cell part;cytoplasmic part;intracellular part;perinuclear region of cytoplasm + 4 4 4 1.3 1.3 1.3 449.21 0.0034592 6463900 3570800 2893100 5825 IPI:REV_IPI00166612.9;IPI:REV_CON_00702736.3 Cardiomyopathy-associated protein 5;Myospryn;Dystrobrevin-binding protein 2;SPRY domain-containing protein 2;Tripartite motif-containing protein 76;Genethonin-3 CMYA5;C5orf10;DTNBP2;SPRYD2;TRIM76 Q8N3K9 ENST00000238522 2 NaN 1.6052 0.70679 NaN 1.0181 1.0079 dsrm;DZF cell part;cytoplasm;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;mitochondrion;non-membrane-bounded organelle;nucleolus;nucleus;organelle binding;DNA binding;double-stranded RNA binding;nucleic acid binding;protein binding;RNA binding;transcription activator activity;transcription regulator activity;transcription repressor activity developmental process;M phase;multicellular organismal development;multicellular organismal process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;regulation of transcription, DNA-dependent;transcription + 2 2 2 3 3 3 73.652 0.003268 47542000 26337000 21205000 5826 IPI:REV_IPI00169430.2;IPI:REV_IPI00413860.4;IPI:REV_IPI00418313.3;IPI:REV_IPI00298788.4;IPI:REV_IPI00414335.2;IPI:REV_IPI00556173.1;IPI:REV_IPI00298789.2;IPI:REV_IPI00219330.2 Spermatid perinuclear RNA-binding protein;Interleukin enhancer-binding factor 3;Nuclear factor of activated T-cells 90 kDa;Double-stranded RNA-binding protein 76;Translational control protein 80;Nuclear factor associated with dsRNA;M-phase phosphoprotein 4 STRBP;SPNR;ILF3;DRBF;MPHOSPH4;NF90 Q96SI9-1;Q96SI9;Q96SI9-2;Q12906-4;Q12906;Q12906-1;Q12906-3;Q12906-6;Q12906-2;Q12906-5 ENST00000348403;ENST00000373638;ENST00000250241;ENST00000318511;ENST00000336059;ENST00000407004 8 0.27286 NaN NaN 0.36329 NaN NaN Ribosomal_L18e cell part;cytoplasmic part;cytosolic large ribosomal subunit;cytosolic part;intracellular organelle part;intracellular part;large ribosomal subunit;macromolecular complex;organelle part;ribonucleoprotein complex;ribosomal subunit binding;nucleic acid binding;RNA binding;structural constituent of ribosome;structural molecule activity biosynthetic process;cellular biopolymer biosynthetic process;cellular biopolymer metabolic process;cellular macromolecule biosynthetic process;cellular process;macromolecule biosynthetic process;metabolic process;translational elongation Ribosome + 2 2 2 10.6 10.6 10.6 21.634 0.0051662 1998100 1523000 475110 5830 IPI:REV_IPI00215719.6 60S ribosomal protein L18 RPL18 Q07020 ENST00000084795 K02883 1 0.74351 1.7137 1.0532 0.9568 1.1837 1.4101 CH;KASH;Spectrin cytoplasm;cytoskeleton;integral to membrane;intracellular organelle;intrinsic to membrane;membrane;non-membrane-bounded organelle;nuclear membrane;nuclear outer membrane;organelle;organelle membrane;organelle outer membrane;outer membrane actin binding;binding;cytoskeletal protein binding;protein binding + 6 6 6 1 1 1 798.85 5.3555E-05 38342000 20183000 18160000 5835 IPI:REV_IPI00239406.2;IPI:REV_IPI00239405.4;IPI:REV_IPI00239413.4;IPI:REV_IPI00815967.1;IPI:REV_IPI00239409.1 Nesprin-2;Nuclear envelope spectrin repeat protein 2;Synaptic nuclear envelope protein 2;Nucleus and actin connecting element protein SYNE2;KIAA1011;NUA Q8WXH0-2;Q8WXH0;Q8WXH0-1;Q8WXH0-7 ENST00000261678;ENST00000341472;ENST00000344113;ENST00000356081;ENST00000357395;ENST00000358025 5 0.70541 1.8391 1.0749 0.95251 1.1627 1.4292 CH;KASH;Spectrin cytoskeleton;Golgi apparatus;integral to membrane;intrinsic to membrane;membrane;membrane-bounded organelle;nuclear membrane;nuclear outer membrane;organelle;organelle membrane;organelle outer membrane;outer membrane;sarcomere actin binding;binding;cytoskeletal protein binding;lamin binding;protein binding cell death;cell differentiation;cellular component organization;cellular developmental process;cellular process;death;developmental process;Golgi organization;muscle cell differentiation;nucleus organization;organelle organization + 6 6 6 0.7 0.7 0.7 1011 1.8485E-06 69260000 38157000 31103000 5836 IPI:REV_IPI00386444.3;IPI:REV_IPI00247295.4;IPI:REV_IPI00647370.2;IPI:REV_IPI00247296.2;IPI:REV_IPI00396977.2;IPI:REV_IPI00943590.1;IPI:REV_IPI00940636.2;IPI:REV_IPI00170463.2;IPI:REV_IPI00247300.4 Nesprin-1;Nuclear envelope spectrin repeat protein 1;Synaptic nuclear envelope protein 1;Myocyte nuclear envelope protein 1 SYNE1;KIAA0796;KIAA1262;KIAA1756;MYNE1 Q8NF91-1;Q8NF91;Q8NF91-4;Q8NF91-6;Q8NF91-5;Q8NF91-7 ENST00000265368;ENST00000341594;ENST00000347037;ENST00000356820;ENST00000367255;ENST00000367257 9 0.90476 1.5652 1.0038 1.1108 1.0813 1.2627 Vinculin actin cytoskeleton;adherens junction;cell junction;cell-cell junction;cell-substrate adherens junction;cell-substrate junction;costamere;cytoskeleton;focal adhesion;intracellular organelle;macromolecular complex;non-membrane-bounded organelle;organelle actin binding;alpha-catenin binding;binding;catalytic activity;cytoskeletal protein binding;oxidoreductase activity;protein binding;structural molecule activity anatomical structure formation;biological adhesion;cell adhesion;cell motion;cell projection assembly;cell projection organization;cell-cell junction assembly;cellular component assembly;cellular component organization;cellular process Adherens junction;Focal adhesion;Leukocyte transendothelial migration;Regulation of actin cytoskeleton + 2 2 2 1.8 1.8 1.8 123.8 0.0050152 96146000 51267000 44880000 5837 IPI:REV_IPI00307162.2;IPI:REV_IPI00291175.7 Vinculin;Metavinculin VCL P18206-1;P18206;P18206-2 ENST00000211998;ENST00000372755 K05700 2 NaN 42.702 NaN NaN 29.237 NaN CH;efhand;GAS2;Plectin;Spectrin basement membrane;cell junction;cell-substrate junction;cytoplasmic membrane-bounded vesicle;cytoplasmic vesicle;cytoskeleton;hemidesmosome;membrane-bounded organelle;membrane-bounded vesicle;non-membrane-bounded organelle;organelle;vesicle actin binding;actin filament binding;binding;calcium ion binding;cation binding;cytoskeletal protein binding;integrin binding;ion binding;metal ion binding;protein binding;protein complex binding;protein C-terminus binding;receptor binding biological adhesion;cell adhesion;cell communication;cell surface receptor linked signal transduction;cellular component organization;cellular process;cytoskeleton organization;integrin-mediated signaling pathway;organelle organization;signal transduction + 4 4 3 0.8 0.8 0.6 632.52 0.00061417 120990000 112290000 8702500 5838 IPI:REV_IPI00921479.1;IPI:REV_IPI00293251.5;IPI:REV_IPI00654639.2;IPI:REV_IPI00015631.3 Bullous pemphigoid antigen 1, isoforms 1/2/3/4/5/8;230 kDa bullous pemphigoid antigen;Hemidesmosomal plaque protein;Dystonia musculorum protein;Bullous pemphigoid antigen 1, isoforms 6/9/10;Trabeculin-beta DST;BPAG1;DMH;DT;KIAA0728 Q03001-1;Q03001;O94833-2;O94833;O94833-3 ENST00000281662;ENST00000370765;ENST00000370769;ENST00000244364 K10382 4 0.92013 1.6833 0.88213 1.2652 1.0714 1.196 IQ;Myosin_head;Myosin_N;Myosin_tail_1 cytoplasmic part;cytoskeletal part;intracellular organelle part;intracellular part;macromolecular complex;muscle myosin complex;myosin complex;myosin filament;myosin II complex;organelle part;protein complex;striated muscle thick filament actin binding;ATP binding;binding;calmodulin binding;catalytic activity;cytoskeletal protein binding;microfilament motor activity;motor activity;nucleoside binding;nucleotide binding;protein binding;purine nucleoside binding;pyrophosphatase activity actin filament-based movement;actin filament-based process;cellular process;cytoskeleton-dependent intracellular transport;muscle contraction;muscle organ development;muscle system process;striated muscle contraction;system process;transport Tight junction + 2 2 1 1 1 0.5 223.9 0.0053915 489370000 254910000 234450000 5839 IPI:REV_IPI00298301.4 Myosin-3;Myosin heavy chain 3;Myosin heavy chain, fast skeletal muscle, embryonic;Muscle embryonic myosin heavy chain;SMHCE MYH3 P11055 ENST00000226209 K10352 1 0.9688 1.7961 0.89828 1.2968 1.1416 1.1951 Nebulin;SH3_1 actin cytoskeleton;cell part;contractile fiber part;cytoplasmic part;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;non-membrane-bounded organelle;organelle;Z disc actin binding;binding;cytoskeletal protein binding;protein binding;structural constituent of muscle;structural molecule activity developmental process;muscle organ development;regulation of actin cytoskeleton organization;regulation of actin filament length;regulation of actin filament-based process;regulation of cellular component size;somatic muscle development + 4 4 4 0.8 0.8 0.8 772.93 0.0060458 106210000 56391000 49823000 5840 IPI:REV_IPI00303335.2 Nebulin NEB P20929 ENST00000172853;ENST00000409198 1 0.66831 1.559 NaN 0.88456 1.0215 NaN N1221 cell part;intracellular membrane-bounded organelle;intracellular organelle;intracellular part;membrane-bounded organelle;nucleus;organelle + 2 2 2 3 3 3 95.575 0.0024557 28687000 16606000 12082000 5841 IPI:REV_IPI00549766.2;IPI:REV_IPI00619947.1;IPI:REV_IPI00304540.9;IPI:REV_IPI00939477.1;IPI:REV_IPI00005300.4 Protein FAM40A;Protein FAM40B FAM40A;KIAA1761;FAM40B;KIAA1170 Q5VSL9-1;Q5VSL9;Q5VSL9-2;Q5VSL9-3;Q9ULQ0-1;Q9ULQ0;Q9ULQ0-2 ENST00000369794;ENST00000369795;ENST00000249344 5 0.76822 1.2268 0.73298 1.0301 0.79055 0.96579 chromatin;chromosomal part;cytoplasm;heterochromatin;intracellular organelle part;intracellular part;nuclear chromatin;nuclear chromosome part;nuclear heterochromatin;nuclear part;nuclear telomeric heterochromatin;organelle part;telomeric heterochromatin ankyrin binding;binding;cytoskeletal protein binding;enzyme binding;protein binding DNA metabolic process;DNA replication;nitrogen compound metabolic process;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;organelle organization;RNA-dependent DNA replication;telomere maintenance;telomere maintenance via telomerase + 2 2 2 1.4 1.4 1.4 181.78 0.005816 50351000 25346000 25005000 5842 IPI:REV_IPI00304589.4 182 kDa tankyrase-1-binding protein TNKS1BP1;KIAA1741;TAB182 Q9C0C2-1;Q9C0C2 ENST00000326757;ENST00000358252 1 NaN NaN 0.81516 NaN NaN 1.1495 CS immune response;immune system process;response to stimulus + 2 1 1 1.9 1.9 1.9 66.775 0.0029857 24950000 14467000 10483000 5843 IPI:REV_IPI00797537.2;IPI:REV_IPI00306398.7;IPI:REV_IPI00789225.2 NudC domain-containing protein 1;Chronic myelogenous leukemia tumor antigen 66;Tumor antigen CML66 NUDCD1;CML66 Q96RS6-1;Q96RS6;Q96RS6-2;Q96RS6-3 ENST00000239690 3 NaN 31.819 NaN NaN 18.904 NaN Ank;FERM_M cell part;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane;non-membrane-bounded organelle;organelle binding;enzyme regulator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity;protein binding;small GTPase regulator activity biological regulation;cell communication;cellular process;intracellular signaling cascade;regulation of biological process;regulation of cellular process;signal transduction;small GTPase mediated signal transduction + 3 2 2 4.6 3.8 3.8 84.347 0.0006388 5114300 4205200 909110 5849 IPI:REV_IPI00418142.2;IPI:REV_IPI00651671.1 Krev interaction trapped protein 1;Cerebral cavernous malformations 1 protein KRIT1;CCM1 O00522-1;O00522;O00522-2 ENST00000340022;ENST00000394505;ENST00000394507 2 0.65828 1.4704 NaN 0.89665 0.94698 NaN PDZ extracellular region part;extracellular space binding;cytokine activity;protein binding;receptor binding behavior;chemotaxis;immune response;immune system process;locomotion;locomotory behavior;response to chemical stimulus;response to external stimulus;response to stimulus;taxis + 4 4 4 4.6 4.6 4.6 141.75 0.00086309 25423000 14712000 10711000 5851 IPI:REV_IPI00442038.3;IPI:REV_IPI00853332.1;IPI:REV_IPI00289966.4 Pro-interleukin-16;Interleukin-16;Lymphocyte chemoattractant factor IL16 Q14005-1;Q14005;Q14005-2;Q14005-3 ENST00000302987;ENST00000360547;ENST00000394652;ENST00000394653;ENST00000394656 3 1.0922 1.7294 1.0617 1.3886 1.1861 1.329 centrosome;cytoplasmic part;cytoskeletal part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular organelle part;intracellular part;microtubule organizing center;non-membrane-bounded organelle;organelle;organelle part + 3 3 3 1.2 1.2 1.2 279.11 0.00076216 7925500 4765400 3160100 5852 IPI:REV_IPI00456708.5;IPI:REV_IPI00940639.1 Centrosomal protein of 192 kDa CEP192;KIAA1569;PP8407 Q8TEP8-1;Q8TEP8 ENST00000325971 2 0.88824 0.97346 0.7911 1.0998 0.66818 0.95602 FYVE binding;cation binding;ion binding;metal ion binding;transition metal ion binding;zinc ion binding cell death;cellular process;death + 3 3 3 0.8 0.8 0.8 284.63 5.3115E-05 679000000 401810000 277190000 5853 IPI:REV_IPI00879253.1;IPI:REV_IPI00470896.3 Zinc finger FYVE domain-containing protein 26;Spastizin ZFYVE26;KIAA0321 Q68DK2-1;Q68DK2;Q68DK2-2 ENST00000347230;ENST00000394455 2 0.80922 NaN NaN 1.0607 NaN NaN Syja_N catalytic activity;hydrolase activity + 2 2 2 2.2 2.2 2.2 128.41 0.0011287 15151000 10591000 4559500 5854 IPI:REV_IPI00480159.1 Phosphatidylinositide phosphatase SAC2;Sac domain-containing inositol phosphatase 2;Sac domain-containing phosphoinositide 5-phosphatase 2;Inositol polyphosphate 5-phosphatase F INPP5F;KIAA0966;SAC2;MSTP007;MSTP047 Q9Y2H2-1;Q9Y2H2 ENST00000361976 1 0.99952 1.6508 1.0232 1.1792 1.0286 1.2232 DUF1908;PDZ;Pkinase;Pkinase_C cell part;cytoplasm;intracellular part ATP binding;binding;catalytic activity;kinase activity;magnesium ion binding;nucleoside binding;nucleotide binding;protein binding;protein kinase activity;protein serine/threonine kinase activity;purine nucleoside binding;transferase activity cellular biopolymer metabolic process;cellular process;metabolic process;phosphate metabolic process;phosphorus metabolic process;phosphorylation;protein amino acid phosphorylation;protein metabolic process;protein modification process + 3 3 3 1.3 1.3 1.3 284.37 0.0026175 79742000 38739000 41004000 5858 IPI:REV_IPI00914890.1;IPI:REV_IPI00894093.2;IPI:REV_IPI00827896.6;IPI:REV_IPI00788168.4 Microtubule-associated serine/threonine-protein kinase 4 MAST4;KIAA0303 O15021-5;O15021;O15021-1;O15021-3;O15021-2 ENST00000403625 K08789 4 5.4983 0.36031 0.58286 7.8441 0.23648 0.73515 HELP;WD40 cell part;cytoplasm;cytoskeletal part;intracellular organelle part;intracellular part;microtubule;organelle part + 4 4 4 2.5 2.5 2.5 217.9 0.00039459 5540300 3782900 1757300 5859 IPI:REV_IPI00895879.1;IPI:REV_IPI00847255.4;IPI:REV_IPI00923627.1;IPI:REV_IPI00742831.3;IPI:REV_IPI00843972.1 Echinoderm microtubule-associated protein-like 6;Echinoderm microtubule-associated protein-like 5-like EML6;EML5L Q6ZMW3-1;Q6ZMW3;Q6ZMW3-2 5 0.78098 1.5329 0.85929 0.91493 1.0485 1.0167 Beta-lactamase + 3 3 3 9.3 9.3 9.3 56.4 0.0033204 280070000 143140000 136930000 5860 IPI:REV_IPI00873576.3 Putative beta-lactamase-like protein ENSP00000383859 A8MY62 ENST00000401081 1 NaN 1.7795 0.95347 NaN 1.1291 1.113 Ank;Death;ZU5 basolateral plasma membrane;cell part;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular part;membrane part;non-membrane-bounded organelle;organelle;plasma membrane part binding;protein binding biological regulation;cell communication;cellular process;establishment of localization;establishment of protein localization;regulation of biological process;regulation of cellular process;signal transduction + 4 4 4 1.1 1.1 1.1 480.4 0.0031736 35407000 17211000 18196000 5861 IPI:REV_IPI00921566.2 Ankyrin-3;Ankyrin-G ANK3 Q12955 ENST00000280772;ENST00000373827 1 0.73051 NaN NaN 1.0093 NaN NaN + 3 3 3 0.5 0.5 0.5 784.9 0.00014208 678190 308280 369920 5862 IPI:REV_IPI00937077.1 Uncharacterized protein FLJ40176 Q8NDH2 ENST00000322527 1 0.83913 1.1549 0.66727 1.0407 0.82092 0.80977 BIR;UQ_con cell part;intracellular binding;cysteine-type endopeptidase inhibitor activity;endopeptidase inhibitor activity;enzyme inhibitor activity;enzyme regulator activity;peptidase inhibitor activity;protein binding anti-apoptosis;apoptosis;catabolic process;cell death;cellular process;death;macromolecule catabolic process;metabolic process;programmed cell death;protein modification process;proteolysis;regulation of cell death;regulation of metabolic process Ubiquitin mediated proteolysis + 3 2 2 0.6 0.5 0.5 527.6 0.0032733 91075000 46924000 44151000 5863 IPI:REV_IPI00939720.1 Baculoviral IAP repeat-containing protein 6;Ubiquitin-conjugating BIR domain enzyme apollon BIRC6;KIAA1289 Q9NR09 ENST00000261359 K10586 1